Scalp and hair care composition and preparation method thereof
Through a scalp hair care composition containing a variety of natural extracts and fullerenes, existing products cannot effectively solve the problem of damage to scalp barrier and microecological damage, and achieve multi-effect care effects, including anti-detachment, oil control, anti-iteration, anti-inflammatory, etc.
Patent Information
- Application Number
- CN202510378281.2
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2025-03-28
- Publication Date
- 2025-04-25
- Estimated Expiration
- Not applicable · inactive patent
AI Technical Summary
The existing scalp and hair care compositions cannot effectively solve problems such as hair loss, oil control, and itching caused by damage to the scalp barrier and microecological damage. The market products have weak effects on the scalp care, single effects, and unsatisfactory actual effects.
A scalp and hair care composition is proposed, which contains moisturizer, Orchidacea extract, Deer Sprout extract, Qinling extract, Gentian extract, Fullerene, skin conditioning agent, preservative, thickener and auxiliary materials. Through the combination of these components, the normal state of the scalp can be restored to achieve multi-effect effects such as anti-detachment, oil control, anti-iteration, anti-inflammatory, and anti-allergic effects.
This composition can promote the proliferation of hair follicle keratinocytes, promote hair growth, inhibit lipid peroxidation, improve cell activity, significantly analgesic and anti-itching, have anti-inflammatory and antibacterial effects, and can treat hair loss, alopecia areata and premature whitening of hair and beard.
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Abstract
Description
Technical Field
[0001] The invention relates to the field of cosmetics, and in particular to a scalp and hair care composition and a preparation method thereof. Background Art
[0002] There are several common types of hair loss in clinical practice: 1. Androgenic alopecia (AGA) has a family history, and the pathological characteristics are the gradual shrinkage of hair follicles and the decrease in hair follicle density. 2. Alopecia areata, localized patchy hair loss, nervous system disorders are important factors. 3. Seborrheic alopecia is related to genetics, androgens, seborrhea, etc., and scalp sensitivity, itching, and greasy are also problems faced by many people. This is due to the damage of the scalp barrier and the destruction of the scalp microecology.
[0003] At present, the anti-hair loss raw materials studied at home and abroad are generally divided into Chinese herbal medicine, synthetic drugs and mixed preparations. Chinese herbal medicine is slow to take effect, synthetic drugs have greater side effects, there is a period of rapid hair loss when first used, and the hair will relapse after discontinuation. At the same time, the hair growth and hair care products on the market have weak scalp care effects, single efficacy, and the actual results are unsatisfactory. Summary of the invention
[0004] In view of the problems of existing scalp and hair care compositions, the present invention provides a scalp and hair care composition and a preparation method thereof, wherein the scalp and hair care composition can restore the scalp to a normal state, and has multiple effects such as preventing hair loss, controlling oil, relieving itching, anti-inflammatory, and anti-allergic, and making the hair strong and shiny.
[0005] A scalp and hair care composition comprises the following components by mass fraction: 5-15% moisturizer, 0.5-10% oriental arborvitae extract, 0.5-10% deer sprout extract, 0.5-10% gentiana extract, 0.5-10% gentiana extract, 0.02%-20% fullerene, 0.05-1% skin conditioner, 0.5-2% preservative, 0.2-0.8% thickener, 0.1-5% auxiliary material, the sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler.
[0006] The scalp and hair care composition proposed in the present invention uses fullerene, Platycladus orientalis, Deer Sprout, Gentiana macrophylla, Gentiana scabra extract and the like as main components, which can restore the normal state of the scalp and play a multi-effect role in preventing hair loss, controlling oil, relieving itching, anti-inflammatory, anti-allergic, making hair strong and shiny, etc.
[0007] In addition, the scalp and hair care composition provided by the present invention may also have the following additional technical features: Preferably, the scalp and hair care composition comprises the following components by mass fraction: 10.5% moisturizer, 5% Platycladus orientalis extract, 5% Deer Sprout extract, 5% Gentiana macrophylla extract, 5% Gentiana extract, 15% fullerene, 0.3% skin conditioner, 0.6% preservative, 0.5% thickener, and 1.81% auxiliary materials, the sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler.
[0008] Preferably, the moisturizing agent is any one or more combinations of glycerol, 1,3-propylene glycol, butylene glycol, 1,2-hexanediol, sorbitol, D-panthenol, and trehalose.
[0009] Preferably, the preservative is a combination of one or more of phenoxyethanol, sodium benzoate, chlorphenesin, ethylhexylglycerin, and parabens.
[0010] Preferably, the skin conditioning agent is a combination of one or more of polypeptides, amino acids, vitamin E, B vitamins, biotin, dipotassium glycyrrhizinate, and bisabolol.
[0011] Preferably, the auxiliary material is any one or more combinations of chelating agents, solubilizing agents, scalp nutrients, sebum regulators, and pH regulators.
[0012] Preferably, the thickener is a combination of any one or more of carbomer, propylene glycol / C10-30 alkyl acrylate crosspolymer, acrylic acid / C10-30 alkyl acrylate crosspolymer, ammonium acryloyldimethyl taurate / beheneth-25 methacrylate crosspolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, xanthan gum, and hydroxyethyl cellulose.
[0013] Preferably, the filler is water.
[0014] The present invention also provides a method for preparing a scalp and hair care composition, comprising the following steps: (1) Homogenize the filler, thickener, humectant, and excipients and heat them to a first preset temperature until they are completely dissolved; (2) When the temperature cools down to below the second preset temperature, add a skin conditioning agent and stir evenly; (3) Add Platycladus orientalis extract, Deer Sprout Extract, Gentiana macrophylla extract, Gentiana scabra extract, and fullerene in sequence, stir evenly, and then filter out the material.
[0015] In addition, the preparation method of the scalp and hair care composition provided by the present invention may also have the following additional technical features: Preferably, the first preset temperature is 65-75°C, and the second preset temperature is 50°C.
