Anti-fatigue compound preparation and preparation method thereof

Abstract

The invention relates to the technical field of compound preparations, and particularly provides an anti-fatigue compound preparation and a preparation method thereof. The anti-fatigue compound preparation comprises the following components in percentage by weight: 12%-20% of rhizoma polygonati, 10%-16% of lily, 2%-7% of houttuynia cordata, 2%-6% of momordica grosvenori, 0.5%-5% of emblic leafflower fruit extract, 1%-5% of fructus alpiniae oxyphyllae, 1%-5% of platycodon grandiflorum, 5%-12% of D-mannitol and 1%-3% of magnesium stearate. 3%-7% of a compound nutrition enhancer, 0.5%-3% of endothelium corneum gigeriae galli and the balance of sorbitol. According to the anti-fatigue compound preparation, the components such as the rhizoma polygonati, the lily, the houttuynia cordata, the momordica grosvenori, the fructus alpiniae oxyphyllae, the emblic leafflower fruit, the platycodon grandiflorum and the endothelium corneum gigeriae galli powder are adopted, so that the anti-fatigue compound preparation can effectively regulate vital essence, qi and blood of a human body and has the effects of improving the fatigue state of the human body and enhancing the physical strength, and therefore, the compound preparation with the anti-fatigue effect is provided.

Description

Technical Field

[0001] The present invention relates to the technical field of compound preparations, and in particular to an anti-fatigue compound preparation. In addition, the present invention also relates to a preparation method of the anti-fatigue compound preparation. Background Art

[0002] In recent years, with the development and progress of society and the improvement of people's living standards, people's pace of life has also accelerated dramatically; the fast-paced life often makes people busy and anxious. This high-intensity, fast-paced lifestyle has caused many people to be in a state of fatigue and sub-health for a long time. This fatigue is not only reflected in physical exhaustion, such as muscle soreness and fatigue, but may even cause physical discomfort symptoms such as headaches; at the same time, it also profoundly affects people's psychological state, leading to inattention, memory loss, and even a sense of fatigue that is difficult to get rid of.

[0003] These problems not only reduce people's quality of life, but may also have a serious negative impact on work and study. Therefore, the prevention and relief of fatigue is particularly important. However, it is worth noting that fatigue, a sub-healthy state, has not yet reached the exact standard of a disease, so there is no unified and specific diagnostic standard and corresponding means in the medical field. In the face of this phenomenon, Chinese and Western medicine have different understandings and treatment methods.

[0004] In Western medicine, some drugs that can regulate the function of the nervous system and metabolic state, such as stimulants and antidepressants, are used to help patients boost their spirits and relieve fatigue. However, the use of these drugs needs to strictly follow the doctor's instructions, because improper use may cause side effects. Traditional Chinese medicine focuses on restoring physical strength by regulating the body's yin and yang balance and the circulation of qi and blood, including Chinese medicine conditioning, acupuncture, massage and Chinese medicine health care. Acupuncture and massage can stimulate meridians and acupoints, promote the circulation of qi and blood, and relieve fatigue and pain. Chinese medicine health care includes regulating diet, work and rest, and psychological state, which can help restore physical strength and improve immunity. Compared with Western medicine, medicine and food conditioning has better safety and efficacy, and is suitable for long-term use to relieve sub-health conditions. However, there is a lack of such medicine and food conditioning products on the existing market, and the method of boiling Chinese medicine according to the prescriptions prescribed by traditional Chinese medicine is difficult to meet people's requirements for easy carrying and quick taking. Summary of the invention

[0005] In view of this, the present invention aims to propose an anti-fatigue compound preparation, so as to provide a compound concentrated tablet with anti-fatigue efficacy.

[0006] To achieve the above object, the technical solution of the present invention is achieved as follows:

[0007] An anti-fatigue compound preparation comprises the following components in percentage by weight:

[0008] 12%-20% of polygonatum, 10%-16% of lily, 2%-7% of houttuynia cordata, 2%-6% of monk fruit, 0.5%-5% of emblica extract, 1%-5% of alpinia oxyphylla, 1%-5% of platycodon, 5%-12% of D-mannitol, 1%-3% of magnesium stearate, 3%-7% of compound nutrient enhancers, 0.5%-3% of chicken's gizzard lining, and the rest is sorbitol.

