Acne removal composition as well as preparation method and application thereof

Abstract

The invention relates to an acne-removing composition as well as a preparation method and application thereof, and belongs to the technical field of cosmetics. The acne-removing composition is prepared from the following components: amur corktree bark extract, herba houttuyniae extract, mango leaf extract, radix cynanchi atrati extract, licochalcone A, functional particles and hydroxyl pinacolone retinoate. According to the preparation method, phenolic hydroxyl groups of honokiol and carboxyl groups of ferulic acid are subjected to esterification reaction, so that the stability of honokiol modified ferulic acid is improved, then nicotinamide and xylose are used as wall materials to coat the honokiol modified ferulic acid, and the stability of the honokiol modified ferulic acid is further enhanced; the introduced Schiff base structure can effectively remove free radicals in the skin and reduce pigmentation.

Description

Technical Field

[0001] The invention belongs to the technical field of cosmetics and relates to an anti-acne composition and a preparation method and application thereof. Background Art

[0002] Acne, commonly known as pimples, is one of the most common skin diseases in adolescence. Its main cause is excessive oil secretion from the sebaceous glands, coupled with abnormal keratinization of the hair follicles, which leads to blocked pores and bacterial proliferation, thus causing inflammation. During adolescence, due to the increase in hormone levels in the body, especially male hormones, the activity of the sebaceous glands intensifies, making teenagers more susceptible to acne. In addition, factors such as genetics, eating habits, lifestyle and psychological stress are also key factors in inducing acne.

[0003] Hydroxypinacolone retinoic acid ester is a widely used ingredient in skin care products. Its function is to promote the repair and regeneration of skin cells, inhibit melanin synthesis, and improve skin color. However, if used improperly, it may cause skin irritation or allergic reactions.

[0004] As a natural organic compound, ferulic acid has received extensive attention in the field of acne treatment in recent years. It has multiple biological activities such as antioxidant, anti-inflammatory and antibacterial, making it a potential application value in skin care products. However, due to its structural characteristics of carboxyl, phenolic hydroxyl, double bonds and short alkyl chains, ferulic acid has poor stability and is easily oxidized in light and air, thereby reducing its efficacy. Secondly, the absorption rate of ferulic acid is low, making it difficult to play a role in the deep layers of the skin. Summary of the invention

[0005] The purpose of the present invention is to provide an acne-removing composition, a preparation method and application thereof. The phenolic hydroxyl group of honokiol is reacted with the carboxyl group of ferulic acid to form an esterification reaction, thereby improving the stability of the ferulic acid modified with honokiol. Subsequently, nicotinamide and xylose are used as wall materials to coat the honokiol-modified ferulic acid to further enhance its stability. The introduced Schiff base structure can effectively remove free radicals in the skin and reduce pigmentation.

[0006] The purpose of the present invention can be achieved through the following technical solutions:

[0007] An acne-removing composition comprises the following components by weight:

[0008]

[0009] As a preferred technical solution of the present invention, the mechanism of action of ferulic acid in anti-acne products is mainly based on its ability to resist oxidation, inhibit tyrosinase activity and protect the skin from ultraviolet damage.

[0010] As a preferred technical solution of the present invention, the licorice chalcone A is derived from the root extract of Glycyrrhiza inflata, and licorice chalcone A achieves soothing and moisturizing effects by inhibiting the activity of hyaluronidase.

[0011] As a preferred technical solution of the present invention, the main active ingredient contained in the Phellodendron bark extract is berberine, which has antioxidant properties and can help remove free radicals and protect the skin from oxidative stress damage. In addition, the Phellodendron bark extract may also assist in removing the formed melanin deposits by promoting the metabolism of skin cells, thereby achieving the effect of improving the health of the skin.

[0012] As a preferred technical solution of the present invention, the alkaloids in the white osmanthus extract can inhibit the activity of tyrosinase, which is a key enzyme involved in the synthesis of melanin. By inhibiting its activity, the production of melanin can be reduced. In addition, other components in the white osmanthus extract, such as polyphenol compounds, may also help reduce oxidative stress in the skin through antioxidant effects and improve the health of the skin.

