Cosmetic delivery system active composition and preparation method thereof

Abstract

The invention is suitable for the technical field of cosmetic transdermal delivery transmission systems, and provides an active composition of a cosmetic transmission system and a preparation method. The active composition is prepared from the following components in percentage content: 3 to 9 percent of decapeptide-4, 1 to 4 percent of isosorbide dimethyl ether, 2 to 5 percent of beta carotene, 1.8 to 2.8 percent of meadowfoam seed oil, 3.2 to 6.8 percent of yeast protein, 0.8 to 1.4 percent of cetostearyl alcohol, 3 to 7 percent of nymphaea caerulea powder, 1 to 2.5 percent of dipotassium glycyrrhizinate, 1.6 to 3.4 percent of emulsifier, 1.4 to 2.3 percent of penetration enhancer and the balance of nano emulsion. Preferably, the emulsifying agent is glycerol monocaprylate and / or glycerol monolaurate; preferably, the penetration enhancer is one of menthol, ethanol and azone. The active composition prepared by the invention not only has a skin care effect, but also contains effective components with medical effects, and through detection, the transdermal infiltration capacity of the active composition is good, and the active components can be favorably absorbed by the skin.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetic transdermal drug delivery systems, in particular to an active composition of a cosmetic delivery system and a preparation method thereof. Background Art

[0002] With the rapid development of science and technology and society, people's living standards are improving day by day, and people's demand for cosmetics is also growing. People pay more attention to care, and health and beauty have become one of their goals. As a result, people are no longer satisfied with the beauty effects of traditional cosmetics, but begin to pursue both health care and beauty. Therefore, new functional cosmetics that are different from traditional cosmetics and have some pharmaceutical functions have begun to appear.

[0003] Functional cosmetics, as the name implies, are cosmetics with certain functions and effects. The substances that can bring about the effects are active substances. Whether the active substances can be completely absorbed is related to the effect of the cosmetics. In this regard, the present invention proposes an active composition of a cosmetic delivery system and a preparation method. Summary of the invention

[0004] The object of the present invention is to provide an active composition of a cosmetic delivery system and a preparation method thereof, so as to solve the problems in the above-mentioned background technology.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: In a first aspect, the present invention provides an active composition of a cosmetic delivery system, wherein the components and percentage contents of the active composition are as follows:

[0006] 3-9% decapeptide-4, 1-4% dimethyl isosorbide, 2-5% beta-carotene, 1.8-2.8% meadowfoam seed oil, 3.2-6.8% yeast protein, 0.8-1.4% cetearyl alcohol, 3-7% blue water lily powder, 1-2.5% dipotassium glycyrrhizate, 1.6-3.4% emulsifier, 1.4-2.3% penetration enhancer, and the balance is nanoemulsion.

[0007] Preferably, the emulsifier is glyceryl monocaprylate and / or glyceryl monolaurate.

[0008] Preferably, the penetration enhancer is one of menthol, ethanol and azone.

[0009] Preferably, the nanoemulsion is resveratrol nanoemulsion and / or ceramide nanoemulsion.

[0010] Preferably, the mass fraction of the resveratrol nanoemulsion is 15%, and the mass fraction of the ceramide nanoemulsion is 20%.

[0011] The second invention of the present invention provides a method for preparing the active composition of the first aspect of the present invention, comprising the following steps:

[0012] S1, weigh decapeptide-4, β-carotene, yeast protein, and blue water lily powder, mix and grind for 15 min to 30 min;

[0013] S2, prepare the nanoemulsion in advance, then pour the mixture ground in S1 and the remaining components into a high-speed mixer, stir at 2000-3000 rpm / min for 15-25 min, vacuum fill, and seal for storage.

[0014] The present invention has at least the following beneficial effects:

[0015] The present invention provides an active composition of a cosmetic delivery system and a preparation method. The prepared active composition not only has a skin care effect, but also contains effective ingredients with medical effects. According to tests, it has good transdermal penetration ability and can help the skin absorb the effective ingredients. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a comparison chart of the transepidermal water loss test values ​​of the present invention. DETAILED DESCRIPTION

[0017] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0018] Example 1

[0019] A cosmetic delivery system active composition, the components and percentage contents of the active composition are as follows:

[0020] 3% decapeptide-4, 1% dimethyl isosorbide, 2% beta-carotene, 1.8% meadowfoam seed oil, 3.2% yeast protein, 0.8% cetearyl alcohol, 3% blue water lily powder, 1% dipotassium glycyrrhizate, 1.6% emulsifier, 1.4% penetration enhancer, and the balance is nanoemulsion.

[0021] The emulsifier is glyceryl monocaprylate; the penetration enhancer is menthol; the nanoemulsion is resveratrol nanoemulsion, and the mass fraction of the resveratrol nanoemulsion is 15%.

[0022] The preparation method of the above active composition comprises the following steps:

[0023] S1, weigh decapeptide-4, β-carotene, yeast protein, and blue water lily powder, mix and grind for 15 min;

[0024] S2, prepare the nanoemulsion in advance, then pour the mixture ground in S1 and the remaining components into a high-speed mixer, stir at 2000 rpm / min for 25 min, vacuum fill, and seal for storage.

