Suspending aid composition for automatic water drinking line dosing and automatic water drinking line dosing method

Abstract

The invention discloses a suspending agent composition for dosing an automatic water drinking line and a dosing method for the automatic water drinking line. The suspending agent composition comprises the following components in percentage by weight: 40-97% of a suspending agent and 3-60% of a salt substance. The viscosity of the feed liquid containing the high-concentration suspending aid prepared from the suspending aid composition is not greatly different from that of the feed liquid diluted by 10-200 times. The feed liquid containing the high-concentration suspending aid can be added into the waterline through automatic dosing equipment and diluted to obtain the aqueous medium with suspension property, so that solid drug particles can be uniformly suspended in the aqueous medium in the waterline.

Description

Technical Field

[0001] The invention belongs to the field of suspending agents, and in particular relates to a suspending agent composition for adding medicine to an automatic drinking water line and a method for adding medicine to the automatic drinking water line. Background Art

[0002] As the scale of aquaculture increases, group dosing has become the mainstream dosing method. What is compatible with large-scale aquaculture is the widespread use of automated water lines and feed lines. Using water lines or feed lines to complete group dosing will definitely become the mainstream dosing method. There are three main dosing methods now, mixed feeding, drinking water and injection. Compared with the stress of injection dosing, mixed feeding and drinking water are much less stressful. Unless a suitable dosing mixing method is used, mixed feeding requires a lot of labor, and the drug mixing is not uniform, which may cause problems such as excessive or insufficient drug intake. Dosing with drinking water can achieve the purpose of relatively uniform dosing with relatively small labor. Relevant equipment and suspending agents are required to achieve uniform dosing.

[0003] The current waterline dosing equipment can be divided into powered dosing equipment and unpowered dosing equipment. Unpowered dosing equipment (also known as waterline automatic dosing equipment, such as automatic dosing pumps, proportional dosing pumps, etc.) is generally generated by the water pressure and flow rate of the waterline itself, and the drug is sucked into the waterline through a specific mechanical design, and the drug is automatically added to the waterline for dilution according to the set adjustment ratio based on the amount of water used at the rear end, and no external energy is required, so it is easy to use. When using automatic dosing equipment for automatic dosing, generally a small volume of corresponding high-concentration liquid is prepared according to the dilution multiple (the high-concentration liquid means that if the liquid is diluted n times to obtain a clinical concentration, then the drug concentration in the high-concentration liquid is n times the clinical concentration), and then the high-concentration liquid is pumped into the waterline according to the dilution ratio and diluted to the required concentration. This method greatly improves the convenience of drug use, reduces labor intensity, and the dosage is accurate. However, only drugs can be prepared into corresponding high-concentration liquid medicines (for example, the drug concentration of the prepared liquid medicines is 10-500 times the clinical use concentration (for example, the concentration in the water line)), and the drugs can be completely dissolved to form a solution to facilitate the use of the automatic dosing device for dosing. The actual situation is that although many drugs can be prepared into solutions of clinical use concentrations (i.e., completely dissolved), they cannot be completely dissolved in the corresponding high-concentration liquid medicines, and solid particles are precipitated, resulting in the drug not being evenly pumped into the water line. In this case, the drug can be prepared into a high-concentration suspension, and then added to the water line by an automatic dosing device to obtain a clinical use concentration in the water line. In other words, for the case where only the high-concentration liquid medicine contains solid particles, and the liquid medicine of the clinical use concentration obtained after dilution is a solution, a suspending agent can be added only to the high-concentration liquid medicine to keep the particles suspended or eliminate particle sedimentation by stirring, so that the drug can be added to the water line by an automatic dosing device in a suspended state.

[0004] However, for drugs that contain solid drug particles in both high-concentration liquid and clinically used concentration liquid (such as coccidia vaccine), it is difficult to add them to the water line through automatic dosing equipment. The reason is that even if the high-concentration liquid is prepared in the form of a suspension, the suspension of the suspension added to the water line and diluted to obtain the clinically used concentration liquid has greatly reduced suspendability, resulting in sedimentation of drug particles, causing uneven drug intake, and precipitation may cause blockage of the water line nozzle. For drugs that contain solid drug particles in both high-concentration liquid and clinically used concentration liquid, two ideal ways to add them to the water line are as follows:

[0005] The first method is to prepare a high-concentration drug suspension and a high-concentration suspension liquid separately. The high-concentration drug suspension (such as coccidia vaccine suspension) has the ability to suspend drug particles (such as coccidia vaccine particles), but the drug suspension is added to the water line, and the suspension of the water medium obtained after dilution decreases a lot, and the drug particles precipitate. After the high-concentration suspension liquid is added to the water line, the water medium in the water line has sufficient suspension, so that the drug particles can be evenly dispersed therein. However, there is no report in the prior art on which suspension agent can prepare a liquid containing a high-concentration suspension agent, and the liquid can be added to the water line through an automatic dosing device, so that the water medium in the water line has sufficient suspension, so that the drug particles are evenly dispersed therein. Because high-concentration suspension liquid generally has poor fluidity or basically loses fluidity (generally, the viscosity of the suspension liquid increases exponentially with respect to its concentration, see, Production and Application of Microbial Polysaccharide-Xanthan Gum. Li Jingwei, Beijing: China Agricultural Science and Technology Press, 1995.87), it cannot be pumped into the water by automatic dosing equipment. However, after reducing the concentration of the high-concentration suspension liquid to increase its fluidity, the same volume of suspension liquid is added to the water line and the water medium in the water line cannot obtain sufficient suspension (causing the solid drug particles to precipitate in the water line).

[0006] The second method is to add solid drug particles to a high-concentration suspension liquid (i.e., the liquid containing the high-concentration suspension also contains high-concentration solid drug particles). The high-concentration suspension liquid meets the requirements for suspending high-concentration drugs, and after the liquid is added to the water line and diluted, the water medium in the water line has sufficient suspension properties, so that the solid drug particles are evenly dispersed therein. It is easy to evenly disperse solid drug particles in a high-concentration suspension liquid. The difficulty is that it is difficult for existing suspending agents to achieve a liquid containing a high concentration of the suspension agent and solid drug particles that has good fluidity (that is, the viscosity of the liquid containing the high-concentration suspension is low), can be pumped into the water line through an automatic dosing device, and the water medium obtained after dilution in the water line has sufficient suspension properties to suspend solid drug particles (that is, the viscosity of the liquid cannot be too low after being diluted by a high multiple).

[0007] In summary, if the automatic dosing of solid drug particles in the drinking water line is realized by the above two methods, it is necessary that the feed liquid containing a high concentration of suspending agent (which may also contain high concentration of solid drug particles) can be added to the water line through the automatic dosing equipment, and after being diluted, the water medium in the water line has sufficient suspension to suspend the solid drug particles, which is a huge challenge. The reason is that the suspension of many suspending agent-containing feed liquids is positively correlated with the viscosity they produce. The greater the viscosity, the greater its suspension capacity, but excessive viscosity will affect the fluidity of the feed liquid. Moreover, the viscosity of the suspending agent-containing feed liquid is usually positively correlated with the concentration of the suspending agent, but the increase in viscosity is not linearly related to the increase in the concentration of the suspending agent, and the viscosity increases in a manner close to an exponential relative to the concentration of the suspending agent. That is, as the concentration of the suspending agent increases, the viscosity of the feed liquid increases rapidly, and the increase in viscosity causes the feed liquid to lose fluidity. It can be seen that whether the suspending agent and the solid drug particles are added to the water line separately or the two are mixed and added to the water line together, the control of the viscosity of the suspending agent-containing feed liquid is the key.

