Treatment plan generation method, radiotherapy control method, system and equipment

Abstract

The invention provides a treatment plan generation method, a radiotherapy control method, a radiotherapy control system and equipment, relates to the technical field of medical treatment, and aims to solve the problem that precise radiotherapy requirements cannot be met and effectively support precise radiotherapy. The treatment plan generation method is applied to the radiotherapy system, and the radiotherapy system comprises a low-energy accelerator and an ultra-low-energy accelerator. The beam emitter is used for emitting beams to a target area of a target object; and the energy of the beam emitted by the low-energy accelerator is higher than that of the beam emitted by the ultra-low-energy accelerator. The treatment plan generation method comprises the steps of obtaining a volume image of a target object; target region information of the target object is determined based on the volume image, and the target region information comprises the position depth of a target region; acquiring prescription dose information of the target region; and generating a treatment plan according to the target region information and the prescription dose information of the target region, so that the control equipment controls a low-energy accelerator and / or an ultra-low-energy accelerator to emit a beam to the target region of the target object based on the treatment plan.

Description

Technical Field

[0001] The present application relates to the field of medical technology, and in particular to a treatment plan generation method, a radiotherapy control method, a system and a device. Background Art

[0002] Currently, circular accelerators have been rapidly developed in the field of radiotherapy, especially low-energy machines. For example, the single-photon 6MV low-energy machine uses a 6MV accelerator to perform radiotherapy on all types of diseases.

[0003] However, radiotherapy is shifting from general radiotherapy to precision radiotherapy. Precision radiotherapy requires providing the best personalized plan for each patient to achieve refined treatment and thus improve the effectiveness of treatment. Therefore, the current accelerator implementation method can no longer meet the needs of precision radiotherapy and is difficult to support the realization of precision radiotherapy. Summary of the invention

[0004] The present application provides a treatment plan generation method, a radiotherapy control method, a system and a device, which can improve the problem of not being able to meet the needs of precise radiotherapy and effectively support the realization of precise radiotherapy.

[0005] In a first aspect, the present application provides a treatment plan generation method, which is applied to a radiotherapy system. The radiotherapy system includes: a low-energy accelerator and an ultra-low-energy accelerator. The accelerator is used to emit a beam to a target area of ​​a target object. The energy of the beam emitted by the low-energy accelerator is higher than the energy of the beam emitted by the ultra-low-energy accelerator.

[0006] The treatment plan generation method includes: acquiring a volume image of a target object. Based on the volume image, determining target area information of the target object, wherein the target area information includes a position depth of the target area. The position depth of the target area is used to indicate the distance of the position of the target area relative to the body surface of the target object. Acquiring prescription dose information of the target area, wherein the prescription dose information includes radiation doses of target areas in different regions. A treatment plan is generated according to the target area information and the prescription dose information of the target area, so that a control device controls a low-energy accelerator and / or an ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan.

[0007] In some embodiments, a method for generating a treatment plan based on target area information and prescription dose information of the target area so that a control device controls a low-energy accelerator and / or an ultra-low-energy accelerator to emit a beam to a target area of ​​a target object based on the treatment plan specifically includes: when the position depth of the target area is less than or equal to a preset depth threshold, generating a treatment plan based on the target area information and prescription dose information of the target area so that the control device controls an ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan. Alternatively, when the position depth of the target area is greater than the preset depth threshold, generating a treatment plan based on the target area information and prescription dose information of the target area so that the control device controls a low-energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan, or controlling a low-energy accelerator and an ultra-low-energy accelerator to simultaneously emit a beam to the target area of ​​the target object.

[0008] In a second aspect, the present application provides a radiotherapy control method, which is applied to a radiotherapy system. The radiotherapy system includes: a low-energy accelerator and an ultra-low-energy accelerator. It is used to emit a beam to a target area of ​​a target object. The energy of the beam emitted by the low-energy accelerator is higher than the energy of the beam emitted by the ultra-low-energy accelerator.

[0009] The radiotherapy control method includes: obtaining a treatment plan, the treatment plan includes target area information of a target object, the target area information includes a position depth of the target area. The position depth of the target area is used to indicate the distance between the position of the target area and the body surface of the target object. Based on the position depth of the target area, a low-energy accelerator and / or an ultra-low-energy accelerator is controlled to emit a beam to the target area of ​​the target object.

[0010] In some embodiments, based on the position depth of the target area, the method of controlling a low-energy accelerator and / or an ultra-low-energy accelerator to emit a beam to the target area of ​​the target object specifically includes: when the position depth of the target area is less than or equal to a preset depth threshold, controlling the ultra-low-energy accelerator to emit a beam to the target area of ​​the target object. Alternatively, when the position depth of the target area is greater than the preset depth threshold, controlling the low-energy accelerator, or controlling the low-energy accelerator and the ultra-low-energy accelerator to simultaneously emit a beam to the target area of ​​the target object.

[0011] In a third aspect, the present application provides a radiotherapy system, the radiotherapy system comprising: a TPS device, used to execute any possible treatment plan generation method as in the first aspect. A control device, used to execute any possible radiotherapy control method as in the second aspect. The radiotherapy device comprises: a low-energy accelerator and an ultra-low-energy accelerator. Used to emit a beam to a target area of ​​a target object. The energy of the beam emitted by the low-energy accelerator is higher than the energy of the beam emitted by the ultra-low-energy accelerator.

[0012] In some embodiments, the energy of the ultra-low energy accelerator is adjustable, and the energy range of the ultra-low energy accelerator may be 300 kilo volt (kV)-1250 kV. The energy of the low energy accelerator is, for example, 6 mega volt (MV).

[0013] In some embodiments, the radiotherapy device may further include: a rotatable annular frame. The low-energy accelerator and the ultra-low-energy accelerator are arranged on the rotatable annular frame. The irradiation isocenter of the low-energy accelerator and the irradiation isocenter of the ultra-low-energy accelerator are located in the same horizontal plane and are focused on the same point.

[0014] In some embodiments, the radiotherapy device may further include: a single-layer grating component. The single-layer grating component is arranged at the beam-out side of the ultra-low energy accelerator to adjust the shape of the radiation field of the beam emitted by the ultra-low energy accelerator.

[0015] In some embodiments, the radiotherapy device may further include: a flat panel detector. The flat panel detector is arranged on a rotatable annular frame and is arranged opposite to the ultra-low energy accelerator, and is used to receive the beam emitted by the ultra-low energy accelerator and passing through the target area of ​​the target object, and generate image information of the target area of ​​the target object, and the image information of the target area of ​​the target object is used to reflect the position change of the target area of ​​the target object.

[0016] In some embodiments, the radiotherapy device may further include: one or more radiation therapy heads. The irradiation isocenter of the low-energy accelerator, the irradiation isocenter of the ultra-low-energy accelerator, and the irradiation isocenter of the one or more radiation therapy heads are located in the same horizontal plane and are focused on the same point. The control device is also used to control the one or more radiation therapy heads to simultaneously emit beams to the target area of ​​the target object based on the treatment plan.

[0017] In a fourth aspect, the present application provides an electronic device, the electronic device comprising: a processor. A memory configured to store processor executable instructions. The processor is configured to execute the instructions to implement any possible treatment plan generation method as described in the first aspect, or any possible radiotherapy control method as described in the second aspect.

[0018] In a fifth aspect, the present application provides a non-volatile storage medium having a computer program stored thereon. When the computer program is read and executed, it implements any possible treatment plan generation method as in the first aspect, or any possible radiotherapy control method as in the second aspect.

[0019] In a sixth aspect, the present application provides a computer program product, which includes computer instructions. When the computer instructions are executed on an electronic device, the electronic device executes any possible treatment plan generation method as described in the first aspect, or any possible radiotherapy control method as described in the second aspect.

