Medical equipment and electric connection detection system thereof

Abstract

The invention discloses medical equipment and an electric connection detection system thereof, the medical equipment at least comprises a card box and a card box bin, the card box is provided with a printed circuit board, and the printed circuit board comprises a first surface used for realizing an electrowetting function and driving liquid drops to move and a second surface corresponding to the first surface. The first surface is provided with a plurality of groups of electrode pairs; the second surface is provided with a plurality of bonding pad pairs and a plurality of signal coupling wire pairs; one end of the signal coupling wire pair is connected with the pad pair, and the other end is connected with the electrode pair. According to the card box, the electric connection between the bonding pad pair and the electrode pair is achieved through the signal coupling pair comprising the parallel wires, the coupling voltage can be improved through the wire pair, the impedance value is reduced, the difference between the impedance value of the normal electrode pair and the impedance value of the abnormally connected electrode is increased, and the reliability of the card box is improved. In this way, the medical equipment can easily detect abnormal electrodes, and detection errors and reagent waste are avoided.

Description

Technical Field

[0001] The present application relates to the technical field of instruments and meters, and more specifically, to a medical device and an electrical connection detection system thereof. Background Art

[0002] Microfluidics is also known as micro-total analysis system and chip laboratory. Microfluidics chips have the advantages of miniaturization, high throughput, small sample requirements, and faster speed. The development of dielectric electrowetting technology has promoted the commercialization of microscale liquid handling technology based on printed circuit board (PCB) digital microfluidics.

[0003] A general electrical connection detection system usually includes one or more card cartridge compartments and a corresponding control unit. The card cartridge compartment is used to accommodate the inserted card cartridge, and the electrical connection between the card cartridge and the card cartridge compartment is achieved through spring pins. The control unit also includes a central processing module and a display interface. The central processing module is used to control the insertion and ejection of the card cartridge and the collection and processing of data, and the display interface is used to display the detection process and results.

[0004] The lower area of ​​the cartridge is provided with a printed circuit board for electrowetting to drive the movement of liquid. The top layer of the printed circuit board includes a plurality of different electrodes for realizing electrowetting and driving the movement of liquid. The bottom of the printed circuit board is electrically connected to the cartridge compartment through spring pins. The central processing unit provides electrical signals to the electrodes on the printed circuit board through the spring pins. If the electrical connection between the cartridge compartment and the cartridge is incorrect, the correct electrical signals cannot be provided to the electrodes on the cartridge, which will cause the electrowetting drive to fail, and the detection system will not be able to correctly process the reagent, resulting in detection errors and waste of reagents.

[0005] To avoid detection errors, it is necessary to perform a preliminary self-test after the card cartridge is inserted into the card cartridge compartment, but before the device officially starts the test, to evaluate whether the correct electrical connection has been achieved between the card cartridge and the card cartridge compartment. After the self-test is completed, the reagent test should be performed to avoid detection errors and waste of reagents. Summary of the invention

[0006] In view of this, the present application provides a medical device and an electrical connection detection system thereof, which are used to avoid detection errors of reagents and waste of reagents.

[0007] In order to achieve the above objectives, the proposed solution is as follows:

[0008] A medical device, characterized in that it comprises a card box, the card box is configured with a printed circuit board, the printed circuit board comprises a first surface for realizing an electrowetting function and driving a droplet to move, and a second surface corresponding to the first surface, wherein:

[0009] The first surface is provided with a plurality of electrode pairs;

[0010] The second surface is provided with a plurality of pad pairs and a plurality of signal coupling wire pairs;

[0011] One end of the signal coupling wire pair is connected to the pad pair, and the other end is connected to the electrode pair.

[0012] Optionally, each of the coupled wire pairs includes two wires arranged in parallel, and the distance between the two wires is kept constant and the lengths are equal.

[0013] Optionally, the distance between the two wires is 4 mil-12 mil.

[0014] Optionally, the length of the parallel wire pair is greater than 20 mm.

