Feed additive for relieving ruminant rumen acidosis and production process thereof

Abstract

The invention discloses a feed additive for relieving ruminant rumen acidosis and a production process thereof, and the production process comprises the following steps: mixing starch-based Schiff base and deionized water in a reaction kettle to prepare a starch suspension, adding an oil suspension into the reaction kettle, heating until stirring, cooling, drying in vacuum, and crushing to obtain the feed additive for relieving ruminant rumen acidosis. And sieving to obtain the feed additive for relieving ruminant rumen acidosis. The prepared feed additive for relieving ruminant rumen acidosis can be stored under a dry condition, granulation and feed mixing are convenient, the feed additive contains starch and vegetable oil and is convenient for livestock to absorb, and rumen acid is rapidly neutralized by utilizing selenium-loaded magnesium oxide and sulfathiazole in the feed additive, so that the ruminant rumen acidosis is relieved, and the ruminant rumen acidosis is relieved. The absorption of the livestock on selenium element is improved through selenium salt in the selenium-loaded magnesium oxide, so that the immunity of the livestock is improved.

Description

Technical Field

[0001] The invention belongs to the technical field of additional food elements for animal feed, and in particular relates to a feed additive for alleviating rumen acidosis in ruminants and a production process thereof. Background Art

[0002] Subacute rumen acidosis is a metabolic disorder that is common in ruminants, especially high-producing dairy cows. This is mainly due to the metabolic problems caused by the widespread use of high-grain diets by farmers to increase milk production. This disease not only reduces milk production and fat content in dairy cows, but also causes a variety of health problems such as diarrhea, mastitis and lamellar lesions, causing considerable economic losses to the dairy farming industry and has a significant impact on herd productivity and welfare in the modern dairy industry.

[0003] Patent CN115636604A discloses a method for preparing magnesium oxide particles from low-grade magnesite, a feed additive containing the particles, and a preparation method and application thereof. Nano-grade magnesium oxide powder is prepared from low-grade magnesite, and the feed additive is prepared by compounding it with trace elements, vitamin D, a Chinese medicine composition, etc., so as to effectively supplement the nutritional minerals such as magnesium and trace elements lacking in ruminants. At the same time, it has a sustained-release effect on rumen pH regulation. However, the scheme has a slow effect on regulating pH value and has a low effect on alleviating subacute rumen acidosis.

[0004] Patent CN116762899A discloses a feed additive for treating / preventing animal rumen acidosis and a preparation method thereof, wherein sodium bicarbonate and magnesium oxide are used to directly neutralize rumen organic acid, increase rumen pH, and stabilize the internal environment; then, thiamine, nicotinamide, and biotin are used to balance lactic acid-utilizing bacteria and lactic acid-producing bacteria in the rumen, and Bacillus subtilis and Saccharomyces cerevisiae are added to improve the digestive capacity of animals; however, in this scheme, the additive is prepared by directly mixing bacteria, enzymes, magnesium oxide, and sodium bicarbonate, and has poor uniformity and low dispersibility. The alkaline environment in the additive is also not conducive to the long-term storage of the flora, and it is not easy to form a suitable pH environment in the rumen, and the effectiveness of the beneficial flora and enzymes in exerting their activities is low.

[0005] Therefore, there is a need for a feed additive for alleviating rumen acidosis in ruminants, which can effectively and quickly alleviate the rumen acidosis phenomenon when the livestock have already developed rumen acidosis and is beneficial to improving the immunity of the livestock. Summary of the invention

[0006] The purpose of the present invention is to solve the problem of how to quickly and effectively alleviate the rumen acidosis phenomenon and improve the immunity of livestock, and to provide a feed additive for alleviating rumen acidosis in ruminants and a production process thereof.

[0007] The present invention attaches selenate to a porous nano magnesium oxide carrier made of Mg-MOF and disperses it in vegetable oil. The hydrophobic effect of vegetable oil and starch is combined to mix flour combined with sulfathiazole with the vegetable oil. The magnesium oxide and sulfathiazole act synergistically to quickly alleviate rumen acidosis.

