Chromatographic detector dedicated flow cell

Abstract

The invention discloses a special flow cell for a chromatographic detector, which relates to the technical field of detection equipment, and comprises: a closed shell, wherein a flow plate is fixedly installed inside the shell; a plurality of flow slots which are distributed in parallel and pass through from top to bottom are provided in the flow plate, and the widths of the flow slots increase successively; a quartz plate is tightly fitted on the upper and lower surfaces of the flow plate; a liquid inlet and a liquid outlet which are distributed front and back are provided on one side of the shell; a receiver and an optical fiber transmitter which are distributed up and down are provided on the other side of the shell; a reflector is provided on the upper and lower surfaces inside the shell corresponding to each flow slot; the invention has the beneficial effects of strong adaptability, high-precision detection, and automatic and precise control.

Description

Technical Field

[0001] The invention relates to the technical field of detection equipment, in particular to a special flow cell for a chromatographic detector. Background Art

[0002] Chromatograph is an efficient instrument for separation and analysis based on the difference in distribution coefficients between stationary phase and mobile phase. In the chromatography system, the flow cell is a key component connecting the chromatographic column and the detector. It has the important task of introducing the separated sample components into the detector and making them interact with the detector. The design of the flow cell directly affects the sensitivity and accuracy of the detection. The ideal flow cell should have the characteristics of good optical transparency and short sample retention time to ensure the stability and reliability of the detection signal.

[0003] In the prior art, the circulation cell of the chromatographic detector usually adopts a single-channel design, that is, each circulation cell is only suitable for a specific type of sample or specific detection conditions. Different circulation cells need to be replaced for samples with different chemical properties and physical properties. This not only increases the complexity of the operation, but also may cause time delays and error accumulation during the detection process. Especially in high-throughput detection scenarios, frequent replacement of circulation cells will seriously affect the detection efficiency. In the design of multi-channel circulation cells, due to the possible slight deviations between channels, it is difficult to accurately align the optical signal with different channels, which not only reduces the detection sensitivity.

[0004] Therefore, it is necessary to provide a dedicated flow cell for a chromatographic detector to solve the problems raised in the above background technology. Summary of the invention

[0005] To achieve the above object, the present invention provides the following technical solution: a special flow cell for a chromatographic detector, comprising:

[0006] A closed housing, wherein a flow plate is fixedly installed inside the housing;

[0007] The circulation plate is provided with a plurality of circulation grooves which are parallelly distributed and pass through from top to bottom, and the widths of the circulation grooves increase sequentially;

[0008] The upper and lower surfaces of the circulation plate are both tightly attached to a quartz plate;

[0009] One side of the shell is provided with a liquid inlet and a liquid outlet distributed front and back;

[0010] The other side of the housing is provided with a receiver and an optical fiber transmitter distributed up and down;

[0011] The upper surface and the lower surface of the shell are both provided with a reflector corresponding to each flow slot.

[0012] Furthermore, a liquid inlet pipe and a liquid outlet pipe are respectively arranged at the front and rear of the circulation plate; the liquid inlet pipe and the liquid outlet pipe are respectively connected to the liquid inlet and the liquid outlet;

[0013] The liquid inlet pipe and the liquid outlet pipe are respectively communicated with each flow slot, and an electromagnetic valve is connected between the liquid inlet pipe and each flow slot.

[0014] Furthermore, a rotating shaft is fixed to one side of the reflector, and the rotating shaft is rotatably connected in the housing.

[0015] Furthermore, a torsion spring is arranged between the rotating shaft and the housing, and the torsion spring provides elastic force to make the reflector parallel to the flow plate.

[0016] Furthermore, a rotating rod is fixed to one end of the rotating shaft, and when the reflector is in a state parallel to the circulation plate, the rotating rod is inclined toward a direction close to the circulation plate;

[0017] Two slide rails distributed up and down are fixed on the back of the shell, and a slider is slidably arranged in each of the slide rails. The rotating rod is at the height of the corresponding slide rail, so that the slider can drive the corresponding reflector to rotate when passing through different rotating rods.

[0018] Furthermore, each of the sliders is fixed together by a nut, a screw is rotatably connected in the housing, and the screw is threadedly connected to the nut.

