Composition containing wheat germ extract and application thereof

Abstract

The invention discloses a composition containing a wheat germ extract and application of the composition in improvement of female perimenopausal symptoms. The composition of the wheat germ extract is prepared from the following raw material components: a Chinese date extract, a wheat germ extract, a ginseng extract and pyrroloquinoline quinone disodium salt. The composition containing the wheat germ extract takes Chinese dates and ginseng as raw materials, is safe and convenient to eat, and can relieve and improve the symptoms of female endocrine disorder, mood anxiety and irritability when applied to female perimenopause.

Description

Technical Field

[0001] The invention relates to the technical field of health food processing, and in particular to a composition containing wheat germ extract and application thereof in improving perimenopausal symptoms in women. Background Art

[0002] In reality, many people think that menopause refers to menopause. In fact, these are two completely different medical concepts. Menopause is a transition period from the beginning of female ovarian function decline to complete loss. During this period, the menstrual cycle is irregular, the mood fluctuates greatly, and it is easy to have anxiety and depression, and it is difficult to control oneself. Menopause refers to the cessation of menstruation. Before menopause, the ovaries have been gradually declining. This stage is called the menopausal transition period. After menopause, the ovarian function is even lower, but it does not necessarily disappear immediately. It usually takes 2-5 years, or even longer. Therefore, menopause is the sum of the menopausal transition period, menopause and postmenopause. Some scholars call it "perimenopause". During the perimenopause, ovarian function begins to decline, endocrine disorders or reductions occur, resulting in large changes in hormone levels in the body and imbalances in the autonomic nervous system, which triggers systemic changes in the vascular system, musculoskeletal system, urogenital system, and cranial nerves. It is accompanied by a variety of diseases, including but not limited to vasomotor and psychological symptoms such as facial flushing, night sweats, sleep disorders, fatigue, depression, anxiety, attention disorders, memory disorders, loss of skin elasticity due to collagen reduction, sagging breasts, and dementia. There is a high probability that menopausal symptoms, together with physical aging, will turn into chronic diseases.

[0003] The research of the Stanford University team in the United States also pointed out that people do not age slowly at a uniform speed, but will experience a cliff-like state change at the age of 34, 60, and 70. In addition to the influence of external factors, the cliff-like aging is mainly due to the sharp decline in estrogen levels in the body, which leads to a decrease in physical function. In addition, the current social competition is fierce, the pressure of life is increasing, and the psychological burden of women has greatly increased, coupled with bad living habits and eating habits. At present, there are many drugs on the market to treat or relieve women's menopausal symptoms, but Western medical treatment drugs usually have certain side effects and are not suitable for long-term use; at the same time, Chinese medicine conditioning and nourishment also mostly appear in the form of medicine, and most of the Chinese herbal medicine ingredients are not suitable for long-term consumption. There are few dietary products suitable for long-term consumption and auxiliary treatment, so it is very practical to research and develop a safe auxiliary treatment dietary product. Summary of the invention

[0004] The purpose of the present invention is to provide a composition containing wheat germ extract. The composition containing wheat germ extract uses jujube and ginseng as raw materials, is safe and convenient to eat, and is applied to perimenopausal women to relieve and improve the symptoms of endocrine disorders, emotional anxiety and irritability in women.

[0005] To achieve the above object, the present invention adopts the following technical solutions:

[0006] A composition containing wheat germ extract, wherein the raw material composition ratio of the composition containing wheat germ extract is as follows: 1800-3000 parts of jujube extract, 500-850 parts of wheat germ extract, 200-300 parts of ginseng extract, and 3-10 parts of pyrroloquinoline quinone disodium salt.

[0007] Preferably, the composition containing wheat germ extract has the following raw material composition ratios by weight: 2200-2800 parts of jujube extract, 700-800 parts of wheat germ extract, 180-250 parts of ginseng extract, and 4-8 parts of pyrroloquinoline quinone disodium salt.

[0008] Preferably, the composition containing wheat germ extract has the following raw material composition ratios by weight: 2500 parts of jujube extract, 750 parts of wheat germ extract, 200 parts of ginseng extract, and 5 parts of pyrroloquinoline quinone disodium salt.

[0009] Preferably, the preparation method of the jujube extract is: wash the jujube, slice and crush it, soak and cook it to obtain a slurry, extract the slurry in water and / or ethanol, filter and purify it, evaporate and dry it to obtain the jujube extract.

