Silica gel scar patch and preparation method thereof

Abstract

According to the silica gel scar patch and the preparation method, the silica gel scar patch has good antibacterial performance, anti-inflammatory performance and relieving performance, bacterium breeding of the scar part can be effectively inhibited, the infection risk is reduced, cleaning and healing of scars are promoted, uncomfortable symptoms such as pruritus and pain of the scar part are relieved, and the silica gel scar patch has the good application prospect. And the use comfort of the patient is improved. In addition, the silica gel scar patch also has good elasticity, can stretch and deform along with the movement of the skin, does not cause oppression or discomfort to the skin, and is suitable for scars of various parts. The silica gel scar patch has excellent air permeability and comfort level, can effectively promote scar repair, improve scar appearance and relieve scar itching, pain and other symptoms, and is suitable for various types of scars such as operation scars, burn scars and wound scars.

Description

Technical Field

[0001] The invention belongs to the technical field of medical devices and relates to a silicone gel scar patch and a preparation method thereof. Background Art

[0002] Scars are formed when physical, biological, chemical and other factors damage the skin and soft tissues of the human body, causing them to be severely damaged and unable to repair themselves normally, and are replaced by fibrous tissues. Scars not only affect the appearance, but also bring great physical and mental pain to patients, and also cause functional impairment due to atrophy.

[0003] In terms of scar treatment, traditional treatment methods include pressure therapy, drug therapy, surgical treatment and medical aesthetic measures, etc. Scar patch, as a common scar intervention method, provides a physical barrier on the surface of the healed wound to keep the scar moist and clean, which helps to improve the overall condition of the scar.

[0004] The scar patches commonly seen on the market are mainly made of silicone gel, which has good moisturizing and breathable properties and can avoid the pain caused by dry scars. However, existing silicone gel scar patches have some problems during use, such as easy breeding of bacteria when exposed to water and low protective properties, which affect the healing of scars. In addition, after a period of use, silicone gel patches adhere tightly to the skin and are likely to cause pain to patients when torn off. These limitations have prompted researchers to continuously explore and improve the materials and structures of scar patches to improve their efficacy and comfort. Summary of the invention

[0005] The purpose of the present invention is to provide a silicone gel scar patch and a preparation method thereof, so as to solve the problem that the existing silicone gel scar patch has poor antibacterial property.

[0006] To achieve the above object, the present invention adopts the following technical solutions: The present application provides a silicone gel scar patch, comprising a silicone gel layer, which is a two-component addition-type room temperature vulcanized silicone rubber. Specifically, the silicone gel layer is composed of component A, component B, tea tree essential oil, chamomile essential oil and frankincense essential oil. Among them, the raw materials for preparing component A include silicon dioxide, vinyl silicone oil, methyl silicone oil and platinum complex, and the raw materials for preparing component B include silicon dioxide, vinyl silicone oil, methyl silicone oil and hydrogen-containing silicone oil.

[0007] In this application, the functions of the above-mentioned raw materials in the silicone gel scar patch are: Component A: It is formed by mixing silicon dioxide, vinyl silicone oil, methyl silicone oil and platinum complex. Among them, vinyl silicone oil includes one or more of terminal vinyl silicone oil, high vinyl silicone oil and low volatility vinyl silicone oil, such as terminal vinyl polydimethylsiloxane, terminal vinyl polymethylvinylsiloxane, etc. Methyl silicone oil includes one or more of linear methyl silicone oil, branched methyl silicone oil and cyclic methyl silicone oil, such as JG-2107 methyl branched silicone oil, DY-V411 vinyl silicone oil, cyclic dimethyl silicone oil, etc. The platinum complex is 1,3-divinyl-1,1,3,3-tetramethyldisiloxane platinum complex, that is, platinum (0)-1,3-divinyl-1,1,3,3-tetramethyldisiloxane.

