Full-automatic cleaning and disinfecting device and method for pharmaceutical production equipment

Abstract

The invention relates to the technical field of medicine production equipment maintenance, in particular to a full-automatic cleaning and disinfecting device and method for medicine production equipment, which can overcome the defect that the arc surface of the bottom of a container cannot be effectively irradiated by traditional ultraviolet disinfection, and improve the disinfection effect and reliability. Comprising a main body support which is independently and fixedly arranged; the reaction kettle is internally provided with a cavity, and the bottom end of the reaction kettle is communicated with a kettle body output pipe; the lifting mechanism comprises a lifting cross beam vertically sliding on the main body bracket; the cleaning mechanism is rotationally mounted on the lifting cross beam and used for conveying cleaning water and cleaning gas; the disinfection mechanism is arranged on the cleaning mechanism and is used for disinfecting the reaction kettle; the rotating assembly is arranged on the lifting cross beam and used for driving the cleaning mechanism to rotate; the waste discharge mechanism is fixedly mounted on the main body bracket, is communicated with the kettle body output pipe and is used for receiving waste liquid and waste gas; the disinfection mechanism further comprises a hoisting pipe which is arranged on the cleaning mechanism in a sliding mode.

Description

Technical Field

[0001] The present invention relates to the technical field of maintenance of pharmaceutical production equipment, and in particular to a fully automatic cleaning and disinfecting device and method for pharmaceutical production equipment. Background Art

[0002] In the pharmaceutical manufacturing industry, the cleaning and disinfection of production equipment is a key link to ensure the quality and safety of drugs. In particular, the reactor, as the core equipment in the pharmaceutical production process, its internal cleanliness and sterility directly determine the quality of the final product. However, traditional cleaning and disinfection methods have many shortcomings, which seriously restrict the further improvement of production efficiency and product quality.

[0003] Traditional cleaning methods often rely on manual operation, using high-pressure water guns or brushes to flush the inner wall of the reactor, which is not only inefficient, but also difficult to ensure comprehensive and uniform cleaning. At the same time, manual cleaning also has safety hazards, and operators may be harmed by contact with harmful substances. In addition, some stubborn stains and residues are often difficult to remove by simple flushing, resulting in poor cleaning results.

[0004] In terms of disinfection, although traditional ultraviolet disinfection has a certain bactericidal effect, its application scope and effect are subject to many limitations. First of all, ultraviolet disinfection can usually only disinfect the surface of the equipment. For the dead corners and hard-to-reach areas inside the equipment, such as the arc surface at the bottom of the reactor, ultraviolet rays often cannot effectively irradiate, resulting in incomplete disinfection and difficulty in achieving the ideal disinfection effect. Summary of the invention

[0005] In order to solve the above technical problems, the present invention provides a fully automatic cleaning and disinfection device and method for pharmaceutical production equipment, which can overcome the defect that traditional ultraviolet disinfection cannot effectively irradiate the arc surface of the bottom of the container and improve the disinfection effect and reliability.

[0006] The fully automatic cleaning and disinfecting device for pharmaceutical production equipment of the present invention comprises:

[0007] Main frame, independently fixed;

[0008] The reactor has a chamber disposed inside, and the bottom of the reactor is connected to a reactor output pipe;

[0009] A lifting mechanism, including a lifting beam that slides vertically on the main support;

[0010] The cleaning mechanism is rotatably mounted on the lifting beam and is used to transport cleaning water and cleaning gas;

[0011] A disinfection mechanism, arranged on the cleaning mechanism, for disinfecting the reaction kettle;

[0012] A rotating assembly is arranged on the lifting beam and is used to drive the cleaning mechanism to rotate;

[0013] The waste discharge mechanism is fixedly mounted on the main support and connected to the kettle output pipe to receive waste liquid and waste gas;

[0014] Among them, disinfection agencies also include:

[0015] A hanging pipe is slidably arranged on the cleaning mechanism;

[0016] The downward pressing frame is fixedly mounted on the hanging pipe;

[0017] Two guide slides are symmetrically mounted on the cleaning mechanism, a plurality of ultraviolet lamp assemblies are slidably arranged in the guide slides, and the ultraviolet lamp assemblies include guide sliders slidably mounted in the guide slides, and upper and lower end surfaces of the guide sliders are both arranged as inclined surfaces; a connecting plate is also included, which is fixedly connected to the guide sliders; and an ultraviolet lamp is also included, which is fixedly connected to the connecting plate;

[0018] A plurality of top springs, fixedly connected to the connecting plates, and used to connect adjacent connecting plates;

[0019] Adjacent guide slide blocks are hinged to each other.

[0020] The fully automatic cleaning and disinfecting device for pharmaceutical production equipment of the present invention has two lifting mechanisms, which are respectively arranged at the two ends of the lifting beam, and the lifting mechanisms include:

[0021] The cylinder is fixedly mounted on the main support;

[0022] The telescopic rod is driven by a cylinder to move up and down;

[0023] A transmission arm, the top end of which is hinged to the telescopic rod;

[0024] A lifting slider is slidably installed in the main frame and fixedly connected to the lifting beam;

[0025] The linkage slider slides on the bottom surface of the lifting beam; the bottom end of the transmission arm is hinged with the linkage slider;

[0026] A first tension spring is arranged between the linkage slider and the lifting slider;

[0027] A bearing ring is mounted on the cleaning mechanism;

[0028] The linkage plate has two ends which are respectively hinged to the linkage slider and the bearing ring.

[0029] In the fully automatic cleaning and disinfecting device for medicine production equipment of the present invention, two lampshade plates are symmetrically fixedly mounted on each ultraviolet lamp, and an optical film is arranged on the inner end surface of the lampshade plate.