[0015] An electrical connection detection system is applied to the above-mentioned medical device, the electrical connection detection system comprises a card box compartment and a control unit connected to the card box compartment, wherein:

[0016] The card box compartment is used to carry the inserted card box, and includes a plurality of probes, and the probes are connected to the corresponding pads for signal connection;

[0017] The control unit is used to output a high-frequency voltage signal to the probe, and is also used to process a feedback signal fed back by the probe to obtain a detection result.

[0018] Optionally, the probe is a spring probe or a test probe.

[0019] Optionally, the control unit includes a signal acquisition circuit and a signal processing module, wherein:

[0020] The signal acquisition circuit is used to collect the feedback signal and output the feedback signal to the signal processing module;

[0021] The signal processing module is used to process the feedback signal to obtain the detection result.

[0022] Optionally, the signal acquisition circuit includes:

[0023] A high voltage resistant capacitor having one end connected to the probe signal;

[0024] A clamping diode having a cathode connected to the other end of the high voltage capacitor, wherein the anode of the clamping diode is grounded;

[0025] A multiplexing switch having an input terminal connected to the cathode of the clamping diode;

[0026] a high-speed operational amplifier having a non-inverting input terminal connected to the output terminal of the multiplexing switch, and an inverting input terminal of the high-speed operational amplifier connected to the output terminal;

[0027] A second-order bandpass filter having one end connected to the output end of the high-speed operational amplifier;

[0028] A signal acquisition and processing chip whose input end is connected to the other end of the second-order bandpass filter.

[0029] It can be seen from the above technical solution that the present application discloses a medical device and an electrical connection detection system thereof, the medical device comprising a card box and a card box compartment, the card box is provided with a printed circuit board, the printed circuit board comprises a first surface for realizing the electrowetting function and driving the movement of droplets and a second surface corresponding to the first surface. The first surface is provided with multiple groups of electrode pairs; the second surface is provided with multiple pad pairs and multiple signal coupling wire pairs; one end of the signal coupling wire pair is connected to the pad pair, and the other end is connected to the electrode pair. The card box in the present application utilizes a signal coupling wire pair including parallel wires to realize the electrical connection between the pad pair and the electrode pair. The wire pair can increase the coupling voltage and reduce the impedance value, so that the impedance value of the normal electrode pair is increased compared with the impedance value of the abnormally connected electrode, so that the system can more easily detect the abnormal electrode, avoid detection errors and waste of reagents. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0031] Figure 1 A schematic diagram of a first surface of a printed circuit board of a card box according to an embodiment of the present application;

[0032] Figure 2 A schematic diagram of a second surface of a printed circuit board of a card box according to an embodiment of the present application;

[0033] Figure 3 This is a schematic diagram of electrical connections of a printed circuit board of a card box according to an embodiment of the present application;

[0034] Figure 4 This is a detection flow chart of the electrical connection detection system in the embodiment of the present application;

[0035] Figure 5 are impedance values ​​of different electrode pairs of the same card box in the embodiment of the present application;

[0036] Figure 6 A schematic diagram of a signal acquisition circuit according to an embodiment of the present application. DETAILED DESCRIPTION

[0037] The following will be combined with the drawings in the embodiments of the present application to clearly and completely describe the technical solutions in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0038] Figure 1 This is a schematic diagram of a printed circuit board of a card box according to an embodiment of the present application.

[0039] The present embodiment provides a medical device, which includes a card box and a card box compartment for accommodating the card box, and the medical device also includes an electrical connection detection system. The card box is used to carry specific reagents including biological reagents, chemical reagents, etc., so that the medical device can detect the reagents. The card box includes a shell and a printed circuit board arranged in the shell. Generally speaking, a printed circuit board is an insulating substrate on which corresponding wires, electrodes, contacts, etc. are laid, and its shape is generally a flat plate with an upper and lower surface. In general application scenarios, the upper, lower, front and back sides are not of practical significance, so the two surfaces are referred to as the first surface and the second surface in this application.

