Candy composition, anti-aging tablet candy and preparation method of anti-aging tablet candy

Abstract

The invention relates to the technical field of functional candies, and particularly discloses a candy composition, an anti-aging tablet candy and a preparation method of the anti-aging tablet candy. The candy composition provided by the invention is prepared from the following components in parts by weight: 24 to 30 parts of natto powder, 0.3 to 0.6 part of astaxanthin microcapsule powder, 1 to 5 parts of radix notoginseng pollen, 0.02 to 0.1 part of nicotinamide and 14 to 20 parts of compound fruit and vegetable powder, the natto powder comprises natto powder I and natto powder II, the natto powder I is freeze-dried natto powder, the content of nattokinase is greater than or equal to 20000 cfu / g, and the natto powder II is a water extract of natto; the invention also provides an anti-aging tablet candy prepared from the candy composition. The anti-aging tablet candy provided by the invention has the advantages of being good in taste, low in cost, good in anti-aging effect and the like, and can meet the requirements of mass consumers.

Description

Technical Field

[0001] The present application relates to the technical field of functional candies, and in particular to a candy composition, anti-aging compressed candy and a preparation method thereof. Background Art

[0002] The anti-aging product market has developed rapidly in recent years, and consumers' demand for health and beauty has been growing. With the advancement of science and technology, various products with antioxidant and anti-aging functions have emerged, providing people with more choices. The development of these products not only meets market demand, but also promotes technological innovation and development in related industries. For example, research in the fields of functional foods, health products, and cosmetics has continued to deepen, bringing consumers more healthy choices.

[0003] In the field of anti-aging compressed candies, the anti-aging effect is currently mainly improved by adding ingredients such as vitamin C, vitamin E, collagen, hyaluronic acid, etc. In addition, some manufacturers enhance the antioxidant properties of their products by adding plant extracts such as green tea extract and grape seed extract. However, existing anti-aging compressed candies have defects such as high cost and unclear efficacy, and cannot meet the high expectations of consumers.

[0004] Therefore, there is an urgent need to develop a low-cost, anti-aging effect of compressed candy to meet the needs of mass consumers. Summary of the invention

[0005] In order to overcome the defects of existing compressed candies such as high cost and unclear efficacy, the present application provides a candy composition, an anti-aging compressed candy and a preparation method thereof.

[0006] In a first aspect, the present application provides a candy composition, which adopts the following technical solution: A candy composition, comprising the following components in parts by weight: 24-30 parts of natto powder, 0.3-0.6 parts of astaxanthin microcapsule powder, 1-5 parts of Panax notoginseng pollen, 0.02-0.1 parts of nicotinamide, and 14-20 parts of composite fruit and vegetable powder; The natto powder comprises natto powder I and natto powder II, wherein the natto powder I is natto freeze-dried powder with a nattokinase content of ≥20000 cfu / g, and the natto powder II is a water extract of natto.

[0007] This application uses natto powder, astaxanthin microcapsule powder and Panax notoginseng pollen to prepare a candy composition. The compressed candy prepared by the above candy composition not only has good taste and low cost, but also can promote cell autophagy, remove senescent cells, and achieve anti-aging effects. Among them, natto powder is rich in spermidine, pyrroloquinoline quinone disodium salt and natto-kinase and other substances. Spermidine can promote cell and mitochondrial autophagy, thereby delaying the process of cell aging; pyrroloquinoline quinone disodium salt has good antioxidant properties, supports the growth of living cells under stress and plays a good protective role; nattokinase can be decomposed into amino acid fragments or peptide chains with smaller molecular weight by intestinal digestive juice, achieving anti-thrombotic, blood pressure lowering, neuroprotection, anti-atherosclerosis and other effects, thereby delaying aging. Astaxanthin microcapsule powder has good antioxidant capacity on the one hand, can improve the oxidation and aging degree of the nervous system, and on the other hand, can regulate cell autophagy, and has a good anti-aging effect. Panax notoginseng pollen is rich in active ingredients such as ginsenosides and notoginseng saponins, has obvious anti-inflammatory and antioxidant effects, reduces cell mortality, and enhances anti-aging effects. Nicotinamide, as the amide form of vitamin B3, can participate in the oxidation-reduction reaction in the body, intervene in physiological processes such as energy metabolism, and play an important role in maintaining the normal life activities of cells. The various vitamins and minerals in the composite fruit and vegetable powder can not only supplement the nutrients required by the human body, but also work together with other ingredients to play an anti-aging effect. In general, the candy composition provided by the present application achieves a balance between cost and efficacy through reasonable compatibility, and the anti-aging tablet candy prepared using it can regulate the aging process of the body in a variety of ways, thereby achieving the purpose of anti-aging and meeting the needs of consumers for anti-aging products.

