Semi-closed negative pressure prosthesis for jaw defect

Abstract

A semi-closed negative pressure restoration for jaw defects comprises a base body and a closed shell, the base body is of a titanium alloy net structure formed through 3D printing, the two ends of the base body can be matched with bone fracture ends in an attached mode, and a negative pressure suction base tube is embedded into the surface of the closed shell inwards. And an outer tube opening of the negative pressure suction base tube is used for being connected with a suction tube of a negative pressure suction device in a sealing manner. Aiming at the situation that the jaw defect degree is that periosteum does not exist, the titanium alloy prosthesis is manufactured through 3D printing, the two ends of the prosthesis are tightly attached to the bone fracture end, the outer surface of the prosthesis is in a closed state, and therefore it is guaranteed that the interior of the prosthesis is in a negative pressure environment and the interior of the prosthesis is of a bone trabecula imitating grid structure under the situation that the periosteum does not exist; a negative pressure suction base tube is arranged at the lower end of the negative pressure suction tube and communicated with a suction tube of a negative pressure suction device, intermittent negative pressure suction (15-30 min / h) is carried out, growth and differentiation of local osteoblasts are promoted, and rapid osteogenic repair in a repair body is promoted.

Description

Technical Field

[0001] The invention belongs to the clinical field of oral and maxillofacial surgery, and specifically relates to a semi-closed negative pressure prosthesis for jaw bone defects. Background Art

[0002] Jaw defects caused by trauma, tumors, infections and other factors not only affect the patient's normal physiological functions, but also cause facial deformities, affect the patient's chewing, swallowing, speech and other functions, and have a serious impact on the patient's mental health. The repair and reconstruction of jaw defects has long been a major challenge facing clinical practice. At present, although methods such as autologous bone transplantation, allogeneic bone transplantation, distraction osteogenesis, and artificial replacement material repair have been used in clinical practice, their application is still greatly restricted due to problems such as complex surgery, limited material sources, and rejection reactions.

[0003] At present, there are studies on negative pressure drainage in clinical treatment. The principle of negative pressure drainage is that negative pressure can accelerate the transformation of highly proliferative epithelium and the bone remodeling of the capsule-bone interface to the cavity, thereby greatly shortening the course of treatment. The negative pressure environment is isolated from the oral bacterial environment, greatly reducing the chance of infection. However, in clinical applications, the repair of jaw defects requires the use of a negative pressure suction device to drain the surgical area. Currently, there is no jaw implant or jaw prosthesis that can be directly connected to negative pressure drainage. Summary of the invention

[0004] In order to solve the above technical problems, the present invention provides a negative pressure drainage restoration for jaw defects.

[0005] The technical solution of the present invention is as follows:

[0006] A semi-closed negative pressure restoration for mandibular defects, characterized in that it comprises a base and a closed shell, wherein the base is a titanium alloy mesh structure formed by 3D printing, and both ends can fit snugly with the broken ends of the bone, and a negative pressure suction base tube is embedded inwardly on the surface of the closed shell, and the outer tube opening of the negative pressure suction base tube is used for sealing and connecting the suction tube of a negative pressure suction device.

[0007] Preferably, the reticular structure is a trabecular bone-like structure.

[0008] Preferably, the closed shell is made of titanium alloy.

[0009] Preferably, the thickness of the closed shell is in the range of 0.3-3 mm, and the diameter of the pipe opening is in the range of 10-20 mm.

[0010] Further preferably, the thickness of the closed shell is 1 mm, and the diameter of the pipe opening is 15 mm.

[0011] Preferably, the negative pressure suction base tube comprises an inner tube and an outer tube, and a gap between the inner tube and the outer tube is used to reserve access to an external negative pressure drainage tube.

[0012] Preferably, the length of the negative pressure suction base tube is 10-30 mm.

[0013] Further preferably, the length of the negative pressure suction base tube is 20 mm.

[0014] Preferably, the negative pressure applied is 125-450 mmHg, and intermittent negative pressure suction is performed for 15-30 minutes / hour.

[0015] The beneficial effects of the present invention are as follows:

[0016] In recent years, additive manufacturing technology has gradually emerged in the field of bone defect repair and has become a popular research and application direction. Compared with traditional subtractive manufacturing technology, additive manufacturing has unique advantages. It can not only produce a restoration that perfectly matches the shape of the mandible, but also accurately control the internal structure of the restoration, thereby preparing a restoration that not only meets the morphological requirements but also promotes bone function repair.

[0017] The present invention utilizes additive technology and 3D printing technology to obtain a restoration matrix that conforms to the shape of the mandibular defect, and designs two restorations that can be used in conjunction with a negative pressure suction device for negative pressure-assisted treatment based on whether periosteum exists.

[0018] Specifically, the present invention is aimed at the situation where the degree of mandibular defect is that the periosteum no longer exists. A titanium alloy restoration is manufactured by 3D printing. The two ends of the restoration are tightly fitted to the broken ends of the bone, and the outer surface is in a closed state. In this way, a negative pressure environment is ensured inside the restoration when the periosteum no longer exists. The interior is a grid structure that imitates trabecular bone, and a negative pressure suction base tube is provided at the lower end to connect to the straw of the negative pressure suction device for intermittent negative pressure suction (15-30 minutes / hour), which promotes the growth and differentiation of local osteoblasts and promotes rapid osteogenic repair in the restoration.