[0040] A plurality of electrode pairs 20 are arranged on the first surface of the printed circuit board 10. Figure 1 As shown, the so-called electrode pair includes two electrodes. The electrode pairs are arranged in pairs according to a certain rule and order. When the card box is inserted into the card box compartment, the electrical connection detection system performs a pre-self-test on the electrode pairs in the card box to determine whether each electrode of the card box is truly electrically connected to the card box compartment. After the self-test is completed, when the card box is used to realize droplet drive, the reagent droplets are on the electrodes, and each electrode does not affect each other, and each performs a corresponding function. According to needs, the reagent droplets can be controlled to move along the electrodes on the printed circuit board according to the specified rules and speed.

[0041] A plurality of pad pairs 30 and a plurality of signal coupling conductor pairs 40 are arranged on the second surface of the printed circuit board. Figure 2 The signal coupling wire pair is used to connect the corresponding pads to the electrode pairs together, as shown in FIG. Figure 3 As shown. One end of the signal coupling wire pair is connected to the pad pair, and the other end is connected to the electrode pair. In addition, the electrode pair, the signal coupling wire pair and the pad pair in the present application can be arranged on the same side of the printed circuit board, that is, all arranged on the first surface or all arranged on the second surface, so as to reduce the processing difficulty on the basis of meeting the functional requirements and reduce the processing cost.

[0042] The signal coupling wire pair in the present application includes two parallel wires, and the lengths of the two wires are consistent. The parallel arrangement here means that the distance between the two wires arranged on the printed circuit board remains constant at any position. And the lengths of all signal coupling wires arranged on the printed circuit board are consistent. In the present application, the distance between the two wires is 4mil-12mil; the length of the parallel wire pair is greater than 20 mm.

[0043] There are technologies that only rely on the coupling of electrodes and upper plates or the generation of voltage signals or current signals between two electrodes to test the impedance size. For example, due to the design of electrodes below 5MM, the coupling signal is too small and easily interfered, and due to process limitations, the impedance values ​​of the upper plates vary greatly and are difficult to unify. When the spring pin is not in sufficient contact due to dust or spring elasticity failure, the impedance value changes very little relative to a relatively large impedance value and is not easy to detect. Even if the impedance value data is refitted or other algorithms are processed, there is still a considerable error, which leads to incorrect detection results. In addition, there are differences and variability between card box compartments and between printed circuit boards (PCBs) on card boxes. For example, when a card box is inserted into a certain card box compartment and operates normally, a measurement value (voltage or impedance) may be equal to a measurement value generated by another card box with a poor connection to the card box compartment. Therefore, the measured values ​​generated between different card boxes and between card box compartments cannot represent the good or bad results. It is possible that the card box and the card box compartment are allowed to operate with poor connection, and the good connection cannot operate, resulting in greater waste or errors.

[0044] In this application, equal length routing is adopted, the two wires of the signal coupling wire pair are equal in length, and the signal coupling wire pairs of different electrode pairs are also equal in length, which ensures that the impedance data of each pair of electrodes in the card box are equal or similar. In actual testing, different card boxes are tested, and the average value and precision of the impedance value of each pair of electrodes in the same card box are within 5‰ of the average value, as shown in the following table.

[0045]

[0046]

[0047] When droplet driving is performed, each electrode does not affect each other and each performs its corresponding function. When pre-detection is performed, each two electrodes are combined into a pair, in which a spring pin of a spring connector sends a square wave driving signal with a frequency between 1K-100K and a peak-to-peak voltage of 60-300V. The driving circuit is called the driving end. The driving signal passes through the signal coupling wire pair to the other electrode (the other electrode of the electrode pair). The sensing circuit is collectively referred to as the detection end. The detection end obtains a coupled voltage signal, which is transmitted through the detection end wiring to the pad contacted by the spring pin, and then transmitted from the pad to the signal processing circuit through the spring pin. After filtering, gain processing and digital-to-analog conversion of the detection end voltage signal, an equal or similar impedance data is obtained. The impedance data generated by each pair of electrodes on the card box printed circuit board is organized to form a data stream. Analyze the data stream and calculate the standard deviation of the data stream. When the standard deviation is greater than the set value, it can be judged that the impedance value of the card box is abnormal and there is no normal connection with the device.

