A formulation system and preparation method for improving solubility and stability of ceramide NP

Abstract

The application provides a formula system and a preparation method for improving the solubility and stability of ceramide NP, and belongs to the cosmetic field.The formula system comprises: an active ingredient, an emulsifier, a thickening agent and a solvent; the active ingredient is ceramide NP; the emulsifier comprises at least one of an anionic emulsifier, a natural polymer emulsifier, a non-ionic emulsifier and a phospholipid emulsifier; and the solvent comprises water, a polyhydric alcohol and an oil-soluble solvent.The formula system has an unexpected technical effect of greatly improving the stability of an oil-in-water cosmetic containing more ceramide NP by selecting suitable emulsifiers, thickening agents and solvents.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of cosmetics, in particular to a formula system for improving solubility and stability of ceramide NP and a preparation method. BACKGROUND

[0002] Ceramides are a natural lipid that is present in the skin. Ceramides form a water-repellent barrier on the skin surface. Newborn babies often have a waxy substance on their skin, called vernix, which is mainly composed of ceramides and can prevent water loss from the skin. The secretion of ceramides in the skin decreases with age, which leads to dry skin, wrinkles, and some skin inflammation.

[0003] Ceramide NP is a class of compounds composed of sphingosine base chain and amide fatty acid, which has long-chain fatty acid in its structure. Because of its structural characteristics, it is difficult to make an oil-in-water emulsion system containing a high content of ceramide NP stable, and it is difficult to pass high and low temperature stability, which may cause separation or chromatography.

[0004] In addition, ceramide NP has poor stability under high temperature and light conditions and is prone to degradation. Therefore, how to improve the stability of ceramide NP in the product is still a difficult problem to be solved.

[0005] Therefore, there is still an urgent need for a ceramide NP composition that is easy to emulsify, simple to operate, and has good stability of the emulsion system. SUMMARY

[0006] To solve the above technical problems, the present application provides the following technical solutions.

[0007] In a first aspect, the present application provides a ceramide NP-containing composition.

[0008] A composition comprising: an active ingredient, an emulsifier, a thickening agent, and a solvent;

[0009] The active ingredient is ceramide NP;

[0010] The emulsifier comprises at least one of an anionic emulsifier, a natural polymer emulsifier, a non-ionic emulsifier, and a phospholipid emulsifier;

[0011] The solvent comprises water, a polyol, and an oil-soluble solvent.

[0012] In some embodiments, the thickening agent is propylene glycol alginate.

[0013] In some embodiments, the anionic emulsifier is sodium stearoyl glutamate.

[0014] In some embodiments, the natural high molecular emulsifier is inulin lauryl carbamate.

[0015] In some embodiments, the non-ionic emulsifier is polyglyceryl-10 stearate.

[0016] In some embodiments, the phospholipid emulsifier is lecithin.

[0017] In some embodiments, the polyol includes at least one of butylene glycol, propylene glycol, dipropylene glycol. In some preferred embodiments, the polyol is 1,3-butylene glycol, which is more advantageous to improve the appearance, viscosity, and stability of the ceramide NP content of the resulting composition under high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high-low temperature cycle, and the like.

[0018] In some embodiments, the oil-soluble solvent includes at least one of alkyl alcohol solvent, glyceryl tri(ethylhexanoate), caprylic / capric triglyceride, isononyl isononanoate, and the like. In some embodiments, the oil-soluble solvent is preferably alkyl alcohol solvent, which is advantageous to improve the appearance, viscosity, and stability of the ceramide NP content of the resulting composition under high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high-low temperature cycle, and the like. In some embodiments, the oil-soluble solvent is more preferably octyldodecanol, which is more advantageous to improve the appearance, viscosity, and stability of the ceramide NP content of the resulting composition under high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high-low temperature cycle, and the like.

[0019] In some embodiments, the solvent is preferably water, 1,3-butylene glycol, and octyldodecanol, which is advantageous to improve the appearance, viscosity, and stability of the ceramide NP content of the resulting composition under high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high-low temperature cycle, and the like.

[0020] In some embodiments, the content of the ceramide NP is 0.010 wt%-2.000 wt%, based on the total mass of the composition. In some embodiments, the content of the ceramide NP is 0.010 wt%, 0.050 wt%, 0.100 wt%, 0.500 wt%, 1.000 wt%, 1.500 wt%, or 2.000 wt%, based on the total mass of the composition.

[0021] In some embodiments, the content of the anionic emulsifier is 0.010 wt% - 0.400 wt%, calculated based on the total mass of the composition. In some embodiments, the content of the anionic emulsifier is 0.010 wt%, 0.100 wt%, 0.200 wt%, 0.300 wt%, or 0.400 wt%, calculated based on the total mass of the composition.

