Biomarker detection device for biotechnology

Abstract

The invention relates to the technical field of biological detection, in particular to a biotechnology biomarker detection device which comprises a fixing seat, an annular sleeve is fixedly connected to the position, located at the bottom of the fixing seat, of the side surface of a middle through pipe, and a limiting shell is fixedly connected to the bottom of the annular sleeve. And a plurality of layers of fixed inner shells are movably connected into the limiting outer shell. According to the biomarker detection device for the biotechnology, it can be ensured that a proper amount of samples containing target biomarkers can be obtained, the samples have representativeness, detection result deviation caused by factors such as inaccurate sampling positions and improper sampling amount is reduced, detection data can more truly reflect the actual conditions of the biomarkers in organisms, and the detection accuracy is improved. A reliable basis is provided for disease diagnosis, treatment monitoring and the like, a tumor tissue sample is accurately taken in tumor marker detection, and the situation that the marker content detection result is low due to the fact that surrounding normal tissue is taken can be avoided, so that the accuracy of tumor diagnosis is improved.

Description

Technical Field

[0001] The present invention relates to the field of biological detection technology, in particular to a detection device for biomarkers used in biotechnology. Background Art

[0002] Biomarkers, also known as biomarkers or biological markers, refer to any substance, structure or process that can be objectively measured and evaluated and can reflect normal biological processes, pathological processes or responses to therapeutic interventions. Biomarker detection is the use of various technologies and methods to conduct qualitative or quantitative analysis of these biomarkers, thereby providing important basis for disease diagnosis, treatment, prognosis assessment, etc.

[0003] During the sampling process for biomarker detection, the distribution of different biomarkers in the body may vary. If the sampling site is inaccurate, samples containing enough target biomarkers may not be collected, resulting in inaccurate test results. When detecting tumor markers, if the tumor tissue is not accurately collected and the surrounding normal tissue is taken, the marker content test results may be low, affecting the judgment of the disease. At the same time, too little sampling may cause the detection device to be unable to obtain enough samples for analysis, or the accuracy and repeatability of the test results may be affected due to insufficient sample volume. Excessive sampling may cause sample waste, increase testing costs, and may also cause unnecessary harm or burden to the subjects being tested. Summary of the invention

[0004] The purpose of the present invention is to provide a detection device for biomarkers for biotechnology, so as to solve the problem that the distribution of different biomarkers in the body mentioned in the above background technology may be different. If the sampling site is inaccurate, it may not be possible to collect samples containing enough target biomarkers, resulting in inaccurate test results. When detecting tumor markers, if the tumor tissue is not accurately collected but the surrounding normal tissue is taken, the marker content test result may be low, affecting the judgment of the disease. At the same time, too little sampling may cause the detection device to be unable to obtain enough samples for analysis, or the accuracy and repeatability of the test results may be affected due to insufficient sample volume. Excessive sampling may cause sample waste, increase detection costs, and may also cause unnecessary harm or burden to the subject being tested. To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a detection device for biomarkers used in biotechnology, comprising a fixed seat, a cross slot is provided inside the fixed seat, a central tube is fixedly connected inside the cross slot, the side surface of the central tube is located at the bottom of the fixed seat and is fixedly connected to an annular sleeve, the bottom of the annular sleeve is fixedly connected to a limited outer shell, the interior of the limited outer shell is movably connected to a plurality of layers of fixed inner shells, the fixed inner shells are arranged in a circular shape inside the limited outer shell, a sampling tube is fixedly connected inside the fixed inner shell, the sampling tube is connected to the central tube, a marker sampling port is provided inside the sampling tube, and the fixed The top of the seat is movably connected with a fixed top plate, and a marker sampling port 2 is provided inside the fixed top plate. The marker sampling port 2 is communicated with the marker sampling port 1, so as to ensure that an appropriate amount of sample containing the target biomarker is obtained, and the sample is representative, thereby reducing the deviation of the test result caused by factors such as inaccurate sampling position and improper sampling amount, so that the test data can more truly reflect the actual situation of the biomarkers in the organism, and provide a reliable basis for disease diagnosis, treatment monitoring, etc. In tumor marker detection, accurate acquisition of tumor tissue samples can avoid low marker content test results due to sampling of surrounding normal tissues, thereby improving the accuracy of tumor diagnosis.

[0005] Further preferably, four support columns are fixedly connected to the bottom of the fixed seat, and the four support columns are symmetrically distributed at the bottom of the fixed seat. The bottoms of every two of the support columns are commonly fixedly connected to a connecting base plate, a limiting shell is fixedly connected between the two connecting base plates, and a limiting baffle is fixedly connected to the opposite sides of the two connecting base plates, and one side of the limiting baffle is fixedly connected to two support legs.

