Traditional Chinese medicine oral composition for treating vitiligo and preparation method thereof

Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly provides an oral traditional Chinese medicine composition for treating leucoderma and a preparation method thereof. The traditional Chinese medicine composition is prepared from semen cuscutae, fructus schizandrae, fructus polygoni orientalis, semen astragali complanati, radix clematidis, duckweed, folium ilicis cornutae, rhizoma chuanxiong, rhizoma cyperi, liquorice root, cortex cinnamomi and forged oyster shell as raw materials according to a proper weight ratio. Wherein the semen cuscutae, the flatstem milkvetch seed and the folium ilicis cornutae tonify The radix clematidis and the duckweed dispel wind and dredge collaterals, the schisandra chinensis and the calcined oyster shell astringe and induce astringency, the rhizoma cyperi, the ligusticum wallichii and the fructus polygoni orientalis regulate qi and activate blood, and the honey The traditional Chinese medicine composition has the effects of tonifying liver and kidney, regulating qi and blood, activating blood and dispelling wind, can promote color recovery of decolored parts of a patient to reduce the area of leukoplakia of the patient, and can improve unhealthy emotion of the patient by integrally regulating qi and blood of viscera.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine oral composition for treating vitiligo and a preparation method thereof. Background Art

[0002] Vitiligo is an acquired disease in which the body's melanocytes cannot play their physiological role normally due to one or more reasons, causing idiopathic damage, leading to systemic or local skin depigmentation. The main manifestation is a significant difference between the skin lesions and the body's normal skin color. The global incidence of the disease is 0.5%-2%. It is a widespread skin depigmentation disease. The direct cause of the disease is that the functional melanocytes in the hair follicles or skin tissues cannot play their physiological role normally due to one or more reasons in the skin lesions, resulting in systemic or local white spots on the skin.

[0003] Since the pathogenesis of vitiligo has not been fully elucidated, there is a lack of targeted treatment methods. At present, there is no specific drug that can completely cure vitiligo. Existing treatment methods such as phototherapy, drug therapy, transplantation therapy, etc., although there are certain effects, single therapy is often difficult to achieve the desired effect. In addition, existing therapeutic drugs such as calcineurin inhibitors, glucocorticoids, vitamin D3 derivatives, etc., have not been approved for vitiligo indications, and there are problems with large side effects. Although new technologies such as JAK inhibitors and hair follicle melanocyte transplantation have emerged in recent years, the efficacy evaluation, clinical application and promotion of these technologies are still facing challenges. For example, the safety and long-term efficacy of JAK inhibitors still require more clinical observation and research. The treatment of vitiligo usually takes a long time to take effect, and the efficacy varies from person to person. Some patients have poor color restoration after treatment, and even relapse. According to statistics, about 40% of patients will relapse within one year after treatment, and the color restoration rate is low. Therefore, even if the condition is controlled after treatment, it may relapse or spread due to various predisposing factors, requiring continuous and long-term attention and management. Even if the condition is controlled during treatment, once treatment is stopped, white spots may reappear. This shows that existing treatments cannot fundamentally eliminate the cause of the disease, but can only temporarily control the condition. In addition, vitiligo patients often experience anxiety, inferiority, irritability and other emotions due to the impact of the disease. These emotional fluctuations may prolong the treatment cycle and increase the difficulty of treatment. The cost of treatment is high, especially for patients who require long-term treatment, the economic burden is heavy.