[0013] The present invention discloses a method for preparing the functional particles, comprising the following steps:

[0014] S1. In a light-proof atmosphere, honokiol and anhydrous ethanol are placed in a reaction kettle and stirred and mixed, a catalyst is added to cool the mixture, ferulic acid is added, stirring is continued, and centrifugation is performed, the supernatant is removed, and freeze-drying is performed to obtain composite particles;

[0015] S2. The composite particles and nicotinamide solution are placed in a reactor for mechanical mixing and then preheated. After adding xylose and heat preservation, the supernatant is removed by centrifugation, and the functional particles are obtained after washing with water and freeze-drying.

[0016] As a preferred technical solution of the present invention, in step S1, the stirring and mixing is stirring at a rotation speed of 200-300 r / min for 14-20 min.

[0017] As a preferred technical solution of the present invention, in step S1, the cooling treatment is cooling to a temperature of 5-6°C.

[0018] As a preferred technical solution of the present invention, in step S1, the mass ratio of honokiol, anhydrous ethanol, catalyst and ferulic acid is 1.4-1.8:15-20:1.50-1.62:1.2-1.4.

[0019] As a preferred technical solution of the present invention, in step S1, the catalyst is prepared by mixing DCC and DMAP in a mass ratio of 2:1.

[0020] As a preferred technical solution of the present invention, in step S2, the mechanical mixing is stirring at a rotation speed of 300-400 r / min for 20-30 min.

[0021] As a preferred technical solution of the present invention, in step S2, the preheating temperature is 40-50°C.

[0022] As a preferred technical solution of the present invention, in step S2, the heat preservation treatment is stirring at a speed of 500-600 r / min and a temperature of 60-70° C. for 4-5 hours.

[0023] As a preferred technical solution of the present invention, in step S2, the water washing is performed by washing with deionized water for 3 times.

[0024] As a preferred technical solution of the present invention, in step S2, the mass ratio of the composite particles, nicotinamide solution and xylose is 13-18:30-32:5-8.

[0025] As a preferred technical solution of the present invention, in step S2, the nicotinamide solution is prepared by mixing nicotinamide and 50% by mass ethanol aqueous solution in a mass ratio of 2-3:18-24.

[0026] As a preferred technical solution of the present invention, an anti-acne composition further comprises the following components by weight:

[0027]

[0028] As a preferred technical solution of the present invention, the penetration enhancer is methyl propanediol.

[0029] As a preferred technical solution of the present invention, the moisturizing agent is one or more of betaine, glycerin, erythritol, xylitol, glyceryl polyether-5 lactate and sodium polyglutamate.

[0030] As a preferred technical solution of the present invention, the conditioning agent is one or more of panthenol, beeswax and salicylic acid.

[0031] As a preferred technical solution of the present invention, the thickener is carbomer.

[0032] The present invention discloses a method for preparing an acne-removing composition, which comprises the following steps:

[0033] 1) heating deionized water to 40-50° C., adding Phellodendron amurense bark extract, Houttuynia cordata extract, mango leaf extract, Psoralea corylifolia extract, Licorice chalcone A, hydroxypinacolone retinoic acid ester, penetration enhancer, moisturizer and conditioner, mixing evenly, and stirring for 45-60 minutes to obtain a mixed solution;

[0034] 2) Cool the mixed solution to 30-40° C., add the functional particles and thickener, stir at 1200-1500 r / min for 40-60 min, and cool to room temperature to obtain the product.

[0035] A use of the above acne-removing composition in cosmetics.

[0036] Beneficial effects of the present invention:

[0037] The phenolic hydroxyl group of honokiol and the carboxyl group of ferulic acid are reacted for esterification to improve the stability of honokiol-modified ferulic acid. Then, niacinamide and xylose are used as wall materials to coat the honokiol-modified ferulic acid to further enhance its stability. The introduced Schiff base structure can effectively remove free radicals in the skin and reduce pigmentation. DETAILED DESCRIPTION

[0038] In order to further illustrate the technical means and effects adopted by the present invention to achieve the predetermined invention purpose, the specific implementation methods, structures, features and effects of the present invention are described in detail below in combination with the embodiments.