[0008] The purpose of the present invention can be achieved through the following technical solutions:

[0009] The production process of a feed additive for alleviating rumen acidosis in ruminants comprises the following steps:

[0010] The starch-based Schiff base is mixed with deionized water in a reactor to prepare a starch suspension, the oil suspension is added to the reactor, the temperature is raised to 70-80° C. and stirred for 20-30 minutes, the mixture is vacuum dried after cooling, crushed, and sieved to obtain a feed additive for alleviating rumen acidosis in ruminants.

[0011] Furthermore, the oil suspension is prepared by ultrasonically dispersing selenium-loaded magnesium oxide in wheat germ oil.

[0012] Furthermore, the usage ratio of selenium-loaded magnesium oxide and wheat germ oil is 0.3-0.6 g:15-25 g.

[0013] Further, the loaded selenium magnesium oxide is prepared by the following steps:

[0014] The cubic porous magnesium oxide was placed in a 5 mg / L tin salt solution, the pH value was adjusted to 10-11 with concentrated hydrochloric acid, the mixture was stirred and adsorbed for 3-4 hours, and vacuum dried after filtration to obtain selenium-loaded magnesium oxide.

[0015] Furthermore, the tin salt solution is prepared by dissolving sodium selenite and sodium selenate in deionized water in equal proportions.

[0016] Furthermore, the usage ratio of starch-based Schiff base, deionized water and oil suspension is 20-40 g: 200-300 mL: 15-25 g.

[0017] Furthermore, the usage ratio of the cubic porous magnesium oxide and the selenium salt solution is 10-15 g: 5-8 L.

[0018] Further, the cubic porous magnesium oxide is prepared by the following steps:

[0019] In a reaction kettle, 2-methylimidazole and magnesium chloride hexahydrate are dissolved in N, N-dimethylformamide, stirred and mixed, heated to 130-150° C. and stirred for reaction for 20-24 hours, and the precipitate is collected by centrifugation. The precipitate is washed with methanol and N, N-dimethylformamide, and then vacuum dried at 60-70° C. for 12-14 hours, and then ground with agate for 1-2 minutes, and then placed in a muffle furnace and heated to 550-600° C. and calcined for 12-14 hours to obtain cubic porous magnesium oxide.

[0020] Furthermore, the usage ratio of 2-methylimidazole, magnesium chloride hexahydrate and N,N-dimethylformamide is 8-10 g:20-25 g:1.2-1.4 L.

[0021] Further, the starch-based Schiff base is prepared by the following steps:

[0022] The dialdehyde starch and ethanol are mixed in a reaction kettle, sulfathiazole is added, and the mixture is refluxed and heated to 50-60° C. for reaction for 40-48 hours. The mixture is filtered, washed with deionized water and ethanol, and vacuum dried to obtain a starch-based Schiff base.

[0023] Furthermore, the usage ratio of dialdehyde starch, ethanol and sulfathiazole is 30-50 g: 200-300 mL: 10-15 g.

[0024] Further, dialdehyde starch is prepared by the following steps:

[0025] In a reaction kettle, corn starch is added into deionized water, potassium periodate is added dropwise, the temperature is raised to 50-60° C., stirred for reaction for 2-3 hours, allowed to stand for 40-48 hours, filtered, the precipitate is washed with deionized water, and vacuum dried to obtain dialdehyde starch.

[0026] Furthermore, the usage ratio of corn starch, deionized water and potassium periodate is 50-60 g: 5-6 L: 100-150 g.

[0027] Beneficial effects of the present invention:

[0028] (1) The feed additive for alleviating rumen acidosis in ruminants prepared by the present invention can be stored under dry conditions, which is convenient for granulation and feed mixing. The feed additive contains starch and vegetable oil, which is convenient for livestock to absorb. The loaded selenium magnesium oxide and sulfathiazole in the feed additive are used to quickly neutralize rumen acid and alleviate rumen acidosis. The selenium salt in the loaded selenium magnesium oxide is used to improve the absorption of selenium by livestock, thereby improving the immunity of livestock.