[0004] At present, the oral drugs for vitiligo in traditional Chinese medicine and ethnic medicine include Vitiligo Pills (capsules), Bailing Tablets, Baishi Pills, Qubai Babuqi Tablets, Compound Antiparasitic Vernonia Tablets, etc. However, it is difficult for the above drugs to reach a consistent ideal state due to multiple factors such as the effect, treatment cycle, and economic cost, resulting in limited clinical application and promotion. Therefore, there is an urgent need for a Chinese medicine formula for vitiligo treatment that can significantly improve the effect, shorten the treatment time, and reduce recurrence. Summary of the invention

[0005] In order to solve the above problems existing in the prior art, the present invention provides a Chinese medicine oral composition for treating vitiligo with significant effect, short treatment time and low recurrence rate and its preparation method. The Chinese medicine composition of the present invention can promote the recoloration of the depigmented parts of the patient, reduce the area of ​​the white spots of the patient, lighten the color, and completely disappear in some parts. At the same time, by regulating the qi and blood of the internal organs as a whole, the overall state of the patient is improved and the recurrence is inhibited.

[0006] The technical solution adopted by the present invention is: The first aspect of the present invention provides a Chinese medicine oral composition for treating vitiligo, the raw material components comprising: 10-25 weight parts of Cuscuta seeds, 5-15 weight parts of Schisandra chinensis, 5-20 weight parts of Polygonum multiflorum seeds, 5-20 weight parts of Astragalus membranaceus seeds, 5-20 weight parts of Clematis chinensis, 3-10 weight parts of Duckweed, 5-20 weight parts of Holly leaves, 5-20 weight parts of Chuanxiong, 5-20 weight parts of Cyperus rotundus, 5-20 weight parts of Licorice, 5-20 weight parts of cinnamon bark, and 5-20 weight parts of Oyster shell.

[0007] It is further preferred that the raw material components of the Chinese medicine oral composition for treating vitiligo include: 17.5 parts by weight of Cuscuta seeds, 10 parts by weight of Schisandra chinensis, 12.5 parts by weight of Polygonum multiflorum, 12.5 parts by weight of Astragalus membranaceus, 12.5 parts by weight of Clematidis, 6.5 parts by weight of Duckweed, 12.5 parts by weight of Holly leaves, 12.5 parts by weight of Ligusticum chuanxiong, 12.5 parts by weight of Cyperus rotundus, 12.5 parts by weight of Licorice, 12.5 parts by weight of Cinnamon bark, and 12.5 parts by weight of Oyster shell.

[0008] The licorice is roasted licorice.

[0009] The second aspect of the present invention provides a method for preparing the Chinese medicine oral composition for treating vitiligo, comprising the following steps: (S1) taking the above raw material components by weight, mixing them evenly, and crushing them to obtain Chinese medicine powder; (S2) adding water to the Chinese medicine powder obtained in step S1 for reflux extraction to obtain a raw material medicine solution; (S3) filtering and concentrating the raw material drug solution obtained in step S2 to obtain a concentrate; (S4) Drying and crushing the concentrate obtained in step S3 to obtain a Chinese medicine composition for internal use.

[0010] In step (S1), the particle size of the traditional Chinese medicine powder is 20-60 meshes.

[0011] In step (S2), the mass ratio of the traditional Chinese medicine powder to the added water is 1:4-1:8.

[0012] In step (S2), the reflux extraction time is 1-2 hours.

[0013] In step (S2), the reflux extraction is repeated 2-3 times.

[0014] In step (S3), the concentration is concentrated under reduced pressure to a thick paste with a relative density of 1.30-1.35.

[0015] In step (S4), the drying temperature is 80-120°C.

[0016] Cuscuta chinensis is sweet and warm in nature. It nourishes the liver and kidneys, consolidates the essence and reduces urine, stabilizes the fetus, improves eyesight, and stops diarrhea. It is used for impotence and spermatorrhea, residual urine, enuresis and frequent urination, soreness of the waist and knees, blurred vision and tinnitus, kidney deficiency and fetal leakage, restless fetal movement, spleen and kidney deficiency diarrhea; external treatment of vitiligo.

[0017] Schisandrae Chinensis, sour and sweet, warm in nature. It can nourish the lungs, nourish the kidneys, promote the production of body fluids, stop sweating, and astringe semen. It can treat asthma and cough due to lung deficiency, dry mouth and thirst, spontaneous sweating, night sweats, emaciation due to fatigue, nocturnal emission and spermatorrhea, and chronic diarrhea and dysentery.

