Electroencephalogram fluctuation signal acquisition and analysis system and brain fluctuation graph instrument

Abstract

The invention discloses an electroencephalogram fluctuation signal acquisition and analysis system and an electroencephalogram fluctuation graph, and the electroencephalogram fluctuation signal acquisition and analysis system comprises an electroencephalogram signal acquisition module which is used for acquiring electroencephalogram signals of a tested person; the electroencephalogram signal processing module is used for performing power spectrum analysis and electroencephalogram power fluctuation signal analysis on spectrum systems corresponding to the six neurochemical transmitters according to the electroencephalogram signals; the six neurochemical transmitters are Y-aminobutyric acid, glutamic acid, 5-hydroxytryptamine, acetylcholine, dopamine and noradrenaline; and the analysis result expression module is used for generating a neurotransmitter distribution map, an alpha-wave competition map, an entropy value, a brain function evaluation map, an original electroencephalogram and a three-dimensional electroencephalogram topographic map according to the results of the power spectrum analysis and the electroencephalogram power fluctuation signal analysis. According to the electroencephalogram fluctuation signal acquisition and analysis system provided by the invention, various information graphs of the brain region can be obtained, the content of a detection report is detailed, and images and texts are rich, so that a doctor is helped to noninvasively monitor 23 encephalopathy related to neurotransmitters.

Description

Technical Field

[0001] The present application relates to the field of medical device technology, and in particular to a brain wave fluctuation signal acquisition and analysis system and a brain wave fluctuation instrument. Background Art

[0002] Encephalofuctuograph (EFG) is a medical device used to detect brain function. It works by analyzing the dynamic changes of neurotransmitters and ultra-slow waves in the brain. This device can play an important role in the diagnosis of neurological diseases, testing the efficacy, selecting new drugs and treatment plans. It can detect a variety of diseases such as headaches, dizziness, Parkinson's disease, neurasthenia, cerebrovascular disease, epilepsy, etc., and is also very useful for the diagnosis and treatment guidance of mental illnesses.

[0003] The patent document with the publication number CN1632816A discloses a method for analyzing EEG fluctuation signals applied to a brain fluctuation graph. The method first divides the EEG signal data into segments according to a certain time length, performs power spectrum analysis on each segment of data, and selects the maximum power amplitude in the range of 0.5-50Hz, performs multiple power spectrum analysis and spectrum analysis, obtains a power spectrum fluctuation graph within the ultra-slow wave range, and then performs a series of analyses on the fluctuation graph to obtain a series of data parameters and display them in the form of numerical values, graphs and curves. However, this method can only display brain area data in the form of simple numerical values, graphs and curves, resulting in fewer types of diseases that doctors can judge.

[0004] In addition, the existing brain fluctuation graph is relatively large in size, and the structure of the brain fluctuation graph body and the layout of various components are not reasonable, resulting in inconvenience in use. Summary of the invention

[0005] To this end, the present application provides an EEG fluctuation signal acquisition and analysis system and a brain fluctuation graph to solve the problem that the brain fluctuation graph analysis method in the prior art can only display brain area data in the form of simple numerical values, graphics and curves.

[0006] In order to achieve the above objectives, this application provides the following technical solutions:

[0007] In a first aspect, a system for collecting and analyzing electroencephalogram fluctuation signals comprises:

[0008] An EEG signal acquisition module is used to acquire EEG signals of the subject;

[0009] An EEG signal processing module, for performing power spectrum analysis and EEG power fluctuation signal analysis on the spectrum corresponding to six neurochemical transmitters according to the EEG signal; the six neurochemical transmitters are γ-aminobutyric acid, glutamate, 5-hydroxytryptamine, acetylcholine, dopamine and norepinephrine;

[0010] The analysis result expression module is used to generate a neurotransmitter distribution map, an alpha wave competition map and entropy value, a brain function evaluation map, an original electroencephalogram and a three-dimensional electroencephalogram according to the results of the power spectrum analysis and the electroencephalogram power fluctuation signal analysis.

[0011] Preferably, the acquisition module adopts 16 leads of the international standard lead system and 19 brain electrode wires, among which FP1, F7, F3, T3, C3, T5, P3, O1 for the left brain and FP2, F8, F4, T4, C4, T6, P4, O2 for the right brain, the left ear electrode is inserted into A1, the right ear electrode is inserted into A2, and the reference ground is inserted into Gnd.