[0029] (2) The production process of the present invention oxidizes the porous Mg-MOF to generate cubic porous magnesium oxide, so that the generated cubic porous magnesium oxide has a porous structure and good dispersibility in vegetable oil. The porous structure of MgO and the adsorption effect of selenate are used to load selenate on the cubic porous magnesium oxide, thereby increasing the content of selenium in livestock and improving the immunity of livestock. Sulfathiazole, which has a direct effect on alleviating the symptoms of rumen acidosis, is grafted on the starch chain by oxidizing starch and then grafting it with sulfathiazole. The vegetable oil and starch are then mixed by the hydrophobic effect. The loaded magnesium oxide loaded with selenate is mixed with the starch-based Schiff base by using the vegetable oil, and the mixing degree is uniform and the bonding strength is good. DETAILED DESCRIPTION

[0030] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0031] Example 1: A production process of a feed additive for alleviating rumen acidosis in ruminants, comprising the following steps:

[0032] S1. Dissolve 8 g of 2-methylimidazole and 20 g of magnesium chloride hexahydrate in 1.2 L of N, N-dimethylformamide in a reaction kettle, heat to 130° C. and stir to react for 20 h. Collect the precipitate by centrifugation, wash the precipitate with methanol and N, N-dimethylformamide, and then vacuum dry it at 60° C. for 12 h. Then grind it with agate for 1 min, place it in a muffle furnace, heat it to 550° C. and calcine it for 12 h to obtain cubic porous magnesium oxide.

[0033] S2. Dissolve sodium selenite and sodium selenate in deionized water in equal proportions to prepare a tin salt solution with a selenium concentration of 5 mg / L, place 10 g of cubic porous magnesium oxide in 5 L of the tin salt solution, adjust the pH value to 10 with concentrated hydrochloric acid, stir and adsorb for 3 h, filter and vacuum dry to obtain selenium-loaded magnesium oxide.

[0034] S3. Add 50 g corn starch to 5 L deionized water in a reactor, add 100 g potassium periodate dropwise, raise the temperature to 50° C. and stir to react for 2 h. After standing for 40 h, filter, wash the precipitate with deionized water, and vacuum dry to obtain dialdehyde starch.

[0035] S4. Mix 30 g of dialdehyde starch with 200 mL of ethanol in a reactor, add 10 g of sulfathiazole, reflux and heat to 50° C. to react for 40 h, filter, wash with deionized water and ethanol, and vacuum dry to obtain a starch-based Schiff base.

[0036] S5. In a reactor, 20 g of starch-based Schiff base was mixed with 200 mL of deionized water to prepare a starch suspension, 0.3 g of selenium-loaded magnesium oxide was ultrasonically dispersed in 15 g of wheat germ oil to obtain an oil suspension, 15 g of the oil suspension was added to the reactor, the temperature was raised to 70° C. and stirred for 20 min, the mixture was cooled and vacuum dried at 80° C. for 5 h, the mixture was crushed, and the mixture was sieved to obtain a feed additive for alleviating rumen acidosis in ruminants.

[0037] Example 2: A production process of a feed additive for alleviating rumen acidosis in ruminants, comprising the following steps:

[0038] S1. Dissolve 9 g of 2-methylimidazole and 22.5 g of magnesium chloride hexahydrate in 1.3 L of N, N-dimethylformamide in a reaction kettle, heat to 140° C. and stir to react for 22 h. Collect the precipitate by centrifugation, wash the precipitate with methanol and N, N-dimethylformamide, and then vacuum dry it at 65° C. for 13 h. Then grind it with agate for 1.5 min, place it in a muffle furnace, heat it to 575° C. and calcine it for 13 h to obtain cubic porous magnesium oxide.

[0039] S2. Dissolve sodium selenite and sodium selenate in deionized water in equal proportions to prepare a tin salt solution with a selenium concentration of 5 mg / L, place 12.5 g of cubic porous magnesium oxide in 6.5 L of the tin salt solution, adjust the pH value to 10.5 with concentrated hydrochloric acid, stir and adsorb for 3.5 h, filter and vacuum dry to obtain selenium-loaded magnesium oxide.

[0040] S3. In a reactor, add 55 g corn starch into 5.5 L deionized water, add 125 g potassium periodate dropwise, raise the temperature to 55° C. and stir to react for 2.5 h. After standing for 44 h, filter, wash the precipitate with deionized water, and vacuum dry to obtain dialdehyde starch.

[0041] S4. In a reactor, 40 g of dialdehyde starch was mixed with 250 mL of ethanol, 12.5 g of sulfathiazole was added, and the mixture was refluxed to 55° C. and reacted for 44 h. After filtering, the mixture was washed with deionized water and ethanol, and vacuum dried to obtain a starch-based Schiff base.

