Composite embedded vitamin liposome as well as preparation method and application thereof

By combining ethanol injection and spray drying processes, the composite embedded vitamin liposomes with high-purity plant-source phospholipids are optimized, which solves the problem of low stability and bioavailability of vitamin preparations in the food industry, and achieves efficient embedding and stable release, which is suitable for industrial production of a variety of food dosage forms.

CN120360269APending Publication Date: 2025-07-25INNOBIO CORP LTD
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Patent Information

Application Number
CN202411938946.2
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-26
Publication Date
2025-07-25

AI Technical Summary

Technical Problem

The existing vitamin preparations have problems with poor stability and low bioavailability in the food industry, especially in the mixed applications of water-soluble and fat-soluble vitamins. The existing liposome preparation methods have limitations in particle size control, stability and production efficiency, which are difficult to meet the needs of large-scale production.

Method used

An innovative method combining ethanol injection process and spray drying process is adopted to prepare composite embedded vitamin liposomes with good fluidity, small particle size and high embedding rate by optimizing the formulation combination. High-purity natural plant-source phospholipids and membrane stabilizers are used to ensure the physical and chemical stability of the product and simplify the production process.

Benefits of technology

It achieves efficient embedding and stable release of vitamins, improves bioavailability, simplifies production processes, reduces costs, is suitable for industrial production of various food dosage forms, and complies with the regulations of the food processing industry.

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Abstract

The invention discloses a composite embedded vitamin liposome as well as a preparation method and application thereof, by optimizing a formula and a process, adopting high-purity natural plant source phospholipid, a proper amount of a wall material and a membrane stabilizer and combining an antioxidant, the vitamin retention rate exceeds 95% after the liposome is accelerated at 60 DEG C for 20 days, and the rehydration particle size is between 200 and 800nm; the flowability is good, no bad taste or smell exists, and efficient embedding and stable release of vitamins are realized. The liposome has excellent physical and chemical stability and is suitable for various dosage forms such as tablets and hard-shell capsules, and the bioavailability and market application value of the product are remarkably improved. In addition, a clean solvent ethanol is used in the preparation process and is effectively removed and recycled, so that the method meets the requirements of food processing industry laws and regulations, is environment-friendly and is suitable for large-scale production.
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