Toothpaste for freshening breath and preparation method thereof

Abstract

The invention relates to toothpaste for freshening breath and a preparation method thereof, the toothpaste is prepared from the following raw materials: a composition for freshening breath, a foaming agent, a friction agent, a thickening agent and water, and the composition for freshening breath is prepared from a honeysuckle flower extract, a field mint extract and a yeast fermentation product extract. The toothpaste disclosed by the invention has an effect of freshening breath, and the honeysuckle flower extract, the field mint extract and the yeast fermentation product extract have a certain synergistic effect on the effects.

Description

Technical Field

[0001] The invention belongs to the technical field of daily necessities and relates to a toothpaste for refreshing breath and a preparation method thereof. Background Art

[0002] Bad breath is a common problem that affects people's quality of life and social confidence. Oral bacteria, such as Porphyromonas gingivalis and Fusobacterium nucleatum, decompose proteins, peptides, and amino acids in food residues, and produce a series of volatile sulfides during metabolism, including hydrogen sulfide, methyl mercaptan, and dimethyl sulfide. These volatile sulfides have a strong odor and are one of the main sources of bad breath.

[0003] In addition, oral diseases can significantly increase the problem of bad breath. For example, the cavities of patients with caries often accumulate a large amount of food residues and bacteria, and the odor produced by bacterial fermentation will be emitted through the cavities; patients with periodontitis have a significant increase in the number of bacteria in the mouth due to gingival inflammation, periodontal pocket formation, and alveolar bone absorption, and the tissue decomposition products under the inflammatory state will also produce odor; in addition, oral mucosal diseases, such as oral ulcers, oral candidiasis, etc., necrotic tissue and bacterial growth in the lesion site can also cause bad breath.

[0004] From the perspective of quality of life, fresh breath can make people feel more comfortable and confident. Whether in daily work, study or leisure, the absence of bad breath can make people more focused on the task at hand, improve work and study efficiency, and also improve the individual's overall mental state and life satisfaction. This strong demand for fresh breath in terms of social interaction and quality of life has prompted the oral care market to continuously seek more effective solutions to meet consumers' desire for fresh oral cavity.

[0005] Therefore, it is urgent to develop a toothpaste product that can provide lasting fresh breath and is safe and non-irritating. Summary of the invention

[0006] In view of the deficiencies in the prior art, the object of the present invention is to provide a breath-freshening toothpaste and a preparation method thereof.

[0007] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0008] In a first aspect, the present invention provides a breath-freshening toothpaste, wherein raw materials for preparing the toothpaste include a breath-freshening composition, a foaming agent, an abrasive, a thickener and water, wherein the breath-freshening composition includes honeysuckle extract, field mint extract and yeast fermentation product extract.

[0009] The toothpaste of the present invention has the effect of refreshing breath, and the honeysuckle flower extract, the field mint extract and the yeast fermentation product extract have a certain synergistic effect on the above effect.

[0010] Preferably, the raw materials for preparing the toothpaste include, by mass, 1-3 parts of a breath freshening composition, 5-10 parts of a foaming agent, 18-24 parts of an abrasive, 0.5-1.5 parts of a thickener and 20-30 parts of water.

[0011] The mass fraction of the composition can be selected from 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, 2.2 parts, 2.4 parts, 2.6 parts, 2.8 parts, 3 parts, etc., the mass fraction of the foaming agent can be selected from 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, etc., and the mass fraction of the friction agent can be selected from 18 parts, 18.5 parts, 19 parts, 19.5 parts, 20 parts, 20.5 parts, 2 1 part, 21.5 parts, 22 parts, 22.5 parts, 23 parts, 23.5 parts, 24 parts, etc., the mass parts of the thickener can be selected from 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 parts, 1.1 parts, 1.2 parts, 1.3 parts, 1.4 parts, 1.5 parts, etc., the mass parts of water can be selected from 20 parts, 22 parts, 24 parts, 26 parts, 28 parts, 30 parts, etc., and other specific point values ​​within the above numerical range can be selected, so they will not be described one by one here.

[0012] Preferably, the breath-freshening composition comprises, by mass, 1-3 parts of honeysuckle extract, 1-3 parts of field mint extract, and 0.1-1 part of yeast fermentation product extract.

[0013] The mass fractions of honeysuckle extract can be selected from 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, 2.2 parts, 2.4 parts, 2.6 parts, 2.8 parts, 3 parts, etc.; the mass fractions of field mint extract can be selected from 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, 2.2 parts, 2.4 parts, 2.6 parts, 2.8 parts, 3 parts, etc.; the mass fractions of yeast fermentation product extract can be selected from 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, etc. Other specific point values ​​within the above numerical range can be selected, and they will not be elaborated here one by one.

