Composition for resisting degradation of olive leaf extract and application thereof
By combining the olive olive leaf extract with polyol and citrus fruit extract in a specific proportion, an anti-degradation composition is formed, which solves the problem of olive erurean degradation in the olive olive leaf extract, extends its biological activity retention period, and enhances the efficacy of cosmetics.
Patent Information
- Application Number
- CN202411961821.1
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-30
- Publication Date
- 2025-04-25
AI Technical Summary
Oleurin in oil olive leaf extract is prone to degradation during storage, especially under high temperature conditions, resulting in reduced biological activity and shortened shelf life.
An anti-degradation composition is formed by combining the olive leaf extract with the polyol and citrus fruit extract in a specific proportion. The composition includes olive leaf extract of oleos, polyols (such as 1,3-butanediol) and citrus fruit extract. The weight ratio of the polyol to olive leaf extract is not less than 10:1, and the weight ratio of the olive leaf extract of oleos and citrus fruit extract is 1:2 to 1:4.
Effectively prevent the degradation of oleuropein, prolong the retention period of its biological activity, and enhance the effects of oil control, repair, soothe, and moisturizing in cosmetics.
Smart Images
Figure CN119868220A_ABST
Abstract
Description
Technical Field
[0001] The invention belongs to the technical field of cosmetics, and particularly relates to a composition for resisting degradation of olive leaf extract and application thereof. Background Art
[0002] Oleuropein is a special monoterpene compound belonging to the class of secoiridoid ether terpene glycosides, which is commonly found in the plant tissues of olive trees such as Oleaceae, Ligustrum, and Syringa. Studies have found that oleuropein has a variety of pharmacological and biological activities, such as anti-inflammatory, anti-microbial, antioxidant, anti-tumor, anti-cancer and hypoglycemic. The many activities of oleuropein make olive leaf extract widely used in food, medicine and cosmetics. At present, researchers have reported a lot on the processing and preparation of oleuropein, its biological activity, etc., but rarely study the stability changes of oleuropein in olive leaf extract, and even less study how to prevent the degradation of oleuropein in olive leaf extract.
[0003] Olive leaf extract has attracted much attention in the cosmetics industry due to its richness and has become one of the important ingredients used in the cosmetics industry to soothe the skin and improve skin conditions. On this basis, developing a compound formula of olive leaf extract and other ingredients to enhance the efficacy of the product is not only an innovative development, but also can meet the current consumer demand for efficient and multifunctional skin care products.
[0004] However, the applicant has found that after the skin care products containing olive leaf extract are placed for a period of time, the oleuropein component therein will degrade to a certain extent, especially when placed at a temperature higher than room temperature, which will accelerate the degradation rate. Summary of the invention
[0005] The present invention provides a composition for resisting degradation of olive leaf extract and its application. The composition can effectively prevent the degradation of oleuropein and can synergistically enhance the oil control, repair, soothing and moisturizing effects of the product.
[0006] In order to solve the above technical problems, the technical solution to be adopted in the present invention is:
[0007] The invention provides a composition for resisting degradation of olive leaf extract, the composition comprising olive leaf extract, polyol and citrus fruit extract, wherein the weight ratio of the polyol to the olive leaf extract is not less than 10:1.
[0008] Furthermore, the weight ratio of the olive leaf extract to the citrus fruit extract is 1:2 to 1:4.
[0009] Furthermore, the components of the composition include 2-5 parts of olive leaf extract, no less than 50 parts of polyol, 2-26 parts of citrus fruit extract, and 0-37 parts of water, by weight.
[0010] Furthermore, the polyol is at least one of 1,3-butanediol, 1,3-propylene glycol, 1,2-hexanediol, 1,2-pentanediol, 1,2-octanediol and 1,2-decanediol.
[0011] Preferably, the ratio of the olive leaf extract to 1,3-butanediol is 1:12.6-1:15.
[0012] Furthermore, the composition comprises 5 parts of olive leaf extract, 63 parts of 1,3-butanediol, 10 parts of citrus fruit extract, and 22 parts of water.
[0013] Furthermore, the olive leaf extract includes at least oleuropein.
[0014] The invention also provides application of the composition in preparing cosmetics.