[0042] S5. In a reactor, 30 g of starch-based Schiff base was mixed with 250 mL of deionized water to prepare a starch suspension, 0.45 g of selenium-loaded magnesium oxide was ultrasonically dispersed in 20 g of wheat germ oil to obtain an oil suspension, 20 g of the oil suspension was added to the reactor, the temperature was raised to 75° C. and stirred for 25 min, the mixture was cooled and vacuum dried at 85° C. for 5.5 h, the mixture was crushed, and the mixture was sieved to obtain a feed additive for alleviating rumen acidosis in ruminants.

[0043] Example 3: A production process of a feed additive for alleviating rumen acidosis in ruminants, comprising the following steps:

[0044] S1. Dissolve 10 g of 2-methylimidazole and 25 g of magnesium chloride hexahydrate in 1.4 L of N, N-dimethylformamide in a reaction kettle, heat to 150° C. and stir to react for 24 h. Collect the precipitate by centrifugation, wash the precipitate with methanol and N, N-dimethylformamide, and then vacuum dry it at 70° C. for 14 h. Then grind it with agate for 2 min, place it in a muffle furnace, heat it to 600° C. and calcine it for 14 h to obtain cubic porous magnesium oxide.

[0045] Cubic porous magnesium oxide with the same structure is formed by thermal oxidation of the cubic porous Mg-MOF, which not only maintains the nanoscale particle size of Mg-MOF but also maintains the porous structure, so that the cubic porous magnesium oxide has good adsorption capacity and extremely small particle size, which is more conducive to the rapid relief of rumen acidosis symptoms.

[0046] S2. Dissolve sodium selenite and sodium selenate in deionized water in equal proportions to prepare a tin salt solution with a selenium concentration of 5 mg / L, place 15 g of cubic porous magnesium oxide in 8 L of the tin salt solution, adjust the pH value to 11 with concentrated hydrochloric acid, stir and adsorb for 4 h, filter and vacuum dry to obtain selenium-loaded magnesium oxide.

[0047] The adsorption properties of cubic porous magnesium oxide are utilized to adsorb selenate to obtain selenium-loaded magnesium oxide. The hydrolysis and decomposition of the selenium-loaded magnesium oxide in gastric acid promotes the desorption of selenate and its absorption by livestock, thereby increasing the selenium content and thus improving the immunity of livestock.

[0048] S3. In a reaction kettle, add 60 g corn starch into 6 L deionized water, add 150 g potassium periodate dropwise, raise the temperature to 60° C. and stir to react for 3 h. After standing for 48 h, filter, wash the precipitate with deionized water, and vacuum dry to obtain dialdehyde starch.

[0049] S4. In a reactor, 50 g of dialdehyde starch was mixed with 300 mL of ethanol, 15 g of sulfathiazole was added, and the mixture was refluxed to 60° C. for 48 h. After filtering, the mixture was washed with deionized water and ethanol, and vacuum dried to obtain a starch-based Schiff base.

[0050] Potassium periodate is used to oxidatively cleave starch molecules to form dialdehyde starch with high reactivity. The condensation reaction of the aldehyde group of dialdehyde starch and sulfathiazole is used to form starch-based Schiff base. The starch-based Schiff base reacts with gastric acid in the rumen to decompose and produce sulfathiazole. Sulfathiazole is used to treat subacute ruminal acidosis and effectively relieves the symptoms of ruminal acidosis.

[0051] S5. In a reactor, 40 g of starch-based Schiff base was mixed with 300 mL of deionized water to prepare a starch suspension, 0.6 g of selenium-loaded magnesium oxide was ultrasonically dispersed in 25 g of wheat germ oil to obtain an oil suspension, 25 g of the oil suspension was added to the reactor, the temperature was raised to 80° C. and stirred for 30 min, the mixture was cooled and vacuum dried at 90° C. for 6 h, the mixture was crushed, and the mixture was sieved to obtain a feed additive for alleviating rumen acidosis in ruminants.