[0008] Component B: It is formed by mixing silicon dioxide, vinyl silicone oil, methyl silicone oil and hydrogen-containing silicone oil. Among them, vinyl silicone oil includes one or more of terminal vinyl silicone oil, high vinyl silicone oil and low volatility vinyl silicone oil. Methyl silicone oil includes one or more of linear methyl silicone oil, branched methyl silicone oil and cyclic methyl silicone oil. Hydrogen-containing silicone oil includes one or more of polydimethylmethylhydrogensiloxane, low hydrogen-containing side hydrogen-containing silicone oil and high hydrogen-containing side hydrogen-containing silicone oil, such as 202 low hydrogen-containing silicone oil, methyl hydrogen-containing linking silicone oil, etc.

[0009] Silica: Mainly nano-silica, the particle size is usually between 20 and 35 nanometers. This small particle size allows silica to be evenly dispersed in the scar patch and give full play to its role. Nano-silica can form a microporous structure in the scar patch, which is conducive to increasing the breathability of the scar patch and ensuring the normal breathing of the skin. This is very important for the comfort and healing environment of the scar area, avoiding skin discomfort and infection risks caused by long-term closure. Nano-silica has a certain antibacterial effect and can effectively inhibit the growth of bacteria in the scar area. This is very important for preventing scar infection and promoting clean healing of scars. The addition of nano-silica can improve the tensile strength and stickiness of the scar patch. This makes the scar patch more stable during use, not easy to break or fall off due to external forces, and can better fit the scar area to provide a continuous therapeutic effect.

[0010] Vinyl silicone oil: Vinyl silicone oil and hydrogen-containing silicone oil are cross-linked through a silylation reaction to form silicone gel. This cross-linked structure gives the scar patch good elasticity and adhesion, allowing it to fit tightly on the surface of the scar and provide a sustained therapeutic effect. The addition of vinyl silicone oil can increase the tensile strength and stickiness of the scar patch, making it more stable during use and less likely to break or fall off due to external forces. As one of the main components of silicone gel, vinyl silicone oil can inhibit the excessive proliferation of fibroblasts and collagen synthesis, which is very important for reducing the thickness of scars and improving the appearance of scars.

[0011] Methyl silicone oil: Methyl silicone oil has excellent moisturizing properties, which can keep the scar area moist and prevent the scar from drying out. This moisturizing effect helps soften scar tissue and promote scar absorption and healing. Methyl silicone oil helps other ingredients in silicone gel, such as low molecular weight silicone oil, to better penetrate into scar tissue. This penetration effect can more effectively deliver therapeutic ingredients to scar tissue, playing its role in softening scars and promoting epithelial cell regeneration. In scar patches, methyl silicone oil forms a protective film that isolates the scar area from the external environment, preventing external friction, pollution and bacterial invasion, and reducing the risk of scar infection.

[0012] Hydrogenated silicone oil: Hydrogenated silicone oil is a colorless and transparent liquid, mainly formed by the reaction of organic silicon compounds containing hydrogen atoms and silicon hydrogen compounds. Its molecular structure contains active Si-H bonds, so it can participate in a variety of chemical reactions. Hydrogenated silicone oil plays a key role in scar patches. Through multiple mechanisms such as cross-linking to form a silicone gel structure, promoting scar repair, improving comfort, and protecting scar sites, it provides strong support for the treatment and repair of scars.

[0013] Platinum complex: Platinum complex is a compound formed by platinum metal and organic ligands. In the preparation of scar patches, platinum complexes can catalyze the hydrosilylation reaction between vinyl silicone oil and hydrogen-containing silicone oil, promoting the formation of silicone gel. Through effective catalysis, platinum complexes help to form a uniform silicone gel structure, ensuring the quality and performance consistency of scar patches. In addition, platinum complexes can also reduce reaction temperature and shorten reaction time, thereby improving the production efficiency of scar patches. This makes the production process of scar patches more efficient and reduces production costs.