[0008] In some embodiments, the weight portions of the natto powder may be 24-26 parts, 24-28 parts, 24-30 parts, 26-28 parts, 26-30 parts, or 28-30 parts.

[0009] In a specific embodiment, the weight portion of the natto powder can also be 24 parts, 26 parts, 28 parts or 30 parts.

[0010] In some embodiments, the weight portion of the astaxanthin microcapsule powder may be 0.3-0.4, 0.3-0.5, 0.3-0.6, 0.4-0.5, 0.4-0.6 or 0.5-0.6.

[0011] In a specific embodiment, the weight portion of the astaxanthin microcapsule powder can also be 0.3 parts, 0.4 parts, 0.5 parts or 0.6 parts.

[0012] In some embodiments, the weight proportion of Panax notoginseng pollen can be 1-2 parts, 1-3 parts, 1-4 parts, 1-5 parts, 2-3 parts, 2-4 parts, 2-5 parts, 3-4 parts, 3-5 parts or 4-5 parts.

[0013] In a specific embodiment, the weight portion of Panax notoginseng pollen can also be 1 part, 2 parts, 3 parts, 4 parts Or 5 servings.

[0014] In some embodiments, the weight portion of niacinamide can be 0.02-0.04, 0.02-0.06, 0.02-0.08, 0.02-0.1, 0.04-0.06, 0.04-0.08, 0.04-0.1, 0.06-0.08, 0.06-0.1, or 0.08-0.1.

[0015] In a specific embodiment, the weight portion of niacinamide can also be 0.02 parts, 0.04 parts, 0.06 parts, 0.08 parts or 0.1 parts.

[0016] Optionally, the candy composition comprises the following components in parts by weight: 26-28 parts of natto powder, 0.4-0.5 parts of astaxanthin microcapsule powder, 2-4 parts of Panax notoginseng pollen, 0.04-0.08 parts of nicotinamide, and 14-20 parts of compound fruit and vegetable powder.

[0017] In the present application, the addition amount of natto powder, astaxanthin microcapsule powder, Panax notoginseng pollen and nicotinamide will affect the anti-aging effect of anti-aging compressed candies. The present application finds through nematode aging test and life span detection test that by controlling the weight portions of natto powder, astaxanthin microcapsule powder, Panax notoginseng pollen and nicotinamide within the above range, the anti-aging effect of the obtained anti-aging compressed candies is better; the intervention culture medium prepared by the above anti-aging compressed candies is used to intervene and culture nematodes for 8 days, and the lipofuscin accumulation level of the nematodes is reduced by more than 20%, and the life span is longer.

[0018] Optionally, the candy composition comprises the following components in parts by weight: 28 parts of natto powder, 0.5 parts of astaxanthin microcapsule powder, 3 parts of Panax notoginseng pollen, 0.06 parts of nicotinamide, and 16 parts of compound fruit and vegetable powder.

[0019] Optionally, the weight ratio of the natto powder I to the natto powder II is (4-6):1.

[0020] In a specific embodiment, the weight ratio of the natto powder I to the natto powder II is 5:1.

[0021] Optionally, the composite fruit and vegetable powder is a mixture of hawthorn powder and lime powder.

[0022] Optionally, the weight ratio of the hawthorn powder to the lime powder is (1.8-2.3):1.

