Solid dispersion and preparation method thereof, premixed feed and feed

Abstract

The invention discloses a solid dispersion and a preparation method thereof, a premixed feed and a feed. The preparation method of the solid dispersion comprises the following steps: providing raw materials which comprise 50-85 parts by weight of a carrier and 1-35 parts by weight of fat-soluble vitamins; the preparation method comprises the following steps: stirring the raw materials at the temperature of 50-70 DEG C for 10-90 minutes to prepare a mixture; freezing and drying the mixture; the carrier comprises polyethylene glycol with the molecular weight of 400-8000. The solid dispersion containing the fat-soluble vitamins, which is good in water solubility and good in stability, is obtained by compounding the carrier polyethylene glycol with specific molecular weight and the fat-soluble vitamins, stirring by matching with specific stirring parameters, freezing and drying. The solid dispersion is mixed with other components to obtain a water-soluble premixed feed, and the water-soluble premixed feed can be used for keeping the content and stability of fat-soluble vitamins in the feed.

Description

Technical Field

[0001] The present application relates to the field of feed, and in particular to a solid dispersion and a preparation method thereof, a premixed feed and a feed. Background Art

[0002] Feed is the main source of animal nutrition and can also be converted into meat with higher nutritional value by animals. Vitamins are essential nutrients for maintaining the life activities of animals. They often play an important role in various chemical reactions of the body as components of biocatalysts or enzymes, and participate in maintaining the internal environment of the body. When the body lacks vitamins, the growth, development and reproductive capacity of animals will be affected, and even endanger the health of the body. For example, vitamin E plays an important role in improving the reproductive capacity of pigs. It can not only improve the conception rate and increase the litter size, but also enhance the anti-stress ability of piglets, reduce the death of piglets before weaning, and shorten the interval from weaning to estrus of sows. Increasing the intake of vitamin E in sows in a timely manner can enhance ovarian function, increase luteal cells, increase egg survival time, and improve conception rate, litter rate and young survival rate. In addition, vitamin E can maintain the integrity of cell membranes and organelle structures, promote hormone synthesis, and thus maintain a high reproductive capacity of pigs. Vitamin D is an important nutrient that can regulate the metabolism of calcium (Ca) and phosphorus (P). Sows have a very high demand for minerals from late pregnancy to the end of lactation. Vitamin D receptors are expressed in various reproductive tissues such as the endometrium and embryonic chorion, indicating that vitamin D plays a vital role in animal reproductive performance. Vitamin A plays an important role in maintaining high immunity and resistance in animals. When vitamin A is deficient, it will affect the production of related antibodies in the animal body and affect its health level.

[0003] However, fat-soluble vitamins need to be made into oral oil solution preparations because they are difficult to dissolve in water, and they are easily ineffective due to oxidation. There are also methods of making fat-soluble vitamin drugs into nanoemulsions or liposomes as new drug delivery carriers. Nanoemulsions are generally in the form of liquid preparations, or solid preparations are made by encapsulating them in soft capsules. During the mixing process of liquid preparations, latex particles are easy to precipitate and block the nipples of water dispensers, creating suitable breeding conditions for pathogenic microorganisms; the stability is poor and the color tends to darken when exposed to light, and turbidity is prone to occur; the compatibility of the system is poor, and it is difficult to compound with other beneficial ingredients. The production process of nanoemulsion soft capsules is complicated, the compatibility of the preparation ingredients with the capsule shell is poor, and capsule leakage may occur during long-term storage; there are also disadvantages such as poor stability of liposomes and high cost of excipients. Summary of the invention

[0004] Based on this, it is necessary to provide a solid dispersion containing fat-soluble vitamins with good water solubility and stability, a preparation method thereof, a premix feed and a pig feed.

[0005] The present application provides a method for preparing a solid dispersion, comprising the following steps:

[0006] Providing raw materials, wherein the raw materials include 50 to 85 parts by weight of a carrier and 1 to 35 parts by weight of a fat-soluble vitamin;

[0007] The raw materials are stirred at a temperature of 50° C. to 70° C. for 10 minutes to 90 minutes to prepare a mixture;

[0008] Freezing and drying the mixture;

[0009] Wherein, the carrier comprises polyethylene glycol with a molecular weight of 400-8000.

[0010] In one embodiment, the fat-soluble vitamins include one or more of vitamin A, vitamin D3 and vitamin E.

