Herba portulacae and herba dendrobii composition for specific dermatitis and skin care spray

Abstract

The invention relates to a herba portulacae and herba dendrobii composition for specific dermatitis. The herba portulacae and herba dendrobii composition is prepared from the following components in parts by weight: 10-50 parts of fresh herba portulacae extract and 5-30 parts of fresh herba dendrobii extract. The invention solves the following technical problems: how to optimize the compatibility of a traditional Chinese medicine compound and provide a traditional Chinese medicine composition which is safe, effective and capable of quickly relieving skin lesion and relieving itching, so that the dosage of glucocorticoid ointment is reduced; the effective components of the traditional Chinese medicinal materials are reserved to the maximum extent through an innovative extraction process; a novel drug delivery system is designed, bioavailability is improved, and use is convenient.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine, and particularly relates to a purslane and dendrobium composition and a skin care spray for treating atopic dermatitis. Background Art

[0002] Atopic dermatitis (AD) is a common skin inflammation, which is common in children and has a genetic tendency. It manifests as acute and chronic eczematoid skin lesions, dry skin and obvious itching, which has a serious impact on the patient's normal life. It is usually caused by internal and external infections and non-infectious factors, such as internal chronic diseases, genetics, endocrine factors, and external stimuli such as food, sunlight, and dust. Traditional treatment methods often use glucocorticoid ointments, but long-term use may cause side effects. Therefore, it is of great significance to develop a safe and effective Chinese medicine composition for the treatment of atopic dermatitis.

[0003] Purslane is a common wild plant that has the effects of clearing away heat and detoxifying, cooling blood and reducing swelling. It is often used to treat skin inflammation, eczema and other diseases. It is rich in bioactive ingredients such as flavonoids, terpenes, polysaccharides, and has anti-inflammatory, antioxidant, and antibacterial effects. As one of the traditional precious Chinese medicinal materials, Dendrobium is often used in food and medicine without obvious side effects. Its stems are rich in polyphenol compounds and alkaloids, which have a significant nourishing and repairing effect on the skin.

[0004] The present invention has found that the combination of purslane and dendrobium has many advantages in treating atopic dermatitis, including enhancing efficacy, immunomodulation, anti-inflammatory and antibacterial, reducing hormone dependence, improving inflammatory state and improving quality of life. In addition, the Chinese medicine composition of purslane and dendrobium can reduce dependence on glucocorticoid ointment and avoid side effects caused by long-term use. At present, there is no technical report on the combination of purslane and dendrobium in treating atopic dermatitis. Summary of the invention

[0005] The purpose of the present invention is to overcome the defects of the prior art and provide a purslane and dendrobium composition and a skin care spray for treating atopic dermatitis, aiming to solve the following technical problems: how to optimize the compatibility of Chinese medicine compound prescriptions, provide a safe, effective and rapid Chinese medicine composition for reducing skin lesions and relieving itching, thereby reducing the amount of glucocorticoid ointment used; how to maximize the retention of the effective ingredients of each Chinese medicinal material through an innovative extraction process; how to design a new drug delivery system to improve bioavailability and facilitate use.

[0006] The present invention also provides a preparation method and application of the purslane and dendrobium composition for treating atopic dermatitis.

[0007] To achieve the above object, the present invention adopts the following technical solutions:

[0008] A purslane and dendrobium composition for treating atopic dermatitis consists of the following ingredients in proportion by weight: 10-50 parts of purslane fresh extract and 5-30 parts of dendrobium fresh extract.

[0009] As a preferred embodiment, the purslane and dendrobium composition for atopic dermatitis is composed of the following ingredients in the following weight proportions: 15-35 parts of purslane fresh extract and 10-15 parts of dendrobium fresh extract.

[0010] Further preferably, the purslane and dendrobium composition for atopic dermatitis is composed of the following ingredients in the following weight ratio: 15 parts of purslane fresh extract and 10 parts of dendrobium fresh extract.