[0009] Furthermore, the compound nutritional enhancer includes one or more of maltodextrin, thiamine nitrate, pyridoxine hydrochloride and riboflavin.

[0010] Furthermore, the weight percentage of the polygonatum is 15%-18%, the weight percentage of the lily is 12%-15%, and the weight percentage of the D-mannitol is 6%-10%.

[0011] Furthermore, the weight percentage of the Houttuynia cordata is 4%-6%, the weight percentage of the Phyllanthus emblica extract is 2%-4%, the weight percentage of the compound nutritional enhancer is 4%-6%, and the weight percentage of the Gallus gallus domesticus is 1%-2%.

[0012] Compared with the prior art, the present invention has the following advantages:

[0013] The anti-fatigue compound preparation of the present invention adopts components such as polygonatum, lily, houttuynia cordata, momordica grosvenori, alpinia oxyphylla, emblica emblica, platycodon grandiflorum, and chicken's gizzard lining powder, can effectively regulate human essence and qi and blood, has the effects of improving human fatigue state and enhancing physical strength, thereby providing a compound concentrated tablet with anti-fatigue effect.

[0014] At the same time, the anti-fatigue compound preparation of the present invention selects the above eight medicinal and edible components, which are of few types and easy to collect. It is processed with auxiliary materials such as mannitol, magnesium stearate, compound nutritional enhancers, sorbitol, etc., and can be made into tablets that are easy to carry and take, which is suitable for the needs of people who need to improve their fatigue status.

[0015] Another object of the present invention is to provide a method for preparing the anti-fatigue compound preparation of the present invention, comprising the following steps:

[0016] S1, weighing each of the components to complete the material preparation; wherein the polygonatum, the lily, the houttuynia cordata, the momordica grosvenori, the emblica emblica extract, the Alpinia oxyphylla and the platycodon grandiflorum are used after being crushed;

[0017] S2: dry-mixing the sorbitol, the polygonatum, the lily, the D-mannitol, the houttuynia cordata, the momordica grosvenori, the alpinia oxyphylla, the emblica emblica extract, the platycodon grandiflorum and the galli gizzard lining according to a proportion, and then adding ethanol for wet granulation;

[0018] S3, drying the wet granular material obtained in step S2, and adding the compound nutritional enhancer and the magnesium stearate to mix after drying;

[0019] S4, tableting and coating the material obtained by the total mixing in step S3.

[0020] Furthermore, in the step S1, the crushed polygonatum, lily, houttuynia cordata, momordica grosvenori, emblica emblica extract, alpinia oxyphylla and platycodon grandiflorum are used after being sieved through an 80-mesh sieve, the sorbitol is a powdered raw material with a mesh size of less than 40, and the chicken's gizzard lining is chicken's gizzard lining powder.

[0021] Furthermore, in step S2, the dry mixing time is controlled to be between 2 minutes and 6 minutes; the wet granulation uses an ethanol solution with a concentration of 80% to 90%, and the amount of the ethanol solution is 32% to 40% of the total mass of each of the components.

[0022] Furthermore, in the step S3, the wet granules are dried at 55° C. to 65° C. until the moisture content reaches below 7.5%, and then the dried granulated material is sieved through a 20-mesh screen for granulation, followed by the total mixing.

[0023] Furthermore, the total mixing is carried out in a three-dimensional motion mixer, and the mixing time is controlled between 15 minutes and 30 minutes.

[0024] Furthermore, in step S4, the composite coating agent used for coating is dissolved in 50% ethanol, and the weight of the coating is controlled to be less than 5% of the weight of the tablet.

[0025] The preparation method of the present invention can be made into a compound preparation with good anti-fatigue effect through rigorous and orderly processing and preparation processes such as pulverization, mixing, granulation, drying and tablet coating; the process has good reliability and reproducibility, can achieve full mixing of various components and maintain their respective medicinal effects, and is provided for people to use in the form of tablets, meeting people's needs for convenient carrying and taking, and can effectively relieve people's fatigue. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] The accompanying drawings, which constitute part of the present invention, are used to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention. The directional terms such as front and back, up and down, etc. involved therein are only used to indicate relative positional relationships and do not constitute improper limitations on the present invention. In the accompanying drawings:

[0027] Figure 1 The present invention is a schematic diagram of the overall process flow of the method for preparing the anti-fatigue compound preparation according to an embodiment of the present invention. DETAILED DESCRIPTION

[0028] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other.