[0015] Furthermore, the cosmetics include essence water, essence liquid, lotion, cream, and facial mask liquid.
[0016] Furthermore, the components of the cosmetic include, by weight: 0.1-20 parts of the composition of claim 1, 5-15 parts of a moisturizer, 0.2-2 parts of a skin conditioner, 0-2 parts of an emollient, 0.1-2 parts of an antioxidant, 0.1-0.5 parts of an emulsifier, 0.1-5 parts of a thickener, 0.3-1 parts of a preservative, 0-10 parts of an emulsifier, 0-0.5 parts of a solid oil, 0-30 parts of a liquid oil, and 12-94.1 parts of water.
[0017] Furthermore, the cosmetic has the effects of oil control, repair, soothing, mildness, non-irritation and moisturizing.
[0018] The invention also provides an essence liquid, which comprises the composition.
[0019] Furthermore, the essence also includes hydroxyethyl urea, diglycerin, ectoine, allantoin, panthenol, sodium hyaluronate, milk thistle fruit extract, arginine, glyceryl glucoside, PEG-12 polydimethylsiloxane crosspolymer, 3-o-ethyl ascorbic acid, PEG / PPG-14 / 7 dimethyl ether, carbomer, ammonium acryloyldimethyltaurate / VP copolymer, p-hydroxyacetophenone, and 1,2-hexanediol.
[0020] Compared with the prior art, the present invention has the following advantages and beneficial effects:
[0021] 1. The present invention combines olive leaf extract and polyol in a scientific ratio, which can effectively prevent the degradation of oleuropein in the olive leaf extract, not only effectively ensuring the biological activity of the raw material during the shelf life, but also extending the shelf life of the functional raw material.
[0022] 2. The composition of the present invention can not only effectively prevent the degradation of oleuropein in olive extract by increasing the proportion of polyols, but also avoid the addition of preservatives in liquid cosmetic raw materials.
[0023] 3. The present invention combines olive leaf extract and citrus fruit extract in a scientific proportion, and proves through effect data that the combined use of the two can play a synergistic role in product efficacy such as oil control, repair, soothing, mild and non-irritating, and moisturizing, thereby improving the use effect and skin feel of the cosmetics prepared by the composition of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS
[0024] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.
[0025] Figure 1 This is a comparison of the red zone photos of subject No. 01 in group A of experiment 5;
[0026] Figure 2 is a comparison of the red zone photographs of subject No. 11 in group A of experiment 5;
[0027] Figure 3 It is a comparison picture of the red area of the subject No. 02 in the experiment group B in Example 5;
[0028] Figure 4 This is a comparison of the red zone photos of subject No. 12 in Experiment B Group in Example 5. DETAILED DESCRIPTION
[0029] The present invention is further described in detail below in conjunction with embodiments. The following embodiments are for explanation of the present invention but the present invention is not limited to the following embodiments.
[0030] A composition for resisting degradation of olive leaf extract, comprising the following components:
[0031] A.Olea europaea leaf extract;
[0032] B. a polyol selected from at least one of 1,3-butanediol, 1,3-propylene glycol, 1,2-hexanediol, 1,2-pentanediol, 1,2-octanediol and 1,2-decanediol;
[0033] C. citrus fruit extract;
[0034] D. Water.
[0035] In terms of weight, (1) component A is 2-5 parts; (2) component B should be ≥50 parts in the entire composition; (3) B:A ≥10:1; (4) A:C = 1:2 to 1:4; (5) component D is 0-37 parts.
[0036] The composition is used in cosmetics, especially cosmetics with oil control, repair, soothing, mild and non-irritating, and moisturizing effects; the cosmetics include essence water, essence liquid, emulsion, cream, and mask liquid.
[0037] The cosmetic comprises the following components: 0.1-20 parts of an anti-oleuropein degradation composition, 5-15 parts of a moisturizer, 0.2-2 parts of a skin conditioner, 0-2 parts of an emollient, 0.1-2 parts of an antioxidant, 0.1-0.5 parts of an emulsifier, 0.1-5 parts of a thickener, 0.3-1 parts of a preservative, 0-10 parts of an emulsifier, 0-0.5 parts of solid fat, 0-30 parts of liquid fat, and 12-94.1 parts of water.