[0023] Optionally, the candy composition further comprises 30-40 parts of sorbitol, 1-3 parts of microcrystalline cellulose, and 1-3 parts of magnesium stearate.

[0024] In a second aspect, the present application provides an anti-aging compressed candy, which is prepared using the candy composition.

[0025] Optionally, the anti-aging compressed candy has a tablet weight of 0.50-0.54 g, a hardness of 110-130 N, and a brittleness of <0.5%.

[0026] In a third aspect, the present application provides a method for preparing an anti-aging compressed candy, comprising the following steps: first, mixing natto powder, astaxanthin microcapsule powder, Panax notoginseng pollen, niacinamide, compound fruit and vegetable powder, sorbitol and microcrystalline cellulose at a rotation speed of 30-40 Hz for 10-20 minutes, then adding magnesium stearate, mixing at a rotation speed of 30-40 Hz for 10-20 minutes, and then pressing and molding to obtain an anti-aging compressed candy.

[0027] In summary, this application has the following beneficial effects: 1. This application uses natto powder, astaxanthin microcapsule powder and Panax notoginseng pollen to prepare an anti-aging compressed candy, which not only has a good taste and low cost, but also can promote cell autophagy, help repair damaged cells, eliminate toxic proteins related to various neurogenic diseases in the body, improve the body's oxidative stress state, and thus delay aging.

[0028] 2. Through experimental research, the present application found that by further controlling the weight proportions of natto powder, astaxanthin microcapsule powder, Panax notoginseng pollen and nicotinamide within the following range: 26-28 parts of natto powder, 0.4-0.5 parts of astaxanthin microcapsule powder, 2-4 parts of Panax notoginseng pollen and 0.04-0.08 parts of nicotinamide, the anti-aging effect of the obtained anti-aging compressed sugar tablets is better. DETAILED DESCRIPTION

[0029] The present application provides a candy composition, comprising the following components in parts by weight: 24-30 parts of natto powder, 0.3-0.6 parts of astaxanthin microcapsule powder, 1-5 parts of Panax notoginseng pollen, 0.02-0.1 parts of nicotinamide, 14-20 parts of composite fruit and vegetable powder, 30-40 parts of sorbitol, 1-3 parts of microcrystalline cellulose and 1-3 parts of magnesium stearate. Further, the candy composition comprises the following components in parts by weight: 26-28 parts of natto powder, 0.4-0.5 parts of astaxanthin microcapsule powder, 2-4 parts of Panax notoginseng pollen, 0.04-0.08 parts of nicotinamide, and 14-20 parts of composite fruit and vegetable powder. Wherein, the composite fruit and vegetable powder is a mixture of hawthorn powder and lime powder; the weight ratio of natto powder I and natto powder II is (4-6):1; further, the weight ratio of hawthorn powder and lime powder is (1.8-2.3):1.

[0030] The present application provides an anti-aging compressed candy, and the preparation method thereof comprises the following steps: firstly, natto powder, astaxanthin microcapsule powder, Panax notoginseng pollen, nicotinamide, compound fruit and vegetable powder, sorbitol and microcrystalline cellulose are mixed at a rotation speed of 30-40 Hz for 10-20 minutes, then magnesium stearate is added, and after mixing at a rotation speed of 30-40 Hz for 10-20 minutes, the mixture is pressed and formed to obtain the anti-aging compressed candy.

[0031] In this application, natto powder I is natto freeze-dried powder, nattokinase activity ≥ 20000 cfu / g, purchased from Xi'an Zhengdong Biotechnology Co., Ltd.; natto powder II is a water extract of natto, purchased from Xi'an An'ao Biotechnology Co., Ltd.; astaxanthin microcapsule powder is Haematococcus pluvialis astaxanthin microcapsule powder, purchased from Yunnan Alcon Biotechnology Co., Ltd.; Panax notoginseng pollen is purchased from Xi'an An'ao Biotechnology Co., Ltd.; nicotinamide is purchased from Tianjin Zhongrui Pharmaceutical Co., Ltd.; hawthorn powder and lime powder are both 40 mesh, both purchased from Qingdao Boen High-tech Biotechnology Co., Ltd.; sorbitol is purchased from Shandong Lujian Biotechnology Co., Ltd.; microcrystalline cellulose is purchased from Shandong Liujia Pharmaceutical Excipients Co., Ltd.; magnesium stearate is purchased from Qufu Pharmaceutical Excipients Co., Ltd. The raw materials, reagents, solvents, etc. used in this application can all be obtained commercially.