[0048] In the specific test, the Figure 4 In the process shown, the signal generator of the control unit of the detection system provides a high-frequency voltage square wave signal, which is connected to the printed circuit board trace through the spring pin and transmitted to the electrode of the card box. The high-frequency voltage signal is coupled to another printed circuit board trace on the printed circuit board trace to generate a voltage signal of the same frequency, which is transmitted to another spring pin through the printed circuit board trace. The voltage signal is transmitted to the processing chip through the spring pin to obtain a voltage value or impedance value. For example, if the data exceeds the normal threshold, it can be determined that one or both electrodes in the pair of electrodes may have a problem. At this time, the card box can be reinserted into the same card box compartment or another card box compartment for detection. If the electrode data at the same position also exceeds the normal threshold, it can be determined that the card box is damaged.

[0049] The voltage coupling signal Vvictim and the driving line voltage signal V aggressor The relationship between them is shown in the following formula:

[0050]

[0051] Where K is a constant whose value is always less than 1 and depends on the rise time of the circuit and the length of the PCB parallel trace. 2 is the product of the heights of the parallel wires, D 2 It is the product of the direct distances between the center lines of parallel conductors.

[0052] like Figure 5As shown, in the entire data stream, there are two points that are the impedance values ​​when the electrode pair is not connected normally. In the specific implementation, the standard deviation of the entire data stream is greater than the set value or the two largest data are screened out, and the standard deviation is calculated again. If the standard deviation is less than the set value, it can be determined that the card box and the device are not normally electrically connected. This method ensures that the differences between different card boxes will not affect the judgment of specific values. Each data becomes predictable, and there is no need to sort the data stream again, which improves the accuracy, simplicity, and precision of the judgment.

[0053] It can be seen from the above technical scheme that the present application provides a medical device and its electrical connection detection system. The series of systems at least include a card box and a card box compartment. The card box is provided with a printed circuit board. The printed circuit board includes a first surface for realizing the electrowetting function and driving the movement of droplets and a second surface corresponding to the first surface. The first surface is provided with multiple groups of electrode pairs; the second surface is provided with multiple pad pairs and multiple signal coupling wire pairs; one end of the signal coupling wire pair is connected to the pad pair, and the other end is connected to the electrode pair. The card box in the present application uses a signal coupling wire pair including parallel wires to realize the electrical connection between the pad pair and the electrode pair. The wire pair can increase the coupling voltage and reduce the impedance value, so that the impedance value of the normal electrode pair is increased compared with the impedance value of the abnormally connected electrode. In this way, the system can easily detect abnormal electrodes and avoid detection errors and waste of reagents.

[0054] In addition, the present application also provides an electrical connection detection system, which includes a card box compartment for accommodating the above-mentioned card box and a control unit connected to the card box compartment. The card box compartment is provided with multiple groups of probes, which can be spring probes or test probes, and are used to connect with the pads when the card box is inserted. The control unit is used to input a high-frequency voltage signal to the probe through its signal generating circuit, and obtain a detection result based on the obtained feedback signal. The control unit includes at least a signal acquisition circuit and a signal processing circuit, the signal acquisition circuit is used to collect feedback signals of different electrode pairs, and the signal processing circuit is used to process the feedback signal to obtain the detection result.

[0055] The signal acquisition circuit includes a high voltage capacitor C, a clamping diode TVS, a multiplexing switch 102, a high speed operational amplifier 103, a second order band pass filter 201 and a signal acquisition processing chip 202. Figure 6As shown. One end of the high-voltage capacitor is used as a signal input terminal 101, which is used to connect to different probes. The other end of the high-voltage capacitor is connected to the cathode of the clamping diode, the anode of the clamping diode is grounded, and the other end of the high-voltage capacitor or the cathode of the clamping diode is also connected to an input end of the multiplexer. The positive input terminal of the high-speed operational amplifier is connected to the output terminal of the multiplexer, and the inverting input terminal and the output terminal of the high-speed operational amplifier are connected to form a feedback circuit. The output terminal of the high-speed operational amplifier is connected to one end of the second-order bandpass filter, and the other end of the second-order bandpass filter is connected to the signal acquisition and processing chip.