[0016] The beneficial effects of the present invention include at least: (1) It can promote the proliferation of hair follicle keratinocytes, promote hair growth, inhibit lipid peroxidation, increase cell activity, quench free radicals, resist ultraviolet damage, and play a role in repairing and protecting cells; (2) It has the effects of inhibiting itching, anti-inflammatory and soothing, accelerating hair growth, increasing the number of hair follicles in the growth phase, strengthening collagen and fixing hair, and has anti-inflammatory, rapid blocking of histamine channels, and rapid antipruritic effects; (3) It has significant analgesic and antipruritic effects, and has certain anti-inflammatory and antibacterial effects, as well as the effect of treating hair loss, alopecia areata, and premature graying of hair.
[0017] Additional aspects and advantages of the present invention will be given in part in the following description and in part will be obvious from the following description, or will be learned through practice of the present invention. DETAILED DESCRIPTION
[0018] In order to make the purpose, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below in conjunction with the examples. Several embodiments of the present invention are given in the examples. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.
[0019] Example 1 A scalp and hair care composition comprises the following components by mass fraction: 10.5% of a moisturizing agent, 5% of an arborvitae extract, 5% of a scutellaria baicalensis extract, 5% of a gentiana macrophylla extract, 5% of a gentiana extract, 15% of a fullerene, 0.3% of a skin conditioner, 0.6% of a preservative, 0.5% of a thickener, and 1.81% of an auxiliary material, the sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler.
[0020] The moisturizer is any one or more of glycerol, 1,3-propylene glycol, butylene glycol, 1,2-hexanediol, sorbitol, D-panthenol, and trehalose; the preservative is any one or more of phenoxyethanol, sodium benzoate, chlorphenesin, ethylhexylglycerin, and parabens; the skin conditioner is any one or more of polypeptides, amino acids, vitamin E, vitamin B group, biotin, dipotassium glycyrrhizate, and bisabolol; the excipient is any one or more of chelating agents, solubilizing agents, scalp nutrients, sebum regulators, and pH regulators; the chelating agent is any one or more of EDTA disodium and hydroxamic acids; the solubilizing agent is any one or more of PEG-40 hydrogenated castor oil and PEG-60 hydrogenated castor oil. The scalp nutrient component is any one or more of a combination of polypeptides such as type 17 collagen, acetyl tetrapeptide-3, acetyl hexapeptide-1, dipeptide-15, myristoyl pentapeptide, and ceramides; the sebum regulator is any one or more of a combination of PCA zinc, zinc sulfate, and yeast zinc; the pH regulator is any one or more of a combination of citric acid, sodium citrate, and sodium hydroxide; the thickener is any one or more of a combination of carbomer, propylene glycol / C10-30 alkyl acrylate crosspolymer, acrylic acid / C10-30 alkyl acrylate crosspolymer, ammonium acryloyldimethyltaurate / behenyl alcohol polyether-25 methacrylate crosspolymer, hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, xanthan gum, and hydroxyethyl cellulose.
[0021] Specifically, the moisturizer is 6% butylene glycol, 4% 1,3-propylene glycol, and 0.5% 1,2-hexanediol; the skin conditioning agent is 0.15% amino acid, 0.05% vitamin E, and 0.1% sodium hyaluronate; the preservative is 0.5% phenoxyethanol and 0.1% ethylhexylglycerin; the thickener is 0.5% ammonium acryloyldimethyltaurate / behenyl alcohol polyether-25 methacrylate crosspolymer; the auxiliary materials include 0.05% chelating agent, 0.05% solubilizing agent, and 0.1% sodium hyaluronate. .1%, scalp nutrients 1.4%, sebum regulator 0.2%, pH regulator 0.06%, chelating agent is EDTA disodium 0.05%, solubilizing agent is PEG-40 hydrogenated castor oil 0.1%, scalp nutrients are type 17 collagen 0.05%, acetyl tetrapeptide-3 0.8%, ceramides 0.55%, sebum regulator is PCA zinc 0.2%, pH regulator is citric acid 0.01%, sodium citrate 0.05%, and the filler is water; It should be noted that the fullerene herein is specifically XKWF60-II fullerene, and the extraction process of Platycladus orientalis extract, Swertia vulgaris extract, Gentiana macrophylla extract, and Gentiana scabra extract is as follows: The corresponding raw materials are taken and sequentially subjected to the steps of extraction, filtration, flocculation, filtration, decolorization and purification, concentration, membrane filtration, sterilization and detection to obtain the corresponding extract.
[0022] The main components of the composition are fullerene, Platycladus orientalis extract, deer sprout extract, gentiana macrophylla extract, gentiana extract, etc., among which fullerene promotes the proliferation of hair follicle keratinocytes, promotes hair growth, inhibits lipid peroxidation, improves cell activity, can quench free radicals, resist ultraviolet damage, and repair and protect cells. Deer sprout extract has the effects of inhibiting itching, anti-inflammatory and soothing, accelerating hair growth, increasing the number of hair follicles in the growth period, and strengthening collagen for hair fixation. Gentiana extract has anti-inflammatory, quickly blocks histamine channels, and quickly relieves itching. Gentiana macrophylla extract has significant analgesic and antipruritic effects, and has certain anti-inflammatory and antibacterial effects. Platycladus orientalis extract has medicinal uses in treating hair loss, alopecia areata, and premature graying of hair.
[0023] The preparation method of the scalp and hair care composition comprises the following steps: (1) Homogenize the filler, thickener, humectant and excipients and heat to 65-75°C until they are completely dissolved; (2) When the temperature cools down to below 50°C, add the skin conditioner and stir evenly; (3) Add Platycladus orientalis extract, Deer Sprout Extract, Gentiana macrophylla extract, Gentiana scabra extract, and fullerene in sequence, stir evenly, and then filter out the material.
[0024] Example 2 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% of moisturizing agent, 5% of deer sprout extract, 5% of gentiana macrophylla extract, 5% of gentiana extract, 15% of fullerene, 0.3% of skin conditioner, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that the Platycladus orientalis extract is not added in the present embodiment.
[0025] Example 3 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% of moisturizer, 5% of Platycladus orientalis extract, 5% of Gentiana macrophylla extract, 5% of Gentiana scabra extract, 15% of fullerene, 0.3% of skin conditioner, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that the deer sprout extract is not added in the present embodiment.
