Experimental animal CT (Computed Tomography) transfer cabin with fixed anesthesia constant temperature

Abstract

The invention discloses an experimental animal CT transfer cabin with a fixed anesthesia constant temperature function. The experimental animal CT transfer cabin is mainly composed of a cabin body shell, a semicircular bottom support, a front spiral sealing cover, a multifunctional adapter block, an experimental animal fixing block, a connecting pipe, an inner side sealing opening, a rear sealing cover and the like. The semicircular bottom support is stably fixed through the inner side sealing opening and the multifunctional switching block, the experimental animal fixing block is arranged on the semicircular bottom support, and all the parts penetrate into the cabin shell in sequence and then are sealed through the front spiral sealing cover and the rear sealing cover. The cabin shell and the semicircular bottom support are made of transparent PC materials, the front spiral sealing cover is sealed through a rubber ring, the multifunctional switching block is provided with a plurality of connecting holes used for transmission of various gases and signal detection, and the experimental animal fixing block is made of polyethylene materials and used for fixing the head of an animal and achieving gas anesthesia operation. The transfer cabin has excellent functions of sealing, anesthesia, constant temperature and the like, can operate a plurality of animals at the same time, is convenient to disassemble and assemble and resistant to high-temperature sterilization, and effectively meets the transfer and related detection requirements of experimental animals.

Description

Technical Field

[0001] The invention belongs to the field of animal transport equipment, and in particular relates to an experimental animal CT transport cabin with fixed anesthesia and constant temperature. Background Art

[0002] In certain scientific research fields, the use of modern medical imaging equipment CT (X-ray computed tomography) to conduct in vivo experimental research on animals is of great significance. It can provide rich information for many aspects of research, such as physiology, pathology, pharmacokinetics, and genetics. CT scans the animal body through X-rays and forms three-dimensional images through computer processing. It plays a key role in the joint imaging research and longitudinal tracking of animals in different modes, which helps to deeply monitor the physiological and biochemical processes of animals and evaluate the effects of different treatments on the course of the disease. However, the experimental process requires not only precise fixation and positioning of experimental animals and their related conjoined medical equipment, but also frequent movement and repositioning between different inspection equipment, which makes the experimental operation complicated and easily interferes with the experimental results. The current technical means are insufficient in meeting the various needs of experimental animal transportation, such as the difficulty in ensuring that the animals are always in a stable and suitable environment during transportation, the lack of effective anesthesia and temperature control means, and the difficulty in achieving convenient connection and sealed transportation with the detection equipment. Therefore, there is an urgent need for an experimental animal transportation cabin that can overcome these defects to improve the efficiency and accuracy of the experiment, to ensure the welfare of experimental animals and the reliability of experimental results. Summary of the invention

[0003] The purpose of the present invention is to provide an experimental animal CT transport cabin with fixed anesthesia and constant temperature, aiming to solve the problems existing in the above-mentioned background technology. To achieve the above-mentioned purpose, the technical solution adopted by the present invention is:

[0004] The invention discloses an experimental animal CT transport cabin with fixed anesthesia and constant temperature, comprising a cabin shell, a semicircular bottom support, a front spiral sealing cover, a multifunctional adapter block, an experimental animal fixing block, a connecting pipe, an inner sealing cover and a rear sealing cover. The front and rear sides of the cabin shell are respectively provided with the front spiral sealing cover and the rear sealing cover, the interior of the cabin shell is provided with a semicircular bottom support, the inner sides of the front spiral sealing cover and the rear sealing cover are respectively provided with the multifunctional adapter block and the inner sealing cover, the semicircular bottom support is fixed by the multifunctional adapter block and the inner sealing cover, the multifunctional adapter block and the inner sealing cover are used to prevent the semicircular bottom support from shifting, one end of the experimental animal fixing block is connected to the semicircular bottom support, the other end of the experimental animal fixing block is connected to the multifunctional adapter block by a connecting pipe, the experimental animal fixing block is used to fix the head of the experimental animal, and the experimental animal fixing block can pass in and out animal anesthetic gas by the connecting pipe and the multifunctional adapter block.

[0005] Preferably, the cabin shell is made of transparent PC material, which has excellent electrical insulation, dimensional stability and chemical corrosion resistance, and has high strength, heat resistance and cold resistance.