[0011] The present invention provides a method for preparing the purslane and dendrobium composition for atopic dermatitis, which comprises the following steps:

[0012] 1) taking a certain amount of fresh dendrobium or fresh purslane, adding a certain amount of pectinase, protease, cellulase and water, crushing and grinding (during grinding, the colloid mill keeps the material temperature at 35-45° C.) to obtain plant slurry, separating the solid and liquid, and taking the supernatant;

[0013] 2) adding a mixture of activated clay, activated carbon and diatomaceous earth to the supernatant obtained in step 1) at 60-100° C. and keeping the temperature for 10-60 min; separating the solid and the liquid and taking the supernatant;

[0014] 3) ultrafiltration separation of the supernatant obtained in step 2) and collection of the permeate to obtain fresh extract of purslane or dendrobium, and mixing the two in proportion to obtain the obtained product.

[0015] In the preparation process of the purslane and dendrobium composition for atopic dermatitis, in step 1), the mass ratio of pectinase, protease and cellulase is 2-3:1:2-3, and the sum of the mass of pectinase, protease and cellulase is 0.7-0.9% of the mass of the extracted raw material; the amount of water added is 10-20 times the mass of the extracted raw material;

[0016] In step 2), the mass ratio of activated clay, activated carbon and diatomaceous earth is 2-3:2-3:1, and the sum of the mass of activated clay, activated carbon and diatomaceous earth is 3-7% of the mass of the extracted raw material;

[0017] In step 3), the molecular weight cut-off of the ultrafiltration membrane used in ultrafiltration is 3000-5000.

[0018] The present invention provides a medicine or cosmetic comprising the purslane and dendrobium composition, which is obtained by compounding the purslane and dendrobium composition as an active ingredient and adding conventional excipients or auxiliary ingredients acceptable in pharmacy or cosmetics.

[0019] Furthermore, in the medicine or cosmetics, the medicine can be an external preparation. Preferably, the external preparation includes but is not limited to solutions, lotions, emulsions, gels, liniments, or aerosols, etc.; the cosmetics include but are not limited to skin creams, liquids, sprays, emulsions, or ointments, etc.

[0020] The present invention also provides the use of the purslane and dendrobium composition in preparing medicines or cosmetics for improving or treating atopic dermatitis.

[0021] The present invention provides a skin care spray for improving or treating atopic dermatitis, comprising the purslane and dendrobium composition, wherein the skin care spray comprises the following components in percentage by weight:

[0022] 72%-95% water, 2%-15% purslane and dendrobium composition, and 3%-13% glycerin.

[0023] As a preferred embodiment, the above-mentioned skin care spray comprises the following components in percentage by weight:

[0024] 80%-90% water, 6%-13% purslane and dendrobium composition, and 4%-7% glycerin.

[0025] As a most preferred embodiment, the above-mentioned skin care spray comprises the following components in weight percentage:

[0026] 85% water, 9% Portulaca Oleracea Dendrobium composition, and 6% glycerin.

[0027] The skin care spray of the present invention is preferably composed of 15 parts of fresh extract of purslane and 10 parts of fresh extract of dendrobium in the purslane and dendrobium composition.

[0028] The present invention also provides a method for preparing the above-mentioned skin care spray, which comprises the following steps:

[0029] a) Weigh water according to the proportion and sterilize it in a microwave at 70-90°C for 90-150 seconds;

[0030] b) mixing the purslane and dendrobium composition with the sterilized water in step a) (which can be carried out by homogenization for 10-30 min, at a homogenization temperature of 30-50° C. and a stirring speed of 100-300 r / min);

[0031] c) adding glycerol to the mixed solution of step b) and homogenizing for 10-30 minutes, the homogenizing temperature is 30-50°C, and the stirring speed is 100-300r / min. The skin care spray can solve the problems of dry, itchy and red skin caused by the existing lotion spray containing various chemical substances. If necessary, appropriate amounts of auxiliary materials such as moisturizers, emollients, emulsifiers, etc. can be added to make other external preparations suitable for skin, such as toners, lotions, ointments or gels.

[0032] The preparation method of the skin care spray for improving or treating atopic dermatitis provided by the present invention is simple and quick, can effectively soothe and comfort sensitive skin, improve dry, itchy and red skin, and treat atopic dermatitis. The skin care spray of the present invention can quickly replenish water and moisturize, and repair damaged epidermal barriers.