[0022] In some embodiments, the content of the natural high molecular emulsifier is 0.050 wt% - 1.000 wt%, calculated based on the total mass of the composition. In some embodiments, the content of the natural high molecular emulsifier is 0.050 wt%, 0.100 wt%, 0.150 wt%, 0.200 wt%, 0.250 wt%, 0.300 wt%, 0.350 wt%, or 1.000 wt%, calculated based on the total mass of the composition.

[0023] In some embodiments, the content of the non-ionic emulsifier is 0.100 wt% - 3.000 wt%, calculated based on the total mass of the composition. In some embodiments, the content of the non-ionic emulsifier is 0.100 wt%, 0.200 wt%, 0.300 wt%, 0.400 wt%, 0.500 wt%, 1.000 wt%, 1.500 wt%, 2.000 wt%, 2.500 wt%, or 3.000 wt%, calculated based on the total mass of the composition. In some embodiments, the content of the non-ionic emulsifier is 0.100 wt% - 0.400 wt%, calculated based on the total mass of the composition.

[0024] In some embodiments, the content of the phospholipid emulsifier is 0.010 wt% - 0.600 wt%, calculated based on the total mass of the composition. In some embodiments, the content of the phospholipid emulsifier is 0.010 wt%, 0.050 wt%, 0.100 wt%, 0.150 wt%, 0.200 wt%, 0.300 wt%, 0.400 wt%, 0.500 wt%, or 0.600 wt%, calculated based on the total mass of the composition.

[0025] In some embodiments, the thickening agent is present in an amount of 0.0002 wt% to 0.500 wt%, based on the total mass of the composition. In some embodiments, the thickening agent is present in an amount of 0.0002 wt%, 0.0010 wt%, 0.0050 wt%, 0.010 wt%, 0.020 wt%, 0.030 wt%, 0.040 wt%, 0.100 wt%, 0.200 wt%, 0.300 wt%, 0.400 wt%, or 0.500 wt%, based on the total mass of the composition.

[0026] In some embodiments, the polyol is present in an amount of 2.000 wt% to 12.000 wt%, based on the total mass of the composition. In some embodiments, the polyol is present in an amount of 2.000 wt%, 3.000 wt%, 3.500 wt%, 4.000 wt%, 5.000 wt%, 6.000 wt%, 7.000 wt%, 8.000 wt%, 9.000 wt%, 10.000 wt%, 11.000 wt%, or 12.000 wt%, based on the total mass of the composition.

[0027] In some embodiments, the oil-soluble solvent is an alkyl alcohol solvent, and the alkyl alcohol solvent is present in an amount of 0.200 wt% to 7.000 wt%, based on the total mass of the composition. In some embodiments, the oil-soluble solvent is an alkyl alcohol solvent, and the alkyl alcohol solvent is present in an amount of 0.200 wt%, 0.500 wt%, 1.000 wt%, 2.000 wt%, 3.000 wt%, 4.000 wt%, 5.000 wt%, 6.000 wt%, or 7.000 wt%, based on the total mass of the composition.

[0028] In some embodiments, the ceramide NP is present in an amount of 0.010 wt% to 2.000 wt%, the anionic emulsifier is present in an amount of 0.010 wt% to 0.400 wt%, the natural high molecular emulsifier is present in an amount of 0.050 wt% to 1.000 wt%, the nonionic emulsifier is present in an amount of 0.100 wt% to 3.000 wt%, the phospholipid emulsifier is present in an amount of 0.010 wt% to 0.600 wt%, the thickening agent is present in an amount of 0.0002 wt% to 0.500 wt%, the polyol is present in an amount of 2.000 wt% to 5.000 wt%, the oil-soluble solvent is an alkyl alcohol solvent, and the alkyl alcohol solvent is present in an amount of 0.200 wt% to 7.000 wt%, with the balance being water, based on the total mass of the composition.

[0029] In some embodiments, the content of the ceramide NP is 0.010 wt%, the content of the anionic emulsifier is 0.010 wt%, the content of the nonionic emulsifier is 0.100 wt%, the content of the natural high molecular emulsifier is 0.050 wt%, the content of the phospholipid emulsifier is 0.010 wt%, the content of the thickening agent is 0.0002 wt%, the content of the polyol is 3.500 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 0.200 wt%, and the balance is water, based on the total mass of the composition.

[0030] In some embodiments, the content of the ceramide NP is 2.000 wt%, the content of the anionic emulsifier is 0.400 wt%, the content of the nonionic emulsifier is 3.000 wt%, the content of the natural high molecular emulsifier is 1.000 wt%, the content of the phospholipid emulsifier is 0.600 wt%, the content of the thickening agent is 0.500 wt%, the content of the polyol is 3.500 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 7.000 wt%, and the balance is water, based on the total mass of the composition.

