Preparation method of artemisia dubia oil soft capsule

Abstract

The invention discloses a preparation method of an artemisia dubia oil soft capsule, and relates to the technical field of medicine preparation. Comprising a content and a capsule shell, the content comprises artemisia dubia oil, vegetable oil and a dispersion medium, the weight ratio of the artemisia dubia oil to the vegetable oil serving as the dispersion medium is 1: (1-2), the vegetable oil serving as the dispersion medium in the content is corn oil and soybean oil, and the preferable weight ratio of the artemisia dubia oil to the dispersion medium is 1: 1.5. The artemisia dubia oil and the specific vegetable oil are mixed according to a certain proportion to serve as a dispersion medium, so that the dispersion uniformity of the artemisia dubia oil in the soft capsule is effectively improved, the solubility of the artemisia dubia oil is also improved, effective components in the soft capsule are more easily absorbed and utilized by a human body, and the soft capsule has a good application prospect. The specific vegetable oil has certain oxidation resistance, and the vegetable oil serving as a dispersion medium can further enhance the oxidation resistance of the artemisia dubia oil, so that the storage life of effective components in the soft capsule is prolonged, and oxidative deterioration of the effective components in the soft capsule in the storage process is prevented.

Description

Technical Field

[0001] The invention relates to the technical field of medicine preparation, in particular to a method for preparing oxtail wormwood oil soft capsules. Background Art

[0002] Oxtail Artemisia Oil Capsules have the effects of resolving phlegm and relieving cough, lowering qi and relieving asthma. They are used for patients with phlegm blocking the lungs, asthma and cough, and excessive sputum, as well as chronic bronchitis with the above symptoms. It is a commonly used oral preparation for clinical and home treatment of chronic bronchitis.

[0003] Most soft capsules mainly use fish oil, vitamins, etc. as fillers to improve cardiovascular health or supplement nutrition. However, for Artemisia selengensis oil with specific pharmacological activity, the existing technology lacks effective encapsulation and utilization methods, resulting in uneven dispersion, poor solubility, and weak antioxidant properties when it is directly used for soft capsule filling, affecting its application range and effects. Furthermore, the capsule shell materials and formulas currently used for Artemisia selengensis oil filling fail to provide optimal protection and stability, thereby limiting the shelf life of the product and the patient's taking experience. Summary of the invention

[0004] The object of the present invention is to provide a method for preparing oxtail wormwood oil soft capsules to solve the problems raised in the above background technology.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical scheme: a method for preparing oxtail artemisia oil soft capsules, comprising contents and capsule shells, wherein the contents comprise oxtail artemisia oil, vegetable oil and a dispersion medium, the weight ratio of the oxtail artemisia oil to the vegetable oil as a dispersion medium is 1:1-2, the vegetable oil of the dispersion medium in the contents is corn oil and soybean oil, and the preferred weight ratio of the oxtail artemisia oil to the dispersion medium is 1:1.5.

[0006] As a specific solution of the technical solution of the present application, the content is further added with a lubricant and a suspending agent at a weight ratio of 2%, respectively. The lubricant is the surfactant Span 80, and the suspending agent is beeswax.

[0007] As a specific solution of the technical solution of the present application, the dried Artemisia selengensis medicinal material is crushed, Artemisia selengensis oil is extracted by steam distillation, and the volatile oil obtained by distillation is collected;

[0008] The extracted Artemisia selengensis oil is uniformly mixed with the vegetable oil as a dispersion medium in a ratio of 1:1-2 to obtain a content.

[0009] As a specific scheme of the technical solution of the present application, the capsule shell is made by mixing gelatin, water, glycerin and titanium dioxide in proportion, with 100g of gelatin, 120g of water, 40g of glycerin and 0.1g of titanium dioxide. The mixture is repeatedly ground with a colloid mill and filtered through a 60-120 mesh sieve to form a soft capsule shell.

[0010] As a specific solution of the technical solution of the present application, the prepared contents are injected into the soft capsule shell, the soft capsule is sealed and formed by pressing with a soft capsule machine, and the filled soft capsule is dried to obtain the Artemisia annua oil soft capsule.

[0011] As a specific solution of the technical solution of the present application, the capsule shell mixture is preferably screened to a mesh size of 80-100.

[0012] As a specific solution of the technical solution of the present application, the preferred ratio of water to gelatin is 1:1.