[0025] Example 2

[0026] A cosmetic delivery system active composition, the components and percentage contents of the active composition are as follows:

[0027] 6% decapeptide-4, 2% dimethyl isosorbide, 4% beta-carotene, 2.5% meadowfoam seed oil, 5.4% yeast protein, 1% cetearyl alcohol, 6% blue water lily powder, 1.7% dipotassium glycyrrhizate, 2.1% emulsifier, 2% penetration enhancer, and the balance is nanoemulsion.

[0028] The emulsifier is glyceryl monolaurate; the penetration enhancer is ethanol; the nanoemulsion is ceramide nanoemulsion, and the mass fraction of ceramide nanoemulsion is 20%.

[0029] The preparation method of the above active composition comprises the following steps:

[0030] S1, weigh decapeptide-4, β-carotene, yeast protein, and blue water lily powder, mix and grind for 20 min;

[0031] S2, prepare the nanoemulsion in advance, then pour the mixture ground in S1 and the remaining components into a high-speed mixer, stir at 2500 rpm / min for 20 min, vacuum fill, and seal for storage.

[0032] Example 3

[0033] A cosmetic delivery system active composition, the components and percentage contents of the active composition are as follows:

[0034] 9% decapeptide-4, 4% dimethyl isosorbide, 5% beta-carotene, 2.8% meadowfoam seed oil, 6.8% yeast protein, 1.4% cetearyl alcohol, 7% blue water lily powder, 2.5% dipotassium glycyrrhizate, 3.4% emulsifier, 2.3% penetration enhancer, and the balance is nanoemulsion.

[0035] Among them, the emulsifiers are glyceryl monocaprylate and glyceryl monolaurate, and the mass ratio of glyceryl monocaprylate to glyceryl monolaurate is 3:1; the penetration enhancer is azone; the nanoemulsions are resveratrol nanoemulsion and ceramide nanoemulsion, and the mass ratio of resveratrol nanoemulsion to ceramide nanoemulsion is 1:2, the mass fraction of resveratrol nanoemulsion is 15%, and the mass fraction of ceramide nanoemulsion is 20%.

[0036] The preparation method of the above active composition comprises the following steps:

[0037] S1, weigh decapeptide-4, β-carotene, yeast protein, and blue water lily powder, mix and grind for 30 min;

[0038] S2, prepare the nanoemulsion in advance, then pour the mixture ground in S1 and the remaining components into a high-speed mixer, stir at 3000 rpm / min for 15 minutes, vacuum fill, and seal for storage.

[0039] The active composition prepared in the above example was subjected to a transdermal penetration test. After about 20 minutes, the effective ingredients of the active composition penetrated to a maximum depth of 20 μm.

[0040] The present invention realizes efficient transdermal transmission of effective ingredients in cosmetics through a specific active composition ratio and preparation process. Among them, decapeptide-4, as an important bioactive peptide, has significant skin repair and anti-aging functions; dimethyl isosorbide is used as a penetration enhancer, which can effectively improve the skin's absorption efficiency of active substances; beta-carotene, white meadowfoam seed oil, yeast protein and other ingredients provide rich nutrition and moisturizing effects, which help to improve skin conditions; blue water lily powder, dipotassium glycyrrhizate and other ingredients have soothing and anti-inflammatory effects, which can relieve skin discomfort; and the selection of emulsifiers and penetration enhancers further optimizes the stability and permeability of the active composition.

[0041] The active composition of the cosmetic delivery system of the present invention can be widely used in various functional cosmetics, such as anti-wrinkle, whitening, moisturizing, repairing, etc. At the same time, since the active composition prepared by the present invention has excellent transdermal penetration ability and skin absorption efficiency, it can significantly improve the use effect of cosmetics and meet consumers' demand for efficient, safe and healthy cosmetics.

[0042] The product obtained in Example 2 was subjected to a series of tests as follows:

[0043] 1. Purpose of testing:

[0044] A 24-hour closed patch test was performed on 33 subjects according to the prescribed procedures to verify whether the product prepared in Example 2 has the potential to cause adverse skin reactions.

[0045] 33 subjects were selected after the lactic acid stimulation test according to the prescribed procedures to test the samples, and the transepidermal water loss of the subjects before and after the test samples was detected by instruments to verify whether the product prepared in Example 2 has a repair effect, and a comprehensive evaluation was performed.

[0046] 2. Test results:

[0047] 1. 24-hour closed patch test on human skin:

[0048] 1.1 Materials and methods

[0049] 1) Test sample: the product prepared in Example 2.

[0050] 2) Negative control: blank control.

[0051] 3) Subjects: A total of 33 subjects, including 11 males and 22 females, aged 24 to 51 years old, with an average age of 36.5±6.2 years old, met the voluntary inclusion criteria.