[0008] For example, in order to meet the requirement of suspension of the water medium in the water line, when adding a liquid containing a high concentration of suspending agent and a drug to the water line through an automatic dosing device (the liquid is expected to be diluted 50 times), the concentration of the solid drug particles and the suspending agent in the prepared liquid is 50 times the concentration in the water line, but the actual situation is that the fluidity of the liquid containing such a high concentration of suspending agent is very poor and cannot be smoothly added to the water line through the automatic dosing device. The prior art does not report that the existing suspending agent can prepare a suspending agent whose viscosity of the liquid containing a high concentration (such as 50 times the concentration) of suspending agent is close to or slightly increased from the viscosity of the liquid containing a 1-fold concentration of suspending agent. In other words, the prior art cannot solve the problem of the huge difference in viscosity of the suspending agent liquid at high concentration and low concentration.

[0009] If a general suspending agent is used to prepare a liquid that can suspend high-concentration solid drug particles, but after a high dilution (for example, 50 times), when the drug reaches the required dilution multiple, the suspending agent is also diluted at the same multiple, and the resulting suspension is usually not enough to make the solid drug particles therein evenly suspended therein. Therefore, for solid material particles that are basically insoluble in water and other solvents, it is currently difficult to achieve waterline dosing through automatic dosing equipment.

[0010] Cellulose ether or its derivatives (e.g., delayed dissolution cellulose ether) is a common suspending agent, and the prepared liquid has the same problems as above, i.e., the liquid containing high concentration of cellulose ether has high viscosity and poor fluidity, while the liquid containing lower concentration of suspending agent has good fluidity, but the suspension property of the aqueous medium obtained after being diluted 10 to 200 times is too small to suspend solid drug particles.

[0011] Therefore, there is a need in the art for a suspension composition, wherein the prepared liquid containing a high concentration of suspension has a lower viscosity and can be added to a water line through an automatic dosing device. After being added to the water line and diluted, the water medium in the water line can have sufficient suspending properties for suspending solid drug particles. Summary of the invention

[0012] The present invention aims to provide a suspending agent composition for dosing in a drinking water line, wherein the suspending agent composition comprises the following suspending agent and salt substances in the following weight percentages:

[0013] Suspending agent 40%~97%,

[0014] Salt substances 3% to 60%,

[0015] The suspending agent is selected from cellulose ether or cellulose ether that delays dissolution.

[0016] In another preferred embodiment, when the suspending agent is selected from cellulose ether, it is preferred that the suspending agent and the salt substance are stored separately; when the suspending agent is selected from cellulose ether with delayed dissolution, it is preferred that the suspending agent and the salt substance are mixed and stored together.

[0017] In another preferred embodiment, the cellulose ether is selected from hydroxypropyl methylcellulose, hydroxyethyl methylcellulose, methylcellulose, hydroxyethyl cellulose, or a combination thereof, more preferably, hydroxypropyl methylcellulose.

[0018] In another preferred embodiment, the delayed dissolution cellulose ether is selected from delayed dissolution hydroxypropyl methylcellulose, delayed dissolution hydroxyethyl methylcellulose, delayed dissolution methylcellulose, delayed dissolution hydroxyethyl cellulose, or a combination thereof. In another preferred embodiment, the delayed dissolution cellulose ether is selected from delayed dissolution hydroxypropyl methylcellulose.

[0019] In another preferred embodiment, the salt substance is selected from inorganic salts.

[0020] In another preferred embodiment, the inorganic salt is selected from sodium sulfate, potassium sulfate, magnesium sulfate, ammonium sulfate, sodium chloride, potassium chloride, magnesium chloride, calcium chloride, ammonium chloride, potassium phosphate, sodium phosphate, ammonium phosphate, sodium polyphosphate, potassium polyphosphate, calcium polyphosphate, ammonium polyphosphate, sodium carbonate, potassium carbonate, or a combination thereof.

[0021] In another preferred embodiment, the delayed dissolution cellulose ether is a cellulose ether modified with glyoxal.

[0022] In another preferred embodiment, the suspending agent composition further comprises xanthan gum or a composition comprising xanthan gum.

[0023] In another preferred embodiment, the weight percentage content of the xanthan gum in the suspending agent composition is 0.1-1%.

[0024] Another aspect of the present invention provides a method for adding medicine to an automatic drinking water line, comprising the following steps:

[0025] (1) preparing the above-mentioned suspending agent composition with water into a liquid containing a high concentration of suspending agent, wherein the mass content of the suspending agent is 5-20%, and preferably the salt substance therein is completely dissolved;

[0026] (2) preparing the drug into a uniformly dispersed liquid;

[0027] (3) adding the liquid containing a high concentration of suspending agent prepared in step (1) to the automatic drinking water line by a first automatic dosing device, so that the viscosity of the water medium in the water line is 10 to 500 mPa.s at 6 rpm, and adding the drug solution prepared in step (2) to the automatic drinking water line at a position downstream of the liquid containing a high concentration of suspending agent being added to the automatic drinking water line by a second automatic dosing device, so that the drug is uniformly dispersed in the water medium in the drinking water line,

[0028] The liquid containing the high concentration suspending agent and the liquid containing the drug are diluted in the automatic drinking water line at a ratio of 10 to 200 times, preferably 20 to 100 times.

[0029] In another preferred embodiment, the present invention provides an automatic drinking water line dosing method comprising the following steps:

[0030] (1) preparing the above suspending agent composition with water into a liquid containing a high concentration of suspending agent, wherein the mass content of the suspending agent is 5 to 20%, and preferably the salt substance therein is completely dissolved;

[0031] (2) adding the drug to the liquid containing the high concentration suspending agent in step (1),

[0032] (3) adding the drug-containing liquid prepared in step (2) to the automatic drinking water line through an automatic drug adding device, so that the viscosity of the water medium in the water line is 10 to 500 mPa.s at 6 rpm, and the drug is evenly dispersed therein,

[0033] The drug-containing liquid is diluted in the automatic drinking water line by 10 to 200 times, preferably 20 to 100 times.

[0034] In another preferred embodiment, in the above-mentioned method of adding medicine to the automatic drinking water line, in step (3), the slurry is added to the automatic drinking water line so that the viscosity of the water medium in the water line is 20 to 400 mPa.s at 6 rpm, and more preferably 40 to 300 mPa.s.

[0035] In another preferred embodiment, in the above-mentioned method of adding medicine to the automatic drinking water line, the medicine is selected from the medicine whose liquid material prepared at the clinical concentration contains insoluble particles, and the insoluble particles are less than 100 μm and greater than 1 μm;

[0036] In another preferred embodiment, in the above method of adding medicine to the automatic drinking water line, the medicine is selected from coccidia oocyst vaccine, chemical suspension or feed additive.

[0037] In another more preferred embodiment, in the above-mentioned automatic drinking water line dosing method, the drug is selected from coccidia oocyst vaccine,

[0038] In another preferred embodiment, the chicken coccidia oocyst vaccine, rabbit coccidia oocyst vaccine, pigeon coccidia oocyst vaccine, duck coccidia oocyst vaccine, goose coccidia oocyst vaccine, pig coccidia oocyst vaccine, cattle coccidia oocyst vaccine, sheep coccidia oocyst vaccine, dog coccidia oocyst vaccine, cat coccidia oocyst vaccine, guinea pig coccidia oocyst vaccine.