[0038] Example 1
[0039] A composition for resisting degradation of olive leaf extract, comprising: 5 parts of olive leaf extract, 63 parts of 1,3-butylene glycol, 10 parts of citrus fruit extract, and 22 parts of water. After the olive leaf extract, 1,3-butylene glycol, citrus fruit extract and water are uniformly mixed, the sample is used as experimental sample 1.
[0040] Experimental sample 2: 5 parts of olive leaf extract, 50 parts of 1,3-butylene glycol, 10 parts of citrus fruit extract, and 35 parts of water.
[0041] Experimental sample 3: 5 parts of olive leaf extract, 40 parts of 1,3-butylene glycol, 10 parts of citrus fruit extract, and 45 parts of water.
[0042] Comparative sample 1: 5 parts of olive leaf extract, 30 parts of 1,3-butylene glycol, 10 parts of citrus fruit extract, and 55 parts of water. For liquid cosmetic raw materials, without adding preservatives or other preservative substances, the amount of polyol added is generally 30 parts to play a preservative role.
[0043] About 100 mL of experimental sample 1, experimental sample 2, experimental sample 3, and control sample 1 were respectively placed at room temperature, 4°C, and 45°C. The oleuropein content in the four samples was detected by HPLC at 0 weeks, 3 weeks, 5 weeks, and 9 weeks, respectively, to investigate the degradation rate of oleuropein.
[0044] Degradation rate = (actual oleuropein content at 4°C - actual oleuropein content at other conditions in the same test period) / actual oleuropein content at 4°C * 100%.
[0045] The results are shown in Table 1 below. Under normal temperature and high temperature of 45°C, the degradation rate of oleuropein at each cycle node of experimental sample 1 was significantly lower than that of experimental sample 2, experimental sample 3 and control sample 1.
[0046] Table 1 Comparison of degradation rates of oleuropein content in the composition
[0047]
[0048] Example 2
[0049] A composition for resisting oleuropein degradation comprises the following components: 2 parts of olive leaf extract, 60 parts of 1,3-butanediol, 84 parts of citrus fruit extract and 304 parts of water.
[0050] Example 3
[0051] A composition for resisting degradation of olive leaf extract comprises the following components: 3.5 parts of olive leaf extract, 52.5 parts of 1,3-butanediol, 14 parts of citrus fruit extract and 30 parts of water.
[0052] Example 4
[0053] A composition for resisting degradation of olive leaf extract comprises the following components: 4 parts of olive leaf extract, 80 parts of 1,3-butanediol and 16 parts of citrus fruit extract.
[0054] Example 5
[0055] A composition for resisting degradation of olive leaf extract comprises the following components: 2 parts of olive leaf extract, 60 parts of 1,3-butanediol, 4 parts of citrus fruit extract and 34 parts of water.
[0056] Example 6
[0057] An essence, calculated by weight, comprises the following raw materials:
[0058] 20 portions of the experimental sample 1 composition prepared in Example 1;
[0059] Moisturizer: 2 parts of glycerin, 1 part of hydroxyethyl urea, 0.7 parts of diglycerin, 0.5 parts of ectoine, 0.3 parts of allantoin, 0.3 parts of panthenol, 0.2 parts of 1.8 million Da sodium hyaluronate;
[0060] Skin conditioning agent: 1 part of milk thistle fruit extract, 0.2 part of arginine, 0.2 part of glyceryl glucoside;
[0061] Emollient: PEG-12 dimethicone crosspolymer 1 part;
[0062] Antioxidant: 1 part of 3-o-ethyl ascorbic acid;
[0063] Co-emulsifier: PEG / PPG-14 / 7 dimethyl ether 0.4 parts;
[0064] Thickener: Carbomer 0.2 parts, ammonium acryloyldimethyltaurate / VP copolymer 0.1 parts;
[0065] Preservatives: 0.8 parts of p-hydroxyacetophenone, 1 part of 1,2-hexanediol;
[0066] 69.1 parts of water.