[0012] Preferably, the neurotransmitter distribution diagram is represented by a bar graph, with different colors representing different states, and intuitively displaying normal values ​​and measured values.

[0013] Preferably, the brain function evaluation chart is used to show whether the brain is hypoxic, fatigued, excited, inhibited and reversed.

[0014] Preferably, the EEG signal processing module is also used to determine the relationship between the six neurochemical transmitters and human biological characteristics, and to provide nutritional advice.

[0015] In the second aspect, a brain fluctuation graph includes a trolley, which includes a base, an inclined support rod and a plurality of movable wheels, wherein the plurality of movable wheels are fixedly arranged on the lower surface of the base, the inclined support rod is fixedly arranged on the upper surface of the base, and the upper surface of the base is divided into a first area and a second area, the area of ​​the first area is larger than that of the second area, the inclined support rod is located above the first area, and a chamber and a workbench are fixedly arranged in sequence from bottom to top, the second area is used to place a host, and the workbench is used to place a display, a keyboard and a mouse, an electroencephalogram signal acquisition device is movably arranged on the side of the workbench, and the host is integrated with the electroencephalogram fluctuation signal acquisition and analysis system described in any one of claims 1 to 5.

[0016] Preferably, the workbench comprises a first workbench and a second workbench, the first workbench and the second workbench are fixedly connected via a connecting column, the first workbench is used for placing a keyboard and a mouse, and the second workbench is used for placing a monitor.

[0017] Preferably, it also includes a movable connecting piece, which includes a connecting piece, a first connecting rod and a second connecting rod, one end of the connecting piece is fixedly connected to the end of the connecting column, the side of the connecting piece is connected to one end of the first connecting rod, the other end of the first connecting rod is movably connected to one end of the second connecting rod, and the other end of the second connecting rod is fixedly connected to the EEG signal acquisition device.

[0018] Preferably, a fixing device is provided in the second area, and the host is detachably placed in the fixing device through the fixing device.

[0019] Preferably, the fixing device includes a fixing plate and a strap, wherein a side edge of the fixing plate is fixedly arranged on an edge of the second area, one end of the strap is fixedly arranged on another side edge of the fixing plate, and the other end of the strap is fixedly arranged on the inclined support rod.

[0020] Compared with the prior art, this application has at least the following beneficial effects:

[0021] The present application provides a brain wave fluctuation signal acquisition and analysis system, including: a brain wave fluctuation signal acquisition module for collecting brain wave signals of the subject; a brain wave fluctuation signal processing module for performing power spectrum analysis and brain wave power fluctuation signal analysis on the spectrum corresponding to six neurochemical transmitters according to the brain wave signals; the six neurochemical transmitters are γ-aminobutyric acid, glutamate, 5-hydroxytryptamine, acetylcholine, dopamine and norepinephrine; an analysis result expression module for generating a neurotransmitter distribution map, an α wave competition map and entropy value, a brain function evaluation map, an original electroencephalogram and a three-dimensional brain wave topography map according to the results of power spectrum analysis and brain wave power fluctuation signal analysis. The brain wave fluctuation signal acquisition and analysis system provided by the present application can scan the distribution of various transmitters through a single test, and obtain various information maps of brain regions, so that the test report is detailed and rich in pictures and texts, thereby helping doctors to non-invasively monitor up to 23 brain diseases related to neurotransmitters.

[0022] The present application also provides a brain fluctuation graph, including a trolley, the trolley includes a base, an inclined support rod and a plurality of moving wheels, the plurality of moving wheels are fixedly arranged on the lower surface of the base, the inclined support rod is fixedly arranged on the upper surface of the base, and the upper surface of the base is divided into a first area and a second area, the area of ​​the first area is larger than the second area, the inclined support rod is located above the first area, and a chamber and a workbench are fixedly arranged from bottom to top in sequence, the second area is used to place a host, the workbench is used to place a display, a keyboard and a mouse, and an electroencephalogram signal acquisition device is movably arranged on the side of the workbench. The brain fluctuation graph provided by the present application is small in size, and the structure of the brain fluctuation graph body and the layout of each component are more reasonable, and it is convenient to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] In order to more intuitively illustrate the prior art and the present application, exemplary drawings are given below. It should be understood that the specific shapes and structures shown in the drawings should not generally be regarded as limiting conditions for implementing the present application; for example, those skilled in the art are capable of easily making conventional adjustments or further optimizations to the addition / reduction / attribution division, specific shapes, positional relationships, connection methods, dimensional ratios, etc. of certain units (components) based on the technical concepts and exemplary drawings disclosed in the present application.