[0039] In another preferred embodiment, the chemical drug suspension is selected from albendazole suspension and toltrazuril suspension.

[0040] In another preferred embodiment, the feed additive is selected from vitamin additives, trace element additives, and probiotic additives.

[0041] In another preferred example, the probiotic additive is selected from the probiotic additive containing Clostridium butyricum, Bacillus subtilis, Bacillus licheniformis, yeast, Enterococcus faecalis, Enterococcus faecium, Bacillus coagulans, lactic acid bacteria or a combination thereof.

[0042] In another preferred embodiment, in the above-mentioned method for dosing the automatic drinking water line, the preparation process of preparing the suspending agent composition into a liquid containing a high concentration of the suspending agent using water comprises the steps of: first adding the salt substance in the suspending agent composition, and optionally xanthan gum or a xanthan gum composition, into water, and adding the suspending agent after fully dissolving, wherein the suspending agent is selected from cellulose ether, wherein the weight ratio of water to the suspending agent composition is 1:3-18, or,

[0043] The salt substance in the suspending agent composition and the suspending agent, and optionally xanthan gum or a xanthan gum composition, are added into water together, wherein the suspending agent is selected from a cellulose ether with delayed dissolution, and the weight ratio of water to the suspending agent composition is 1:3-18. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] Figure 1 The viscosity at 6 rpm of the feed solution containing different amounts of water obtained in Example 1 is shown. DETAILED DESCRIPTION

[0045] The inventor of the present application found in the process of adding medicine to the water line that when adding medicine using an automatic dosing device (such as a hydrodynamic proportional dilution pump), a small volume of high-concentration liquid medicine can be prepared, added to the water line and diluted to a specified multiple by a proportional dilution pump. This dosing method is simple and the workload of preparing the liquid medicine is small. However, the equipment has strict requirements for the addition, that is, the prepared high-concentration liquid medicine is required to be completely water-soluble, so that the liquid medicine can be evenly drunk after being diluted by the equipment to achieve the effects of quality, prevention and epidemic prevention. However, many drugs are water-soluble at their clinical use concentrations, but cannot be completely dissolved in water at their high concentrations (such as 50-200 times of the clinical use concentration), which causes the prepared high-concentration liquid medicine to contain drug precipitation, affecting the uniformity of dosing. This situation can be prepared by adding a suspending agent to the high-concentration liquid medicine, preparing a stable suspended suspension, adding it to the water line according to a specific dilution multiple, and being diluted into a solution by the water in the water line (that is, at the dilution concentration in the water line, the drug can be dissolved to obtain a uniform liquid medicine), completing the purpose of dosing.

[0046] There is another situation in the actual dosing process: the drug itself is a solid particle, and its solubility in water and other solvents is very small or basically insoluble. Even at the diluted clinical use concentration, it exists in particle form. This requires considering the suspension of the drug solution before and after adding the water line at the same time, and the situation becomes more complicated. At this time, not only the suspension and fluidity of the drug solution and / or suspending liquid at high concentrations should be considered, but also its suspension at low concentrations. In general, the suspension and fluidity of the suspending liquid (i.e., the liquid containing the suspending agent) are contradictory. As mentioned above, the suspension of a general suspension liquid is positively correlated with the viscosity. In other words, the greater the viscosity of the liquid containing the suspending agent, the better the suspension, and the lower the viscosity, the worse the suspension. The viscosity is generally positively correlated with the concentration of the suspending agent in the liquid. However, for most suspending agent liquids, the viscosity and the concentration of the suspending agent are in a nearly exponential relationship, that is, as the suspending agent in the liquid increases, the viscosity of the liquid increases rapidly, and its fluidity decreases rapidly, so that the liquid containing a high concentration of suspending agent does not even have fluidity, and loses the operability of adding it to the water line through automatic dosing equipment. If the suspending agent of the liquid containing the suspending agent is reduced to a viscosity with appropriate fluidity, the same volume of liquid will be too low after being diluted by adding it to the water line, and loses its purpose of suspending particles.

[0047] The inventors of the present application were surprised to find that the viscosity of the prepared suspension would be significantly reduced when salt substances (e.g., common sodium sulfate) were added in the research of feed encapsulation. This performance is exactly what is needed for waterline dosing. Further research found that when the content of salt substances in the water system exceeds 6%, HPMC cannot be hydrated and can maintain a low viscosity. When the feed liquid containing HPMC and salt substances is diluted by a high multiple (e.g., diluted 10 to 200 times), the amount of salt substances is diluted, and the concentration of salt substances can generally be reduced to less than 0.5%. The inhibitory effect of low concentration of salt substances in the water medium on the hydration of HPMC is gradually eliminated, and HPMC is hydrated, resulting in the water medium just reaching the required viscosity value. Further, by adding a small amount of xanthan gum to the feed liquid containing HPMC and salt substances (the hydration of xanthan gum in water is less affected by the concentration of salt substances), the hydration of xanthan gum can produce suspension properties for suspending solid drug particles and unhydrated HPMC particles. The inventors surprisingly found that other similar cellulose ethers and delayed dissolution cellulose ethers (also called "delayed dissolution cellulose") also had similar phenomena. Based on this, the inventors conducted further research and completed the present invention.

[0048] The suspension (liquid) and liquid medicine mentioned in the present invention generally use water as the medium.

[0049] The "salt substances" and "salts" mentioned in the present invention can be used interchangeably.

[0050] The "water line" and "drinking water line" mentioned in the present invention can be used interchangeably.

[0051] In the suspending agent composition for adding medicine to drinking water lines of the present invention, the percentage content of the suspending agent is 40% to 97%, more preferably 45% to 90%, and most preferably 48% to 75%.

[0052] In the suspending agent composition for dosing medicine in drinking water lines of the present invention, the percentage content of salt substances is 3% to 60%, more preferably 10% to 55%, and most preferably 25% to 52%.

[0053] In the suspending agent composition for dosing in drinking water lines of the present invention, when the suspending agent is selected from cellulose ether, it is preferred that the suspending agent and the salt substance are stored separately. The purpose is that when preparing the suspension, the salt substance can be added first, so that the salt substance is completely dissolved to form a solution, thereby inhibiting the cellulose ether added subsequently from hydrating. If the cellulose ether is stored together with the salt substance and added to water at the same time, before the salt substance is completely dissolved in water to form a solution, the cellulose ether has been quickly hydrated to form a "fish eye" that is difficult to eliminate (the hydration rate of the cellulose ether is relatively fast. When the suspending agent powder is added to the water relatively quickly, the cellulose ether powder quickly gathers together, and the outer layer of the cellulose ether powder is quickly hydrated. The hydrated cellulose ether forms a layer of colloid shell due to its viscosity, thereby hindering the contact between water and the internal cellulose ether powder, thereby hindering the hydration of the internal cellulose ether powder, forming a structure of a flocculent with an external hydrated cellulose ether enveloping an internal unhydrated cellulose ether powder. This state is generally referred to as a "fish eye"), which is difficult to eliminate. Unless otherwise specified, the water used is water at room temperature. From the perspective of actual application, room temperature water is the most convenient to use.