[0020] These and other aspects of the present application will become more apparent from the following description.

[0021] The technical solution provided by this application brings at least the following beneficial effects:

[0022] In this application, considering that rays of different energies have different properties and are adapted to different radiotherapy depths, a radiotherapy system is provided including a low-energy accelerator and an ultra-low-energy accelerator, and the energy of the beam emitted by the low-energy accelerator is higher than the energy of the beam emitted by the ultra-low-energy accelerator. This application can design a corresponding treatment plan based on the position depth of the target area of ​​the target object, and the control device can control the low-energy accelerator and / or the ultra-low-energy accelerator to irradiate the target area based on the treatment plan, which can improve the application flexibility of the radiotherapy system and broaden the range of treatable diseases.

[0023] In the radiotherapy system of the present application, after the TPS device obtains the volume image of the target object, it can determine the target area information of the target object based on the volume image. The target area information includes the position depth of the target area. The position depth of the target area is used to indicate the distance between the position of the target area and the body surface of the target object. Further, the TPS device can generate a treatment plan based on the target area information and the prescription dose information of the target area, so that the control device controls the low-energy accelerator and / or ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan. In this way, the embodiment of the present application can support radiotherapy using an energy-matched accelerator based on the position depth of the target area, can take into account the treatment of superficial tumors and deep tumors, provide more sophisticated treatment methods for different types of diseases, effectively meet the needs of precision radiotherapy, and support the realization of precision radiotherapy.

[0024] Moreover, compared with the method in the related art that uses a single energy accelerator for irradiation of the target area at any position and depth, the present application can use an ultra-low energy accelerator to accumulate energy for superficial tumors, which can effectively meet the target area dose requirements while reducing radiation to normal tissues, and has fewer toxic side effects on pediatric patients, which can make up for the shortcomings of using only conventional 6MV accelerators for irradiation, and can effectively support the realization of precision radiotherapy. In the present application, the ultra-low energy accelerator is set on a rotatable ring frame, which can support total body irradiation (TBI) of superficial tumors and achieve high-quality treatment of superficial tumors.

[0025] Furthermore, the ultra-low energy accelerator of the present application can be used for image guidance and auxiliary treatment while being used for treatment, so as to achieve real-time monitoring of the target area of ​​the target object during the treatment process without causing additional doses to the patient, thus achieving true real-time image guidance. The energy of the ultra-low energy accelerator of the present application is adjustable, and more accurate and clear images can be obtained for different patients. Moreover, compared with the method of obtaining images using a tube, the ultra-low energy accelerator has a longer service life, which can reduce the maintenance pressure and cost at the actual deployment site. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art are briefly introduced below.

[0027] Figure 1 A schematic diagram of the relationship between radiation dose and radiation depth provided in an embodiment of the present application;

[0028] Figure 2 A flowchart of a treatment plan generation method provided in an embodiment of the present application;

[0029] Figure 3 A schematic diagram of a flow chart of a radiotherapy control method provided in an embodiment of the present application;

[0030] Figure 4 A schematic diagram of the structure of a radiotherapy system provided in an embodiment of the present application;

[0031] Figure 5 A schematic diagram of the structure of a treatment plan generating device provided in an embodiment of the present application;

[0032] Figure 6 A schematic diagram of the structure of a radiotherapy control device provided in an embodiment of the present application;

[0033] Figure 7 A schematic diagram of the structure of a radiotherapy device provided in an embodiment of the present application;

[0034] Figure 8 A schematic diagram of the structure of another radiotherapy device provided in an embodiment of the present application;

[0035] Fig. 9 A schematic diagram of the structure of an electronic device provided in an embodiment of the present application;

[0036] Fig.10 A schematic diagram of the structure of another electronic device provided in an embodiment of the present application. DETAILED DESCRIPTION

[0037] The following will describe in detail the treatment plan generation method, radiotherapy control method, system and device provided in the embodiments of the present application in conjunction with the accompanying drawings.

[0038] In addition, the terms "including" and "having" and any variations thereof mentioned in the description of the present application are intended to cover non-exclusive inclusions. For example, a process, method, system, product or device comprising a series of steps or units is not limited to the listed steps or units, but may optionally include other steps or units that are not listed, or may optionally include other steps or units that are inherent to these processes, methods, products or devices.

[0039] It should be noted that, in the embodiments of the present application, words such as "exemplarily" or "for example" are used to indicate examples, illustrations or explanations. Any embodiment or design described as "exemplarily" or "for example" in the embodiments of the present application should not be interpreted as being more preferred or more advantageous than other embodiments or designs. Specifically, the use of words such as "exemplarily" or "for example" is intended to present related concepts in a specific way.

[0040] The term "and / or" used in the present application includes using either or both of the two methods.

[0041] The terms "first", "second" and "third" etc. in the specification and drawings of this application are used to distinguish different objects, rather than to describe the specific order of the objects, nor to indicate or imply relative importance or implicitly indicate the number of the indicated technical features.

[0042] In the description of the present application, unless otherwise specified, “plurality” means two or more.

[0043] The following explains some concepts involved in a treatment plan generation method, a radiotherapy control method, a system and a device provided in an embodiment of the present application.

[0044] Currently, circular accelerators have been rapidly developed in the field of radiotherapy, especially low-energy machines. For example, the single-photon 6MV low-energy machine uses a 6MV accelerator to perform radiotherapy on all types of diseases.

[0045] However, radiotherapy is shifting from general radiotherapy to precision radiotherapy. Precision radiotherapy requires providing the best personalized plan for each patient to achieve refined treatment and thus improve the effectiveness of treatment. Therefore, this method of using a single accelerator to achieve radiotherapy for all types of diseases can no longer meet the needs of precision radiotherapy and is difficult to support. It is easily constrained by treatment equipment and has poor therapeutic efficacy for skin lesions, breast, and pediatric patients.

[0046] In addition, the radiotherapy equipment commonly used in radiotherapy is also difficult to meet the needs of precision radiotherapy. For example, the gamma knife. The focus of the gamma knife is spherical, and the filling method is usually used to achieve coverage of the target area. However, when the gamma knife performs spherical filling on irregular target areas, the efficiency is low, and cold spots and hot spots of the dose are prone to occur. The conformal accuracy is poor and it is easily affected by the uneven dose distribution inside the target area.

[0047] In this case, it is considered that rays of different energies have different properties and are suitable for different radiation treatment depths. Figure 1 Schematic diagram of the relationship between radiation dose and radiation depth. Figure 1 The percentage depth dose (%) of electron beams, high-energy X-rays, gamma rays, neutron beams, kilovolt X-rays and heavy particle beams of different energies are shown, respectively, and the relationship between the radiation depth (cm) of the rays in the water phantom. Among them, high-energy X-rays can be megavolt X-rays. It can be seen that rays of different energies have different properties and are suitable for different radiotherapy depths. Ultra-low-energy rays can better accumulate energy at a smaller radiation depth (such as a shallow target area), and low-energy rays can better accumulate energy at a larger radiation depth (such as a deep target area).

[0048] In the treatment plan generation method of the first aspect of the present application:

[0049] In order to effectively meet the needs of precise radiotherapy for target areas at different depths, broaden the range of treatable diseases, and support the realization of precise radiotherapy, an embodiment of the present application provides a treatment plan generation method for application in a radiotherapy system.

[0050] The radiotherapy system comprises: a low-energy accelerator and an ultra-low-energy accelerator, which are used to emit a beam to a target area of ​​a target object. The energy of the beam emitted by the low-energy accelerator is higher than the energy of the beam emitted by the ultra-low-energy accelerator.