[0030] The fully automatic cleaning and disinfecting device for medicine production equipment of the present invention has a lampshade plate that is arranged as a "Z"-shaped plate.

[0031] The fully automatic cleaning and disinfecting device for pharmaceutical production equipment of the present invention, the cleaning mechanism comprises:

[0032] The jet pipe is rotatably mounted on the lifting beam, and a jet port is provided at the bottom thereof, and the jet port is arranged in a wide-mouth shape;

[0033] The liquid spray pipe is fixedly inserted in the air jet pipe, and a liquid spray port is arranged at the bottom thereof, the liquid spray port is arranged in a wide-mouth shape, and a ventilation cavity is arranged between the liquid spray pipe and the air jet pipe;

[0034] The air intake hose is connected to the air injection pipe and is used to transport high-pressure gas.

[0035] The fully automatic cleaning and disinfecting device for pharmaceutical production equipment of the present invention, the cleaning mechanism also includes:

[0036] A liquid inlet hose, connected to the liquid spray pipe, for conveying cleaning liquid;

[0037] A first cross beam is fixedly mounted inside the liquid spray pipe, and a second tension spring is hooked and mounted on the bottom end;

[0038] The liquid spraying inner tube is slidably arranged at the bottom end of the liquid spraying tube, a second cross beam is fixedly installed inside the tube, the bottom end of the second tension spring is fixedly connected to the second cross beam, the second tension spring is used to pull the liquid spraying inner tube, and a third tension spring is hooked and installed at the bottom end of the second cross beam;

[0039] The pipe plug is slidably arranged at the bottom end of the liquid spraying inner tube, the top end of the pipe plug is arranged in a cone shape, the top end of the pipe plug is fixedly connected to the bottom end of the third tension spring, and the third tension spring is used to pull the pipe plug so that the pipe plug is inserted into the liquid spraying inner tube.

[0040] The fully automatic cleaning and disinfecting device for pharmaceutical production equipment of the present invention, the rotating assembly comprises:

[0041] The motor is fixedly mounted on the lifting beam, and a driving gear is fixedly mounted on the output end of the motor;

[0042] The gear ring is fixedly sleeved on the outer wall of the jet pipe and meshes with the driving gear;

[0043] The turntable is rotatably mounted on the top of the main support, and the tops of the air inlet hose and the liquid inlet hose are fixedly clamped on the turntable.

[0044] The fully automatic cleaning and disinfecting device for pharmaceutical production equipment of the present invention, the waste discharge mechanism comprises:

[0045] The cover is slidably arranged on the main body bracket, and an interface is arranged at the top thereof, which is connected with the output pipe of the kettle body, and a waste discharge pipe is arranged at the bottom of the cover;

[0046] The connecting pipe is fixedly installed inside the housing, and a plurality of vents are arranged on the upper part thereof.

[0047] The air bag is fixedly mounted on the connecting pipe and covers the vent;

[0048] The slide plate is slidably installed between the connecting pipe and the cover shell, and an independent air chamber is above the slide plate.

[0049] The fully automatic cleaning and disinfecting device for pharmaceutical production equipment of the present invention, the waste discharge mechanism also includes:

[0050] A driven gear is rotatably mounted at the bottom of the housing to control the sliding plate to slide up and down;

[0051] Two linkage rods are symmetrically arranged between the driven gear and the slide plate, the bottom end of the linkage rod is ball-connected with the driven gear, and the top end of the linkage rod is ball-connected with the bottom end of the slide plate;

[0052] The adjusting assembly is arranged on the outer side wall of the housing and is used for driving the driven gear to rotate.

[0053] The fully automatic cleaning and disinfection method for pharmaceutical production equipment of the present invention comprises the following steps:

[0054] Place the reactor to be cleaned and disinfected in the cleaning and disinfection device;

[0055] Start the cleaning and disinfection device, introduce high-pressure gas to purge the residues and impurities inside the reactor, introduce cleaning liquid to cover every corner inside the reactor, let the cleaning liquid stay inside the equipment, and dissolve and soften the stubborn stains and residues;

[0056] The cleaning liquid and dissolved waste are discharged, and high-pressure gas is introduced to purge the interior of the reactor to remove water droplets and impurities;

[0057] Close the liquid and air inlets, and use ultraviolet rays to irradiate the interior of the reactor in all directions to kill bacteria and viruses inside the reactor.

[0058] Compared with the prior art, the present invention has the following beneficial effects:

[0059] By integrating the lifting mechanism, cleaning mechanism, disinfection mechanism, rotating assembly and waste discharge mechanism, efficient and automated cleaning and disinfection of the reactor is achieved, which not only improves production efficiency but also reduces manual intervention, lowers operational risks and costs; the UV lamp assembly in the disinfection mechanism slides on the cleaning mechanism through a guide groove and is flexibly adjusted with the help of a lifting pipe and a downward pressure frame, and can be evenly distributed throughout the reactor, ensuring comprehensive disinfection of the reactor including the bottom arc surface; it overcomes the defect that traditional ultraviolet disinfection cannot effectively irradiate the bottom arc surface of the container, and improves the disinfection effect and reliability. BRIEF DESCRIPTION OF THE DRAWINGS

[0060] The present invention will be further described below in conjunction with the accompanying drawings.