[0014] Preferably, the foaming agent includes any one of cocamidopropyl betaine, sodium lauryl sulfate, and polyethylene glycol-32, or a combination of at least two of them.

[0015] Preferably, the thickener comprises xanthan gum and / or hydroxyethyl cellulose.

[0016] Preferably, the abrasive comprises hydrated silica.

[0017] Preferably, the raw materials for preparing the toothpaste further include any one of a moisturizer, a fragrance, a preservative, an anti-caries agent, a pH adjuster or a taste improver, or a combination of at least two thereof.

[0018] Preferably, the raw materials for preparing the toothpaste further include, by mass, any one or a combination of at least two of 32-40 parts of moisturizer, 0.1-0.5 parts of fragrance, 0.1-0.8 parts of preservative, 0.1-0.5 parts of anti-caries agent, 0.1-0.5 parts of pH adjuster and 0.1-1 parts of taste improver.

[0019] The mass fraction of moisturizer can be selected as 32 parts, 33 parts, 34 parts, 35 parts, 36 parts, 37 parts, 38 parts, 39 parts, 40 parts, etc., the mass fraction of fragrance can be selected as 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, 0.35 parts, 0.4 parts, 0.45 parts, 0.5 parts, etc., the mass fraction of preservative can be selected as 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, etc., to prevent caries The mass fraction of the agent can be selected from 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, etc., the mass fraction of the pH adjuster can be selected from 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, etc., the mass fraction of the taste improver can be selected from 0.1 parts, 0.2 parts, 0.3 parts, 0.4 parts, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 parts, etc., and other specific point values ​​within the above numerical range can be selected, so they will not be described one by one here.

[0020] Preferably, the moisturizing agent includes any one of glycerin, sorbitol, tranexamic acid, bisabolol, ginger root extract, persimmon fruit extract, or a combination of at least two thereof.

[0021] Preferably, the fragrance comprises essence.

[0022] Preferably, the preservative comprises methylpropanediol and / or o-cymene-5-ol.

[0023] Preferably, the anticaries agent comprises sodium fluoride.

[0024] Preferably, the pH adjuster comprises sodium hydroxide.

[0025] Preferably, the taste improver comprises galactose.

[0026] In a second aspect, the present invention provides a method for preparing the breath-freshening toothpaste according to the first aspect, the preparation method comprising: physically mixing the preparation raw materials and defoaming to obtain the toothpaste.

[0027] Compared with the prior art, the present invention has the following beneficial effects:

[0028] The toothpaste of the present invention has the effect of refreshing breath, and the honeysuckle flower extract, the field mint extract and the yeast fermentation product extract have a certain synergistic effect on the above effect. DETAILED DESCRIPTION

[0029] In order to further explain the technical means and effects adopted by the present invention, the technical solution of the present invention is further described below in conjunction with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0030] The sources of the functional ingredients contained in the products involved in the following embodiments and comparative examples are as follows (only the functional ingredients are reflected, and the necessary auxiliary ingredients contained in other commercially available raw materials are not repeated):

[0031] Honeysuckle flower extract is a product purchased from RILIS CO., LTD. under the trade name of Honeysuckle flower extract;

[0032] Field mint extract is a product purchased from Guangzhou Tianci High-tech Materials Co., Ltd. under the trade name of mint extract;

[0033] Yeast fermentation product extract was purchased from BASF (China) Co., Ltd. under the trade name BioToLife;

[0034] Cocamidopropyl betaine was purchased from Guangzhou Tianci High-tech Materials Co., Ltd. under the trade name TC-CAB35GL;

[0035] Polyethylene glycol-32 is a product purchased from Dow Chemical (Shanghai) Co., Ltd. under the trade name CARBOWAX SENTRY Polyethylene Glycol 1450NF Flake (Inhibited);

[0036] Xanthan gum was purchased from Ordos Zhongxuan Biochemical Co., Ltd. under the trade name of xanthan gum RH;

[0037] Hydroxyethylcellulose was purchased from Ashland LLC under the trade name of natrosol 250mx pchydroxyethylcellulose;

[0038] Ginger root extract was purchased from Symsin Flavors & Fragrances (Nantong) Co., Ltd. under the trade name SymRelief 100;

[0039] Persimmon fruit extract was purchased from RILIS CO., LTD. under the trade name PANCILBA-200G-1;

[0040] The fragrance was purchased from Givaudan Fragrances & Fragrances (Shanghai) Co., Ltd. with the trade name of Pure Iris Upgraded Version AAN45287 / 01.