[0039] Example 1

[0040] An anti-acne composition comprises the following components by weight:

[0041]

[0042] The penetration enhancer is methylpropanediol; the moisturizer is betaine; and the conditioning agent is panthenol.

[0043] The method for preparing the functional particles comprises the following steps:

[0044] S1. In a light-proof atmosphere, honokiol and anhydrous ethanol are placed in a reaction kettle and stirred and mixed, a catalyst is added to cool the mixture, ferulic acid is added, stirring is continued, and centrifugation is performed, the supernatant is removed, and freeze-drying is performed to obtain composite particles;

[0045] S2. The composite particles and nicotinamide solution are placed in a reactor for mechanical mixing and then preheated. After adding xylose and heat preservation, the supernatant is removed by centrifugation, and the functional particles are obtained after washing with water and freeze-drying.

[0046] In step S1, the stirring and mixing is stirring at a speed of 200 r / min for 14 minutes; the cooling treatment is cooling to 5°C; the mass ratio of honokiol, anhydrous ethanol, catalyst and ferulic acid is 1.4:15:1.50:1.2; the catalyst is a mixture of DCC and DMAP in a mass ratio of 2:1;

[0047] In step S2, the mechanical mixing is stirring at a speed of 300 r / min for 20 min; the preheating temperature is 40° C.; the heat preservation treatment is stirring at a speed of 500 r / min and a temperature of 60° C. for 4 h; the water washing is washing with deionized water for 3 times; the mass ratio of the composite particles, nicotinamide solution and xylose is 13:30:5; the nicotinamide solution is prepared by mixing nicotinamide and a 50% by mass ethanol aqueous solution in a mass ratio of 2:18;

[0048] A method for preparing an anti-acne composition comprises the following steps:

[0049] 1) Heat deionized water to 40° C., add Phellodendron amurense bark extract, Houttuynia cordata extract, mango leaf extract, Psoralea corylifolia extract, Licorice chalcone A, hydroxypinacolone retinoic acid ester, penetration enhancer, moisturizer and conditioner, mix well, and stir for 45 minutes to obtain a mixed solution;

[0050] 2) Cool the mixed solution to 30° C., add the functional particles and thickener, stir at 1200 r / min for 40 min, and cool to room temperature to obtain the product.

[0051] Example 2

[0052] An anti-acne composition comprises the following components by weight:

[0053]

[0054]

[0055] The penetration enhancer is methylpropanediol; the moisturizer is betaine; and the conditioning agent is panthenol.

[0056] The method for preparing the functional particles comprises the following steps:

[0057] S1. In a light-proof atmosphere, honokiol and anhydrous ethanol are placed in a reaction kettle and stirred and mixed, a catalyst is added to cool the mixture, ferulic acid is added, stirring is continued, and centrifugation is performed, the supernatant is removed, and freeze-drying is performed to obtain composite particles;

[0058] S2. The composite particles and nicotinamide solution are placed in a reactor for mechanical mixing and then preheated. After adding xylose and heat preservation, the supernatant is removed by centrifugation, and the functional particles are obtained after washing with water and freeze-drying.

[0059] In step S1, the stirring and mixing is stirring at a speed of 225 r / min for 16 minutes; the cooling treatment is cooling to a temperature of 5.2° C.; the mass ratio of honokiol, anhydrous ethanol, catalyst and ferulic acid is 1.5:16:1.53:1.25; the catalyst is a mixture of DCC and DMAP in a mass ratio of 2:1;

[0060] In step S2, the mechanical mixing is stirring at a speed of 325 r / min for 22 minutes; the preheating temperature is 42°C; the heat preservation treatment is stirring at a speed of 525 r / min and a temperature of 62°C for 4.2 hours; the water washing is washing with deionized water for 3 times; the mass ratio of the composite particles, nicotinamide solution and xylose is 14:30.5:5.8; the nicotinamide solution is prepared by mixing nicotinamide and 50% by mass ethanol aqueous solution in a mass ratio of 2.2:20;

[0061] A method for preparing an anti-acne composition comprises the following steps:

[0062] 1) Heat deionized water to 42° C., add Phellodendron amurense bark extract, Houttuynia cordata extract, mango leaf extract, Psoralea corylifolia extract, Licorice chalcone A, hydroxypinacolone retinoic acid ester, penetration enhancer, moisturizer and conditioner, mix well, and stir for 49 minutes to obtain a mixed solution;

[0063] 2) Cool the mixed solution to 32° C., add the functional particles and thickener, stir at 1275 r / min for 45 min, and cool to room temperature to obtain the product.