[0061] Figure 1 It is a schematic diagram of the structure of the present invention;

[0062] Figure 2 It is a schematic diagram of the enlarged structure of the reactor;

[0063] Figure 3 It is a schematic diagram of the connection structure of the lifting mechanism, the disinfection mechanism and the cleaning mechanism;

[0064] Figure 4 It is a schematic diagram of the connection structure between the lifting mechanism and the disinfection mechanism;

[0065] Figure 5 It is a schematic diagram of the arrangement structure of the UV lamp components;

[0066] Figure 6 It is a schematic diagram of the cross-sectional structure of the cleaning mechanism;

[0067] Figure 7 It is an enlarged structural diagram of the waste discharge mechanism;

[0068] Figure 8 It is a schematic diagram of the cross-sectional structure of the waste discharge mechanism;

[0069] Markings in the attached drawings: 1, main frame; 2, reactor; 21, reactor output pipe; 3, lifting mechanism; 31, cylinder; 32, telescopic rod; 33, transmission arm; 34, linkage slider; 35, lifting beam; 36, lifting slider; 37, first tension spring; 38, linkage plate; 39, bearing ring; 4, disinfection mechanism; 41, lifting pipe; 42, pressing frame; 43, guide slide; 44, guide slider; 45, connecting plate; 46, ultraviolet lamp; 47, first top spring; 48, lampshade plate; 5, cleaning mechanism; 5a, jet pipe; 5b, Liquid spray pipe; 5c, air intake hose; 51, liquid intake hose; 52, first cross beam; 53, second tension spring; 54, second cross beam; 55, liquid spray inner tube; 56, third tension spring; 57, pipe plug; 6, rotating assembly; 61, motor; 62, driving gear; 63, gear ring; 64, turntable; 7, waste discharge mechanism; 7a, fixed locking sleeve; 7b, adjusting rod; 7c, fourth tension spring; 7d, driving gear; 7e, sleeve; 71, cover; 72, connecting pipe; 73, airbag; 74, slide plate; 75, linkage rod; 76, driven gear. DETAILED DESCRIPTION

[0070] The specific implementation of the present invention is further described in detail below in conjunction with the accompanying drawings and examples. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0071] like Figures 1 to 8As shown, the fully automatic cleaning and disinfecting device for pharmaceutical production equipment of the present invention comprises:

[0072] The main frame 1 is independently fixed and provides a supporting foundation for the entire device;

[0073] The reactor 2 has a chamber disposed therein, the side wall of the chamber of the reactor 2 has a cylindrical straight wall and an arc-shaped bottom cylindrical wall, and the bottom end of the reactor 2 is connected to a reactor output pipe 21;

[0074] A lifting mechanism 3, comprising a lifting beam 35 that slides vertically on the main frame 1;

[0075] The cleaning mechanism 5 is rotatably mounted on the lifting beam 35 and is used to transport cleaning water and cleaning air; it is connected to an external high-pressure water pump and a high-pressure air pump;

[0076] A disinfection mechanism 4, arranged on the cleaning mechanism 5, for disinfecting the reaction kettle 2;

[0077] The rotating assembly 6 is arranged on the lifting beam 35, and is used to drive the cleaning mechanism 5 to rotate; when cleaning and disinfecting the cylinder wall of the chamber of the reactor 2, it is necessary to rotate, spray and irradiate, so it is necessary to control the rotation of the cleaning mechanism 5, and the rotating cleaning mechanism 5 will drive the disinfection mechanism 4 to rotate as a whole, so as to achieve all-round cleaning and irradiation of the cylinder wall of the chamber of the reactor 2;

[0078] The waste discharge mechanism 7 is fixedly mounted on the main support 1 and communicated with the kettle output pipe 21 for receiving waste liquid and waste gas;

[0079] The specific working process of this device is as follows:

[0080] After the pharmaceutical operation is completed, the cylinder wall of the chamber of the reactor 2 needs to be cleaned and disinfected by cleaning liquid, high-pressure jet and ultraviolet light; when cleaning the reactor 2, the reactor 2 is hoisted as a whole to the main support 1, and the lifting mechanism 3 is lowered until the disinfection mechanism 4 and the cleaning mechanism 5 extend into the interior of the reactor 2; the cleaning mechanism 5 is connected to an external high-pressure water pump and a high-pressure air pump, and the high-pressure water and air are transported and sprayed into the interior of the chamber of the reactor 2, and the cleaning mechanism 5 performs a flushing operation; the disinfection mechanism 4 realizes the function of disinfecting the cylinder wall of the chamber of the reactor 2, and cleans the cylinder wall of the chamber of the reactor 2 During cleaning and disinfection, rotational spraying and irradiation are required, so it is necessary to control the rotation of the cleaning mechanism 5. The rotating cleaning mechanism 5 will drive the disinfection mechanism 4 to rotate as a whole, so as to achieve all-round cleaning and irradiation of the chamber wall of the reactor 2; when cleaning and disinfecting the reactor 2, it is necessary to keep the chamber of the reactor 2 sealed to prevent the overflow of cleaning liquid, gas and ultraviolet light, so both gas and liquid need to be discharged through the reactor output pipe 21, and the waste discharge mechanism 7 is connected to the reactor output pipe 21, and the waste discharge mechanism 7 is connected to the external negative pressure pump to extract the waste liquid and waste gas to prevent pollution of the working environment

[0081] The disinfection mechanism 4 can be realized by existing technologies such as air cylinders and telescopic electric push cylinders, but these existing technologies can only realize simple pushing functions. Since the arc-shaped bottom wall of the chamber of the reactor 2 needs to be disinfected in the present device, in order to solve the above problem, the present device designs a better disinfection mechanism 4, including:

[0082] A hanging pipe 41 is slidably arranged on the cleaning mechanism 5;

[0083] The pressing frame 42 is fixedly mounted on the hanging pipe 41;

[0084] Two guide slide grooves 43 are symmetrically mounted on the cleaning mechanism 5. A plurality of ultraviolet lamp assemblies are slidably arranged in the guide slide grooves 43. The ultraviolet lamp assembly includes a guide slider 44, which is slidably mounted in the guide slide grooves 43. Both upper and lower end surfaces of the guide slider 44 are arranged as inclined surfaces; a connecting plate 45 is fixedly connected to the guide slider 44; and an ultraviolet lamp 46 is fixedly connected to the connecting plate 45.

