Method for cleaning reaction cup, mode selection method and chemiluminescence immunity analyzer

Abstract

The invention relates to the technical field of automatic equipment for in-vitro diagnosis, in particular to a method for cleaning a reaction cup, a mode selection method and a chemiluminescence immunoassay analyzer. The method for cleaning the reaction cup comprises the following steps that the first gripper is driven to move on the gripper movement axis in the linear direction, the reaction cup in a reaction cup hole in a first target is grabbed, and the cup throwing action is completed; meanwhile, the second gripper is driven to move on the gripper movement axis in the linear direction, the reaction cup in the reaction cup hole in the second target is grabbed, and the cup throwing action is completed. The reaction cups in the reaction cup holes can be cleaned through linear motion of the grippers, and the multiple grippers work separately. The problems that in the prior art, cup grabbing and cup throwing actions can be achieved only by moving cup grabbing hands for a long distance, avoiding control logic is lacked between the cup grabbing hands, position interference is prone to occurring, and the cup cleaning efficiency of an analytical instrument is affected are effectively solved.

Description

Technical Field

[0001] The present invention relates to the field of in vitro diagnostic automation equipment, and in particular to a method for cleaning a reaction cup, a mode selection method and a chemiluminescent immunoassay analyzer. Background Art

[0002] Chemiluminescent immunoassay analyzer is a highly sensitive and wide linear range detection instrument that combines chemiluminescence with the principle of immune antibody-antigen reaction. Chemiluminescent immunoassay analyzer has been widely used in quantitative detection of protein substances, hormones, tumor markers, infectious diseases and other antibody-antigen contents in human serum, and has important clinical significance and application value.

[0003] In a fully automatic chemiluminescence immunoassay analyzer, the reaction containers for samples and reagents are disposable reaction cups. The test process of adding samples, adding reagents, incubation, cleaning and separation, and light measurement is completed by the circulation of reaction cups in the instrument. Therefore, a large number of reaction cup holes are set up in each component of the analytical instrument. Before the analytical instrument is restored from shutdown to an operational state, the cup grabber component on the instrument is required to automatically empty the reaction cups remaining inside the instrument due to failure or manual debugging. That is, the cup grabber must grab and explore the hole position. If there is a cup, it will be dispatched to the cup throwing position and discarded. If there is no cup, it will continue to explore the next hole position until the cup cleaning work is completed.

[0004] However, due to the large number of reaction cup holes inside the chemiluminescence analysis instrument, and the efficiency of the cup grabber to clean the cup is limited by its own movement speed, the entire cup cleaning process takes a long time. During the cup cleaning period, the user can only wait for the process to end, which greatly reduces the efficiency of instrument production debugging and laboratory testing. For example, the patent application with publication number CN207816996U discloses: an automatic analysis device. It specifically discloses: a first cup grabber and a second cup grabber. The first cup grabber is set to have a motion trajectory passing through the cup separation position and the first front operation position. When the sample adding position is located outside the reaction disk, the motion trajectory of the first cup grabber also passes through the sample adding position. The second cup grabber is set to have a motion trajectory passing through the first rear operation position, the second rear operation position, the mixing mechanism and the magnetic separation unit. The first cup grabber is a three-dimensional mobile structure or a rotary structure, and the second cup grabber is a three-dimensional mobile structure or a rotary structure. It can be seen from this that the cup grabber in the prior art needs to move in the horizontal X-axis and Y-axis directions respectively, so as to grasp the reaction cup in the reaction cup hole and transfer it to the cup throwing position for disposal. In the above process, the cup gripper needs to move a long distance to achieve the cup gripping and cup throwing actions. Moreover, there is a lack of avoidance control logic between the two cup grippers, and position interference is prone to occur, further affecting the cup cleaning efficiency of the analytical instrument. Therefore, those skilled in the art need a new method for cleaning the reaction cup to improve the cup cleaning efficiency of the cup gripper. Summary of the invention

[0005] Therefore, the technical problem to be solved by the present invention is how to solve the problem of low cup cleaning efficiency of analytical instruments in the prior art. To this end, the present invention provides a method for cleaning a reaction cup, comprising the following steps:

[0006] The first gripper is driven to move along a straight line on the gripper movement axis to grab the reaction cup in the reaction cup hole in the first target to complete the cup throwing action; at the same time, the second gripper is driven to move along a straight line on the gripper movement axis to grab the reaction cup in the reaction cup hole in the second target to complete the cup throwing action.

[0007] Optionally, the first target includes: a first part of the positions in the incubation block; the second target includes: a second part of the positions in the incubation block;

[0008] The incubation block is driven to move linearly, and the corresponding reaction cup hole is positioned on the movement axis of the gripper, so that the mobile gripper can take or put down the reaction cup.