[0011] In one embodiment, the raw materials further include 5 to 25 parts by weight of auxiliary materials, and the auxiliary materials include one or more of starch, anhydrous glucose, sucrose, sodium lauryl sulfate and povidone K30.

[0012] In one embodiment, the stirring speed is 500r / min~2500r / min.

[0013] In one embodiment, the freezing temperature is -25°C to -5°C, and the freezing time is 2 hours to 28 hours.

[0014] In one embodiment, the drying temperature is 20° C. to 60° C., and the drying time is 2 hours to 24 hours.

[0015] The present application also provides a solid dispersion prepared according to the above preparation method.

[0016] Furthermore, the present application also provides a premixed feed, comprising the solid dispersion as described above.

[0017] In one embodiment, the present invention comprises, by weight percentage, 0.3% to 30% of the solid dispersion as described above, 0.1% to 10% of vitamin C, 0.1% to 10% of vitamin B1, 0.1% to 10% of vitamin B6, 0.1% to 10% of D-biotin, 0.1% to 10% of L-carnitine, 0.1% to 10% of D-calcium pantothenate, 0.1% to 10% of B-carotene, 0.1% to 10% of niacin, and 50% to 90% of glucose.

[0018] Furthermore, the present application also provides a feed, comprising the solid dispersion as described above or the premixed feed as described above.

[0019] The solid dispersion provided by the present application is compounded with polyethylene glycol of a specific molecular weight of a carrier and fat-soluble vitamins, and stirred with specific stirring parameters, and then frozen and dried to finally obtain a solid dispersion containing fat-soluble vitamins with good water solubility and good stability. The above solid dispersion is then mixed with other ingredients to obtain a water-soluble premixed feed, which can be used in feed to maintain the content of fat-soluble vitamins in the feed and the stability of fat-soluble vitamins. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the specific implementation methods of the present application or the technical solutions in the prior art, the drawings required for use in the specific implementation methods or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some implementation methods of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0021] Figure 1 This is an appearance diagram showing the water solubility of the premixed feed provided in this application.

[0022] Figure 2 Appearance of the premixed feed provided for this application. DETAILED DESCRIPTION

[0023] In order to facilitate the understanding of the present application, the present application will be described more fully below with reference to the relevant drawings. The preferred embodiments of the present application are given in the drawings. However, the present application can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the understanding of the disclosure of the present application more thorough and comprehensive.

[0024] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as those commonly understood by those skilled in the art to which this application belongs. The terms used herein in the specification of this application are only for the purpose of describing specific embodiments and are not intended to limit this application.

[0025] The term "and / or" used herein includes any one of two or more related listed items, and also includes any and all combinations of the related listed items, wherein the any and all combinations include any combination of two related listed items, any more related listed items, or all related listed items. For example, "A and / or B" includes three parallel solutions: A, B, and "a combination of A and B".

[0026] In this article, unless otherwise specified, "one or more" means any one of the listed items or any combination of the listed items. Similarly, "one or more" and other expressions that mean "one or more" are also understood in the same way unless otherwise specified.

[0027] In this document, "further", "further", "particularly", "for example", "such as", "example", "for example", etc. are used for descriptive purposes, indicating that the previous and subsequent technical solutions are related in terms of the content covered, but should not be understood as limiting the previous technical solution, nor can they be understood as limiting the scope of protection of this document. In this document, unless otherwise specified, A (such as B) means that B is a non-limiting example of A, and it can be understood that A is not limited to B.

[0028] Herein, "optionally", "optional", and "optional" mean optional, that is, any one of the two parallel schemes of "yes" or "no". If multiple "optional" items appear in a technical solution, unless otherwise specified and there is no contradiction or mutual restriction, each "optional" item is independent of each other. In this application, descriptions such as "optionally contain", "optionally include", etc. mean "contain or not contain". "Optional component X" means that component X exists or does not exist, or means that component X is contained or not contained.

[0029] In this document, the terms "first", "second", "third", "fourth", etc. in "the first aspect", "the second aspect", "the third aspect", "the fourth aspect", etc. are used only for descriptive purposes and cannot be understood as indicating or implying relative importance or quantity, nor can they be understood as implicitly indicating the importance or quantity of the indicated technical features. Moreover, "first", "second", "third", "fourth", etc. only serve the purpose of non-exhaustive enumeration and description, and it should be understood that they do not constitute a closed limitation on quantity.