[0051] The treatment plan generation method includes: acquiring a volume image of a target object. Based on the volume image, determining target area information of the target object, wherein the target area information includes a position depth of the target area. The position depth of the target area is used to indicate the distance between the position of the target area and the body surface of the target object. Acquiring prescription dose information of the target area, wherein the prescription dose information includes radiation doses of target areas in different regions. A treatment plan is generated according to the target area information and the prescription dose information of the target area, so that a control device controls a low-energy accelerator and / or an ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan.

[0052] The present application can design a corresponding treatment plan based on the location depth of the target area of ​​the target object. The control device can control the low-energy accelerator and / or ultra-low-energy accelerator to irradiate the target area based on the treatment plan. The use of energy-matched accelerators for radiotherapy can take into account the treatment of superficial tumors and deep tumors, broaden the range of treatable diseases, and improve the application flexibility of the radiotherapy system.

[0053] like Figure 2 FIG. 1 is a flow chart of a treatment plan generation method provided in an embodiment of the present application. The treatment plan generation method includes: S101-S104.

[0054] S101: Acquire a volume image of a target object.

[0055] The volume image of the target object is an image obtained by performing an imaging examination on the patient, and is used to accurately reflect the condition of the tumor or lesion of the target object. The volume image of the target object includes the tumor or lesion in the target object. Or further, the volume image of the target object may also include normal tissue around the tumor or lesion in the target object.

[0056] Optionally, the volume image may be a three-dimensional image, such as a magnetic resonance (MR) image, a computed tomography (CT) image, or a positron emission tomography (PET) image.

[0057] S102: Determine target area information of the target object based on the volume image.

[0058] The target area information includes the position depth of the target area. The position depth of the target area is used to indicate the distance between the position of the target area and the body surface of the target object.

[0059] Optionally, the target area information may also include information such as the location and / or shape of the target area.

[0060] S103: Obtaining prescription dose information of the target area.

[0061] The prescription dose information includes radiation doses of target areas in different regions. Target areas in different regions may correspond to different radiation doses. The radiation dose is the amount of radiation energy that the target area needs to receive.

[0062] S104: Generate a treatment plan according to the target area information and the prescribed dose information of the target area, so that the control device controls the low-energy accelerator and / or the ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan.

[0063] In one possible approach, for a target area at a shallow depth, it is necessary to consider the dose distribution of radiation on the skin surface and in the shallow tissues, so as to effectively meet the dose requirements of such a target area while avoiding the problem of excessive dose causing damage to normal tissues. In this case, a treatment plan can be generated based on the information of the target area at a shallow depth and the prescription dose information of the target area, so that the control device controls the activation of the ultra-low energy accelerator based on the treatment plan, and does not activate the low-energy accelerator. Or further, the control device can also control the energy size of the ultra-low energy accelerator based on the treatment plan, so as to accurately set the energy of the ultra-low energy accelerator.

[0064] In another possible manner, for a target area with a relatively deep position, even if the ultra-low energy accelerator is adjusted to its maximum capacity, it may not be able to effectively meet the target area dose requirement. In this case, a treatment plan can be generated based on the information of the target area with a relatively shallow position and the target area's prescription dose information, so that the control device controls the activation of the low-energy accelerator based on the treatment plan, or the control device can also control the activation of the ultra-low energy accelerator and the low-energy accelerator at the same time based on the treatment plan, so as to meet the radiotherapy scenario.

[0065] In a possible manner, the method for generating a treatment plan may further include: determining the irradiation dose and irradiation time of the target area of ​​the target object according to the volume image of the target object and the prescription dose information of the target area, and generating a complete treatment plan.

[0066] In some embodiments, when the control device enables the ultra-low energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan instruction, the method for generating the treatment plan may further include: determining energy indication information of the ultra-low energy accelerator based on the prescription dose information of the target area, and adding the energy indication information to the treatment plan. The energy indication information is used to indicate the energy of the beam emitted by the ultra-low energy accelerator to the target area of ​​the target object.

[0067] In some embodiments, the method for generating a treatment plan may further include: determining that the position of the target area of ​​the target object has changed based on the image information of the target area of ​​the target object during the treatment process in combination with the volume image of the target object. Further, in the case where the position of the target area of ​​the target object has changed, the treatment plan may be updated based on the position change information of the target area of ​​the target object.

[0068] In one embodiment, in the above S104, a treatment plan is generated according to the target area information and the prescription dose information of the target area, so that the control device controls the low-energy accelerator and / or the ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan. The embodiment of the present application provides an optional implementation method, including: S1041-S1042.

[0069] S1041. When the position depth of the target area is less than or equal to a preset depth threshold, a treatment plan is generated according to the target area information and the prescription dose information of the target area, so that the control device controls the ultra-low energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan.

[0070] Considering that the ultra-low energy accelerator can effectively accumulate energy in superficial areas, it is more conducive to treating superficial lesions. If the depth of the target area is less than or equal to the preset depth threshold, the irradiation dose and irradiation time of the target area of ​​the target object can be determined based on the prescription dose information of the target area in the treatment plan to generate a complete treatment plan.

[0071] Optionally, the preset depth information can be flexibly set based on manual experience, or based on the treatment effect of the ultra-low energy accelerator on target areas at different depths, which is not limited in this application.

[0072] S1042. When the position depth of the target area is greater than a preset depth threshold, a treatment plan is generated according to the target area information and the prescription dose information of the target area, so that the control device controls the low-energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan, or controls the low-energy accelerator and the ultra-low-energy accelerator to simultaneously emit a beam to the target area of ​​the target object.

[0073] Considering that low-energy accelerators can effectively irradiate targets located deep below the body surface, if the target area is deeper than the preset depth threshold, the irradiation dose and irradiation time of the target area of ​​the target object by the low-energy accelerator can be determined based on the prescription dose information of the target area to generate a complete treatment plan.

[0074] Or further, in the case where the radiation dose requirement of the target area of ​​the target object is high, the method for generating a treatment plan may further include: determining the dose distribution of the low-energy accelerator and the ultra-low-energy accelerator according to the target area information and the prescription dose information of the target area, and generating a complete treatment plan. The control device may also simultaneously control the activation of the low-energy accelerator and the ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the above complete treatment plan.

[0075] In the radiotherapy control method of the second aspect of the present application:

[0076] The radiotherapy control method of the present application is applied to a radiotherapy system.

[0077] The radiotherapy system includes: a low-energy accelerator and an ultra-low-energy accelerator, which are used to emit a beam to a target area of ​​a target object. The energy of the beam emitted by the low-energy accelerator is higher than the energy of the beam emitted by the ultra-low-energy accelerator.

[0078] The radiotherapy control method comprises: obtaining a treatment plan, the treatment plan comprising target area information of the target object, the target area information comprising the position depth of the target area. The position depth of the target area is used to indicate the distance between the position of the target area and the body surface of the target object. Based on the position depth of the target area, a low-energy accelerator and / or an ultra-low-energy accelerator is controlled to emit a beam to the target area of ​​the target object.

[0079] like Figure 3 FIG. 2 is a flow chart of a radiotherapy control method provided in an embodiment of the present application. The radiotherapy control method is applied to a radiotherapy system. The radiotherapy control method includes: S201-S202.

[0080] S201. Obtain a treatment plan.

[0081] The treatment plan includes target area information of the target object. The target area information of the target object includes the position depth of the target area. The position depth of the target area is used to indicate the distance between the position of the target area and the body surface of the target object.

[0082] It should be understood that the method for generating the treatment plan can refer to the specific description in S101-S104 above, which will not be repeated here.

[0083] S202: Based on the position depth of the target area, control the low-energy accelerator and / or the ultra-low-energy accelerator to emit a beam to the target area of ​​the target object.

