A method, apparatus, system, and medium for leak compensation of high frequency ventilation

Abstract

The application discloses a high-frequency ventilation leak compensation method, device, system and medium, and the method comprises the following steps: acquiring the real-time flow rate and real-time pressure of a breathing machine; integrating the real-time flow rate with a first time period, and integrating the real-time pressure with the first time period by calling a preset pressure formula with positive and negative signs after confirming the direction of the real-time pressure; when reaching a second time period, calculating a leakage factor according to the integral result of the current real-time flow rate and the integral result of the real-time pressure, and clearing the integral result; calculating a leakage flow rate according to the leakage factor by calling a leakage flow rate formula with positive and negative signs, and compensating the leakage of the breathing machine according to the leakage flow rate. By confirming the direction of the real-time pressure, integrating with the formula with signs, and calculating the leakage factor, the leakage can still be accurately compensated when a large amount of negative pressure is generated due to high-frequency oscillation in high-frequency ventilation, and the reliability of high-frequency ventilation is improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical equipment, in particular to a leak compensation method, device, system and medium for high frequency ventilation. BACKGROUND

[0002] In neonatal mechanical ventilation, the lungs of the newborn are not yet developed, and the compliance of the lungs is much smaller than that of adults. In order to achieve a certain tidal volume, a higher pressure is needed, but the lungs of the newborn are very fragile, and too high a pressure will cause harm to the patient's lungs. Therefore, in order to ensure the minute ventilation of the newborn, the frequency is increased to try to reduce the ventilation pressure, and the lung expiration time constant of the newborn is very small, which can ensure that the expiration time is very short. High frequency ventilation HFO (High Frequency Oscillation) has become a mechanical ventilation option suitable for newborns.

[0003] Leakage is a very common phenomenon in mechanical ventilation. Common leakage positions, leakage ports on the pipeline, etc. will cause leakage in the pipeline. In order to correctly estimate the flow into the patient's lungs, to correctly trigger the flow rate and calculate the tidal volume, almost all ventilators have automatic leak compensation function.

[0004] In the traditional leak compensation calculation, the airway pressure is not allowed to be negative. For conventional ventilation, the negative interval of spontaneous breathing is usually small and can be ignored, so the accuracy of leak compensation is less affected. However, in high frequency ventilation, since high frequency ventilation is generated by the high frequency vibration of the vibrator, the exhalation is the forced exhalation of the ventilator rather than the active exhalation of the patient. Therefore, when the mean pressure is low, the vibrator can frequently generate negative pressure, that is, the ventilator can actively draw negative pressure in a large number of periodic cycles. Therefore, if the traditional leak compensation method is used in high frequency ventilation, the accuracy of leak compensation will be insufficient. SUMMARY

[0005] In view of the shortcomings of the prior art, the purpose of the present application is to provide a leak compensation method, device, system and medium for high frequency ventilation, which aims to improve the accuracy of leak compensation under high frequency ventilation.

[0006] The technical solution of the present application is as follows:

[0007] A leak compensation method for high frequency ventilation, comprising:

[0008] obtaining the real-time flow rate and real-time pressure of the ventilator;

[0009] integrating the real-time flow rate with a first time period, and after confirming the direction of the real-time pressure, calling a preset pressure formula with positive and negative signs to integrate the real-time pressure with the first time period;

[0010] when the second time period is reached, a leak factor is calculated according to the integral result of the real-time flow rate and the integral result of the real-time pressure, and the integral results are cleared;

[0011] a leak flow rate is calculated according to the leak factor and a leak flow rate formula with positive and negative signs, and the ventilator is compensated for leakage according to the leak flow rate.

[0012] In one embodiment, the second time period is much larger than the first time period.

[0013] In one embodiment, after the real-time flow rate is integrated for the first time period and the direction of the real-time pressure is determined, the real-time pressure is integrated for the first time period according to a preset pressure formula with positive and negative signs, including:

[0014] by the formula the real-time flow rate is integrated for the first time period, where Flow is the real-time flow rate and t is time;

[0015] the real-time pressure is determined to be positive or negative pressure, obtaining the positive and negative signs of the real-time pressure;

[0016] by a preset pressure formula with positive and negative signs the real-time pressure is integrated for the first time period, where sign(P aw (t)) is the positive and negative sign of the real-time pressure, |P aw (t)| is the absolute value of the pressure, t is time, and T is a time containing an integer multiple of a complete high frequency period.