[0029] In addition, it should be noted that based on the overall formulation principle and processing flow of the present invention, the tablets of the present invention can adopt a variety of specific embodiments with different specific component contents. For example, the above-mentioned polygonatum, lily, houttuynia cordata, etc. can be reasonably adjusted within a limited ratio range, and the compound nutritional enhancer can also be flexibly selected from maltodextrin, thiamine nitrate, pyridoxine hydrochloride and riboflavin; the specific processing conditions of the tablets, the mixed delivery order of the prepared materials, etc. can also be flexibly adjusted. For the parts required for the implementation of the overall scheme but not involved in the above-mentioned overall setting, reasonable and flexible design can be made with reference to the mature setting means in the field, the actual situation during implementation, etc. The specific implementation scheme described below in this embodiment is only one of the better schemes that can be formed by the above-mentioned various combinations and their changes. In actual implementation, those skilled in the art can combine the actual situation and make flexible adjustments and improvements. Obviously, the many schemes that can be formed by the above-mentioned various specific forms of combination and its changes, as well as the specific implementation scheme of this embodiment, are all within the scope of protection of the present invention.

[0030] The present invention will be described in detail below with reference to the accompanying drawings and in conjunction with embodiments.

[0031] Example 1

[0032] The present embodiment relates to an anti-fatigue compound preparation and a preparation method thereof. The compound tablet of the present embodiment has the effects of anti-fatigue efficacy and improving immunity.

[0033] In general, the anti-fatigue compound preparation comprises the following components in percentage by weight: 12%-20% of polygonatum, 10%-16% of lily, 2%-7% of houttuynia cordata, 2%-6% of monk fruit, 0.5%-5% of emblica fruit extract, 1%-5% of alpinia oxyphylla, 1%-5% of platycodon grandiflorum, 5%-12% of D-mannitol, 1%-3% of magnesium stearate, 3%-7% of a compound nutritional enhancer, 0.5%-3% of chicken's gizzard lining, and the rest is sorbitol.

[0034] In this embodiment, the following components are specifically used in proportion by mass: polygonatum (10%), lily (10%), houttuynia cordata (5%), momordica grosvenori (5%), emblica emblica extract (5%), alpinia oxyphylla (5%), platycodon (4%), D-mannitol (5%), magnesium stearate (2%), compound nutritional enhancer (6%), chicken gizzard powder (3%), and sorbitol (38%).

[0035] like Figure 1 As shown, the preparation method of this embodiment specifically includes the following steps:

[0036] S1, crushing and sieving: crush the components such as polygonatum, lily, houttuynia cordata, momordica grosvenori, alpinia oxyphylla, emblica emblica and platycodon grandiflorum, and pass through an 80-mesh sieve; sorbitol is preferably a powdered raw material with a mesh size of less than 40, and chicken's gizzard lining can be chicken's gizzard lining powder.

[0037] S2: Weigh each component according to the ratio, and after the reviewer confirms that it is correct, label it for use; first, dry mix sorbitol, polygonatum, lily, D-mannitol, houttuynia cordata, monk fruit, alpinia oxyphylla, emblica extract, platycodon grandiflorum and chicken gizzard lining, and then add ethanol for wet granulation;

[0038] S3, drying the wet granular material obtained in step S2, and adding the compound nutrient enhancer and magnesium stearate to mix after drying;

[0039] S4, tableting and coating the material obtained by the total mixing in step S3.

[0040] Specifically, the dry mixing time can be controlled within 2 to 6 minutes, and in this embodiment, the dry mixing time is 3 minutes. The concentration of the ethanol solution used in wet granulation is 80% to 90%, and the amount of the ethanol solution is 32% to 40% of the total mass of each component; in this embodiment, 85% ethanol is added, and the amount of ethanol accounts for 35.48% of the total mass of each component (i.e., the total amount of granulated material).