[0033] Compared with the prior art, the present invention has the following beneficial effects:

[0034] The invention is based on the theory of traditional Chinese medicine and modern pharmaceutical technology, and ingeniously scientifically combines two Chinese medicinal materials, purslane and dendrobium, which are both medicinal and edible. Purslane has the effects of clearing away heat and detoxifying, relieving inflammation and relieving itching, while dendrobium has the effects of nourishing yin and moistening dryness, and enhancing immunity. The two can complement each other and improve the therapeutic effect when used in combination.

[0035] The purslane and dendrobium composition of the present invention has the effects of rapidly alleviating skin lesions and relieving itching, can significantly reduce the amount of glucocorticoid ointment used, and avoids side effects caused by long-term external use of glucocorticoid ointment.

[0036] The biologically active ingredients in the purslane and dendrobium of the present invention have anti-inflammatory, anti-oxidative, antibacterial and other effects, are helpful for treating atopic dermatitis, and have significant therapeutic effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] Figure 1 The expression of TNF-α, IL-6, CCL22 and RANTES cytokines was determined experimentally. Note: ****P<0.0001, ***P<0.001, **P<0.01. DETAILED DESCRIPTION

[0038] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0039] In the following examples, the raw materials used are all common commercial products that can be directly purchased, such as pectinase (30000u / g) and protease (50000u / g), purchased from Shanghai MacLean Biochemical Technology Co., Ltd.; cellulase (3500u / g), purchased from Nanjing Dulai Biotechnology Co., Ltd.

[0040] Activated clay (decolorization rate ≥ 98%) and activated carbon (200 mesh) were purchased from Shanghai MacLean Biochemical Technology Co., Ltd.; diatomaceous earth was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.

[0041] Embodiment 1:

[0042] A purslane and dendrobium composition for treating atopic dermatitis consists of the following ingredients in the following weight proportions: 15 parts of purslane fresh extract and 10 parts of dendrobium fresh extract.

[0043] The preparation method of the purslane and dendrobium composition for atopic dermatitis comprises the following steps:

[0044] 1) taking a certain amount of fresh dendrobium or fresh purslane, adding a certain amount of pectinase, protease, cellulase and water, crushing (using a crusher to crush the tissue), grinding with a colloid mill (when grinding, the colloid mill keeps the material temperature at about 40° C.), obtaining a plant slurry, high-speed centrifugation, and taking the supernatant; the mass ratio of pectinase, protease and cellulase is 2:1:3, and the sum of the mass of pectinase, protease and cellulase is 0.9% of the mass of the fresh dendrobium or fresh purslane of the extraction raw material; the amount of water added is 15 times the mass of the fresh dendrobium or fresh purslane of the extraction raw material;

[0045] 2) adding a mixture of activated clay, activated carbon and diatomaceous earth to the supernatant obtained in step 1) at 90° C. and keeping the mixture warm for 20 minutes; centrifuging in a butterfly centrifuge and taking the supernatant; the mass ratio of activated clay, activated carbon and diatomaceous earth is 2:2:1, and the sum of the mass of activated clay, activated carbon and diatomaceous earth is 5% of the mass of the fresh dendrobium or fresh purslane of the extraction raw material;

[0046] 3) ultrafiltration separation of the supernatant obtained in step 2) (the ultrafiltration membrane used for ultrafiltration has a molecular weight cutoff of 3000-5000), collecting the permeate to obtain a fresh extract of purslane or dendrobium (wherein the fresh extract of purslane contains about 5 mg / ml of polysaccharide, and the fresh extract of dendrobium contains about 2 mg / ml of polysaccharide), and mixing the two in proportion.

[0047] A skin care spray for improving atopic dermatitis containing the purslane and dendrobium composition comprises the following raw materials in percentage by weight: 82% of water, 8% of the purslane and dendrobium composition, and 10% of glycerin.