[0024] Figure 1 A schematic diagram of the placement structure of the brain electrode wire provided in Example 1 of the present application;

[0025] Figure 2 A schematic diagram of the structure of a brain fluctuation instrument provided in Example 2 of the present application.

[0026] Description of reference numerals:

[0027] 1. Trolley; 101. Base; 102. Tilt support rod; 103. Moving wheel; 2. Chamber; 3. Workbench; 301. First workbench; 302. Second workbench; 303. Connecting column; 4. Host; 5. Display; 6. Keyboard; 7. Mouse; 8. EEG signal acquisition device; 9. Movable connecting piece; 901. Connecting piece; 902. First connecting rod; 903. Second connecting rod; 10. Fixing device; 1001. Fixing plate; 1002. Strap. DETAILED DESCRIPTION

[0028] The present application is further described below in detail through specific embodiments in conjunction with the accompanying drawings.

[0029] In the description of this application: unless otherwise specified, the meaning of "plurality" is two or more. The terms "first", "second", "third", etc. in this application are intended to distinguish the objects referred to, and do not have special meanings in terms of technical connotations (for example, they should not be understood as emphasizing the importance or order, etc.). Expressions such as "including", "comprising", "having", etc. also mean "not limited to" (certain units, components, materials, steps, etc.).

[0030] The terms such as "upper", "lower", "left", "right", "middle", etc. cited in this application are usually used to indicate the general relative position relationship for the purpose of intuitive understanding by referring to the drawings, and are not absolute limitations on the position relationship in the actual product.

[0031] Embodiment 1

[0032] This embodiment provides a system for collecting and analyzing EEG fluctuation signals, including:

[0033] An EEG signal acquisition module is used to acquire EEG signals of the subject;

[0034] The EEG signal processing module is used to perform power spectrum analysis and EEG power fluctuation signal analysis on the spectrum corresponding to six neurochemical transmitters according to the EEG signals; the six neurochemical transmitters are GABA (γ-aminobutyric acid), GLu (glutamate), 5-HT (5-hydroxytryptamine), ACh (acetylcholine), DA (dopamine) and NE (norepinephrine);

[0035] The analysis result expression module is used to generate neurotransmitter distribution maps, α wave competition maps and entropy values, brain function evaluation maps, original EEGs and three-dimensional EEG topographic maps based on the results of power spectrum analysis and EEG power fluctuation signal analysis.

[0036] For details, please refer to Figure 1 In this embodiment, the acquisition module adopts 16 leads of the international standard lead system and 19 brain electrode wires, among which FP1, F7, F3, T3, C3, T5, P3, O1 are used for the left brain, and FP2, F8, F4, T4, C4, T6, P4, O2 are used for the right brain. The left ear electrode is inserted into A1, the right ear electrode is inserted into A2, and the reference ground is inserted into Gnd.

[0037] After the acquisition module collects the EEG signals using the 16-lead international standard lead system, it transmits the collected EEG signals to the digital EEG signal amplifier through the brain electrode line. The digital EEG signal amplifier receives the EEG signals, amplifies the signals, performs digital-to-analog conversion, and digitally filters them before sending them to the EEG signal processing module. The EEG signal processing module performs power spectrum analysis and EEG power fluctuation signal analysis on the spectrum corresponding to the six neurochemical transmitters based on the EEG signals.

[0038] More specifically, power spectrum analysis includes the following steps:

[0039] (1) Perform power spectrum analysis on the time domain EEG signal of a given time length, that is, observe the N-point data x of the EEG signal x(n) N (n) Directly perform Fourier transform to obtain X N (e jω );

[0040] (2) Take the square of its amplitude and divide it by N to obtain the square of x. N The real power spectrum P(e) of (n) jω ), the power spectrum estimated by the periodogram method can be expressed as:

[0041]

[0042] (3)X N The calculation of (ω) is obtained by fast Fourier transform:

[0043]

[0044] The power spectrum can be expressed as:

[0045]

[0046] EEG power fluctuation signal analysis includes:

[0047] (1) Select a window function with a small side lobe amplitude and fast decay, expressed as:

[0048]

[0049] Then the EEG signal x(n) data is truncated to obtain:

[0050] x N (n) = x(n)ω(n);

[0051] (2) For the above signal x N (n) = x(n)ω(n) for power spectrum analysis, with a sampling time of T seconds. The frequency domain resolution of the spectrum obtained by FFT is 1 / T, and the power amplitude p with the largest energy and the corresponding frequency f are selected;

[0052] (3) The time domain EEG signal with a total time length of N seconds is segmented into T seconds in chronological order, and the conventional power spectrum analysis and EEG power fluctuation signal analysis are performed on the N / T segment data in turn to obtain the maximum power amplitude fluctuation signal p(n) and the corresponding frequency fluctuation signal f(n), n = 1...n, n = N / T. It represents the fluctuation process of power and the corresponding maximum amplitude in the total time.