[0041] In step S3, the wet granules are placed in a stainless steel plate, put into a drying oven, set at 60°C, and dried to a moisture content of ≤7.5%. The dried granulated material is sieved through a 20-mesh screen for granulation.

[0042] In step S4, dry granules and composite nutrition fortifier (selecting one or more of maltodextrin, thiamine nitrate, pyridoxine hydrochloride, riboflavin) and magnesium stearate are put into three-dimensional motion mixer for mixing for 20 minutes, and the label is hung for standby use, intermediate product inspection, product detection is carried out according to product internal control standard, and then tableting is carried out. During tableting, the total mixed granules are loaded into a tablet press for tableting, and the loading difference is checked regularly. The weight difference limit requires ±5%, and the tablet weight is 0.49g / tablet. Afterwards, for coating processing, the composite film agent is dissolved in 50% ethanol, and the weight gain of the coating is controlled to be 3% of the tablet weight, and the package is uniform to the tablet.

[0043] Through rigorous and orderly processing and preparation processes such as pulverization, mixing, granulation, drying, tableting and coating, it has good reliability and reproducibility, can achieve full mixing of the components and maintain their respective efficacy, and is available for people to use in the form of tablets, meeting people's needs for convenient carrying and taking, and can effectively relieve people's fatigue. At the same time, the preparation method of the concentrated tablet of this embodiment is simple in process, good in reproducibility, and has a high qualified rate of tablet molding.

[0044] It should be noted that in the above-mentioned preparation process, the drying temperature of the wet granules, the moisture content control of the dried materials, the mixing time of the total mixing, the process parameter control of the coating and tableting, etc., can all be flexibly set within a reasonable range. For example, the wet granules can be dried at 55°C to 65°C until the moisture content reaches less than 7.5%. The total mixing is carried out in a three-dimensional motion mixer, and the mixing time can be controlled between 15 minutes and 30 minutes. The composite coating agent used for coating is dissolved in 50% ethanol and used, and the weight of the coating is controlled to be less than 5% of the tablet weight.

[0045] Example 2

[0046] In this embodiment, the following components are specifically used in the following mass ratios:

[0047] Polygonatum sibiricum (12%), lily (11%), houttuynia cordata (7%), monk fruit (5%), emblica emblica extract (4%), alkyl oxyphylla (4%), platycodon grandiflorum (4%), D-mannitol (6%), magnesium stearate (2%), compound nutritional enhancer (6%), chicken gizzard powder (2%), sorbitol (38%).

[0048] The preparation method can refer to the settings of Example 1. Among them, the dry mixing time is 2 minutes; the concentration of the ethanol solution used in the wet granulation is 80%, and the amount of the ethanol solution is 32% of the total mass of each component. The wet granules can be dried at 55°C until the moisture content reaches 5%. The total mixing time in the three-dimensional motion mixer is controlled to be 15 minutes.

[0049] Example 3

[0050] In this embodiment, the following components are specifically used in the following mass ratios:

[0051] Polygonatum sibiricum (15%), lily (12%), houttuynia cordata (6%), monk fruit (4%), emblica emblica extract (4%), alpinia oxyphylla (3%), platycodon grandiflorum (2%), D-mannitol (7%), magnesium stearate (2%), compound nutritional enhancer (6%), chicken gizzard powder (2%), sorbitol (38%).

[0052] The preparation method is set up with reference to Example 1. The dry mixing time is 5 minutes; the concentration of the ethanol solution used in the wet granulation is 90%, and the amount of the ethanol solution is 40% of the total mass of each component. The wet granules can be dried at 65°C until the moisture content reaches 6%. The total mixing time in the three-dimensional motion mixer is controlled to be 25 minutes.

[0053] Example 4

[0054] In this embodiment, the following components are specifically used in the following mass ratios:

[0055] Polygonatum sibiricum (17%), lily (14%), houttuynia cordata (4%), monk fruit (2%), emblica emblica extract (3%), alpinia oxyphylla (4%), platycodon grandiflorum (2%), D-mannitol (8%), magnesium stearate (2%), compound nutritional enhancer (5%), chicken gizzard powder (1%), sorbitol (38%).