[0026] Example 4 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% of moisturizing agent, 5% of Platycladus orientalis extract, 5% of Deer Sprout extract, 5% of Gentiana extract, 15% of fullerene, 0.3% of skin conditioning agent, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that the Gentiana macrophylla extract is not added in the present embodiment.
[0027] Example 5 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% of moisturizer, 5% of Platycladus orientalis extract, 5% of Swertia japonica extract, 5% of Gentiana macrophylla extract, 15% of fullerene, 0.3% of skin conditioner, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that the gentian extract is not added in the present embodiment.
[0028] Example 6 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% of moisturizing agent, 5% of Platycladus orientalis extract, 5% of Deer Sprout Extract, 5% of Gentiana macrophylla extract, 5% of Gentiana scabra extract, 0.3% of skin conditioner, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that fullerene is not added in the present embodiment.
[0029] Example 7 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% of moisturizing agent, 0.5% of Platycladus orientalis extract, 5% of Deer Sprout Extract, 5% of Gentiana macrophylla extract, 5% of Gentiana scabra extract, 15% of fullerene, 0.3% of skin conditioning agent, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that the mass fraction of the Platycladus orientalis extract in the present embodiment is 0.5%.
[0030] Example 8 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% moisturizer, 10% Platycladus orientalis extract, 5% Deer Sprout extract, 5% Gentiana macrophylla extract, 5% Gentiana scabra extract, 15% fullerene, 0.3% skin conditioner, 0.6% preservative, 0.5% thickener, and 1.81% auxiliary material. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and embodiment 1 is that the mass fraction of the Platycladus orientalis extract in the present embodiment is 10%.
[0031] Example 9 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% moisturizer, 5% Platycladus orientalis extract, 0.5% deer sprout extract, 5% Gentiana macrophylla extract, 5% gentiana extract, 15% fullerene, 0.3% skin conditioner, 0.6% preservative, 0.5% thickener, and 1.81% auxiliary material. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and embodiment 1 is that the mass fraction of the deer sprout extract in the present embodiment is 0.5%.
[0032] Example 10 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% moisturizer, 5% Platycladus orientalis extract, 10% deer sprout extract, 5% Gentiana macrophylla extract, 5% gentiana extract, 15% fullerene, 0.3% skin conditioner, 0.6% preservative, 0.5% thickener, and 1.81% auxiliary material. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and embodiment 1 is that the mass fraction of the deer sprout extract in the present embodiment is 10%.
[0033] Embodiment 11 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% of moisturizing agent, 5% of Platycladus orientalis extract, 5% of Swertia villosa extract, 0.5% of Gentiana macrophylla extract, 5% of Gentiana scabra extract, 15% of fullerene, 0.3% of skin conditioner, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that the mass fraction of the Gentiana macrophylla extract in the present embodiment is 0.5%.
[0034] Example 12 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% of moisturizing agent, 5% of Platycladus orientalis extract, 5% of Swertia villosa extract, 10% of Gentiana macrophylla extract, 5% of Gentiana scabra extract, 15% of fullerene, 0.3% of skin conditioner, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that the mass fraction of the Gentiana macrophylla extract in the present embodiment is 10%.
[0035] Example 13 The present embodiment provides a scalp and hair care composition, which comprises the following components by mass fraction: 10.5% of moisturizing agent, 5% of Platycladus orientalis extract, 5% of Deer Sprout Extract, 5% of Gentiana macrophylla extract, 0.5% of Gentiana extract, 15% of fullerene, 0.3% of skin conditioner, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that the mass fraction of the Gentiana extract in the present embodiment is 0.5%.
[0036] Embodiment 14 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% moisturizer, 5% Platycladus orientalis extract, 5% Swertia japonica extract, 5% Gentiana macrophylla extract, 10% gentiana extract, 15% fullerene, 0.3% skin conditioner, 0.6% preservative, 0.5% thickener, and 1.81% auxiliary material. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the first embodiment is that the mass fraction of the gentiana extract in the present embodiment is 10%.
[0037] Embodiment 15 The present embodiment provides a scalp and hair care composition, which comprises the following components by mass fraction: 10.5% of moisturizing agent, 5% of Platycladus orientalis extract, 5% of Deer Sprout Extract, 5% of Gentiana macrophylla extract, 5% of Gentiana scabra extract, 0.02% of fullerene, 0.3% of skin conditioner, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that the mass fraction of the fullerene extract in the present embodiment is 0.02%.
[0038] Example 16 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% of moisturizing agent, 5% of Platycladus orientalis extract, 5% of Deer Sprout Extract, 5% of Gentiana macrophylla extract, 5% of Gentiana scabra extract, 20% of fullerene, 0.3% of skin conditioner, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the first embodiment is that the mass fraction of the fullerene extract in the present embodiment is 20%.
[0039] Embodiment 17 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% of moisturizing agent, 0.5% of Platycladus orientalis extract, 0.5% of deer sprout extract, 0.5% of Gentiana macrophylla extract, 0.5% of fullerene, 0.3% of skin conditioner, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that the mass fraction of the Platycladus orientalis extract in the present embodiment is 0.5%, the mass fraction of the Deer sprout extract is 0.5%, the mass fraction of the Gentiana macrophylla extract is 0.5%, the mass fraction of the Gentiana macrophylla extract is 0.5%, and the mass fraction of the fullerene is 0.02%.
[0040] Embodiment 18 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% of moisturizing agent, 10% of Platycladus orientalis extract, 10% of Swertia vulgaris extract, 10% of Gentiana macrophylla extract, 10% of Gentiana scabra extract, 20% of fullerene, 0.3% of skin conditioning agent, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that the mass fraction of the Platycladus orientalis extract in the present embodiment is 10%, the mass fraction of the Swertia vulgaris extract is 10%, the mass fraction of the Gentiana macrophylla extract is 10%, the mass fraction of the Gentiana scabra extract is 10%, and the mass fraction of the fullerene is 20%.