[0085] A plurality of top springs 47, fixedly connected to the connecting plates 45, and used to connect adjacent connecting plates 45;

[0086] Adjacent guide sliders 44 are hinged to each other; both upper and lower end surfaces of the guide slider 44 are set as inclined surfaces, that is, the cross section of the guide slider 44 is a trapezoid, and the hinge points of adjacent guide sliders 44 are the corners of the long sides of the trapezoid;

[0087] The working process and principle of the disinfection mechanism 4 are as follows: when the disinfection mechanism 4 is at the highest point, each group of ultraviolet lamps 46 are arranged vertically to irradiate the vertical section of the chamber wall. When the lifting beam 35 moves down to the lowest point, the telescopic rod 32 is continuously controlled to move downward, which will drive the hoisting tube 41 to slide downward as a whole. Then, under the action of the hoisting tube 41 pushing downward, the pressing frame 42 will be driven to press down, and the pressing frame 42 will push all the ultraviolet lamp components to slide downward. When the ultraviolet lamp components slide downward, they will slide out of the guide groove 43 in an orderly manner starting from the lowest group.

[0088] The ultraviolet lamp assembly slides out of the guide slot 43, that is, the guide slider 44 slides out of the guide slot 43. When the guide slider 44 is inside the guide slot 43, under the restriction of the guide slot 43, each group of guide sliders 44 will be arranged vertically, so each group of connecting plates 45 and ultraviolet lamps 46 installed on the guide slider 44 will also be arranged vertically. At this time, the ultraviolet lamp assembly is arranged in the vertical direction to vertically irradiate the cylinder wall of the chamber of the reactor 2, corresponding to the vertical section cylinder wall of the chamber. When each guide slider 44 slides out from the bottom end of the guide slot 43 in turn, the guide slider 44 that slides out is separated from the restriction of the guide slot 43, and then under the elastic force of the top spring 47 and the hinged action of the adjacent guide slider 44, the guide slider 44 below is pushed to swing, and then the guide slider 44 With the cooperation of the inclined surfaces at the upper and lower ends, the swinging angle of the swinging guide slider 44 can be limited. At this time, the swinging guide slider 44 will drive the ultraviolet lamp 46 installed thereon to swing to the same angle. Except for the ultraviolet lamp assembly in the top group, all other ultraviolet lamp assemblies slide out of the guide slide groove 43. The upper and lower end surfaces of each guide slider 44 are spliced ​​end to end into an arc shape. Correspondingly, each ultraviolet lamp 46 will also be arranged in an arc. At the same time, since the lifting beam 35 has been moved down to the lowest point, each ultraviolet lamp assembly is also at the bottom of the chamber of the reactor 2. The arc-shaped ultraviolet lamp assembly disinfects the arc-shaped bottom cylinder wall of the chamber, overcoming the defect that traditional ultraviolet disinfection cannot effectively irradiate the arc surface of the bottom of the container, thereby improving the disinfection effect and reliability.

[0089] like Figure 3 to Figure 4 As shown, two lifting mechanisms 3 are provided, which are respectively provided at the two ends of the lifting beam 35. The lifting mechanism 3 includes:

[0090] The cylinder 31 is fixedly mounted on the main frame 1;

[0091] The telescopic rod 32 is driven by the cylinder 31 to move up and down;

[0092] The transmission arm 33 has a top end hinged to the telescopic rod 32;

[0093] A lifting slider 36 is slidably mounted in the main frame 1 and fixedly connected to the lifting beam 35;

[0094] The linkage slider 34 slides on the bottom surface of the lifting beam 35; the bottom end of the transmission arm 33 is hinged to the linkage slider 34;

[0095] A first tension spring 37 is provided between the linkage slider 34 and the lifting slider 36;

[0096] The bearing ring 39 is mounted on the cleaning mechanism 5;

[0097] The linkage plate 38 has two ends hinged to the linkage slider 34 and the bearing ring 39 respectively;

[0098] The working process and principle of the lifting mechanism 3 are as follows: the lifting beam 35 is slidably arranged in the main frame 1 through two sets of lifting sliders 36. When the telescopic rod 32 is in the initial position, the lifting beam 35 will be at the highest point, and the disinfection mechanism 4 and the cleaning mechanism 5 are also at the highest point. When it is necessary to adjust the height of the disinfection mechanism 4 and the cleaning mechanism 5, the cylinder 31 is started to control the telescopic rod 32 at its output end to extend downward. At this time, under the tension of the first tension spring 37, the linkage slider 34 is always close to the lifting slider 36, and then the lifting beam 35 is passed through the two sets of lifting sliders 36 as a whole. Slide downward smoothly, thereby moving the disinfection mechanism 4 and the cleaning mechanism 5 downward. When the lifting beam 35 moves down to the lowest point, continue to control the telescopic rod 32 to move downward. At this time, the transmission arm 33 hinged to the telescopic rod 32 will start to swing under the action of pressure, and the swinging transmission arm 33 is hinged to the linkage slider 34. Since the linkage slider 34 is slidingly arranged at the bottom of the lifting beam 35, the linkage slider 34 will slide toward the middle under the driving action of the transmission arm 33, and the sliding linkage slider 34 is hinged to the linkage plate 38, so that the linkage plate 38 swings, and then the swinging linkage plate 38 drives the hoisting pipe 41 to slide downward as a whole.