[0006] Further preferably, the two supporting legs are symmetrically distributed on one side of the limit baffle, and two sliding seats are fixedly connected to opposite sides of the two limit baffles, respectively, and the two sliding seats are symmetrically distributed.

[0007] Further preferably, a sliding groove is respectively opened inside each of the sliding seats, a sliding bar is movably connected inside the sliding groove, and two transmission frames are respectively fixedly connected to the opposite sides of the two limit baffles.

[0008] Further preferably, a transmission shaft is movably connected inside the transmission frame, a side surface of the transmission shaft is located on an internal transmission gear of the transmission frame, and a strap is fixedly connected to the top of the slide bar.

[0009] Further preferably, the strap is overlapped on the top of the fixed top plate, a through groove is provided inside the limit baffle, two grooves are provided inside the through groove, a return spring is fixedly connected inside each of the grooves, and a sliding block is movably connected inside the two grooves.

[0010] Further preferably, the top of the return spring is connected to the bottom of the sliding block, the top of the sliding block is fixedly connected with a connecting column, and the side surface of the connecting column is fixedly connected with a clearance transmission plate.

[0011] Further preferably, both sides of the fixed top plate are fixedly connected with hinged seats, and the hinged seats are movably connected to the air-avoiding transmission plate through hinges. Each sampling can be accurate and in place, ensuring the consistency in quantity and quality of samples from different batches, so that the test results have good repeatability. Whether it is the test at different time points of the same patient or the test comparison between different patients, it can more accurately reflect the changes in biomarkers, which is helpful for doctors to accurately judge and analyze the condition.

[0012] Compared with the prior art, the present invention has the following beneficial effects: In the present invention, it is possible to ensure that an appropriate amount of samples containing target biomarkers are obtained, and the samples are representative, reducing the deviation in test results caused by factors such as inaccurate sampling sites and improper sampling amounts, so that the test data can more truly reflect the actual situation of biomarkers in the body, and provide a reliable basis for disease diagnosis, treatment monitoring, etc. In tumor marker detection, accurate tumor tissue samples can be obtained to avoid low marker content test results due to the sampling of surrounding normal tissues, thereby improving the accuracy of tumor diagnosis.

[0013] In the present invention, each sampling can be accurate and in place, ensuring the consistency of quantity and quality of samples from different batches, so that the test results have good repeatability. Whether it is testing the same patient at different time points or comparing tests between different patients, it can more accurately reflect the changes in biomarkers, which helps doctors to accurately judge and analyze the condition. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 It is a schematic diagram of the three-dimensional main structure of the present invention; Figure 2 For the present invention Figure 1 The enlarged structural diagram at A in the middle; Figure 3 It is a top view of the three-dimensional structure of the present invention; Figure 4 For the present invention Figure 3 The enlarged structural diagram at B in the middle; Figure 5 It is a schematic diagram of the cross-sectional structure of the present invention; Figure 6 For the present invention Figure 5 Enlarged structural diagram at point C in the middle.

[0015] In the figure: 1. fixed seat; 2. cross slide; 3. middle tube; 4. annular sleeve; 5. limiting outer shell; 6. fixed inner shell; 7. sampling tube; 8. marker sampling port one; 9. fixed top plate; 901, marker sampling port two; 10. support column; 11. connecting bottom plate; 12. limiting baffle; 13. supporting leg; 14. sliding seat; 15. slide; 16. slide bar; 17. transmission frame; 18. transmission shaft; 19. transmission gear; 20. board; 21. through groove; 22. groove; 23. reset spring; 24. sliding block; 25. connecting column; 26. air-avoiding transmission plate; 27. hinged seat. DETAILED DESCRIPTION

[0016] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technical personnel in this field without creative work are within the scope of protection of the present invention.