[0041] Embodiment 19 The present embodiment provides a scalp and hair care composition, which comprises the following components by mass fraction: 10.5% of moisturizing agent, 0.5% of Platycladus orientalis extract, 5% of Deer Sprout Extract, 5% of Gentiana macrophylla extract, 5% of Gentiana scabra extract, 0.02% of fullerene, 0.3% of skin conditioner, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that the mass fraction of the Platycladus orientalis extract in the present embodiment is 0.5%, and the mass fraction of the fullerene is 0.02%.
[0042] Embodiment 20 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% moisturizer, 10% Platycladus orientalis extract, 5% Deer Sprout extract, 5% Gentiana macrophylla extract, 5% Gentiana scabra extract, 20% fullerene, 0.3% skin conditioner, 0.6% preservative, 0.5% thickener, and 1.81% auxiliary material. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that the mass fraction of the Platycladus orientalis extract in the present embodiment is 10%, and the mass fraction of the fullerene is 20%.
[0043] Embodiment 21 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% of moisturizing agent, 5% of Platycladus orientalis extract, 0.5% of deer sprout extract, 0.5% of Gentiana macrophylla extract, 0.5% of Gentiana scabra extract, 15% of fullerene, 0.3% of skin conditioner, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that the mass fraction of the deer sprout extract, the mass fraction of the Gentiana macrophylla extract, and the mass fraction of the Gentiana scabra extract in the present embodiment is 0.5%, 0.5%, and 0.5%.
[0044] Embodiment 22 The present embodiment provides a scalp and hair care composition, which includes the following components by mass fraction: 10.5% of moisturizing agent, 5% of Platycladus orientalis extract, 10% of deer sprout extract, 10% of Gentiana macrophylla extract, 10% of Gentiana scabra extract, 15% of fullerene, 0.3% of skin conditioner, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and the embodiment 1 is that the mass fraction of the deer sprout extract, the mass fraction of the Gentiana macrophylla extract, and the mass fraction of the Gentiana scabra extract in the present embodiment is 10%, 10%, and 10%.
[0045] Comparative Example 1 This control example is basically the same as Example 1, except that: in this control example, Platycladus orientalis extract, Deer Sprout Extract, Gentiana Macrophylla Extract, Gentiana Extract, and fullerene are not added.
[0046] Comparative Example 2 This control example is basically the same as Example 1, except that: in this control example, Platycladus orientalis extract and fullerene are not added.
[0047] Comparative Example 3 This control example is basically the same as Example 1, except that: in this control example, no deer sprout extract, gentiana macrophylla extract, or gentiana extract is added.
[0048] In order to verify the beneficial effects of the present invention, the present invention conducted the following series of experiments: 1. Toxicological Experiment 1. Acute eye irritation test Test object: The scalp and hair care composition provided in Example 1 was used as the test object sample; Experimental animals and breeding environment: 3 healthy adult New Zealand rabbits, ordinary grade, weighing 2.0-2.5 kg, all female, purchased from Jinan Xilingjiao Breeding Center, the experimental animal production license number is SCXK (Lu) 20200004, the experimental animal quality certificate number is NO.370822240100114717, the animals were raised in the animal room after purchase, the temperature of the breeding room was 16-26 ° C, the relative humidity was 30%-70%, the experimental animal environment use license number is: SYXK (E) 2023-0096, the feed was purchased from Jiangsu Medison Biomedicine Co., Ltd., the license number is Su Feed Certificate (2023) 10030, the experimental animal feed quality certificate number is: NO.240618; Test method: Before the test, the animals were adapted to the experimental animal room environment for 3 days. Within 24 hours before the start of the test, both eyes of each rabbit were examined with 2% sodium fluorescein solution, handheld slit lamp and direct ophthalmoscope. Rabbits with eye irritation symptoms, corneal defects and conjunctival damage were not used for the test. The lower eyelid of one eye of the rabbit was gently pulled open, and 0.1 mL of the test substance sample was dripped into the conjunctival sac, so that the upper and lower eyelids were passively closed for 1 second to prevent the loss of the test substance. The other eye was not treated as a self-control; the animal eyes were examined 1 hour, 24 hours, 48 hours, 72 hours after the dripping of the test substance, and on the 4th and 7th days. If no irritation reaction occurred within 72 hours, the test could be terminated, and the score of eye irritation reaction was recorded according to the "Safety Technical Specifications for Cosmetics" (2015 edition). The test results are shown in Table 1: Table 1: Results of acute eye irritation test on rabbits by the test samples
[0049] According to Table 1, the results of the acute eye irritation of the test samples to rabbits are: non-irritating under non-rinsing conditions.
[0050] 2. Multiple skin irritation tests Test object: The scalp and hair care composition provided in Example 1 was used as the test object sample; Experimental animals and breeding environment: 4 healthy adult New Zealand rabbits, ordinary grade, weighing 2.0-2.5 kg, all female, purchased from Jinan Xilingjiao Breeding Center, the experimental animal production license number is SCXK (Lu) 20200004, the experimental animal quality certificate number is NO.370822240100117948, the animals were raised in the animal room after purchase, the temperature of the breeding room was 16-26 ° C, the relative humidity was 30%-70%, the experimental animal environment use license number is SYXK (E) 2022-0132, the feed was purchased from Jiangsu Medison Biomedicine Co., Ltd., the license number is Su Feed Certificate (2023) 10030, and the experimental animal feed quality certificate number is NO.240615; Test method: Before the test, the animals were adapted to the experimental animal room environment for 3 days. Four rabbits were selected and the hair on both sides of the back spine was removed. The hair removal area was about 3cm×3cm on each side. After 24 hours of observation, 0.5mL of the test sample was applied to the hair removal area on one side of the undamaged rabbit, with an application area of 2.5cm×2.5cm. The skin of the hair removal area on the other side was used as a control. Apply once a day for 14 consecutive days. Starting from the second day, the hair should be trimmed before each application, and the residual test substance should be removed with warm water. The skin reaction of the application site was observed 1 hour after the removal of the test substance, and the relevant provisions of the "Safety Technical Specifications for Cosmetics" (2015 Edition) were followed: Skin irritation reaction scoring. After the test, the total score for 14 days, the average score of each animal for 14 days, and the average score of each animal per day were calculated, and the skin irritation intensity was graded. The test results are shown in Table 2: Table 2: Results of multiple skin irritation tests on rabbits with the test samples
[0051] According to Table 2, the results of multiple skin irritation tests of the test samples on rabbits are: non-irritating.