[0017] In one embodiment, when the second time period is reached, a leak factor is calculated according to the integral result of the real-time flow rate and the integral result of the real-time pressure, and the integral results are cleared, specifically:

[0018] when the second time period is reached, a leak factor is calculated according to the integral result of the real-time flow rate and the integral result of the real-time pressure, and the integral results are cleared; where LeakFactor is the leak factor.

[0019] In one embodiment, a leak flow rate is calculated according to the leak factor and a leak flow rate formula with positive and negative signs, and the ventilator is compensated for leakage according to the leak flow rate, including:

[0020] based on the leak factor, a leak flow rate is calculated by a leak flow rate formula with positive and negative signs where Flow leakLeakFactor is a leak factor, sign(P aw (t)) is a positive or negative sign of the real-time pressure, |P aw (t)| is an absolute value of the pressure, and t is time.

[0021] Leakage compensation is performed on the real-time flow rate of the ventilator according to the leak flow rate.

[0022] In one embodiment, the method further comprises:

[0023] It is determined whether the ventilator is in a high-frequency ventilation mode in which high-frequency oscillator oscillation ventilation is generated.

[0024] In one embodiment, the first time period is 1 ms, and the second time period is 3 s.

[0025] A leakage compensation device for high-frequency ventilation, characterized in that it comprises:

[0026] An acquisition module is configured to acquire a real-time flow rate and a real-time pressure of a ventilator.

[0027] An integration module is configured to integrate the real-time flow rate for a first time period and, after determining the direction of the real-time pressure, call a preset pressure formula with a positive or negative sign to integrate the real-time pressure for the first time period.

[0028] A calculation module is configured to, when a second time period is reached, calculate a leak factor according to an integration result of the current real-time flow rate and an integration result of the real-time pressure, and clear the integration results.

[0029] A leakage compensation module is configured to call a leak flow rate formula with a positive or negative sign to calculate a leak flow rate according to the leak factor, and perform leakage compensation on the ventilator according to the leak flow rate.

[0030] A leakage compensation system for high-frequency ventilation, the system comprising at least one processor; and

[0031] A memory in communication connection with the at least one processor; wherein

[0032] The memory stores instructions executable by the at least one processor, and the instructions are executed by the at least one processor to enable the at least one processor to perform the above-mentioned leakage compensation method for high-frequency ventilation.

[0033] A non-volatile computer-readable storage medium stores computer-executable instructions, and the computer-executable instructions, when executed by one or more processors, can cause the one or more processors to perform the above-mentioned leakage compensation method for high-frequency ventilation.

[0034] Beneficial effects: The application discloses a leak compensation method, device, system and medium for high-frequency ventilation, compared with the prior art, the application embodiment confirms the real-time pressure direction and performs integration and leak factor calculation by using a formula with a symbol, so that the leak can be accurately compensated when a large amount of negative pressure is generated due to high-frequency oscillation in high-frequency ventilation, and the reliability of high-frequency ventilation is improved. BRIEF DESCRIPTION OF DRAWINGS

[0035] The application will be further described below with reference to the drawings and embodiments. In the drawings:

[0036] Figure 1 A flowchart of the leak compensation method for high-frequency ventilation provided by the application embodiment;

[0037] Figure 2 A functional module schematic diagram of the leak compensation device for high-frequency ventilation provided by the application embodiment;

[0038] Figure 3 A hardware structure schematic diagram of the leak compensation system for high-frequency ventilation provided by the application embodiment. DETAILED DESCRIPTION

[0039] To make the objectives, technical solutions and effects of the application clearer and more explicit, the application will be further described in detail below. It should be understood that the specific embodiments described herein are only used to explain the application and do not limit the application. The application embodiments will be introduced below with reference to the drawings.

[0040] Please refer to Figure 1 , Figure 1 A flowchart of one embodiment of the leak compensation method for high-frequency ventilation provided by the application. As shown in Figure 1 , the method specifically includes the following steps:

[0041] S100, acquiring real-time flow rate and real-time pressure of a ventilator;

[0042] S200, integrating the real-time flow rate at a first time period, and integrating the real-time pressure at the first time period after confirming the direction of the real-time pressure by calling a preset pressure formula with positive and negative signs;

[0043] S300, when the second time period is reached, calculating a leak factor according to the integration result of the current real-time flow rate and the integration result of the real-time pressure, and clearing the integration result;

[0044] S400, calculating a leak flow rate according to the leak factor by calling a leak flow rate formula with positive and negative signs, and compensating the leak of the ventilator according to the leak flow rate.