[0056] The preparation method is set up with reference to Example 1. Among them, some process parameters are adjusted as follows: the dry mixing time is 6 minutes; the concentration of the ethanol solution used in the wet granulation is 88%, and the amount of the ethanol solution is 38% of the total mass of each component. The wet granules can be dried at 62°C until the moisture content reaches 7.5%. The total mixing time in the three-dimensional motion mixer is controlled to be 30 minutes.

[0057] Example 5

[0058] In this embodiment, the following components are specifically used in the following mass ratios:

[0059] Polygonatum sibiricum (17%), lily (14%), houttuynia cordata (5%), monk fruit (3%), emblica emblica extract (2%), alpinia oxyphylla (3%), platycodon grandiflorum (2%), D-mannitol (8%), magnesium stearate (2%), compound nutritional enhancer (5%), chicken gizzard powder (1%), sorbitol (38%).

[0060] The preparation method of this embodiment refers to the settings of Example 3.

[0061] It should be pointed out that in the above-mentioned embodiments, although the present invention has been illustrated and described with specific implementation methods, it should be appreciated that the above-mentioned embodiments are only used to illustrate the technical solution of the present invention, rather than to limit it. A person skilled in the art should understand that the technical solution described in the above-mentioned embodiments may be modified, or some or all of the technical features therein may be replaced by equivalents without departing from the spirit and scope of the present invention. However, these modifications or replacements do not cause the essence of the corresponding technical solution to deviate from the protection scope of the technical solution disclosed in the present invention.

[0062] Based on the compound preparations generated in the above-mentioned Examples 1-5: The present invention conducts the following comparative study on the anti-fatigue effects of the compound preparations of each example.

[0063] 1. Experimental materials:

[0064] Animals: 72 healthy male SD mice, clean grade, weighing 18-22 g.

[0065] 2. Methods:

[0066] 2.1 Animal components and administration

[0067] First, 72 mice were divided into 6 groups (Example 1 Group, Example 2 Group, Example 3 Group, Example 4 Group, and blank control group), each group of mice had two cages, and each cage contained 6 mice.

[0068] 2.2 Dosage design: According to the dose conversion relationship between experimental animals and humans, the dosage of Example 1 group was prepared according to 27.7 g / kg of the crude drug group; the dosage of Example 2 group was prepared according to 25.7 g / kg of the crude drug group; the dosage of Example 3 group was prepared according to 24.8 g / kg of the crude drug group; the dosage of Example 4 group was prepared according to 23.2 g / kg of the crude drug group; the dosage of Example 4 group was prepared according to 22.1 g / kg of the crude drug group; the corresponding dosing solution was prepared with an intragastric volume of 0.1 mL / 10 g (the blank control group was given distilled water).

[0069] 2.2 Experimental method: After preliminary swimming training, the mice were weighed and divided into groups. Subsequently, the test drug was orally administered once a day according to the established dose for 12 days. After that, various indicators were measured. The specific methods are as follows.

[0070] Weight-bearing swimming test: 30 minutes after the last administration of the test substance, mice were subjected to a weight-bearing (5% body weight lead foil) swimming test at a water temperature of 25°C. The swimming time of each group of mice was recorded, and the average swimming time of each group was calculated. The results were compared with those of the blank control group for variance analysis.

[0071] Serum urea nitrogen determination: 60 minutes after swimming, blood was collected from the eyeballs and serum urea nitrogen was determined according to the requirements of the kit. The results were compared with the blank control and variance analysis was performed.

[0072] Liver glycogen determination: After blood collection, the mice were killed, the liver was dissected and 100 mg of liver was weighed according to the standard, and the liver glycogen was determined according to the requirements of the kit. The results were compared with the control group for variance analysis.

[0073] 3 Experimental results

[0074] 3.1 Determination of weight-bearing swimming time of mice

[0075] Table 1: Effects of each group on the body weight of mice

[0076] Group Initial weight(g) Final weight(g) Weight gain (g) P-value Blank control group 21.2±1.5 32.2±1.9 11.2±1.7 Example 1 20.3±1.6 31.4±2.1 10.3±1.4 P＞0.05 Example 2 21.1±1.4 32.2±2.3 10.1±1.3 P＞0.05 Example 3 20.8±1.5 31.9±2.2 11.6±1.5 P＞0.05 Example 4 20.5±1.5 30.8±1.9 10.2±1.2 P＞0.05 Example 5 21.3±1.6 31.6±1.8 11.1±1.7 P＞0.05

[0077] It can be seen from the data in Table 1 that there is no significant difference in weight gain between the mice in each group and the control group (P>0.05).