[0084] For targets at shallow depths, the ultra-low energy accelerator can be controlled to emit beams to the target area of ​​the target object according to the treatment plan, so as to effectively meet the dose requirements of such target areas while avoiding the problem of excessive dose causing damage to normal tissues.

[0085] For a target area at a deeper depth, the low-energy accelerator can be controlled to emit a beam to the target area of ​​the target object according to the treatment plan. Alternatively, the low-energy accelerator and the ultra-low-energy accelerator can be controlled to emit a beam to the target area of ​​the target object at the same time according to the treatment plan, so as to meet such radiotherapy scenarios requiring lower energy beams.

[0086] In one embodiment, in the above S202, that is, based on the position depth of the target area, when controlling the low-energy accelerator and / or the ultra-low-energy accelerator to emit a beam to the target area of ​​the target object, the embodiment of the present application provides an optional implementation method, including: S2021-S2022.

[0087] S2021. When the position depth of the target area is less than or equal to a preset depth threshold, control the ultra-low energy accelerator to emit a beam to the target area of ​​the target object.

[0088] If the depth of the target area is less than or equal to the preset depth threshold, the treatment plan can also indicate the energy and irradiation duration of the beam emitted to the target area of ​​the target object when the ultra-low energy accelerator is enabled. In this way, when the depth of the target area is less than or equal to the preset depth threshold, the energy of the beam emitted by the ultra-low energy accelerator can be adjusted, and according to the irradiation duration indicated by the treatment plan, the ultra-low energy accelerator can be controlled to emit a beam to the target area of ​​the target object, thereby achieving precise treatment of superficial parts.

[0089] S2022: When the position depth of the target area is greater than a preset depth threshold, control the low-energy accelerator, or control the low-energy accelerator and the ultra-low-energy accelerator to simultaneously emit a beam to the target area of ​​the target object.

[0090] If the depth of the target area is greater than the preset depth threshold, the treatment plan can indicate the control parameters such as the energy and irradiation duration of the beam emitted to the target area of ​​the target object when the low-energy accelerator is enabled. In this way, when the depth of the target area is greater than the preset depth threshold, the low-energy accelerator can be controlled to emit a beam to the target area of ​​the target object according to the control parameters indicated by the treatment plan, thereby achieving effective treatment of the deep target area.

[0091] Alternatively, the treatment plan may also indicate control parameters such as dose distribution information between the low-energy accelerator and the ultra-low-energy accelerator. Thus, when the depth of the target area is greater than a preset depth threshold, the low-energy accelerator and the ultra-low-energy accelerator may be controlled to simultaneously emit beams to the target area of ​​the target object according to the control parameters such as dose distribution information indicated in the treatment plan, thereby achieving effective treatment of the deep target area.

[0092] In the radiation therapy system of the third aspect of the present application:

[0093] Combined with the above Figure 2 The treatment plan generation method shown, and the above Figure 3 The radiotherapy control method shown in the embodiment of the present application provides a radiotherapy system. The radiotherapy system includes: a TPS device for executing the treatment plan generation method as described above, a control device for executing the radiotherapy control method as described above, and a radiotherapy device. The radiotherapy device includes: a low-energy accelerator and an ultra-low-energy accelerator; used to emit a beam to a target area of ​​a target object. The energy of the beam emitted by the low-energy accelerator is higher than the energy of the beam emitted by the ultra-low-energy accelerator.

[0094] In the radiotherapy system of the present application, after the TPS device obtains the volume image of the target object, it can determine the target area information of the target object based on the volume image. The target area information includes the position depth of the target area. The position depth of the target area is used to indicate the distance between the position of the target area and the body surface of the target object. Further, the TPS device can generate a treatment plan based on the target area information and the prescription dose information of the target area, so that the control device controls the low-energy accelerator and / or ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan. In this way, the embodiment of the present application can support radiotherapy using an energy-matched accelerator based on the position depth of the target area, can take into account the treatment of superficial tumors and deep tumors, provide more sophisticated treatment methods for different types of diseases, effectively meet the needs of precision radiotherapy, and support the realization of precision radiotherapy.

[0095] like Figure 4 , which is a schematic diagram of the structure of a radiotherapy system provided in an embodiment of the present application. Figure 4 The radiation therapy system 300 shown includes a TPS device 301, a control device 302, and a radiotherapy device 303. The control device 302 can be connected to the TPS device 301 and the radiotherapy device 303, respectively.

[0096] TPS equipment:

[0097] In some embodiments, the TPS device 301 is used to perform the above Figure 2 The treatment plan generation method shown is to obtain a volume image of the target object, and based on the volume image, determine the target area information of the target object, so as to further generate a treatment plan based on the target area information and the prescription dose information of the target area. Furthermore, the TPS device 301 can send the generated treatment plan to the control device, so that the control device 302 controls the low-energy accelerator and / or the ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan. In this way, the embodiment of the present application can support the design of a corresponding treatment plan according to the location depth of the target area, so as to use a low-energy accelerator and / or an ultra-low-energy accelerator that matches the target area to irradiate the target area, provide targeted treatment methods for different types of diseases, improve the application flexibility of the radiotherapy system, broaden the range of treatable diseases, effectively meet the needs of precision radiotherapy, and support the realization of precision radiotherapy.

[0098] In some embodiments, in order to facilitate the formulation of a treatment plan for the target object, in S102, the TPS device 301 can process the volume image of the target object through the treatment planning system to accurately locate the target area position, structure, boundary, morphology, distribution characteristics and other information of the target object. Furthermore, the TPS device 301 can determine the target area information of the target object. For example, the TPS device 301 can determine the center position of the target area of ​​the target object through centroid calculation or automatic segmentation algorithm, and further determine the distance between the center position of the target area of ​​the target object and the body surface of the target object as the position depth of the target area.

[0099] In some embodiments, in S103, the TPS device 301 can perform calculation superposition through the radiotherapy planning system to accurately determine the prescription dose information of the target area. Alternatively, the prescription dose information of the target area can also be manually set in the TPS device 301. The TPS device 301 can read the prescription dose information of the target area manually set when necessary.

[0100] In some embodiments, the TPS device 301 may also determine that the position of the target area of ​​the target object has changed based on the image information of the target area of ​​the target object during the treatment process in combination with the volume image of the target object. Further, in the case where the position of the target area of ​​the target object has changed, the irradiation dose of the accelerator and / or radiation therapy head involved in the irradiation in the treatment plan may be updated based on the position change information of the target area of ​​the target object.

[0101] In some embodiments, the TPS device 301 can be divided into functional modules according to the above-mentioned treatment plan generation method example. For example, each functional module can be divided corresponding to each function, or two or more functions can be integrated into one processing module. The above-mentioned integrated module can be implemented in the form of hardware or in the form of software functional modules. It should be noted that the division of modules in the embodiments of the present application is schematic and is only a logical function division. There may be other division methods in actual implementation.

[0102] For example, when the TPS device 301 is implemented in the form of a software function module, Figure 5 FIG. 4 is a schematic diagram showing the structure of a treatment plan generating device. The treatment plan generating device 40 can be applied to the TPS device 301 to implement any possible treatment plan generating method involved in the above-mentioned embodiments. Figure 5 As shown, the treatment plan generating device 40 may include: an acquisition unit 401 and a processing unit 402 .

[0103] The acquisition unit 401 is used to acquire a volumetric image of the target object. The processing unit 402 is used to determine the target area information of the target object based on the volumetric image, wherein the target area information includes the position depth of the target area. The position depth of the target area is used to indicate the distance of the position of the target area relative to the body surface of the target object. The acquisition unit 401 is also used to acquire the prescription dose information of the target area, wherein the prescription dose information includes the radiation dose of the target area in different regions. The processing unit 402 is also used to generate a treatment plan based on the target area information and the prescription dose information of the target area, so that the control device controls the low-energy accelerator and / or the ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan.