[0045] In this embodiment, the leakage compensation function generally assumes that the leakage port has a fixed aperture, and the leakage flow rate is related to the pressure difference inside and outside the leakage port and the leakage factor. In leakage compensation, the leakage factor needs to be accurately estimated to accurately compensate the leakage flow rate. In high-frequency invasive ventilation, in order to meet the needs of rapid oscillation of pressure and flow rate, the calculation of the leakage factor needs to be performed at a high enough sampling frequency. Therefore, after obtaining the real-time flow rate and real-time pressure of the ventilator, the real-time flow rate and real-time pressure are integrated for a very short first time period, so as to ensure the accuracy of high-frequency integration. In particular, when integrating the real-time pressure, it is necessary to confirm the direction of the real-time pressure, i.e., whether the current pipeline is under positive pressure or negative pressure. After confirmation, a preset pressure formula with positive and negative signs is called to integrate the real-time pressure for the first time period.

[0046] After that, in order to ensure the stability of the parameters, the leakage factor is not settled every period, but a longer time is selected, i.e., when a longer second time period is reached, the leakage factor is calculated according to the integral results of the real-time flow rate and the real-time pressure, and the integral results are cleared to enter the parameter calculation of the next period. That is, on the basis of high-frequency sampling, the leakage factor is calculated and updated once every longer second time period, so as to obtain a more stable leakage factor and avoid the influence of high-frequency leakage factor update on the stability of the parameters.

[0047] Based on the leakage factor calculated in the current period, a leakage flow rate formula with positive and negative signs is called to calculate the leakage flow rate, so as to compensate the ventilator according to the leakage flow rate. In addition, the tidal volume, minute ventilation, gas transport coefficient of carbon dioxide (DCO2) and other patient-related parameters can be further calculated through the flow rate after leakage compensation, so as to solve the problem that the existing leakage model cannot compensate for negative pressure leakage, improve the accuracy of leakage compensation in this working condition, and thus improve the accuracy of high-frequency tidal volume, minute ventilation and other parameters in the leakage condition.

[0048] In one embodiment, the second time period is much longer than the first time period. In order to meet the needs of rapid oscillation of pressure and flow rate, the calculation of the leakage factor needs to be performed at a sufficiently high sampling frequency. At the same time, in order to ensure the stability of the parameters, the leakage factor will not be calculated immediately after each integral sampling, but will be settled once in a longer time period. Therefore, the second time period is much longer than the first time period, wherein the second time period is on the order of seconds, and the first time period is on the order of milliseconds. For example, the first time period is 1ms, and the second time period is 3s. That is to say, based on the acquired real-time flow rate and real-time pressure, the flow rate and pressure are integrated respectively with a period of 1ms to ensure the accuracy of high-frequency integration. When it reaches 3s, the leakage factor of the current period is calculated based on the integral result of the complete 3s and the integral is cleared. The second time period is on the order of seconds, for example, set to 3s, considering that the frequency of the high frequency is set in Hz. If an integer second is selected, it must always be an integer multiple of a complete breath. A fixed 3s can use data of sufficient length to increase stability, thereby obtaining a more stable leakage factor.

[0049] In one embodiment, step S200 includes:

[0050] By formula Integrating the real-time flow rate over a first time period, where Flow is the real-time flow rate and t is time;

[0051] confirming whether the real-time pressure is positive or negative, and obtaining the positive or negative sign of the real-time pressure;

[0052] By pre-set pressure formula with positive and negative signs The real-time pressure is integrated over a first time period, where sign(P aw (t)) is the positive and negative sign of the real-time pressure, |P aw (t)| is the absolute value of the pressure, t is time, and T is the time containing an integer multiple of a complete high-frequency cycle.

[0053] In this embodiment, the formula The real-time flow rate is integrated for the first time period (1ms in this embodiment), and the real-time pressure in the pipeline is also confirmed to be positive or negative. When the pressure in the pipeline is greater than the atmospheric pressure of the environment outside the pipeline, it is positive pressure, and when the pressure in the pipeline is less than the atmospheric pressure of the environment outside the pipeline, it is negative pressure. aw (t)) as the positive and negative signs of the real-time pressure participate in the pressure integration, through the formula The real-time pressure is integrated for a first time period (1 ms in this embodiment) to accurately sample the flow rate and pressure even when a large negative pressure is generated in high frequency ventilation. The integration time Δt is a first time period of the order of milliseconds, thereby satisfying the need for rapid oscillation of pressure and flow rate and improving sampling accuracy.