[0018] Red Flower Seed, salty in taste, slightly cold in nature. It can disperse blood and relieve symptoms, eliminate stagnation and relieve pain. It is used for lumps and masses, goiter and tumor swelling and pain, indigestion, and stomach distension and pain.

[0019] Astragalus membranaceus, sweet in taste, warm in nature. It warms and nourishes the liver and kidneys, consolidates the essence, reduces urine, and improves eyesight. It is used for kidney deficiency and low back pain, spermatorrhea and premature ejaculation, leukorrhea, residual urine, and dizziness.

[0020] Clematis chinensis is pungent, salty and warm in nature. It has the effects of dispelling wind and dampness, dredge meridians and relieve pain, and eliminate bone stagnation. It can be used to treat rheumatic arthralgia, flexion and extension difficulties, cold pain in the waist and knees, numbness of limbs, tetanus, etc.

[0021] Duckweed, spicy, cold in nature. It can dissipate wind-heat, cure rashes, and promote diuresis. It is used for measles that does not cure, urticaria itching, edema and oliguria.

[0022] Holly leaves are bitter and cool in nature. They clear away heat, nourish yin, soothe the liver, and benefit the kidneys. They are used for pulmonary tuberculosis, hemoptysis, bone steaming, hot flashes, dizziness, and hypertension.

[0023] Chuanxiong, spicy, warm in nature. It promotes blood circulation and qi, dispels wind and relieves pain. It is used for irregular menstruation, amenorrhea, dysmenorrhea, abdominal pain due to abdominal masses, stabbing pain in the chest and ribs, swelling and pain due to falls, headache, and rheumatic pain.

[0024] Cyperus rotundus is pungent, slightly bitter, sweet, and neutral in nature. It has the effects of soothing the liver and regulating qi, promoting blood circulation and regulating menstruation.

[0025] Licorice root, sweet in taste, neutral in nature. It nourishes the spleen and replenishes qi, clears away heat and detoxifies, removes phlegm and relieves cough, relieves pain, and harmonizes various medicines. It is used for spleen and stomach weakness, fatigue, palpitations and shortness of breath, cough with sputum, abdominal and limb cramps and pain, carbuncle, sore and ulcer, and relieves drug toxicity and potency.

[0026] Cinnamon bark is pungent and sweet in taste and very hot in nature. It replenishes fire and boosts yang, guides fire back to its source, dispels cold and relieves pain, and activates blood circulation and dredges menstruation. It is used for impotence, cold uterus, cold pain in waist and knees, wheezing due to kidney deficiency, dizziness due to yang deficiency, red eyes and sore throat, cold pain in the heart and abdomen, vomiting and diarrhea due to deficiency and cold, cold hernia, running pig, amenorrhea, and dysmenorrhea.

[0027] Forged oyster, salty in taste, slightly cold in nature. It can restrain yin and suppress yang, stop sweating and restrain semen, resolve phlegm and soften hard masses. It can treat epilepsy, spontaneous sweating, night sweats, spermatorrhea, stranguria, metrorrhagia, leukorrhea, scrofula, goiter, vertigo, tinnitus, lumps, stomachache and heartburn. Forged oyster can astringe and consolidate.