[0031] In some embodiments, the content of the ceramide NP is 1.000 wt%, the content of the anionic emulsifier is 0.300 wt%, the content of the nonionic emulsifier is 1.000 wt%, the content of the natural high molecular emulsifier is 0.500 wt%, the content of the phospholipid emulsifier is 0.200 wt%, the content of the thickening agent is 0.300 wt%, the content of the polyol is 3.500 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000 wt%, and the balance is water, based on the total mass of the composition.

[0032] In some embodiments, the content of the ceramide NP is 1.000 wt%, the content of the anionic emulsifier is 0.300 wt%, the content of the nonionic emulsifier is 1.000 wt%, the content of the natural high molecular emulsifier is 0.200 wt%, the content of the phospholipid emulsifier is 0.200 wt%, the content of the thickening agent is 0.300 wt%, the content of the polyol is 3.500 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000 wt%, and the balance is water, based on the total mass of the composition.

[0033] In some embodiments, the thickening agent is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural high molecular emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglyceryl-10 stearate; the phospholipid emulsifier is lecithin; the solvent comprises water, a polyol, and an oil-soluble solvent; the polyol is 1,3-butanediol; and the oil-soluble solvent is octyldodecanol.

[0034] In some embodiments, the thickening agent is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural high molecular emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglyceryl-10 stearate; the phospholipid emulsifier is lecithin; the solvent comprises water, a polyol, and an oil-soluble solvent; the polyol is 1,3-butanediol; the oil-soluble solvent is octyldodecanol; the content of the ceramide NP is 0.010 wt% to 2.000 wt%, the content of the anionic emulsifier is 0.010 wt% to 0.400 wt%, the content of the natural high molecular emulsifier is 0.050 wt% to 1.000 wt%, the content of the nonionic emulsifier is 0.100 wt% to 3.000 wt%, the content of the phospholipid emulsifier is 0.010 wt% to 0.600 wt%, the content of the thickening agent is 0.0002 wt% to 0.500 wt%, the content of the polyol is 2.000 wt% to 5.000 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 0.200 wt% to 7.000 wt%, and the balance is water, based on the total mass of the composition.

[0035] In some embodiments, the thickening agent is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural high molecular emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglyceryl-10 stearate; the phospholipid emulsifier is lecithin; the solvent comprises water, a polyol, and an oil-soluble solvent; the polyol is 1,3-butanediol; the oil-soluble solvent is octyldodecanol; the content of the ceramide NP is 0.010 wt%, the content of the anionic emulsifier is 0.010 wt%, the content of the nonionic emulsifier is 0.100 wt%, the content of the natural high molecular emulsifier is 0.050 wt%, the content of the phospholipid emulsifier is 0.010 wt%, the content of the thickening agent is 0.0002 wt%, the content of the polyol is 3.500 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 0.200 wt%, and the balance is water, based on the total mass of the composition.

[0036] In some embodiments, the thickening agent is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural high molecular emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglyceryl-10 stearate; the phospholipid emulsifier is lecithin; the solvent includes water, a polyol, and an oil-soluble solvent; the polyol is 1,3-butanediol; the oil-soluble solvent is octyldodecanol; the content of the ceramide NP is 2.000wt%, the content of the anionic emulsifier is 0.400wt%, the content of the nonionic emulsifier is 3.000wt%, the content of the natural high molecular emulsifier is 1.000wt%, the content of the phospholipid emulsifier is 0.600wt%, the content of the thickening agent is 0.500wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 7.000wt%, and the balance is water, based on the total mass of the composition.

[0037] In some embodiments, the thickening agent is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural high molecular emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglyceryl-10 stearate; the phospholipid emulsifier is lecithin; the solvent includes water, a polyol, and an oil-soluble solvent; the polyol is 1,3-butanediol; the oil-soluble solvent is octyldodecanol; the content of the ceramide NP is 1.000wt%, the content of the anionic emulsifier is 0.300wt%, the content of the nonionic emulsifier is 1.000wt%, the content of the natural high molecular emulsifier is 0.500wt%, the content of the phospholipid emulsifier is 0.200wt%, the content of the thickening agent is 0.300wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000wt%, and the balance is water, based on the total mass of the composition.

[0038] In some embodiments, the thickening agent is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural high molecular emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglyceryl-10 stearate; the phospholipid emulsifier is lecithin; the solvent comprises water, a polyol, and an oil-soluble solvent; the polyol is 1,3-butanediol; the oil-soluble solvent is octyldodecanol; the content of the ceramide NP is 1.000 wt%, the content of the anionic emulsifier is 0.300 wt%, the content of the nonionic emulsifier is 1.000 wt%, the content of the natural high molecular emulsifier is 0.200 wt%, the content of the phospholipid emulsifier is 0.200 wt%, the content of the thickening agent is 0.300 wt%, the content of the polyol is 3.500 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000 wt%, and the balance is water, based on the total mass of the composition.