[0054] In one embodiment, when the second time period is reached, a leak factor is calculated based on the integration result of the current real-time flow rate and the integration result of the real-time pressure, and the integration results are cleared, specifically:

[0055] When the second time period is reached, a leak factor is calculated by the formula and the integration results of the current integration period are cleared, where LeakFactor is the leak factor.

[0056] In this embodiment, the relationship between the pressure difference of the fixed orifice leak and the flow rate is approximately a square root relationship:

[0057]

[0058] where Flow leak is the leak flow rate through the fixed orifice leak, A is the area of the leak, C d is the flow coefficient, which can be considered constant, ρ is the gas density, which can be considered constant, and ΔP is the pressure difference inside and outside the leak. Considering the direction of flow rate and pressure difference, the formula should be:

[0059]

[0060] where sign is the sign of the value, and the formula for the fixed orifice leak factor is obtained, assuming that atmospheric pressure is 0 and the pressure in the pipeline is P aw (t), i.e. ΔP = P aw (t), which gives:

[0061]

[0062] where LeakFactor is the leak factor combined from various coefficients, which is constant when the orifice diameter of the leak is fixed. When estimating the leak factor, it is generally assumed that the tidal volume of a patient inhaling for one or more breaths is equal to the tidal volume of a patient exhaling, i.e.

[0063]

[0064] where T represents an integer multiple of the complete respiratory cycle time, which can be fixed at 3 s, i.e. the second time period in this embodiment, and Flow pat is the patient flow rate, which is the real-time flow rate Flow monitored by the ventilator minus the leak flow rate:

[0065] Flow pat (t) = Flow(t) - Flow leak (t)

[0066] By the above formula, the leakage factor is Therefore, after the millisecond-level integration of the flow rate and the pressure respectively, when reaching a longer second time period, the formula is called to calculate the leakage factor, so that the leakage factor can be accurately updated in each calculation period in high-frequency ventilation, whether it is positive pressure or negative pressure, thereby improving the accuracy of leakage compensation in high-frequency ventilation, and further improving the accuracy of high-frequency tidal volume and minute ventilation in the leakage condition.

[0067] In one embodiment, step S400 comprises:

[0068] Based on the leakage factor, the leakage flow rate formula with positive and negative signs is used to calculate the leakage flow rate, wherein Flow leak is the leakage flow rate, LeakFactor is the leakage factor, sign(P aw (t)) is the positive and negative sign of the real-time pressure, |P aw (t)| is the absolute value of the pressure, and t is time.

[0069] The real-time flow rate of the ventilator is compensated for leakage based on the leakage flow rate.

[0070] In this embodiment, after the flow rate and the pressure are accurately integrated and the leakage factor is calculated based on the formula with positive and negative signs, the leakage flow rate formula with positive and negative signs is used to update the leakage flow rate under the new leakage factor, thereby adjusting the real-time flow rate of the current ventilator and compensating for the flow rate of the ventilator for leakage, effectively solving the problem that a large amount of negative pressure can be generated in high-frequency oscillation, and the negative pressure needs to be compensated for leakage, so that the flow rate of the ventilator can still be accurately compensated for leakage in high-frequency ventilation.

[0071] In one embodiment, the method further comprises:

[0072] Confirming whether the ventilator is in a high-frequency ventilation mode in which high-frequency oscillation is generated by the oscillator.

[0073] In this embodiment, based on different application scenarios of the ventilator, in the high-frequency ventilation mode, only the high-frequency vibrator oscillation can generate stable negative pressure, and machine-controlled inspiration, machine-controlled inspiration and machine-controlled expiration are performed by using the special high-frequency vibrator oscillation. It can be confirmed whether the ventilator is in the high-frequency ventilation mode of the high-frequency vibrator oscillation to generate ventilation. If it is high-frequency ventilation, the ventilator is precisely compensated for leakage through the steps in the above embodiment. If it is not high-frequency ventilation, the leakage compensation can be performed through the existing compensation mode of the ventilator, so as to adapt to the leakage compensation demand in different application scenarios.

[0074] Another embodiment of the present application provides a leakage compensation device for high-frequency ventilation, as shown in Figure 2 The device 1 comprises:

[0075] The acquisition module 11 is configured to acquire the real-time flow rate and the real-time pressure of the ventilator.