[0013] Compared with the prior art, the present invention has the following beneficial effects:

[0014] The method for preparing the oxtail wormwood oil soft capsule effectively improves the dispersion uniformity of the oxtail wormwood oil in the soft capsule by mixing the oxtail wormwood oil and a specific vegetable oil in a certain proportion as a dispersion medium, and also improves the solubility of the oxtail wormwood oil, so that the effective ingredients in the soft capsule are more easily absorbed and utilized by the human body. The specific vegetable oil itself has certain antioxidant properties, and the vegetable oil as a dispersion medium can further enhance the antioxidant property of the oxtail wormwood oil, which helps to prolong the shelf life of the effective ingredients in the soft capsule and prevent them from oxidative deterioration during storage. DETAILED DESCRIPTION

[0015] The invention provides a technical solution: a method for preparing an oxtail wormwood oil soft capsule, comprising contents and a capsule shell, wherein the contents comprise oxtail wormwood oil, vegetable oil and a dispersion medium, the weight ratio of the oxtail wormwood oil to the vegetable oil as a dispersion medium is 1:1-2, the vegetable oil of the dispersion medium in the contents is corn oil and soybean oil, and the preferred weight ratio of the oxtail wormwood oil to the dispersion medium is 1:1.5.

[0016] The content is further added with a lubricant and a suspending agent at a weight ratio of 2%, the lubricant is a surfactant Span 80, and the suspending agent is beeswax. The dried Artemisia selengensis medicinal material is crushed, Artemisia selengensis oil is extracted by steam distillation, and the volatile oil obtained by distillation is collected; the extracted Artemisia selengensis oil is evenly mixed with the vegetable oil as a dispersion medium in a ratio of 1:1-2 to obtain the content.

[0017] The capsule shell is made by mixing gelatin, water, glycerin and titanium dioxide in proportion, wherein the gelatin is 100g, the water is 120g, the glycerin is 40g, and the titanium dioxide is 0.1g. The mixture is repeatedly ground with a colloid mill and filtered through a 60-120 mesh sieve to form a soft capsule shell. The prepared contents are injected into the soft capsule shell, and the soft capsule is sealed and formed by pressing a soft capsule machine. The filled soft capsule is dried to obtain an oxtail wormwood oil soft capsule. The capsule shell mixture is preferably sieved with 80-100 meshes. The preferred ratio of water to gelatin is 1:1.

[0018] It should be clear that in the embodiments of the present application, the crushed Artemisia selengensis medicinal material is first loaded into a distillation kettle and heated by water vapor so that water and the essential oil components in the Artemisia selengensis are evaporated together. The boiling point of the distillation is 150-300 degrees Celsius. During the distillation process, the heating should be slow and maintained for 0.5-1 hour at the beginning of the distillation to ensure the full release of the essential oil components. Then, the heat source is gradually increased according to the needs of the distillation to maintain the normal distillation speed. 10-15 minutes before the end of the distillation, the firepower or steam volume is increased to distill out the remaining essential oil in the raw material as much as possible. The evaporated essential oil and water vapor mixture is condensed through a condenser, and the water-oil mixture obtained after condensation needs to be separated to collect pure Artemisia selengensis oil.

[0019] In the present invention, we selected corn oil and soybean oil as dispersion media, and through experimental comparison, determined that the weight ratio of Artemisia selengensis oil to vegetable oil is 1:1-2, preferably 1:1.5. The specific experimental results are shown in the following table:

[0020] Drug powder: corn oil Liquidity Pellet pressing Packing volume (g / tablet) 1:1 Thick glue, poor fluidity Easy to clog and cause large losses 0.48 1:1.5 Moderate, good fluidity Smooth pill pressing 0.60 1:2 Thinner, good fluidity Smooth pill pressing 0.72

[0021] In order to improve the stability of the soft capsule, the present invention selects a lubricant and a suspending agent, wherein the lubricant is a surfactant Span 80 and the suspending agent is beeswax, and the two are combined in a ratio of 2%:2% of the total weight of the content, which effectively increases the stability of the soft capsule.

[0022] The capsule shell is composed of gelatin, glycerin, water and titanium dioxide. The ratio of gelatin to glycerin has a decisive influence on the hardness of the capsule shell. It has been found through experiments that the ratio of gelatin: water: glycerin: titanium dioxide = 1:1:0.4:0.01 can produce a capsule shell with a joint appearance and moderate hardness and softness, and the disintegration time is about 15 minutes. The specific experimental results are shown in the following table:

[0023] Gelatin: Water: Glycerin: Titanium Dioxide Shell appearance and physical properties Disintegration time (minutes) 1:1:0.3:0.01 Too hard, the capsule shell is fragile 11 1:1:0.4:0.01 Smooth appearance, moderate hardness and softness 15 1:1:0.5:0.01 Too soft, easy to stick 14 1:1:0.6:0.01 Too soft, poor finish, easy to stick 12 1:1:0.7:0.01 Too soft, poor finish, easy to stick 11

[0024] Embodiment 1: the preparation of oxtail wormwood oil soft capsule is as follows:

[0025] Take 2.5g of dried Artemisia selengensis medicinal material, crush it to pass through a 100-mesh sieve, extract Artemisia selengensis oil by steam distillation, and collect the volatile oil obtained by distillation. It should be noted that the pre-cooking temperature is 180 degrees Celsius, the pre-cooking time is 120 minutes, and it needs to be stirred every 20 minutes;

[0026] The extracted Artemisia selengensis oil and corn oil are mixed evenly in a ratio of 1:1.5 to obtain the contents, and then the contents are mixed in a ratio of gelatin: water: glycerol: titanium dioxide = 1:1:0.4:0.01 to form a capsule shell. The specific amount is 100g of gelatin, 120g of water, 40g of glycerol, and 0.1g of titanium dioxide. The mixture is repeatedly ground with a colloid mill and filtered through an 80-100 mesh sieve to form a soft capsule shell;

[0027] The prepared contents are injected into the soft capsule shell, and the soft capsule is sealed and formed by pressing with a soft capsule machine. The filled soft capsule is dried at a drying temperature of 25 degrees Celsius and a relative air humidity of 20% to ensure the quality stability of the soft capsule.

[0028] Example 2: The preparation of oxtail wormwood oil soft capsules is as follows:

[0029] Take 2.5 kg of Artemisia oxtaili medicinal material, decoct and filter twice, the first decoction temperature is 180 degrees Celsius, the time is 120 minutes; the second decoction temperature is 180 degrees Celsius, the time is 30 minutes;

[0030] The medicinal liquids obtained from the two decoctions are collected, combined, stirred and concentrated. When the density of the medicinal liquid reaches above 1.04 g / ml, the concentration is completed to obtain an extract;

[0031] The extract and soybean oil are mixed evenly in a ratio of 1:1 to obtain the contents, so as to ensure the content stability and disintegration performance of the soft capsule;

[0032] The capsule shell is prepared by mixing gelatin: water: glycerol in a ratio of 1:0.3:0.925, and the thickness of the soft capsule shell ranges from 0.2 to 0.3 mm;

[0033] The prepared contents are injected into the soft capsule shell, and the soft capsule is sealed and formed by pressing with a soft capsule machine. The filled soft capsule is then dried at a drying temperature of 25 degrees Celsius and a relative air humidity of 20% to ensure the quality stability of the soft capsule.

[0034] It should be clear that in the examples of the present application, the soft capsule production temperature is controlled at 22-25 degrees Celsius and the relative humidity of the air is 35% to ensure the quality of the capsule shell and the molding effect of the soft capsule.

[0035] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is limited by the attached embodiments and their equivalents.

Claims

1. A method for preparing an Artemisia oxtail oil soft capsule, comprising contents and a capsule shell, characterized in that: The contents include oxtail wormwood oil, vegetable oil and a dispersion medium, wherein the weight ratio of the oxtail wormwood oil to the vegetable oil as a dispersion medium is 1:1-2, the vegetable oil of the dispersion medium in the contents is corn oil and soybean oil, and the preferred weight ratio of the oxtail wormwood oil to the dispersion medium is 1:1.

5.

2. The method for preparing the Artemisia oxtail oil soft capsule according to claim 1, characterized in that: The contents are further added with 2% by weight of a lubricant and a suspending agent, wherein the lubricant is surfactant Span 80 and the suspending agent is beeswax.

3. The method for preparing the Artemisia oxtail oil soft capsule according to claim 1, characterized in that: The dried Artemisia selengensis medicinal material is crushed, Artemisia selengensis oil is extracted by steam distillation, and the volatile oil obtained by distillation is collected; The extracted Artemisia selengensis oil is uniformly mixed with the vegetable oil as a dispersion medium in a ratio of 1:1-2 to obtain a content.

4. The method for preparing the Artemisia annua oil soft capsule according to claim 1, characterized in that: The capsule shell is prepared by mixing gelatin, water, glycerin and titanium dioxide in proportion, wherein the gelatin is 100g, the water is 120g, the glycerin is 40g and the titanium dioxide is 0.1g. The mixture is repeatedly ground with a colloid mill and filtered through a 60-120 mesh sieve to form a soft capsule shell.

5. The method for preparing the Artemisia annua oil soft capsule according to claim 1, characterized in that: The prepared contents are injected into the soft capsule shell, the soft capsule is sealed and formed by pressing with a soft capsule machine, and the filled soft capsule is dried to obtain the oxtail wormwood oil soft capsule.

6. The method for preparing the Artemisia annua oil soft capsule according to claim 4, characterized in that: The capsule shell mixture is preferably sieved to a mesh size of 80-100 meshes.

7. The method for preparing the Artemisia annua oil soft capsule according to claim 4, characterized in that: The preferred ratio of water to gelatin is 1:1.