[0014] Tea tree essential oil: Tea tree essential oil is an extract of tea tree, which has strong antibacterial ability. Its main ingredients such as terpinene-4-ol can destroy the cell membrane structure of bacteria and leak out the substances in the cells, thereby inhibiting the growth and reproduction of bacteria, effectively preventing inflammation caused by bacterial infection in the scar area, reducing the risk of infection, creating a clean environment for scar repair, and helping to avoid problems such as scar aggravation or hyperplasia caused by infection. Tea tree essential oil can also reduce itching and scratching behaviors by regulating the sensitivity of skin nerve endings. For pigmented scars that have already formed, tea tree essential oil can promote skin metabolism, accelerate the metabolism and discharge of melanin, make the color of scars gradually lighter, close to normal skin color, and play a certain role in diluting scar pigments. The secondary damage caused to scars makes patients feel more comfortable during the scar healing process.

[0015] Chamomile essential oil: Chamomile essential oil is a dark blue, viscous liquid extracted from chamomile flowers. Chamomile essential oil is rich in ingredients such as chamomile blue, which have significant anti-inflammatory properties and can effectively inhibit the release of inflammatory mediators and reduce the inflammatory response in the scar area. For scars formed by trauma, surgery and other reasons, chamomile essential oil can relieve local inflammatory symptoms such as redness, swelling, heat and pain, reduce the risk of infection, create a good internal environment for the normal repair of scars, and prevent scar hyperplasia or deterioration due to excessive inflammation. Chamomile essential oil has a certain anti-allergic effect, which can prevent and relieve skin allergic reactions that may be caused during the use of scar patches. Chamomile essential oil can also enhance the skin's tolerance, reduce the chance of skin allergies to scar patch materials or other external stimuli, and enable scar patches to fit the skin more safely and comfortably, ensuring the smooth progress of the scar repair process.

[0016] Frankincense essential oil: Frankincense essential oil is an essential oil extracted from frankincense resin. It has significant anti-inflammatory ability and can effectively reduce the inflammatory response in the scar area. Frankincense essential oil can significantly reduce the levels of IP-10 (interferon-induced protein 10) and ICAM-1 (intercellular adhesion molecule-1), which are important pro-inflammatory biomarkers. By reducing inflammation, frankincense essential oil helps relieve the symptoms of redness, swelling, pain, etc. caused by scars, and creates a good environment for scar repair. Frankincense essential oil can accelerate the healing process of the skin. It can stimulate the regeneration of skin cells and promote the synthesis of collagen, thereby speeding up the repair of scar areas. This healing effect helps reduce the formation of scars and restore the skin to normal faster.

[0017] In the present application, the raw materials for the preparation of the silicone gel layer include 30-60 parts of component A, 40-70 parts of component B, 1-5 parts of tea tree essential oil, 0.5-5 parts of chamomile essential oil and 0.5-3 parts of frankincense essential oil in parts by weight. More preferably, the raw materials for the preparation of the silicone gel layer include 30-55 parts of component A, 40-65 parts of component B, 1-5 parts of tea tree essential oil, 0.5-3 parts of chamomile essential oil and 0.5-3 parts of frankincense essential oil in parts by weight. More preferably, the raw materials for the preparation of the silicone gel layer include 30-50 parts of component A, 45-65 parts of component B, 1-3 parts of tea tree essential oil, 1-3 parts of chamomile essential oil and 0.5-2 parts of frankincense essential oil in parts by weight.

[0018] In addition, the silicone gel scar patch in the present application also includes a protective layer and a release layer located on both sides of the silicone gel layer, wherein the protective layer is a polyurethane film and the release layer is a polyethylene film.

[0019] The present application also provides a method for preparing a silicone gel scar patch, the method comprising: S01: After tea tree essential oil, chamomile essential oil and frankincense essential oil are mixed evenly, add component A and component B and mix evenly to form a silicone gel mixture.

[0020] Place tea tree essential oil, chamomile essential oil and frankincense essential oil in a stirring bucket, stir well, then add component A and component B in sequence, stir evenly with an electric stirring rod to form a silicone gel mixture. The stirring speed is 100-200r / min and the stirring time is 10-40min. Preferably, the stirring speed is 100-170r / min and the stirring time is 10-25min. More preferably, the stirring speed is 120-150r / min and the stirring time is 10-20min.