[0052] 3. Skin allergy test Test substance: The scalp and hair care composition provided in Example 1 was used as the test substance as it is; Positive control: 2,4-dinitrochlorobenzene, batch number: 202203271, manufacturer: Chengdu Borite Chemical Technology Co., Ltd.; solvent: acetone, induction concentration: 1.0%, excitation concentration: 0.1%, dosage: 0.2mL; Experimental animals and breeding environment: 30 healthy adult Hartley guinea pigs, ordinary grade, weighing 300-500 g, all female, were purchased from Jinan Xilingjiao Breeding Center, with experimental animal production license number SCXK (Lu) 20200004, and experimental animal quality certificate number NO.370822240100118027. After purchase, the animals were raised in the animal room with a temperature of 18-29 °C and a relative humidity of 30%-70%. The experimental animal environment use license number is SYXK (E) 2022-0132. Feed was purchased from Jiangsu Medison Biomedicine Co., Ltd. with license number: Su Feed Certificate (2023) 10030, and experimental animal feed quality certificate number: NO.240610. Test method: The skin allergy test was conducted on the test samples according to the "Technical Specifications for Safety of Cosmetics" (2015 edition). The animals were adapted to the experimental animal room environment for 3 days before the test. Induced contact: 24 hours before the test, the left side of the guinea pig's back was depilated, and the depilation range was about 4cm 2 . During the test, 0.2 mL of the test substance was applied to the hairless area of the experimental animal, covered with two layers of gauze and one layer of cellophane, and then fixed with a non-irritating tape for 6 hours. The same method was repeated on the 7th and 14th days. The negative control group was not treated, and the positive control group was treated with 1.0% 2,4-dinitrochlorobenzene. Provocative contact: 14 days after the last induction, 0.2 mL of the test substance sample was applied to the hairless area on the right side of the experimental animal (hair was removed 24 hours before contact), covered with two layers of gauze and one layer of cellophane, and then fixed with a non-irritating tape for 6 hours. The negative control group was treated with the test substance in the same way during the provocative contact, and the positive control group was treated with 0.1% 2,4-dinitrochlorobenzene. Skin allergic reactions were observed 24 hours and 48 hours after the provocative contact, and the skin reaction scores and sensitization intensity were graded according to the "Technical Specifications for Safety of Cosmetics". The results are shown in Table 3: Table 3: Results of the skin allergy test of the test substance in guinea pigs (BT method)
[0053] Note: ① The starting body weight and ending body weight are expressed as mean ± SD; ② In the skin reaction intensity column, the proportion of the number of animals that react to the number of tested animals when the skin reaction score is 0, 1, 2, 3, or 4 should be filled in.
[0054] According to Table 3, the results of the skin allergy test of the test sample on guinea pigs are: no skin allergy was observed.
[0055] 4. Skin phototoxicity test Test substance: The scalp and hair care composition provided in Example 1 was used as the test substance as it is; Positive control: 2,4-dinitrochlorobenzene, batch number: 202203271, manufacturer: Chengdu Borite Chemical Technology Co., Ltd.; solvent: acetone, induction concentration: 1.0%, excitation concentration: 0.1%, dosage: 0.2mL; Experimental animals and feeding environment: 6 healthy adult Hartley guinea pigs, ordinary grade, weighing 350-500 g, half male and half female, were purchased from Jinan Xilingjiao Breeding Center, with experimental animal production license number SCXK (Lu) 20200004 and experimental animal quality certificate number NO.370822240100118173. After purchase, the animals were kept in the animal room with a temperature of 18-29 °C and a relative humidity of 30%-70%. The experimental animal environment use license number is SYXK (E) 2022-0132. Feed was purchased from Jiangsu Medison Biomedicine Co., Ltd. with license number: Su Feed Certificate (2023) 10030 and experimental animal feed quality certificate number: NO.240610. UV light source: The manufacturer is Tianjin Development Zone Hepu Industry and Trade Co., Ltd., model is HOPE-MED8130C; Test method: The samples were subjected to skin phototoxicity test according to the "Technical Specifications for Safety of Cosmetics" (2015 edition). Determination of UV light intensity: Before the test, a radiation meter was used to measure the light intensity (mW / cm 2 ), calculated on the average value, calculation of UV light source irradiation time: irradiation dose is 10J / cm 2 , calculate the irradiation time according to the following formula: irradiation time = irradiation dose / light intensity, average light intensity and irradiation time: UVA (wavelength 365nm) average light intensity 6.50mW / cm 2 , the irradiation time was 24 minutes and 57 seconds, and the animals were adapted to the experimental animal room environment for 3 days before the test. 24 hours before the test, the guinea pig's back was depilated and four intact skins were selected. The depilated area of each piece was about 2cm×2cm, with areas 1 and 3 on the left and areas 2 and 4 on the right. The animal was fixed, and 0.2mL of the test substance was applied to the depilated areas 1 and 2 of the animal. After 30 minutes, the depilated areas 1 and 3 were covered with aluminum foil, fixed with tape, and the right side was irradiated with UVA. After the end, the skin reaction was observed at 1, 24, 48 and 72 hours respectively. The positive control group was tested in the same way. The skin reaction was scored according to the "Technical Specifications for Safety of Cosmetics" (2015 edition), and the results are shown in Table 4: Table 4: Results of the original phototoxicity test of the test substance on guinea pig skin
[0056] According to Table 4, the results of the phototoxicity test of the test samples on guinea pig skin are: no skin phototoxicity was observed.