[0041] Example 1

[0042] The present embodiment provides a breath-freshening composition, wherein the breath-freshening and whitening composition comprises, by weight, 2 parts of honeysuckle extract, 2 parts of field mint extract, and 0.5 parts of yeast fermentation product extract.

[0043] The preparation method thereof is as follows: physically mixing the preparation raw materials to obtain the product.

[0044] Example 2

[0045] The present embodiment provides a breath-freshening composition, wherein the breath-freshening and whitening composition comprises, by weight, 1 part of honeysuckle extract, 1 part of field mint extract, and 1 part of yeast fermentation product extract.

[0046] The preparation method is similar to that of Example 1.

[0047] Example 3

[0048] The present embodiment provides a breath-freshening composition, wherein the breath-freshening and whitening composition comprises, by weight, 3 parts of honeysuckle extract, 3 parts of field mint extract, and 0.1 parts of yeast fermentation product extract.

[0049] The preparation method is similar to that of Example 1.

[0050] Comparative Example 1

[0051] This comparative example provides a breath-freshening composition, which is different from Example 1 only in that the honeysuckle flower extract is not contained, and the reduced mass thereof is proportionally distributed to the masses of the field mint extract and the yeast fermentation product extract.

[0052] The preparation method is similar to that of Example 1.

[0053] Comparative Example 2

[0054] This comparative example provides a breath-freshening composition, which is different from Example 1 only in that it does not contain the field mint extract, and the reduced mass thereof is proportionally distributed to the masses of the honeysuckle flower extract and the yeast fermentation product extract.

[0055] The preparation method is similar to that of Example 1.

[0056] Comparative Example 3

[0057] This comparative example provides a breath-freshening composition, which is different from Example 1 only in that it does not contain the yeast fermentation product extract, and the reduced mass thereof is proportionally distributed to the masses of the honeysuckle flower extract and the field mint extract.

[0058] The preparation method is similar to that of Example 1.

[0059] Application Example 1

[0060] This application example provides a toothpaste for freshening breath. The raw materials for preparing the toothpaste include, by mass, 2 parts of the composition of Example 1, 2 parts of cocamidopropyl betaine, 2 parts of sodium lauryl sulfate, 3 parts of polyethylene glycol-32, 0.5 parts of xanthan gum, 0.5 parts of hydroxyethyl cellulose, 21 parts of hydrated silica, 5 parts of glycerin, 30 parts of sorbitol, 0.1 parts of tranexamic acid, 0.1 parts of bisabolol, 0.1 parts of ginger root extract, 0.1 parts of persimmon fruit extract, 0.2 parts of flavor, 0.2 parts of methylpropanediol, 0.2 parts of o-cymene-5-ol, 0.2 parts of sodium fluoride, 0.2 parts of sodium hydroxide, 0.5 parts of trichlorogalactose and 25 parts of water.

[0061] The preparation method comprises the following steps: mixing the raw materials at 900 rpm and defoaming to obtain the product.

[0062] Application Example 2

[0063] This application example provides a toothpaste for freshening breath. The raw materials for preparing the toothpaste include, by mass, 1 part of the composition of Example 2, 3 parts of cocamidopropyl betaine, 3 parts of sodium lauryl sulfate, 3 parts of polyethylene glycol-32, 0.3 parts of xanthan gum, 0.3 parts of hydroxyethyl cellulose, 18 parts of hydrated silica, 5 parts of glycerol, 27 parts of sorbitol, 0.1 parts of tranexamic acid, 0.1 parts of bisabolol, 0.1 parts of ginger root extract, 0.1 parts of persimmon fruit extract, 0.1 parts of flavor, 0.1 parts of methylpropanediol, 0.1 parts of o-cymene-5-ol, 0.5 parts of sodium fluoride, 0.5 parts of sodium hydroxide, 1 part of trichlorogalactose and 20 parts of water.

[0064] The preparation method comprises the following steps: mixing the raw materials at 1100 rpm and defoaming to obtain the product.