[0064] Example 3

[0065] An anti-acne composition comprises the following components by weight:

[0066]

[0067] The penetration enhancer is methylpropanediol; the moisturizer is betaine; and the conditioning agent is panthenol.

[0068] The method for preparing the functional particles comprises the following steps:

[0069] S1. In a light-proof atmosphere, honokiol and anhydrous ethanol are placed in a reaction kettle and stirred and mixed, a catalyst is added to cool the mixture, ferulic acid is added, stirring is continued, and centrifugation is performed, the supernatant is removed, and freeze-drying is performed to obtain composite particles;

[0070] S2. The composite particles and nicotinamide solution are placed in a reactor for mechanical mixing and then preheated. After adding xylose and heat preservation, the supernatant is removed by centrifugation, and the functional particles are obtained after washing with water and freeze-drying.

[0071] In step S1, the stirring and mixing is stirring at a speed of 250 r / min for 17 minutes; the cooling treatment is cooling to a temperature of 5.5°C; the mass ratio of honokiol, anhydrous ethanol, catalyst and ferulic acid is 1.6:18:1.56:1.3; the catalyst is a mixture of DCC and DMAP in a mass ratio of 2:1;

[0072] In step S2, the mechanical mixing is stirring at a speed of 350 r / min for 25 minutes; the preheating temperature is 45°C; the heat preservation treatment is stirring at a speed of 550 r / min and a temperature of 65°C for 4.5 hours; the water washing is washing with deionized water for 3 times; the mass ratio of the composite particles, nicotinamide solution and xylose is 16:31:6.5; the nicotinamide solution is prepared by mixing nicotinamide and 50% by mass ethanol aqueous solution in a mass ratio of 2.5:21;

[0073] A method for preparing an anti-acne composition comprises the following steps:

[0074] 1) Heat deionized water to 45° C., add Phellodendron amurense bark extract, Houttuynia cordata extract, mango leaf extract, Phellodendron chinense extract, Licorice chalcone A, hydroxypinacolone retinoic acid ester, penetration enhancer, moisturizer and conditioner, mix well, and stir for 52 minutes to obtain a mixed solution;

[0075] 2) Cool the mixed solution to 35°C, add the functional particles and thickener, stir at 1350 r / min for 50 min, and cool to room temperature to obtain the product.

[0076] Example 4

[0077] An anti-acne composition comprises the following components by weight:

[0078]

[0079]

[0080] The penetration enhancer is methylpropanediol; the moisturizer is betaine; and the conditioning agent is panthenol.

[0081] The method for preparing the functional particles comprises the following steps:

[0082] S1. In a light-proof atmosphere, honokiol and anhydrous ethanol are placed in a reaction kettle and stirred and mixed, a catalyst is added to cool the mixture, ferulic acid is added, stirring is continued, and centrifugation is performed, the supernatant is removed, and freeze-drying is performed to obtain composite particles;

[0083] S2. The composite particles and nicotinamide solution are placed in a reactor for mechanical mixing and then preheated. After adding xylose and heat preservation, the supernatant is removed by centrifugation, and the functional particles are obtained after washing with water and freeze-drying.

[0084] In step S1, the stirring and mixing is stirring at a speed of 275 r / min for 18 minutes; the cooling treatment is cooling to a temperature of 5.8°C; the mass ratio of honokiol, anhydrous ethanol, catalyst and ferulic acid is 1.7:19:1.59:1.35; the catalyst is a mixture of DCC and DMAP in a mass ratio of 2:1;

[0085] In step S2, the mechanical mixing is stirring at a speed of 375 r / min for 28 minutes; the preheating temperature is 48°C; the heat preservation treatment is stirring at a speed of 575 r / min and a temperature of 68°C for 4.8 hours; the water washing is washing with deionized water for 3 times; the mass ratio of the composite particles, nicotinamide solution and xylose is 17:31.5:7; the nicotinamide solution is prepared by mixing nicotinamide and 50% by mass ethanol aqueous solution in a mass ratio of 2.8:22;