[0057] 5. Bacterial reverse mutation test Test strains and test substances: Salmonella typhimurium TA1535, TA97a, TA98, TA100, TA102, source: Moltox Company, USA, the scalp and hair care composition provided in Example 1 was used as the test substance; Metabolite activation system: Rat liver homogenate (S 9 ), source: Moltox, USA, batch number: 4661, S 9 The mixed solution contains S 9 10% of the components and supplemented cofactors were used as the in vitro metabolic activation system for this test; Treatment of test substance: sterile ultrapure water was used as solvent during the test, and the test substance was prepared into a series of test solutions with corresponding doses. The pre-test used 10000μg / dish as the highest dose, and there were 4 dose groups including 5000μg / dish, 2500μg / dish, and 1250μg / dish. The pre-test results showed that the test substance had good solubility at doses of 10000μg / dish and below; under the condition of adding metabolic activation system, the test substance began to inhibit bacteria when the dose reached 5000μg / dish, the background bacteria of TA98 became clear, and the number of TA102 reverse mutation colonies decreased significantly; under the condition of not adding metabolic activation system, the test substance began to inhibit bacteria when the dose reached 2500μg / dish, the background bacteria of TA97a and TA100 became clear, and the number of TA102 reverse mutation colonies decreased significantly. 9 and without S 9 , the minimum inhibitory doses under the two conditions were 5000μg / dish and 2500μg / dish respectively; Experimental method: Plate incorporation method: 2.0 mL of top agar medium containing 0.5 mmol / L histidine-0.5 mmol / L biotin solution was dispensed into test tubes and kept warm in a 45°C water bath. Then, 0.1 mL of the test strain enrichment solution, 0.1 mL of the test substance solution (or solvent, positive control substance, no addition to the blank control group) and 0.5 mL of phosphate buffer (without S) were added to each tube in turn. 9 Condition) or S 9 Mixed solution 0.5mL (add S 9 Conditions), mix and pour onto the bottom culture medium plate, set up three parallel plates for each test point, and incubate the plate upside down at 37℃ incubator for 48h after solidification, and count the number of reverted colonies on each plate; Result judgment: If the number of revertant colonies of the test substance TA1535 is three times or more than that of the solvent control, and the number of revertant colonies of the test substances TA97a, TA98, TA100, and TA102 is two times or more than that of the solvent control, and there is a dose-response relationship or a positive reaction occurs under any dose condition and is repeatable, then the test substance is judged to be mutagenic. After the test sample is tested with five test strains, as long as one test strain is positive, regardless of the addition of S 9 Or without S 9 If the test results are positive under the conditions, the test substance can be judged as mutagenic in the bacterial reverse mutation test. The five test strains are positive in the presence of S 9 and without S 9 If all the conditions are negative, the test substance can be judged as mutagenic negative; The test results are shown in Table 5: Table 5: Bacterial reverse mutation test results
[0058] According to Table 5, the results of the bacterial reverse mutation test of the test samples are: no mutagenicity was observed with or without the addition of the metabolic activation system.
[0059] 6. In vitro mammalian cell chromosome aberration test Test strain and test substance: Chinese hamster lung (CHL) cell strain, purchased from Synbio (Shanghai) Biotechnology Co., Ltd., the scalp and hair care composition provided in Example 1 was used as the test substance as is; Metabolite activation system: Rat liver homogenate (S 9 ), source: Moltox, USA, batch number: 4661. 9 The mixed solution contains S 9 10% of the components and supplemented cofactors were used as the in vitro metabolic activation system for this test; Positive: +S 9 : Cyclophosphamide (provided by Beijing Wokai Biotechnology Co., Ltd., batch number: OK210510G) aqueous solution, take 15 mg of cyclophosphamide and add sterile ultrapure water to 10 mL to prepare a solution with a concentration of 1.50 mg / mL, filter and sterilize, and prepare and use it according to the dosage of 1500 μg / mL; -S 9 : Mitomycin C (provided by Jiangxi Ruiweier Biotechnology Co., Ltd., batch number: RWE20220813) aqueous solution, take 5 mg of mitomycin C (MMC) and add sterile ultrapure water to 100 mL to prepare a solution with a concentration of 0.05 mg / mL, filter and sterilize, and prepare and use it according to the dosage of 50 μg / mL; Cytotoxicity test: Well-grown CHL cells were selected and digested with 0.25% trypsin solution and then made into a 1.0×105 / mL cell suspension using culture medium containing 10% fetal bovine serum. 5 mL of the suspension was inoculated into a T25 culture flask and placed in a 5% CO 2 Incubate at 37°C in an incubator for 24 h; after 24 h, discard the culture medium and add 0.1 mL of the test solution or negative control solution of different concentrations. 9 Mixed solution 0.5mL (without S 9 When mixing, add serum-free culture medium to make up to 5 mL. Place in CO 2 Incubate in the incubator for 4 h. After the culture is complete, discard the culture medium in the T25 culture flask, wash the cells twice with PBS, add 5 mL of culture medium containing 10% fetal bovine serum, and place in a CO 2 The cells were cultured in the incubator and harvested within 24 hours. After the culture was completed, the cells were digested with 0.25% trypsin solution and prepared into a cell suspension, and the cells were counted. The test results are shown in Table 6: Table 6: Results of cytotoxicity test of the test substances
[0060] Chromosome aberration test: Select well-growing CHL cells, digest them with 0.25% trypsin solution, and then use culture medium containing 10% fetal bovine serum to make a 1.0×106 cell / mL cell suspension. Inoculate 5 mL in a T25 culture flask and place it in a 5% CO 2 The cells were incubated at 37°C in an incubator for 24 h. After 24 h, the culture medium was discarded and 0.1 mL of the test solution or 0.1 mL of the negative control solution or the positive control solution (0.05 mL of cyclophosphamide, 0.08 mL of mitomycin C), S 9 Mix 0.5 mL of the solution and add serum-free culture medium to make up to 5 mL. After mixing, place in a 5% CO 2 The cells were cultured in an incubator at 37°C. After 4 h of contact, the culture medium in the culture flask was discarded, the cells were washed three times with Hanks solution, 5 mL of serum-containing culture medium was added, and the cells were placed in a 5% CO 2 Cultured in an incubator at 37°C for 24 hours. 4 hours before harvesting cells, colchicine (final concentration of 1 μg / mL) was added to block the metaphase of mitosis. After the culture was completed, the culture medium was decanted and the cells were harvested. Hypotonicity, fixation, slide preparation and staining were performed according to conventional methods. 100 well-dispersed metaphases were selected from each group for chromosome aberration analysis. The results are shown in Table 7: Table 7: Results of in vitro mammalian cell chromosome aberration assay
[0061] According to Tables 6 and 7, the results of the in vitro mammalian cell chromosome aberration test show that no mutagenicity was observed in the in vitro mammalian cell chromosome aberration test of the test substance, with or without the addition of a metabolic activation system.