[0030] In this article, the technical features described in an open manner include closed technical solutions composed of the listed features, and also include open technical solutions containing the listed features.

[0031] Herein, when it comes to a numerical interval (i.e., a numerical range), unless otherwise specified, the distribution of the optional numerical values ​​within the numerical interval is considered to be continuous and includes the two numerical endpoints (i.e., the minimum and maximum values) of the numerical interval, and each numerical value between the two numerical endpoints. Unless otherwise specified, when a numerical interval only refers to integers within the numerical interval, including the two endpoint integers of the numerical range, and each integer between the two endpoints, is equivalent to directly listing each integer. When multiple numerical ranges are provided to describe features or characteristics, these numerical ranges can be combined. In other words, unless otherwise specified, the numerical ranges disclosed herein should be understood to include any and all sub-ranges included therein. The "numerical value" in the numerical interval can be any quantitative value, such as a number, a percentage, a ratio, etc. "Numerical interval" allows broadly including numerical interval types such as percentage intervals, ratio intervals, and ratio intervals.

[0032] Herein, the term "room temperature" or "normal temperature" generally refers to 4°C~35°C, for example, 20°C±5°C. In some embodiments herein, "room temperature" or "normal temperature" refers to 10°C~30°C. In some embodiments herein, "room temperature" or "normal temperature" refers to 20°C~30°C.

[0033] In this article, if there are multiple steps involved in the method flow, unless there is a clear different description in this article, there is no strict order restriction for the execution of these steps, and they can be executed in other orders than described. Moreover, any step can include multiple sub-steps or multiple stages, and these sub-steps or stages are not necessarily executed at the same time, but can be executed at different times, and their execution order is not necessarily sequential, but can be executed in turn, alternating or simultaneously with other steps or parts of sub-steps or stages of other steps.

[0034] The present application provides a method for preparing a solid dispersion, comprising the following steps:

[0035] Providing raw materials, the raw materials comprising 50 to 85 parts by weight of a carrier and 1 to 35 parts by weight of a fat-soluble vitamin;

[0036] The raw materials are stirred at a temperature of 50°C to 70°C for 10 minutes to 90 minutes to prepare a mixture;

[0037] Freezing and drying the mixture;

[0038] Wherein, the carrier includes polyethylene glycol with a molecular weight of 400-8000.

[0039] In a specific example, the fat-soluble vitamins include one or more of vitamin A, vitamin D3, and vitamin E.

[0040] Further, the stirring temperature can be but is not limited to 50°C, 55°C, 60°C, 65°C or 70°C, and the stirring time can be but is not limited to 10 minutes, 15 minutes, 20 minutes, 25 minutes, 30 minutes, 35 minutes, 40 minutes, 45 minutes, 50 minutes, 55 minutes, 60 minutes, 65 minutes, 70 minutes, 75 minutes, 80 minutes, 85 minutes or 90 minutes.

[0041] Furthermore, the molecular weight of the polyethylene glycol can be, but is not limited to, 400, 500, 600, 700, 800, 900, 1000, 1500, 2000, 2500, 3000, 3500, 4000, 4500, 5000, 5500, 6000, 6500, 7000, 7500 or 8000.

[0042] Specifically, the content of polyethylene glycol having a molecular weight of greater than or equal to 400 and less than 1000 in the carrier is less than or equal to 10%.

[0043] In a specific example, the raw materials further include 5 to 25 parts by weight of auxiliary materials, and the auxiliary materials include one or more of starch, anhydrous glucose, sucrose, sodium lauryl sulfate and povidone K30.

[0044] Specifically, the carrier of the above raw materials is first heated to 60°C~80°C, then the temperature is lowered to 55°C~70°C, vitamin E is added and stirred, and then auxiliary materials are added.

[0045] In a specific example, the stirring speed is 500 r / min~2500 r / min.

[0046] Further, the stirring speed can be but is not limited to 500r / min, 600r / min, 700r / min, 800r / min, 900r / min, 1000r / min, 1100r / min, 1200r / min, 1300r / min, 1400r / min, 1500r / min, 1600r / min, 1700r / min, 1800r / min, 1900r / min, 2000r / min, 2100r / min, 2200r / min, 2300r / min, 2400r / min or 2500r / min.

[0047] In a specific example, the freezing temperature is -25°C to -5°C, and the freezing time is 2 hours to 28 hours.