[0076] The integration module 12 is configured to integrate the real-time flow rate in a first time period, and integrate the real-time pressure in the first time period after confirming the direction of the real-time pressure by calling a preset pressure formula with positive and negative signs.

[0077] The calculation module 13 is configured to calculate a leakage factor according to the integration result of the current real-time flow rate and the integration result of the real-time pressure when the second time period is reached, and clear the integration result.

[0078] The leakage compensation module 14 is configured to calculate a leakage flow rate according to the leakage factor by calling a leakage flow rate formula with positive and negative signs, and compensate for the leakage of the ventilator according to the leakage flow rate.

[0079] The modules and units referred to in the present application refer to a series of computer program instruction segments capable of completing a specific function. The program is more suitable for describing the execution process of the leakage compensation of high-frequency ventilation. The specific implementation of each module is described in the above corresponding method embodiment, which will not be described here.

[0080] Another embodiment of the present application provides a leakage compensation system for high-frequency ventilation, as shown in Figure 3 The system 10 comprises:

[0081] One or more processors 110 and memories 120, Figure 3 In this embodiment, the processor 110 and the memory 120 can be connected through a bus or other means. Figure 3 In this embodiment, the connection through the bus is taken as an example.

[0082] The processor 110 is configured to implement various control logic of the system 10, and can be a general-purpose processor, a digital signal processor (DSP), an application-specific integrated circuit (ASIC), a field programmable gate array (FPGA), a single-chip computer, an ARM (Acorn RISC Machine), or other programmable logic device, discrete gate or transistor logic, discrete hardware components, or any combination thereof. In addition, the processor 110 can also be any conventional processor, microprocessor, or state machine. The processor 110 can also be implemented as a combination of computing devices, such as a combination of a DSP and a microprocessor, a plurality of microprocessors, one or more microprocessors in conjunction with a DSP core, and / or any other such configuration.

[0083] The memory 120 is a non-volatile computer-readable storage medium configured to store non-volatile software programs, non-volatile computer-executable programs, and modules, such as program instructions corresponding to the leak compensation method for high frequency ventilation in the embodiments of the present application. The processor 110 executes various functional applications and data processing of the system 10 by running the non-volatile software programs, instructions, and units stored in the memory 120, i.e., implements the leak compensation method for high frequency ventilation in the above-described method embodiments.

[0084] The memory 120 can include a program storage area and a data storage area, wherein the program storage area can store an operating system and application programs required by at least one function; and the data storage area can store data created according to the use of the system 10, etc. In addition, the memory 120 can include a high-speed random access memory, and can also include a non-volatile memory, such as at least one magnetic disk storage device, a flash memory device, or other non-volatile solid-state memory device. In some embodiments, the memory 120 can optionally include a memory remotely disposed relative to the processor 110, and these remote memories can be connected to the system 10 through a network. Examples of the above-mentioned network include but are not limited to the Internet, an intranet, a local area network, a mobile communication network, and a combination thereof.

[0085] One or more units are stored in the memory 120 and, when executed by the one or more processors 110, perform the leak compensation method for high frequency ventilation in any of the above-described method embodiments, such as performing the method steps S100 to S400 in the above-described Figure 1

[0086] The embodiments of the present application provide a non-volatile computer-readable storage medium, which stores computer-executable instructions, and the computer-executable instructions are executed by one or more processors, such as performing the method steps S100 to S400 in the above-described Figure 1

[0087] ​​By way of example, nonvolatile storage can include read-only memory (ROM), programmable ROM (PROM), electrically programmable ROM (EPROM), electrically erasable ROM (EEPROM), or flash memory. Volatile storage can include random-access memory (RAM), which acts as external cache memory. By way of example, and not limitation, RAM can be provided in numerous forms such as synchronous RAM (SRAM), dynamic RAM (DRAM), synchronous DRAM (SDRAM), double-data rate SDRAM (DDR SDRAM), enhanced SDRAM (ESDRAM), Synchlink DRAM (SLDRAM), and direct Rambus DRAM (DRDRAM). Combinations of the above should also be considered as being within the scope of storage components or memory, as described herein. The disclosed memory components or memory of the operating environments described herein are intended to include one or any combination of the above as well as other suitable types of memory.