[0010] Preferably, the preparation method of the ginseng extract is: wash the ginseng to remove impurities such as dirt and sand, slice and crush, add an appropriate amount of water and / or ethanol to the ginseng slices or powder to extract to obtain a ginseng extract, filter the ginseng extract, concentrate and dry to obtain the ginseng extract.

[0011] Preferably, the preparation method of the wheat germ extract is: grinding and washing the cleaned and hulled wheat to separate the germ from the wheat, softening and extracting the germ, extracting with water and / or ethanol to obtain a wheat germ extract, and concentrating and drying the wheat germ extract to obtain a wheat germ extract.

[0012] The application of the composition containing wheat germ extract in the above technical solution in products for alleviating premature ovarian failure and menopausal symptoms in women.

[0013] A health food, comprising the composition containing wheat germ extract as described in the above technical solution and auxiliary materials or additives allowed to be used in health foods.

[0014] Preferably, the auxiliary material is any one or any combination of wolfberry, Poria cocos, raspberry, sea buckthorn, peach kernel, γ-aminobutyric acid, vitamin E, vitamin D3, and folic acid.

[0015] Preferably, the health food is a granule, oral liquid, tablet or capsule.

[0016] The beneficial effects of the present invention are:

[0017] The ginseng and jujube contained in this application are foods that are both medicinal and edible. Jujube itself has the effects of tonifying the spleen and stomach, replenishing qi and promoting the production of body fluid, treating weak stomach and poor appetite, insufficient qi, blood and body fluid, palpitations, and women's irritability. Ginseng has the effects of greatly replenishing vital energy, restoring pulse and strengthening deficiency, tonifying spleen and lung, promoting the production of body fluid and nourishing blood, and calming the mind and improving intelligence. Jujube, ginseng and wheat germ extracts are used in this application, supplemented by pyrroloquinoline quinone disodium salt, and the principle of traditional Chinese medicine consolidation is combined with the symptom cause principle of Western medicine to give full play to the pharmacological effects of Chinese herbal medicine, thereby achieving the effect of improving female ovarian function. The composition in the present invention has a rigorous formula, simple medicinal taste, no toxic side effects, can be taken for a long time, regulates the body, and has a significant effect in treating female menopausal syndrome.

[0018] Wheat germ extract is rich in spermidine, which is a polycationic (-NH3+) fatty amine small molecule. As an intermediate molecule in the metabolic process, it can activate the autophagy of cells, remove excess free radicals in the body, reduce the number of damaged mitochondria through mitochondrial autophagy, promote the lysis of aging cells, and promote the biosynthesis of nucleic acids and proteins, generate new cells, and thus delay the aging of the body; and pyrroloquinoline quinone disodium salt has a strong peroxide scavenging ability and can protect mitochondria from oxidative damage. In addition, spermidine is a key metabolite for maintaining the reproductive lifespan of female animals. It can improve and promote the recovery of ovarian function and maintain a certain state of hormone secretion. It can also promote the activation of human skin and is the driving force for the skin to maintain its delicate luster. As a growth factor, pyrroloquinoline quinone disodium salt can maintain the content of skin collagen and avoid cross-linking damage of elastin.

[0019] Jujube is sweet, flat, and warm to replenish the spleen meridian deficiency, sweet to slow down the Yin blood, and harmonize Yin and Yang, regulate Ying and Wei, produce body fluids, replenish the middle and replenish Qi, moisten the heart and lungs, and treat Yin deficiency. In particular, cyclic adenosine monophosphate in jujube extract is an important substance involved in regulating material metabolism and biological functions in cells. It can regulate neurotransmitter synthesis, promote hormone secretion, and stimulate the hematopoietic function of bone marrow stem cells, which has the effect of replenishing blood.

[0020] Ginseng is a plant of the Araliaceae family. It tastes sweet, slightly bitter, and slightly warm. It enters the spleen, lung, heart, and kidney meridians. It can promote the production of body fluids and nourish blood, help the lung qi and promote blood circulation, restore the pulse and strengthen the body, nourish the spleen and lungs, and calm the mind and improve intelligence. Ginseng extract contains a large amount of ginsenosides. Ginsenosides are a natural antioxidant sterol compound that can clean up free radicals in the human body that damage human cells and prevent the generation of free radicals. It can increase the activity of human tissue cells and prevent cell damage, thereby improving memory, delaying aging symptoms, and allowing the human body to maintain a normal and youthful state.