[0009] Optionally, the first target further includes: a sample adding plate and / or a dilution block; the second target further includes: a magnetic separation plate and / or a measuring plate;

[0010] The sample adding plate and / or the magnetic separation plate and / or the measuring plate are driven to rotate, so as to position the corresponding reaction cup holes on the movement axis of the gripper, so as to allow the moving gripper to take or put down the reaction cup;

[0011] The movable gripper at least includes: the first gripper and the second gripper.

[0012] Optionally, the mobile gripper consists of the first gripper and the second gripper;

[0013] The first part of positions and the second part of positions do not overlap each other and contain a similar number of reaction cup holes.

[0014] Optionally, the reaction cup wells of the incubation block are arranged in an array of 15 by 16 in the XY direction;

[0015] The first part of the positions includes: rows Y1 to Yn in the incubation block, and columns X1 to Xm except rows Y1 to Yn in the incubation block;

[0016] The second part of the positions includes: the Xm+1th column to the X total column except the Y1th row to the Ynth row in the incubation block.

[0017] Optionally, a first cup-throwing hole located on the movement axis of the gripper is provided between the dilution block and the incubation block; the initial position and the cup-throwing position of the first gripper are both located in the first cup-throwing hole; and / or,

[0018] The dilution block is driven to move linearly to position the corresponding reaction cup hole on the movement axis of the gripper so that the gripper can take or put down the reaction cup; and / or,

[0019] A second cup-throwing hole located on the movement axis of the gripper is provided between the magnetic separation disk and the measuring disk; the initial position and cup-throwing position of the second gripper are both located in the second cup-throwing hole.

[0020] A method for selecting a mode for cleaning a reaction cup, comprising:

[0021] Obtain an operating status record of the analysis device and determine a cup clearing mode according to the status record, wherein the operating status record includes a normal test or equipment debugging; the cup clearing mode includes the following cup clearing modes:

[0022] In the full clearing mode, the reaction cups in each reaction cup well in the magnetic separation plate, the measuring plate, the incubation block, the dilution block and the sample plate are cleared one by one;

[0023] In the random check and clear mode, the reaction cups in each reaction cup well in the magnetic separation disk, the measuring disk, the dilution block and the sample loading disk are cleared one by one; and the reaction cup wells in the incubation block are randomly checked and cleared;

[0024] The memory clearing mode clears the wells with cups recorded during the working process. The analyzer in the memory clearing mode establishes a well status table for the whole machine through software, and records whether there are reaction cups in the wells of the transfer plate, dilution mechanism, incubation block, magnetic separation plate, and optical plate during the working process; the memory clearing mode only clears the wells with reaction cups for the whole machine reset and cup clearing after a fault shutdown or manual shutdown.

[0025] Optionally, the cup cleaning mode is determined based on the operation status record, including the following options:

[0026] If the test is normal, the analysis device is controlled to enter the memory clearing mode; wherein the normal test includes: clinical test or system test;

[0027] If the equipment is debugged, the analysis equipment is controlled to enter a full cup cleaning mode or a spot check cup cleaning mode.

[0028] Optionally, the operation status record further includes: analyzing whether the device is powered off and restarted;

[0029] If the analysis equipment is powered off and restarted, the control analysis equipment directly enters the full cup clearing mode or the spot check clearing mode. Specifically, if the instrument has been powered off and restarted before clearing the cups, or has entered the whole machine debugging and basic performance process, the user target at this time is usually the production or after-sales personnel of the instrument manufacturer; in the above situation, the full clearing mode or the spot check clearing mode is used;

[0030] If the analysis device is not powered off and restarted, the control analysis device continues to obtain the operating status record of the analysis device, and determines the cup clearing mode according to the status record. Specifically, if the instrument is shut down due to a fault or the user manually shuts down the instrument but does not power off and restart the instrument during clinical testing or system testing, the user target at this time is the operator in the hospital or laboratory, and the reaction cup will not be manually added to the reaction cup hole of the instrument, and the status of each hole recorded by the software is reliable; in the above situation, the memory clearing mode is used.

[0031] Optionally, the full clear mode includes the following steps:

[0032] Step S101, the first gripper removes the cuvettes in each cuvette well in the sample adding plate and the dilution block, and the cuvettes in each cuvette well in rows Y1 to Yn in the incubation block one by one;

[0033] At the same time, the second gripper removes the cuvettes in each cuvette hole in the measuring optical disc and the magnetic separation disc one by one;

[0034] Step S102, the first gripper clears columns X1 to Xm one by one except rows Y1 to Yn in the incubation block; at the same time, the second gripper clears columns Xm+1 to X total columns one by one except rows Y1 to Yn in the incubation block;

[0035] The first gripper and the second gripper simultaneously perform the cup clearing action for each row of reaction cup wells corresponding to each other in the incubation block; and / or, in the process of clearing the cups in each row of the incubation block, the first gripper and the second gripper wait for each other to finish clearing the current reaction cup wells, and then simultaneously enter the next reaction cup wells to clean the cups; and / or, when the first gripper and the second gripper clear adjacent reaction cup wells, one of them moves to the cup throwing position to avoid; and / or, when the first gripper and the second gripper clear the cups row by row in the incubation block, the first gripper and the second gripper both complete the cup clearing action in the row, and then simultaneously enter the next row to clean the cups.