[0088] In summary, in the high frequency ventilation leak compensation method, device, system and medium, the real-time flow rate and the real-time pressure of the ventilator are obtained; the real-time flow rate is integrated with a first time period, and after confirming the direction of the real-time pressure, the real-time pressure is integrated with the first time period by calling a preset pressure formula with positive and negative signs; when the second time period is reached, a leak factor is calculated according to the integration result of the current real-time flow rate and the integration result of the real-time pressure, and the integration results are cleared; the leak flow rate is calculated according to the leak factor by calling a leak flow rate formula with positive and negative signs, and the ventilator is compensated for leakage according to the leak flow rate. By confirming the direction of the real-time pressure and integrating with the formula with signs and calculating the leak factor, accurate compensation for leakage can still be made when a large amount of negative pressure is generated due to high-frequency oscillation in high-frequency ventilation, and the reliability of high-frequency ventilation is improved.

[0089] Of course, those skilled in the art can understand that all or part of the processes in the above-mentioned embodiment methods can be completed by instructing relevant hardware (such as a processor, a controller, etc.) through a computer program, and the computer program can be stored in a non-volatile computer-readable storage medium. When the computer program is executed, it can include the processes of the above-mentioned method embodiments. The storage medium can be a memory, a disk, a floppy disk, a flash memory, an optical storage, etc.

[0090] It should be understood that the application of the present application is not limited to the above examples, and those skilled in the art can make improvements or changes according to the above description, and all these improvements and changes should be within the scope of protection of the appended claims of the present application.

Claims

1. A leak compensation device for high frequency ventilation, characterized in that The application relates to a leakage compensation device for high-frequency ventilation of a breathing machine. The application comprises: an acquisition module for acquiring real-time flow rate and real-time pressure of the breathing machine; an integration module for integrating the real-time flow rate in a first time period and integrating the real-time pressure in the first time period by calling a preset pressure formula with positive and negative signs after confirming the direction of the real-time pressure; a calculation module for calculating a leakage factor according to the integration result of the real-time flow rate and the integration result of the real-time pressure when a second time period is reached, and clearing the integration result; 2. The leak compensation device for high frequency ventilation according to claim 1, characterized in that a leakage compensation module for calculating a leakage flow rate according to the leakage factor by calling a leakage flow rate formula with positive and negative signs, and compensating the leakage of the breathing machine according to the leakage flow rate.

3. The leak compensation device for high frequency ventilation of claim 1, wherein, The second time period is much larger than the first time period. by the equation integrating the real-time flow rate over a first time period, wherein is the real-time flow rate and t is time; The integration of the real-time flow rate in the first time period and the integration of the real-time pressure in the first time period by calling a preset pressure formula with positive and negative signs after confirming the direction of the real-time pressure comprise: By a preset pressure formula with positive and negative signs integrating the real-time pressure over a first time period, wherein is the positive or negative sign of the real-time pressure, is the absolute value of the pressure, and t is time.

4. The leak-compensating device for high-frequency ventilation according to claim 3, characterized in that confirming whether the real-time pressure is positive pressure or negative pressure to obtain the positive and negative signs of the real-time pressure; When the second time period is reached, the leakage factor is calculated by the formula and the integration result of the current integration period is emptied, where is the leakage factor.

5. The leak-compensating device for high-frequency ventilation according to claim 4, characterized in that The calculation of the leakage factor according to the integration result of the real-time flow rate and the integration result of the real-time pressure when a second time period is reached, and the clearing of the integration result, specifically comprise: based on the leakage factor, by a leakage flow rate formula with positive and negative signs calculating a leakage flow rate, wherein is the leakage flow rate, is the leakage factor, is the positive and negative sign of the real-time pressure, is the absolute value of the pressure, and t is time; The calculation of the leakage flow rate according to the leakage factor by calling a leakage flow rate formula with positive and negative signs, and the compensation of the leakage of the breathing machine according to the leakage flow rate, comprise:

6. The leak-compensating device for high frequency ventilation according to claim 1, characterized in that compensating the leakage of the real-time flow rate of the breathing machine according to the leakage flow rate. The application further comprises:

7. The leak-compensating device for high-frequency ventilation according to claim 1, characterized in that confirming whether the breathing machine is in a high-frequency ventilation mode in which high-frequency ventilation is generated by a high-frequency oscillator.

8. A leak compensation system for high frequency ventilation, characterized in that The first time period is 1 ms, and the second time period is 3 s. The application comprises the leakage compensation device for high-frequency ventilation of the breathing machine according to any one of claims 1-7.

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