[0056] The voltage-resistant capacitor can effectively remove DC and low-frequency voltage signals, and the clamping diode is used to protect the multiplexer switch chip from being damaged by high-voltage signals. The single-channel on-resistance of the multiplexer switch chip is 4 ohms, the resistance flatness is 0.5Ω, and the leakage current is only 1nA. The high-speed operational amplifier forms a voltage follower, which can theoretically make the input impedance infinite and the output impedance infinitesimal, which can effectively reduce the loss of the coupled voltage signal in the previous circuit and improve the load capacity of the circuit. The second-order bandpass filter is a second-order filter composed of an operational amplifier, a capacitor, and a resistor, which can effectively filter out power frequency interference signals and their clutter signals. After the signal is collected, it is directly processed by the single-chip microcomputer or by the AD chip or the impedance chip and then processed by the single-chip microcomputer, and the original voltage value after the collection and interference removal is converted into impedance data.

[0057] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0058] Although the preferred embodiments of the present invention have been described, those skilled in the art may make additional changes and modifications to these embodiments once they have learned the basic creative concept. Therefore, the appended claims are intended to be interpreted as including the preferred embodiments and all changes and modifications that fall within the scope of the embodiments of the present invention.

[0059] Finally, it should be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or terminal device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or terminal device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the existence of other identical elements in the process, method, article or terminal device including the elements.

[0060] The technical solution provided by the present invention is introduced in detail above. Specific examples are used in this article to illustrate the principle and implementation mode of the present invention. The description of the above embodiments is only used to help understand the method of the present invention and its core idea. At the same time, for those skilled in the art, according to the idea of ​​the present invention, there will be changes in the specific implementation mode and application scope. In summary, the content of this specification should not be understood as limiting the present invention.

Claims

1. A medical device, characterized in that: The card box is provided with a printed circuit board, the printed circuit board includes a first surface for realizing the electrowetting function and driving the movement of droplets and a second surface corresponding to the first surface, wherein: The first surface is provided with a plurality of electrode pairs; The second surface is provided with a plurality of pad pairs and a plurality of signal coupling wire pairs; One end of the signal coupling wire pair is connected to the pad pair, and the other end is connected to the electrode pair.

2. The medical device according to claim 1, characterized in that Each of the coupled wire pairs includes two wires arranged in parallel, and the distance between the two wires is kept constant and the lengths are equal.

3. The medical device according to claim 2, characterized in that The distance between the two wires is 4mil-12mil.

4. The medical device according to claim 2, characterized in that The length of the parallel wire pair is greater than 20 mm.

5. An electrical connection detection system, applied to the medical device according to any one of claims 1 to 4, characterized in that: The electrical connection detection system comprises a card box compartment and a control unit connected to the card box compartment, wherein: The card box compartment is used to carry the inserted card box, and includes a plurality of probes, and the probes are connected to the corresponding pads for signal connection; The control unit is used to output a high-frequency voltage signal to the probe, and is also used to process a feedback signal fed back by the probe to obtain a detection result.

6. The electrical connection detection system according to claim 5, characterized in that: The probe is a spring probe or a test probe.

7. The electrical connection detection system according to claim 5, characterized in that: The control unit includes a signal acquisition circuit and a signal processing module, wherein: The signal acquisition circuit is used to collect the feedback signal and output the feedback signal to the signal processing module; The signal processing module is used to process the feedback signal to obtain the detection result.

8. The electrical connection detection system according to claim 7, characterized in that: The signal acquisition circuit comprises: A high voltage resistant capacitor having one end connected to the probe signal; A clamping diode having a cathode connected to the other end of the high voltage capacitor, wherein the anode of the clamping diode is grounded; A multiplexing switch having an input terminal connected to the cathode of the clamping diode; a high-speed operational amplifier having a non-inverting input terminal connected to the output terminal of the multiplexing switch, and an inverting input terminal of the high-speed operational amplifier connected to the output terminal; A second-order bandpass filter having one end connected to the output end of the high-speed operational amplifier; A signal acquisition and processing chip whose input end is connected to the other end of the second-order bandpass filter.

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