[0021] In the present application, the preparation method of component A comprises: adding 30-40 parts of silicon dioxide, 40-55 parts of vinyl silicone oil, 12-20 parts of methyl silicone oil and 0.05-1 parts of platinum complex to a stirring tank by weight, and stirring at a speed of 200r / min for 1 hour to obtain. Preferably, the raw materials for preparing component A include 35 parts of silicon dioxide, 47 parts of vinyl silicone oil, 17.8 parts of methyl silicone oil and 0.2 parts of platinum complex by weight.

[0022] The preparation method of component B comprises: adding 30-40 parts of silicon dioxide, 40-55 parts of vinyl silicone oil, 8-20 parts of methyl silicone oil and 3-10 parts of hydrogen-containing silicone oil to a stirring tank, and continuously stirring at a speed of 200r / min for 1 hour to obtain the obtained component B. Preferably, the raw materials for preparing component B include 35 parts of silicon dioxide, 47 parts of vinyl silicone oil, 10.2 parts of methyl silicone oil and 7.8 parts of hydrogen-containing silicone oil in parts by weight.

[0023] S02: The silicone gel mixture is evenly coated on the protective layer after degassing, left to stand naturally, and covered with a release layer to obtain a silicone gel scar patch.

[0024] The silicone gel mixture is placed in a vacuum drying oven and degassed for 3-20 minutes at room temperature and a vacuum degree of 0.01-0.1MPa to remove bubbles in the silicone gel mixture. After the degassed treatment, the silicone gel mixture is evenly coated on the protective layer with a coating thickness of 1.5mm, and naturally cured for 1-4 hours. After covering the release layer, the silicone gel scar patch is obtained. The silicone gel scar patch is cut according to actual needs and packaged as a finished product after passing the inspection.

[0025] Preferably, the vacuum degree of degassing treatment is 0.05-0.1 MPa, the degassing time is 3-18 min, and the static curing time is 1.5-3 h. More preferably, the vacuum degree of degassing treatment is 0.07-0.1 MPa, and the degassing time is 5-15 min.

[0026] The present invention has the following beneficial effects: (1) Excellent antibacterial properties: The addition of tea tree essential oil, chamomile essential oil, and frankincense essential oil makes the silicone gel scar patch have good antibacterial properties, which can effectively inhibit the growth of bacteria in the scar area, reduce the risk of infection, and promote the clean healing of scars.

[0027] (2) Good anti-inflammatory and soothing effects: The addition of tea tree essential oil, chamomile essential oil, and frankincense essential oil makes the silicone gel scar patch also have anti-inflammatory and soothing effects, which can relieve itching, pain and other discomfort symptoms in the scar area and improve the patient's comfort.

[0028] (3) Good breathability: The use of a polyurethane film protective layer makes the silicone gel scar patch have good breathability, which is beneficial to the skin's breathing and moisture evaporation, and avoids skin discomfort caused by long-term sealing.

[0029] (4) Strong adhesion: The silicone gel layer uses two-component addition-type room temperature vulcanized silicone rubber, which gives the scar patch excellent adhesion. It can be firmly attached to the scar area and is not easy to fall off, ensuring the continuity and stability of the treatment effect.

[0030] (5) Excellent elasticity: The silicone gel layer has good elasticity and can stretch and deform with the movement of the skin. It will not cause pressure or discomfort to the skin and is suitable for scars in various parts of the body.

[0031] (6) The silicone gel scar patch has excellent air permeability and comfort, can effectively promote scar repair, improve scar appearance, and relieve scar itching, pain and other symptoms. It is suitable for various types of scars such as surgical scars, burn scars, and traumatic scars.

[0032] (7) The silicone gel scar patch is soft and smooth, and its skin color design makes it well concealed. Each piece can be used repeatedly for 14-28 days, which improves the economy and convenience of the product.

[0033] (8) The preparation process of the silicone gel scar patch is simple, the cost is controllable, and it has good market application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] Figure 1 HE staining of scar skin in the control group; Figure 2 This is the Masson staining image of scar skin in the control group; Figure 3 HE staining of scar skin in the experimental group; Figure 4 This is the Masson staining image of scar skin in the experimental group. DETAILED DESCRIPTION

[0035] The technical solution of the present invention is further explained and illustrated by means of specific embodiments below.