[0048] Specifically, the freezing temperature can be but is not limited to -25°C, -20°C, -15°C, -10°C or -5°C, and the freezing time can be but is not limited to 2 hours, 4 hours, 6 hours, 8 hours, 10 hours, 12 hours, 14 hours, 16 hours, 18 hours, 20 hours, 22 hours, 24 hours, 26 hours or 28 hours.

[0049] In a specific example, the drying temperature is 20° C. to 60° C., and the drying time is 2 hours to 24 hours.

[0050] Further, the drying temperature can be but is not limited to 20°C, 22°C, 24°C, 26°C, 28°C, 30°C, 32°C, 34°C, 36°C, 38°C, 40°C, 42°C, 44°C, 46°C, 48°C, 50°C, 52°C, 54°C, 56°C, 58°C or 60°C.

[0051] In a specific example, the step of crushing is further included after drying. Specifically, the crushing is performed until the solid particles can pass through a sieve of 100-400 meshes.

[0052] The present application also provides a solid dispersion prepared according to the above preparation method.

[0053] Furthermore, the present application also provides a premixed feed, comprising the solid dispersion as described above.

[0054] In a specific example, by weight percentage, it includes 0.3% to 30% of the solid dispersion as described above, 0.1% to 10% of vitamin C, 0.1% to 10% of vitamin B1, 0.1% to 10% of vitamin B6, 0.1% to 10% of D-biotin, 0.1% to 10% of L-carnitine, 0.1% to 10% of D-calcium pantothenate, 0.1% to 10% of B-carotene, 0.1% to 10% of niacin and 50% to 90% of glucose.

[0055] It can be understood that the raw materials of the premix feed are stirred for 40 minutes to 120 minutes. Specifically, the stirring time can be but is not limited to 40 minutes, 50 minutes, 60 minutes, 70 minutes, 80 minutes, 90 minutes, 100 minutes, 110 minutes or 120 minutes.

[0056] Furthermore, the present application also provides a feed, comprising the solid dispersion or the premixed feed as described above. It can be understood that the feed is preferably pig feed.

[0057] The solid dispersion provided by the present application is compounded with polyethylene glycol of a specific molecular weight of a carrier and fat-soluble vitamins, and stirred with specific stirring parameters, and then frozen and dried to finally obtain a solid dispersion containing fat-soluble vitamins with good water solubility and good stability. The above solid dispersion is then mixed with other ingredients to obtain a water-soluble premixed feed, which can be used in feed to maintain the content of fat-soluble vitamins in the feed and the stability of fat-soluble vitamins.

[0058] The present application is further described in detail below in conjunction with specific examples. It should be understood that these examples are only used to illustrate the present application and are not intended to limit the scope of the present application. The experimental methods for which specific conditions are not specified in the following examples are preferably referred to the guidance given in the present application, and can also be based on the experimental manuals or conventional conditions in the art, can also be based on the conditions recommended by the manufacturer, or refer to experimental methods known in the art.

[0059] In the following specific embodiments, the measured parameters of raw material components may have slight deviations within the range of weighing accuracy unless otherwise specified. For temperature and time parameters, acceptable deviations caused by instrument test accuracy or operation accuracy are allowed. "Normal temperature" refers to 25°C; "normal pressure" refers to 100KPa or 101KPa.

[0060] Example 1

[0061] The present application provides a solid dispersion, comprising the following steps:

[0062] 1. Take 65 parts by weight of the carrier polyethylene glycol 6000 and put it into a beaker. Put the beaker into a 70°C water bath and wait until the polyethylene glycol 6000 is completely dissolved into liquid.

[0063] 2. Lower the temperature to 57°C, wait until the system temperature is stable, add 26 parts by weight of vitamin E, stir while adding, stir evenly after adding, then continue to add 3 parts by weight of sodium dodecyl sulfate and 5 parts by weight of povidone K30.

[0064] 3. Control the temperature at 57°C, stir for 1 hour, and the speed is 1400r / min.

[0065] 4. Pour into a pre-frozen stainless steel tray and immediately freeze at -20°C for 4 hours.

[0066] 5. Take out and dry at about 40℃ for 5 hours.

[0067] 6. After drying, crush the mixture and pass it through a 100-mesh sieve to obtain a vitamin E solid dispersion.