[0019] Furthermore, a servo motor is provided on one side of the housing, and the screw rod is connected to the servo motor.

[0020] Furthermore, it also includes a temperature control system, which includes a heating tube and a temperature sensor arranged inside the shell, and is used to adjust and maintain a constant temperature in the circulation pool to meet the needs of temperature-sensitive sample detection.

[0021] Furthermore, pressure sensors and flow meters are provided at the liquid inlet and outlet for real-time monitoring of the pressure and flow of the mobile phase sample to ensure the stability and accuracy of the detection process. The liquid outlet is connected to a water pump to ensure that the mobile phase in the circulation tank can be discharged from the liquid outlet.

[0022] Furthermore, the solenoid valve is an electrically controlled proportional valve, which can accurately control the flow rate of the mobile phase entering each flow slot to achieve more precise sample separation and detection control.

[0023] Compared with the prior art, the present invention has the following beneficial effects:

[0024] The flow cell of the present invention is designed with multiple flow slots with increasing widths, so that the flow cell can flexibly adapt to the detection needs of samples with different chemical properties and physical characteristics. By selecting flow slots of different widths, the separation effect and detection sensitivity of the samples can be optimized to meet the detection requirements of different samples.

[0025] The present invention can achieve minute angle adjustment of the reflector by precisely controlling the rotation angle of the screw through a servo motor, thereby ensuring that the optical signal can accurately pass through the designated flow slot and be received by the receiver, providing more precise sample separation and detection control for chromatographic analysis. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a schematic diagram of the overall structure of the dedicated flow cell for the chromatographic detector;

[0027] Figure 2 It is a schematic diagram of the internal three-dimensional structure of the special flow cell for chromatographic detector;

[0028] Figure 3 It is a schematic diagram of the cross-sectional structure of a dedicated flow cell for a chromatographic detector;

[0029] Figure 4 Schematic diagram of the arrangement structure of the reflector in the present invention;

[0030] Figure 5 It is a schematic diagram of the structure of the circulation plate in the present invention;

[0031] In the figure: 1. housing; 2. circulation plate; 21. circulation slot; 3. liquid inlet; 31. liquid inlet pipe; 32. solenoid valve; 4. liquid outlet; 41. liquid outlet pipe; 5. optical fiber transmitter; 6. receiver; 7. reflector; 71. rotating shaft; 72. rotating rod; 73. torsion spring; 8. slide rail; 9. slider; 10. nut; 11. screw rod; 12. servo motor. DETAILED DESCRIPTION

[0032] See also Figure 1-Figure 5 In an embodiment of the present invention, a dedicated flow cell for a chromatographic detector comprises:

[0033] A closed housing 1, wherein a circulation plate 2 is fixedly installed inside the housing 1;

[0034] The circulation plate 2 is provided with a plurality of parallel circulation slots 21 extending vertically and extending horizontally, and the width of the circulation slots 21 increases sequentially to meet the testing requirements of samples with different chemical and physical properties.

[0035] The upper and lower surfaces of the circulation plate 2 are closely attached with quartz plates for closing the circulation slot 21 and providing optical transparency;

[0036] One side of the housing 1 is provided with a liquid inlet 3 and a liquid outlet 4 distributed front and back for introducing and discharging mobile phase samples;

[0037] The other side of the housing 1 is provided with a receiver 6 and an optical fiber transmitter 5 distributed up and down;

[0038] A reflector 7 is provided on the upper and lower surfaces of the housing 1 corresponding to each flow slot 21 , and the reflector 7 is used to guide light to pass through the flow slot 21 , so that the receiver 6 receives the optical signal from the optical fiber transmitter 5 and reflected by the flow slot 21 and the reflector 7 .

[0039] Different samples have different chemical properties and physical characteristics, and have different requirements for circulation pools. The mobile phase can be introduced into circulation slots 21 of different widths according to the properties of the mobile phase sample to meet different detection needs. By aligning the receiver 6 and the optical fiber transmitter 5 with the corresponding reflector 7, the receiver 6 and the optical fiber transmitter 5 act on different circulation slots 21.