[0032] The present application is further described in detail below in conjunction with embodiments and performance testing experiments.

[0033] Examples 1-15 Examples 1-15 each provide an anti-aging compressed candy.

[0034] The difference between the above embodiments is that the addition amount of each component in the anti-aging compressed candy is specifically shown in Table 1 below.

[0035] The preparation method of the anti-aging compressed candy provided in Example 1-15 is as follows: 16 g of natto powder (the weight ratio of natto powder I and natto powder II is 5:1), astaxanthin microcapsule powder, Panax notoginseng pollen, niacinamide, composite fruit and vegetable powder (hawthorn powder and lime powder in a weight ratio of 2:1), 30 g of sorbitol, and 2 g of microcrystalline cellulose are weighed respectively, mixed at a speed of 35 Hz for 15 min, then 2 g of magnesium stearate is added, and mixing is continued at a speed of 35 Hz for 15 min. After compression molding, an anti-aging compressed candy with a tablet weight of 0.52±2 g is obtained.

[0036] Table 1 Addition amount of each component in the anti-aging tablet candies of Examples 1-15 Comparative Example 1 Comparative Example 1 provides an anti-aging compressed candy.

[0037] The difference between the comparative example and Example 3 is that the amount of natto powder added to the anti-aging compressed candy is 0.

[0038] Comparative Example 2 Comparative Example 2 provides an anti-aging compressed candy.

[0039] The difference between the comparative example and Example 3 is that the amount of astaxanthin microcapsule powder added to the anti-aging compressed candy is 0.

[0040] Comparative Example 3 Comparative Example 3 provides an anti-aging compressed candy.

[0041] The difference between the comparative example and Example 3 is that the amount of Panax notoginseng pollen added to the anti-aging compressed candy is 0.

[0042] Comparative Example 4 Comparative Example 4 provides an anti-aging compressed candy.

[0043] The difference between the comparative example and Example 3 is that the amount of nicotinamide added to the anti-aging compressed candy is 0.

[0044] Hardness testing The hardness and brittleness of the anti-aging compressed candies provided in Examples 1-15 and Comparative Examples 1-4 were tested, and the results are shown in Table 2 below.

[0045] (1) Hardness: The hardness of the anti-aging compressed candies was tested using a tablet friability hardness tester CJY-2C (Shanghai Huanghai Drug Testing Instrument Co., Ltd.); 10 tablets were tested in parallel in each group and the average value was taken; (2) Friability: The friability of compressed candy products was tested using a tablet friability and hardness tester CJY-2C (Shanghai Huanghai Drug Testing Instrument Co., Ltd.).

[0046] Table 2 Test results of hardness and brittleness of anti-aging tablet candies provided by Examples 1-15 and Comparative Examples 1-4 According to the test results in Table 2, the hardness of the anti-aging compressed candy prepared in the present application is 118-123N, and the brittleness is less than 0.5%, which means that the anti-aging compressed candy has a moderate hardness and is not easy to break, and can meet the use needs of consumers.