[0053] For more specific power spectrum analysis and EEG power fluctuation signal analysis processes, please refer to patent document with publication number CN1632816A, which will not be described in detail here.

[0054] Specifically, the neurotransmitter distribution diagram is presented in the form of a bar graph, with different colors representing different states, and normal values ​​and measured values ​​are intuitively displayed.

[0055] Specifically, brain function evaluation charts are used to show whether the brain is suffering from hypoxia, fatigue, excitation inhibition, and reversal.

[0056] Specifically, the EEG signal processing module is also used to determine the relationship between the six neurochemical transmitters and human biological characteristics, and to provide nutritional advice.

[0057] The present embodiment provides an EEG fluctuation signal acquisition and analysis system, which acquires the EEG signals of the subject through an EEG signal acquisition module, and uses an EEG signal processing module to perform power spectrum analysis and EEG power fluctuation signal analysis on the spectrum corresponding to six neurochemical transmitters based on the EEG signals. Finally, an analysis result expression module generates a neurotransmitter distribution map, an α wave competition map and entropy value, a brain function evaluation map, an original EEG and a three-dimensional EEG topographic map based on the results of the power spectrum analysis and the EEG power fluctuation signal analysis.

[0058] The EEG fluctuation signal acquisition and analysis system provided in this embodiment can scan the distribution of various neurotransmitters through a single test and obtain various information maps of brain areas. The test report is detailed and rich in pictures and texts, thereby helping doctors to non-invasively monitor 23 brain diseases related to neurotransmitters. The 23 brain diseases include aging, Alzheimer's disease, cerebral atrophy, neurasthenia, Parkinson's disease, writer's cramp, chorea, attention deficit hyperactivity disorder, myasthenia gravis, epilepsy, cerebral ischemia, dizziness, vertigo, headache, migraine, schizophrenia, mania, depression, hypoxic encephalopathy, hepatic encephalopathy, endocrine disorders, etc.

[0059] Embodiment 2

[0060] See also Figure 2 The present embodiment provides a brain fluctuation graph, including a trolley 1, the trolley 1 includes a base 101, an inclined support rod 102 and a plurality of moving wheels 103, wherein four moving wheels 103 are provided, and the four moving wheels 103 are fixedly arranged on the lower surface of the base 101, and the inclined support rod 102 is fixedly arranged on the upper surface of the base 101, and the upper surface of the base 101 is divided into a first area and a second area, the area of ​​the first area is larger than the second area, and the inclined support rod 102 is located above the first area. A chamber 2 and a workbench 3 are fixedly arranged from bottom to top in sequence, the second area is used to place a host 4, and the workbench 3 is used to place a display 5, a keyboard 6 and a mouse 7. An electroencephalogram signal acquisition device 8 is movably arranged on the side of the workbench 3, and the host 4 is integrated with the electroencephalogram fluctuation signal acquisition and analysis system provided in the first embodiment.

[0061] Specifically, the workbench 3 includes a first workbench 301 and a second workbench 302 . The first workbench 301 and the second workbench 302 are fixedly connected via a connecting column 303 . The first workbench 301 is used to place the keyboard 6 and the mouse 7 , and the second workbench 302 is used to place the display 5 .

[0062] Specifically, a brain fluctuation graph provided in this embodiment also includes a movable connecting member 9, which includes a connecting member 901, a first connecting rod 902 and a second connecting rod 903. One end of the connecting member 901 is fixedly connected to the end of the connecting column 303, the side of the connecting member 901 is connected to one end of the first connecting rod 902, the other end of the first connecting rod 902 is movably connected to one end of the second connecting rod 903, and the other end of the second connecting rod 903 is fixedly connected to the EEG signal acquisition device 8.

[0063] Specifically, a fixing device 10 is disposed in the second area, and the host 4 is detachably placed in the fixing device 10 through the fixing device 10 .