[0028] The present invention has the following beneficial effects: The present invention provides a Chinese medicine oral composition for treating vitiligo, by using Cuscuta, Schisandra, Fructus Polygoni Multiflori, Fructus Astragali, Radix Clematis, Duckweed, Folium Lycii, Rhizoma Chuanxiong, Rhizoma Cyperi, Radix Glycyrrhizae, Cortex Cinnamomi, Folium Concha Ostreae as raw materials and carrying out appropriate weight proportion; wherein Cuscuta, Fructus Complanati, Folium Lycii nourish the liver and kidney; Rhizoma Clemati, Duckweed dispel wind and dredge collaterals, Fructus Schisandrae, Rhizoma Concha Ostreae astringent, Rhizoma Cyperi, Rhizoma Chuanxiong, Fructus Polygoni Multiflori regulate qi and activate blood circulation, and Radix Glycyrrhizae uralensis harmonizes various medicines. Various medicines are used together, synergistically, and play the effects of nourishing the liver and kidney, harmonizing qi and blood, activating blood circulation and dispelling wind, not only can promote the restoration of color of the patient's decolorized part, so that the patient's white spot area is reduced, but also can improve the patient's bad mood by regulating the qi and blood of the internal organs as a whole. In addition, the medicine of the present invention is used in the treatment process of vitiligo patients, and under the premise of ensuring the curative effect, the amount of medicine used is reduced compared with the previous medicine, the cost of medicine is reduced, the medication time is shortened, and it is conducive to clinical promotion and application. DETAILED DESCRIPTION

[0029] To make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention.

[0030] Unless otherwise specified, the reagents involved in the specific embodiments of the present invention are all commercially available products and can be purchased through commercial channels.

[0031] In the following examples, 1 part by weight represents 1 g.

[0032] Example 1 This embodiment provides a Chinese medicine oral composition for treating vitiligo, and the raw material components include: 10 parts by weight of Cuscuta seeds, 15 parts by weight of Schisandra chinensis, 5 parts by weight of Polygonum multiflorum, 20 parts by weight of Astragalus membranaceus, 5 parts by weight of Clematidis, 10 parts by weight of Duckweed, 5 parts by weight of Holly leaves, 20 parts by weight of Chuanxiong, 5 parts by weight of Cyperus rotundus, 20 parts by weight of Radix Glycyrrhizae Preparata, 5 parts by weight of Cinnamon bark, and 20 parts by weight of Concha Ostreae.

[0033] The preparation method of the Chinese medicine oral composition for treating vitiligo is as follows: (S1) taking the above raw material components by weight, mixing them evenly, and crushing them to obtain a Chinese medicine powder with a particle size of 20 mesh; (S2) adding 4 times the mass of water to the Chinese medicine powder obtained in step S1 and subjecting it to reflux extraction for 2 hours. The reflux extraction is repeated twice, and the extracts are combined to obtain a raw material drug solution; (S3) filtering the raw material drug solution obtained in step S2, and then concentrating under reduced pressure to a thick paste with a relative density of 1.30, which is a concentrate; (S4) Drying and crushing the concentrate obtained in step S3 to obtain a Chinese medicine composition for internal use.

[0034] Example 2 This embodiment provides a Chinese medicine oral composition for treating vitiligo, and the raw material components include: 25 parts by weight of Cuscuta seeds, 5 parts by weight of Schisandra chinensis, 20 parts by weight of Polygonum multiflorum, 5 parts by weight of Astragalus membranaceus, 20 parts by weight of Clematidis, 3 parts by weight of Duckweed, 20 parts by weight of Holly leaves, 5 parts by weight of Chuanxiong, 20 parts by weight of Cyperus rotundus, 5 parts by weight of Radix Glycyrrhizae Preparata, 20 parts by weight of Cinnamon bark, and 5 parts by weight of Concha Ostreae.

[0035] The preparation method of the Chinese medicine oral composition for treating vitiligo is as follows: (S1) taking the above raw material components by weight, mixing them evenly, and crushing them to obtain a Chinese medicine powder with a particle size of 60 mesh; (S2) adding 8 times the mass of water to the Chinese medicine powder obtained in step S1 and subjecting it to reflux extraction for 1 hour. The reflux extraction is repeated 3 times, and the extracts are combined to obtain a raw material drug solution; (S3) filtering the raw material drug solution obtained in step S2, and then concentrating under reduced pressure to a thick paste with a relative density of 1.35, which is a concentrate; (S4) Drying and crushing the concentrate obtained in step S3 to obtain a Chinese medicine composition for internal use.