[0067] The steps for preparing the serum are as follows:
[0068] (1) The above raw materials are phase-separated as follows: Phase A: 44.1 parts of water, 0.2 parts of carbomer, and 0.1 parts of ammonium acryloyldimethyltaurate / VP copolymer; Phase B: 5 parts of water and 0.2 parts of arginine; Phase C: 2 parts of glycerol, 1 part of 1,2-hexanediol, and 0.2 parts of 1.8 million Da sodium hyaluronate; Phase D: 1 part of hydroxyethyl urea, 0.7 parts of diglycerol, 1 part of PEG-12 polydimethylsiloxane crosspolymer, and 0.4 parts of PEG / PPG-14 / 7 dimethyl ether; Phase E: 20 parts of water, 0.8 parts of p-hydroxyacetophenone, 0.3 parts of allantoin, 0.3 parts of panthenol, 0.5 parts of ectoine, and 1 part of 3-o-ethyl ascorbic acid; Phase F: 20 parts of the experimental sample 1 composition prepared in Example 1, 0.2 parts of glyceryl glucoside, and 1 part of milk thistle fruit extract.
[0069] (2) The preparation steps are as follows:
[0070] 1) Add phase A water into the emulsifier, heat to 60-65℃, add other ingredients of phase A while homogenizing. Then stir for 15 minutes; homogenize for 5 minutes until the material is uniform, and keep warm.
[0071] 2) Premix the raw materials of phase B, stir until completely dissolved, then add to the emulsifier in the previous step, start stirring for 10 minutes, then homogenize at 2000 rpm for 0.5 to 2 minutes until the material is uniform, and keep warm.
[0072] 3) Premix the raw materials of phase C, stir until the material is evenly dispersed, add it to the emulsifier in the previous step, stir for 10 minutes until the material is uniform, and keep warm.
[0073] 4) Add the phase D raw materials directly into the emulsifying pot in the previous step, stir for 10 minutes until the material is uniform, and maintain the negative pressure at -0.07Mpa.
[0074] 5) Premix the raw materials of phase E, heat to 60-65°C and stir until the raw materials are completely dissolved, then add to the emulsifier in the previous step and stir for 10 minutes; homogenize for 0.5-2 minutes until the material is uniform and maintain negative pressure.
[0075] 6) After the above material is cooled to 45°C, add the F phase raw materials into the emulsification pot in the previous step, stir for 10 minutes, homogenize for 1 minute until the material is uniform, and maintain a negative pressure of -0.07Mpa. After discharging, filter the material with a 100-mesh filter cloth.
[0076] The following is a verification test of the degradation of oleuropein in the essence. The experimental steps are as follows:
[0077] (1) Preparation of experimental sample 1: 5 parts of olive leaf extract, 63 parts of 1,3-butylene glycol, 10 parts of citrus fruit extract, and 22 parts of water.
[0078] (2) Comparative sample 2 was prepared (excluding citrus fruit extract, and other components were the same as those of experimental sample 1): 5 parts of olive leaf extract, 63 parts of 1,3-butylene glycol, and 32 parts of water.
[0079] (3) Two essences were prepared: the experimental essence was prepared by using the essence prepared by using the experimental sample 1; the comparative essence was prepared by using the comparative sample 2 instead of the essence prepared by using the experimental sample 1.
[0080] (4) Stability test 1: About 100 mL of the two essences of step (3) were taken and placed at room temperature and 50°C, and the oleuropein content in the samples was detected by high performance liquid chromatography at 0 weeks, 3 weeks, 5 weeks, and 9 weeks, respectively, to investigate the degradation rate of oleuropein.
[0081] The comparison results of oleuropein degradation rate are shown in Table 2 below. The results show that the degradation rate of oleuropein at each cycle node of the experimental essence at room temperature and high temperature of 50°C is significantly lower than that of the control essence. This shows that the application of citrus fruit extract in the composition of the present invention and then in cosmetics has a positive effect on reducing the degradation of oleuropein.
[0082] Table 2 Comparison of oleuropein degradation rate in essence
[0083]
[0084] (5) Stability test 2: Take 50 mL of the experimental essence in step (3) and place it at room temperature, 40°C, 45°C, 50°C, strong light irradiation, light aging for 24 h, and freezing at -18°C. The oleuropein content in the sample was detected by HPLC at 0 weeks, 3 weeks, 5 weeks, and 9 weeks, respectively, to investigate the degradation rate of oleuropein under multiple extreme environmental conditions.