[0021] After the composition in the present application enters the human body and is absorbed, spermidine in the wheat germ extract will bind to the target protein to stimulate the mechanism of human cell autophagy. Compared with men, spermidine has a clearer target for the female reproductive system, especially promoting the development of oocytes. At the same time, cyclic adenosine monophosphate in the jujube extract stimulates the hematopoietic function of bone marrow stem cells and the secretion of hormones, improves the decline of ovarian function, maintains endocrine stability, and alleviates various symptoms caused by the cliff-like drop in hormone levels in the body. Pyrroloquinoline quinone disodium salt protects mitochondria from oxidative damage, further strengthens spermidine-activated cells, supports mitochondria to convert food and oxygen into energy, and maintains cell vitality. At the same time, ginsenosides strengthen the body's inherent volume and enhance the energy source of mitochondria, thereby relieving women's menopausal anxiety, irritability, dull skin and other symptoms caused by endocrine disorders and large changes in hormone levels in the body.

[0022] In addition, the glutathione contained in wheat germ also has anti-oxidation and anti-aging functions. Through the catalysis of glutathione, it protects human cells from oxidative damage, especially the protection of brain function, and can transmit the biological function of amino acids to promote cell growth; jujube also contains vitamin C and polysaccharides, which have good antioxidant effects and can also provide proteins, minerals and other substances necessary for human endocrine. The polysaccharides and ginseng acid in ginseng can also promote blood circulation, increase the elasticity of dermal cells, thereby increasing skin elasticity, improving the nutrient supply and metabolism level of the skin, and thus improving the health of the skin. DETAILED DESCRIPTION

[0023] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions obtained in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0024] The term "jujube" used in this article refers to the mature fruit of the plant jujube of the genus Ziziphus of the family Rhamnaceae. It is a deciduous small tree, a rare shrub, also known as jujube, thorny jujube, and Guan jujube. It mainly grows in mountainous areas, hills or plains below 1,700 meters. Since ancient times, jujube has been used as food and medicine. Jujube also contains a large amount of vitamins, multiple trace elements and sugars, which have the effects of nourishing the stomach and spleen, benefiting blood, and nourishing the liver. Among them, the content of cyclic phosphate acyl glycosides is rich. According to research, jujube has the function of nourishing and protecting the liver, which can increase liver blood, clean up liver garbage, make the complexion more ruddy, fade spots and wrinkles, and make the skin delicate, smooth and elastic.

[0025] The term "ginseng" refers to the rhizome of the plant of the genus Panax in the Araliaceae family (Latin name: Panax ginseng CAMey.), which is distributed in North America, Central Asia and East Asia. Ginseng is a traditional precious medicinal material in my country, enjoying the reputation of "the king of herbs". It has a history of application in my country for more than 2,000 years. Ginseng contains rich ginsenosides, polysaccharides, ginseng phenols, various amino acids, minerals and trace elements. Modern medicine believes that ginseng has obvious effects on the nervous system, cardiovascular system, endocrine system, reproductive system, etc., and has multiple biological and pharmacological activities such as anti-oxidation, anti-inflammatory, anti-aging, immunity enhancement, and heart protection.

[0026] A composition containing wheat germ extract, wherein the raw material composition ratio of the composition containing wheat germ extract is as follows: 1800-3000 parts of jujube extract, 500-850 parts of wheat germ extract, 200-300 parts of ginseng extract, and 3-10 parts of pyrroloquinoline quinone disodium salt.

[0027] In a preferred case, the composition containing wheat germ extract has the following raw material composition ratios by weight: 2200-2800 parts of jujube extract, 700-800 parts of wheat germ extract, 180-250 parts of ginseng extract, and 4-8 parts of pyrroloquinoline quinone disodium salt.

[0028] In a preferred embodiment, the composition containing wheat germ extract has the following raw material composition ratios by weight: 2500 parts of jujube extract, 750 parts of wheat germ extract, 200 parts of ginseng extract, and 5 parts of pyrroloquinoline quinone disodium salt.

[0029] The jujube extract is obtained by washing, slicing, crushing, extracting, filtering and drying. The preparation method in the specific example is as follows: remove the core of the jujube, wash it with clean water, cut it into 2-3mm jujube particles with a dicer, put the jujube particles into a 0.2% vitamin C solution at 35-40°C for 10-15 minutes to protect the color, and then cook to obtain a slurry, and then use water and / or ethanol as the extraction solvent, the temperature is 40-60°C, the extraction time is 30-90 minutes, extract 1-3 times, filter and concentrate, and then spray dry at 60-80°C to obtain a jujube extract. It should be noted that the raw material of the jujube extract is the mature fruit of the genus Jujube of the Rhamnaceae family rich in cyclic adenosine monophosphate, preferably any one of Xinjiang jujube, golden silk jujube, Ruoqiang gray jujube, sour jujube, dog head jujube, long jujube, winter jujube, and red jujube.