[0006] Preferably, the semicircular bottom bracket is a double-layer structure and is made of transparent PC material. The semicircular bottom bracket requires air circulation and adopts a double-layer structure.

[0007] Preferably, a rubber ring is provided inside the spiral sealing cover for sealing.

[0008] Preferably, a plurality of connection holes are provided on the outer side of the multifunctional adapter block, including a hot air inlet hole, an electrocardiogram signal detection hole, a body temperature detection hole, a respiratory signal detection hole, an anesthetic gas inlet hole and an anesthetic gas exhaust hole, and the connection block can be increased as needed.

[0009] Preferably, the material of the experimental animal fixing block is polyethylene.

[0010] Beneficial effects of the present invention:

[0011] Excellent sealing performance: Under a pressure difference of ±250Pa, the hourly leakage rate does not exceed 0.25%, effectively isolating the external environment, ensuring the stability of the cabin environment during transportation, greatly reducing the interference of external factors on experimental animals and experimental results, and providing precise environmental conditions for the experiment.

[0012] Efficient anesthesia function: The unique gas anesthesia function design can accurately anesthetize experimental animals according to experimental requirements during transportation. Anesthetic gas is discharged through a special air inlet, and can be safely discharged from the exhaust hole after the animal is anesthetized, which is convenient for flexible control of the animal's state, significantly improving the safety and operability of the experiment, and reducing the risk of animals caused by improper anesthesia operation.

[0013] Precise temperature control: hot air of suitable temperature can be sent into the cabin through the hot air inlet, effectively protecting the temperature of experimental animals. It can accurately adjust the temperature in the cabin according to the physiological characteristics of experimental animals and changes in the external environment, maintain the normal physiological state of animals, thereby increasing experimental stability, ensuring the accuracy and reliability of experimental data, and avoiding the impact of temperature fluctuations on experimental results.

[0014] Ability to operate multiple animals simultaneously: The ingenious structural design allows for at least two experimental animals to be operated at the same time, greatly improving experimental efficiency. More experimental data can be obtained during one transport and testing process, which helps to complete experimental research comprehensively and quickly, saving time and resources.

[0015] Convenient disassembly and assembly: It has a quick disassembly and assembly function, which is convenient for maintenance, cleaning and transportation of the equipment. The airtightness in the transfer cabin is not affected during the disassembly and assembly process, ensuring the reusability and stability of the equipment, reducing equipment maintenance costs, and increasing equipment life. At the same time, it ensures that a good sealing effect can be achieved every time it is used.

[0016] High temperature sterilization resistant material: The material used in the transfer cabin can withstand high temperature sterilization treatment, which can effectively kill bacteria, viruses and other microorganisms and prevent cross infection. This feature meets the strict hygiene requirements of the experiment, protects the health of experimental animals, ensures that the experimental results are not affected by microbial contamination, and improves the accuracy and scientificity of the experimental results. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 An overall schematic diagram provided for an embodiment of the present invention;

[0018] Figure 2 A schematic diagram of an overall explosion structure provided by an embodiment of the present invention;

[0019] Figure 3 A schematic diagram of the structure of a multifunctional adapter block provided in an embodiment of the present invention;

[0020] Figure 4 Schematic diagram of the structure of a multifunctional adapter block according to an embodiment of the present invention.

[0021] Among them, the reference numerals in the figure are:

[0022] 1. Cabin shell; 2. Semicircular bottom support; 3. Front spiral sealing cover; 4. Multifunctional adapter block; 5. Experimental animal fixing block; 6. Connecting pipe; 7. Inner seal; 8. Rear sealing cover; 9. Connecting hole. DETAILED DESCRIPTION

[0023] In order to facilitate the understanding of the present invention, the present invention will be described more fully below with reference to the relevant drawings. The preferred embodiments of the present invention are given in the drawings. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thoroughly understood.

[0024] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may also be a centered element. When an element is considered to be "connected" to another element, it may be directly connected to the other element or there may be a centered element at the same time. On the contrary, when an element is referred to as being "directly on" another element, there is no intermediate element. The terms "vertical", "horizontal", "left", "right" and similar expressions used herein are for illustrative purposes only and are not intended to be the only implementation method. The terms "upper end", "lower end", "left side", "right side", "front end", "rear end" and similar expressions used herein are positional relationships with reference to the accompanying drawings.