[0078] Table 2: Effects of the composition on weight-bearing swimming of mice in each group

[0079] Group Swimming time (min) P-value Blank control group 20.4±5.5 Example 1 36.7±15.8 0.047 Example 2 40.5±16.4 0.040 Example 3 48.2±15.5 0.009 Example 4 51.2±18.9 0.008 Example 5 57.2±19.5 0.006

[0080] As shown in Table 2, the weighted swimming time of mice in each group was longer than that of the control group. According to variance analysis, there was a high significance between Example 3, 4 and 5 and the blank control group (P < 0.01), and there was a certain significance between Group 1 and 2 and the control group (P < 0.05).

[0081] 3.2 Determination of serum urea nitrogen in mice

[0082] Table 3: Effect of the composition on serum urea nitrogen content in each group of mice

[0083] Group Urea nitrogen (mmol / L) P-value Blank control group 11.2±2.5 Example 1 7.95±7.5 0.047 Example 2 7.50±8.3 0.034 Example 3 6.79±9.5 0.009 Example 4 6.98±8.5 0.007 Example 5 6.50±7.5 0.005

[0084] As shown in Table 3, the serum urea nitrogen content of mice in each group was significantly lower than that of the control group. According to variance analysis, there were significant differences between Example 3, 4 and 5 groups and the blank control group (P < 0.01); there were certain significant differences between Group 1 and 2 groups and the control group (P < 0.05).

[0085] 3.3 Mouse liver glycogen determination

[0086] Table 4: Effect of the composition on the liver glycogen content of each group of mice

[0087] Group Glycogen (mg / 100g liver) P-value Blank control group 2994±478.54 Example 1 3611±983.56 0.043 Example 2 3754±695.42 0.037 Example 3 4009±789.45 0.006 Example 4 4073±784.12 0.003 Example 5 4127±812.65 0.002

[0088] As shown in Table 4, the glycogen content of each group was significantly higher than that of the control group. According to variance analysis, there were significant differences between Example 3, 4 and 5 groups and the blank control group (P < 0.01); there were also some significant differences between Group 1 and 2 groups and the control group (P < 0.05).

[0089] 4 Experimental conclusions:

[0090] After strenuous exercise such as swimming, the muscle tissues in motion experience a sharp increase in energy demand, thus breaking the energy balance they maintain in static state. The protein and amino acid metabolism, which were originally relatively stable in the resting state, began to accelerate decomposition and release amino acids in order to meet the additional energy required for muscle activity. These amino acids are further converted into urea nitrogen through deamination and release energy. At the same time, nucleotide metabolism also becomes abnormally active, and the decomposition of nucleotides in cells is accelerated, which also provides the necessary energy and metabolic intermediates for muscle activity. Under the joint action of these physiological changes, the urea nitrogen content in the blood will increase significantly. This change directly reflects the metabolic burden and energy consumption of muscle tissue after strenuous exercise. In long-term intense exercise, physical exhaustion often occurs at the same time as glycogen depletion. This phenomenon shows that the content of glycogen not only determines the duration and intensity of muscle activity, but also reflects the speed or degree of fatigue. By increasing the liver glycogen reserve, more energy is provided to the body to achieve the purpose of anti-fatigue. The present invention compares Example 1, 2, 3, 4, 5 with a blank control group and finds that our raw materials can significantly prolong the swimming time of mice, reduce the serum urea nitrogen content of fatigue mice and increase the liver glycogen content within a certain ratio.