[0086] A method for preparing an anti-acne composition comprises the following steps:

[0087] 1) Deionized water was heated to 48° C., and the extract of Phellodendron amurense bark, Houttuynia cordata extract, mango leaf extract, Psoralea corylifolia extract, Licorice chalcone A, hydroxypinacolone retinoic acid ester, a penetration enhancer, a moisturizer and a conditioning agent were added and mixed evenly, and stirred for 56 minutes to obtain a mixed solution;

[0088] 2) Cool the mixed solution to 38° C., add the functional particles and thickener, stir at 1425 r / min for 55 min, and cool to room temperature to obtain the product.

[0089] Example 5

[0090] An anti-acne composition comprises the following components by weight:

[0091]

[0092] The penetration enhancer is methylpropanediol; the moisturizer is betaine; and the conditioning agent is panthenol.

[0093] The method for preparing the functional particles comprises the following steps:

[0094] S1. In a light-proof atmosphere, honokiol and anhydrous ethanol are placed in a reaction kettle and stirred and mixed, a catalyst is added to cool the mixture, ferulic acid is added, stirring is continued, and centrifugation is performed, the supernatant is removed, and freeze-drying is performed to obtain composite particles;

[0095] S2. The composite particles and nicotinamide solution are placed in a reactor for mechanical mixing and then preheated. After adding xylose and heat preservation, the supernatant is removed by centrifugation, and the functional particles are obtained after washing with water and freeze-drying.

[0096] In step S1, the stirring and mixing is stirring at a speed of 300 r / min for 20 minutes; the cooling treatment is cooling to 6°C; the mass ratio of honokiol, anhydrous ethanol, catalyst and ferulic acid is 1.8:20:1.62:1.4; the catalyst is a mixture of DCC and DMAP in a mass ratio of 2:1;

[0097] In step S2, the mechanical mixing is stirring at a speed of 400 r / min for 30 minutes; the preheating temperature is 50° C.; the heat preservation treatment is stirring at a speed of 600 r / min and a temperature of 70° C. for 5 hours; the water washing is washing with deionized water for 3 times; the mass ratio of the composite particles, nicotinamide solution and xylose is 18:32:8; the nicotinamide solution is prepared by mixing nicotinamide and 50% by mass ethanol aqueous solution in a mass ratio of 3:24;

[0098] A method for preparing an anti-acne composition comprises the following steps:

[0099] 1) Heat deionized water to 50° C., add Phellodendron amurense bark extract, Houttuynia cordata extract, mango leaf extract, Psoralea corylifolia extract, Licorice chalcone A, hydroxypinacolone retinoic acid ester, penetration enhancer, moisturizer and conditioner, mix well, and stir for 60 minutes to obtain a mixed solution;

[0100] 2) Cool the mixed solution to 40° C., add the functional particles and thickener, stir at 1500 r / min for 60 min, and cool to room temperature to obtain the product.

[0101] Comparative Example 1

[0102] Compared with Example 4, the difference is that honokiol is not added, and the other components, preparation steps and parameters are the same.

[0103] Comparative Example 2

[0104] Compared with Example 4, the difference is that ferulic acid is not added, and the other components, preparation steps and parameters are the same.

[0105] Comparative Example 3

[0106] Compared with Example 4, the difference is that nicotinamide solution is not added, and anhydrous ethanol is used instead, and the other components, preparation steps and parameters are the same.

[0107] Comparative Example 4

[0108] Compared with Example 4, the difference is that xylose is not added, and the other components, preparation steps and parameters are the same.

[0109] Comparative Examples 5-7

[0110] Compared with Example 4, the difference is that the weight ratios of the Bletilla striata extract, licorice chalcone A and hydroxypinacolone retinoic acid ester are as shown in Table 1, and the other components, preparation steps and parameters are the same.