[0036] Optionally, the spot check clearing mode includes the following steps:

[0037] The first gripper removes the cuvettes in each cuvette hole in the sample adding plate and the dilution block one by one; the second gripper removes the cuvettes in each cuvette hole in the measuring plate and the magnetic separation plate one by one;

[0038] The first gripper and the second gripper adopt a combination of row-by-row cleaning and random cleaning of the incubation block, and the solution is: row-by-row cleaning of the Y1 row in the incubation block; if the gripper finds no reaction cups when clearing the cups in the previous row of the incubation block, random cleaning of the X1, Xa, and Xb wells in the current row of the incubation block is adopted; if reaction cups are found in the previous row of the incubation block, the next row is cleared entirely.

[0039] A chemiluminescent immunoassay analyzer, using the above-mentioned reaction cup cleaning method, comprises:

[0040] A first gripper and a second gripper, wherein the first gripper and the second gripper are driven to move along a straight line on a gripper movement axis; and a magnetic separation disk, a measuring disk, an incubation block, a dilution block and a sample adding disk.

[0041] The technical solution of the present invention has the following advantages:

[0042] 1. The method for cleaning a reaction cup provided by the present invention comprises the following steps: a first gripper is driven to move along a linear direction on the gripper movement axis to grab the reaction cup in the reaction cup hole in the first target to complete the cup throwing action; at the same time, a second gripper is driven to move along a linear direction on the gripper movement axis to grab the reaction cup in the reaction cup hole in the second target to complete the cup throwing action.

[0043] Compared with the prior art, the gripper needs to move along the X and Y axes in the horizontal plane. In the present invention, the first gripper and the second gripper are driven to move along the linear direction on the gripper movement axis, so as to realize the grabbing of the reaction cup in the reaction cup hole. The above-mentioned grabbing method effectively improves the efficiency of the gripper in grabbing and transferring the reaction cup. Moreover, in the present invention, the first gripper is responsible for grabbing the reaction cup of the first target, and the second gripper is responsible for grabbing the reaction cup of the second target. The above-mentioned first gripper and the second gripper are made to move independently without interfering with each other, thereby avoiding the problem of position interference between the grippers and ensuring the efficiency of cleaning the cups of the analytical instrument.

[0044] 2. The method for cleaning the reaction cup provided by the present invention, the sample adding plate and / or the magnetic separation plate and / or the optical measuring plate are driven to rotate, and the corresponding reaction cup hole is positioned on the movement axis of the gripper, so that the mobile gripper can take or put down the reaction cup;

[0045] The incubation block and / or the dilution block are driven to move linearly, so that the corresponding reaction cup holes are positioned on the movement axis of the gripper, so that the movable gripper can take or put down the reaction cup;

[0046] In the present invention, by allowing the sample adding plate, magnetic separation plate and measuring plate to rotate, the reaction cup holes on the sample adding plate, magnetic separation plate and measuring plate are moved to the position where the gripper movement axis passes in sequence, so that the gripper can clear the reaction cups in the reaction cup holes at different positions during the linear motion, effectively shortening the moving distance of the gripper and improving the cup clearing efficiency. In addition, the incubation block and the dilution block can also be driven to move in a straight line, so that the reaction cup holes on the incubation block and the dilution block are moved to the position where the gripper movement axis passes, so that the gripper can clear the reaction cups on the incubation block and the dilution block through linear motion, shortening the moving distance of the gripper and improving the cup clearing efficiency.

[0047] 3. In the method for cleaning a reaction cup provided by the present invention, the movable gripper is composed of the first gripper and the second gripper; the first part position and the second part position do not overlap with each other and contain a similar number of reaction cup holes.

[0048] In the present invention, the first gripper and the second gripper respectively grasp the reaction cups at the first part and the second part. The first part and the second part do not overlap each other and contain similar numbers of reaction cup holes, so that the workload of the first gripper and the second gripper can be similar and will not interfere with each other, thereby improving the efficiency of cleaning the reaction cups in the present invention.