[0062] 2. Subject Hair Test The criteria for the trial population are as follows: healthy men or women aged 20 to 50 years old, with moderate hair loss, with more than 10 hairs lost by 60 combing methods, without severe skin allergies, skin diseases, scalp or hair problems, non-sensitive scalp, without hair transplantation treatment, and without special hair treatments such as hair dyeing, perming, and styling in the past month.
[0063] The scalp and hair care compositions provided in the above examples and control examples were prepared into corresponding hair care solutions, and the test subjects were divided into groups according to the number of subjects in the examples and control examples, with 4 subjects in each group, and the corresponding hair care solutions were sprayed on the hairline once in the morning and evening every day, 1-1.5 ml each time; After four and eight weeks of use, the subjects in each group were evaluated for hair density, hair loss counts, and photos of overall hair density and hairline were taken. The measured values and differences at each time point were tested for normal distribution. If they were normally distributed, a t-test was performed. If they were not normally distributed, a Wilcoxon test was performed for the before-and-after comparison, a Mann-Whitney test was performed for the inter-group comparison, a two-correlated sample rank sum test was used for the before-and-after comparison, and an independent sample t-test or rank sum test was used for the inter-group comparison. The results were compared with those before the use of the hair care solution to determine the improvement rate of hair loss counts and hair density. The corresponding results are shown in Table 8-1 and Table 8-2: Table 8-1: Results of hair loss count improvement and hair density improvement after four and eight weeks in each example
[0064] Table 8-2: Results of the improvement rate of hair loss count and hair density of each control example after four weeks and eight weeks
[0065] Please refer to Table 8-1 and Table 8-2. For comparison examples 2-6, when one of the arborvitae extract, scutellaria baicalensis extract, gentiana macrophylla extract, and fullerene is missing, the hair loss count improvement rate and the hair density improvement rate are significantly lower than those in Example 1. For comparison examples 3, 4, and 5, when one of the scutellaria baicalensis extract, gentiana macrophylla extract, and gentiana macrophylla extract is missing, the hair loss count improvement rate and the hair density improvement rate are also lower than those in Example 1, but the magnitude of the decrease is not as high as that in Examples 2 and 6. For comparison examples 7-16, when the content of the arborvitae extract, scutellaria baicalensis extract, gentiana macrophylla extract, and fullerene in the scalp and hair care composition is too high or too low, the hair loss count improvement rate and the hair density improvement rate will also be affected. If the content is too low, the best effect cannot be achieved, and if the content is too high, the effects of other components may be partially affected. However, for comparison examples 2 and 9, the hair loss count improvement rate and the hair density improvement rate are also relatively Excellent, while for Control Example 1, Platycladus orientalis extract, deer sprout extract, Gentiana macrophylla extract, gentiana extract, and fullerene were not added, so its hair loss count improvement rate and hair density improvement rate were the lowest. By comparing Example 1 with Control Examples 2 and 3, it can be seen that adding Platycladus orientalis extract, deer sprout extract, Gentiana macrophylla extract, gentiana extract, and fullerene to the scalp and hair care composition can further improve the anti-hair loss performance of the sample, and Platycladus orientalis extract, deer sprout extract, Qinjiao extract, gentian extract, and fullerene can play a synergistic role in enhancing the anti-hair loss effect. At the same time, according to the above test data, it can be seen that Platycladus orientalis extract and fullerene are the main scalp and hair care ingredients, deer sprout extract, Qinjiao extract, and gentian extract are auxiliary scalp and hair care ingredients, and Platycladus orientalis extract and fullerene can play a synergistic role, and deer sprout extract, Qinjiao extract, and gentian extract can also play a synergistic role.
[0066] 3. Oil control test Purpose of the experiment: Sebum secretion is closely related to sebaceous gland function, and sebaceous gland function is closely related to androgen regulation. 5α-reductase is a membrane protease located in microsomes and cell nuclei. It uses reduced coenzyme NADPH as a hydrogen donor and can catalyze the conversion of testosterone into dihydrotestosterone. Dihydrotestosterone can induce excessive oil secretion of sebaceous glands. By inhibiting the activity of 5α-reductase, the production of dihydrotestosterone is reduced, and the level of sebaceous gland lipid secretion is reduced.
[0067] Test sample and treatment: The scalp and hair care composition provided in Example 1 was used as a test sample, and 20 μL of the sample solution and the negative control (normal saline) were taken respectively → added to the enzyme reaction system for catalysis → the change value of absorbance ΔA within 10 minutes was measured at 340 nm by an ultraviolet spectrophotometer → the enzyme activity U was calculated. The test results are shown in Table 9: Table 9 Enzyme activity results of 5α-reductase
[0068] According to Table 9, the enzyme activity of the negative control (normal saline) is much greater than that of the test sample, indicating that the test sample has a certain enzyme inhibitory activity and a significant effect, proving that the test sample has an oil control effect.
[0069] 4. Skin Sensation Test Test subject criteria: healthy male or female, aged 18 to 60 years old, volunteers with sensitive scalp, dandruff, oily scalp, no serious systemic diseases, no immunodeficiency or autoimmune diseases, no allergic diseases, no history of allergies to cosmetics and other topical preparations, no skin treatment, beauty treatment or other tests that may affect the results on the test site, no use of hormonal drugs or immunosuppressants in the past month, no scars, pigmentation, atrophy, port-wine stains or other blemishes on the skin test site that may affect the test results.
[0070] Sample and usage: The scalp and hair care composition provided in Example 1 is used as a test sample, and the test sample is evenly sprayed on the scalp and hair roots, and gently massaged with the fingertips until absorbed. It is recommended to use about 3 ml each time, and use it every day for better results. It should be used continuously for 28 days, and during the entire test period, except for the test sample provided, no other similar products can be used in the test area.