[0036] Example 3 This embodiment provides a Chinese medicine oral composition for treating vitiligo, and the raw material components include: 17.5 parts by weight of Cuscuta seeds, 10 parts by weight of Schisandra chinensis, 12.5 parts by weight of Polygonum multiflorum, 12.5 parts by weight of Astragalus membranaceus, 12.5 parts by weight of Clematidis, 6.5 parts by weight of Duckweed, 12.5 parts by weight of Holly leaves, 12.5 parts by weight of Ligusticum chuanxiong, 12.5 parts by weight of Cyperus rotundus, 12.5 parts by weight of Licorice, 12.5 parts by weight of Cinnamon bark, and 12.5 parts by weight of Oyster shell.

[0037] The preparation method of the Chinese medicine oral composition for treating vitiligo is as follows: (S1) taking the above raw material components by weight, mixing them evenly, and crushing them to obtain a Chinese medicine powder with a particle size of 40 mesh; (S2) adding 6 times the mass of water to the Chinese medicine powder obtained in step S1 and subjecting it to reflux extraction for 1.5 hours. The reflux extraction is repeated twice, and the extracts are combined to obtain a raw material drug solution; (S3) filtering the raw material drug solution obtained in step S2, and then concentrating under reduced pressure to a thick paste with a relative density of 1.32, which is a concentrate; (S4) Drying and crushing the concentrate obtained in step S3 to obtain a Chinese medicine composition for internal use.

[0038] Example 4 This embodiment provides a Chinese medicine oral composition for treating vitiligo, and the raw material components include: 17.5 parts by weight of Cuscuta seeds, 10 parts by weight of Schisandra chinensis, 12.5 parts by weight of Polygonum multiflorum, 12.5 parts by weight of Astragalus membranaceus, 12.5 parts by weight of Clematidis, 6.5 parts by weight of Duckweed, 12.5 parts by weight of Holly leaves, 12.5 parts by weight of Ligusticum chuanxiong, 12.5 parts by weight of Cyperus rotundus, 12.5 parts by weight of Licorice, 12.5 parts by weight of Cinnamon bark, and 12.5 parts by weight of Oyster shell.

[0039] The preparation method of the Chinese medicine oral composition for treating vitiligo is as follows: (S1) taking the above raw material components by weight, mixing them evenly, and crushing them to obtain a Chinese medicine powder with a particle size of 20-60 mesh; (S2) Add 4-8 times the mass of water to the Chinese medicine powder obtained in step S1 and boil for 1 hour to obtain a Chinese medicine liquid, which is a Chinese medicine oral composition.

[0040] Example 5 This embodiment provides a Chinese medicine oral composition for treating vitiligo, and the raw material components include: 17.5 parts by weight of Cuscuta seeds, 10 parts by weight of Schisandra chinensis, 12.5 parts by weight of Polygonum multiflorum, 12.5 parts by weight of Astragalus membranaceus, 12.5 parts by weight of Clematidis, 6.5 parts by weight of Duckweed, 12.5 parts by weight of Holly leaves, 12.5 parts by weight of Ligusticum chuanxiong, 12.5 parts by weight of Cyperus rotundus, 12.5 parts by weight of Licorice, 12.5 parts by weight of Cinnamon bark, and 12.5 parts by weight of Oyster shell.

[0041] The preparation method of the Chinese medicine oral composition for treating vitiligo is as follows: (S1) taking the above raw material components by weight, mixing them evenly, and crushing them to obtain a Chinese medicine powder with a particle size of 40 mesh; (S2) adding 6 times the mass of water to the Chinese medicine powder obtained in step S1 and performing reflux extraction for 1.5 hours, combining the extracts to obtain a raw material medicine solution; (S3) filtering the raw material drug solution obtained in step S2, and then concentrating under reduced pressure to a thick paste with a relative density of 1.33, which is a concentrate; (S4) Drying and crushing the concentrate obtained in step S3 to obtain a Chinese medicine composition for internal use.