[0065] Application Example 3

[0066] This application example provides a toothpaste for freshening breath. The raw materials for preparing the toothpaste include, by mass, 3 parts of the composition of Example 3, 2 parts of cocamidopropyl betaine, 2 parts of sodium lauryl sulfate, 1 part of polyethylene glycol-32, 0.7 parts of xanthan gum, 0.7 parts of hydroxyethyl cellulose, 24 parts of hydrated silica, 5 parts of glycerol, 34 parts of sorbitol, 0.1 parts of tranexamic acid, 0.1 parts of bisabolol, 0.1 parts of ginger root extract, 0.1 parts of persimmon fruit extract, 0.5 parts of flavor, 0.3 parts of methylpropanediol, 0.3 parts of o-cymene-5-ol, 0.1 parts of sodium fluoride, 0.1 parts of sodium hydroxide, 0.1 parts of trichlorogalactose and 30 parts of water.

[0067] The preparation method comprises the following steps: mixing the raw materials at 30 DEG C and 700 rpm, and defoaming to obtain the product.

[0068] Comparative Application Examples 1-3

[0069] This comparative application example provides three kinds of breath-freshening toothpastes, which differ from application example 1 only in that the composition of example 1 is replaced by the compositions of comparative examples 1-3 in equal amounts, and other ingredients and contents remain unchanged.

[0070] The preparation method refers to Application Example 1.

[0071] Test Example 1

[0072] This test uses a consumer questionnaire to collect healthy subjects' comments on the product 120 minutes after a single use of the test product under normal circumstances, and evaluates how long the product maintains a cooling feeling.

[0073] Test products: Application examples 1-3, comparative application examples 1-3.

[0074] Directions: Use 1g of toothpaste to brush your teeth for three minutes, 10 people per group.

[0075] Subject inclusion criteria:

[0076] (1) Healthy men and women, aged 18-60 years;

[0077] (2) Those who use toothpaste-based cleaning products;

[0078] (3) Be able to cooperate well with the experimenters and maintain a regular life during the study;

[0079] (4) Be able to read and understand all the contents of the informed consent form and voluntarily sign the informed consent form;

[0080] (5) Agree not to use any cosmetics, drugs or health products that may affect the results during the trial;

[0081] (6) Other corresponding inclusion criteria.

[0082] Exclusion criteria:

[0083] (1) Those with skin diseases that may affect the judgment of the test results;

[0084] (2) Those with highly allergic constitution;

[0085] (3) Those with a history of allergic reactions to cosmetics;

[0086] (4) Women who are pregnant, breastfeeding, or planning to become pregnant during the trial;

[0087] (5) Those with severe heart, liver, or kidney damage and severe immunodeficiency;

[0088] (6) People with mental illness, severe endocrine diseases, or those taking oral contraceptives;

[0089] (7) Those with significant nutritional disorders;

[0090] (8) Those who have participated in drug clinical trials or other trials within 30 days, or those who have systematically used drugs that may affect the trial results within the past week;

[0091] (9) Those who have taken oral or external cosmetic products that may affect the test results within 2 weeks;

[0092] (10) Those who are unable to cooperate with the experiment;

[0093] (11) Those who are considered by the researchers to be unsuitable for participation in this study;

[0094] (12) Other corresponding exclusion criteria.

[0095] Exit criteria:

[0096] Patients may withdraw from the clinical study due to complications, adverse events or other reasons during the study.

[0097] Subject self-assessment:

[0098] (1) Oral status survey:

[0099] Test method: After using the sample, ask every 5 minutes (within 120 minutes) whether the mouth feels cool. The results are shown in Table 1.

[0100] Table 1

[0101] Group Cooling duration (min) Application Example 1 89 Application Example 2 83 Application Example 3 78 Comparative application example 1 42 Comparative Application Example 2 37 Comparative Application Example 3 35

[0102] It can be seen from the data in Table 1 that the toothpaste prepared by the present invention has a good cooling effect, the cooling effect is maintained for a long time, and the honeysuckle extract, field mint extract and yeast fermentation product extract have a certain synergistic effect on the above effect.

[0103] (2) Product efficacy research

[0104] Test method:

[0105] The subjects' scores were recorded 5 minutes after using the sample, using a 5-point system, where 1 was strongly disagree, 2 was disagree, 3 was indifferent between agreement or disagreement, 4 was agree, and 5 was strongly agree.

[0106] The results are shown in Table 2, with one decimal place retained.

[0107] Table 2

[0108]

[0109]

[0110] It can be seen from the data in Table 2 that the toothpaste prepared by the present invention has a good effect of alleviating bad breath, strong cleaning ability, mildness and non-irritation, and a high degree of comfort. The honeysuckle extract, field mint extract and yeast fermentation product extract have a certain synergistic effect on the above effects.