[0030] The wheat germ is separated after washing and peeling, and the wheat germ is softened and extracted to obtain the wheat germ extract. In a specific example, the preparation method is as follows: the wheat is washed, shelled, ground, and washed with water to separate the germ from the wheat, water and / or ethanol are added to the wheat germ as an extraction solvent, the temperature is 60-90°C, the extraction time is 2-3h, and the wheat germ extract is obtained by 1-3 times of extraction, which is filtered and concentrated after cooling, and dried under reduced pressure to obtain the wheat germ extract.

[0031] Wheat germ extract is rich in spermidine. Spermidine can also be extracted from foods such as beans, kelp, mushrooms, nuts, grains or ferns.

[0032] The rhizome of the genus Panax of the Araliaceae family is taken as the raw material, and after cleaning to remove impurities such as dirt and sand, the rhizome is sliced, crushed and purified to obtain ginseng extract. The preparation method in the specific example is as follows: after cleaning to remove impurities such as dirt and sand, the ginseng is cut into 2-3 mm ginseng cubes or crushed into powder, an appropriate amount of water and / or ethanol is used as the extraction solvent, the temperature is 40-60°C, the extraction time is 30-90 minutes, and the ginseng extract is obtained after 1-3 times of extraction, and the ginseng extract is filtered, concentrated and dried to obtain the ginseng extract.

[0033] The present invention also provides the use of the composition containing the wheat germ extract in products for alleviating premature ovarian failure in women, including but not limited to the use in skin care products, medicines, foods, and health care products.

[0034] The present invention also provides a health food, which comprises the above-mentioned composition containing wheat germ extract, and auxiliary materials or additives allowed to be used in health foods. Preferably, the auxiliary materials are any one or any combination of wolfberry, Poria cocos, raspberry, sea buckthorn, peach kernel, γ-aminobutyric acid, vitamin E, vitamin D3, and folic acid. Further, the auxiliary materials are measured by weight, and the component proportions are 80-120 parts of wolfberry, 80-120 parts of Poria cocos, 80-120 parts of raspberry, 120-180 parts of sea buckthorn, and 20-50 parts of peach kernel.

[0035] Health food is a solid or liquid dosage form of granules, oral liquid, tablets or capsules.

[0036] The health food is a granule powder, which is convenient to carry and practical. It has the effects of increasing hormone secretion level and relieving anxiety.

[0037] The plant extract composition is placed in a mixer according to a proportion, stirred for 15-20 minutes to mix evenly, and then edible auxiliary materials and additives are added and mixed into a dough. The mixed dough is placed in a granulator for granulation, and then hot air fluidized bed drying is performed. The particles are dried at 95-115° C. to a moisture content of less than 6%, sieved with a 2-2.5 mm mesh, cooled to room temperature, and packaged.

[0038] Example 1

[0039] Health food preparation

[0040] 1. Take jujube, remove the core, wash with clean water, cut into 3mm jujube particles with a dicer, put the jujube particles into 0.2% vitamin C solution at 40°C for 15 minutes to protect the color, and then cook to obtain slurry, then use water and / or ethanol as extraction solvent, the mass ratio of slurry to extraction solvent is 1:5, the temperature is 50°C, the extraction time is 45 minutes, extract 3 times, filter and concentrate, and then spray dry at 60°C to obtain jujube extract.

[0041] 2. Wash the ginseng to remove dirt, sand and other impurities, cut into 3mm ginseng cubes and crush into powder. Use appropriate amount of water and / or ethanol as extraction solvent, the mass ratio of ginseng to extraction solvent is 1:5, the temperature is 40°C, the extraction time is 45min, and extraction is performed 3 times to obtain ginseng extract. Filter the ginseng extract, concentrate and dry it to obtain ginseng extract.

[0042] 3. Wash and hull the wheat, grind it, and wash it with water to separate the germ from the wheat. Add water and / or ethanol as an extraction solvent to the wheat germ. The mass ratio of the germ to the extraction solvent is 1:4. The temperature is 80°C, the extraction time is 2h, and the extraction is repeated twice to obtain a wheat germ extract. After cooling, the extract is filtered and concentrated, and then dried under reduced pressure to obtain a wheat germ extract.