[0104] In some embodiments, the processing unit 402 is specifically used to: when the position depth of the target area is less than or equal to a preset depth threshold, generate a treatment plan according to the target area information and the prescription dose information of the target area, so that the control device controls the ultra-low energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan. Alternatively, when the position depth of the target area is greater than the preset depth threshold, generate a treatment plan according to the target area information and the prescription dose information of the target area, so that the control device controls the low energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan, or control the low energy accelerator and the ultra-low energy accelerator to simultaneously emit a beam to the target area of ​​the target object.

[0105] Control device:

[0106] In some embodiments, the control device 302 is used to perform the above Figure 3 The radiotherapy control method shown is used to control the radiotherapy device 303 to execute the treatment plan, that is, to control the low-energy accelerator and / or the ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan.

[0107] In some embodiments, after the TPS device 301 generates a treatment plan according to the target area information and the prescription dose information of the target area, it can send the generated treatment plan to the control device 302. Accordingly, the control device 302 can receive the treatment plan from the TPS device 301. Further, the control device 302 can parse the treatment plan, determine the target area information of the target object, the accelerator that needs to be activated, and the dose distribution information of the accelerator that needs to be activated, etc., so as to control the low-energy accelerator and / or the ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the parsed information.

[0108] In some embodiments, if it is necessary to enable an ultra-low energy accelerator to emit a beam to a target area of ​​the target object, the control device 302 may further set the energy of the ultra-low energy accelerator accordingly according to the energy indication information in the treatment plan.

[0109] In some embodiments, the control device 302 can be divided into functional modules according to the above-mentioned radiotherapy control method example. For example, each functional module can be divided corresponding to each function, or two or more functions can be integrated into one processing module. The above-mentioned integrated module can be implemented in the form of hardware or in the form of software functional modules. It should be noted that the division of modules in the embodiment of the present application is schematic and is only a logical function division. There may be other division methods in actual implementation.

[0110] For example, when the control device 302 is implemented in the form of a software function module, Figure 6 FIG. 5 shows a schematic diagram of the structure of a radiotherapy control device. The radiotherapy control device 50 can be applied to the control device 302 to implement any possible radiotherapy control method involved in the above embodiments. Figure 6 As shown, the radiotherapy control device 50 may include: an acquisition unit 501 and a control unit 502 .

[0111] The acquisition unit 501 is used to acquire a treatment plan, the treatment plan includes target area information of the target object, and the target area information includes the position depth of the target area. The position depth of the target area is used to indicate the distance between the position of the target area and the body surface of the target object. The control unit 502 is used to control the low-energy accelerator and / or the ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the position depth of the target area.

[0112] In some embodiments, the control unit 502 is specifically used to: when the position depth of the target area is less than or equal to a preset depth threshold, control the ultra-low energy accelerator to emit a beam to the target area of ​​the target object. Alternatively, when the position depth of the target area is greater than the preset depth threshold, control the low energy accelerator, or control the low energy accelerator and the ultra-low energy accelerator to simultaneously emit a beam to the target area of ​​the target object.

[0113] Radiotherapy equipment:

[0114] In some embodiments, the radiotherapy device 303 is used to emit a beam to a target area of ​​a target object, and specifically includes a low-energy accelerator and an ultra-low-energy accelerator, wherein the energy of the beam emitted by the low-energy accelerator is higher than the energy of the beam emitted by the ultra-low-energy accelerator.

[0115] In this way, considering that rays of different energies have different properties and are adapted to different radiotherapy depths, the radiotherapy equipment 303 can support radiotherapy using an energy-matched accelerator based on the location depth of the target area, and can take into account the treatment of superficial tumors and deep tumors, providing more refined treatment methods for different types of diseases, effectively meeting the needs of precision radiotherapy, and supporting the realization of precision radiotherapy.

[0116] In some embodiments, the energy of the ultra-low energy accelerator included in the radiotherapy equipment 303 is adjustable, and can support flexible adjustment of the energy of the output beam according to parameters such as the target depth and prescription dose of the target object, thereby effectively meeting different radiotherapy needs.

[0117] The energy range of ultra-low energy accelerator is 300kV-1250kV. For example, for the target area located on the surface of the skin, the energy of the ultra-low energy accelerator can be adjusted to 300kV or 400kV to effectively meet the dose requirements of such target area and reduce the radiation to the normal subcutaneous tissue. The depth of the target area is the distance between the target area and the body surface of the target object.

[0118] For another example, for subcutaneous targets that are close to the skin, the energy of the ultra-low energy accelerator can be adjusted to 1000kV or 1250kV to effectively meet the dose requirements of such targets while reducing radiation to surrounding normal tissues. In addition, in this case, once the energy of the ultra-low energy accelerator is adjusted, it may not change during the treatment process.

[0119] In some embodiments, the control device 302 may control the radiotherapy device 303 to set the energy of the ultra-low energy accelerator accordingly according to the control parameters indicated by the treatment plan.

[0120] In this way, compared with the method in the related art of using a single-energy accelerator to irradiate the target area at any position and depth, in the embodiment of the present application, an ultra-low-energy accelerator can be used to accumulate energy for the shallower target areas at the superficial periphery, which can effectively meet the target area dose requirements while reducing radiation to normal tissues, is more conducive to the treatment of superficial tumors, and has less toxic side effects on child patients. It can make up for the shortcomings of using only conventional 6MV accelerator irradiation and can effectively support the realization of precision radiotherapy.

[0121] In addition, the energy of the low-energy accelerator included in the radiotherapy equipment 303 is 6 MV. Based on this, when the target area is too deep and the ultra-low-energy accelerator cannot effectively meet the target area dose requirement, the low-energy accelerator with an energy of 6 MV can also be used for irradiation to meet such radiotherapy scenarios that require lower energy beams.

[0122] In some embodiments, the radiotherapy device 303 may further include: a rotatable annular frame. The low-energy accelerator and the ultra-low-energy accelerator are arranged on the rotatable annular frame. The irradiation isocenter of the low-energy accelerator and the irradiation isocenter of the ultra-low-energy accelerator are located in the same horizontal plane and focused on the same point. In this way, the radiotherapy device 303 can effectively improve the accuracy and precision of irradiation of the target area of ​​the target object during radiotherapy, and ensure the treatment effect during rotational irradiation at various angles.

[0123] In addition, the ultra-low energy accelerator is set on a rotatable ring-shaped frame, which can support TBI irradiation of superficial tumors and achieve high-quality treatment of superficial tumors.

[0124] In some embodiments, the radiotherapy device 303 may further include: a single-layer grating component. The single-layer grating component may be disposed on the beam-out side of the ultra-low energy accelerator to adjust the shape of the radiation field of the beam emitted by the ultra-low energy accelerator. In this way, the radiotherapy device 303 may support conformal irradiation of the target area of ​​the target object through a relatively simple structure, effectively supporting the realization of precision radiotherapy.

[0125] For example, the TPS device 301 can determine that the irradiation angle of the ultra-low energy accelerator is angle 1 when the rotatable annular gantry is in the rotation start position, and determine conformal field 1 based on the shape of the target area at angle 1. Further, the TPS device 301 can determine that the irradiation angle of the ultra-low energy accelerator is angle 2 after the rotatable annular gantry rotates a specific angle, and determine conformal field 2 based on the shape of the target area at angle 2. By analogy, the TPS device 301 can determine conformal field 1 corresponding to angle 1 of the ultra-low energy accelerator, conformal field 2 corresponding to angle 2, ..., conformal field N corresponding to angle N, and generate a treatment plan. Among them, the specific angle of each rotation of the rotatable annular gantry can be determined according to the shape and complexity of the target area, so that the target area receives a suitable dose at different angles. Furthermore, during radiotherapy of the target area of ​​the target object, the control device 302 can control the continuous rotation of the rotatable annular frame of the radiotherapy device 303 based on the treatment plan, and control the single-layer grating component to form a light-transmitting area matching the corresponding conformal field at each irradiation angle, and control the ultra-low energy accelerator to emit a beam to conformally irradiate the target area of ​​the target object to achieve precise radiotherapy.