[0111] Test Example 2

[0112] Fresh breath effect test

[0113] Test principle: The main components of bad breath gas are volatile sulfides, including methyl mercaptan, hydrogen sulfide and dimethyl sulfide, which are produced by various reasons, about 90% of which come from the mouth. This experiment simulates the use of oral care products in vitro, cultivates the production of volatile sulfides in the oral saliva secretions of volunteers, and measures methyl mercaptan to evaluate the breath freshening effect.

[0114] Test method:

[0115] (1) Cultivating hydroxyapatite sheets overnight to form acquired biofilms;

[0116] (2) Control group: soaked in deionized water for 2 min, taken out and placed in a headspace bottle;

[0117] Sample group: soaked in toothpaste slurry for 2 minutes, taken out and placed in a headspace bottle;

[0118] Preparation method of toothpaste slurry: Mix the sample with water in a mass ratio of 1:3;

[0119] (3) Mix saliva with thioglycollate medium, and mix the hydroxyapatite sheets of the control group and the experimental group with 3 mL of saliva medium;

[0120] (4) Incubate overnight for 12 h and detect the methyl mercaptan peak area.

[0121] Table 3

[0122]

[0123]

[0124] It can be seen from the data in Table 3 that the toothpaste prepared by the present invention has a good effect of refreshing breath, and the honeysuckle extract, field mint extract and yeast fermentation product extract have a certain synergistic effect on the above effect.

[0125] The applicant declares that the present invention uses the above-mentioned embodiments to illustrate a breath freshening toothpaste and a preparation method thereof, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of various raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0126] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, a variety of simple modifications can be made to the technical solution of the present invention, and these simple modifications all belong to the protection scope of the present invention.

[0127] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

Claims

1. A toothpaste for freshening breath, characterized in that: The toothpaste is prepared by comprising a breath freshening composition, a foaming agent, an abrasive, a thickener and water. The breath freshening composition comprises honeysuckle flower extract, field mint extract and yeast fermentation product extract.

2. The breath freshening toothpaste according to claim 1, characterized in that: The raw materials for preparing the toothpaste include, by weight, 1-3 parts of a breath freshening composition, 5-10 parts of a foaming agent, 18-24 parts of an abrasive, 0.5-1.5 parts of a thickener, and 20-30 parts of water; Preferably, the breath-freshening composition comprises, by weight, 1-3 parts of honeysuckle extract, 1-3 parts of field mint extract, and 0.1-1 part of yeast fermentation product extract.

3. The breath freshening toothpaste according to claim 1 or 2, characterized in that: The foaming agent includes any one of cocamidopropyl betaine, sodium lauryl sulfate, and polyethylene glycol-32, or a combination of at least two thereof; Preferably, the thickener comprises xanthan gum and / or hydroxyethyl cellulose; Preferably, the abrasive comprises hydrated silica.

4. The breath freshening toothpaste according to any one of claims 1 to 3, characterized in that: The raw materials for preparing the toothpaste further include any one of a moisturizer, a fragrance, a preservative, an anti-caries agent, a pH regulator or a taste improver, or a combination of at least two thereof.

5. The breath freshening toothpaste according to claim 4, characterized in that: The toothpaste preparation raw materials also include, by weight, any one of 32-40 parts of moisturizer, 0.1-0.5 parts of fragrance, 0.1-0.8 parts of preservative, 0.1-0.5 parts of anti-caries agent, 0.1-0.5 parts of pH regulator or 0.1-1 parts of taste improver, or a combination of at least two of them.

6. The breath freshening toothpaste according to claim 4 or 5, characterized in that: The moisturizing agent includes any one of glycerin, sorbitol, tranexamic acid, bisabolol, ginger root extract, persimmon fruit extract, or a combination of at least two thereof; Preferably, the fragrance comprises essence.

7. The breath freshening toothpaste according to any one of claims 4 to 6, characterized in that: The preservative includes methylpropanediol and / or o-cymene-5-ol; Preferably, the anticaries agent comprises sodium fluoride.

8. The breath freshening toothpaste according to any one of claims 4 to 7, characterized in that: The pH adjuster includes sodium hydroxide.

9. The breath freshening toothpaste according to any one of claims 4 to 8, characterized in that: The taste improver includes galactose.

10. A method for preparing a breath freshening toothpaste according to any one of claims 1 to 9, characterized in that: The preparation method comprises: physically mixing the preparation raw materials and defoaming to obtain the product.

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