[0039] In some embodiments, the thickening agent is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural high molecular emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglyceryl-10 stearate; the phospholipid emulsifier is lecithin; the solvent comprises water, a polyol, and an oil-soluble solvent; the polyol is 1,3-butanediol; the oil-soluble solvent comprises an alkyl alcohol solvent.

[0040] In some embodiments, the thickening agent is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural high molecular emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglyceryl-10 stearate; the phospholipid emulsifier is lecithin; the solvent comprises water, a polyol, and an oil-soluble solvent; the polyol is 1,3-butanediol; the oil-soluble solvent comprises an alkyl alcohol solvent; the content of the ceramide NP is 0.010 wt% - 2.000 wt%, the content of the anionic emulsifier is 0.010 wt% - 0.400 wt%, the content of the natural high molecular emulsifier is 0.050 wt% - 1.000 wt%, the content of the nonionic emulsifier is 0.100 wt% - 3.000 wt%, the content of the phospholipid emulsifier is 0.010 wt% - 0.600 wt%, the content of the thickening agent is 0.0002 wt% - 0.500 wt%, the content of the polyol is 2.000 wt% - 5.000 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 0.200 wt% - 7.000 wt%, and the balance is water, based on the total mass of the composition.

[0041] In some embodiments, the thickening agent is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural high molecular emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglyceryl-10 stearate; the phospholipid emulsifier is lecithin; the solvent includes water, a polyol, and an oil-soluble solvent; the polyol is 1,3-butanediol; the oil-soluble solvent includes an alkyl alcohol solvent; the content of the ceramide NP is 0.010 wt%, the content of the anionic emulsifier is 0.010 wt%, the content of the nonionic emulsifier is 0.100 wt%, the content of the natural high molecular emulsifier is 0.050 wt%, the content of the phospholipid emulsifier is 0.010 wt%, the content of the thickening agent is 0.0002 wt%, the content of the polyol is 3.500 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 0.200 wt%, and the balance is water, based on the total mass of the composition.

[0042] In some embodiments, the thickening agent is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural high molecular emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglyceryl-10 stearate; the phospholipid emulsifier is lecithin; the solvent includes water, a polyol, and an oil-soluble solvent; the polyol is 1,3-butanediol; the oil-soluble solvent includes an alkyl alcohol solvent; the content of the ceramide NP is 2.000 wt%, the content of the anionic emulsifier is 0.400 wt%, the content of the nonionic emulsifier is 3.000 wt%, the content of the natural high molecular emulsifier is 1.000 wt%, the content of the phospholipid emulsifier is 0.600 wt%, the content of the thickening agent is 0.500 wt%, the content of the polyol is 3.500 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 7.000 wt%, and the balance is water, based on the total mass of the composition.

[0043] In some embodiments, the thickening agent is propylene glycol alginate; the anionic emulsifier is sodium stearoyl glutamate; the natural high molecular emulsifier is inulin lauryl carbamate; the nonionic emulsifier is polyglyceryl-10 stearate; the phospholipid emulsifier is lecithin; the solvent comprises water, a polyol, and an oil-soluble solvent; the polyol is 1,3-butanediol; the oil-soluble solvent comprises an alkyl alcohol solvent; the content of the ceramide NP is 1.000 wt%, the content of the anionic emulsifier is 0.300 wt%, the content of the nonionic emulsifier is 1.000 wt%, the content of the natural high molecular emulsifier is 0.500 wt%, the content of the phospholipid emulsifier is 0.200 wt%, the content of the thickening agent is 0.300 wt%, the content of the polyol is 3.500 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000 wt%, and the balance is water, based on the total mass of the composition.

[0044] In some embodiments, the content of the ceramide NP is 1.000 wt%, the content of the anionic emulsifier is 0.300 wt%, the content of the nonionic emulsifier is 1.000 wt%, the content of the natural high molecular emulsifier is 0.200 wt%, the content of the phospholipid emulsifier is 0.200 wt%, the content of the thickening agent is 0.300 wt%, the content of the polyol is 3.500 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000 wt%, and the balance is water, based on the total mass of the composition.

[0045] In a second aspect, the present application provides a method for preparing the composition of the first aspect.