[0048] The preparation method of the above-mentioned skin care spray specifically comprises the following steps:

[0049] (1) Weigh water according to the ratio and sterilize it in a microwave at 80°C for 120 seconds;

[0050] (2) weighing a corresponding proportion of the purslane and dendrobium composition and adding it to the sterilized water in step (1) and homogenizing for 15 minutes at a homogenization temperature of 40° C. and a stirring speed of 200 r / min;

[0051] (3) Weigh glycerol in a corresponding proportion and add it to the mixed solution of step (2) and homogenize for 15 minutes at a homogenization temperature of 40° C. and a stirring speed of 200 r / min to obtain the product.

[0052] Embodiment 2:

[0053] A purslane and dendrobium composition for treating atopic dermatitis consists of the following ingredients in the following weight proportions: 15 parts of purslane fresh extract and 10 parts of dendrobium fresh extract.

[0054] The preparation method of the purslane and dendrobium composition for atopic dermatitis comprises the following steps:

[0055] 1) taking a certain amount of fresh dendrobium or fresh purslane, adding a certain amount of pectinase, protease, cellulase and water, crushing (using a crusher to crush the tissue), grinding with a colloid mill (when grinding, the colloid mill keeps the material temperature at about 40° C.), obtaining a plant slurry, high-speed centrifugation, and taking the supernatant; the mass ratio of pectinase, protease and cellulase is 2:1:3, and the sum of the mass of pectinase, protease and cellulase is 0.9% of the mass of the fresh dendrobium or fresh purslane of the extraction raw material; the amount of water added is 15 times the mass of the fresh dendrobium or fresh purslane of the extraction raw material;

[0056] 2) adding a mixture of activated clay, activated carbon and diatomaceous earth to the supernatant obtained in step 1) at 65° C. and keeping the mixture warm for 50 minutes; centrifuging through a plate and frame filter and taking the supernatant; the mass ratio of activated clay, activated carbon and diatomaceous earth is 2:2:1, and the sum of the mass of activated clay, activated carbon and diatomaceous earth is 5% of the mass of the fresh dendrobium or fresh purslane of the extraction raw material;

[0057] 3) ultrafiltration separation of the supernatant obtained in step 2) (the ultrafiltration membrane used for ultrafiltration has a molecular weight cutoff of 3000-5000), collecting the permeate to obtain a fresh extract of purslane or dendrobium (wherein the fresh extract of purslane contains about 5.6 mg / ml of polysaccharides, and the fresh extract of dendrobium contains about 2.2 mg / ml of polysaccharides), and mixing the two in proportion to obtain the product.

[0058] A skin care spray for improving atopic dermatitis containing the purslane and dendrobium composition comprises the following raw materials in percentage by weight: 85% of water, 5% of the purslane and dendrobium composition, and 10% of glycerin.

[0059] The preparation method of the above-mentioned skin care spray specifically comprises the following steps:

[0060] (1) Weigh a certain amount of water according to the ratio and sterilize it in a microwave at 80°C for 120 seconds;

[0061] (2) weighing a corresponding proportion of the purslane and dendrobium composition and adding it to the sterilized water in step (1) and homogenizing for 15 minutes at a homogenization temperature of 40° C. and a stirring speed of 200 r / min;

[0062] (3) Weigh the corresponding proportion of glycerol and add it to the mixed solution of step (2) and homogenize for 15 minutes at a homogenization temperature of 40° C. and a stirring speed of 200 r / min.

[0063] Embodiment 3:

[0064] A purslane and dendrobium composition for treating atopic dermatitis consists of the following ingredients in the following weight proportions: 15 parts of purslane fresh extract and 10 parts of dendrobium fresh extract.

[0065] The preparation method of the Portulaca Oleracea and Dendrobium officinale composition for atopic dermatitis is described in Example 1.

[0066] A skin care spray for improving atopic dermatitis containing the purslane and dendrobium composition comprises the following raw materials in percentage by weight: 80% of water, 10% of the purslane and dendrobium composition, and 10% of glycerin.

