Ultrasonic enhanced intravascular guide wire with antibacterial function

Abstract

The invention belongs to the technical field of medical equipment, and discloses an ultrasonic enhanced intravascular guide wire with an antibacterial function, which comprises a guide wire base part and a nano silver ion plating layer, a uniform nano-silver ion plating layer is plated on the surface of the guide wire substrate part; the nano-silver ion plating layer is uniformly attached to the surface of the guide wire through an electroplating or chemical plating process, and the thickness is controlled to be 1-2 microns. According to the method, the ultrasonic visibility is enhanced, and the development effect of the guide wire under ultrasound is remarkably enhanced through the nano-silver ions in the coating on the surface of the guide wire. The nano-silver ions have excellent acoustic impedance characteristics and can reflect ultrasonic waves more effectively than traditional materials, so that the contrast ratio and definition of the guide wire in an ultrasonic image are improved. Therefore, operation under ultrasonic guidance is more accurate, and real-time tracking and guide wire control are more convenient. In addition to improvement of ultrasonic visibility, silver ions also have an antibacterial effect, so that growth of bacteria can be effectively inhibited, and infection in a vascular intervention process is prevented.

Description

Technical Field

[0001] The invention belongs to the technical field of medical equipment, and in particular relates to an ultrasonic image-enhanced intravascular guidewire with antibacterial function. Background Art

[0002] Traditional guidewires have poor ultrasound visibility: Traditional intravascular guidewires have low contrast under ultrasound imaging, making them difficult to accurately track and locate during surgical procedures. This not only increases the complexity of the surgery, but may also lead to complications and even require additional imaging technology to assist, wasting time and increasing costs.

[0003] Infection risk of medical devices: During vascular invasive medical procedures, guidewires and other devices are in contact with human blood vessels for a long time, and the risk of infection always exists. Traditional guidewires lack antibacterial protection and cannot effectively prevent bacterial growth and infection, increasing medical risks.

[0004] Through the above analysis, the problems and defects of the prior art are as follows:

[0005] (1) Poor ultrasound visibility of traditional guidewires: Traditional intravascular guidewires have low contrast under ultrasound imaging, making them difficult to accurately track and locate during surgical operations. This not only increases the complexity of the surgery, but may also lead to complications and even require additional imaging technology to assist, wasting time and increasing costs.

[0006] (2) Infection risk of medical devices: During invasive medical procedures, guidewires and other devices are in contact with the human body for a long time, and the risk of infection always exists. Traditional guidewires lack antibacterial protection and cannot effectively prevent bacterial growth and infection, increasing medical risks. Summary of the invention

[0007] In view of the problems existing in the prior art, the present invention provides an ultrasound image-enhanced intravascular guidewire with antibacterial function.

[0008] The present invention is implemented in this way: an ultrasound-enhanced intravascular guidewire with antibacterial function comprises:

[0009] Guidewire base part, nano silver ion plating layer;

[0010] The surface of the base part of the guide wire is plated with a uniform nano silver ion plating layer; the nano silver ion plating layer is uniformly attached to the surface of the guide wire through an electroplating or chemical plating process, and the thickness is controlled between 1-2 microns.

[0011] Further, the guidewire base portion:

[0012] The base part of the guide wire is made of high-strength alloy or stainless steel material; the base part is designed to be slender and flexible.

[0013] Furthermore, the guidewire base portion is generally circular or an elongated linear structure, and the design meets the requirements of vascular interventional surgery.

[0014] Furthermore, both ends of the guidewire base portion may be designed to be tapered or pointed.

[0015] Furthermore, the guidewire base portion can be connected to ultrasound equipment and other image-guided equipment, and connected to a monitoring system via a cable or wireless data transmission to ensure real-time display of the positioning of the guidewire in the body.

[0016] Furthermore, the surface of the guidewire base portion may also be embedded with sensors including pressure sensors or temperature sensors.

[0017] In combination with the above technical solutions and the technical problems solved, the advantages and positive effects of the technical solutions to be protected by the present invention are as follows:

[0018] Ordinary guide wires are coated with a layer of nano-silver ions. Nano-silver ions are used to coat the ordinary intravascular guide wires to enhance ultrasound imaging. Nano-silver ions also have antibacterial effects.