[0099] like Figure 5 As shown, two lampshade plates 48 are symmetrically fixedly installed on each ultraviolet lamp 46, and an optical film is provided on the inner end surface of the lampshade plate 48; the optical film can reflect ultraviolet rays, reduce the scattering and absorption of light, and make more ultraviolet energy concentrated on the area that needs to be disinfected, thereby improving the disinfection effect; the optical film can make the ultraviolet distribution more uniform, avoid the problem of incomplete disinfection of some areas due to uneven light, and ensure that the entire reactor can be effectively disinfected; because the optical film improves the utilization efficiency of ultraviolet rays, it can achieve better disinfection effect at the same power, or use lower power lamps when achieving the same disinfection effect, thereby saving energy.

[0100] like Figure 5 As shown, the lampshade plate 48 is configured as a "Z" shaped plate; the "Z" shaped design allows the lampshade plates to be closely arranged, and the gap between each group of lampshade plates is optimized, thereby avoiding physical interference between the lampshade plates and ensuring that each ultraviolet lamp assembly can work normally without affecting performance due to mutual squeezing or collision.

[0101] like Figure 4 and Figure 6 As shown, the cleaning mechanism 5 includes:

[0102] The jet pipe 5a is rotatably mounted on the lifting beam 35, and has a jet outlet at the bottom thereof, which is configured to be wide-mouthed;

[0103] The liquid spraying pipe 5b is fixedly inserted in the air jet pipe 5a, and a liquid spraying port is provided at the bottom thereof, and the liquid spraying port is provided in a wide-mouth shape, and a ventilation cavity is provided between the liquid spraying pipe 5b and the air jet pipe 5a;

[0104] An air intake hose 5c, connected to the air injection pipe 5a, for delivering high-pressure gas;

[0105] The gas enters the ventilation cavity through the air inlet hose 5c, and then the ventilation cavity sprays the high-pressure gas into the chamber of the reactor 2. Under the coordinated action of the gas jet and the liquid spray port, the gas is sprayed into the chamber of the reactor 2 in a divergent ring shape, increasing the gas spray area and improving the cleaning effect.

[0106] like Figure 6 As shown, the cleaning mechanism 5 also includes:

[0107] A liquid inlet hose 51 is connected to the liquid spraying pipe 5b and is used to transport the cleaning liquid;

[0108] The first cross beam 52 is fixedly mounted inside the liquid spraying pipe 5b, and a second tension spring 53 is hooked and mounted on the bottom end;

[0109] The liquid spraying inner tube 55 is slidably arranged at the bottom end of the liquid spraying tube 5b, and a second cross beam 54 is fixedly installed inside the liquid spraying inner tube 55. The bottom end of the second tension spring 53 is fixedly connected to the second cross beam 54. The second tension spring 53 is used to pull the liquid spraying inner tube 55. The bottom end of the second cross beam 54 is hooked with a third tension spring 56.

[0110] The pipe plug 57 is slidably disposed at the bottom end of the liquid spraying inner tube 55. The top end of the pipe plug 57 is configured to be conical. The top end of the pipe plug 57 is fixedly connected to the bottom end of the third tension spring 56. The third tension spring 56 is used to pull the pipe plug 57 so that the pipe plug 57 is inserted into the liquid spraying inner tube 55.

[0111] The working process and principle of the cleaning mechanism 5 are as follows: the high-pressure liquid is transported into the liquid spray pipe 5b through the liquid inlet hose 51. Due to their own shapes, the first crossbeam 52 and the second crossbeam 54 are subjected to negligible liquid pressure. The pipe plug 57 is the main body that withstands the water pressure. At this time, the force exerted on the third tension spring 56 includes the weight of the pipe plug 57 and the water pressure. The force exerted on the second tension spring 53 includes the weight of the second crossbeam 54, the liquid spray inner tube 55, the third tension spring 56 and the pipe plug 57 as well as the water pressure. Therefore, the second tension spring 53 will be stretched before the third tension spring 56, causing the liquid spray inner tube 55 to slide downward. When the second tension spring 53 is stretched to the limit under the action of the water pressure, the water pressure continues to impact the pipe plug 57. As the water As the pressure increases, the pipe plug 57 will slide out of the liquid spraying inner tube 55, and the liquid will be sprayed out through the liquid spraying inner tube 55. During the spraying, the liquid is sprayed into the chamber of the reactor 2 in a divergent ring shape through the guidance of the cone at the top of the pipe plug 57. When the liquid is discharged through the liquid spraying inner tube 55, due to the decrease in water pressure, the second tension spring 53 will drive the liquid spraying inner tube 55 to slide upward as a whole, and at the same time, the liquid spraying position will be moved upward. Then, as the water pressure is released, until the water pressure is insufficient to overcome the tension of the third tension spring 56, the pipe plug 57 will retreat and be inserted into the liquid spraying inner tube 55 to continue to transport the liquid. The pressure rises, and the above-mentioned spraying action is repeated, so that the liquid can be sprayed into the chamber of the reactor 2 reciprocatingly up and down, thereby improving the cleaning effect.

[0112] like Figure 3 to Figure 4 As shown, the rotating assembly 6 includes:

[0113] The motor 61 is fixedly mounted on the lifting beam 35, and a driving gear 62 is fixedly mounted on its output end;

[0114] The gear ring 63 is fixedly sleeved on the outer wall of the jet pipe 5a and meshes with the driving gear 62;

[0115] A turntable 64 is rotatably mounted on the top of the main support 1, and the tops of the air inlet hose 5c and the liquid inlet hose 51 are fixedly mounted on the turntable 64;

[0116] The working process and principle of the rotating component 6 are as follows: when cleaning the chamber of the reactor 2, it is necessary to clean it in all directions, so the cleaning liquid, gas and ultraviolet light all need to rotate, start the motor 61, drive the gear 62 and the gear ring 63 to drive the cleaning mechanism 5 to rotate on the lifting beam 35 as a whole. During the rotation, the air inlet hose 5c and the liquid inlet hose 51 rotate synchronously with the assistance of the turntable 64, and the disinfection mechanism 4 as a whole will also rotate together, realizing the comprehensive cleaning and disinfection functions of the liquid, gas and ultraviolet light, and improving the cleaning and disinfection effect.