[0126] In some embodiments, the radiotherapy device 303 may further include: a flat panel detector. The flat panel detector is disposed on a rotatable annular frame and is disposed opposite to the ultra-low energy accelerator. Based on this, the flat panel detector can receive the beam emitted by the ultra-low energy accelerator that passes through the target area of ​​the target object and generate image information of the target area of ​​the target object. The image information of the target area of ​​the target object can be used to reflect the position change of the target area of ​​the target object.

[0127] In this way, during the irradiation treatment of the target area of ​​the target object, the flat panel detector can be supported to receive the beam emitted by the ultra-low energy accelerator that passes through the target area of ​​the target object, and generate image information of the target area of ​​the target object. Furthermore, the control device 302 can control the single-layer grating component in the radiotherapy device 303 to achieve conformal irradiation of the target area of ​​the target object according to the bird's-eye view (BEV) field shape based on the image information of the target area of ​​the target object.

[0128] Furthermore, the radiotherapy device 303 can also generate image information of the target area of ​​the target object through a flat panel detector opposite to the ultra-low energy accelerator. In this way, the TPS device 301 can compare the image information of the target area of ​​the target object with the treatment plan to achieve accurate monitoring of the radiotherapy process. In addition, when there is a large deviation between the position of the identified target area and the irradiation isocenter indicated by the treatment plan, an interlock can be triggered to achieve timely suspension in abnormal situations, effectively protecting the normal tissue of the target object from loss.

[0129] Based on this, compared with the method of using a tube for image guidance, the ultra-low energy accelerator in the embodiment of the present application can be used as an image guidance device for image guidance and auxiliary treatment while assisting radiotherapy, so as to achieve real-time monitoring of the target area of ​​the target object during the treatment process without causing additional doses to the patient, thus achieving true real-time image guidance. In addition, the beam energy of the ultra-low energy accelerator of the present application can be flexibly adjusted, and can support the formulation of matching rays for different patients and different lesions, improve the image quality of the target area, and obtain more accurate and clear images.

[0130] Moreover, compared with the tube, the ultra-low energy accelerator has a longer service life, which can reduce the maintenance pressure and cost at the actual deployment site. Therefore, in the embodiment of the present application, the radiotherapy device 303 can generate a treatment beam through the ultra-low energy accelerator while generating a shadow guide beam, taking into account conformal irradiation and image information collection of the target area, and effectively supporting the realization of precision radiotherapy.

[0131] In some embodiments, the radiotherapy device 303 further includes: one or more radiation therapy heads. The irradiation isocenter of the low-energy accelerator, the irradiation isocenter of the ultra-low-energy accelerator, and the irradiation isocenter of one or more radiation therapy heads are located in the same horizontal plane and are focused on the same point. For example, the radiation therapy head can be a radiation source implemented by a gamma stereotactic system. In some embodiments, the radiation therapy head is provided with a cobalt radiation source.

[0132] In some embodiments, for a portion of the target area where the ultra-low energy accelerator or the low energy accelerator cannot effectively meet the dose requirement, the control device 302 may also control one or more radiation therapy heads to emit a beam to the target area of ​​the target object based on the treatment plan.

[0133] In some embodiments, for a target area with a larger dose requirement, the control device can also control the ultra-low energy accelerator and / or the low energy accelerator, and one or more radiation therapy heads to simultaneously emit beams to the target area of ​​the target object according to the control parameters indicated by the treatment plan.

[0134] Optionally, the radiation therapy head may use intensity-modulated radiation therapy (IMRT) or volumetric modulated arc therapy (VMAT) irradiation technology.

[0135] In some embodiments, when the ultra-low energy accelerator and the low energy accelerator simultaneously irradiate the target area of ​​the target object and still cannot effectively meet the target area dose requirement, the control device 302 can control the ultra-low energy accelerator, the low energy accelerator and one or more radiation therapy heads to simultaneously emit beams to the target area of ​​the target object based on the treatment plan to meet the target area dose requirement.

[0136] For example, Figure 7 As shown, it is a structural schematic diagram of a radiotherapy device 302 provided in an embodiment of the present application. Figure 7 The radiotherapy device 302 shown includes an ultra-low energy accelerator, a low energy accelerator, a flat panel detector, a radiation therapy head and a rotatable annular frame. The ultra-low energy accelerator, the low energy accelerator, the flat panel detector and a radiation therapy head are all arranged on the rotatable annular frame. In addition, the irradiation isocenter of the low energy accelerator, the irradiation isocenter of the ultra-low energy accelerator and the irradiation isocenter of the radiation therapy head are located in the same horizontal plane and are focused on the same point. The flat panel detector and the ultra-low energy accelerator are arranged relative to each other.

[0137] In some embodiments, the low energy accelerator may be a radiation therapy head with the same or similar beam energy. That is, the radiotherapy device 302 may include an ultra-low energy accelerator, one or more radiation therapy heads, a flat panel detector, and a rotatable annular gantry, but not a low energy accelerator.

[0138] For example, Figure 8 As shown, it is a structural schematic diagram of another radiotherapy device 302 provided in an embodiment of the present application. Figure 8 The radiotherapy device 302 shown includes an ultra-low energy accelerator, two radiation therapy heads, a flat panel detector and a rotatable annular frame. The ultra-low energy accelerator, the two radiation therapy heads and the flat panel detector are all arranged on the rotatable annular frame. In addition, the irradiation isocenter of the ultra-low energy accelerator and the irradiation isocenter of the two radiation therapy heads are located in the same horizontal plane and are focused on the same point. The flat panel detector and the ultra-low energy accelerator are arranged relative to each other.

[0139] In the electronic device of the fourth aspect of the present invention:

[0140] In the case of an integrated unit, Fig. 9Schematic diagram of the structure of an electronic device is shown. The electronic device 60 may be a treatment plan generating device to implement any possible treatment plan generating method involved in the above embodiments. Alternatively, the electronic device 60 may be a radiotherapy control device to implement any possible radiotherapy control method involved in the above embodiments. Fig. 9 As shown, the electronic device 60 may include: a processing module 601 and a communication module 602. The processing module 601 may be used to control and manage the actions of the electronic device 60. The communication module 602 may be used to support the communication between the electronic device 60 and other entities. Fig. 9 As shown, the electronic device 60 may further include a storage module 603 for storing program codes and data of the electronic device 60 .

[0141] The processing module 601 may be a processor or a controller. The communication module 602 may be a transceiver, a transceiver circuit or a communication interface, etc. The storage module 603 may be a memory.

[0142] When the processing module 601 is a processor, the communication module 602 is a transceiver, and the storage module 603 is a memory, the processor, the transceiver, and the memory may be connected via a bus.

[0143] In some embodiments, the electronic device 60 is used as a treatment plan generating device to implement any possible treatment plan generating method involved in the above embodiments. The electronic device 60 may include a TPS client and a TPS server. The TPS server may run a radiation therapy planning system (TPS). The radiation therapy planning system provides the functions of formulating, optimizing, and evaluating treatment plans.