[0017] See also Figure 1-Figure 6The present invention provides a technical solution: a detection device for biomarkers used in biotechnology, comprising a fixed seat 1, a cross slide 2 is provided inside the fixed seat 1, a middle tube 3 is fixedly connected inside the cross slide 2, the side surface of the middle tube 3 is located at the bottom of the fixed seat 1 and is fixedly connected with an annular sleeve 4, the bottom of the annular sleeve 4 is fixedly connected with a limited outer shell 5, the internal movably connected with a plurality of layers of fixed inner shells 6 inside the limited outer shell 5, the fixed inner shell 6 is arranged in a circular shape inside the limited outer shell 5, a sampling tube 7 is fixedly connected inside the fixed inner shell 6, the sampling tube 7 is connected with the middle tube 3, a marker sampling port 1 8 is provided inside the sampling tube 7, a fixed top plate 9 is movably connected with the top of the fixed seat 1, a marker sampling port 2 901 is provided inside the fixed top plate 9, and the marker sampling port 2 901 is connected with the marker sampling port 1 8 , fixed and limited by the support legs 13, and limited at the outside where sampling is required by the limiting outer shell 5. At the same time, when sampling, the position of the sampling tube 7 is adjusted by adjusting the fixed inner shell 6 of the multi-layer structure to perform accurate sampling. The sampling device is sampled through the marker sampling port 2 901 and the marker sampling port 1 8, which can ensure that an appropriate amount of sample containing the target biomarker is obtained, and the sample is representative, reducing the deviation of the test result caused by factors such as inaccurate sampling position and improper sampling amount, so that the test data can more truly reflect the actual situation of the biomarker in the organism, and provide a reliable basis for disease diagnosis, treatment monitoring, etc. In tumor marker detection, accurate tumor tissue samples can be obtained, which can avoid the low marker content test result due to the sampling of surrounding normal tissues, thereby improving the accuracy of tumor diagnosis.

[0018] In this embodiment, Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 and Figure 6 As shown, four support columns 10 are fixedly connected to the bottom of the fixed seat 1, and the four support columns 10 are symmetrically distributed at the bottom of the fixed seat 1, and a connecting base plate 11 is fixedly connected to the bottom of every two support columns 10, and a limiting housing 5 is fixedly connected between the two connecting base plates 11, and a limiting baffle 12 is fixedly connected to one side of the limiting baffle 12. Two supporting legs 13 are fixedly connected to one side of the limiting baffle 12, and the two supporting legs 13 are symmetrically distributed on one side of the limiting baffle 12, and two sliding seats 14 are fixedly connected to the opposite sides of the two limiting baffles 12. The two sliding seats 14 are symmetrically distributed, and a sliding groove 15 is respectively opened inside each sliding seat 14, and a sliding bar 16 is movably connected inside the sliding groove 15, and two transmission frames 17 are fixedly connected to the opposite sides of the two limiting baffles 12, and a transmission shaft 18 is movably connected inside the transmission frame 17. The side surface of the transmission shaft 18 is located at the internal transmission gear 19 of the transmission frame 17, and a strap 20 is fixedly connected to the top of the sliding bar 16.

[0019] In this embodiment, Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 and Figure 6 As shown, the strap 20 is overlapped on the top of the fixed top plate 9, the limiting baffle 12 is provided with a through groove 21 inside, and two grooves 22 are provided inside the through groove 21, and a return spring 23 is fixedly connected inside each groove 22, and a sliding block 24 is movably connected inside the two grooves 22, and the top of the return spring 23 is connected to the bottom of the sliding block 24, and the top of the sliding block 24 is fixedly connected with a connecting column 25, and the side surface of the connecting column 25 is fixedly connected with an air-avoiding transmission plate 26, and the two sides of the fixed top plate 9 are fixedly connected with hinged seats 27, and the hinged seats 27 are movably connected to the air-avoiding transmission plate 26 through hinges. During the sampling process, it is necessary to gradually press down and infiltrate into the biological material to be sampled little by little, through The external motor drives the transmission shaft 18 to rotate. When the transmission shaft 18 rotates, it drives the transmission gear 19 to rotate, thereby driving the slide bar 16 to pull downward, and then driving the fixed top plate 9 to move downward, wherein an electromagnet is provided at the bottom of the fixed top plate 9, and the middle tube 3 is made of iron material, and then when the fixed top plate 9 moves downward, the middle tube 3 gradually moves downward, so as to take samples. Each sampling can be accurate and in place, ensuring the consistency of quantity and quality of samples from different batches, so that the test results have good repeatability. Whether it is the detection of the same patient at different time points or the detection comparison between different patients, it can more accurately reflect the changes in biomarkers, which is helpful for doctors to accurately judge and analyze the condition.