[0054] In the suspending agent composition for dosing in drinking water lines of the present invention, when the suspending agent is selected from the delayed dissolution cellulose ether, it is preferred that the suspending agent is mixed with the salt substance and stored together. The purpose is that when preparing the suspension, the two can be added to water together, which is convenient for preparing the suspension. The initial hydration speed of the delayed dissolution cellulose ether in water is slower than the speed at which the salt substance is completely dissolved in water to form a solution. Therefore, after the two are added to water at the same time, a certain concentration of salt formed in the water medium can inhibit the hydration of the cellulose ether that has not yet been hydrated.

[0055] The cellulose ethers of the present invention include but are not limited to hydroxypropyl methylcellulose, hydroxyethyl methylcellulose, methylcellulose, and hydroxyethyl cellulose.

[0056] The delayed dissolution cellulose ethers of the present invention include, but are not limited to, delayed dissolution hydroxypropyl methylcellulose, delayed dissolution hydroxyethyl methylcellulose, delayed dissolution methylcellulose, delayed dissolution hydroxyethyl cellulose, or a combination thereof.

[0057] Cellulose ether water-soluble polymer materials have good water solubility, viscosity deformability and biodegradability, and are widely used in industries such as construction, medicine, food, daily chemicals, and energy. In order to solve the hydration (dissolution) problem of cellulose ether in cold water, industrial application cellulose ether usually adopts a surface treatment method (for example, surface treatment with glyoxal) to protect the hydroxyl groups on its surface through derivatization, such as forming an acetal structure with glyoxal, and such products are called delayed dissolution cellulose ether or delayed dissolution type cellulose ether. Due to the surface treatment, the initial hydration rate (i.e., the dissolution rate) of cellulose ether added to water is significantly slowed down. After being added to water, it quickly disperses in water and then gradually hydrates to form a homogeneous suspension system. Delayed dissolution cellulose ether can be prepared according to the method disclosed in the prior art CN1421462A, or purchased from the market. The hydration process of cellulose ether is that the hydroxyl groups on its surface associate with water molecules. The hydroxyl groups on the surface of the delayed dissolution cellulose ether form an acetal structure. After being added to water, the acetal structure on the surface must be opened first to release the hydroxyl groups, and then the hydroxyl groups associate with water molecules, so the initial hydration rate is slow.

[0058] The trade name of delayed dissolution cellulose ether usually contains S, which means instant dissolution. The reason for instant dissolution is that the dissolution and hydration are delayed, so that the powder can be fully dispersed in water when it contacts water, without forming large "fish eyes", and then the final instant dissolution effect is achieved. Therefore, delayed dissolution cellulose ether can also be called "delayed hydration type cellulose ether" or "instant soluble cellulose ether". When ordinary cellulose ether without surface treatment is added to water, the contact part with water is quickly hydrated, and the quickly hydrated part forms an outer sticky layer, which wraps the unhydrated cellulose ether powder inside, forming "fish eyes", which hinders the contact between water and the internal cellulose ether powder. In the end, it is because of the fast microscopic hydration speed that the final macroscopic hydration speed is slow.

[0059] The salt substances of the present invention include but are not limited to inorganic salts. More preferably, the inorganic salt is selected from sodium sulfate, potassium sulfate, magnesium sulfate, ammonium sulfate, sodium chloride, potassium chloride, magnesium chloride, calcium chloride, ammonium chloride, potassium phosphate, sodium phosphate, ammonium phosphate, sodium polyphosphate, potassium polyphosphate, calcium polyphosphate, ammonium polyphosphate, sodium carbonate, and potassium carbonate.

[0060] The suspending agent composition of the present invention is prepared into a slurry containing high-concentration cellulose ether by water. Due to the inhibitory effect of salt therein, the cellulose ether cannot be hydrated, so the viscosity is small and the fluidity is good. The slurry is pumped into the dilution liquid formed after the water line by automatic dosing equipment in proportion. Because the equipment can be high-multiple dilution dosing, it skips the intermediate concentration from the high concentration and directly enters the high-multiple dilution low concentration. The low-concentration salt is not enough to inhibit the hydration of the cellulose ether. After the cellulose ether is hydrated, the viscosity of the water medium in the water line is increased, which is sufficient to suspend the common solid drug particles in the liquid.

[0061] The invention is designed for the purpose of adding medicine to the drinking water line. The added medicine refers to the medicine liquid containing water-insoluble or incompletely soluble medicine particles in its high concentration, and the medicine liquid at the clinical use concentration in the drinking water line also contains water-insoluble or incompletely soluble medicine particles. Such as chemical medicine suspensions with poor solubility or basically insoluble in water and other solvents, feed additives (vitamin additives, trace element additives, probiotic additives), biological vaccines (for example, coccidia oocyst vaccines), etc.

[0062] The composition used in the present invention may contain, in addition to the above-mentioned short rheology rheological agent HPMC, salt substances and / or xanthan gum, a fluidity regulator, a pigment indicator, a functional component, a dispersing auxiliary material, etc. These components preferably have a large solubility so that they can be completely dissolved in the feed liquid containing a high concentration of the suspending agent and the water medium of the water line (i.e., the diluent of the feed liquid containing a high concentration of the suspending agent). Because these components are insoluble, or insoluble at high concentrations, they will bring more variables to the suspension, which is not conducive to formulation design and operation.

[0063] The dispersing auxiliary material can be selected from non-ionic auxiliary materials such as glucose, sucrose, maltodextrin, etc., and its weight percentage in the suspension composition of the present invention is preferably 0%-98%. The function of the dispersing auxiliary material is to disperse the rheological agent, fluidity regulator, pigment indicator, functional component, etc. to obtain a uniformly dispersed composition. 0% means no addition.

[0064] The flow regulator can be selected from aerosil, hydrated silicon dioxide, silicon spheres, hollow silicon dioxide, drying powder, etc. The weight percentage of the flow regulator in the suspending agent composition of the present invention is preferably 0%-20%. The function of the flow regulator is to make the composition have good fluidity during preparation and use, and also make the composition more uniform. 0% means no addition.

[0065] The color indicator can be selected from edible pigments, such as brilliant blue, indigo, lemon yellow, carmine, amaranth, etc. The weight percentage of the color indicator in the suspending agent composition of the present invention is preferably 0%-10%. 0% means that no color indicator is added.

[0066] The functional component can be selected from vitamin substances and / or amino acid substances and / or other pharmaceutical ingredients. The weight percentage of the functional component in the suspending agent composition of the present invention is preferably 0%-40%. The functional component can be stably present in the suspending agent composition of the present invention. In some preferred embodiments of the present invention, the functional component is selected from methionine and / or lysine. 0% means no addition.

[0067] The coccidia oocyst vaccine mentioned in the present invention includes but is not limited to chicken coccidia oocyst vaccine, rabbit coccidia oocyst vaccine, pigeon coccidia oocyst vaccine, duck coccidia oocyst vaccine, goose coccidia oocyst vaccine, pig coccidia oocyst vaccine, cattle coccidia oocyst vaccine, sheep coccidia oocyst vaccine, dog coccidia oocyst vaccine, cat coccidia oocyst vaccine, guinea pig coccidia oocyst vaccine, etc. Because of the host specificity of coccidiosis, it is preferred that these vaccines are used in accordance with their corresponding host animals.