[0019] Experiments have shown that low-intensity intermittent negative pressure in vitro can successfully induce MSCs to grow and differentiate into osteoblasts. In addition, the main reason for the bone resorption of jaw cysts is that the cyst wall tissue secretes cystic fluid, and the increased pressure in the cyst cavity compresses the surrounding bone resorption. Similarly, using a negative pressure forming device to form negative pressure stress in the cyst cavity has a stronger promoting effect on the new bone formation and reconstruction of the restoration-bone interface, which can promote the formation of new bone. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 This is a schematic diagram of the overall structure of the jaw after repair in Example 1;

[0021] Figure 2This is a schematic diagram of the structure of the negative pressure suction base tube and its connection parts in Example 2;

[0022] The numbers in the figure are listed as follows:

[0023] 1-base, 2-enclosed shell, 3-bone end, 4-tube opening, 5-negative pressure suction base tube, 6-gap. DETAILED DESCRIPTION

[0024] In order to better understand the present invention, the present invention is specifically described below by way of examples. It is necessary to point out here that the following examples are only used to further illustrate the present invention and cannot be understood as limiting the scope of protection of the present invention. Some non-essential improvements and adjustments made by professionals and technicians in this field according to the content of the present invention above still belong to the scope of protection of the present invention.

[0025] Example 1

[0026] This embodiment is a case of jaw bone defect and periosteum loss, such as Figure 1 As shown, a negative pressure prosthesis for complete mandibular defect of this embodiment includes a base 1 and a closed shell 2, wherein the base 1 is a trabecular titanium alloy mesh structure imitating bone made by 3D printing, and both ends are tightly fitted and fixed to the bone ends 3, and a titanium alloy negative pressure suction base tube 5 is embedded inwardly on the lower surface of the closed shell 2, and the outer pipe mouth 4 of the negative pressure suction base tube 5 is used for sealing and connecting the suction tube of the negative pressure suction device.

[0027] The thickness of the closed shell is in the range of 0.3-3 mm, the diameter of the tube mouth is 10-20 mm, and the length of the negative pressure suction base tube is 10-30 mm. In this embodiment, the thickness of the closed shell is preferably 1 mm, the diameter of the tube mouth is 15 mm, and the length of the negative pressure suction base tube is 20 mm.

[0028] The pressure value of the negative pressure applied is 125-450 mmHg, which is adjusted according to time and status, and intermittent negative pressure suction is performed for 15-30 minutes / hour.

[0029] Due to the existence of the closed shell 2, it can be ensured that the negative pressure suction base tube is connected to the negative pressure aspirator and after the negative pressure is turned on, the negative pressure inside the repair body continues. At the same time, the negative pressure suction base tube 5 itself can also be used as a drainage tube for discharging tissue fluid.

[0030] According to tests, the bone formation speed is increased by more than 30% compared with the existing technology, and the bone formation amount is increased by more than 50% compared with the existing technology.

[0031] Example 2

[0032] like Figure 2As shown, the difference between this embodiment and embodiment 1 is that the negative pressure suction base tube 5 includes an inner tube and an outer tube, and a gap 6 between the inner tube and the outer tube is used to reserve access to an external negative pressure drainage tube, so as to better discharge tissue fluid.

[0033] The above is only a preferred embodiment of the present invention and is not intended to limit the invention in other forms. Any technician familiar with the profession may use the technical content disclosed above to change or modify it into an equivalent embodiment with equivalent changes. However, any simple modification, equivalent change and modification made to the above embodiment based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still falls within the protection scope of the technical solution of the present invention.

Claims

1. A semi-closed negative pressure prosthesis for jaw defect, characterized in that It includes a base and a closed shell. The base is a titanium alloy mesh structure made by 3D printing, and its two ends can fit closely with the broken ends of the bone. A negative pressure suction base tube is embedded inwardly on the surface of the closed shell. The outer tube opening of the negative pressure suction base tube is used to seal and connect the suction tube of the negative pressure suction device.

2. The restoration according to claim 1, characterized in that The reticular structure is a bone trabecular structure.

3. The restoration according to claim 1, characterized in that The material of the closed shell is titanium alloy.

4. The restoration according to claim 1, characterized in that The thickness of the closed shell is in the range of 0.3-3 mm, and the diameter of the pipe mouth is in the range of 10-20 mm.

5. The restoration according to claim 4, characterized in that The thickness of the closed shell is 1 mm, and the diameter of the pipe opening is 15 mm.

6. The restoration according to claim 1, characterized in that The negative pressure suction base tube comprises an inner tube and an outer tube, and a gap between the inner tube and the outer tube is used to reserve access to an external negative pressure drainage tube.

7. The restoration according to claim 1, characterized in that The length of the negative pressure suction base tube is 10-30 mm.

8. The restoration according to claim 7, characterized in that The length of the negative pressure suction base tube is 20 mm.

9. The restoration according to claim 1, characterized in that The negative pressure applied was 125-450 mmHg, and intermittent negative pressure suction was performed for 15-30 minutes / hour.

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