[0036] Example 1 The embodiment of the present application provides a silicone gel scar patch, including a release layer, a silicone gel layer and a protective layer. The raw materials for preparing the silicone gel layer include 38 parts of component A, 59 parts of component B, 1 part of tea tree essential oil, 1 part of chamomile essential oil and 1 part of frankincense essential oil in parts by weight. Among them, the raw materials for preparing component A include 35 parts of silicon dioxide, 47 parts of vinyl silicone oil, 17.8 parts of methyl silicone oil and 0.2 parts of platinum complex in parts by weight, and the raw materials for preparing component B include 35 parts of silicon dioxide, 47 parts of vinyl silicone oil, 10.2 parts of methyl silicone oil and 7.8 parts of hydrogen-containing silicone oil in parts by weight.

[0037] The preparation method of the silicone gel scar patch provided in the embodiment of the present application includes: S101: According to the above ratio, tea tree essential oil, chamomile essential oil and frankincense essential oil are placed in a stirring bucket and stirred evenly. Then, component A and component B are added in sequence, and an electric stirring rod is used to stir at a stirring speed of 140 r / min for 18 minutes to form a silicone gel mixture.

[0038] S102: Put the silicone gel mixture into a vacuum drying oven and degas for 8 minutes at room temperature and a vacuum degree of 0.1 MPa. Then, evenly apply the silicone gel mixture on the protective layer, let it stand naturally for 2 hours to cure, and then cover it with a release layer to obtain a silicone gel scar patch.

[0039] Example 2 The embodiment of the present application provides a silicone gel scar patch, including a release layer, a silicone gel layer and a protective layer. The raw materials for preparing the silicone gel layer include 45 parts of component A, 52 parts of component B, 1 part of tea tree essential oil, 1.5 parts of chamomile essential oil and 0.5 parts of frankincense essential oil in parts by weight. Among them, the raw materials for preparing component A include 30 parts of silicon dioxide, 55 parts of vinyl silicone oil, 12 parts of methyl silicone oil and 1 part of platinum complex in parts by weight, and the raw materials for preparing component B include 30 parts of silicon dioxide, 55 parts of vinyl silicone oil, 8 parts of methyl silicone oil and 10 parts of hydrogen-containing silicone oil in parts by weight.

[0040] The preparation method of the silicone gel scar patch provided in the embodiment of the present application is the same as that in Example 1, except that the stirring speed is 150 r / min, the stirring time is 20 min, the vacuum degree is 0.08 MPa, the degassing time is 10 min, and the static curing time is 1.5 h.

[0041] Example 3 The embodiment of the present application provides a silicone gel scar patch, including a release layer, a silicone gel layer and a protective layer. The raw materials for preparing the silicone gel layer include 48 parts of component A, 49 parts of component B, 1.5 parts of tea tree essential oil, 1 part of chamomile essential oil and 0.5 parts of frankincense essential oil in parts by weight. Among them, the raw materials for preparing component A include 40 parts of silicon dioxide, 40 parts of vinyl silicone oil, 20 parts of methyl silicone oil and 0.05 parts of platinum complex in parts by weight, and the raw materials for preparing component B include 40 parts of silicon dioxide, 40 parts of vinyl silicone oil, 20 parts of methyl silicone oil and 3 parts of hydrogen-containing silicone oil in parts by weight.

[0042] The preparation method of the silicone gel scar patch provided in the embodiment of the present application is the same as that in Example 1, except that the stirring speed is 120 r / min, the stirring time is 20 min, the vacuum degree is 0.08 MPa, the degassing time is 12 min, and the static curing time is 2 h.

[0043] Example 4 The embodiment of the present application provides a silicone gel scar patch, including a release layer, a silicone gel layer and a protective layer. The raw materials for preparing the silicone gel layer include 40 parts of component A, 56 parts of component B, 2 parts of tea tree essential oil, 1 part of chamomile essential oil and 1 part of frankincense essential oil in parts by weight. Among them, the raw materials for preparing component A include 35 parts of silicon dioxide, 48 parts of vinyl silicone oil, 18 parts of methyl silicone oil and 0.08 parts of platinum complex in parts by weight, and the raw materials for preparing component B include 36 parts of silicon dioxide, 42 parts of vinyl silicone oil, 12 parts of methyl silicone oil and 8 parts of hydrogen-containing silicone oil in parts by weight.