[0019] The present invention relates to an ultrasound-enhanced intravascular guidewire for medical applications, especially for vascular interventional surgery. The guidewire is coated with nano-silver ions and has the following two main functions:

[0020] 1. Enhanced ultrasound visibility: The nano silver ions in the surface coating of the guide wire significantly enhance the visualization effect of the guide wire under ultrasound. Nano silver ions have excellent acoustic impedance characteristics and can reflect ultrasound more effectively than traditional materials, thereby improving the contrast and clarity of the guide wire in ultrasound images. This can make the operation under ultrasound guidance more accurate and the real-time tracking and manipulation of the guide wire more convenient.

[0021] 2. Antibacterial function: In addition to improving ultrasound visibility, silver ions also have antibacterial effects, which can effectively inhibit the growth of bacteria and prevent infection during vascular intervention. The antibacterial properties of silver have been widely studied and can reduce the formation of bacterial biofilms, thereby reducing the risk of infection and providing additional safety.

[0022] 3. Significant improvement in ultrasound visibility: By coating the guidewire with silver nanoparticles, the contrast in ultrasound images is significantly enhanced, making the guidewire more visible under ultrasound. This improves the accuracy of vascular interventional surgery and reduces the risk of operation.

[0023] 4. Antibacterial effect: Nano silver ions provide the guide wire with a long-lasting antibacterial function, which can effectively reduce the risk of infection, especially in the case of long-term use or repeated insertion and removal. Silver ions help inhibit the growth of bacteria and reduce the formation of bacterial biofilm, thereby greatly reducing the chance of infection during surgery.

[0024] 5. Save costs and improve efficiency: By combining ultrasound enhancement and antibacterial functions, the present invention provides a solution that can both improve surgical precision and reduce the risk of infection. This not only reduces the reliance on other imaging techniques or antibacterial treatments, but also effectively reduces medical expenses and improves surgical outcomes for patients.

[0025] This invention innovatively solves the problems of poor visualization and insufficient antibacterial performance of the guide wire under ultrasound guidance by adding silver nanoparticles to the surface coating of the guide wire, thereby improving the safety and efficiency of the medical device. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 This is a structural diagram of an ultrasound-enhanced intravascular guidewire with antibacterial function provided by an embodiment of the present invention.

[0027] Figure 2 This is a cross-sectional view of an ultrasound-enhanced intravascular guidewire with antibacterial function provided by an embodiment of the present invention.

[0028] Figure 1 Middle: 1. Guidewire base; 2. Nano silver ion plating. DETAILED DESCRIPTION

[0029] In order to make the purpose, technical solution and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with the embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0030] like Figure 1 , Figure 2 As shown, an ultrasound-enhanced intravascular guidewire with antibacterial function provided by an embodiment of the present invention includes:

[0031] Guidewire base part 1, nano silver ion plating layer 2;

[0032] The surface of the guide wire base part 1 is plated with a uniform nano silver ion plating layer 2; the nano silver ion plating layer is uniformly attached to the surface of the guide wire through an electroplating or chemical plating process, and the thickness is controlled between 1-2 microns.

[0033] The guidewire base part 1 provided in the embodiment of the present invention includes:

[0034] The base part of the guide wire is made of high-strength alloy or stainless steel material; the base part is designed to be slender and flexible.

[0035] The guidewire base portion 1 provided in the embodiment of the present invention is generally circular or an elongated linear structure, and its design meets the requirements of vascular interventional surgery.

[0036] The two ends of the guidewire base portion 1 provided in the embodiment of the present invention may be designed to be tapered or pointed.

[0037] The guidewire base portion 1 provided in the embodiment of the present invention can be connected to ultrasound equipment and other image-guided equipment, and connected to a monitoring system via a cable or wireless data transmission to ensure real-time display of the positioning of the guidewire in the body.

[0038] The surface of the guidewire base portion 1 provided in the embodiment of the present invention may also be embedded with sensors including pressure sensors or temperature sensors.

[0039] The surface of the guide wire base part 1 is plated with a nano silver ion coating 2, which is evenly covered on the surface of the guide wire base part by electroplating or chemical plating, and the thickness is controlled between 1-2 microns. The nano silver ion coating has a strong broad-spectrum antibacterial function and can achieve the antibacterial effect through the following mechanisms:

[0040] Nanosilver ions destroy the integrity of the cell wall by binding to proteins on the bacterial cell wall or membrane;

[0041] Nanosilver ions penetrate into cells and interfere with bacterial DNA replication and protein synthesis;

[0042] Reactive oxygen species (ROS) can be generated during the release of nanosilver, further destroying the bacterial cell structure and preventing bacterial reproduction.