[0085] The comparison results of oleuropein degradation rate are shown in Table 3. The results show that oleuropein in the experimental essence is relatively stable under extreme environmental conditions, and the degradation rate is low; while under high temperature conditions of 50°C, the degradation rate of oleuropein is high, reaching 15%.
[0086] Table 3 Degradation of oleuropein in cosmetic essence under multiple temperature conditions
[0087]
[0088]
[0089] Example 7
[0090] In this example, the efficacy of the composition of the present invention and the olive leaf extract in terms of oil control, repair, soothing, mildness and non-irritation, and moisturizing are compared in terms of human efficacy.
[0091] Experimental sample 1: (same as Example 1) 5 parts of olive leaf extract, 63 parts of 1,3-butylene glycol, 10 parts of citrus fruit extract, and 22 parts of water.
[0092] Comparative sample 2: (excluding citrus fruit extract, other components are the same as experimental sample 1) 5 parts of olive leaf extract, 63 parts of 1,3-butanediol, and 32 parts of water.
[0093] Experimental Group A: Experimental Sample 1 was used to prepare a human efficacy essence (see Table 4 for the specific formula) for human efficacy testing.
[0094] Experimental Group B: Comparative Sample 2 was used to prepare a human efficacy essence (see Table 4 for the specific formula) for human efficacy testing.
[0095] Table 4 Human efficacy trial essence formula
[0096]
[0097] (1) Measurement parameters and related equipment
[0098] Table 5 Measurement parameters and related equipment
[0099]
[0100]
[0101] (2) Measurement method
[0102] 61 subjects with self-reported sensitive skin were recruited (31 in Group A and 30 in Group B) and used the test samples for 28 consecutive days. The blind method and self-control method were used to judge and compare the efficacy of the two samples through semi-subjective evaluation (lactic acid stinging test) and objective evaluation (VISIA was used to collect and analyze the red area on the face of the subjects, and the water content of the stratum corneum, transepidermal water loss, skin hemoglobin content and oil content were measured by various test probes, and the changes in various indicators before and after use were compared).
[0103] (3) Test results
[0104] ①Oil control effect comparison
[0105] The average value and change rate of skin oil secretion are shown in Table 6. Compared with the baseline value before use (D0), the skin oil secretion of Group A and Group B decreased after using the samples, indicating that both samples A and B can improve the oil secretion of the skin. The decrease rate of skin oil secretion in Group A after using the product for 28 days was higher than that in Group B, indicating that the oil control effect of Group A is better than that of Group B.
[0106]
[0107] Table 6 Analysis of the difference in the average value of skin oil secretion And the change rate results statistics
[0108]
[0109] Note: SPSS software was used for statistical analysis. p>0.05 means no statistically significant difference, 0.01<p<0.05 means significant difference, 0.001<p<0.01 means extremely significant difference, and p<0.001 means extremely significant difference.
[0110] ②Comparison of repair effects
[0111] The larger the TEWL value measured by the test probe, the more transepidermal water loss per unit time and unit cross-sectional area, and vice versa. Therefore, the trend of decreasing TEWL value represents the recovery process of transepidermal water loss of barrier-damaged skin. The average value and change rate of skin TEWL are shown in Table 7. Compared with the baseline value before use (D0), the average TWEL value of group A skin showed a downward trend after using the product, and decreased by 17.62% after 28 days of use, which was significantly different from the baseline value (p < 0.01). The results show that sample A has a repair effect. The average TWEL value of group B skin increased after 28 days of using the product, indicating that sample B could not improve the transepidermal water loss of the skin under the test conditions and had no repair effect.
[0112]
[0113] Table 7 Analysis of differences in the mean values of skin TEWL And the change rate results statistics
[0114]
[0115] ③ Comparison of soothing effects
[0116] The skin hemoglobin (EI) value represents the hemoglobin content in the skin. The lower the value measured by the test probe, the lower the hemoglobin content in the skin at that location. The average values and change rates of skin hemoglobin values are shown in Table 8. Compared with the baseline value before use (D0), the skin hemoglobin (EI) values of Group A and Group B decreased after 28 days of use of the product, with a decrease rate of 11.89% and 4.53%, respectively, which were significantly different from the baseline values (p < 0.05), indicating that the soothing effect of sample A is better than that of sample B.