[0047] Nematode aging test and life span test (I) Nematode aging test (1) Select N2 wild-type Caenorhabditis elegans (purchased from Beijing Crespo Biotechnology Co., Ltd.), wash the nematodes with ice-cold M9 buffer, let it stand at 4°C for 20 minutes, and discard the supernatant; then resuspend the precipitate with M9 buffer, let it stand at 4°C for another 20 minutes, and discard the supernatant; inoculate the precipitate in NGM medium coated with Escherichia coli OP50, and culture it continuously in a 16°C biochemical incubator for 48 hours; then transfer the nematodes to the intervention culture medium for intervention culture, replace the intervention culture medium every 2 days on average, and continue the intervention culture for 8 days; use the nematodes cultured in NGM medium coated with Escherichia coli OP50 as the control group; The formula of NGM medium is: peptone 2.5 g / L, sodium chloride 3.0 g / L, calcium chloride 0.111 g / L, magnesium sulfate 0.12 g / L, cholesterol 0.005 g / L, potassium dihydrogen phosphate 3.4 g / L, agar 17.0 g / L, pH value adjusted to 7.2 ± 0.2, the balance is water; Intervention culture medium: The anti-aging compressed candies of Examples 1-15 and Comparative Examples 1-4 were crushed respectively, and then added to NGM culture medium coated with Escherichia coli OP50 in an amount of 1 g / L to obtain intervention culture medium A1-A15 and intervention culture medium B1-B4, respectively.

[0048] (2) After the experiment, 100 mM sodium azide was used to anesthetize the nematodes after 8 days of intervention, and the nematodes were transferred to a glass slide; then an inverted fluorescence microscope was used with fixed exposure time and intensity, with the excitation wavelength set to 358 nm and the emission wavelength set to 430 nm to observe the fluorescence intensity of lipofuscin in the nematodes, and fluorescent images were taken. The fluorescence intensity was quantitatively analyzed using Image J software, and the lipofuscin accumulation level was displayed as the fluorescence intensity value. The reduction in the lipofuscin accumulation level of the nematodes in each intervention culture medium relative to the lipofuscin accumulation level of the nematodes in the NGM culture medium was calculated to characterize the degree of aging of the nematodes. The calculation method for the reduction in the lipofuscin accumulation level is as follows: The amount of reduction in lipofuscin accumulation level = (lipofuscin accumulation level of nematodes in NGM culture medium - lipofuscin accumulation level of nematodes in intervention culture medium) / lipofuscin accumulation level of nematodes in NGM culture medium × 100%; The reduction in lipofuscin accumulation levels of nematodes in each intervention culture medium is shown in Table 3 below.

[0049] Note: As the aging process of nematodes progresses, lipofuscin will gradually accumulate in its intestine, and autofluorescence is an effective biomarker of nematode aging. Under a fluorescence microscope, spontaneous blue fluorescence of lipofuscin in the intestine of nematodes can be seen, and the fluorescence intensity is directly proportional to the amount of lipofuscin accumulated.

[0050] (II) Nematode life span detection (1) Select N2 wild-type Caenorhabditis elegans (Strain Collection Center of Food Biotechnology Center, Jiangnan University), and culture the nematodes in NGM medium for 48 hours; then transfer the nematodes to intervention medium for intervention culture, and change the intervention medium every 2 days on average; the nematodes cultured in NGM medium were used as the control group; (2) During the intervention culture period, the survival rate of nematodes in each intervention culture medium was recorded daily until all nematodes died; the survival rates of nematodes on days 10, 20, 30, 35, and 40 are shown in Table 3 below.

[0051] Table 3 Aging and lifespan test results of nematodes in each intervention medium According to the test results in Table 3, the intervention culture medium A1-A15 containing the anti-aging compressed candies provided in Examples 1-15 of the present application was used to culture nematodes for 8 days, and the lipofuscin accumulation level of the nematodes was reduced by 17.6-25.8%; while the intervention culture medium B1-4 made of the anti-aging compressed candies provided in Comparative Examples 1-4 was used to culture nematodes for 8 days, and the lipofuscin accumulation level of the nematodes was reduced by 9.6-15.2%; and the life span detection test found that the survival rate of the nematodes in the intervention culture medium A1-A15 was still maintained at 50% or above on the 30th day, while the survival rate of the nematodes in the intervention culture medium B1-B4 was only 10-45% (<50%) on the 30th day, and the 35th day was almost dead. Therefore, it is shown that the anti-aging compressed candies provided in Examples 1-15 of the present application can remove senescent cells, reduce lipofuscin accumulation, and achieve a good anti-aging effect.