[0144] The TPS client may be at least one of a smart phone, a smart watch, a desktop computer, a laptop, a virtual reality terminal, an augmented reality terminal, a wireless terminal, and a laptop computer. For example, in some embodiments, a user may trigger the TPS server to perform an adaptive treatment plan optimization process and display the optimized treatment plan through a radiotherapy planning system running on a TPS server through a TPS client. In this way, the user's time can be effectively saved, and the optimized treatment plan can be presented more intuitively so that the user can evaluate the treatment plan.

[0145] Among them, the TPS server can be an independent physical server, or a server cluster or distributed file system composed of multiple physical servers, or at least one of the cloud servers that provide basic cloud computing services such as cloud services, cloud databases, cloud computing, cloud functions, cloud storage, network services, cloud communications, middleware services, domain name services, security services, content distribution networks, and big data or artificial intelligence platforms, etc., which is not limited in the embodiments of the present disclosure. In some embodiments, the number of the above-mentioned TPS servers can be more or less, which is not limited in the embodiments of the present disclosure. Of course, the TPS server can also include other functions to provide more comprehensive and diversified services. In some embodiments, the TPS server is used to provide background services for the above-mentioned TPS client, such as executing an adaptive treatment plan optimization process.

[0146] In some embodiments, the electronic device 60 is used as a radiotherapy control device to implement any possible radiotherapy control method involved in the above embodiments. The electronic device 60 may include a host computer and a slave computer. The host computer is used to interact with the user, and the slave computer is used to control the movement of each moving part in the radiotherapy equipment 303. The host computer can be at least one of a smart phone, a smart watch, a desktop computer, a laptop, a virtual reality terminal, an augmented reality terminal, a wireless terminal, a laptop computer and other devices and / or a server device, and the slave computer can be a control device such as a programmable logic controller (PLC).

[0147] In the nonvolatile storage medium of the fifth aspect of the present invention:

[0148] The non-volatile storage medium stores a computer program, and when the computer program is read and executed, it implements any possible treatment plan generation method as in the above embodiments, or any possible radiotherapy control method as in the above embodiments.

[0149] In the computer program product of the fifth aspect of the present invention:

[0150] The computer program product includes computer instructions. When the computer instructions are executed on an electronic device, the electronic device executes any possible treatment plan generation method in the above embodiments, or any possible radiotherapy control method in the above embodiments.

[0151] In one embodiment, Fig.10 FIG. 2 shows a schematic diagram of the structure of another electronic device. Fig.10As shown, the electronic device 70 includes a computing unit 701, which can perform various appropriate actions and processes according to a computer program stored in a read-only memory (ROM) 702 or a computer program loaded from a storage unit 708 to a random access memory 703. In the random access memory (RAM) 703, various programs and data required for the operation of the electronic device 70 can also be stored. The computing unit 701, ROM 702 and RAM 703 are connected to each other via a bus 704. An input / output (I / O) interface 705 is also connected to the bus 704.

[0152] Multiple components in the electronic device 70 are connected to the input / output interface 705, including: an input unit 706, such as a keyboard, a mouse, etc.; an output unit 707, such as various types of displays, speakers, etc.; a storage unit 708, such as a disk, an optical disk, etc.; and a communication unit 709, such as a network card, a modem, a wireless communication transceiver, etc. The communication unit 709 allows the electronic device 70 to exchange information / data with other devices through a computer network such as the Internet and / or various telecommunication networks.

[0153] The computing unit 701 may be a variety of general and / or special processing components with processing and computing capabilities. Some examples of the computing unit 701 include, but are not limited to, a central processing unit, a graphics processing unit (GPU), various dedicated artificial intelligence (AI) computing chips, various computing units running machine learning model algorithms, digital signal processors, and any appropriate processors, controllers, microcontrollers, etc. The computing unit 701 performs the various methods and processes described above, such as a treatment plan generation method or a radiotherapy control method. For example, in one embodiment, the treatment plan generation method may be implemented as a computer software program, which is tangibly included in a machine-readable medium, such as a storage unit 708. For another example, in one embodiment, the radiotherapy control method may be implemented as a computer software program, which is tangibly included in a machine-readable medium, such as a storage unit 708.

[0154] In one embodiment, part or all of the computer program may be loaded and / or installed into the computer via ROM 702 and / or communication unit 709. Fig.10When the computer program is loaded into RAM 703 and executed by the computing unit 701, one or more steps of the treatment plan generation method described above may be executed, or one or more steps of the radiotherapy control method described above may be executed. Alternatively, in other embodiments, the computing unit 701 may be configured to execute the treatment plan generation method or the radiotherapy control method in any other appropriate manner (e.g., by means of firmware).

[0155] Various embodiments of the systems and techniques described above herein can be implemented in digital electronic circuit systems, integrated circuit systems, field programmable gate arrays, application specific integrated circuits, application specific standard parts (ASSP), system on chip systems (System On Chip, SOC), complex programmable logic devices (Complex Programmable Logic Device, CPLD), computer hardware, firmware, software, and / or combinations thereof. These various embodiments may include: being implemented in one or more computer programs, which can be executed and / or interpreted on a programmable system including at least one programmable processor, which can be a special purpose or general purpose programmable processor, which can receive data and instructions from a storage system, at least one input device, and at least one output device, and transmit data and instructions to the storage system, the at least one input device, and the at least one output device.

[0156] The program code for implementing the method of the present disclosure may be written in any combination of one or more programming languages. These program codes may be provided to a processor or controller of a general-purpose computer, a special-purpose computer, or other programmable data processing device, so that the program code, when executed by the processor or controller, enables the functions / operations specified in the flow chart and / or block diagram to be implemented. The program code may be executed entirely on the machine, partially on the machine, partially on the machine and partially on a remote machine as a stand-alone software package, or entirely on a remote machine or server.

[0157] In the context of the present disclosure, a machine-readable medium may be a tangible medium that may contain or store a program for use by or in conjunction with an instruction execution system, device, or equipment. A machine-readable medium may be a machine-readable signal medium or a machine-readable storage medium. A machine-readable medium may include, but is not limited to, an electronic, magnetic, optical, electromagnetic, infrared, or semiconductor system, device, or device, or any suitable combination of the foregoing. More specific examples of machine-readable storage media may include electrical connections based on one or more lines, portable computer disks, hard disks, random access memories, read-only memories, erasable programmable read-only memories, optical fibers, portable compact disk read-only memories, optical storage devices, magnetic storage devices, or any suitable combination of the foregoing.

[0158] To provide interaction with a user, the systems and techniques described herein can be implemented on a computer having: a display device for displaying information to the user, such as a cathode ray tube (CRT) or a liquid crystal display (LCD) monitor; and a keyboard and a pointing device (e.g., a mouse or a trackball), through which the user can provide input to the computer. Other types of devices can also be used to provide interaction with the user; for example, the feedback provided to the user can be any form of sensory feedback (e.g., visual feedback, auditory feedback, or tactile feedback); and the input from the user can be received in any form (including acoustic input, voice input, or tactile input).

[0159] The systems and techniques described herein can be implemented in a computing system that includes back-end components (e.g., as a data server), or a computing system that includes middleware components (e.g., an application server), or a computing system that includes front-end components (e.g., a user computer with a graphical user interface or a web browser through which a user can interact with implementations of the systems and techniques described herein), or a computing system that includes any combination of such back-end components, middleware components, or front-end components. The components of the system can be interconnected by any form or medium of digital data communication (e.g., a communication network). Examples of communication networks include: Local Area Networks (LANs), Wide Area Networks (WANs), and the Internet.

[0160] A computer system may include a client and a server. The client and the server are generally remote from each other and usually interact through a communication network. The relationship of client and server is generated by computer programs running on respective computers and having a client-server relationship with each other. The server may be a cloud server, a server of a distributed system, or a server combined with a blockchain.