[0067] The preparation method of the above-mentioned skin care spray specifically comprises the following steps:

[0068] (1) Weigh a certain amount of water according to the ratio and sterilize it in a microwave at 80°C for 120 seconds;

[0069] (2) weighing a corresponding proportion of the purslane and dendrobium composition and adding it to the sterilized water in step (1) and homogenizing for 15 minutes at a homogenization temperature of 40° C. and a stirring speed of 200 r / min;

[0070] (3) Weigh the corresponding proportion of glycerol and add it to the mixed solution of step (2) and homogenize for 15 minutes at a homogenization temperature of 40° C. and a stirring speed of 200 r / min.

[0071] Comparative Example 1:

[0072] A skin care spray comprises the following raw materials in percentage by weight: 80% water, 10% purslane fresh extract, and 10% glycerin. The preparation method comprises the following steps:

[0073] (1) Weigh a certain amount of water according to the ratio and sterilize it in a microwave at 80°C for 120 seconds;

[0074] (2) weighing a corresponding amount of purslane fresh extract and adding it to the sterilized water in step (1), and homogenizing for 15 minutes at a homogenization temperature of 40° C. and a stirring speed of 200 r / min;

[0075] (3) Weigh the corresponding proportion of glycerol and add it to the mixed solution of step (2) and homogenize for 15 minutes at a homogenization temperature of 40° C. and a stirring speed of 200 r / min.

[0076] Comparative Example 2:

[0077] A skin care spray comprises the following raw materials in percentage by weight: 80% water, 10% fresh extract of dendrobium officinale, and 10% glycerin. The preparation method comprises the following steps:

[0078] (1) Weigh a certain amount of water according to the ratio and sterilize it in a microwave at 80°C for 120 seconds;

[0079] (2) weighing a corresponding proportion of fresh extract of Dendrobium officinale and adding it to the sterilized water in step (1) and homogenizing for 15 minutes at a homogenization temperature of 40° C. and a stirring speed of 200 r / min;

[0080] (3) Weigh the corresponding proportion of glycerol and add it to the mixed solution of step (2) and homogenize for 15 minutes at a homogenization temperature of 40° C. and a stirring speed of 200 r / min.

[0081] The above embodiments are merely descriptions of preferred implementations of the present invention, and are not intended to limit the concept and scope of the present invention. Without departing from the scheme to which the present invention relates, various obvious modifications and improvements made by those skilled in the art to the technical scheme of the present invention should all fall within the protection scope of the present invention. The technical contents for which the present invention seeks protection are all recorded in the claims.

[0082] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.

[0083] Based on the core innovation of the present invention and the synergistic effect of the mechanism of action, the present invention designed a series of test experiments to evaluate the effectiveness of the solution.

[0084] Experiment 1: Cell experiment

[0085] MSH refers to the Portulaca oleracea and Dendrobium candidum composite, TNF-α refers to tumor necrosis factor α, IFN-γ refers to interferon-γ, CCL22 is also known as macrophage-derived chemokine, and RANTES is also known as chemokine CCL5.

[0086] The specific experimental process is as follows: HACAT cells (purchased from CyBiotech Co., Ltd.) were cultured at 1×10 5 The cells were seeded at a density of 100 μg / mL in a twelve-well plate and divided into three groups, namely the blank control group, the model M group and the MSH group, with three wells of cells in each group, and the volume of the culture medium (DMEM medium containing 10% fetal bovine serum and 1% penicillin-streptomycin, DMEM medium and penicillin-streptomycin purchased from Shanghai Peiyuan Biotechnology Co., Ltd., and fetal bovine serum purchased from Yikesai Biotechnology Co., Ltd.) was 1 mL. After overnight culture, 10 μg MSH was given to the cells in the MSH group, and 100 μL PBS buffer was given to the other two groups. After 1 hour of culture, 1 μL of TNF-α and IFN-γ were given to the M group and the MSH group, respectively, at a concentration of 10 μg / mL. After continuing to culture for 23 hours, RNA was extracted, reverse transcribed into cDNA, and the expression changes of chemokines (TNF-α, IL-6, CCL22 and RANTES) in each group were determined by RT-qPCR.

[0087] The MSH group used the Portulaca oleracea and Dendrobium officinale composition prepared in Example 2 as a sample to perform experiments and measure the expression of TNF-α, IL-6, CCL22 and RANTES cytokines. The specific results are shown in Figure 1 . Figure 1 It can be seen that the expressions of TNF-α, IL-6, CCL22 and RANTES in the model group M were upregulated, while those in the Portulaca oleracea and Dendrobium combination MSH group were improved compared with the M group.