[0068] In some specific embodiments of the present invention, the automatic drinking water line dosing method comprises the following steps:

[0069] (1) preparing the above suspending agent composition with water into a liquid containing a high concentration of suspending agent, wherein the mass content of the suspending agent is 5 to 20%, and preferably the salt substance therein is completely dissolved;

[0070] (2) preparing the drug into a uniformly dispersed liquid;

[0071] (3) adding the liquid containing a high concentration of suspending agent prepared in step (1) to the automatic drinking water line by a first automatic dosing device, so that the viscosity of the water medium in the water line is 10 to 500 mPa.s at 6 rpm, and adding the drug solution prepared in step (2) to the automatic drinking water line at a position downstream of the liquid containing a high concentration of suspending agent being added to the automatic drinking water line by a second automatic dosing device, so that the drug is uniformly dispersed in the water medium in the drinking water line,

[0072] The liquid containing the high concentration suspending agent and the liquid containing the drug are diluted in the automatic drinking water line at a ratio of 10 to 200 times, preferably 20 to 100 times.

[0073] In some specific embodiments of the present invention, the automatic drinking water line dosing method comprises the following steps:

[0074] (1) preparing the above suspending agent composition with water into a liquid containing a high concentration of suspending agent, wherein the mass content of the suspending agent is 5 to 20%, and preferably the salt substance therein is completely dissolved;

[0075] (2) adding the drug to the liquid containing the high concentration suspending agent in step (1);

[0076] (3) adding the drug-containing liquid prepared in step (2) to the automatic drinking water line through an automatic drug adding device, so that the viscosity of the water medium in the water line is 10 to 500 mPa.s at 6 rpm, and the drug is evenly dispersed therein,

[0077] The drug-containing liquid is diluted in the automatic drinking water line by 10 to 200 times, preferably 20 to 100 times.

[0078] The method for adding medicine to the automatic drinking water line of the present invention is to use the suspending agent composition of the present invention to prepare a low-viscosity feed liquid containing high-concentration cellulose ether (with good fluidity and can be added to the water line through an automatic dosing device), and the water medium formed after the feed liquid is highly diluted (for example, diluted 10 to 200 times, preferably 20 to 100 times) has sufficient suspension (having a certain viscosity, for example, 40 to 100 mPa.s) to suspend common solid drug particles (for example, coccidia oocyst vaccine).

[0079] The present invention will be further described below in conjunction with specific examples. Specific examples are implemented under the premise of technical solutions of the present invention, and detailed implementation methods and operating procedures are provided. It should be understood that these examples are only used to illustrate the present invention and are not intended to limit the scope of the present invention. The experimental methods for which specific conditions are not specified in the following examples are usually carried out under normal conditions. Unless otherwise indicated, ratios and percentages are by weight.

[0080] The viscosity test was conducted at various rotation speeds using a rotational viscometer [NDJ-1 Rotational Viscometer, Shanghai Yueping Scientific Instrument Co., Ltd.].

[0081] Example 1

[0082] The composition of the waterline dosing suspending agent composition is shown in Table 1-1. The two components are stored separately.

[0083] Table 1-1. Suspending agent composition

[0084] Components Hydroxypropyl methylcellulose 100,000 Sodium sulfate Dosage 50g 50g

[0085] Hydroxypropyl methylcellulose 100,000 is ordinary hydroxypropyl methylcellulose without surface treatment.

[0086] Prepare a feed solution containing hydroxypropyl methylcellulose and test the viscosity of the feed solution with different water contents: weigh 100g of tap water, add 24g of sodium sulfate, stir to dissolve, add 24g of hydroxypropyl methylcellulose (HPMC 100,000), stir well to prepare a feed solution, test its viscosity, then continue to add water thereto, stir well, and test its viscosity again to obtain the viscosity data of the feed solution with different water contents, as shown in Table 1-2 below, and plot the viscosity at 6rpm, as shown in Table 1-2 below. Figure 1 shown.

[0087] Table 1-2

[0088]

[0089]

[0090]

[0091] From Table 1-1 and Figure 1 It can be seen that for the feed liquid prepared with the above suspending agent composition, when the amount of water is 100-400g, although its viscosity shows a trend of first decreasing and then slightly increasing, overall, the viscosity is maintained at a relatively low state, and the liquid material has good fluidity. At this time, the amount of sodium sulfate (i.e., sodium sulfate) is higher than 6% (6%-24%) relative to the amount of water, and the amount of HPMC is higher than 6% (6%-24%) relative to the amount of water. For the above feed liquid, when the amount of water is 200-400g, its viscosity changes very little, that is, when sodium sulfate is higher than 6% (6%-12%) relative to water, sodium sulfate can inhibit the hydration of HPMC. In this water content range, the feed liquid contains a high concentration of HPMC (6%-12%), while maintaining low viscosity and having good fluidity.

[0092] When the amount of water is further increased, the viscosity of the feed liquid rises sharply. When the amount of water increases to 500g, the viscosity of the feed liquid has exceeded the maximum range of the laboratory instrument of 10Pa.s. At this time, the fluidity of the feed liquid deteriorates and it is almost impossible to flow. When the amount of water is further increased to 1600g, the viscosity of the feed liquid drops to about 8Pa.s. When the amount of water is further increased, the viscosity continues to drop. When the amount of water reaches 8800g, the viscosity of the feed liquid drops to 45mPa.s. At this time, the viscosity of the feed liquid is close to the viscosity of the feed liquid containing 200g of water. It is equivalent to the viscosity of the feed liquid containing 200g of water before and after being diluted about 44 times. Comparing the viscosity of the feed liquid containing 100g of water (about 300mPa.s) with the viscosity of the feed liquid containing 8800g of water (45mPa.s), it can be seen that the viscosity of the feed liquid containing 100g of water after dilution 88 times is not much different from the viscosity before dilution. According to the viscosity of water that can suspend common chicken coccidia oocyst vaccines, when the viscosity of the water medium is 40mPa.s, it can fully meet the requirement of suspending chicken coccidia oocysts for 6 hours. Therefore, for the suspending agent composition of this embodiment 1, the low viscosity region of the prepared feed liquid containing about 100-200g of water can be used as the operating point of the feed liquid containing a high content of suspending agent; and the viscosity point of the feed liquid containing about 8800g or more of water is the operating point of the water medium in the water line after high dilution.

[0093] Example 2

[0094] The composition of the waterline dosing suspending agent composition is shown in Table 2-1. The two components are stored separately.

[0095] Table 2-1

[0096] Components Hydroxypropyl methylcellulose 100,000 Sodium sulfate content 68g 32g

[0097] Directions:

[0098] 32g of sodium sulfate in the above composition was added to 500mL of water to fully dissolve, and then 100,068g of the above hydroxypropyl methylcellulose was added to obtain liquid 2a, and its viscosity was measured to be 2A (see Table 2-2). The viscosity of the liquid (suspension concentrate) was low, and hydroxypropyl methylcellulose (HPMC) existed in the liquid in an unhydrated form.

[0099] The feed liquid 2a is added to the water line using a dosing device, and the dilution ratio is set to 50 times. The feed liquid 2a is added to the water line under stirring, and then a sample is taken at a position 20m downstream of the position where the feed liquid is added to the water line. The viscosity of the water medium (referred to as feed liquid 2b) in the test water line is 2B (see Table 2-2). The measurement at a position 20m downstream of the position where the feed liquid is added to the water line is because there is a distance from the position where the feed liquid is added to the water line to the position where the animal begins to use the diluent. The distance is generally greater than 20m, and some are even 50m. The water flow speed in this distance is faster, and the flow is generally turbulent, which can promote hydration. In addition, it takes a certain amount of time for the feed liquid to be fully hydrated after being added to the water line, and flowing to 20 meters can generally meet the requirements of hydration time.

