Composite selenium-rich soft-shelled turtle oil soft capsule functional food and preparation method thereof

Abstract

The invention discloses a selenium-rich composite oil-based soft capsule preparation and a preparation method thereof. The method comprises the following steps: compounding molecular distillation selenium-rich soft-shelled turtle oil, enzyme modified flaxseed diester oil and high-tocopherol wheat germ oil according to a specific ratio, and combining with a gradient mixing-high pressure homogenization-nano emulsification triple process, so as to prepare an oil-based system with a synergistic anti-oxidation function. The product significantly improves the bioavailability of selenium element, the retention rate of omega-3 fatty acid is greater than or equal to 95%, and the product is suitable for health maintenance of heart and cerebral vessels of middle-aged and elderly people. The core innovation point is that efficient delivery of micronutrients is realized through oil phase polarity regulation and control.

Description

Technical Field

[0001] The invention relates to the technical field of functional foods, and in particular to a composite turtle oil-based soft capsule preparation with synergistic nutritional enhancement function and a preparation process thereof. Background Art

[0002] Currently, commercially available fish oil products generally have the problem of ω-3 fatty acids being easily oxidized and having low bioavailability. Although turtle oil is rich in selenium, it has difficulties in preservation and low utilization rate. The existing compound oil technology uses microencapsulation technology but does not solve the problem of multi-phase oil compatibility. The present invention achieves stable and effective nutritional ingredients by combining compounding in a specific ratio with a secondary emulsification process. Summary of the invention Technical issues

[0003] 1. A single oil source is nutritionally unbalanced.

[0004] 2. Highly unsaturated fatty acids are prone to oxidation and deterioration.

[0005] 3. The bioavailability of selenium is low. Technical Solution

[0006] Core formula: Selenium-rich turtle oil (purified by molecular distillation, selenium content 50-100μg / g) 20-40%.

[0007] Flaxseed diester oil (prepared by enzymatic transesterification, α-linolenic acid ≥ 50%) 30-50% Wheat germ oil (tocopherol content ≥ 2000mg / kg) 15-30% Compound antioxidant (rosemary extract + vitamin E, mass ratio 1:2) 0.5-1.5%.

[0008] Preparation method: 1. Mix by gradient heating: add turtle oil at 30℃ → add linseed diester oil at 40℃ → add wheat germ oil at 50℃.

[0009] 2. High-pressure homogenization: Three-stage homogenization (20MPa→35MPa→50MPa) is carried out under nitrogen protection.

[0010] 3. Nanoemulsification: Add lecithin / chitosan composite emulsifier (particle size ≤ 200nm).

[0011] 4. Soft capsule pressing: using the rotary die method, the moisture content of the rubber is controlled at 8-12%.

[0012] Beneficial effects: 1. Selenium bioavailability increased by 38%.

[0013] 2. The peroxide value is reduced to below 0.02g / 100g.

[0014] 3. The in vitro simulated digestibility increased to 92%. DETAILED DESCRIPTION Example

[0015] Formula: 25% selenium-rich turtle oil, 45% linseed diester oil, 28% wheat germ oil, and 1.2% compound antioxidant.

[0016] Process parameters: secondary homogenization pressure 40MPa, emulsification temperature 55℃, gelatin / glycerol ratio 6:1.

[0017] Experimental data: Accelerated oxidation test (60℃ / 14 days): peroxide value 0.015g / 100g.

[0018] Feeding experiment in SD rats: serum selenium level increased by 42% compared with the control group (p<0.01).

[0019] The applicable population and core functions of the product of the present invention are as follows: 1. Applicable people 1. Middle-aged and elderly people α-linolenic acid (ALA) in flaxseed diester oil can be converted into EPA / DHA to help regulate blood lipids and maintain vascular elasticity.

[0020] Selenium-rich turtle oil provides organic selenium forms (such as selenomethionine), enhances the activity of antioxidant enzymes, and prevents atherosclerosis.

[0021] 2. People with three highs (high blood pressure / high blood lipids / high blood sugar).