[0064] More specifically, the fixing device 10 includes a fixing plate 1001 and a strap 1002 , wherein the side of the fixing plate 1001 is fixedly set on the edge of the second area, one end of the strap 1002 is fixedly set on the other side of the fixing plate 1001 , and the other end of the strap 1002 is fixedly set on the inclined support rod 102 .

[0065] The brain fluctuation graph provided in this embodiment has a small size, and the structure of the brain fluctuation graph body and the layout of each component are more reasonable, and it is convenient to use.

[0066] The technical features of the above embodiments may be arbitrarily combined (as long as there is no contradiction in the combination of these technical features). To make the description concise, not all possible combinations of the technical features in the above embodiments are described; these embodiments that are not explicitly written should also be considered to be within the scope of this specification.

Claims

1. A brain wave fluctuation signal acquisition and analysis system, characterized in that: include: An EEG signal acquisition module is used to acquire EEG signals of the subject; An EEG signal processing module, for performing power spectrum analysis and EEG power fluctuation signal analysis on the spectrum corresponding to six neurochemical transmitters according to the EEG signal; the six neurochemical transmitters are γ-aminobutyric acid, glutamate, 5-hydroxytryptamine, acetylcholine, dopamine and norepinephrine; The analysis result expression module is used to generate a neurotransmitter distribution map, an alpha wave competition map and entropy value, a brain function evaluation map, an original electroencephalogram and a three-dimensional electroencephalogram according to the results of the power spectrum analysis and the electroencephalogram power fluctuation signal analysis.

2. The EEG fluctuation signal acquisition and analysis system according to claim 1, characterized in that: The acquisition module adopts 16 leads of the international standard lead system and 19 brain electrode wires, among which FP1, F7, F3, T3, C3, T5, P3, O1 for the left brain and FP2, F8, F4, T4, C4, T6, P4, O2 for the right brain. The left ear electrode is inserted into A1, the right ear electrode is inserted into A2, and the reference ground is inserted into Gnd.

3. The EEG fluctuation signal acquisition and analysis system according to claim 1, characterized in that: The neurotransmitter distribution diagram is represented by a bar graph, with different colors representing different states, and intuitively displaying normal values ​​and measured values.

4. The EEG fluctuation signal acquisition and analysis system according to claim 1, characterized in that: The brain function evaluation chart is used to show whether the brain is hypoxic, fatigued, excited, inhibited, and reversed.

5. The EEG fluctuation signal acquisition and analysis system according to claim 1, characterized in that: The EEG signal processing module is also used to determine the relationship between the six neurochemical transmitters and human biological characteristics, and to provide nutritional advice.

6. A brain fluctuation graph, characterized in that: The trolley comprises a base, an inclined support rod and a plurality of movable wheels, wherein the plurality of movable wheels are fixedly arranged on the lower surface of the base, the inclined support rod is fixedly arranged on the upper surface of the base, and the upper surface of the base is divided into a first area and a second area, wherein the area of ​​the first area is larger than that of the second area, the inclined support rod is located above the first area, and a chamber and a workbench are fixedly arranged in sequence from bottom to top, the second area is used for placing a host, and the workbench is used for placing a display, a keyboard and a mouse, an electroencephalogram signal acquisition device is movably arranged on the side of the workbench, and the host is integrated with the electroencephalogram fluctuation signal acquisition and analysis system described in any one of claims 1 to 5.

7. The brain fluctuation device according to claim 6, characterized in that: The workbench comprises a first workbench and a second workbench, wherein the first workbench and the second workbench are fixedly connected via a connecting column, the first workbench is used for placing a keyboard and a mouse, and the second workbench is used for placing a display.

8. The brain fluctuation device according to claim 7, characterized in that: It also includes a movable connecting piece, which includes a connecting piece, a first connecting rod and a second connecting rod. One end of the connecting piece is fixedly connected to the end of the connecting column, the side of the connecting piece is connected to one end of the first connecting rod, the other end of the first connecting rod is movably connected to one end of the second connecting rod, and the other end of the second connecting rod is fixedly connected to the EEG signal acquisition device.

9. The brain fluctuation device according to claim 6, characterized in that: A fixing device is disposed in the second area, and the host is detachably placed in the fixing device through the fixing device.

10. The brain fluctuation device according to claim 9, characterized in that: The fixing device includes a fixing plate and a binding belt, wherein a side edge of the fixing plate is fixedly arranged at an edge of the second area, one end of the binding belt is fixedly arranged at another side edge of the fixing plate, and the other end of the binding belt is fixedly arranged on the inclined support rod.

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