[0044] The preparation method of the silicone gel scar patch provided in the embodiment of the present application is the same as that in Example 1, except that the stirring speed is 120 r / min, the stirring time is 20 min, the vacuum degree is 0.1 MPa, the degassing time is 10 min, and the static curing time is 2 h.

[0045] Example 5 The embodiment of the present application provides a silicone gel scar patch, including a release layer, a silicone gel layer and a protective layer. The raw materials for preparing the silicone gel layer include 42 parts of component A, 54 parts of component B, 1.5 parts of tea tree essential oil, 1.5 parts of chamomile essential oil and 1 part of frankincense essential oil in parts by weight. Among them, the raw materials for preparing component A include 36 parts of silicon dioxide, 42 parts of vinyl silicone oil, 16 parts of methyl silicone oil and 0.07 parts of platinum complex in parts by weight, and the raw materials for preparing component B include 38 parts of silicon dioxide, 50 parts of vinyl silicone oil, 12 parts of methyl silicone oil and 8 parts of hydrogen-containing silicone oil in parts by weight.

[0046] The preparation method of the silicone gel scar patch provided in the embodiment of the present application is the same as that in Example 1, except that the stirring speed is 150 r / min, the stirring time is 10 min, the vacuum degree is 0.1 MPa, the degassing time is 12 min, and the static curing time is 1.5 h.

[0047] Example 6 The embodiment of the present application provides a silicone gel scar patch, including a release layer, a silicone gel layer and a protective layer. The raw materials for preparing the silicone gel layer include 36 parts of component A, 61 parts of component B, 1 part of tea tree essential oil, 1 part of chamomile essential oil and 1 part of frankincense essential oil in parts by weight. Among them, the raw materials for preparing component A include 37 parts of silicon dioxide, 52 parts of vinyl silicone oil, 19 parts of methyl silicone oil and 0.08 parts of platinum complex in parts by weight, and the raw materials for preparing component B include 32 parts of silicon dioxide, 48 parts of vinyl silicone oil, 13 parts of methyl silicone oil and 8 parts of hydrogen-containing silicone oil in parts by weight.

[0048] The preparation method of the silicone gel scar patch provided in the embodiment of the present application is the same as that in Example 1, except that the stirring speed is 130 r / min, the stirring time is 12 min, the vacuum degree is 0.08 MPa, the degassing time is 15 min, and the static curing time is 2 h.

[0049] Example 7 The embodiment of the present application provides a silicone gel scar patch, including a release layer, a silicone gel layer and a protective layer. The raw materials for preparing the silicone gel layer include 40 parts of component A, 56 parts of component B, 1.5 parts of tea tree essential oil, 1.5 parts of chamomile essential oil and 1 part of frankincense essential oil in parts by weight. Among them, the raw materials for preparing component A include 32 parts of silicon dioxide, 43 parts of vinyl silicone oil, 18 parts of methyl silicone oil and 0.07 parts of platinum complex in parts by weight, and the raw materials for preparing component B include 37 parts of silicon dioxide, 43 parts of vinyl silicone oil, 13 parts of methyl silicone oil and 8 parts of hydrogen-containing silicone oil in parts by weight.

[0050] The preparation method of the silicone gel scar patch provided in the embodiment of the present application is the same as that in Example 1, except that the stirring speed is 120 r / min, the stirring time is 12 min, the vacuum degree is 0.1 MPa, the degassing time is 10 min, and the static curing time is 3 h.

[0051] Example 8 The embodiment of the present application provides a silicone gel scar patch, including a release layer, a silicone gel layer and a protective layer. The raw materials for preparing the silicone gel layer include 33 parts of component A, 62 parts of component B, 2 parts of tea tree essential oil, 2 parts of chamomile essential oil and 1 part of frankincense essential oil in parts by weight. Among them, the raw materials for preparing component A include 36 parts of silicon dioxide, 51 parts of vinyl silicone oil, 13 parts of methyl silicone oil and 0.09 parts of platinum complex in parts by weight, and the raw materials for preparing component B include 36 parts of silicon dioxide, 48 parts of vinyl silicone oil, 12 parts of methyl silicone oil and 8 parts of hydrogen-containing silicone oil in parts by weight.