[0049] 4. In the method for cleaning the reaction cup provided by the present invention, a first cup throwing hole located on the movement axis of the gripper is provided between the dilution block and the incubation block; the initial position and the cup throwing position of the first gripper are both located in the first cup throwing hole; a second cup throwing hole located on the movement axis of the gripper is provided between the magnetic separation disk and the measuring disk; the initial position and the cup throwing position of the second gripper are both located in the second cup throwing hole.

[0050] In the present invention, by setting the initial positions of the first gripper and the second gripper and the cup throwing position at the position of the cup throwing hole, the length of the moving path required by the gripper can be effectively reduced, thereby improving the cup throwing efficiency.

[0051] 5. The method for cleaning the reaction cup provided by the present invention includes: a full cleaning mode, a spot cleaning mode and a memory cleaning mode.

[0052] In the present invention, in the process of clinical testing or system detection, the instrument stops due to a fault or the user manually stops the instrument but does not power off and restart it. At this time, the user target is the operator of the hospital or laboratory. In this case, there will be no situation where reaction cups are manually added to the reaction cup holes of the instrument, and the status of each hole position recorded by the software is reliable. Therefore, the whole machine cup clearing in this scenario can adopt the above-mentioned memory clearing mode. The memory clearing mode only clears the cup positions where there are cups, avoiding the useless work of the cup grabber to grab and explore each hole position, and realizing the rapid completion of the cup cleaning process, which can effectively save the cup cleaning time and reduce the user waiting time.

[0053] In addition, if the power was turned off and restarted before clearing the cup, or if the instrument had entered the whole machine debugging or basic performance process, the user target at this time is usually the production or after-sales personnel of the instrument manufacturer. The operator may manually put the reaction cup into the machine hole due to debugging or testing needs. In the above situation, the status of each hole recorded by the software is unreliable and cannot be cleared by memory, so the full clear mode or the spot check clear mode is required. In this case, the user can also select the cup clearing mode in the software interface as needed. In addition, if the behavior of the manufacturer's production or after-sales personnel is basically controllable, and the reaction cup hole positions used for whole machine debugging and basic performance are relatively fixed, the operator can choose the spot check clearing mode to quickly clear the cup.

[0054] 6. In the method for cleaning the reaction cups provided by the present invention, during the process of cleaning the cups in each row of the incubation block, the first gripper and the second gripper wait for each other to finish cleaning the current reaction cup hole position, and then simultaneously enter the next reaction cup hole position to clean the cup. In the present invention, by setting: the first gripper and the second gripper wait for each other to finish cleaning the current reaction cup hole position, and then simultaneously enter the next reaction cup hole position to clean the cup. This can effectively ensure that the first gripper and the second gripper act synchronously, avoiding the problem of position interference between the grippers.

[0055] 7. In the method for cleaning the reaction cup provided by the present invention, when the first gripper and the second gripper clear adjacent reaction cup holes, one of the two moves to the cup throwing position to avoid. For example, when the first gripper clears the X8 column except the Y1st row to the Y3rd row in the incubation block, the second gripper moves to the first cup throwing hole to avoid. The above setting can ensure that when multiple grippers work in coordination, in the process of grabbing the reaction cups of adjacent reaction cup holes, the grippers working in coordination avoid each other to avoid position interference and malfunction.

[0056] 8. In the method for cleaning reaction cups provided by the present invention, when the first gripper and the second gripper clean the cups row by row of the incubation block, after the first gripper and the second gripper complete the cup cleaning action of the row, they simultaneously enter the next row to clean the cups. The above arrangement can effectively realize the synchronous cup throwing work of multiple grippers on each row, ensure work efficiency and avoid position interference.

[0057] 9. The method for cleaning a reaction cup provided by the present invention, wherein the random cleaning mode comprises the following steps:

[0058] The first gripper removes the cuvettes in each cuvette hole in the sample adding plate and the dilution block one by one; the second gripper removes the cuvettes in each cuvette hole in the measuring plate and the magnetic separation plate one by one;

[0059] The first gripper and the second gripper adopt a combination of row-by-row cleaning and random cleaning of the incubation block, and the solution is: row-by-row cleaning of the Y1 row in the incubation block; if the gripper finds no reaction cups when clearing the cups in the previous row of the incubation block, random cleaning of the X1, Xa, and Xb wells in the current row of the incubation block is adopted; if reaction cups are found in the previous row of the incubation block, the next row is cleared entirely.

[0060] In the present invention, the gripper cleans the cups in the first row of the incubation block row by row, and determines whether to clean the next row completely according to the cup cleaning situation. The above-mentioned spot check cup cleaning mode can effectively remove the reaction cups in the incubation block while ensuring the cup cleaning efficiency.