[0068] Example 2

[0069] The present application provides a solid dispersion, comprising the following steps:

[0070] 1. Take 75 parts by weight of the carrier (polyethylene glycol PEG4000 with a molecular weight of 4000: polyethylene glycol PEG400 with a molecular weight of 400, the mass ratio is 9:1) and put it into a beaker, put the beaker into a 60°C water bath, and wait until the carrier is completely dissolved into liquid.

[0071] 2. Lower the temperature to 55°C, wait until the system temperature is stable, add 10 parts by weight of vitamin E, stir while adding, stir evenly after adding, and then continue to add 10 parts by weight of povidone K30 and 5 parts by weight of starch.

[0072] 3. Control the temperature at 55°C, stir for 0.5 hours, and the speed is 800r / min.

[0073] 4. Pour into a pre-frozen stainless steel tray and immediately freeze at -10°C for 24 hours.

[0074] 5. Take out and dry at about 25℃ for 20 hours.

[0075] 6. After drying, crush the mixture and pass it through a 100-mesh sieve to obtain a vitamin E solid dispersion.

[0076] Example 3

[0077] The present application provides a solid dispersion, comprising the following steps:

[0078] 1. Take 60 parts by weight of the carrier (polyethylene glycol PEG8000 with a molecular weight of 8000: polyethylene glycol PEG1000 with a molecular weight of 1000: polyethylene glycol PEG400 with a molecular weight of 400, the mass ratio is 7:2:1) and put it into a beaker, put the beaker into an 80℃ water bath, and wait until the carrier is completely dissolved into liquid.

[0079] 2. Lower the temperature to 65°C, wait until the system temperature is stable, add 30 parts by weight of vitamin E alcohol solution (dissolve vitamin E in ethanol to make a solution with a mass ratio of vitamin E to ethanol of 10:90), stir while adding, stir evenly after adding, and then continue to add 10 parts by weight of sucrose.

[0080] 3. Control the temperature at 65°C, stir for 15 minutes, and the speed is 2000r / min.

[0081] 4. Pour into a pre-frozen stainless steel tray and immediately freeze at -10°C for 10 hours.

[0082] 5. Take out and dry at about 50℃ for 4 hours.

[0083] 6. After drying, crush the mixture and pass it through a 100-mesh sieve to obtain a vitamin E solid dispersion.

[0084] Example 4

[0085] The present application provides a solid dispersion, comprising the following steps:

[0086] 1. Take 65 parts by weight of the carrier polyethylene glycol 6000 and put it into a beaker. Put the beaker into a 70°C water bath and wait until the polyethylene glycol 6000 is completely dissolved into liquid.

[0087] 2. Lower the temperature to 57°C, wait until the system temperature is stable, add 26 parts by weight of vitamin A, stir while adding, stir evenly after adding, then continue to add 3 parts by weight of sodium dodecyl sulfate and 5 parts by weight of povidone K30.

[0088] 3. Control the temperature at 57°C, stir for 1 hour, and the speed is 1400r / min.

[0089] 4. Pour into a pre-frozen stainless steel tray and immediately freeze at -20°C for 4 hours.

[0090] 5. Take out and dry at about 40℃ for 5 hours.

[0091] 6. After drying, crush the mixture and pass it through a 100-mesh sieve to obtain a vitamin A solid dispersion.

[0092] Example 5

[0093] The present application provides a solid dispersion, comprising the following steps:

[0094] 1. Take 65 parts by weight of the carrier polyethylene glycol 6000 and put it into a beaker. Put the beaker into a 70°C water bath and wait until the polyethylene glycol 6000 is completely dissolved into liquid.

[0095] 2. Lower the temperature to 57°C, wait until the system temperature is stable, add 26 parts by weight of vitamin D3, stir while adding, stir evenly after adding, then continue to add 3 parts by weight of sodium dodecyl sulfate and 5 parts by weight of povidone K30.

[0096] 3. Control the temperature at 57°C, stir for 1 hour, and the speed is 1400r / min.

[0097] 4. Pour into a pre-frozen stainless steel tray and immediately freeze at -20°C for 4 hours.

[0098] 5. Take out and dry at about 40℃ for 5 hours.

[0099] 6. After drying, crush the mixture and pass it through a 100-mesh sieve to obtain a vitamin D3 solid dispersion.

[0100] The solubility and stability of the solid dispersions in the above-mentioned embodiments were tested. The solubility test conditions are as follows: at room temperature, the solid dispersions of each embodiment were placed in water to obtain their solubility; the stability test conditions are as follows: after the solid dispersions were completely dissolved in water at room temperature, they were left to stand for 12 hours to observe whether there was any precipitation or floccules. If there was any precipitation or floccules, it was unstable; if there was no precipitation or floccules, it was stable. The test results are shown in the following table.