[0046] A method for preparing the composition of the first aspect, characterized in that it comprises the following steps:

[0047] Step (1): mixing and dispersing the components in component 2 to obtain a component 2 mixture; then mixing and heating the components in component 1 to obtain a component 1 mixture, adding the component 2 mixture to the component 1 mixture, homogenizing, defoaming, and obtaining a mixture A; the component 1 comprises water, an anionic emulsifier, a phospholipid emulsifier, a natural high molecular emulsifier, and part of the formula amount of a polyol; the component 2 comprises a thickening agent and the remaining formula amount of a polyol;

[0048] Step (2): heating and dissolving component 3 to obtain a mixture B; the component 3 comprises a nonionic emulsifier, an active ingredient, and an oil-soluble solvent;

[0049] Step (3): mixing mixture A and mixture B, homogenizing, defoaming, and obtaining the composition.

[0050] In some embodiments, the partial recipe amount of polyol in step (1) is three- seventh to five-sevenths recipe amount of polyol. In some embodiments, the partial recipe amount of polyol in step (1) is four-sevenths recipe amount of polyol.

[0051] In some embodiments, the temperature of heated component 1 in step (1) is 80-90 °C. In some embodiments, the temperature of heated component 1 in step (1) is 80 °C, 85 °C, or 90 °C.

[0052] In some embodiments, the homogenization speed of homogenization in step (1) is 2500-3500 rpm. In some embodiments, the homogenization speed of homogenization in step (1) is 2500 rpm, 3000 rpm, or 3500 rpm.

[0053] In some embodiments, the time of homogenization in step (1) is 2-6 minutes. In some embodiments, the time of homogenization in step (1) is 2 minutes, 3 minutes, 4 minutes, 5 minutes, or 6 minutes.

[0054] In some embodiments, the defoaming in step (1) is vacuum defoaming.

[0055] In some embodiments, the temperature of heated dissolution in step (2) is 80-95 °C. In some embodiments, the temperature of heated dissolution in step (2) is 80 °C, 85 °C, 90 °C, or 95 °C.

[0056] In some embodiments, the homogenization speed of homogenization in step (3) is 2500-3500 rpm. In some embodiments, the homogenization speed of homogenization in step (3) is 2500 rpm, 3000 rpm, or 3500 rpm.

[0057] In some embodiments, the time of homogenization in step (3) is 2-8 minutes. In some embodiments, the time of homogenization in step (3) is 2 minutes, 3 minutes, 4 minutes, 5 minutes, 6 minutes, 7 minutes, or 8 minutes.

[0058] In some embodiments, the defoaming in step (3) is vacuum defoaming.

[0059] In a third aspect, the present application provides use of the composition of the first aspect or the composition prepared by the method of the second aspect.

[0060] Use of the composition of the first aspect or the composition prepared by the method of the second aspect in the preparation of a cosmetic.

[0061] Beneficial effects

[0062] Compared with the prior art, the technical scheme provided by the present application has at least one of the following beneficial technical effects:

[0063] (1) Compared with the formula lacking any one of the natural high molecular emulsifier, phospholipid emulsifier and anionic emulsifier, the formula obtained by simultaneously using the natural high molecular emulsifier, phospholipid emulsifier and anionic emulsifier as the emulsifier has more excellent appearance and appearance, viscosity and stability of ceramide NP content under high temperature, refrigeration (0℃), freezing (-15℃), room temperature, light, high-low temperature cycle and the like, which shows that the natural high molecular emulsifier, phospholipid emulsifier and anionic emulsifier provided by the present application play a synergistic role.

[0064] (2) Compared with using other oil-soluble solvents (such as caprylic / capric triglyceride), using the alkyl alcohol solvent (such as octyldodecanol) provided by the present application is more conducive to improving the appearance and appearance, viscosity and stability of ceramide NP content under high temperature, refrigeration (0℃), freezing (-15℃), room temperature, light, high-low temperature cycle and the like of the obtained ceramide NP composition, which has unexpected technical effects.

[0065] (3) Compared with other natural high molecular emulsifiers (such as glyceryl stearate citrate, cocoglycoside or arachin glycoside), using the natural high molecular emulsifier (such as inulin lauryl carbamate) provided by the present application is more conducive to improving the appearance and appearance, viscosity and stability of ceramide NP content under high temperature, refrigeration (0℃), freezing (-15℃), room temperature, light, high-low temperature cycle and the like of the obtained ceramide NP composition, which has unexpected technical effects.

[0066] (4) Compared with other phospholipid emulsifiers (such as hydrogenated lysolecithin, hydrogenated lecithin or hydroxylated lecithin), using the lecithin provided by the present application is more conducive to improving the appearance and appearance, viscosity and stability of ceramide NP content under high temperature, refrigeration (0℃), freezing (-15℃), room temperature, light, high-low temperature cycle and the like of the obtained ceramide NP composition, which has unexpected technical effects.

[0067] (5) Compared with other thickening agents (such as caesalpinia spinosa gum, xanthan gum or hydrogenated xanthan gum), using the propylene glycol alginate provided by the present application as a thickening agent is more conducive to improving the appearance and appearance, viscosity and stability of ceramide NP content under high temperature, refrigeration (0℃), freezing (-15℃), room temperature, light, high-low temperature cycle and the like of the obtained ceramide NP composition, which has unexpected technical effects.