[0043] 4. A composition containing wheat germ extract, comprising 2500 parts of jujube extract, 750 parts of wheat germ extract, 200 parts of ginseng extract, and 5 parts of pyrroloquinoline quinone disodium salt.

[0044] 5. The composition containing wheat germ extract is placed in a mixer according to the proportion, stirred for 20 minutes to mix evenly, and then edible auxiliary materials and additives are added, and then the dough is prepared, and the prepared dough is placed in a granulator for granulation, and then hot air fluidized bed drying is used, and the granules are dried at 105°C to a moisture content of less than 6%, sieved with a 2.5mm mesh, cooled to room temperature, and packaged with a granule packaging machine according to 7g per small bag. The above production is carried out in a workshop that meets the hygienic requirements of food production.

[0045] Example 2

[0046] Effect test

[0047] 2.1 This test selected 40 women in three stages of 34-36 years old, 44-46 years old, and 54-56 years old to participate in the study. The subjects in each stage were divided into a test group of 20 people and a control group of 20 people. The test group took the granules in Example 1 every day, once in the morning and evening every day, 7g (one bag) each time, and continued to take it for 1 month. The control group took vitamin E as a placebo every day according to the instructions for taking it for 1 month, and then evaluated the results in the test group and the control group. During the test period, the test group and the control group did not use skin care products, and did not interfere with other living habits and life patterns. The improvement effect of menopausal syndrome symptoms was observed using the Menopausal Rating Scale (MRS), and the changes in complexion were recorded by self-evaluation. The improvement of ovarian function was recorded by the changes in anti-Mullerian hormone (AMH) levels and endometrial thickness.

[0048] 2.2 Test subjects were selected according to the following criteria.

[0049] - Healthy women without acute or chronic physical illness, including skin diseases.

[0050] - Those who do not have fever (cold, flu, etc.).

[0051] -Select women who experience menopausal symptoms such as hot flashes, sweating, mood swings, memory loss, fatigue, and insomnia.

[0052] - The thickness of the endometrium in women aged 54-56 is significantly lower than the level of natural atrophy.

[0053] -Sign the voluntary food tasting consent form.

[0054] 2.3 The Menopause Rating Scale (MRS) is a scoring-based questionnaire commonly used to assess menopausal symptoms. It includes not only the patient's physical sensations, but also the patient's psychological sensations and urogenital tract symptoms. There are 11 questions in total, divided into 5 levels (0 none, 1 mild (score 1-4 points), 2 moderate (score 5-8 points), 3 severe (score 9-15 points), 4 very severe (16 and above)). The higher the value, the more severe the menopausal symptoms.

[0055] Table 1 Comparison of MRS scores in the test group before and after taking

[0056] MRS score 34-36 years old (n=20) 44-46 years old (n=20) 54-56 years old (n=20) Week 0 8.62±2.24 15.25±3.16 25.78±2.46 Week 4 4.98±2.03 7.98±3.31 13.32±2.12

[0057] Table 2 Comparison of MRS scores before and after administration in the control group

[0058] MRS score 34-36 years old (n=20) 44-46 years old (n=20) 54-56 years old (n=20) Week 0 8.62±2.24 15.25±3.16 25.78±2.46 Week 4 8.59±2.31 15.32±3.21 25.69±2.42

[0059] As shown in Table 1-2, the result data are expressed as mean ± standard deviation. The scores of the menopausal rating scale of the test group were significantly lower than before treatment, and the menopausal symptoms were effectively improved. The scores of the menopausal rating scale of the control group did not change significantly before and after treatment.

[0060] Table 3 Effect of menopausal symptom scores in the test group and the control group after 1 month (%

[0061]

[0062] Note: Significant: After treatment, all symptoms basically disappeared, and the symptom score decreased by ≥95%;

[0063] Relief - each symptom is significantly alleviated after treatment, with the symptom score decreasing by ≥70% and <95%;

[0064] Effective: All symptoms were alleviated after treatment, and the symptom score decreased by ≥30% and <70%;

[0065] Ineffective: No improvement or aggravation of symptoms after treatment, and the symptom score decreased by <30%.

[0066] As shown in Table 3, after taking the formula composition in Example 1, the total effective rate of menopausal symptom improvement in the 44-46 age group was 85%, and the total effective rate of menopausal symptom improvement in the 54-56 age group was 90%.