[0111] Table 1 (Unit: parts by weight)

[0112] White Rose Extract Licochalcone A Hydroxypinacolone retinoate Example 4 6 1.2 2 Comparative Example 5 0 4.2 5 Comparative Example 6 6.6 0 2.6 Comparative Example 7 7 2.2 0

[0113] Comparative Example 8

[0114] Compared with Example 4, the difference is that 8 parts of hydroxypinacolone retinoic acid ester are added, and the other components, preparation steps and parameters are the same.

[0115] Irritation evaluation test

[0116] 65 adult subjects with healthy skin were selected and divided into 13 groups, with 5 persons in each group, and the compositions prepared in Examples 1-5 and Comparative Examples 1-8 were tested accordingly, and the results were averaged.

[0117] Test method: After washing the face in the morning and evening, apply the composition prepared in each embodiment and comparative example on the left side, and the adult volunteers score the irritation of the composition after using it for 7 consecutive days, during which time no other skin care products are used;

[0118] The rating scale is 0-10, where 0 means no obvious irritation, 1-2 means slight irritation, 3-4 means strong irritation, 5-6 means moderate irritation, 7-8 means strong irritation, and 9-10 means severe irritation. The test results are shown in Table 2.

[0119] Table 2

[0120] Irritation rating Example 1 1.0 Example 2 0.8 Example 3 1.0 Example 4 0.8 Example 5 1.0 Comparative Example 1 0.8 Comparative Example 2 1.0 Comparative Example 3 0.8 Comparative Example 4 1.0 Comparative Example 5 2.0 Comparative Example 6 6.0 Comparative Example 7 0.6 Comparative Example 8 8.0

[0121] From the results in Table 2, combined with the analysis of Examples 1-5 and Comparative Examples 1-8, it can be seen that the combination of the Bletilla striata extract and Licorice Chalcone A can significantly reduce the skin irritation effect of hydroxypinacolone retinoic acid ester.

[0122] Cellular antioxidant efficacy evaluation experiment

[0123] First, a sample solution (Example 1-5, Comparative Example 1-8) with a concentration of 0.5% was prepared with serum-free DMEM culture medium, and sterilized by filtration with a 0.22 μm filter membrane. Then, a dichlorofluorescein diacetate (DCFH-DA) probe solution was prepared: diluting at a ratio of 0.375 uLDCFH-DA: 1 mL PBS.

[0124] HaCaT cells in the logarithmic growth phase were cultured at 1×10 5Cells were inoculated at a density of 100 cells / mL in a 24-well culture plate, and 15 wells were selected. Each well contained 2 mL of cell suspension and was placed in a carbon dioxide incubator at 37°C and 5% CO2 for 24 hours. 2 , irradiation intensity for 1h, UVB with 700μW / cm 2 The cells were irradiated with an intensity of 100 μg / mL for 3 min, and the normal control group was not irradiated. After irradiation, the old culture medium was discarded, and the sample solution was added to the experimental group, and serum-free DMEM culture medium was added to the model group and the normal control group, with 2 mL per well. After continuing to culture for 16 h, all the culture medium was discarded and washed twice with PBS. 1.5 mL of DCFH-DA solution was added to each well, and the cells were placed in a 37 ° C cell culture incubator for another 30 min, and mixed every 5 min to allow the probe to fully bind. The probe was discarded, washed twice with preheated serum-free culture medium, and 1 mL of serum-free culture medium was added to each well and incubated at 37 ° C for 10 min. After washing once with PBS, the cells were digested with trypsin, washed twice with PBS, resuspended with 300 μL PBS, and detected by dual-channel flow cytometer (cells were filtered with a 100-mesh filter before being put on the machine), FL1-H channel, and 10,000 cells were collected for each sample.