[0042] Experimental example The clinical efficacy of the Chinese medicine oral composition obtained in Example 3 for the treatment of vitiligo was evaluated. 45 patients who visited the outpatient clinic of Beijing Hospital of Traditional Chinese Medicine from January 1, 2023 to June 1, 2024 and were diagnosed with vitiligo in accordance with the diagnostic criteria of the "Consensus on Diagnosis and Treatment of Vitiligo (2021 Edition)" issued by the Chinese Society of Integrated Traditional Chinese and Western Medicine were observed. The oral Chinese medicine oral regimen was combined with narrow-spectrum UVB irradiation once a week, with an observation period of 6 months (24 weeks), and the vitiligo area score index (VASI) was used as the main observation indicator. The nimodipine method was used to calculate the change rate of the main observation indicator vitiligo area score index (VASI) before and after treatment, and the efficacy was evaluated.

[0043] Calculation formula of the nimodipine method: efficacy index (n) = (VASI score before treatment - VASI score after treatment) / VASI score before treatment × 100%.

[0044] Cured: All white spots return to normal skin color; Significantly effective: white spots are significantly reduced and pigment is regenerated (n≥50%); Effective: White spots shrink and regenerate pigment (50%>n≥10%); Ineffective: There was no reduction in the size of the white spots and no regeneration of pigment (n < 10%).

[0045] The results are shown in Table 1.

[0046] Table 1-Effect evaluation of the Chinese medicine oral composition obtained in Example 3 As can be seen from Table 1, among the 45 patients, 2 were cured, with a cure rate of 4.4%; 33 were significantly effective, with a significant efficacy rate of 73.3%; and 10 were effective, with an effective rate of 22.2%. This shows that the Chinese medicine oral composition obtained in Example 3 has a good therapeutic effect.

[0047] 2. Clinical Cases: The results showed that the Chinese medicine composition of the present invention has good clinical efficacy, and no obvious adverse reactions occurred in all patients during the Chinese medicine treatment.

[0048] Typical cases: Typical case 1: Male, 45 years old, visited the hospital on April 2, 2023. The patient had vitiligo for 3 years, was irritable, had multiple white spots of different sizes on the trunk and back of the hands, had been treated with tacrolimus ointment, and took compound glycyrrhizin orally, and had worsened in the past six months. After 5 months of treatment with the Chinese medicine composition of Example 3 of the present invention, all white spots became lighter, most of the white spots were smaller than before, and the rash area was reduced by more than 80%, so the drug was discontinued, and follow-up was conducted for 3 and 6 months after discontinuation of the drug, with no recurrence.

[0049] Typical case 2: Female, 38 years old, visited the hospital on June 18, 2023. The patient had vitiligo for 10 years, was under great pressure, had multiple white spots of different sizes on the abdomen, back, and had used tacrolimus ointment, halometasone ointment, compound calciferol tincture and other external applications, oral glucocorticoids, compound glycyrrhizic acid glycosides, white peony total glucosides tablets and other treatments, but the effect was not good and the aggravation was in the past six months. After one year of treatment with the Chinese medicine composition of Example 3 of the present invention, the area of ​​white spots was reduced by more than 60% compared with before, and the patient complained that his mood was improved compared with before, and there was no recurrence after 3 months of follow-up.

[0050] Typical case 3: Male, 38 years old, visited the hospital on August 2, 2024. The patient had vitiligo for 5 years and was under great pressure. There were multiple white spots of different sizes on the scalp, corners of the mouth, hands, and back. He had used halometasone ointment, injected once a month, and taken compound glycyrrhizin orally. The symptoms worsened in the past six months. After 4 months of treatment with the Chinese medicine composition of Example 1 of the present invention, the white spots became lighter, some of the white spots were light red, and the area was smaller than before. At the same time, the patient complained that his mood was improved compared with before.