[0052] The preparation method of the silicone gel scar patch provided in the embodiment of the present application is the same as that in Example 1, except that the stirring speed is 135 r / min, the stirring time is 8 min, the vacuum degree is 0.08 MPa, the degassing time is 10 min, and the static curing time is 2.5 h.

[0053] Example 9 The present application embodiment provides a silicone gel scar patch, including a release layer, a silicone gel layer and a protective layer. The raw materials for preparing the silicone gel layer include 40 parts of component A, 56 parts of component B, 2 parts of tea tree essential oil, 1.5 parts of chamomile essential oil and 1.5 parts of frankincense essential oil in parts by weight. Among them, the raw materials for preparing component A include 34 parts of silicon dioxide, 48 parts of vinyl silicone oil, 18 parts of methyl silicone oil and 0.06 parts of platinum complex in parts by weight, and the raw materials for preparing component B include 37 parts of silicon dioxide, 50 parts of vinyl silicone oil, 16 parts of methyl silicone oil and 5 parts of hydrogen-containing silicone oil in parts by weight.

[0054] The preparation method of the silicone gel scar patch provided in the embodiment of the present application is the same as that in Example 1, except that the stirring speed is 120 r / min, the stirring time is 10 min, the vacuum degree is 0.08 MPa, the degassing time is 10 min, and the static curing time is 2 h.

[0055] In order to test the performance of the silicone gel scar patch prepared in the examples of the present application, the silicone gel scar patch prepared in Examples 1-9 was tested for water vapor permeability, temperature adaptability, peel strength, and stretchability, respectively, and the test results shown in Table 1 were obtained. Among them, the test processes of water vapor permeability, temperature adaptability, peel strength, and stretchability all adopted the common test methods in the industry.

[0056] Table 1: Performance parameters of the silicone gel scar patch prepared in Examples 1-9 As shown in Table 1, the water vapor permeability of the silicone gel scar patch prepared in Examples 1-9 is 35-83 g / (m 2 ·24h), peel strength is 0.25-0.60N, stretchability is 0.68-1.15N / cm, and its properties do not change significantly when the temperature changes. It can be seen that the silicone gel scar patch has good air permeability, adhesion and elasticity, which is conducive to the breathing of the skin and the evaporation of moisture, avoiding skin discomfort caused by long-term sealing; it can be firmly attached to the scar area and is not easy to fall off, ensuring the continuity and stability of the treatment effect; it can also stretch and deform with the movement of the skin, without causing pressure or discomfort to the skin.

[0057] In order to evaluate the effectiveness of the silicone gel scar patch prepared in the examples of the present application in preventing and improving early scars after wound healing, the present application used the silicone gel scar patch prepared in Example 5 to conduct animal experimental tests on deep II degree burn scars of Bama miniature pigs.

[0058] Specifically, a deep II degree burn model was performed on the skin of Bama miniature pigs, and 8 Bama miniature pigs with burn skin scar models were successfully modeled. Each Bama miniature pig was divided into 4 areas from top to bottom, and each area included 2 scar models after wound healing. Two areas were randomly selected, and the silicone gel scar patch prepared in Example 5 was applied to the surface of the scar model in each area, and the application was continuous for 58 days, with one change every day to form an experimental group. No other treatment was performed on the surface of the scar model in the remaining 2 areas to form a control group. Each Bama miniature pig was raised in a single cage and moved freely. The skin changes at the scar were observed on the 14th, 28th, 42nd and 58th days after the treatment of the Bama miniature pigs, and the scar repair effect was scored and photographed with reference to the Vancouver Scar Scale (VSS), and the scar healing efficiency of each group was evaluated to obtain Table 2. In addition, after 58 days of treatment, the scar skin at the treatment site of the control group and the experimental group was taken for HE staining and Masson staining, and the attached Figure 1-4 , in order to observe the pathological changes of skin tissue in the scar.