[0091] In summary, the anti-fatigue compound preparation of the present invention adopts components such as polygonatum, lily, houttuynia, momordica grosvenori, oxyphylla, emblica emblica, platycodon grandiflorum, and chicken's gizzard powder, combined with processing and preparation processes such as crushing, mixing, granulation, drying and tablet coating, and can be made into a compound preparation with good anti-fatigue effect; the process has good reliability and reproducibility, can achieve full mixing of each component and maintain their respective effects, and is used by the crowd in the form of tablets, meeting the needs of people for carrying and taking convenience, and can effectively relieve people's fatigue state. The compound preparation of the present invention can effectively regulate human body essence and qi and blood, has the effect of improving human fatigue state and enhancing physical strength, thereby providing a compound concentrated tablet with anti-fatigue effect.

[0092] The above description is only a preferred embodiment of the present invention. The detailed explanation of the configuration, the examples of the specific structural setting forms, or the description of the assembly connection mode, etc., are all for the purpose of sufficient disclosure so that those skilled in the art can better implement the present invention, but are not intended to limit the protection scope of the present invention. Any modification, equivalent substitution, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. An anti-fatigue compound preparation, characterized in that: The composition includes the following weight percentages: 12%-20% of polygonatum, 10%-16% of lily, 2%-7% of houttuynia cordata, 2%-6% of monk fruit, 0.5%-5% of emblica extract, 1%-5% of alpinia oxyphylla, 1%-5% of platycodon, 5%-12% of D-mannitol, 1%-3% of magnesium stearate, 3%-7% of compound nutrient enhancers, 0.5%-3% of chicken's gizzard lining, and the rest is sorbitol.

2. The anti-fatigue compound preparation according to claim 1, characterized in that: The compound nutritional enhancer comprises one or more of maltodextrin, thiamine nitrate, pyridoxine hydrochloride and riboflavin.

3. The anti-fatigue compound preparation according to claim 1, characterized in that: The weight percentage of the polygonatum is 15%-18%, the weight percentage of the lily is 12%-15%, and the weight percentage of the D-mannitol is 6%-10%.

4. The anti-fatigue compound preparation according to claim 1, characterized in that: The weight percentage of the herb Houttuynia is 4%-6%, the weight percentage of the emblica extract is 2%-4%, the weight percentage of the compound nutritional enhancer is 4%-6%, and the weight percentage of the chicken's gizzard lining is 1%-2%.

5. The method for preparing the anti-fatigue compound preparation according to any one of claims 1 to 4, characterized in that: include: Weighing each of the components to complete the material preparation; wherein the polygonatum, the lily, the houttuynia cordata, the momordica grosvenori, the emblica emblica extract, the alpinia oxyphylla and the platycodon grandiflorum are used after being crushed; Dry-mix the sorbitol, the polygonatum, the lily, the D-mannitol, the houttuynia cordata, the momordica grosvenori, the alpinia oxyphylla, the emblica emblica extract, the platycodon grandiflorum and the galli gizzard lining according to a ratio, and then add ethanol for wet granulation; Drying the wet granular material obtained in step S2, and adding the compound nutritional enhancer and the magnesium stearate to mix after drying; The material after the total mixing in step S3 is subjected to tableting and coating processing.

6. The preparation method according to claim 5, characterized in that: The crushed polygonatum, lily, houttuynia cordata, momordica grosvenori, emblica emblica extract, alpinia oxyphylla and platycodon grandiflorum are used after being sieved through an 80-mesh sieve, the sorbitol is a powdered raw material with a mesh size of less than 40, and the chicken's gizzard lining is chicken's gizzard lining powder.

7. The preparation method according to claim 5, characterized in that: The dry mixing time is controlled at 2 minutes to 6 minutes; the wet granulation adopts an ethanol solution with a concentration of 80% to 90%, and the amount of the ethanol solution is 32% to 40% of the total mass of each component.

8. The preparation method according to claim 5, characterized in that: The wet granules are dried at 55° C. to 65° C. until the moisture content reaches below 7.5%, and then the dried granulated material is passed through a 20-mesh screen for granulation, followed by the total mixing.

9. The preparation method according to any one of claims 5 to 8, characterized in that: The total mixing is carried out in a three-dimensional motion mixer, and the mixing time is controlled between 15 minutes and 30 minutes.

10. The preparation method according to any one of claims 5 to 8, characterized in that: The composite coating agent used in the coating process is dissolved in 50% ethanol, and the weight of the coating is controlled to be less than 5% of the weight of the compressed tablet.

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