[0117]
[0118] Table 8 Analysis of the difference in the average values of skin hemoglobin EI And the change rate results statistics
[0119]
[0120] ④ Comparison of mild and non-irritating effects
[0121] At room temperature, the subjects' sensitivity reactions were rated on a 4-level scale using a 10% lactic acid solution. The smaller the score value, the lower the degree of lactic acid stinging sensation, as shown in Table 9. Compared with the baseline value before use (D0), the mean lactic acid stinging score results decreased after using products A and B for 28 days, with a decrease rate of 45.83% and 30.00%, respectively, which were significantly different from the baseline values (p < 0.05). This shows that sample A is mild and non-irritating, which is better than sample B.
[0122] Table 9 Lactic acid sting test results
[0123]
[0124] ⑤ Moisturizing effect comparison
[0125] The larger the value measured by the test probe, the higher the moisture content of the stratum corneum of the skin. The test results are shown in Table 10. Compared with the baseline value before use (D0), the moisture content of the stratum corneum of the skin of Group A and Group B increased after 28 days of use, with the increase rates of 12.90% and 3.69% respectively, which were significantly different from the baseline values. This shows that both samples A and B have moisturizing effects, but sample A is better than B.
[0126]
[0127] Table 10 Analysis of the difference in the average water content of the stratum corneum of the skin And the change rate results statistics
[0128]
[0129] Figure 1-Figure 4The following are the comparisons of red area photos of some subjects in group A and group B. The results show that sample A is significantly better than sample B in improving skin redness.
[0130] The comparative tests of the above experiments show that after adding citrus fruit extract, it can synergize with olive leaf extract to increase the efficacy of the product in terms of oil control, repair, soothing, mildness and non-irritation, and moisturizing.
[0131] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit the same. Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for a person skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to replace some of the technical features therein by equivalents. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions claimed to be protected by the present invention.
Claims
1. A composition for resisting degradation of olive leaf extract, characterized in that: The components of the composition include olive leaf extract, polyol, and citrus fruit extract, and the weight ratio of the polyol to the olive leaf extract is not less than 10:
1.
2. The composition according to claim 1, characterized in that The weight ratio of the olive leaf extract to the citrus fruit extract is 1:2 to 1:
4.
3. The composition according to claim 2, characterized in that By weight, the components of the composition include 2-5 parts of olive leaf extract, no less than 50 parts of polyol, 2-26 parts of citrus fruit extract, and 0-37 parts of water.
4. The composition according to claim 1, characterized in that The polyol is at least one of 1,3-butanediol, 1,3-propylene glycol, 1,2-hexanediol, 1,2-pentanediol, 1,2-octanediol and 1,2-decanediol.
5. The composition according to claim 4, characterized in that The ratio of the olive leaf extract to 1,3-butanediol is 1:12.6-1:
15.
6. Use of the composition according to any one of claims 1 to 5 in the preparation of cosmetics.
7. The use according to claim 6, characterized in that: The cosmetics include essence water, essence liquid, emulsion, cream and facial mask liquid.
8. The use according to claim 6, characterized in that: The components of the cosmetics include, by weight: 0.1-20 parts of the composition of claim 1, 5-15 parts of moisturizers, 0.2-2 parts of skin conditioners, 0-2 parts of emollients, 0.1-2 parts of antioxidants, 0.1-0.5 parts of co-emulsifiers, 0.1-5 parts of thickeners, 0.3-1 parts of preservatives, 0-10 parts of emulsifiers, 0-0.5 parts of solid fats and oils, 0-30 parts of liquid fats and oils, and 12-94.1 parts of water.
9. An essence, characterized in that: The essence comprises the composition according to claim 1.
10. The essence according to claim 9, characterized in that The essence also includes hydroxyethyl urea, diglycerin, ectoine, allantoin, panthenol, sodium hyaluronate, milk thistle fruit extract, arginine, glyceryl glucoside, PEG-12 polydimethylsiloxane crosspolymer, 3-o-ethyl ascorbic acid, PEG / PPG-14 / 7 dimethyl ether, carbomer, ammonium acryloyldimethyltaurate / VP copolymer, p-hydroxyacetophenone, and 1,2-hexanediol.