[0043] The guidewire base part 1 is made of high-strength alloy or stainless steel material, and is designed to be slender and flexible to meet the complex requirements of vascular interventional surgery:

[0044] High-strength materials ensure that the guidewire will not break or bend during advancement;

[0045] The elongated morphology matches the shape of the vascular lumen, enabling smooth entry and navigation into the complex vascular network;

[0046] The conical or pointed shape design further reduces the intravascular resistance and reduces damage to the vascular endothelium.

[0047] The guidewire base part 1 can be connected to an ultrasound device to guide its real-time positioning in the blood vessel using ultrasound:

[0048] The guidewire converts the external ultrasonic signal into a vibration signal inside the guidewire through the built-in high-frequency vibration transducer;

[0049] Ultrasound guidance can achieve high-precision imaging within blood vessels, helping doctors to view the positioning and path of the guidewire in real time;

[0050] Ultrasound can also reduce intravascular resistance to a certain extent and improve the advancement efficiency of the guidewire.

[0051] The guidewire base part 1 is connected to the monitoring system via a cable or wirelessly to ensure that the position of the guidewire is displayed in real time during the operation:

[0052] The built-in pressure sensor is used to monitor the resistance of the guidewire in the blood vessel and provide timely feedback to the doctor to prevent the guidewire from puncturing the blood vessel wall.

[0053] Temperature sensors are used to monitor temperature changes in the environment surrounding the guidewire during surgery to help identify abnormal conditions such as local infection or tissue damage.

[0054] The nano silver ion plating layer is evenly distributed on the surface of the guide wire through a precise process:

[0055] The thickness of the coating (1-2 microns) ensures the durability of the antibacterial function without significantly increasing the diameter of the guidewire;

[0056] The uniform design ensures that the guide wire will not have local coating peeling due to friction during use, thereby maintaining the antibacterial properties for a long time.

[0057] The guidewire significantly improves the safety and efficiency of vascular interventional surgery by combining its high strength, flexibility, antibacterial properties and image guidance:

[0058] The antibacterial function reduces the risk of postoperative infection and improves the patient's postoperative recovery quality;

[0059] The combined effect of ultrasound enhancement and embedded sensors enables doctors to monitor the status of the guidewire and the surgical process in real time to avoid unexpected risks;

[0060] The guidewire design optimizes the advancement path, reduces operation time and damage to the patient's blood vessels, and achieves a dual improvement in surgical efficiency and effectiveness.

[0061] The ultrasound-enhanced intravascular guidewire of the present invention comprises the following main parts:

[0062] 1. Guidewire base part:

[0063] The base part of the guidewire is made of high-strength alloy or stainless steel to ensure that the guidewire has sufficient flexibility and strength to be smoothly operated and guided in the blood vessel. The base part is designed to be slender and flexible so that it can be easily operated in complex vascular environments.

[0064] 2.Nano silver ion plating:

[0065] The surface of the guide wire is coated with a uniform layer of silver nanoparticles. The silver nanoparticles are evenly attached to the surface of the guide wire through electroplating or chemical plating, and the thickness is controlled between 1-2 microns. The nano silver ion layer enhances the development effect of the guide wire under ultrasound by increasing the acoustic impedance, which significantly improves the contrast and clarity of the guide wire in the ultrasound image.

[0066] The thin film formed by silver nanoparticles on the surface of the guidewire can effectively reflect ultrasound, significantly improve the ultrasonic visibility of the guidewire, and enhance the clarity of the guidewire in the ultrasound image, making it easier for doctors to operate and position more accurately during vascular interventional surgery.

[0067] 3. Antibacterial functional layer:

[0068] In addition to enhancing the visibility of ultrasound images, nano silver ions also have strong antibacterial properties. Silver ions can effectively inhibit the growth of bacteria and prevent infection during vascular interventional surgery. Silver ions bind to bacterial cell membranes and destroy the cell membrane structure, thereby inhibiting bacterial proliferation and biofilm formation, effectively reducing the risk of infection and ensuring patient safety.