[0117] like Figures 7 and 8 As shown, the waste discharge mechanism 7 includes:

[0118] The cover shell 71 is slidably disposed on the main frame 1, and an interface is disposed at the top thereof, which is connected to the kettle output pipe 21, and a waste discharge pipe is disposed at the bottom of the cover shell 71;

[0119] The connecting pipe 72 is fixedly installed inside the housing 71, and a plurality of vents are provided on the upper part thereof.

[0120] The air bag 73 is fixedly mounted on the connecting pipe 72 and covers the vent;

[0121] The slide plate 74 is slidably mounted between the connecting pipe 72 and the cover 71, and an independent air chamber is formed above the slide plate 74;

[0122] A driven gear 76 is rotatably mounted at the bottom of the housing 71 to control the sliding plate 74 to slide up and down;

[0123] Two linkage rods 75 are symmetrically arranged between the driven gear 76 and the slide plate 74, the bottom end of the linkage rod 75 is ball-connected with the driven gear 76, and the top end of the linkage rod 75 is ball-connected with the bottom end of the slide plate 74;

[0124] An adjusting assembly, disposed on the outer side wall of the housing 71, for driving the driven gear 76 to rotate;

[0125] The adjustment components include:

[0126] The fixed lock sleeve 7a is fixedly mounted on the outer wall of the cover shell 71, and has a regular octagonal cross section. A fourth tension spring 7c is disposed inside the fixed lock sleeve 7a;

[0127] An adjusting rod 7b, the top of which is fixedly connected to the fourth tension spring 7c, the middle of which is arranged as a regular octagonal column, the middle of which is slidably arranged in the fixed lock sleeve 7a, the upper and lower ends of which are arranged as cylinders, and a turning handle is arranged at the bottom of the adjusting rod 7b;

[0128] The driving gear 7d is rotatably mounted on the housing 71 and meshes with the driven gear 76. A sleeve 7e is fixedly mounted on the bottom end of the driving gear 7d. The cross section of the sleeve 7e is a regular octagon.

[0129] The working process and principle of the waste discharge mechanism 7 are as follows: In order to prevent leakage of gas and liquid discharged from the kettle output pipe 21, it is necessary to seal the connection between the waste discharge mechanism 7 and the kettle output pipe 21. Before connecting with the kettle output pipe 21, the two sets of linkage rods 75 are in an inclined state, the slide plate 74 is at a low point, the space of the independent air chamber is increased, the gas content remains unchanged, and the air pressure is reduced, so the air bag 73 is in a relaxed state. After connecting with the kettle output pipe 21, the kettle output pipe 21 is inserted into the connecting pipe 72, and the air bag 73 is connected to the kettle output pipe. 21 outer wall is fitted but not sealed, at this time, the driven gear 76 is driven to rotate by the adjusting component, and the driven gear 76 drives the two sets of linkage rods 75 to gradually swing to a vertical state, and the vertical height of the linkage rod 75 increases, so the slide plate 74 will slide upward, the space of the independent air chamber is reduced, the gas content remains unchanged, and the air pressure increases, so the airbag 73 is in an expanded state, and the airbag 73 is tightly fitted and sealed with the outer wall of the kettle output pipe 21, completing the docking operation with the kettle output pipe 21, preventing gas and liquid from flowing out during waste discharge, and improving the stability of use.

[0130] Under the pulling force of the fourth tension spring 7c, the adjusting rod 7b moves upward as a whole. At this time, the middle part of the adjusting rod 7b is slidably inserted into the fixed locking sleeve 7a. Since the fixed locking sleeve 7a and the middle part of the adjusting rod 7b are both regular octagonal designs, the self-locking function in the horizontal rotation direction can be realized. At the same time, a part of the middle part of the adjusting rod 7b will still cooperate with the driving gear 7d, so that the driving gear 7d can be locked to prevent the driving gear 7d from rotating. Since the driving gear 7d is meshed with the driven gear 76, the driven gear 76 will not rotate either, and the fixed driven gear 76 can The airbag 73 can be locked. When the airbag 73 needs to be released, the adjusting rod 7b is pulled downward to pull the middle part of the adjusting rod 7b out of the fixed locking sleeve 7a and disengage from the fixed locking sleeve 7a. Then, the adjusting rod 7b cooperates with the driving gear 7d and the sleeve 7e, and the adjusting rod 7b is screwed to drive the driving gear 7d and the sleeve 7e to rotate. Then, the rotating driving gear 7d drives the driven gear 76 to rotate, and the driven gear 76 drives the slide plate 74 to adjust downward, thereby releasing the airbag 73. By setting the adjustment component, the airbag 73 can be adjusted and locked.

[0131] The fully automatic cleaning and disinfection method of the pharmaceutical production equipment of the present invention comprises:

[0132] Place the reactor to be cleaned and disinfected in the cleaning and disinfection device;

[0133] Start the cleaning and disinfection device, introduce high-pressure gas to purge the residues and impurities inside the reactor, introduce cleaning liquid to cover every corner inside the reactor, let the cleaning liquid stay inside the equipment, and dissolve and soften the stubborn stains and residues;

[0134] The cleaning liquid and dissolved waste are discharged, and high-pressure gas is introduced to purge the interior of the reactor to remove water droplets and impurities;

[0135] Close the liquid and air inlets, and use ultraviolet rays to irradiate the interior of the reactor in all directions to kill bacteria and viruses inside the reactor.