[0020] The use method and advantages of the present invention: When the biotechnology biomarker detection device is used, the working process is as follows: like Figure 1 , Figure 2 , Figure 3 , Figure 4 , Figure 5 and Figure 6As shown, when the biomarker detection device is used for biological sampling, the support leg 13 is used for fixed limiting, and the limiting outer shell 5 is used for limiting at the outside where sampling is required. At the same time, when sampling, the position of the sampling tube 7 is adjusted by adjusting the fixed inner shell 6 of the multi-layer structure to perform accurate sampling. The sampling device is used for sampling through the marker sampling port 2 901 and the marker sampling port 1 8, which can ensure that an appropriate amount of sample containing the target biomarker is obtained, and the sample is representative, reducing the deviation of the test result caused by factors such as inaccurate sampling position and improper sampling amount, so that the test data can more truly reflect the actual situation of the biomarker in the organism, and provide a reliable basis for disease diagnosis, treatment monitoring, etc. In tumor marker detection, accurate tumor tissue samples can be obtained to avoid the low marker content test result due to the sampling of surrounding normal tissues. , thereby improving the accuracy of tumor diagnosis. During the sampling process, it is necessary to gradually press down and penetrate into the biological material to be sampled little by little. The transmission shaft 18 is driven to rotate by an external motor. When the transmission shaft 18 rotates, it drives the transmission gear 19 to rotate, thereby driving the slide bar 16 to pull down, and then driving the fixed top plate 9 to move downward, wherein the bottom of the fixed top plate 9 is provided with an electromagnet, and the middle tube 3 is made of iron material, and then when the fixed top plate 9 moves downward, the middle tube 3 gradually moves downward, thereby sampling. Each sampling can be accurate and in place, ensuring the consistency of different batches of samples in quantity and quality, so that the test results have good repeatability. Whether it is the detection of the same patient at different time points or the detection comparison between different patients, it can more accurately reflect the changes in biomarkers, which is helpful for doctors to accurately judge and analyze the condition.

[0021] The above shows and describes the basic principles, main features and advantages of the present invention. Technical personnel in this industry should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only preferred examples of the present invention and are not used to limit the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. A biomarker detection device for biotechnology, comprising a fixing seat (1), characterized in that: A cross groove (2) is provided inside the fixed seat (1), a central tube (3) is fixedly connected inside the cross groove (2), a side surface of the central tube (3) is fixedly connected to an annular sleeve (4) located at the bottom of the fixed seat (1), the bottom of the annular sleeve (4) is fixedly connected to a limiting outer shell (5), a plurality of fixed inner shells (6) are movably connected inside the limiting outer shell (5), the fixed inner shells (6) are arranged in a circular shape inside the limiting outer shell (5), a sampling tube (7) is fixedly connected inside the fixed inner shell (6), the sampling tube (7) is connected to the central tube (3), a marker sampling port 1 (8) is provided inside the sampling tube (7), a fixed top plate (9) is movably connected to the top of the fixed seat (1), a marker sampling port 2 (901) is provided inside the fixed top plate (9), and the marker sampling port 2 (901) is connected to the marker sampling port 1 (8).

2. A biomarker detection device for biotechnology according to claim 1, characterized in that: Four support columns (10) are fixedly connected to the bottom of the fixing seat (1), and the four support columns (10) are symmetrically distributed at the bottom of the fixing seat (1). A connecting base plate (11) is fixedly connected to the bottoms of every two of the support columns (10), a limiting housing (5) is fixedly connected between the two connecting base plates (11), and a limiting baffle (12) is fixedly connected to the opposite sides of the two connecting base plates (11), and one side of the limiting baffle (12) is fixedly connected to two support legs (13).

3. A biomarker detection device for biotechnology according to claim 2, characterized in that: The two support legs (13) are symmetrically distributed on one side of the limit baffle (12); two sliding seats (14) are respectively fixedly connected to opposite sides of the two limit baffles (12); and the two sliding seats (14) are symmetrically distributed.

4. A biomarker detection device for biotechnology according to claim 3, characterized in that: Each of the sliding seats (14) is provided with a sliding groove (15) inside, and a sliding bar (16) is movably connected inside the sliding groove (15). Two transmission frames (17) are fixedly connected to opposite sides of the two limit baffles (12).

5. A biomarker detection device for biotechnology according to claim 4, characterized in that: The transmission frame (17) is movably connected to a transmission shaft (18) inside, the side surface of the transmission shaft (18) is located on an internal transmission gear (19) of the transmission frame (17), and the top of the slide bar (16) is fixedly connected to a strap (20).

6. A biomarker detection device for biotechnology according to claim 5, characterized in that: The strap (20) is overlapped on the top of the fixed top plate (9), the limit baffle (12) is provided with a through groove (21) inside, the through groove (21) is provided with two grooves (22) inside, each groove (22) is fixedly connected with a return spring (23) inside, and the two grooves (22) are movably connected with a sliding block (24) inside.

7. The biomarker detection device for biotechnology according to claim 5, characterized in that: The top of the return spring (23) is connected to the bottom of the sliding block (24), the top of the sliding block (24) is fixedly connected to a connecting column (25), and the side surface of the connecting column (25) is fixedly connected to a clearance transmission plate (26).

8. The biomarker detection device for biotechnology according to claim 5, characterized in that: The fixed top plate (9) has hinge seats (27) fixedly connected to both sides thereof, and the hinge seats (27) are movably connected to the air-avoiding transmission plate (26) via hinges.

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