[0059] Table 2: Total effective rate of scar repair in different groups of scar samples from Bama miniature pigs As shown in Table 2, compared with the control group, the experimental group had higher scar repair efficiency after 14, 28, 42 and 58 days of treatment, and there was a significant difference in scar repair efficiency between the experimental group and the control group after 42 days of treatment. This shows that the silicone gel scar patch prepared in Example 5 of the present application can effectively repair burn-induced skin scars.

[0060] Compare with Figure 1 , 3 It can be seen that the epidermis of the control group showed a scab state, while the dermis of the epidermis of the experimental group showed capillary hyperplasia and a small amount of inflammatory cell infiltration. Figure 2 , 4 It can be seen that the fibers in the epidermis of the control group proliferated and were arranged in disorder, and no normal arrangement of collagen fibers was found; the arrangement of collagen fibers in the epidermis of the experimental group was normal. This shows that the silicone gel scar patch prepared in Example 5 of the present application can effectively reconstruct the collagen fibers of burn-induced skin scars, which is beneficial to scar repair.

[0061] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A silicone gel scar patch, characterized in that: The invention comprises a silicone gel layer composed of component A, component B, tea tree essential oil, chamomile essential oil and frankincense essential oil, wherein the raw materials for preparing component A include silicon dioxide, vinyl silicone oil, methyl silicone oil and platinum complex, and the raw materials for preparing component B include silicon dioxide, vinyl silicone oil, methyl silicone oil and hydrogen-containing silicone oil.

2. The silicone gel scar patch according to claim 1, characterized in that: The platinum complex is 1,3-divinyl-1,1,3,3-tetramethyldisiloxane platinum complex.

3. The silicone gel scar patch according to claim 1, characterized in that: The hydrogen-containing silicone oil includes one or more of polydimethylmethylhydrogensiloxane, low hydrogen content side hydrogen-containing silicone oil, and high hydrogen content side hydrogen-containing silicone oil.

4. The silicone gel scar patch according to claim 1, characterized in that: The vinyl silicone oil includes one or more of terminal vinyl silicone oil, high vinyl silicone oil, and low volatility vinyl silicone oil; the methyl silicone oil includes one or more of linear methyl silicone oil, branched methyl silicone oil, and cyclic methyl silicone oil.

5. The silicone gel scar patch according to claim 1, characterized in that: The raw materials for preparing the silicone gel layer include 30-60 parts of component A, 40-70 parts of component B, 1-5 parts of tea tree essential oil, 0.5-5 parts of chamomile essential oil and 0.5-3 parts of frankincense essential oil in parts by weight.

6. The silicone gel scar patch according to claim 1, characterized in that: The raw materials for preparing the component A include 30-40 parts of silicon dioxide, 40-55 parts of vinyl silicone oil, 12-20 parts of methyl silicone oil and 0.05-1 part of platinum complex in parts by weight.

7. The silicone gel scar patch according to claim 1, characterized in that: The raw materials for preparing the component B include 30-40 parts of silicon dioxide, 40-55 parts of vinyl silicone oil, 8-20 parts of methyl silicone oil and 3-10 parts of hydrogen-containing silicone oil in parts by weight.

8. The silicone gel scar patch according to claim 1, characterized in that: The silicone gel scar patch also includes a protective layer and a release layer located on both sides of the silicone gel layer.

9. A method for preparing a silicone gel scar patch, characterized in that: include: After tea tree essential oil, chamomile essential oil and frankincense essential oil are mixed evenly, component A and component B are added and mixed evenly to form a silicone gel mixture; The silicone gel mixture is evenly coated on the protective layer after degassing, left to stand naturally, and covered with a release layer to obtain a silicone gel scar patch.

10. The method for preparing the silicone gel scar patch according to claim 9, characterized in that: The stirring speed is 100-200r / min, and the stirring time is 10-40min; the vacuum degree of degassing is 0.01-0.1MPa, the degassing time is 3-20min, and the degassing temperature is room temperature.

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