[0052] The selenium-loaded magnesium oxide is dispersed in wheat germ oil, and the wheat germ oil is combined with the starch chain in the starch-based Schiff base through hydrophobic interaction to form a crystal structure. As a vegetable oil, the wheat germ oil can provide necessary fatty acids and energy for livestock, which is helpful for their growth and development. After the feed additive prepared by the present invention is eaten by livestock along with the feed, the starch-based Schiff base begins to decompose in the acidic environment in the rumen, and sulfathiazole is produced to relieve the symptoms of rumen acidosis, which synergizes with the selenium-loaded magnesium oxide in the wheat germ oil, has high relief efficiency and fast relief speed. When the surface of magnesium oxide begins to hydrate, magnesium ions are released and concentrated in the interlayer of magnesium hydroxide to generate positive charges, which attract selenium salts in magnesium oxide to the surface of magnesium oxide through electrostatic force, so that selenate is released and absorbed. Supplementation of selenate can improve the growth rate and feed utilization rate of livestock. Selenium is a component of glutathione peroxidase, has an antioxidant effect, and protects cells from oxidative damage. Supplementation of selenate can improve the immunity of livestock and reduce the recurrence of rumen acidosis.

[0053] Comparative Example 1: The difference from Example 1 is that in S2, cubic porous magnesium oxide is replaced by magnesium oxide nanoparticles of equal mass to prepare a feed additive for alleviating rumen acidosis in ruminants.

[0054] Comparative Example 2: The difference from Example 1 is that in S5, the selenium-loaded magnesium oxide is replaced by cubic porous magnesium oxide of equal mass to prepare a feed additive for alleviating rumen acidosis in ruminants.

[0055] Comparative Example 3: The difference from Example 1 is that in S5, corn starch and sulfathiazole are used to replace starch-based Schiff base to prepare a feed additive for alleviating rumen acidosis in ruminants.

[0056] The performance of the feed additives for alleviating rumen acidosis of ruminants prepared in Examples 1 to 3 and Comparative Examples 1 to 3 was tested, and the test method was as follows: the test breed was Saanen black goats, which had no previous digestive system diseases and had not been recently exposed to antibiotics or anthelmintics. The test goats were 4 years old and weighed 30-34 kg. They secreted goat milk twice a day on average, and were fed a feed containing the following components in percentage: 40 wt% hay, 32 wt% corn flour, 8 wt% soybean meal, 2 wt% limestone, 1 wt% salt and 1 wt% mineral mixture (the mineral mixture included niacin, manganese, zinc, iron, copper, selenium, iodine, cobalt, vitamins Vitamin E, vitamin D and vitamin A), 40wt% of hay was changed to 20wt% corn flour and 20wt% hay to induce rumen acidosis in the test sheep, and the control group ck was set to be fed with the original feed ratio. After one week of feeding, the initial daily milk production of the test sheep was weighed, gastric juice was collected non-invasively with a stomach tube, and the initial stomach pH value was measured. Then, 0.5wt% of the feed additive for alleviating rumen acidosis of ruminants prepared in Example 1-Example 3 and Comparative Example 1-Comparative Example 3 was added to the test sheep feed, and the hay ratio was restored to 40wt%. After continuous feeding for one week, the daily milk production of the test sheep after treatment was weighed, and the stomach pH value after treatment was measured. The results are shown in Table 1:

[0057] Table 1 Goat milk production and stomach pH test results

[0058]

[0059] It can be seen from Table 1 that the feed additive for alleviating rumen acidosis of ruminants prepared by the present invention, after being added to feed for feeding, significantly restored milk production and stomach pH value compared with the control group ck, indicating that the feed additive for alleviating rumen acidosis of ruminants prepared by the present invention has good gastric acid neutralization ability, fast recovery speed and good recovery degree.

[0060] In Comparative Example 1, since the magnesium oxide nanoparticles do not have a porous structure, the adsorption amount of selenate is small, the selenium content in the additive is low, and the immunity of goats is slightly improved.

[0061] In Comparative Example 2, since selenium is not loaded in the cubic porous magnesium oxide, the cubic porous magnesium oxide has a high porosity and a large contact area with gastric acid at the same mass, and the neutralization effect on gastric acid is better and faster than that in Comparative Example 1, so the goats have a better recovery degree.