[0100] Take another 10 g of the above-mentioned liquid 2a, add it into 490 g of water to prepare liquid 2c, stir it thoroughly for hydration, and test its viscosity, which is 2C (see Table 2-2).

[0101] Take another 1.13g HPMC100,000 and add it to 499g water to prepare the liquid for 2d. Stir it thoroughly and test its viscosity to find it is 2D (see Table 2-2).

[0102] Another 68g of hydroxypropyl methylcellulose was added to 532mL of water to prepare liquid 2e. After sufficient stirring, the viscosity was tested to be 2E. It was found that the viscosity at 6rpm exceeded the measurement range of the equipment by 10Pa.s. It was inferred that it was at least greater than 10Pa.s. In fact, the liquid no longer had fluidity and operability to be diluted and hydrated by adding water.

[0103] Table 2-2

[0104] Viscosity / mPa.s 6rpm 12rpm 30rpm 60rpm 2A 105.0 78.5 65.4 56.0 2B 38.8 37.0 35.2 32.6 2C 39.4 38.5 35.2 33.1 2D 38.9 37.9 35.7 33.4

[0105] As can be seen from Table 1-2, the viscosity of feed 2a at 6 rpm is 105 mPa.s, and its fluidity is good; the viscosity 2B at 6 rpm obtained by adding feed 2a to the water line and diluting it 50 times is basically the same as the viscosity 2C of the feed obtained by directly diluting the feed 50 times with water and the viscosity 2D of the feed obtained by adding 1.13g HPMC to 499g water, which is about 1 / 3 times the viscosity 1A. For feed 2a, the multiple of its viscosity reduction is much smaller than the multiple of dilution.

[0106] Generally, after the feed liquid containing the suspending agent is diluted 50 times, its viscosity is much less than 1 / 50 of the original viscosity; and the viscosity 2B, 2C and 2D of the feed liquids 2a, 2b and 2c obtained in this embodiment can be considered to be not much different within the error range, indicating that the rapid hydration of the suspending agent can be obtained by the above method. In addition, the viscosity 2B of the feed liquid 2b is close to the viscosity 2D data of the feed liquid 2d prepared with the same amount of HPMC without adding salt. This shows that 100,000 hydroxypropyl methylcellulose and sodium sulfate can be quickly hydrated in the water line by first being prepared into the feed liquid 2a and then added to the water line, and its viscosity is basically not affected by salt after dilution in the water line.

[0107] In Table 1-2, there is little difference between viscosity 2B and viscosity 2C, indicating that liquid 2a has basically completed hydration 20m downstream of the location where the water line is added.

[0108] In this embodiment, 100,000 hydroxypropyl methylcellulose and sodium sulfate are stored separately because the hydration speed of hydroxypropyl methylcellulose is fast when added to water. If the two are mixed together, sodium sulfate cannot dissolve quickly when just added, and the concentration of sodium sulfate in the aqueous medium is low, which is not enough to inhibit the hydration of hydroxypropyl methylcellulose. Hydroxypropyl methylcellulose forms "fish eyes" because of the too fast hydration speed. If they are stored separately, when preparing the feed liquid (suspension), sodium sulfate can be added to water first, and sodium sulfate can be fully dissolved to obtain a sodium sulfate aqueous solution of sufficient concentration, and then hydroxypropyl methylcellulose can be added. At this time, the concentration of sodium sulfate in the water can inhibit the hydration of hydroxypropyl methylcellulose, and a feed liquid containing high concentration of hydroxypropyl methylcellulose with low viscosity can be obtained.

[0109] Similar water-soluble cellulose and similar salts are stored separately and added into water in sequence when preparing the feed liquid, so that a low-viscosity feed liquid containing high-concentration cellulose can also be obtained.

[0110] Example 3

[0111] The composition of the waterline dosing suspending agent composition is shown in Table 3-1. The two components are fully mixed and evenly stored together. Among them, delayed dissolution (hydrated) hydroxypropyl methylcellulose 100,000 S is a commercially available product.

[0112] Table 3-1

[0113] Components Delayed dissolution (hydration) hydroxypropyl methylcellulose 100,000 S Sodium sulfate content 68g 32g

[0114] Delayed dissolution (hydration) hydroxypropyl methylcellulose 100,000 S is a surface-treated hydroxypropyl methylcellulose product, and its hydration rate in water is slow. Therefore, delayed dissolution hydroxypropyl methylcellulose 100,000 S can be mixed with sodium sulfate and added to water. After both are added to water at the same time, before the delayed dissolution hydroxypropyl methylcellulose is hydrated, the sodium sulfate has been fully dissolved to form a high-concentration saline solution, which can inhibit the hydration of hydroxypropyl methylcellulose.

[0115] 100 g of the above mixture was added to 500 g of water under stirring to obtain a liquid, in which HPMC existed in an unhydrated form and was in a dispersed state. The viscosity was tested to be 3A (see Table 3-2).

[0116] The liquid was added to the water line using an automatic dosing device, the dilution ratio was set to 50 times, and then the liquid was added to the water line under stirring. A sample was taken 20m downstream of the position where the liquid was added to the water line. The viscosity of the sampled water medium was tested to be 3B (see Table 3-2).

[0117] Table 3-2

[0118] Viscosity 6rpm 12rpm 30rpm 60rpm 3A 100.0 74.5 60.0 54.2 3B 35.0 31.5 30.6 28.5

[0119] It can be seen that the delayed dissolution (hydrated) hydroxypropyl methylcellulose can be mixed with salt for storage, and both can be added to water at the same time when preparing the feed solution. Compared with the suspending agent composition of Example 2 in which the two components are stored separately, the suspending agent composition of this embodiment is more convenient to transport and use, and the viscosity of the aqueous medium obtained after dilution is equivalent to that of Example 2. The viscosity difference may be related to the difference between different batches of products and the slight effect of surface treatment on viscosity.

[0120] Example 4

[0121] The composition of the waterline dosing suspending agent composition is shown in Table 4-1, wherein the three components are fully mixed and stored together.

[0122] Table 4-1

[0123] Components Delayed dissolution (hydrated) Hydroxypropyl methylcellulose 100,000 S Potassium sulfate Sodium Polyphosphate Dosage 68g 32g 5

[0124] 105g of the mixture is added to 495g of water to obtain a feed liquid, in which the delayed dissolution (hydration) of the hydroxypropyl methylcellulose is substantially not hydrated, so as to obtain a particle form and dispersed in water. The viscosity of the feed liquid was tested to be 4A (see Table 4-2). Similar to Example 3, the sodium sulfate in the liquid material inhibits the hydration of the delayed dissolution (hydration) of the hydroxypropyl methylcellulose, and sodium polyphosphate also has a certain inhibitory effect on the hydration of the hydroxypropyl methylcellulose. When the feed liquid is added to the water line and diluted, the inhibitory hydration of potassium sulfate disappears, and the weak alkalinity of sodium polyphosphate can promote the opening of the acetal structure of the hydroxypropyl methylcellulose that delays dissolution (hydration), and plays a role in rapid hydration.

[0125] The feed liquid was added into the water line using an automatic dosing device, the dilution ratio was set to 50 times, and then a sample was taken 20m downstream of the position where the feed liquid was added into the water line. The viscosity of the water medium was tested to be 4B (see Table 4-2).