[0069] In addition, the uniform distribution of silver ions on the guide wire surface ensures the continuity and durability of the antibacterial effect, providing protection for prolonged surgical procedures.

[0070] 4. Appearance design:

[0071] The shape of the guidewire is usually round or slender, and the design meets the needs of vascular interventional surgery. The surface is smooth and has no sharp corners to reduce damage and irritation to the inner wall of the blood vessel.

[0072] Both ends of the guide wire can be designed to be tapered or pointed to facilitate smooth entry into blood vessels and guide other interventional tools.

[0073] 5. Connection and control system:

[0074] The guidewire can be connected to ultrasound equipment and other image-guided devices, and connected to the monitoring system via cables or wireless data transmission to ensure real-time display of the positioning of the guidewire in the body.

[0075] In addition to the external control system, sensors (such as pressure sensors or temperature sensors) can also be embedded on the surface of the guidewire to monitor the status of the guidewire in real time.

[0076] Summary: The ultrasound-enhanced intravascular guidewire significantly improves the visibility and clarity under ultrasound through nano-silver ion plating, and at the same time uses the antibacterial properties of silver ions to effectively reduce the risk of infection during surgery. Its unique structural design ensures high-precision positioning, flexibility and safety of the guidewire, and is suitable for various vascular interventional surgeries, especially in complex vascular environments, and can provide better visualization guidance and operation safety guarantees.

[0077] Example 1: Ultrasound-enhanced intravascular guidewire for coronary intervention

[0078] background:

[0079] During coronary intervention, doctors need to use a guidewire to locate and guide the catheter into the coronary artery. Since the guidewire is thin and usually made of traditional materials, it is difficult to clearly display it through ultrasound images, which increases the difficulty and risk of the operation.

[0080] Implementation steps:

[0081] 1. Guidewire production: Medical standard guidewire is used as the base material, and the outer layer of the guidewire is plated with a layer of silver nanoparticles. The silver nanoparticles are evenly covered on the surface of the guidewire through the electroplating process, and the coating thickness is controlled between 1-2 microns.

[0082] 2. Ultrasound enhancement effect: Under ultrasound guidance, the guidewire of the present invention is used for coronary artery intervention. Since silver nanoparticles can effectively reflect ultrasound waves, the guidewire shows obvious contrast in the ultrasound image, allowing doctors to accurately track the movement of the guidewire in real time, avoiding the problem of difficult-to-identify position of traditional guidewires.

[0083] 3. Antibacterial effect: Silver ions have natural antibacterial effects, which can effectively inhibit possible bacterial infections during surgery and reduce the risk of postoperative infection for patients, especially during long operations.

[0084] Effect: Through this ultrasound-enhanced intravascular guidewire, doctors can perform coronary artery intervention more accurately under ultrasound guidance, reduce operation time, and improve the success rate of the operation. The antibacterial effect of silver nanoparticles effectively reduces the risk of infection.

[0085] Example 2: Ultrasound-enhanced intravascular guidewire for neurointerventional surgery

[0086] background:

[0087] Neurointerventional surgery usually requires the use of guidewires to precisely reach the brain or spinal nerves for minimally invasive treatment. Due to the complexity of nerves and blood vessels and the narrow space, guidewire positioning under ultrasound imaging is very important, but the display effect of traditional guidewires in ultrasound images is poor.

[0088] Implementation steps:

[0089] 1. Guidewire production: High elastic alloy material is selected as the guidewire substrate, and a layer of silver nanoparticles is evenly plated on its surface by solution method. By controlling the concentration of silver ions and the thickness of the coating, it is ensured that the guidewire has good ultrasonic reflection effect while maintaining its softness and high strength.

[0090] 2. Ultrasound enhancement effect: During neurointerventional surgery, the guidewire of the present invention is inserted into the neurovascular system using ultrasound imaging guidance. Due to the addition of silver nanoparticles, the guidewire shows a clear outline in the ultrasound image, and the doctor can guide the guidewire more accurately in a small space and ensure the correct placement of the guidewire through real-time image monitoring.

[0091] 3. Antibacterial effect: Silver ions can effectively inhibit the growth of bacteria, especially in neurointerventional surgery. Long-term contact with nerve tissue and blood vessels may lead to infection. The use of the guide wire of the present invention can significantly reduce this risk and ensure the safety of the operation.