[0025] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art of the present invention. The terms used herein in the specification of the present invention are only for the purpose of describing specific embodiments and are not intended to limit the present invention. The term "and / or" used herein includes any and all combinations of one or more related listed items.

[0026] The technical solution of this patent is further described in detail below in conjunction with specific implementation methods.

[0027] like Figures 1 to 4 As shown, an embodiment of the present invention provides an experimental animal CT transport cabin with fixed anesthesia and constant temperature, including a cabin shell 1, a semicircular bottom support 2, a front spiral sealing cover 3, a multifunctional adapter block 4, an experimental animal fixing block 5, a connecting pipe 6, an inner seal 7 and a rear sealing cover 8. The front and rear sides of the cabin shell 1 are respectively provided with a front spiral sealing cover 3 and a rear sealing cover 8, the interior of the cabin shell 1 is provided with a semicircular bottom support 2, the inner sides of the front spiral sealing cover 3 and the rear sealing cover 8 are respectively provided with a multifunctional adapter block 4 and an inner seal 7 cover, the semicircular bottom support 2 is fixed by the multifunctional adapter block 4 and the inner seal 7 cover, the multifunctional adapter block 4 and the inner seal 7 cover are used to prevent the semicircular bottom support 2 from shifting, one end of the experimental animal fixing block 5 is connected to the semicircular bottom support 2, and the other end of the experimental animal fixing block 5 is connected to the multifunctional adapter block 4 through a connecting pipe 6, the experimental animal fixing block 5 is used to fix the head of the experimental animal, and the experimental animal fixing block 5 can pass and discharge animal anesthetic gas through the connecting pipe 6 and the multifunctional adapter block 4.

[0028] In the embodiment, the cabin shell 1 is made of transparent PC material, which has excellent electrical insulation, dimensional stability and chemical corrosion resistance, and has high strength, heat resistance and cold resistance.

[0029] In the embodiment, the semicircular base 2 is a double-layer structure and is made of transparent PC material. The semicircular base 2 needs to circulate gas and adopts a double-layer structure.

[0030] In the embodiment, a rubber ring is provided inside the spiral sealing cover for sealing.

[0031] In the embodiment, a plurality of connection holes 9 are provided on the outer side of the multifunctional adapter block 4, and the connection holes 9 include a hot air inlet hole, an electrocardiogram signal detection hole, a body temperature detection hole, a respiratory signal detection hole, an anesthetic gas inlet hole and an anesthetic gas exhaust hole. The connection block can be increased as needed.

[0032] In the embodiment, the material of the experimental animal fixing block 5 is polyethylene.

[0033] How it works

[0034] Structural composition and fixing principle

[0035] The semicircular bottom bracket 2 is the main load-bearing part of the experimental animals, and its stability is of vital importance. The inner sealing cover 7 and the multifunctional adapter block 4 fix the semicircular bottom bracket 2 from both sides, and the inner sealing cover 7 fits tightly against the edge of the semicircular bottom bracket 2. The multifunctional adapter block 4 locks the semicircular bottom bracket 2 firmly at a predetermined position in the cabin shell 1 through the cooperation with the specific connection structure (such as the slot, protrusion, etc.) of the semicircular bottom bracket 2 and the front spiral sealing cover 3, providing a stable support plane for the experimental animals to prevent them from being displaced due to shaking during transportation.

[0036] One end of the experimental animal fixing block 5 is tightly connected to the semicircular base 2 by welding, clamping or bolting, ensuring that the fixing block will not move relative to the semicircular base 2. The other end is connected to the multifunctional adapter block 4 through a connecting tube 6, which can be a flexible or rigid pipe to ensure that the natural posture of the animal's head is not affected during the connection. The experimental animal fixing block 5 is designed with corresponding grooves, straps or clamps according to the shape of the animal's head, which can accurately fix the head of the experimental animal, limit its head movement, avoid the shaking of the animal's head during transportation and testing to interfere with the experiment, and ensure that the basic physiological functions of the animal, such as unobstructed breathing, are not affected.

[0037] The cabin shell 1 serves as the external protection structure of the entire transfer cabin. The front spiral sealing cover 3 and the rear sealing cover 8 are respectively arranged on the front and rear sides thereof, which are tightly screwed together through a threaded structure. The multifunctional adapter block 4 and the inner sealing cover 7 on the inner side of the front spiral sealing cover 3 and the rear sealing cover 8 not only play the role of fixing the semicircular base 2, but also participate in the sealing process. The rubber ring inside the front spiral sealing cover 3 is squeezed during the tightening process, filling the tiny gap between the sealing cover and the cabin shell 1, forming a reliable sealing barrier, preventing gas leakage in the cabin and the entry of external pollutants, thereby maintaining the stability of the cabin environment, ensuring that the experimental animals are in a relatively closed and stable space, and creating good conditions for the smooth progress of the experiment.