[0126] Table 4-2

[0127] Viscosity 6rpm 12rpm 30rpm 60rpm 4A 110.0 79.5 66.6 60.5 4B 34.2 33.0 31.5 30.7

[0128] It can be seen from Table 4-2 that the viscosity of the slurry obtained in this example and its viscosity after being diluted in the water line are similar to those in Example 3. The slight difference in viscosity may be related to the weighing error and the effect of sodium polyphosphate.

[0129] Example 5

[0130] The composition of the waterline dosing suspension composition is shown in Table 5-1. Xanthan gum is first prepared into granules with polyethylene glycol (refer to the method of patent ZL202211611939.2), sieved to obtain granules of about 40 mesh (about 0.425 mm), and then fully mixed with delayed dissolution (hydrated) hydroxypropyl methylcellulose 200,000 S and sodium sulfate and stored together.

[0131] Table 5-1. Composition of waterline suspending agent composition

[0132]

[0133] 100 g of the above composition was added to 500 g of water under stirring, and in the obtained liquid material, hydroxypropyl methylcellulose was basically not hydrated, but xanthan gum was almost unaffected by salt and was basically completely hydrated. The viscosity of the liquid material was tested to be 5A (see Table 5-2).

[0134] The feed liquid was added into the water line using an automatic dosing device, the dilution ratio was set to 50 times, and then a sample was taken 20m downstream of the position where the feed liquid was added into the water line. The viscosity of the water medium was tested to be 5B (see Table 5-2).

[0135] In addition, 2 hours after the feed liquid was added to the water line using the automatic dosing equipment, a sample was taken again at a position 20m downstream of the position where the feed liquid was added to the water line, and the viscosity of the water medium was tested to be 5C (see Table 5-2).

[0136] Table 5-2

[0137] Viscosity 6rpm 12rpm 30rpm 60rpm 5A 1475.0 1002.5 599.0 417.5 5B 52.6 46.5 43.2 39.5 5C 54.0 48.0 44.0 41.1

[0138] As can be seen from the data in Table 5-2, when xanthan gum is added to the waterline suspending agent composition, when preparing the feed liquid of high concentration hydroxypropyl methylcellulose, the hydration of xanthan gum is basically not affected by salt, and the prepared xanthan gum particles can be hydrated, so that the liquid material produces suspension, and the unhydrated HPMC particles can be suspended. The feed liquid can be added to the waterline without stirring, and the effect of uniform addition can be achieved without the sedimentation of HPMC. Although the viscosity of the feed liquid is relatively large, the thixotropy is also relatively large, so the fluidity is still good. The viscosity difference of the aqueous medium in the waterline sampled at different times is very small, indicating that the obtained suspension can maintain stable suspension for a long time. The viscosity of the aqueous medium in the obtained water line is greater than that in Example 4, which is mainly related to the viscosity of the delayed dissolution (hydration) hydroxypropyl methylcellulose 200,000 S brand product used in this example, which is greater than the viscosity of the delayed dissolution (hydration) hydroxypropyl methylcellulose 100,000 S brand product. The thixotropy of the viscosity of the aqueous medium in the obtained water line is greater than that in Example 3, which should be related to the high viscosity of the delayed dissolution hydroxypropyl methylcellulose 200,000 S itself, and the slightly greater thixotropy. In addition, it is also related to the thixotropic property of xanthan gum itself.

[0139] Example 6

[0140] The composition of the waterline dosing suspending agent composition is shown in Table 6-1. The three components are fully mixed and stored together.

[0141] Table 6-1

[0142]

[0143] 100 g of the waterline suspending agent composition was added to 500 mL of water to prepare a liquid, and then 10 g of rabbit coccidiosis vaccine was added to the liquid. The viscosity was tested to be 6A (see Table 6-2).

[0144] The feed liquid was added into the water line using an automatic dosing device, the dilution ratio was set to 50 times, and then a sample was taken 20m downstream of the position where the feed liquid was added into the water line. The viscosity of the water medium was tested to be 6B (see Table 6-2).

[0145] In addition, 2 hours after the feed liquid was added to the water line using the automatic dosing equipment, a sample was taken again at a position 20m downstream of the position where the feed liquid was added to the water line, and the viscosity of the water medium was tested to be 6C (see Table 6-2).

[0146] Table 6-2

[0147] Viscosity 6rpm 12rpm 30rpm 60rpm 6A 350.0 242.0 159.2 121.0 6B 52.7 46.5 42.4 39.2 6C 52.9 46.0 42.6 40.0

[0148] It can be seen from Table 6-2 that the viscosity of the slurry obtained in this embodiment and the aqueous medium obtained by dilution in the water line is similar to that in Example 5. However, since the amount of xanthan gum used is less than that in Example 5, the viscosity 6A is smaller than the viscosity 5A, and the viscosities 6B and 6C of the aqueous medium in the water line obtained after dilution are slightly different from the viscosities 5B and 5C of Example 5, respectively, which may be related to the measurement error.

[0149] Referring to the method in method ZL2022116119392, the suspension performance of suspensions with viscosities of 6B and 6C (i.e., the water medium in the obtained waterline) on chicken coccidia oocysts (manufacturer: Foshan Zhengdian Biotechnology Co., Ltd., model: Chicken Coccidiosis Quadrivalent Live Vaccine) was tested respectively, and the theoretical number of oocysts was recorded as 100. The results are shown in Table 6-3.

[0150] Table 6-3

[0151] Sampling point 0h 4h 6h The number of oocysts in the upper layer of the suspension with a viscosity of 6B 98±4 96±10 90±16 The number of oocysts in the lower layer of the suspension with a viscosity of 6B 94±18 104±10 102±12 The number of oocysts in the upper layer of the suspension with a viscosity of 6C 92±10 100±8 96±14 The number of oocysts in the lower layer of the suspension with a viscosity of 6C 88±12 86±12 94±10

[0152] From the data in Table 6-3, it can be seen that the suspensions sampled at different times not only have similar viscosity data, but also similar suspension properties for chicken coccidia oocysts, indicating that the water medium obtained by adding the above-mentioned liquid to the water line can at least meet the requirement of oocyst suspension for 6 hours, and has good water line usability.

[0153] Example 7

[0154] The composition of the waterline dosing suspending agent composition is shown in Table 7-1, wherein the two components are fully mixed and stored together.

[0155] Table 7-1

[0156] Components Delayed dissolution (hydrated) Hydroxypropyl methylcellulose 200,000 S Potassium chloride Dosage 40g 30g

[0157] 70 g of the above mixture was added to 250 g of water to obtain a liquid, in which hydroxypropyl methylcellulose was dispersed. The viscosity was tested to be 7A.

[0158] The feed liquid was added into the water line using an automatic dosing device, the dilution ratio was set to 60 times, and then a sample was taken 20m downstream of the position where the feed liquid was added into the water line. The viscosity of the water medium was tested to be 7B (see Table 7-2).

[0159] Table 7-2

[0160] Viscosity 6rpm 12rpm 30rpm 60rpm 7A 380.0 278.5 189.0 155.0 7B 53.0 47.5 44.6 42.0

[0161] It can be seen from Table 7-2 that high concentration potassium chloride aqueous solution significantly inhibits the hydration of hydroxypropyl methylcellulose.

[0162] Example 8

[0163] The composition of the waterline dosing suspending agent composition is shown in Table 8-1, wherein the two components are fully mixed and stored together.