[0161] It should be understood that in the various embodiments of the present application, the size of the serial numbers of the above-mentioned processes does not mean the order of execution. The execution order of each process should be determined by its function and internal logic, and should not constitute any limitation on the implementation process of the embodiments of the present application.

[0162] Those of ordinary skill in the art will appreciate that the units and algorithm steps of each example described in conjunction with the embodiments disclosed herein can be implemented in electronic hardware, or a combination of computer software and electronic hardware. Whether these functions are performed in hardware or software depends on the specific application and design constraints of the technical solution. Professional and technical personnel can use different methods to implement the described functions for each specific application, but such implementation should not be considered to be beyond the scope of this application.

[0163] Those skilled in the art can clearly understand that, for the convenience and brevity of description, the specific working processes of the systems, devices and units described above can refer to the corresponding processes in the aforementioned method embodiments and will not be repeated here.

[0164] The units described as separate components may or may not be physically separated, and the components shown as units may or may not be physical units, that is, they may be located in one place or distributed on multiple network units. Some or all of the units may be selected according to actual needs to achieve the purpose of the solution of this embodiment.

[0165] In the above embodiments, it can be implemented in whole or in part by software, hardware, firmware or any combination thereof. When implemented using a software program, it can be implemented in whole or in part in the form of a computer program product. The computer program product includes one or more computer instructions. When loading and executing computer program instructions on a computer, the process or function according to the embodiment of the present application is generated in whole or in part. The computer can be a general-purpose computer, a special-purpose computer, a computer network or other programmable devices. The computer instructions can be stored in a computer-readable storage medium, or transmitted from one computer-readable storage medium to another computer-readable storage medium, for example, the computer instructions can be transmitted from a website site, a computer, a server or a data center by wired (e.g., coaxial cable, optical fiber, digital subscriber terminal line (Digital Subscriber Line, DSL)) or wireless (e.g., infrared, wireless, microwave, etc.) mode to another website site, computer, server or data center. The computer-readable storage medium can be any available medium that a computer can access or a data storage device such as a server, a data center, etc. that contains one or more available media integrations. The available medium may be a magnetic medium (eg, a floppy disk, a hard disk, a magnetic tape), an optical medium (eg, a DVD), or a semiconductor medium (eg, a solid state disk (SSD)).

[0166] The above are only specific implementations of the present application, but the protection scope of the present application is not limited thereto. Any technician familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed in the present application, which should be included in the protection scope of the present application. Therefore, the protection scope of the present application should be based on the protection scope of the claims.

Claims

1. A treatment plan generation method, applied to a radiotherapy system, characterized in that: The radiotherapy system comprises: a low-energy accelerator and an ultra-low-energy accelerator; used to emit a beam to a target area of ​​a target object; the energy of the beam emitted by the low-energy accelerator is higher than the energy of the beam emitted by the ultra-low-energy accelerator; The treatment plan generating method comprises: Acquiring a volume image of the target object; Based on the volume image, determining target area information of the target object, the target area information including a position depth of the target area; the position depth of the target area is used to indicate a distance between the position of the target area and the body surface of the target object; Acquiring prescription dose information of the target area, wherein the prescription dose information includes radiation doses of target areas in different regions; A treatment plan is generated according to the target area information and the prescribed dose information of the target area, so that the control device controls the low-energy accelerator and / or the ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan.

2. The method for generating a treatment plan according to claim 1, characterized in that: The step of generating a treatment plan according to the target area information and the prescribed dose information of the target area so that the control device controls the low-energy accelerator and / or the ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan comprises: When the position depth of the target area is less than or equal to a preset depth threshold, generating a treatment plan according to the target area information and the prescription dose information of the target area, so that the control device controls the ultra-low energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan; Alternatively, when the position depth of the target area is greater than a preset depth threshold, a treatment plan is generated according to the target area information and the prescription dose information of the target area, so that the control device controls the low-energy accelerator to emit a beam to the target area of ​​the target object based on the treatment plan, or controls the low-energy accelerator and the ultra-low-energy accelerator to simultaneously emit a beam to the target area of ​​the target object.

3. A radiotherapy control method, applied to a radiotherapy system, characterized in that: The radiotherapy system comprises: a low-energy accelerator and an ultra-low-energy accelerator; used to emit a beam to a target area of ​​a target object; the energy of the beam emitted by the low-energy accelerator is higher than the energy of the beam emitted by the ultra-low-energy accelerator; The radiotherapy control method comprises: Acquire a treatment plan, wherein the treatment plan includes target area information of the target object, wherein the target area information includes a position depth of the target area; the position depth of the target area is used to indicate a distance between the position of the target area and the body surface of the target object; Based on the position depth of the target area, the low energy accelerator and / or the ultra low energy accelerator is controlled to emit a beam to the target area of ​​the target object.

4. The radiotherapy control method according to claim 3, characterized in that: The step of controlling the low-energy accelerator and / or the ultra-low-energy accelerator to emit a beam to the target area of ​​the target object based on the position depth of the target area comprises: When the position depth of the target area is less than or equal to a preset depth threshold, controlling the ultra-low energy accelerator to emit a beam to the target area of ​​the target object; Alternatively, when the position depth of the target area is greater than a preset depth threshold, the low-energy accelerator is controlled, or the low-energy accelerator and the ultra-low-energy accelerator are controlled to simultaneously emit a beam to the target area of ​​the target object.

5. A radiotherapy system, characterized in that: The radiotherapy system comprises: TPS device; used to execute the treatment plan generation method as claimed in claim 1 or 2; Control device; used to execute the radiotherapy control method as claimed in claim 3 or 4; Radiotherapy equipment; the radiotherapy equipment comprises: a low-energy accelerator and an ultra-low-energy accelerator; used to emit a beam to a target area of ​​a target object; the energy of the beam emitted by the low-energy accelerator is higher than the energy of the beam emitted by the ultra-low-energy accelerator.

6. The radiation therapy system according to claim 5, characterized in that The energy of the ultra-low energy accelerator is adjustable, and the energy range of the ultra-low energy accelerator is 300kV-1250kV; The energy of the low-energy accelerator is 6 MV.

7. The radiation therapy system according to claim 5, characterized in that The radiotherapy equipment also includes: a rotatable annular frame; the low-energy accelerator and the ultra-low-energy accelerator are arranged on the rotatable annular frame; the irradiation isocenter of the low-energy accelerator and the irradiation isocenter of the ultra-low-energy accelerator are located in the same horizontal plane and are focused on the same point.

8. The radiation therapy system according to claim 7, characterized in that The radiotherapy equipment also includes: A single-layer grating component; arranged at the beam-out side of the ultra-low energy accelerator, and used to adjust the shape of the radiation field of the beam emitted by the ultra-low energy accelerator; A flat panel detector is arranged on the rotatable annular frame and is arranged opposite to the ultra-low energy accelerator, and is used to receive the beam emitted by the ultra-low energy accelerator and passing through the target area of ​​the target object, and generate image information of the target area of ​​the target object, wherein the image information of the target area of ​​the target object is used to reflect the position change of the target area of ​​the target object.

9. The radiation therapy system according to claim 5, characterized in that The radiotherapy device also includes: one or more radiation therapy heads; The irradiation isocenter of the low-energy accelerator, the irradiation isocenter of the ultra-low-energy accelerator, and the irradiation isocenter of one or more radiation therapy heads are located in the same horizontal plane and are focused on the same point; The control device is further used to control one or more radiation therapy heads to simultaneously emit beams to a target area of ​​the target object based on the treatment plan.

10. An electronic device, characterized in that: The electronic device comprises: processor; a memory configured to store instructions executable by the processor; The processor is configured to execute the instructions to implement the treatment plan generation method as described in claim 1 or 2, or the radiotherapy control method as described in claim 3 or 4.

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