[0136] The method combines multiple means such as high-pressure gas purging, cleaning liquid immersion and ultraviolet disinfection, which can effectively remove residues, impurities and stubborn stains inside the reactor, ensure the thoroughness of cleaning and disinfection, and improve the cleanliness and sterility of the equipment; the entire cleaning and disinfection process is completed by a fully automatic cleaning and disinfection device without manual intervention, which greatly improves production efficiency; because the entire cleaning and disinfection process is completed by mechanical automation, the potential safety hazards caused by manual operation are avoided; in addition, the ultraviolet disinfection device can irradiate the interior of the reactor in all directions, kill bacteria and viruses, ensure the sterility of the equipment, and thus improve the safety and reliability of drug production;

[0137] This method reduces the waste of resources by precisely controlling the amount of cleaning liquid and the purging time of high-pressure gas; at the same time, ultraviolet disinfection does not require the use of chemical disinfectants, avoiding the generation of chemical waste liquid; cleanliness and sterility are key factors in the drug production process; using this method to clean and disinfect the reactor can ensure the cleanliness and sterility of the equipment, thereby reducing the risk of contamination in the drug production process and improving product quality and safety.

[0138] The fully automatic cleaning and disinfection device and method for pharmaceutical production equipment of the present invention, when working, places the reaction kettle 2 to be cleaned and disinfected in the cleaning and disinfection device, and ensures that the kettle output pipe 21 is correctly connected to the interface of the waste discharge mechanism 7;

[0139] The lifting mechanism 3 is started to lower the lifting beam 35 to the inside of the reactor 2; at the same time, the lifting mechanism also drives the cleaning mechanism 5 and the disinfection mechanism 4 to move up and down, thereby achieving a comprehensive disinfection task inside the reactor 2;

[0140] The cleaning mechanism 5 is started, and high-pressure gas is delivered to the jet pipe 5a through the air inlet hose 5c, and the residues and impurities inside the reactor are purged through the jet port to ensure preliminary cleaning;

[0141] Start the rotating assembly 6, the motor 61 drives the driving gear 62 to rotate, and then drives the gear ring 63 and the jet pipe 5a to rotate, so that the cleaning mechanism 5 covers the interior of the reactor in all directions;

[0142] The cleaning liquid is delivered to the liquid spraying pipe 5b through the liquid inlet hose 51 and sprayed out through the liquid spraying port to cover every corner inside the reactor. The cleaning liquid is allowed to stay inside the equipment for a period of time to dissolve and soften stubborn stains and residues.

[0143] The second tension spring 53 and the third tension spring 56 ensure the normal operation of the liquid spraying inner tube 55 and the tube plug 57, so that the liquid can be sprayed into the chamber of the reactor 2 in a reciprocating manner.

[0144] After cleaning is completed, the waste discharge mechanism 7 is started, and the slide plate 74 is controlled to slide up and down through the driven gear 76 and the linkage rod 75, so that the waste liquid and waste gas are discharged through the connecting pipe 72;

[0145] Close the liquid inlet, and continue to deliver high-pressure gas to the jet pipe 5a through the air inlet hose 5c to perform a second purge inside the reactor to remove water droplets and residual impurities to ensure that the inside of the reactor is dry;

[0146] Close the liquid and air inlet, start the disinfection mechanism 4, and send the ultraviolet lamp 46 into the reactor through the hanging pipe 41 and the pressing frame 42;

[0147] The guide groove 43 and the guide slider 44 ensure that the ultraviolet lamp assembly can move flexibly inside the reactor, covering all areas that need to be disinfected, including the arc-shaped area at the bottom of the reactor, for comprehensive disinfection;

[0148] After the disinfection is completed, the lifting mechanism 3 is started to raise the lifting beam 35, and the cleaning mechanism 5 and the disinfection mechanism 4 are removed from the reactor;

[0149] Check the cleanliness and disinfection effect inside the reactor and put it back into use after ensuring that it meets the standards.

[0150] The installation method, connection method or setting method of the fully automatic cleaning and disinfection device for pharmaceutical production equipment of the present invention are all common mechanical methods, and can be implemented as long as they can achieve their beneficial effects.

[0151] The above are only preferred embodiments of the present invention. It should be pointed out that, for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the technical principles of the present invention. These improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A fully automatic cleaning and disinfection device for pharmaceutical production equipment, characterized in that: include: Main frame, independently fixed; A reaction kettle, wherein a chamber is arranged inside, and a kettle output pipe is arranged at the bottom of the reaction kettle; A lifting mechanism, comprising a lifting beam that slides vertically on the main support; A cleaning mechanism is rotatably mounted on the lifting beam and is used to transport cleaning water and cleaning gas; A disinfection mechanism, arranged on the cleaning mechanism, for disinfecting the reaction kettle; A rotating assembly, arranged on the lifting beam, for driving the cleaning mechanism to rotate; The waste discharge mechanism is fixedly mounted on the main support and is connected to the kettle output pipe to receive waste liquid and waste gas; Wherein, the disinfection mechanism also includes: A hanging pipe is slidably arranged on the cleaning mechanism; A downward pressing frame is fixedly mounted on the hanging pipe; Two guide slides are symmetrically mounted on the cleaning mechanism, a plurality of ultraviolet lamp assemblies are slidably arranged in the guide slides, the ultraviolet lamp assemblies include guide sliders slidably mounted in the guide slides, upper and lower end surfaces of the guide sliders are both arranged as inclined surfaces; a connecting plate is also included, which is fixedly connected to the guide sliders; and an ultraviolet lamp is also included, which is fixedly connected to the connecting plate; A plurality of top springs, fixedly connected to the connecting plates, and used to connect adjacent connecting plates; Adjacent guide slide blocks are hinged to each other.