[0088] Atopic dermatitis is related to the expression of chemokines, and the expression of chemokines in the atopic dermatitis cell model is higher than that in normal cells. Therefore, the above results show that the Portulaca Oleracea Dendrobium candidum composition has the effect of alleviating atopic dermatitis.

[0089] Experiment 2: Clinical effect test of the composition of the present invention

[0090] 1. Clinical data

[0091] A total of 150 patients with atopic dermatitis (dry skin, redness, and itching symptoms) were selected.

[0092] 1.1 Inclusion criteria

[0093] ① Patients diagnosed with atopic dermatitis have symptoms of dry, red, and itchy skin;

[0094] ②The patient’s age is between 18 and 45 years old.

[0095] 1.2 Exclusion criteria

[0096] ① Those who do not meet the inclusion criteria;

[0097] ② Patients and their families refuse to cooperate with treatment;

[0098] ③ Those with allergic constitution or known allergy to the ingredients of this drug;

[0099] ④ Patients who are participating in clinical trials of other drugs.

[0100] 2. Treatment methods

[0101] The patients were randomly divided into 5 groups, each with 30 cases, and each group was further randomly divided into 3 subgroups, each with 10 cases. The 5 groups of patients used the skin care spray prepared by Examples 1 to 3 of the present invention and Comparative Examples 1 to 2 for 15 days. Usage: Spray the spray evenly on the affected area after washing the face in the morning and evening every day.

[0102] 3. Efficacy determination and treatment results

[0103] The efficacy evaluation and treatment effects of various examples and comparative examples in improving atopic dermatitis are shown in Tables 1 to 3. Total effective rate = (number of markedly effective cases + number of effective cases) / total number of cases × 100%.

[0104] Table 1 below shows the efficacy determination method and treatment effect of each embodiment and comparative example for the treatment of dry skin (dryness and / or irritation) of atopic dermatitis.

[0105] Table 1. Methods for determining the therapeutic effect and therapeutic effect of each embodiment and comparative example for treating atopic dermatitis with dry skin

[0106]

[0107]

[0108] Different letters in the table represent significant differences, P < 0.05.

[0109] Table 2 below shows the efficacy determination method and treatment effect of each embodiment and comparative example for the treatment of skin redness of atopic dermatitis.

[0110] Table 2. Methods for determining the therapeutic efficacy and therapeutic effects of each embodiment and comparative example for treating atopic dermatitis with skin redness

[0111]

[0112]

[0113] Different letters in the table represent significant differences, P < 0.05.

[0114] Table 3 below shows the efficacy determination method and therapeutic effect of each embodiment and comparative example for treating the symptom of atopic dermatitis skin itching.

[0115] Table 3. Methods for determining the therapeutic effect and therapeutic effect of each embodiment and comparative example for treating atopic dermatitis with itchy skin

[0116]

[0117]

[0118]

[0119] Different letters in the table represent significant differences, P < 0.05.

[0120] The above test results show that the purslane and dendrobium composition of the present invention has a good therapeutic effect on various symptoms of atopic dermatitis, and can effectively improve or treat symptoms such as dry skin, redness and itching, and compared with the use of single-flavor drugs, the purslane and dendrobium composition has a synergistic effect. As shown in Tables 1 to 3, statistical analysis was performed by One-way ANOVA, and there were significant differences between the embodiments and the comparative examples, indicating that the purslane and dendrobium composition of the present invention can effectively improve or treat atopic dermatitis. Among them, Example 1 (the weight ratio of purslane extract to dendrobium extract is 3:2, and the amount of purslane and dendrobium composition added in the skin care spray is 8%) is higher than that of Example 2 in treating dry skin, redness and itching, and there is no significant difference between the effects of Example 1 and Example 3 (Example 3 is slightly better than Example 1). Considering the cost factor, it is recommended to select the addition amount of the purslane and dendrobium composition as 8%.