[0040] In this embodiment, a liquid inlet pipe 31 and a liquid outlet pipe 41 are respectively provided at the front and rear of the circulation plate 2; the liquid inlet pipe 31 and the liquid outlet pipe 41 are respectively connected to the liquid inlet port 3 and the liquid outlet port 4;

[0041] The liquid inlet pipe 31 and the liquid outlet pipe 41 are respectively communicated with each flow slot 21 , and a solenoid valve 32 is connected between the liquid inlet pipe 31 and each flow slot 21 .

[0042] The solenoid valve 32 can be used to control the mobile phase in the liquid inlet pipe 31 to enter one or more flow channels 21 .

[0043] In this embodiment, a rotating shaft 71 is fixed to one side of the reflector 7 , and the rotating shaft 71 is rotatably connected in the housing 1 .

[0044] The tilt angle of the reflector 7 can be adjusted by rotating the reflector 7 , so that the optical signal of the optical fiber transmitter 5 can pass through the corresponding flow slot 21 and can be received by the receiver 6 .

[0045] In this embodiment, a torsion spring 73 is disposed between the rotating shaft 71 and the housing 1 , and the torsion spring 73 provides an elastic force to make the reflector 7 parallel to the flow plate 2 .

[0046] Under the action of the torsion spring 73 , the reflector 7 is parallel to the flow plate 2 in a natural state, and at this time, it is unable to reflect the optical signal from the optical fiber transmitter 5 .

[0047] In this embodiment, a rotating rod 72 is fixed to one end of the rotating shaft 71 , and when the reflector 7 is in a state parallel to the circulation plate 2 , the rotating rod 72 is inclined toward a direction close to the circulation plate 2 .

[0048] The reflector 7 can be tilted by turning the rotating rod 72 without interfering with the propagation of the optical signal.

[0049] In this embodiment, two slide rails 8 distributed up and down are fixed on the back side of the shell 1, and a slider 9 is slidably arranged in each of the slide rails 8. The rotating rod 72 is at the height of the corresponding slide rail 8, so that the slider 9 can drive the corresponding reflector 7 to rotate when passing through different rotating rods 72.

[0050] In this embodiment, each of the sliders 9 is fixed together by a nut 10 , and a screw rod 11 is rotatably connected inside the housing 1 , and the screw rod 11 is threadedly connected to the nut 10 .

[0051] The slider 9 can be placed in different positions by rotating the screw rod 11 . When the slider 9 is in different positions, it drives the corresponding rotating rod 72 to rotate, thereby rotating the reflector 7 , so that the optical signal of the optical fiber transmitter 5 passes through the flow slot 21 at that position.

[0052] In this embodiment, a servo motor 12 is disposed on one side of the housing 1 , and the screw rod 11 is connected to the servo motor 12 .

[0053] The servo motor 12 is equipped with an encoder for real-time monitoring of the rotation position and speed of the servo motor to ensure accurate rotation and positioning of the reflector 7 .

[0054] In this embodiment, a temperature control system is also included. The temperature control system includes a heating tube and a temperature sensor arranged inside the housing 1, which are used to adjust and maintain a constant temperature in the circulation pool to meet the needs of temperature-sensitive sample detection.

[0055] In this embodiment, pressure sensors and flow meters are provided at the liquid inlet 3 and the liquid outlet 4 for real-time monitoring of the pressure and flow of the mobile phase sample to ensure the stability and accuracy of the detection process. The liquid outlet 4 is connected to a water pump to ensure that the mobile phase in the circulation slot 21 can be discharged from the liquid outlet 4.

[0056] In this embodiment, the solenoid valve 32 is an electrically controlled proportional valve, which can accurately control the flow rate of the mobile phase entering each flow slot 21 to achieve more precise sample separation and detection control.

[0057] In specific implementation, according to the chemical properties and physical characteristics of the sample to be tested, a suitable flow slot 21 is selected, and the width of the flow slot 21 increases successively to meet the testing requirements of samples with different properties;

[0058] In the initial state, the reflector 7 is parallel to the flow plate 2 under the action of the torsion spring 73 and does not reflect the light signal. The rotation angle of the screw 11 is precisely controlled by the servo motor 12, so that the slider 9 slides to the specified position on the slide rail 8, thereby driving the corresponding rotating rod 72 and the reflector 7 to rotate to the required angle;

[0059] The flow rate of the mobile phase entering the selected flow slot 21 is precisely controlled by the solenoid valve 32 to ensure that the mobile phase passes through the flow slot at a stable pressure and flow rate, so that the optical signal of the optical fiber transmitter 5 can pass through the corresponding flow slot 21 and be received by the receiver 6;

[0060] Start the chromatographic detector and begin sample detection. The optical fiber transmitter 5 sends out a light signal, which is reflected by the flow slot 21 and the reflector 7, received by the receiver 6 and converted into an electrical signal for processing and analysis. The composition and content of the sample are determined based on information such as peak shape, peak height, and peak area.