[0062] In Comparative Example 3, since corn starch was not modified and then cross-linked with sulfathiazole, sulfathiazole was insoluble in deionized water, had low dispersion when preparing the feed additive, and the synergistic effect with selenium-loaded magnesium oxide was greatly reduced, resulting in minimal recovery effect on goats.

[0063] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A production process for a feed additive for alleviating rumen acidosis in ruminants, characterized in that: The steps include: In a reaction kettle, starch-based Schiff base is mixed with deionized water to prepare a starch suspension, the oil suspension is added to the reaction kettle, the temperature is raised to 70-80° C., and stirred for 20-30 minutes, and after cooling, vacuum drying, crushing, and sieving to obtain a feed additive for alleviating rumen acidosis in ruminants; The oil suspension is prepared by ultrasonically dispersing selenium-loaded magnesium oxide in wheat germ oil; The usage ratio of the selenium-loaded magnesium oxide and wheat germ oil is 0.3-0.6 g:15-25 g; The loaded selenium magnesium oxide is prepared by the following steps: The cubic porous magnesium oxide was placed in a 5 mg / L tin salt solution, the pH value was adjusted to 10-11 with concentrated hydrochloric acid, and the mixture was stirred and adsorbed for 3-4 hours, and then vacuum dried after filtration to obtain the selenium-loaded magnesium oxide; The tin salt solution is prepared by dissolving sodium selenite and sodium selenate in deionized water in equal proportions.

2. The production process of the feed additive for alleviating rumen acidosis in ruminants according to claim 1, characterized in that: The usage ratio of the starch-based Schiff base, deionized water and oil suspension is 20-40 g: 200-300 mL: 15-25 g.

3. The production process of the feed additive for alleviating rumen acidosis in ruminants according to claim 1, characterized in that: The usage ratio of the cubic porous magnesium oxide and the selenium salt solution is 10-15 g: 5-8 L.

4. The production process of the feed additive for alleviating rumen acidosis in ruminants according to claim 3, characterized in that: The cubic porous magnesium oxide is prepared by the following steps: Dissolve 2-methylimidazole and magnesium chloride hexahydrate in N, N-dimethylformamide in a reaction kettle, stir and mix, heat to 130-150° C. and stir to react for 20-24 hours, collect the precipitate by centrifugation, wash the precipitate with methanol and N, N-dimethylformamide, vacuum dry it at 60-70° C. for 12-14 hours, grind it with agate for 1-2 minutes, place it in a muffle furnace, heat to 550-600° C. and calcine it for 12-14 hours to obtain cubic porous magnesium oxide.

5. The production process of the feed additive for alleviating rumen acidosis in ruminants according to claim 4, characterized in that: The usage ratio of the 2-methylimidazole, magnesium chloride hexahydrate and N,N-dimethylformamide is 8-10g:20-25g:1.2-1.4L.

6. The production process of the feed additive for alleviating rumen acidosis in ruminants according to claim 1, characterized in that: The starch-based Schiff base is prepared by the following steps: The dialdehyde starch and ethanol are mixed in a reaction kettle, sulfathiazole is added, and the mixture is refluxed and heated to 50-60° C. for reaction for 40-48 hours. The mixture is filtered, washed with deionized water and ethanol, and vacuum dried to obtain a starch-based Schiff base.

7. The production process of the feed additive for alleviating rumen acidosis in ruminants according to claim 6, characterized in that: The dosage ratio of the dialdehyde starch, ethanol and sulfathiazole is 30-50g: 200-300mL: 10-15g.

8. The production process of the feed additive for alleviating rumen acidosis in ruminants according to claim 7, characterized in that: The dialdehyde starch is prepared by the following steps: In a reaction kettle, corn starch is added into deionized water, potassium periodate is added dropwise, the temperature is raised to 50-60° C., stirred for reaction for 2-3 hours, allowed to stand for 40-48 hours, filtered, the precipitate is washed with deionized water, and vacuum dried to obtain dialdehyde starch.

9. The production process of the feed additive for alleviating rumen acidosis in ruminants according to claim 8, characterized in that: The usage ratio of the corn starch, deionized water and potassium periodate is 50-60g:5-6L:100-150g.

10. A feed additive for alleviating rumen acidosis in ruminants, characterized in that: The feed additive is prepared by the production process of the feed additive for alleviating rumen acidosis in ruminants according to any one of claims 1 to 9.

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