[0061] 10. The chemiluminescent immunoassay analyzer provided by the present invention adopts the above-mentioned method for cleaning the reaction cup of the present invention, so it has all the advantages of the method for cleaning the reaction cup of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0062] In order to more clearly illustrate the specific implementation methods of the present invention or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0063] Figure 1 A schematic diagram of the working state of the gripper grabbing the reaction cup in the incubation block of the chemiluminescent immunoassay analyzer provided by the present invention;

[0064] Figure 2 A schematic diagram of the judgment logic for selecting different cup clearing modes according to needs for the chemiluminescent immunoassay analyzer provided by the present invention.

[0065] Description of reference numerals:

[0066] 1-first gripper; 2-second gripper; 3-gripper movement axis; 4-sample adding plate; 5-dilution block; 6-incubation block; 7-magnetic separation plate; 8-measurement plate; 9-first part position; 10-second part position; 11-first throwing cup hole; 12-second throwing cup hole. DETAILED DESCRIPTION

[0067] The technical solution of the present invention will be described clearly and completely below in conjunction with the accompanying drawings. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0068] In the description of the present invention, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", etc., indicating the orientation or positional relationship, are based on the orientation or positional relationship shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", and "third" are used for descriptive purposes only, and cannot be understood as indicating or implying relative importance.

[0069] Example 1

[0070] See also Figure 1 , Figure 1 A schematic diagram of the working state of the gripper grabbing the reaction cup in the incubation block in the chemiluminescent immunoassay analyzer according to an embodiment of the present invention is shown.

[0071] The method for cleaning the reaction cup provided in this embodiment comprises the following steps:

[0072] The first gripper 1 is driven to move along a straight line on the gripper movement axis 3 to grab the reaction cup in the reaction cup hole in the first target to complete the cup throwing action; the first target includes: the sample tray 4, the dilution block 5, and the first part position 9 in the incubation block 6; the reaction cup hole position of the incubation block 6 is as follows Figure 1 The XY direction is shown as 15 times 16 array arrangement; the first part of the positions 9 includes: the Y1st row to the Y3rd row in the incubation block 6, and the X1st column to the X8th column in the incubation block 6 except the Y1st row to the Y3rd row;

[0073] At the same time, the second gripper 2 is driven to move along the gripper movement axis 3 in a straight line direction to grab the cuvette in the cuvette hole in the second target and complete the cup throwing action. The second target includes: a magnetic separation disk 7, a measuring disk 8, and a second part position 10 in the incubation block 6; the cuvette hole position of the incubation block 6 is as follows Figure 1 The XY direction is shown as a 15 times 16 array arrangement; the second part of the positions 10 includes: the X9th to X15th columns in the incubation block 6 except the Y1st to Y3rd rows.

[0074] In this embodiment, the first gripper 1 and the second gripper 2 can move in a straight line to remove the cuvettes in the sample tray 4, the magnetic separation tray 7, the measuring tray 8, and the cuvette holes on the incubation block 6 and the dilution block 5. Figure 1 As shown, the sample adding plate 4, the magnetic separation plate 7, and the measuring plate 8 are driven to rotate, and the corresponding reaction cup holes are positioned on the gripper movement axis 3, so that the mobile gripper can take or put down the reaction cup; the incubation block 6 and the dilution block 5 are driven to move linearly, and the corresponding reaction cup holes are positioned on the gripper movement axis 3, so that the mobile gripper can take or put down the reaction cup.

[0075] A first cup-throwing hole 11 located on the gripper motion axis 3 is provided between the dilution block 5 and the incubation block 6; the initial position and cup-throwing position of the first gripper 1 are both located in the first cup-throwing hole 11; a second cup-throwing hole 12 located on the gripper motion axis 3 is provided between the magnetic separation disk 7 and the measuring disk 8; the initial position and cup-throwing position of the second gripper 2 are both located in the second cup-throwing hole 12. By setting the initial position and cup-throwing position of the first gripper 1 and the second gripper 2 at the position of the cup-throwing hole, the length of the moving path required by the gripper can be effectively reduced, thereby improving the cup-throwing efficiency.

[0076] In addition, in order to achieve similar workloads of the first gripper 1 and the second gripper 2 and not interfere with each other, thereby improving the efficiency of cleaning the reaction cup in the present invention, the first part position 9 and the second part position 10 do not overlap with each other and contain a similar number of reaction cup holes. At the same time, according to the above cup cleaning area division, the two grippers are responsible for cleaning approximately the same number of reaction cup holes, avoiding the situation where one gripper is cleaning the cup, but the other gripper has finished cleaning the cup and is idle for a long time, thereby improving the overall cup cleaning speed.

[0077] In this embodiment, see Figure 2 , Figure 2 The figure shows a schematic diagram of the judgment logic of selecting different cup cleaning modes according to the needs of the chemiluminescent immunoassay analyzer in the embodiment of the present invention.