[0061] What is described above is only a preferred specific implementation manner of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can make equivalent replacements or changes according to the technical scheme and inventive concept of the present invention within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A special flow cell for a chromatographic detector, characterized in that: include: A closed housing (1), wherein a circulation plate (2) is fixedly installed inside the housing (1); The circulation plate (2) is provided with a plurality of circulation grooves (21) which are distributed in parallel and penetrate vertically, and the widths of the circulation grooves (21) increase sequentially; The upper and lower surfaces of the circulation plate (2) are both tightly fitted with a quartz plate; One side of the housing (1) is provided with a liquid inlet (3) and a liquid outlet (4) distributed front and back; The other side of the housing (1) is provided with a receiver (6) and an optical fiber transmitter (5) distributed vertically. The upper surface and the lower surface of the housing (1) are both provided with a reflector (7) corresponding to each flow slot (21); A rotating shaft (71) is fixed to one side of the reflector (7), and the rotating shaft (71) is rotatably connected inside the housing (1); A torsion spring (73) is provided between the rotating shaft (71) and the housing (1), and the torsion spring (73) provides an elastic force to make the reflector (7) parallel to the flow plate (2); A rotating rod (72) is fixed to one end of the rotating shaft (71), and when the reflector (7) is in a state parallel to the circulation plate (2), the rotating rod (72) is inclined in a direction close to the circulation plate (2); Two slide rails (8) distributed vertically are fixed on the inner back of the housing (1), a slider (9) is slidably arranged in each of the slide rails (8), and the rotating rod (72) is located at the height of the corresponding slide rail (8), so that the slider (9) can drive the corresponding reflector (7) to rotate when passing through different rotating rods (72).

2. The dedicated flow cell for chromatographic detector according to claim 1, characterized in that: The circulation plate (2) is provided with a liquid inlet pipe (31) and a liquid outlet pipe (41) at the front and rear, respectively; The liquid inlet pipe (31) and the liquid outlet pipe (41) are connected to the liquid inlet (3) and the liquid outlet (4) respectively; The liquid inlet pipe (31) and the liquid outlet pipe (41) are respectively connected to each circulation groove (21), and a solenoid valve (32) is connected between the liquid inlet pipe (31) and each circulation groove (21).

3. The dedicated flow cell for chromatographic detector according to claim 1, characterized in that: Each of the sliders (9) is fixed together via a nut (10), and a screw rod (11) is rotatably connected inside the housing (1), and the screw rod (11) is threadedly connected to the nut (10).

4. The dedicated flow cell for chromatographic detector according to claim 3, characterized in that: A servo motor (12) is provided on one side of the housing (1), and the screw rod (11) is connected to the servo motor (12).

5. The dedicated flow cell for chromatographic detector according to claim 1, characterized in that: It also includes a temperature control system, which includes a heating tube and a temperature sensor arranged inside the housing (1) and is used to adjust and maintain a constant temperature in the circulation pool to meet the needs of temperature-sensitive sample detection.

6. The dedicated flow cell for chromatographic detector according to claim 1, characterized in that: A pressure sensor and a flow meter are provided at the liquid inlet (3) and the liquid outlet (4) for real-time monitoring of the pressure and flow of the mobile phase sample to ensure the stability and accuracy of the detection process. The liquid outlet (4) is connected to a water pump to ensure that the mobile phase in the circulation slot (21) can be discharged from the liquid outlet (4).

7. The dedicated flow cell for chromatographic detector according to claim 2, characterized in that: The solenoid valve (32) is an electrically controlled proportional valve capable of accurately controlling the flow rate of the mobile phase entering each flow slot (21) to achieve more precise sample separation and detection control.

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