[0052] 4) Patch test method: Select qualified patch test equipment and use the occluded patch test method. Place about 0.020g to 0.025g of the test sample in the patch tester and apply it to the curved side of the subject's forearm with a low-allergenic tape. Remove the test sample after 24 hours and observe the skin reaction 0.5 hour after removal. Record the results according to the skin reaction grading standards in LABC-WI-HZ-033 "Operation Guide for 24-Hour Occluded Patch Test on Human Skin".

[0053] 1.2 Test results

[0054]

[0055] 1.3 Test conclusion

[0056] The results of human skin patch tests showed that no adverse reactions were observed among 33 people, and the test samples had no potential to cause adverse skin reactions.

[0057] 2. Repair efficacy evaluation test results

[0058] 2.1 Transepidermal water loss

[0059] 2.1.1 Improvement rate

[0060] project Base value (D0) Use the product for 28 days (D28) Measurement value (mean ± standard deviation) 13.51±3.40 12.41±3.01 Improvement rate (%) - 7.45

[0061] Note: The improvement rate is the improvement rate relative to the rate before use, and the calculation formula is as follows:

[0062]

[0063] Where: D 0 The basic values ​​of skin parameters before using the samples on the test area;

[0064] Dt is the skin parameter value after the sample t (D) is used on the test area;

[0065] N is the effective number of subjects.

[0066] 2.1.2 Statistical analysis and determination results of transepidermal water loss test values

[0067]

[0068] Remark:

[0069] a: After subtracting the baseline value D0 from the D28 measurement value, the data obtained were subjected to the Shapiro-Wilk test using SPSS software;

[0070] b: If the asymptotic significance value of the normality test is P>0.05, the data series follows a normal distribution;

[0071] c: If the test data results conform to the normal distribution, the comparison before and after itself (D28 measurement value and basic value D0) is carried out by paired sample t test;

[0072] If it does not conform to the normal distribution, the D28 measurement value and the basic value D0 are subjected to two related sample rank sum tests; the statistical method adopts a two-tailed test, and the significance level is α = 0.05;

[0073] d: If the statistical method significance level P < 0.05, it indicates that there is a statistically significant difference between the subjects before and after using the sample;

[0074] If the statistical method significance level P ≥ 0.05, it indicates that there is no statistically significant difference between the subjects before and after using the sample.

[0075] Figure 1 Comparison chart of transepidermal water loss test values

[0076] 2.1.3 Conclusion

[0077] After using product D28, compared with the basic value D0, the value of transepidermal water loss of the skin was significantly different (P < 0.05), and the improvement rate of transepidermal water loss of the skin was 7.45%. The test sample had a significant effect on slowing down the loss of skin water.

[0078] Conclusion Explanation:

[0079] The numerical test results of transepidermal water loss of the test sample D28 were compared with the basic value D0. If the numerical test result of transepidermal water loss of D28 was better (lower) than D0 and the statistical difference P value was <0.05, it means that the test sample has the effect of repairing the skin and slowing down the loss of skin water, otherwise there is no effective improvement.

[0080] The above shows and describes the basic principles, main features and advantages of the present invention. It is obvious to those skilled in the art that the present invention is not limited to the details of the above exemplary embodiments, and that the present invention can be implemented in other specific forms without departing from the spirit or basic features of the present invention. Therefore, no matter from which point of view, the embodiments should be regarded as exemplary and non-restrictive. The scope of the present invention is defined by the appended claims rather than the above description, and it is intended that all changes falling within the meaning and scope of the equivalent elements of the claims are included in the present invention.

[0081] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A cosmetic delivery system active composition, characterized in that: The components and percentage contents of the active composition are as follows: 3-9% decapeptide-4, 1-4% dimethyl isosorbide, 2-5% beta-carotene, 1.8-2.8% meadowfoam seed oil, 3.2-6.8% yeast protein, 0.8-1.4% cetearyl alcohol, 3-7% blue water lily powder, 1-2.5% dipotassium glycyrrhizate, 1.6-3.4% emulsifier, 1.4-2.3% penetration enhancer, and the balance is nanoemulsion.

2. A cosmetic delivery system active composition and preparation method according to claim 1, characterized in that: The emulsifier is glyceryl monocaprylate and / or glyceryl monolaurate.

3. A cosmetic delivery system active composition and preparation method according to claim 1, characterized in that: The penetration enhancer is one of menthol, ethanol and azone.

4. A cosmetic delivery system active composition and preparation method according to claim 1, characterized in that: The nanoemulsion is resveratrol nanoemulsion and / or ceramide nanoemulsion.

5. A cosmetic delivery system active composition and preparation method according to claim 4, characterized in that: The mass fraction of the resveratrol nanoemulsion is 15%, and the mass fraction of the ceramide nanoemulsion is 20%.

6. The method for preparing the active composition according to any one of claims 1 to 5, characterized in that: The following steps are involved: S1, weigh decapeptide-4, β-carotene, yeast protein, and blue water lily powder, mix and grind for 15 min to 30 min; S2, prepare the nanoemulsion in advance, then pour the mixture ground in S1 and the remaining components into a high-speed mixer, stir at 2000-3000 rpm / min for 15-25 min, vacuum fill, and seal for storage.

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