[0078] Methods for cleaning the reaction cup include:

[0079] In the full clearing mode, the reaction cups in each reaction cup hole in the magnetic separation disk 7, the measuring disk 8, the incubation block 6, the dilution block 5 and the sample adding disk 4 are cleared one by one;

[0080] In the random check and clearing mode, the cuvettes in each cuvette well in the magnetic separation disk 7, the measuring disk 8, the dilution block 5 and the sample adding disk 4 are cleared one by one; and the cuvette wells in the incubation block 6 are randomly checked and cleared;

[0081] In the memory clearing mode, the analyzer establishes a whole-machine hole status table through software, and records whether there are reaction cups in the holes of the transfer plate, dilution mechanism, incubation block 6, magnetic separation plate 7, and measurement optical plate 8 during operation; the memory clearing mode only clears the holes with reaction cups for whole-machine reset and cup clearing after a fault shutdown or manual shutdown.

[0082] If the instrument has been powered off and restarted before clearing the cup, or has entered the whole machine debugging or basic performance process, the user target at this time is usually the production or after-sales personnel of the instrument manufacturer. The operator may manually put the reaction cup into the machine hole due to debugging or testing needs. In the above situation, the status of each hole recorded by the software is unreliable and cannot be cleared by memory, so the full clear mode or spot check clear mode is required. In this case, the user can also select the cup clearing mode in the software interface as needed.

[0083] The full clear mode includes the following steps:

[0084] Step S101, the first gripper 1 removes the cuvettes in each cuvette well in the sample adding plate 4 and the dilution block 5, and the cuvettes in each cuvette well in rows Y1 to Y3 in the incubation block 6 one by one;

[0085] At the same time, the second gripper 2 removes the cuvettes in each cuvette hole in the measuring optical disc 8 and the magnetic separation disc 7 one by one;

[0086] In step S102, the first gripper 1 clears columns X1 to X8 in the incubation block 6 except rows Y1 to Y3 one by one; at the same time, the second gripper 2 clears columns X9 to X15 in the incubation block 6 except rows Y1 to Y3 one by one.

[0087] In addition, the spot check clearing mode includes the following steps:

[0088] The first gripper 1 clears the cuvettes in each cuvette hole in the sample adding plate 4 and the dilution block 5 one by one; the second gripper 2 clears the cuvettes in each cuvette hole in the measuring plate 8 and the magnetic separation plate 7 one by one;

[0089] The first gripper 1 and the second gripper 2 adopt a combination of row-by-row cleaning and random cleaning of the incubation block 6, and the solution is: row-by-row cleaning of the Y1th row in the incubation block 6; if the gripper finds that there are no reaction cups when clearing the previous row of the incubation block 6, then the current row of the incubation block 6 is cleaned by random cleaning of the X1, Xa, and Xb wells; if reaction cups are found in the previous row of the incubation block 6, the next row is cleared entirely.

[0090] In the process of cleaning the cup, the first gripper 1 and the second gripper 2 are effectively ensured to move synchronously, avoiding the problem of position interference between the grippers and improving the efficiency of cleaning the cup. The following operation logic rules are implemented in the process of cleaning the cup:

[0091] 1. The first gripper 1 and the second gripper 2 simultaneously perform the cup cleaning action for each corresponding row of reaction cup wells in the incubation block 6 .

[0092] 2. During the process of cleaning the cups in each row of the incubation block 6, the first gripper 1 and the second gripper 2 wait for each other to finish cleaning the current reaction cup hole position, and then simultaneously enter the next reaction cup hole position to clean the cup.

[0093] 3. When the first gripper 1 and the second gripper 2 clear adjacent reaction cup holes, one of them moves to the cup throwing position to avoid; for example, when the first gripper 1 clears the X8 column except the Y1 to Y3 rows in the incubation block 6, the second gripper 2 moves to the first cup throwing hole 11 to avoid.

[0094] 4. When the first gripper 1 and the second gripper 2 clean the cups row by row in the incubation block 6, after both the first gripper 1 and the second gripper 2 complete the cup cleaning action in the row, they simultaneously enter the next row to perform the cup cleaning action.

[0095] The first target includes: a first part position 9 in the incubation block 6; and, the first target also includes: a sample adding plate 4 and / or a dilution block 5;

[0096] The second target includes: a second part position 10 in the incubation block 6; and the second target also includes: a magnetic separation disk 7 and / or a measuring disk 8;

[0097] Of course, this embodiment does not specifically limit the objects included in the first target and the second target. In other embodiments, the first target includes: the first part of the positions 9 in the incubation block 6, and one of the sample adding disk 4 and the dilution block 5; the second target includes: the second part of the positions 10 in the incubation block 6, and one of the magnetic separation disk 7 and the measuring disk 8. Moreover, in this embodiment, the first target and the second target may not include the incubation block 6, and the other targets in the first target and the second target may be selected as needed, all or one of them may be selected, or none of them may be selected.