2. The fully automatic cleaning and disinfecting device for pharmaceutical production equipment according to claim 1, characterized in that: The lifting mechanism is provided with two, which are respectively arranged at the two ends of the lifting beam, and the lifting mechanism comprises: A cylinder, fixedly mounted on the main support; The telescopic rod is driven by the cylinder to move up and down; A transmission arm, the top end of which is hinged to the telescopic rod; A lifting slider is slidably mounted in the main frame and fixedly connected to the lifting beam; A linkage slider slides on the bottom surface of the lifting beam; the bottom end of the transmission arm is hinged to the linkage slider; A first tension spring, arranged between the linkage slider and the lifting slider; A bearing ring, sleeved on the cleaning mechanism; The linkage plate has two ends hinged to the linkage slider and the bearing ring respectively.

3. The fully automatic cleaning and disinfecting device for pharmaceutical production equipment according to claim 1, characterized in that: Two lampshade plates are symmetrically and fixedly mounted on each of the ultraviolet lamps, and an optical film is arranged on the inner end surface of the lampshade plate.

4. The fully automatic cleaning and disinfecting device for pharmaceutical production equipment according to claim 3, characterized in that: The lampshade plate is configured as a "Z" shaped plate.

5. The fully automatic cleaning and disinfecting device for pharmaceutical production equipment according to claim 1, characterized in that: The cleaning mechanism comprises: The jet pipe is rotatably mounted on the lifting beam, and a jet port is provided at the bottom thereof, and the jet port is configured to be wide-mouthed; A liquid spray pipe is fixedly inserted in the air jet pipe, a liquid spray port is arranged at the bottom end, the liquid spray port is arranged in a wide-mouth shape, and a ventilation cavity is arranged between the liquid spray pipe and the air jet pipe; An air intake hose is connected to the air injection pipe and is used for conveying high-pressure gas.

6. The fully automatic cleaning and disinfecting device for pharmaceutical production equipment according to claim 5, characterized in that: The cleaning mechanism also includes: A liquid inlet hose, connected to the liquid spray pipe, for conveying cleaning liquid; A first cross beam piece is fixedly mounted inside the liquid spraying pipe, and a second tension spring is hooked and mounted on the bottom end; The liquid spraying inner tube is slidably arranged at the bottom end of the liquid spraying tube, a second cross beam is fixedly installed inside the tube, the bottom end of the second tension spring is fixedly connected to the second cross beam, the second tension spring is used to pull the liquid spraying inner tube, and a third tension spring is hooked and installed at the bottom end of the second cross beam; The pipe plug is slidably arranged at the bottom end of the liquid spraying inner tube, the top end of the pipe plug is arranged in a cone shape, the top end of the pipe plug is fixedly connected to the bottom end of the third tension spring, and the third tension spring is used to pull the pipe plug so that the pipe plug is inserted into the liquid spraying inner tube.

7. The fully automatic cleaning and disinfecting device for pharmaceutical production equipment according to claim 6, characterized in that: The rotating assembly comprises: A motor, fixedly mounted on the lifting beam, with a driving gear fixedly mounted on an output end thereof; A gear ring, fixedly sleeved on the outer wall of the jet pipe and meshing with the driving gear; A turntable is rotatably mounted on the top of the main support, and the tops of the air inlet hose and the liquid inlet hose are fixedly mounted on the turntable.

8. The fully automatic cleaning and disinfecting device for pharmaceutical production equipment according to claim 1, characterized in that: The waste discharge mechanism comprises: A cover shell is slidably arranged on the main body bracket, a top end of which is provided with an interface and communicated with the kettle output pipe, and a waste discharge pipe is arranged at the bottom end of the cover shell; The connecting pipe is fixedly installed inside the housing, and a plurality of vents are arranged on the upper part thereof. An air bag is fixedly mounted on the connecting pipe and covers the vent; A slide plate is slidably mounted between the connecting pipe and the cover shell, and an independent air chamber is located above the slide plate.

9. The fully automatic cleaning and disinfecting device for pharmaceutical production equipment according to claim 8, characterized in that: The waste discharge mechanism also includes: A driven gear, rotatably mounted at the bottom end of the housing, for controlling the sliding plate to slide up and down; Two linkage rods are symmetrically arranged between the driven gear and the slide plate, the bottom end of the linkage rod is ball-connected with the driven gear, and the top end of the linkage rod is ball-connected with the bottom end of the slide plate; An adjusting assembly is arranged on the outer side wall of the housing and is used for driving the driven gear to rotate.

10. A fully automatic cleaning and disinfection method for pharmaceutical production equipment, characterized in that: A fully automatic cleaning and disinfecting device for pharmaceutical production equipment as claimed in any one of claims 1 to 9, comprising the steps of: Place the reactor to be cleaned and disinfected in the cleaning and disinfection device; Start the cleaning and disinfection device, introduce high-pressure gas to purge the residues and impurities inside the reactor, introduce cleaning liquid to cover every corner inside the reactor, let the cleaning liquid stay inside the equipment, and dissolve and soften the stubborn stains and residues; The cleaning liquid and dissolved waste are discharged, and high-pressure gas is introduced to purge the interior of the reactor to remove water droplets and impurities; Close the liquid and air inlets, and use ultraviolet rays to irradiate the interior of the reactor in all directions to kill bacteria and viruses inside the reactor.

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