[0051] Typical case 4: male, 20 years old, visited the hospital on October 21, 2024. The patient had vitiligo for 3 months, with white spots on the inner side of the right upper limb and the inner side of the right palm. After 4 months of treatment with the Chinese medicine composition of Example 2 of the present invention, the area of ​​the white spots was smaller than before, and color islands were visible on them.

[0052] Typical case 5: Female, 52 years old, visited the hospital on October 14, 2024. The patient had vitiligo for more than one year, with multiple white spots on the trunk and left calf. She had taken oral Chinese medicine and 308 local irradiation treatment, but the effect was not good. After 2 months of treatment with the Chinese medicine composition of Example 1 of the present invention, the area of ​​the white spots was smaller than before, and color islands could be seen around them.

[0053] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any person skilled in the art can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A Chinese medicinal composition for internal use for treating vitiligo, characterized in that: The raw material components include: 10-25 weight parts of Cuscuta seeds, 5-15 weight parts of Schisandra chinensis, 5-20 weight parts of Polygonum multiflorum seeds, 5-20 weight parts of Astragalus membranaceus seeds, 5-20 weight parts of Clematis chinensis, 3-10 weight parts of Duckweed, 5-20 weight parts of Holly leaves, 5-20 weight parts of Chuanxiong, 5-20 weight parts of Cyperus rotundus, 5-20 weight parts of Licorice, 5-20 weight parts of cinnamon bark, and 5-20 weight parts of Oyster shell.

2. The Chinese medicinal composition for treating vitiligo according to claim 1, characterized in that: The raw material components include: 17.5 parts by weight of Cuscuta seeds, 10 parts by weight of Schisandra chinensis, 12.5 parts by weight of Polygonum multiflorum, 12.5 parts by weight of Astragalus membranaceus, 12.5 parts by weight of Clematidis, 6.5 parts by weight of Duckweed, 12.5 parts by weight of Holly leaves, 12.5 parts by weight of Ligusticum chuanxiong, 12.5 parts by weight of Cyperus rotundus, 12.5 parts by weight of Licorice, 12.5 parts by weight of Cinnamon bark, and 12.5 parts by weight of Oyster shell.

3. The Chinese medicinal composition for treating vitiligo according to claim 1, characterized in that: The licorice is roasted licorice.

4. The method for preparing the Chinese medicinal composition for treating vitiligo according to any one of claims 1 to 3, characterized in that: The steps include: (S1) taking the above raw material components by weight, mixing them evenly, and crushing them to obtain Chinese medicine powder; (S2) adding water to the Chinese medicine powder obtained in step S1 for reflux extraction to obtain a raw material medicine solution; (S3) filtering and concentrating the raw material drug solution obtained in step S2 to obtain a concentrate; (S4) Drying and crushing the concentrate obtained in step S3 to obtain a Chinese medicine composition for internal use.

5. The method for preparing the Chinese medicinal composition for treating vitiligo according to claim 4, characterized in that: In step (S1), the particle size of the traditional Chinese medicine powder is 20-60 mesh.

6. The method for preparing the Chinese medicinal composition for treating vitiligo according to claim 4, characterized in that: In step (S2), the mass ratio of the traditional Chinese medicine powder to the added water is 1:4-1:

8.

7. The method for preparing the Chinese medicinal composition for treating vitiligo according to claim 4, characterized in that: In step (S2), the reflux extraction time is 1-2 hours.

8. The method for preparing the Chinese medicinal composition for treating vitiligo according to claim 7, characterized in that: In step (S2), the reflux extraction is repeated 2-3 times.

9. The method for preparing the Chinese medicinal internal composition for treating vitiligo according to claim 4, characterized in that: In step (S3), the concentration is concentrated under reduced pressure to a thick paste with a relative density of 1.30-1.

35.

10. The method for preparing the Chinese medicinal composition for treating vitiligo according to claim 4, characterized in that: In step (S4), the drying temperature is 80-120°C.

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