[0071] Test plan: Based on the product's claimed efficacy in scalp tightening, oil control, and suitability for sensitive scalps, subjects with sensitive scalp, dandruff, and oily scalp were recruited to use the test product. 30 subjects used the test product for 28 days. According to the principle of randomization, single-blindness, and control, the subjects were asked to fill out and collect 30 questionnaires 14 days and 28 days after using the sample. The results are shown in Tables 10 and 11: Table 10: Satisfaction rate of testers after 14 days of use
[0072] Table 11: Satisfaction rate of testers after 28 days of use
[0073] According to Table 10 and Table 11, after 14 days of use, 100.0% of the subjects felt that the fragrance of the product was pleasant and comfortable; 100.0% of the subjects felt that the texture of the product was refreshing and not sticky; 100.0% of the subjects felt that the product was absorbed quickly; 100.0% of the subjects felt that there was no discomfort when using the product; 100.0% of the subjects felt that the product was mild and non-irritating; 100.0% of the subjects felt that the scalp was comfortable and there was no tingling when using the product; 100.0% of the subjects felt that the scalp was no longer red after using the product; 93.3% of the subjects felt that the scalp had no itching after using the product; 96.7% of the subjects felt that This product is suitable for sensitive scalps; 100.0% of the subjects felt that their scalp became refreshed after using this product; 96.7% of the subjects felt that their scalp became firmer after using this product; 96.7% of the subjects felt that their scalp became firmer after using this product; 96.7% of the subjects felt that their scalp was no longer dry after using this product; 96.7% of the subjects felt that the oiliness of the scalp was improved after using this product; 100.0% of the subjects felt that the oil secretion of the scalp was effectively reduced after using this product; 100.0% of the subjects felt that their hair became moisturized after using this product; 100.0% of the subjects felt that they were generally satisfied with the product; After using the product for 28 days, 100.0% of the subjects felt that the product had a pleasant and comfortable fragrance; 100.0% of the subjects felt that the product had a refreshing and non-sticky texture; 100.0% of the subjects felt that the product absorbed quickly; 100.0% of the subjects felt that the product did not cause discomfort when used; 100.0% of the subjects felt that the product was mild and non-irritating; 100.0% of the subjects felt that the scalp was comfortable and did not feel stinging when using the product; 100.0% of the subjects felt that the scalp was no longer red after using the product; 100.0% of the subjects felt that the scalp did not feel itchy after using the product; 96.7% of the subjects felt that the product was suitable for Sensitive scalp; 100.0% of the subjects felt that their scalp became refreshed after using the product; 96.7% of the subjects felt that their scalp became firmer after using the product; 96.7% of the subjects felt that their scalp became firmer after using the product; 100.0% of the subjects felt that their scalp was no longer dry after using the product; 100.0% of the subjects felt that the product improved the oiliness of the scalp after using it; 100.0% of the subjects felt that the product effectively reduced the oil secretion of the scalp after using it; 100.0% of the subjects felt that their hair became moisturized after using the product; 100.0% of the subjects felt that they were generally satisfied with the product.
[0074] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.
[0075] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.
Claims
1. A scalp and hair care composition, characterized in that: The composition includes the following components by mass fraction: 5-15% moisturizer, 0.5-10% oriental arborvitae extract, 0.5-10% deer sprout extract, 0.5-10% gentiana extract, 0.5-10% gentiana extract, 0.02%-20% fullerene, 0.05-1% skin conditioner, 0.5-2% preservative, 0.2-0.8% thickener and 0.1-5% auxiliary material. The sum of the mass fractions of the above components shall not exceed 100%, and the remainder is filler.
2. The scalp and hair care composition according to claim 1, characterized in that: The scalp and hair care composition comprises the following components by mass fraction: 10.5% of moisturizing agent, 5% of Platycladus orientalis extract, 5% of Deer Sprout extract, 5% of Gentiana macrophylla extract, 5% of Gentiana scabra extract, 15% of fullerene, 0.3% of skin conditioner, 0.6% of preservative, 0.5% of thickener, and 1.81% of auxiliary materials. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler.
3. The scalp and hair care composition according to claim 1, characterized in that: The moisturizing agent is any one or more combinations of glycerol, 1,3-propylene glycol, butylene glycol, 1,2-hexanediol, sorbitol, D-panthenol and trehalose.
4. The scalp and hair care composition according to claim 1, characterized in that: The preservative is a combination of one or more of phenoxyethanol, sodium benzoate, chlorphenesin, ethylhexylglycerin, and parabens.
5. The scalp and hair care composition according to claim 1, characterized in that: The skin conditioning agent is a combination of one or more of polypeptides, amino acids, vitamin E, B vitamins, biotin, dipotassium glycyrrhizinate, and bisabolol.
6. The scalp and hair care composition according to claim 1, characterized in that: The auxiliary material is any one or more combinations of chelating agents, solubilizing agents, scalp nutrients, sebum regulators, and pH regulators.
7. The scalp and hair care composition according to claim 1, characterized in that: The thickener is any one or more of carbomer, propylene glycol / C10-30 alkyl acrylate cross-linked polymer, acrylic acid / C10-30 alkyl acrylate cross-linked polymer, ammonium acryloyldimethyl taurate / beheneth-25 methacrylate cross-linked polymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, xanthan gum, and hydroxyethyl cellulose.
8. The scalp and hair care composition according to claim 1, characterized in that: The filler is water.
9. The method for preparing the scalp and hair care composition according to any one of claims 1 to 8, characterized in that: The following steps are involved: (1) Homogenize the filler, thickener, humectant, and excipients and heat them to a first preset temperature until they are completely dissolved; (2) When the temperature cools down to below the second preset temperature, add a skin conditioning agent and stir evenly; (3) Add Platycladus orientalis extract, Deer Sprout Extract, Gentiana macrophylla extract, Gentiana scabra extract, and fullerene in sequence, stir evenly, and then filter out the material.
10. The method for preparing the scalp and hair care composition according to claim 9, characterized in that: The first preset temperature is 65-75°C, and the second preset temperature is 50°C.
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