[0098] Of course, this embodiment does not specifically limit the array arrangement of the incubation blocks 6, and the specific positions of the first target and the second target. In other embodiments, the incubation blocks 6 can be arranged in an array of 18 times 18 along the XY direction, or in an array of other numbers. In addition, the system can change the specific positions of the first target and the second target corresponding to the first gripper 1 and the second gripper 2, respectively, according to the needs of the operator.

[0099] Of course, this embodiment does not specifically limit the number of grippers used to transfer reaction cups in the chemiluminescence immunoassay analyzer. In other embodiments, the chemiluminescence immunoassay analyzer is provided with three or more grippers.

[0100] Of course, this embodiment does not specifically limit the position of the cuvette holes adjacent to the first gripper 1 and the second gripper 2. In other embodiments, when the first gripper 1 and the second gripper 2 clear the adjacent cuvette holes, one of them moves to the cup throwing position to avoid. The specific position where the first gripper 1 and the second gripper 2 avoid each other can be determined according to the settings of the operator.

[0101] Of course, the present embodiment does not specifically limit the positions included in the first part of the positions 9 and the positions included in the second part of the positions 10. In other embodiments, the positions of the incubation blocks 6 included in the first part of the positions 9 can be selected in any row or column as needed. The positions of the incubation blocks 6 included in the second part of the positions 10 can also be selected in any row or column as needed.

[0102] Example 2

[0103] A chemiluminescent immunoassay analyzer adopts the method for cleaning a reaction cup disclosed in the above-mentioned embodiment 1, comprising: a first gripper 1 and a second gripper 2, wherein the first gripper 1 and the second gripper 2 are driven to move in a straight line direction on a gripper movement axis 3; and a magnetic separation disk 7, a measuring disk 8, an incubation block 6, a dilution block 5 and a sample adding disk 4.

[0104] Obviously, the above embodiments are merely examples for the purpose of clear explanation, and are not intended to limit the implementation methods. For those skilled in the art, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived therefrom are still within the scope of protection of the invention.

Claims

1. A method for cleaning a reaction cup, characterized in that: The following steps are involved: The cup is cleaned by a movable gripper, the movable gripper comprising at least: a first gripper (1) and a second gripper (2); The first gripper (1) is driven to move along a straight line on a gripper movement axis (3) to grab a reaction cup in a reaction cup hole in a first target, thereby completing a cup throwing action; at the same time, the second gripper (2) is driven to move along a straight line on a gripper movement axis (3) to grab a reaction cup in a reaction cup hole in a second target, thereby completing a cup throwing action.

2. The method for cleaning a reaction cup according to claim 1, characterized in that: The first target includes: a first partial position (9) in the incubation block (6); the second target includes: a second partial position (10) in the incubation block (6); The incubation block (6) is driven to move linearly, positioning the corresponding reaction cup hole on the gripper movement axis (3) for the mobile gripper to take or put down the reaction cup.

3. The method for cleaning a reaction cup according to claim 2, characterized in that: The first target further comprises: a sample adding plate (4) and / or a dilution block (5); the second target further comprises: a magnetic separation plate (7) and / or a measuring plate (8); the sample adding plate (4) and / or the magnetic separation plate (7) and / or the measuring plate (8) are driven to rotate, so as to position the corresponding reaction cup holes on the gripper movement axis (3) so as to allow the moving gripper to take or put down the reaction cup.

4. The method for cleaning a reaction cup according to claim 2, characterized in that: The movable gripper is composed of the first gripper (1) and the second gripper (2); the first partial position (9) and the second partial position (10) do not overlap each other and contain a similar number of reaction cup holes; and / or, The first part of the positions (9) includes: rows Y1 to Yn in the incubation block (6), and columns X1 to Xm in the incubation block (6) except rows Y1 to Yn; wherein the first part of the positions (9) is close to the measuring optical disc (8); The second part of the positions (10) includes: the Xm+1th column to the Xth column in the incubation block (6) except the Y1th row to the Ynth row; wherein the second part of the positions (10) is close to the dilution block (5).

5. The method for cleaning a reaction cup according to claim 3, characterized in that: A first cup-throwing hole (11) located on the gripper movement axis (3) is provided between the dilution block (5) and the incubation block (6); the initial position and cup-throwing position of the first gripper (1) are both located in the first cup-throwing hole (11); and / or, A second cup-throwing hole (12) located on the gripper movement axis (3) is provided between the magnetic separation disk (7) and the optical measuring disk (8); the initial position and cup-throwing position of the second gripper (2) are both located in the second cup-throwing hole (12).