[0052] Further comparison revealed that after 8 days of intervention culture of nematodes in intervention culture medium A2-A3, A6, A9-A10, A13-A14, the lipofuscin accumulation level of nematodes decreased by 21.3-25.8% (≥20.0%); while after 8 days of intervention culture of nematodes in intervention culture medium A1, A4-5, A7-8, and A11, the lipofuscin accumulation level of nematodes decreased by 17.6-19.8% (<20.0%); and the lifespan detection experiment found that some nematodes in intervention culture medium A2-A3, A6, A9-A10, A13-A14 were still partially alive on the 40th day; while the nematodes in intervention culture medium A1, A4-5, A7-8, A11-12, and A15 were all dead on the 40th day. Therefore, it is explained that the present application further controls the weight proportions of natto powder, astaxanthin microcapsule powder and Panax notoginseng pollen within the following range: 26-28 parts of natto powder, 0.4-0.5 parts of astaxanthin microcapsule powder, 2-4 parts of Panax notoginseng pollen and 0.04-0.08 parts of niacinamide, and the obtained anti-aging compressed sugar has better anti-aging effect.

[0053] Although the present invention has been described in detail above with general descriptions and specific embodiments, it is obvious to those skilled in the art that some modifications or improvements may be made thereto based on the present invention. Therefore, these modifications or improvements made without departing from the spirit of the present invention all fall within the scope of protection claimed by the present invention.

Claims

1. A candy composition, characterized in that: The invention comprises the following components in parts by weight: 24-30 parts of natto powder, 0.3-0.6 parts of astaxanthin microcapsule powder, 1-5 parts of Panax notoginseng pollen, 0.02-0.1 parts of nicotinamide, and 14-20 parts of compound fruit and vegetable powder; The natto powder comprises natto powder I and natto powder II, wherein the natto powder I is natto freeze-dried powder with a nattokinase content of ≥20000 cfu / g, and the natto powder II is a water extract of natto.

2. The candy composition according to claim 1, characterized in that The candy composition comprises the following components in parts by weight: 26-28 parts of natto powder, 0.4-0.5 parts of astaxanthin microcapsule powder, 2-4 parts of Panax notoginseng pollen, 0.04-0.08 parts of nicotinamide, and 14-20 parts of composite fruit and vegetable powder.

3. The candy composition according to claim 1, characterized in that The candy composition comprises the following components in parts by weight: 28 parts of natto powder, 0.5 parts of astaxanthin microcapsule powder, 3 parts of Panax notoginseng pollen, 0.06 parts of nicotinamide, and 16 parts of compound fruit and vegetable powder.

4. The candy composition according to claim 1, characterized in that: The weight ratio of the natto powder I to the natto powder II is (4-6):

1.

5. The candy composition according to claim 1, characterized in that: The composite fruit and vegetable powder is a mixture of hawthorn powder and lime powder.

6. The candy composition according to claim 1, characterized in that: The weight ratio of the hawthorn powder to the lime powder is (1.8-2.3):

1.

7. The candy composition according to any one of claims 1 to 6, characterized in that The candy composition further comprises 30-40 parts of sorbitol, 1-3 parts of microcrystalline cellulose and 1-3 parts of magnesium stearate.

8. An anti-aging compressed candy, characterized in that: The candy composition is prepared using the candy composition described in any one of claims 1 to 7.

9. The anti-aging compressed candy according to claim 8, characterized in that: The anti-aging compressed candy has a tablet weight of 0.50-0.54 g, a hardness of 110-130 N, and a brittleness of <0.5%.

10. The method for preparing the anti-aging compressed candy according to claim 8 or 9, characterized in that: The following steps are involved: First, natto powder, astaxanthin microcapsule powder, Panax notoginseng pollen, niacinamide, compound fruit and vegetable powder, sorbitol and microcrystalline cellulose are mixed at a rotation speed of 30-40 Hz for 10-20 minutes, and then magnesium stearate is added, mixed at a rotation speed of 30-40 Hz for 10-20 minutes, and then pressed into shape.

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