[0125] ROS clearance rate = (model group - experimental group) / model group × 100%;

[0126] The test results are shown in Table 3;

[0127] Table 3

[0128] DPPH free radical scavenging rate (%) ROS clearance rate (%) Example 1 92.2 87.4 Example 2 93.7 87.8 Example 3 92.4 86.7 Example 4 93.9 88.1 Example 5 93.6 88.1 Comparative Example 1 72.7 64.2 Comparative Example 2 73.1 65.3 Comparative Example 3 75.4 67.6 Comparative Example 4 75.6 66.8 Comparative Example 5 87.4 78.3 Comparative Example 6 78.8 70.2 Comparative Example 7 91.2 85.6 Comparative Example 8 90.4 83.9

[0129] It can be seen from the test results in Table 3 that compared with Comparative Examples 1-8, Examples 1-5 of the present invention modify ferulic acid with honokiol through an esterification reaction between the phenolic hydroxyl group of honokiol and the carboxyl group of ferulic acid. Honokiol has multiple benzene ring structures and has antioxidant properties, so that the stability of ferulic acid is improved. Then, niacinamide and xylose are used as wall materials to coat the honokiol-modified ferulic acid to further enhance its stability. The introduced Schiff base structure can effectively remove free radicals in the skin and reduce pigmentation.

[0130] The above description is only a preferred embodiment of the present invention and does not limit the present invention in any form. Although the present invention has been disclosed as a preferred embodiment as above, it is not used to limit the present invention. Any technical personnel in this field can make some changes or modify the technical contents disclosed above into equivalent embodiments without departing from the scope of the technical solution of the present invention. However, any brief modifications, equivalent changes and modifications made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention are still within the scope of the technical solution of the present invention.

Claims

1. An anti-acne composition, characterized in that: The components include the following by weight:

2. An anti-acne composition according to claim 1, characterized in that: The method for preparing the functional particles comprises the following steps: S1. In a light-proof atmosphere, honokiol and anhydrous ethanol are placed in a reaction kettle and stirred and mixed, a catalyst is added to cool the mixture, ferulic acid is added, stirring is continued, and centrifugation is performed, the supernatant is removed, and freeze-drying is performed to obtain composite particles; S2. The composite particles and nicotinamide solution are placed in a reactor for mechanical mixing and then preheated. After adding xylose and heat preservation, the supernatant is removed by centrifugation, and the functional particles are obtained after washing with water and freeze-drying.

3. An anti-acne composition according to claim 1, characterized in that: In step S1, the stirring and mixing is stirring at a speed of 200-300 r / min for 14-20 min; the cooling treatment is cooling to a temperature of 5-6°C.

4. The anti-acne composition according to claim 1, characterized in that: In step S1, the mass ratio of honokiol, anhydrous ethanol, catalyst and ferulic acid is 1.4-1.8:15-20:1.50-1.62:1.2-1.4; the catalyst is prepared by mixing DCC and DMAP in a mass ratio of 2:

1.

5. The anti-acne composition according to claim 1, characterized in that: In step S2, the mechanical mixing is stirring at a speed of 300-400 r / min for 20-30 min; the preheating temperature is 40-50°C; the heat preservation treatment is stirring at a speed of 500-600 r / min and a temperature of 60-70°C for 4-5 h; and the water washing is washing 3 times with deionized water.

6. The anti-acne composition according to claim 1, characterized in that: In step S2, the mass ratio of the composite particles, nicotinamide solution and xylose is 13-18:30-32:5-8; the nicotinamide solution is prepared by mixing nicotinamide and 50% by mass ethanol aqueous solution in a mass ratio of 2-3:18-24.

7. The anti-acne composition according to claim 1, characterized in that: The following components are also included by weight:

8. An anti-acne composition according to claim 7, characterized in that: The penetration enhancer is methylpropanediol; the moisturizer is one or more of betaine, glycerin, erythritol, xylitol, glyceryl polyether-5 lactate and sodium polyglutamate; and the conditioning agent is one or more of panthenol, beeswax and salicylic acid.

9. A method for preparing the anti-acne composition according to any one of claims 7 to 8, characterized in that: The preparation method comprises the following steps: 1) heating deionized water to 40-50° C., adding Phellodendron amurense bark extract, Houttuynia cordata extract, mango leaf extract, Psoralea corylifolia extract, Licorice chalcone A, hydroxypinacolone retinoic acid ester, penetration enhancer, moisturizer and conditioner, mixing evenly, and stirring for 45-60 minutes to obtain a mixed solution; 2) Cool the mixed solution to 30-40° C., add the functional particles and thickener, stir at 1200-1500 r / min for 40-60 min, and cool to room temperature to obtain the product.

10. Use of the anti-acne composition according to any one of claims 1 to 8 in cosmetics.

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