[0067] 2.4 The test group reported that after taking the product for one month, 90% of the subjects aged 34-36 had significantly smoother and more delicate skin than before taking the product, and the symptoms of eczema and urticaria on the skin of some women were alleviated; 85% of the subjects aged 44-46 had reduced spider veins on their skin compared to before taking the product; 65% of the subjects aged 54-56 thought that their complexion had improved or become ruddy, and the skin pigmentation of some women had been reduced or significantly lighter. The changes in the control group at each stage were slight or basically unchanged, and some individuals had signs of dull skin due to unstable environment and emotions. This shows that the composition provided by the present invention can improve the skin condition and has the effect of maintaining the skin.

[0068] 2.5 Anti-Mullerian hormone (AMH) is a hormone secreted by the granulosa cells of the small ovarian follicles. It can predict the inventory of ovarian follicles and is an important indicator for evaluating ovarian reserve function. Insufficient ovarian reserve capacity can lead to premature aging of women, prolonged menstrual cycles, aggravated cardiovascular problems, and even symptoms such as menopause, menopause, and infertility. At the same time, studies have shown that the fluctuation of AMH is much smaller than that of other sex hormones. Serum AMH level is also an important indicator for distinguishing premature ovarian failure. The higher the AMH value, the better the ovarian function, and the lower the AMH value, the decreased ovarian function, which affects the ovarian function.

[0069] Table 4 Comparison of anti-Mullerian hormone (AMH) changes in the test group and the control group before and after administration (ng / ml)

[0070]

[0071] From the results in Table 4, it can be seen that compared with before taking the medicine, the AMH values ​​of 85% of the women in the test group at the age of 34-36 were greater than 1, and the AMH values ​​of 100% of the women at the age of 44-46 increased by more than 0.14; the AMH values ​​of the test group were significantly improved after taking the composition of Example 1 of the present invention, and the AMH values ​​of the women at all stages of the control group were basically unchanged, indicating that the composition has a significant improvement effect on premature ovarian failure.

[0072] Around the age of 54-55, the level of anti-Mullerian hormone (AMH) will drop significantly, and the endometrium will naturally shrink to a certain extent. Therefore, women aged 54-56 years old record the changes in the thickness of the endometrium.

[0073] Table 5 Comparison of the thickness of the endometrium before and after taking the test group (mm)

[0074]

[0075] From the results in Table 5, it can be seen that after the test group took the composition of Example 1 of the present invention, the endometrial thickness was significantly improved, while the endometrial thickness of the women in the control group remained basically unchanged.

[0076] The above embodiments are merely illustrative of the principles and effects of the present invention, and are not intended to limit the present invention. Any modifications or changes made by a person skilled in the art without departing from the spirit and technical ideas disclosed in the present invention shall still be covered by the claims of the present invention.

Claims

1. A composition containing wheat germ extract, characterized in that The raw material composition ratio of the composition containing wheat germ extract is as follows: 1800-3000 parts of jujube extract, 500-850 parts of wheat germ extract, 200-300 parts of ginseng extract, and 3-10 parts of pyrroloquinoline quinone disodium salt.

2. The composition containing wheat germ extract according to claim 1, characterized in that The composition containing wheat germ extract has the following raw material composition proportions by weight: 2200-2800 parts of jujube extract, 700-800 parts of wheat germ extract, 180-250 parts of ginseng extract, and 4-8 parts of pyrroloquinoline quinone disodium salt.

3. The composition containing wheat germ extract according to claim 2, characterized in that The composition containing wheat germ extract has the following raw material composition proportions by weight: 2500 parts of jujube extract, 750 parts of wheat germ extract, 200 parts of ginseng extract, and 5 parts of pyrroloquinoline quinone disodium salt.

4. Use of the composition containing wheat germ extract according to any one of claims 1 to 3 in products for alleviating and improving premature ovarian failure and menopausal symptoms in women.

5. A health food, characterized in that: The health food comprises the composition containing the wheat germ extract according to any one of claims 1 to 4 and auxiliary materials or additives permitted for use in health foods.

6. The health food according to claim 5, characterized in that The auxiliary materials or additives are any one or any combination of wolfberry, Poria cocos, raspberry, seabuckthorn, peach kernel, γ-aminobutyric acid, vitamin E, vitamin D3, and folic acid.

7. The health food according to claim 5 or 6, characterized in that: The health food is a granule powder, oral liquid, tablet or capsule.

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