[0038] Gas anesthesia and circulation principles

[0039] When anesthesia is required for the experimental animals, the external anesthetic gas supply device (such as an anesthesia machine) is connected to the anesthetic gas inlet on the multifunctional adapter block 4 through a pipeline. Anesthetic gas (such as isoflurane, sevoflurane and other commonly used inhalation anesthetics) enters the connecting tube 6 through the inlet under a certain pressure. The connecting tube 6 is smooth inside and has a suitable diameter, which enables the anesthetic gas to flow smoothly to the experimental animal fixing block 5. A gas dispersion channel or a microporous structure is provided inside the experimental animal fixing block 5, so that the incoming anesthetic gas is evenly distributed around the animal's mouth and nose, and the animal inhales the anesthetic gas into the body through natural breathing, thereby achieving safe and effective anesthesia induction and maintenance.

[0040] During the anesthesia process, the waste gas containing anesthetic gas exhaled by the animal enters the connecting pipe 6 through the gas reflux channel in the experimental animal fixing block 5, and then is discharged outside the cabin through the anesthetic gas discharge hole on the multifunctional adapter block 4. The discharge hole is connected with a waste gas treatment device (such as an activated carbon adsorption device, a gas purification filter, etc.) to ensure that the discharged waste gas does not pollute the surrounding environment. During the entire anesthetic gas circulation process, the flow rate, concentration and ventilation time of the anesthetic gas can be accurately controlled by the flow regulating valve, concentration monitor and other components on the anesthetic gas supply device according to the type of experimental animal (such as mice, rats, rabbits and other animals have different tolerance and demand for anesthetics), body weight (the amount of anesthetics is generally calculated according to the body weight ratio) and experimental requirements (such as different requirements for anesthesia depth, the length of surgical operation time affects the anesthesia maintenance dose, etc.), to ensure that the anesthetic effect is stable and reliable, so that the animal can be in a suitable anesthesia state, which is convenient for experimental operation, and can avoid damage to the animal caused by too deep or too shallow anesthesia, so as to ensure the safety of animal life and the accuracy of experimental data.

[0041] Temperature control principle

[0042] The hot air supply device (such as a constant temperature hot air blower, a temperature-controllable air heater, etc.) is connected to the hot air inlet of the multifunctional adapter block 4 through a high temperature resistant and well-sealed pipe. According to the physiological characteristics of the experimental animals (different types of animals have different temperature regulation ranges and suitable temperatures, for example, the suitable temperature for mice is around 20-26°C, and that for rats is around 20-24°C, etc.) and the external environment temperature (for example, more heat needs to be provided in a cold environment, and appropriate cooling or maintaining a lower heating power may be required in a hot environment), the output temperature and air volume of the hot air supply device are pre-set.

[0043] When the temperature in the cabin needs to be adjusted, the hot air supply device will send the heated and air volume adjusted air into the cabin through the hot air inlet. The cabin space is reasonably designed so that the air can be evenly distributed and circulated in the cabin, so that the temperature in the entire cabin quickly reaches the set value and remains stable. The cabin temperature is monitored in real time by a temperature sensor installed in the cabin (which can be integrated with the temperature detection hole on the multifunctional adapter block 4 or set separately) and fed back to the temperature control system of the hot air supply device. The temperature control system automatically adjusts the heating power or fan speed of the hot air supply device according to the feedback signal, thereby achieving precise control of the cabin temperature. In this way, the experimental animals are always in a suitable temperature environment during the transportation and detection process, avoiding stress reactions caused by animals due to excessively high or low temperatures (such as excessive body temperature may cause metabolic disorders and rapid breathing in animals, and low body temperature may cause frostbite and decreased physiological functions in animals), maintaining the normal physiological state of animals, ensuring that the experimental data is not interfered by temperature factors, and ensuring the accuracy and reliability of the experimental results.