[0068] (7) The ceramide NP composition provided by the application has good appearance shape, good appearance shape, viscosity and ceramide NP content stability, and has excellent technical effects.

[0069] Terminology

[0070] In the foregoing of the present application, all the numbers disclosed herein are approximations. Based on the numbers disclosed, each number can be varied by ±10% or a reasonable range in the art, such as ±1%, ±2%, ±3%, ±4%, or ±5%.

[0071] The term "room temperature" means ambient temperature, which refers to a temperature of about 15°C to about 35°C, or about 20°C to 30°C, or about 25°C.

[0072] The term "optional", "optionally", or "optional" means that the event or circumstance subsequently described can or can not occur.

[0073] The term "and / or" should be understood to mean either one of the items or a combination of any two or more of the items.

[0074] The term "wt%" means mass percentage.

[0075] In the description of the present application, the description of the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in connection with the embodiment or example are included in at least one embodiment or example of the present application. In the present specification, the illustrative description of the above terms is not necessarily directed to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any appropriate manner in any one or more embodiments or examples. In addition, the skilled person in the art can combine and combine the different embodiments or examples described in the present specification and the features of the different embodiments or examples without contradiction.

[0076] The structure of the "ceramide NP" described in the present application is:

[0077]

[0078] The term "light source D65", also known as International Standard Artificial Daylight, has a color temperature of 6500K, and its spectrum is similar to natural daylight.

[0079] The term "TL84 light source" belongs to a three-primary-color fluorescent light source, and has a color temperature of 4000K. DETAILED DESCRIPTION

[0080] In order for those skilled in the art to better understand the technical solutions of the present application, some non-limiting embodiments are further disclosed below to further illustrate the present application.

[0081] The reagents used in the present application can be purchased from the market or can be prepared by the methods described in the present application.

[0082] The detection method of ceramide NP content can refer to the following literature or other existing technology methods for detection: Zhao G, Su W, Wang F. Determination of ceramide NP and AP content in liposomes by high performance liquid chromatography-evaporative light scattering method [J]. China Daily Chemical Industry (English), 2023, 53(12): 1466-1471.

[0083] Examples 1-4: Preparation of ceramide NP composition

[0084] Formulation: see Table 1.

[0085] Table 1: Formulation of ceramide NP composition

[0086]

[0087] Preparation method:

[0088] Step (1): mix and disperse each component in component 2 to obtain component 2 mixture; then mix each component in component 1 and heat to 80°C to obtain component 1 mixture, add component 2 mixture to component 1 mixture, homogenize (homogenization speed 2000 rpm (may be 2000 rpm-3000 rpm), time 2 minutes (may be 2 minutes-6 minutes)), defoam, to obtain mixture A;

[0089] Step (2): mix each component in component 3, heat to 80°C (may be 80-90°C) to dissolve, to obtain mixture B;

[0090] Step (3): mix mixture A and mixture B, homogenize (homogenization speed 2500 rpm (may be 2500 rpm-3500 rpm), time 3 minutes (may be 2 minutes-8 minutes)), defoam, cool to room temperature, to obtain the composition.

[0091] Comparative Examples 1-5: Ceramide NP composition missing a single component

[0092] Formulation: see Table 2.

[0093] Table 2: Ceramide NP composition missing a single component

[0094]

[0095] Preparation method: prepared according to the method of Reference Example 3 (components with a formulation content of 0 correspond to no addition).

[0096] Test Example 1: Stability investigation

[0097] Formulation: see Table 3.

[0098] Table 3:

[0099]

[0100] Preparation method: prepared according to the method of Reference Example 3.

[0101] Test Examples 1 to 3: Investigation of natural polymer emulsifiers

[0102] Formulation: see Table 4.

[0103] Table 4: Investigation formulation of natural polymer emulsifiers

[0104]

[0105] Preparation method: prepared according to the method of Reference Example 3.

[0106] Test Examples 4 to 6: Investigation of phospholipid emulsifiers

[0107] Formulation: see Table 5.

[0108] Table 5: Investigation formulation of phospholipid emulsifiers

[0109]

[0110] Preparation method: prepared according to the method of Reference Example 3.

[0111] Test Examples 7 to 9: Investigation of thickeners

[0112] Formulation: see Table 6.

[0113] Table 6: Investigation formulation of thickeners

[0114]

[0115] Preparation method: prepared according to the method of Reference Example 3.