[0101] Table 1

[0102]

[0103] A premix feed is prepared using a solid dispersion, and the solid dispersion of Example 1 is taken, and the composition of the premix feed is 5% vitamin A, 5% vitamin D3, 6% vitamin E, 8% vitamin C, 4% vitamin B1, 3% vitamin B6, 7% D-biotin, 8% L-carnitine, 6% D-calcium pantothenate, 4% β-carotene, 5% niacin and 45% glucose, so that the range values ​​of each component in the following table are met.

[0104]

[0105] like Figure 1 The following is the appearance of the above premixed feed. It can be seen that the color is uniform and there is no odor, mold, deterioration or caking. The crushed particle size of the premixed feed: all should pass through the standard sieve with a mesh side length of 1.19mm; the particles on the sieve should not exceed 10% if they pass through the standard sieve with a mesh side length of 0.59mm. Figure 2 The figure shows the water solubility test of the above premix feed. The solubility reaches 3 g / L at room temperature. It is completely dissolved and the liquid is a uniform clear yellow aqueous solution. No precipitation or floccules appear after standing for 12 hours.

[0106] The technical features of the above-described embodiments may be arbitrarily combined. To make the description concise, not all possible combinations of the technical features in the above-described embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0107] The above-described embodiments only express several implementation methods of the present application, which is convenient for understanding the technical solution of the present application in detail, but it cannot be understood as limiting the scope of protection of the invention patent. It should be pointed out that for ordinary technicians in this field, without departing from the concept of the present application, several modifications and improvements can be made, which all belong to the protection scope of the present application. It should be understood that the technical solutions obtained by those skilled in the art through logical analysis, reasoning or limited experiments on the basis of the technical solutions provided in the present application are all within the protection scope of the claims attached to the present application. Therefore, the protection scope of the patent of this application shall be based on the contents of the attached claims, and the description and drawings can be used to explain the contents of the claims.

Claims

1. A method for preparing a solid dispersion, characterized in that: The following steps are involved: Providing raw materials, wherein the raw materials include 50 to 85 parts by weight of a carrier and 1 to 35 parts by weight of a fat-soluble vitamin; The raw materials are stirred at a temperature of 50° C. to 70° C. for 10 minutes to 90 minutes to prepare a mixture; Freezing and drying the mixture; Wherein, the carrier comprises polyethylene glycol with a molecular weight of 400-8000.

2. The preparation method according to claim 1, characterized in that The fat-soluble vitamins include one or more of vitamin A, vitamin D3 and vitamin E.

3. The preparation method according to claim 1, characterized in that: The raw materials also include 5 to 25 parts by weight of auxiliary materials, and the auxiliary materials include one or more of starch, anhydrous glucose, sucrose, sodium lauryl sulfate and povidone K30.

4. The preparation method according to claim 1, characterized in that: The stirring speed is 500r / min~2500r / min.

5. The preparation method according to any one of claims 1 to 4, characterized in that The freezing temperature is -25°C to -5°C, and the freezing time is 2 hours to 28 hours.

6. The preparation method according to any one of claims 1 to 4, characterized in that: The drying temperature is 20° C. to 60° C., and the drying time is 2 hours to 24 hours.

7. A solid dispersion, characterized in that Prepared according to the preparation method according to any one of claims 1 to 6.

8. A premixed feed, characterized in that: Comprising the solid dispersion as claimed in claim 7.

9. The premixed feed according to claim 8, characterized in that In terms of weight percentage, the solid dispersion according to claim 7 is included in an amount of 0.3% to 30%, vitamin C is included in an amount of 0.1% to 10%, vitamin B1 is included in an amount of 0.1% to 10%, vitamin B6 is included in an amount of 0.1% to 10%, D-biotin is included in an amount of 0.1% to 10%, L-carnitine is included in an amount of 0.1% to 10%, calcium D-pantothenate is included in an amount of 0.1% to 10%, B-carotene is included in an amount of 0.1% to 10%, niacin is included in an amount of 50% to 90%, and glucose is included in an amount of 50% to 90%.

10. A feed, characterized in that: Comprising the solid dispersion according to claim 7 or the premix feed according to claim 8 or 9.

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