[0044] Signal detection and transmission principle

[0045] The ECG signal detection hole and the body temperature detection hole on the multifunctional adapter block 4 are respectively connected to the specific ports of the external CT device (or other related monitoring equipment) through dedicated cables with good shielding performance. One end of the ECG signal detection cable is connected to the ECG electrode sheet (the electrode sheet is attached to the appropriate body surface position of the experimental animal, such as the limbs and chest, etc., to accurately obtain the ECG signal), and the other end is connected to the ECG signal acquisition module of the external CT device through the ECG signal detection hole on the adapter block. The body temperature detection cable is connected to the temperature probe (the probe can be placed on the animal's body surface or in a suitable position in the body, such as the rectum, armpit, etc., to accurately measure the body temperature), and the temperature signal is transmitted to the body temperature monitoring unit of the CT device through the body temperature detection hole.

[0046] When the experimental animals are in the cabin, their ECG signals and body temperature data are transmitted to the CT device in real time and continuously through the corresponding detection holes. The data processing system inside the CT device filters, amplifies, analyzes and processes the received ECG signals, converts them into intuitive ECG waveforms and displays them on the device screen, while monitoring and recording the body temperature data in real time. During the entire detection process, whether it is during the transportation process or during the CT scanning test, there is no need to open the transfer cabin. The transfer cabin and the CT device can be conveniently connected and separated by simply plugging and unplugging the connection plug. This design ensures the continuity of the detection process, avoids external interference (such as temperature changes, bacterial contamination, etc.) that may be introduced by opening the cabin, and ensures that the sealing performance of the transfer cabin is not affected, maintaining a stable environment in the cabin. Through real-time monitoring of the animal's vital signs, researchers can timely understand the changes in the animal's physiological state, and can quickly take corresponding measures (such as adjusting the depth of anesthesia, temperature, etc.) when abnormal conditions are found during the experiment, providing comprehensive and accurate data support for the experiment and ensuring the safety and smooth progress of the experiment.

[0047] The above implementation modes are only used to illustrate the present invention, but not to limit the present invention. Ordinary technicians in the relevant technical field can make various changes and modifications without departing from the spirit and scope of the present invention. Therefore, all equivalent technical solutions also belong to the scope of the present invention. The patent protection scope of the present invention should be defined by the claims.

Claims

1. A laboratory animal CT transport cabin with fixed anesthesia and constant temperature, characterized by: It includes a cabin shell, a semicircular bottom support, a front spiral sealing cover, a multifunctional adapter block, an experimental animal fixing block, a connecting pipe, an inner sealing and a rear sealing cover. The front and rear sides of the cabin shell are respectively provided with the front spiral sealing cover and the rear sealing cover. The interior of the cabin shell is provided with the semicircular bottom support. The inner sides of the front spiral sealing cover and the rear sealing cover are respectively provided with the multifunctional adapter block and the inner sealing cover. The semicircular bottom support is fixed by the multifunctional adapter block and the inner sealing cover. The multifunctional adapter block and the inner sealing cover are used to prevent the semicircular bottom support from shifting. One end of the experimental animal fixing block is connected to the semicircular bottom support, and the other end of the experimental animal fixing block is connected to the multifunctional adapter block through the connecting pipe. The experimental animal fixing block is used to fix the head of the experimental animal. The experimental animal fixing block can pass and discharge animal anesthetic gas through the connecting pipe and the multifunctional adapter block.

2. The experimental animal CT transport cabin with fixed anesthesia and constant temperature according to claim 1, characterized in that: The cabin shell is made of transparent PC material.

3. The experimental animal CT transport cabin with fixed anesthesia and constant temperature according to claim 2, characterized in that: The semicircular base has a double-layer structure and is made of transparent PC material.

4. The experimental animal CT transport cabin with fixed anesthesia and constant temperature according to claim 3, characterized in that: The spiral sealing cover is sealed with a rubber ring.

5. The experimental animal CT transport cabin with fixed anesthesia and constant temperature according to claim 4, characterized in that: A plurality of connection holes are arranged on the outer side of the multifunctional adapter block, and the connection holes include a hot air inlet hole, an electrocardiogram signal detection hole, a body temperature detection hole, a respiratory signal detection hole, an anesthetic gas inlet hole and an anesthetic gas exhaust hole.

6. The experimental animal CT transport cabin with fixed anesthesia and constant temperature according to claim 5, characterized in that: The material of the experimental animal fixing block is polyethylene.

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