[0022] The ω-3 / ω-6 ratio in the compound oil is optimized to 1:1-1:3, which synergistically inhibits the release of inflammatory factors (such as TNF-α and IL-6).

[0023] Gamma-tocopherol in wheat germ oil can improve insulin sensitivity.

[0024] 3. People with sub-health or low immunity Selenium enhances the antioxidant capacity of cells by activating the GPx enzyme system.

[0025] Chitosan emulsifier has intestinal immunomodulatory function.

[0026] 4. People who do mental work and overuse their eyes -DHA precursors support the integrity of nerve cell membranes.

[0027] Vitamin E protects the retinal photoreceptor cells.

[0028] 2. Main functions 1. Synergistic Antioxidant Selenium (turtle oil) and vitamin E (wheat germ oil) form a "redox cycle chain", and the free radical scavenging efficiency is increased by 60% compared to a single component.

[0029] 2. Cardiovascular and cerebrovascular protection Flaxseed diester oil reduces serum triglycerides (reduction ≥ 15%), and selenium-rich components inhibit oxidative damage to the vascular endothelium.

[0030] 3. Efficient delivery of micronutrients Nanoemulsification technology makes selenium bioavailability reach 78% (compared to 40-50% of ordinary fish oil preparations) The absorption rate of secondary esterified flaxseed oil in the small intestine increases by 2.3 times.

[0031] 4. Metabolic Regulation The phytosterols (wheat germ oil) and diester oil in the compound oil synergistically inhibit cholesterol absorption.

[0032] Selenium-dependent thyroxine deiodinase regulates basal metabolic rate.

[0033] 3. Adaptability to special populations Crowd type adaptation basis Vegetarian plant-based flaxseed oil + wheat germ oil account for ≥ 60%, meeting plant-based nutritional requirements Molecular distillation process for people sensitive to heavy metals reduces lead / arsenic residues in turtle oil to less than 0.01ppm For patients with dysphagia, the diameter of the soft capsule is ≤8mm and the disintegration time of the rubber is <15 minutes.

[0034] 4. Function Implementation Path [Selenium-rich turtle oil] --> B (provides organic selenium + phospholipids) C[linseed diester oil] --> D(ω-3 precursor + quick energy supply)E[wheat germ oil] --> F(vitamin E + phytosterols) B & D & F --> [Synergistic Antioxidant Network] G --> H{Core Function} H --> I [delays LDL oxidation] H --> J [Inhibit excessive platelet aggregation] H --> K [reduces mitochondrial ROS generation].

Claims

1. A functional compound oil composition, characterized in that Contains the following components in percentage by weight: 20-40% selenium-enriched turtle oil, 30-50% linseed diester oil, 15-30% wheat germ oil, and 0.5-1.5% compound antioxidant; the selenium-enriched turtle oil is purified by molecular distillation, and the selenium content is 50-100 μg / g; the linseed diester oil is prepared by lipase-catalyzed ester exchange method, and the α-linolenic acid content is ≥50%.

2. The composition according to claim 1, characterized in that The composite antioxidant is composed of rosemary extract and vitamin E in a mass ratio of 1:1-3.

3. A method for preparing the composition according to any one of claims 1 to 2, comprising the following steps: a) Gradient mixing: Under nitrogen protection, add each oil phase in stages according to 30℃→40℃→50℃; b) High-pressure homogenization: three-stage progressive homogenization with a pressure range of 20-50MPa; c) Nanoemulsification: Add lecithin / chitosan composite emulsifier accounting for 1-3% of the total oil phase and control the particle size to ≤200nm.

4. The method according to claim 3, characterized in that In step b), the mixture needs to be precooled to 4-10°C before homogenization and the temperature difference should be kept ≤2°C.

5. A functional soft capsule preparation, characterized in that The composition according to claims 1-2 is used as the content, the rubber is made of gelatin, glycerin and water in a mass ratio of 6:1:3, and the content filling amount is 500-800 mg / pill.