[0121] In summary, the composition of the present invention is simple and low in cost; and the various medicinal ingredients are properly matched, which has a good improvement and treatment effect on atopic dermatitis, and can effectively improve and treat symptoms such as dryness, redness and itching of the skin; compared with single-flavor drugs, the composition of the present invention has a synergistic effect. The weight ratio of the purslane extract to the dendrobium extract is 3:2, and the effect is best when the amount of the purslane and dendrobium composition added in the skin care spray is 8-10%. The composition of the present invention can be used to prepare medicines or cosmetics for improving or treating dry skin, and has good application prospects.

Claims

1. A purslane and dendrobium composition for atopic dermatitis, characterized in that: The invention is composed of the following ingredients in proportions by weight: 10-50 parts of fresh extract of purslane and 5-30 parts of fresh extract of dendrobium.

2. The purslane and dendrobium composition for atopic dermatitis according to claim 1, characterized in that: The invention is composed of the following ingredients in proportions by weight: 15-35 parts of fresh extract of purslane and 10-15 parts of fresh extract of dendrobium.

3. The purslane and dendrobium composition for atopic dermatitis according to claim 1, characterized in that: The invention is composed of the following ingredients in the following weight proportions: 15 parts of fresh extract of purslane and 10 parts of fresh extract of dendrobium.

4. The method for preparing the Portulaca Oleracea and Dendrobium composition for atopic dermatitis according to any one of claims 1 to 3, characterized in that: The steps include: 1) Take a certain amount of fresh dendrobium or fresh purslane, add a certain amount of pectinase, protease, cellulase and water, crush and grind to obtain plant slurry, separate the solid and liquid, and take the supernatant; 2) Adding a mixture of activated clay, activated carbon and diatomaceous earth to the supernatant obtained in step 1) at 60-100° C. and keeping the temperature for 10-60 minutes; separating the solid and the liquid and taking the supernatant; 3) The supernatant obtained in step 2) is separated by ultrafiltration, and the permeate is collected to obtain the fresh extract of purslane or dendrobium, and the two are mixed in proportion to obtain the fresh extract.

5. The method for preparing the Portulaca Oleracea and Dendrobium composition for atopic dermatitis according to claim 4, characterized in that: In step 1), the mass ratio of pectinase, protease and cellulase is 2-3:1:2-3, and the sum of the mass of pectinase, protease and cellulase is 0.7-0.9% of the mass of the extracted raw material; In step 2), the mass ratio of activated clay, activated carbon and diatomaceous earth is 2-3:2-3:1, and the sum of the mass of activated clay, activated carbon and diatomaceous earth is 3-7% of the mass of the extracted raw material; In step 3), the molecular weight cut-off of the ultrafiltration membrane used in ultrafiltration is 3000-5000.

6. A medicine or cosmetic comprising the Portulaca oleracea and Dendrobium officinale composition according to any one of claims 1 to 3, characterized in that: The purslane and dendrobium composition is taken as an active ingredient, and conventional excipients or auxiliary ingredients acceptable in pharmacy or cosmetics are added to prepare the composition.

7. The medicine or cosmetic according to claim 6, characterized in that The medicine is an external preparation, which is a solution, lotion, emulsion, gel, liniment, or aerosol; the cosmetic is a skin cream, liquid, spray, emulsion, or ointment.

8. Use of the Portulaca oleracea and Dendrobium officinale composition according to any one of claims 1 to 3 in the preparation of a medicament or cosmetic for improving or treating atopic dermatitis.

9. A skin care spray for improving or treating atopic dermatitis comprising the Portulaca oleracea and Dendrobium candidum composition according to any one of claims 1 to 3, characterized in that: The skin care spray comprises the following components in percentage by weight: 72%-95% water, 2%-15% purslane and dendrobium composition, and 3%-13% glycerin.

10. A method for preparing the skin care spray according to claim 9, characterized in that: The following steps are involved: a) Weigh water according to the proportion and sterilize it under microwave; b) mixing the purslane and dendrobium composition with the sterilized water in step a); c) adding glycerol to the mixed solution of step b) and homogenizing at a homogenization temperature of 30-50° C. to obtain the product.

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