[0164] Table 8-1

[0165] Components Delayed dissolution (hydrated) Hydroxypropyl methylcellulose 100,000 S Sodium chloride Dosage 68g 32g

[0166] 100 g of the above mixture was added to 500 g of water to obtain a liquid, in which hydroxypropyl methylcellulose was dispersed. The viscosity was tested to be 8A.

[0167] The liquid was added into the water line using an automatic dosing device, the dilution ratio was set to 50 times, and then a sample was taken 20m downstream of the position where the liquid was added into the water line. The viscosity of the water medium was tested to be 8B (see Table 8-2).

[0168] Table 8-2

[0169] Viscosity 6rpm 12rpm 30rpm 60rpm 8A 108.0 79.5 66.2 54.1 8A 34.0 32.0 31.0 29.2

[0170] It can be seen from Table 8-2 that the composition of this example can obtain similar results to those of Example 3, and the high-concentration potassium chloride aqueous solution significantly inhibits the hydration of hydroxypropyl methylcellulose.

[0171] It can be seen from the above examples that the change in viscosity of the waterline dosing suspending agent composition of the present invention before and after dilution is significantly smaller than the change in the concentration of the suspending agent therein, which makes it possible to obtain the desired viscosity by high dilution.

[0172] The above description is only a preferred embodiment of the present invention, and is not intended to limit the scope of the present invention. The above embodiment of the present invention can also be modified in various ways. That is, all simple, equivalent changes and modifications made according to the claims and the contents of the specification of the present invention fall within the scope of protection of the claims of the present invention. The contents not described in detail in the present invention are all conventional technical contents.

Claims

1. A suspending agent composition for dosing in an automatic drinking water line, characterized in that: The suspending agent composition comprises the following suspending agents and salt substances in the following weight percentages: Suspending agent 40%~97%, Salt substances 3% to 60%, The suspending agent is selected from cellulose ether or cellulose ether that delays dissolution.

2. The suspending agent composition according to claim 1, characterized in that When the suspending agent is selected from cellulose ether, it is preferred that the suspending agent and the salt substance are stored separately; when the suspending agent is selected from cellulose ether with delayed dissolution, it is preferred that the suspending agent and the salt substance are mixed and stored together.

3. The suspending agent composition according to claim 1 or 2, characterized in that The cellulose ether is selected from hydroxypropyl methylcellulose, hydroxyethyl methylcellulose, methylcellulose, hydroxyethyl cellulose, or a combination thereof, more preferably, hydroxypropyl methylcellulose; and / or The delayed dissolution cellulose ether is selected from delayed dissolution hydroxypropyl methylcellulose, delayed dissolution hydroxyethyl methylcellulose, delayed dissolution methylcellulose, delayed dissolution hydroxyethyl cellulose, or a combination thereof, more preferably, delayed dissolution hydroxypropyl methylcellulose; and / or The salt substance is selected from inorganic salts, more preferably, the inorganic salt is selected from sodium sulfate, potassium sulfate, magnesium sulfate, ammonium sulfate, sodium chloride, potassium chloride, magnesium chloride, calcium chloride, ammonium chloride, potassium phosphate, sodium phosphate, ammonium phosphate, sodium polyphosphate, potassium polyphosphate, calcium polyphosphate, ammonium polyphosphate, sodium carbonate, potassium carbonate, or a combination thereof.

4. The suspending agent composition according to claim 1 or 2, characterized in that: The delayed dissolution cellulose ether is a cellulose ether modified with glyoxal.

5. The suspending agent composition according to claim 1 or 2, characterized in that: The suspending agent composition further comprises xanthan gum or a composition comprising xanthan gum, Preferably, the weight percentage content of the xanthan gum in the suspending agent composition is 0.1-1%.

6. A method for adding medicine to an automatic drinking water line, characterized in that: The method comprises the following steps: (1) The suspending agent composition according to any one of claims 1 to 5 is prepared into a liquid containing a high concentration of the suspending agent using water, wherein the mass content of the suspending agent is 5 to 20%, and preferably the salt substance therein is completely dissolved; (2) preparing the drug into a uniformly dispersed liquid; (3) adding the liquid containing a high concentration of suspending agent prepared in step (1) to the automatic drinking water line by a first automatic dosing device, so that the viscosity of the water medium in the water line is 10 to 500 mPa.s at 6 rpm, and adding the drug solution prepared in step (2) to the automatic drinking water line at a position downstream of the liquid containing a high concentration of suspending agent being added to the automatic drinking water line by a second automatic dosing device, so that the drug is uniformly dispersed in the water medium in the drinking water line, The liquid containing the high concentration suspending agent and the liquid containing the drug are diluted in the automatic drinking water line at a ratio of 10 to 200 times, preferably 20 to 100 times.

7. A method for adding medicine to an automatic drinking water line, characterized in that: The method comprises the following steps: (1) The suspending agent composition according to any one of claims 1 to 5 is prepared into a liquid containing a high concentration of the suspending agent using water, wherein the mass content of the suspending agent is 5 to 20%, and preferably the salt substance therein is completely dissolved; (2) adding the drug to the liquid containing the high concentration suspending agent in step (1); (3) adding the drug-containing liquid prepared in step (2) to the automatic drinking water line through an automatic drug adding device, so that the viscosity of the water medium in the water line is 10 to 500 mPa.s at 6 rpm, and the drug is evenly dispersed therein, The drug-containing liquid is diluted in the automatic drinking water line by 10 to 200 times, preferably 20 to 100 times.

8. The method for adding medicine to an automatic drinking water line according to claim 6 or 7, characterized in that: The drug is selected from drugs whose liquid materials prepared at clinical use concentrations contain insoluble particles, wherein the insoluble particles are smaller than 100 μm and larger than 1 μm; Preferably, the drug is selected from coccidia oocyst vaccine, chemical suspension or feed additive.

9. The method for adding medicine to an automatic drinking water line according to claim 6 or 7, characterized in that: The drug is selected from coccidia oocyst vaccines, More preferably, the coccidia oocyst vaccine is selected from the group consisting of chicken coccidia oocyst vaccine, rabbit coccidia oocyst vaccine, pigeon coccidia oocyst vaccine, duck coccidia oocyst vaccine, goose coccidia oocyst vaccine, porcine coccidia oocyst vaccine, bovine coccidia oocyst vaccine, sheep coccidia oocyst vaccine, dog coccidia oocyst vaccine, cat coccidia oocyst vaccine, guinea pig coccidia oocyst vaccine, and / or The chemical drug suspension is selected from albendazole suspension, toltrazuril suspension, and / or The feed additive is selected from vitamin additives, trace element additives, and probiotic additives.

10. The method for adding medicine to an automatic drinking water line according to claim 6 or 7, characterized in that: The process of preparing the suspending agent composition according to any one of claims 1 to 5 into a liquid containing a high concentration of the suspending agent using water comprises the steps of: first adding the salt substance in the suspending agent composition and optionally xanthan gum or a xanthan gum composition into water, and adding the suspending agent after the salt substance and the xanthan gum composition are fully dissolved, wherein the suspending agent is selected from cellulose ether, and the weight ratio of water to the suspending agent composition is 1:3-18, or, The salt substance in the suspending agent composition and the suspending agent, and optionally xanthan gum or a xanthan gum composition, are added into water together, wherein the suspending agent is selected from a cellulose ether with delayed dissolution, and the weight ratio of water to the suspending agent composition is 1:3-18.

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