[0116] Test Example 1: Stability investigation

[0117] Take 30 mL of each composition obtained in each of the above examples and comparative examples, respectively, and place them in 50℃, 0℃, light, room temperature (25℃), high-low temperature cycle conditions, respectively, to test the product stability (appearance, viscosity, ceramide NP content (ceramide NP content represents the percentage value of the measured concentration to the theoretical concentration before content detection, and first mix uniformly)).

[0118] Light test: place the sample to be tested in a light box to receive light source irradiation (D65 light source: simulate sunlight, 10000 lux; TL84 light source: simulate counter light source, 500 lux).

[0119] High-low temperature cycle: place the sample to be tested in a high-low temperature cycle box, and set the conditions: place in 45℃ for 24 hours, then recover to room temperature for 12 hours, then place in 15℃ for 24 hours, then recover to room temperature for 12 hours, which is one high-low temperature cycle. Each sample to be tested needs to be tested for six cycles, and then its stability is observed.

[0120] The results are shown in Tables 7, 8 and 9.

[0121] In Tables 7-9, “O” indicates that the emulsification state is uniform and there is no abnormality. “X” indicates that the state is abnormal (oil separation, demulsification, particle precipitation, etc.).

[0122] Table 7: 0-day sample test results

[0123]

[0124] Table 8: Stability condition test results

[0125]

[0126] Table 9: Stability condition test results

[0127]

[0128] “ / ” indicates no data.

[0129] Conclusion:

[0130] (1) Compared with the formula lacking any one of the natural high molecular emulsifier, phospholipid emulsifier and anionic emulsifier, the formula obtained by simultaneously using the natural high molecular emulsifier, phospholipid emulsifier and anionic emulsifier as the emulsifier has more excellent appearance, appearance, viscosity and ceramide NP content stability under high temperature, refrigeration (0℃), freezing (-15℃), room temperature, light, high-low temperature cycle and other conditions, which indicates that the natural high molecular emulsifier, phospholipid emulsifier and anionic emulsifier provided by the present application play a synergistic role.

[0131] (2) Compared with other oil-soluble solvents (such as caprylic acid / capric acid triglyceride), the use of the alkyl alcohol solvent (such as octyldodecanol) provided by the present application is more conducive to improving the appearance and appearance, viscosity, and stability of the ceramide NP content of the obtained ceramide NP composition under the conditions of high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high-low temperature cycle, and the like, and has an unexpected technical effect.

[0132] (3) Compared with other natural high molecular emulsifiers (such as glycerol stearate citrate, coconut glucoside, or arachin glucoside), the use of the natural high molecular emulsifier (such as inulin lauryl carbamate) provided by the present application is more conducive to improving the appearance and appearance, viscosity, and stability of the ceramide NP content of the obtained ceramide NP composition under the conditions of high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high-low temperature cycle, and the like, and has an unexpected technical effect.

[0133] (4) Compared with other phospholipid emulsifiers (such as hydrogenated lyso-egg phospholipid, hydrogenated egg phospholipid, or hydroxylated egg phospholipid), the use of the lecithin provided by the present application is more conducive to improving the appearance and appearance, viscosity, and stability of the ceramide NP content of the obtained ceramide NP composition under the conditions of high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high-low temperature cycle, and the like, and has an unexpected technical effect.

[0134] (5) Compared with other thickening agents (such as CAESALPINIA SPINOSA gum, xanthan gum, or hydrogenated xanthan gum), the use of the propylene glycol alginic acid ester provided by the present application as a thickening agent is more conducive to improving the appearance and appearance, viscosity, and stability of the ceramide NP content of the obtained ceramide NP composition under the conditions of high temperature, refrigeration (0°C), freezing (-15°C), room temperature, light, high-low temperature cycle, and the like, and has an unexpected technical effect.

[0135] The method of the present application has been described by way of preferred embodiments, and related personnel can obviously make changes or appropriate changes and combinations to the methods and applications described herein within the content, spirit, and scope of the present application to realize and apply the present application technology. Those skilled in the art can refer to the content herein to appropriately improve the process parameters. It is particularly pointed out that all similar substitutions and changes are obvious to those skilled in the art, and they are considered to be included in the present application.

Claims

1. A composition characterized in that, comprising: an active ingredient, an emulsifier, a thickening agent, and a solvent; the active ingredient is a ceramide NP; the emulsifier includes an anionic emulsifier, a natural high-molecular emulsifier, a nonionic emulsifier, and a phospholipid emulsifier; the solvent includes water, a polyol, and an oil-soluble solvent; the polyol includes 1,3-butanediol; the thickening agent is propylene glycol alginate; the natural high-molecular emulsifier is inulin lauryl carbamate; the phospholipid emulsifier is lecithin; the oil-soluble solvent includes an alkyl alcohol solvent; the alkyl alcohol solvent is octyldodecanol; the anionic emulsifier is sodium stearoyl glutamate; the nonionic emulsifier is polyglyceryl-10 stearate; the content of the ceramide NP is 0.010 wt% - 2.000 wt%, the content of the anionic emulsifier is 0.010 wt% - 0.400 wt%, the content of the natural high-molecular emulsifier is 0.050 wt% - 1.000 wt%, the content of the nonionic emulsifier is 0.100 wt% - 3.000 wt%, the content of the phospholipid emulsifier is 0.010 wt% - 0.600 wt%, the content of the thickening agent is 0.0002 wt% - 0.500 wt%, the content of the polyol is 2.000 wt% - 5.000 wt%, the content of the oil-soluble solvent is 0.200 wt% - 7.000 wt%, and the balance is water, based on the total mass of the composition.