6. A method for selecting a mode for cleaning a reaction cup, characterized in that: include: Obtain an operating status record of the analysis device and determine a cup clearing mode according to the status record, wherein the operating status record includes a normal test or equipment debugging; the cup clearing mode includes the following cup clearing modes: In the full clearing mode, the reaction cups in the reaction cup holes in the magnetic separation disk (7) and / or the measuring disk (8) and / or the incubation block (6) and / or the dilution block (5) and / or the sample adding disk (4) are cleared one by one; In the random check and clearing mode, the reaction cups in the reaction cup wells of the magnetic separation disk (7) and / or the measuring disk (8) and / or the dilution block (5) and / or the sample adding disk (4) are cleared one by one; and / or, the reaction cup wells in the incubation block (6) are randomly checked and cleared; Memory clear mode clears the cup hole positions recorded during the working process.

7. The method for selecting a mode for cleaning a reaction cup according to claim 6, characterized in that: Determine the cup cleaning mode based on the operation status record. Includes the following options: If the test is normal, the analysis device is controlled to enter the memory clearing mode; wherein the normal test includes: clinical test or system test; If the equipment is debugged, the analysis equipment is controlled to enter a full cup cleaning mode or a spot check cup cleaning mode.

8. The method for selecting a mode for cleaning a reaction cup according to claim 6 or 7, characterized in that: The operation status record also includes: analyzing whether the device is powered off and restarted; If the analysis equipment is powered off and restarted, the control analysis equipment directly enters the full cup cleaning mode or the spot check cup cleaning mode; If the analysis device is not powered off and restarted, the analysis device is controlled to continue to obtain the operation status record of the analysis device, and the cup cleaning mode is determined according to the status record.

9. The method for selecting a mode for cleaning a reaction cup according to claim 6, characterized in that: The full clear mode includes the following steps: Step S101, the first gripper (1) removes the cuvettes in each cuvette well in the sample loading plate (4) and the dilution block (5), and the cuvettes in each cuvette well in rows Y1 to Yn in the incubation block (6) one by one; At the same time, the second gripper (2) removes the cuvettes in each cuvette hole in the measuring optical disc (8) and the magnetic separation disc (7) one by one; Step S102, the first gripper (1) clears columns X1 to Xm one by one except rows Y1 to Yn in the incubation block (6); at the same time, the second gripper (2) clears columns Xm+1 to X total columns one by one except rows Y1 to Yn in the incubation block (6); The first gripper (1) and the second gripper (2) perform the cup clearing action for each row of reaction cup holes corresponding to each other in the incubation block (6) simultaneously; and / or, during the cup clearing process of each row of the incubation block (6), the first gripper (1) and the second gripper (2) wait for each other to finish clearing the current reaction cup hole, and then simultaneously enter the next reaction cup hole to clean the cup; and / or, when the first gripper (1) and the second gripper (2) clear adjacent reaction cup holes, one of them moves to the cup throwing position to avoid; and / or, during the cup clearing process of the incubation block (6) row by row by the first gripper (1) and the second gripper (2), after the first gripper (1) and the second gripper (2) both complete the cup clearing action of the row, they simultaneously enter the next row to clean the cup.

10. The method for selecting a mode for cleaning a reaction cup according to claim 6, characterized in that: The spot check clearing mode comprises the following steps: The first gripper (1) removes the cuvettes in each cuvette hole in the sample adding plate (4) and the dilution block (5) one by one; the second gripper (2) removes the cuvettes in each cuvette hole in the measuring plate (8) and the magnetic separation plate (7) one by one; The first gripper (1) and the second gripper (2) use a combination of row-by-row cleaning and random cleaning of the incubation block (6), and the solution is: row-by-row cleaning of the Y1th row in the incubation block (6); if the gripper finds that there are no reaction cups when cleaning the previous row of the incubation block (6), then the X1th, Xath, and Xbth wells of the current row of the incubation block (6) are cleaned by random checking; if reaction cups are found in the previous row of the incubation block (6), the next row is cleared.

11. The method for selecting a mode for cleaning a reaction cup according to claim 6, characterized in that: A method for cleaning a reaction cup using any one of claims 1 to 5.

12. A chemiluminescent immunoassay analyzer, using the method for cleaning a reaction cup according to any one of claims 1 to 5, characterized in that: include: A first gripper (1) and a second gripper (2), wherein the first gripper (1) and the second gripper (2) are driven to move in a straight line direction on a gripper movement axis (3); and a magnetic separation disk (7), a measuring disk (8), an incubation block (6), a dilution block (5) and a sample addition disk (4).

Images