[0092] Effect: The guidewire of the present invention not only improves surgical accuracy through ultrasound guidance in neurointerventional surgery, but also reduces the risk of surgical infection through the antibacterial properties of silver nanoparticles, thereby ensuring the safety of patients and the success of the operation.

[0093] The above description is only a specific implementation mode of the present invention, but the protection scope of the present invention is not limited thereto. Any modifications, equivalent substitutions and improvements made by any technician familiar with the technical field within the technical scope disclosed by the present invention and within the spirit and principle of the present invention should be covered by the protection scope of the present invention.

Claims

1. An ultrasound-enhanced intravascular guidewire with antibacterial function, characterized in that: include: Guidewire base part, nano silver ion plating layer; The surface of the base part of the guide wire is plated with a uniform nano silver ion coating; The nano silver ion plating layer is evenly attached to the surface of the guide wire through electroplating or chemical plating process, and the thickness is controlled between 1-2 microns.

2. The ultrasound-enhanced intravascular guidewire with antibacterial function as claimed in claim 1, characterized in that: The guidewire base portion: The base part of the guide wire is made of high-strength alloy or stainless steel material; the base part is designed to be slender and flexible.

3. The ultrasound-enhanced intravascular guidewire with antibacterial function as claimed in claim 1, characterized in that: The guidewire base portion is generally circular or slender linear in shape, and is designed to meet the requirements of vascular interventional surgery.

4. The ultrasound-enhanced intravascular guidewire with antibacterial function as claimed in claim 1, characterized in that: Both ends of the guidewire base portion may be designed to be tapered or pointed.

5. The ultrasound-enhanced intravascular guidewire with antibacterial function as claimed in claim 1, characterized in that: The guidewire base portion can be connected to ultrasound equipment and other image-guided equipment, and connected to a monitoring system via a cable or wireless data transmission to ensure real-time display of the positioning of the guidewire in the body.

6. The ultrasound-enhanced intravascular guidewire with antibacterial function as claimed in claim 1, characterized in that: The surface of the guidewire base portion may also be embedded with sensors including pressure sensors or temperature sensors.

7. A method for preparing an ultrasonically enhanced intravascular guidewire having antibacterial function based on the ultrasonically enhanced intravascular guidewire according to claim 1, characterized in that: The method comprises the following steps: a) providing a guidewire base portion made of a high-strength alloy or stainless steel; b) removing impurities from the guidewire base portion through a surface cleaning and pretreatment process; c) using electroplating or chemical plating process to evenly attach a nano silver ion plating layer on the surface of the guide wire base portion, and controlling the thickness of the plating layer to be 1-2 microns; d) drying the guide wire coated with the nano silver ion layer to ensure uniformity and adhesion of the coating; e) Testing the antibacterial properties and coating adhesion quality of the guide wire to ensure that they meet the preset performance indicators.

8. An antibacterial method for optimizing the surface coating of the ultrasonically enhanced intravascular guidewire according to claim 1, characterized in that: The method comprises the following steps: a) Selecting a guidewire substrate material having electrical conductivity and smooth surface characteristics; b) using an electroplating device to evenly spray the nano silver ion suspension onto the surface of the guide wire, and optimizing the thickness of the coating by adjusting the electroplating current and time; c) real-time monitoring of the surface potential of the coating during the electroplating process to ensure uniform distribution of the nanosilver ion coating; d) Place the coated guide wire in a constant temperature drying environment, and control the drying time and temperature to enhance the coating performance; e) Test its antibacterial effect on the guide wire surface and evaluate the antibacterial performance using specific strains.

9. An assembly and detection method for ultrasound-enhanced intravascular guidewire according to claim 1, characterized in that: The method comprises the following steps: a) processing the two ends of the guide wire substrate plated with the nano silver ion coating into a cone or a tip shape; b) Integrate a pressure sensor or temperature sensor on the surface of the guidewire and ensure stable attachment of the sensor through implantation or bonding technology; c) Connect the guidewire to the ultrasound device via a cable or wireless module to ensure real-time data transmission; d) Test the antibacterial properties, ultrasonic signal enhancement effect and sensor sensitivity of the guidewire in a simulated vascular environment; e) Optimize the guidewire structure and surface properties based on the test results, and ultimately form a finished guidewire that can be used in vascular interventional surgery.

Images