2. The composition according to claim 1, the content of the ceramide NP is 0.010 wt%, the content of the anionic emulsifier is 0.010 wt%, the content of the nonionic emulsifier is 0.100 wt%, the content of the natural high-molecular emulsifier is 0.050 wt%, the content of the phospholipid emulsifier is 0.010 wt%, the content of the thickening agent is 0.0002 wt%, the content of the polyol is 3.500 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 0.200 wt%, and the balance is water, based on the total mass of the composition; or the content of the ceramide NP is 2.000 wt%, the content of the anionic emulsifier is 0.400 wt%, the content of the nonionic emulsifier is 3.000 wt%, the content of the natural high-molecular emulsifier is 1.000 wt%, the content of the phospholipid emulsifier is 0.600 wt%, the content of the thickening agent is 0.500 wt%, the content of the polyol is 3.500 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 7.000 wt%, and the balance is water, based on the total mass of the composition; or the content of the ceramide NP is 2.000 wt%, the content of the anionic emulsifier is 0.400 wt%, the content of the nonionic emulsifier is 3.000 wt%, the content of the natural high-molecular emulsifier is 1.000 wt%, the content of the phospholipid emulsifier is 0.600 wt%, the content of the thickening agent is 0.500 wt%, the content of the polyol is 3.500 wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 7.000 wt%, and the balance is water, based on the total mass of the composition; The content of the ceramide NP is 1.000wt%, the content of the anionic emulsifier is 0.300wt%, the content of the non-ionic emulsifier is 1.000wt%, the content of the natural high molecular emulsifier is 0.500wt%, the content of the phospholipid emulsifier is 0.200wt%, the content of the thickening agent is 0.300wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000wt%, and the balance is water, calculated based on the total mass of the composition; or The content of the ceramide NP is 1.000wt%, the content of the anionic emulsifier is 0.300wt%, the content of the non-ionic emulsifier is 1.000wt%, the content of the natural high molecular emulsifier is 0.200wt%, the content of the phospholipid emulsifier is 0.200wt%, the content of the thickening agent is 0.300wt%, the content of the polyol is 3.500wt%, the oil-soluble solvent is an alkyl alcohol solvent, the content of the alkyl alcohol solvent is 5.000wt%, and the balance is water, calculated based on the total mass of the composition.

3. A process for the preparation of a composition according to any one of claims 1-2, characterized in that, It comprises the following steps: Step (1): mixing and dispersing each component in component 2 to obtain component 2 mixture; then mixing and heating each component in component 1 to obtain component 1 mixture, adding component 2 mixture into component 1 mixture, homogenizing, defoaming to obtain mixture A; component 1 comprises water, anionic emulsifier, phospholipid emulsifier, natural high molecular emulsifier and part of the formula amount of polyol; component 2 comprises thickening agent and the remaining formula amount of polyol; Step (2): heating and dissolving component 3 to obtain mixture B; component 3 comprises non-ionic emulsifier, active ingredient and oil-soluble solvent; Step (3): mixing mixture A and mixture B, homogenizing, defoaming to obtain the composition.

4. The method according to claim 3, the part of the formula amount of polyol in step (1) is three-sevenths to five-sevenths of the formula amount of polyol.

5. The method according to claim 3, the part of the formula amount of polyol in step (1) is four-sevenths of the formula amount of polyol.

6. The method according to any one of claims 3-5, the heating temperature of component 1 in step (1) is 80-90℃; and / or The homogenizing speed of step (1) is 2500 rpm-3500 rpm; and / or The homogenizing time of step (1) is 2-6 minutes; and / or The defoaming of step (1) is vacuum defoaming; and / or The heating and dissolving temperature of step (2) is 80-95℃; and / or The homogenizing speed of step (3) is 2500 rpm-3500 rpm; and / or The homogenizing time of step (3) is 3-8 minutes; and / or The defoaming of step (3) is vacuum defoaming.

7. Use of the composition according to any one of claims 1 to 2 or of the composition obtained according to any one of claims 3 to 6 for the manufacture of a cosmetic product.

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