Chinese herbal medicine acne-removing composition and preparation method thereof

Abstract

The invention discloses a Chinese herbal medicine acne-removing composition and a preparation method thereof, and the Chinese herbal medicine acne-removing composition comprises the following components in percentage by mass: 5-15% of a humectant, 5-20% of a cortex phellodendri extract, 5-20% of a coptis chinensis extract, 0.1-1% of allantoin, 0.05-0.3% of dipotassium glycyrrhizinate, 0.5-4% of a skin conditioner, 0.5-2% of a preservative, 0.2-0.8% of a thickener and 0.1-5% of an auxiliary material, the sum of the mass fractions of the components does not exceed 100%, and the balance is filler. The acne-removing mask has the effects of regulating reproduction of pathogenic bacteria such as propionibacterium acnes and staphylococcus aureus to remove acnes, and has multiple effects of moisturizing, relieving, removing acnes and the like.

Description

Technical Field

[0001] The invention relates to the field of cosmetics, and in particular to a Chinese herbal medicine acne-removing composition and a preparation method thereof. Background Art

[0002] Acne is a common skin disease in adolescence that causes chronic inflammation of the hair follicles and sebaceous glands. Endocrine disorders and excessive secretion of male hormones lead to vigorous oil secretion and abnormal keratinization of the hair follicles and sebaceous gland ducts. Propionibacterium acnes plays a major role in the occurrence of acne and is the main pathogenic bacteria of acne. It also causes a variety of pro-inflammatory factors and chemokines to drive inflammatory responses. Staphylococcus aureus and epidermal Staphylococcus flora are also frequently studied flora in the pathogenesis of acne. They aggravate the occurrence of acne to varying degrees. It causes local redness and swelling on the face, and even ulceration in severe cases, leaving scars on the patient, thus affecting their psychological growth.

[0003] There are many kinds of raw materials for acne removal products on the market, but most of them focus on exfoliation and oil control effects. Their effect in inhibiting major pathogenic bacteria is not good. To address the above problems, it is necessary to find a complex that can reduce the risk of pathogenic bacteria infection, promote skin regeneration, and control local skin inflammation. Summary of the invention

[0004] In view of the problems of existing Chinese herbal acne-removing compositions, the present invention proposes a Chinese herbal acne-removing composition and a preparation method thereof. The Chinese herbal acne-removing composition has the effect of regulating the reproduction of pathogenic bacteria such as Propionibacterium acnes and Staphylococcus aureus on the skin to achieve the effect of removing acne, and has multiple functions such as moisturizing, soothing and removing acne.

[0005] A Chinese herbal acne-removing composition comprises the following components by mass fraction: 5-15% moisturizer, 5-20% phellodendron chinense extract, 5-20% coptis chinensis extract, 0.1-1% allantoin, 0.05-0.3% dipotassium glycyrrhizinate, 0.5-4% skin conditioner, 0.5-2% preservative, 0.2-0.8% thickener, 0.1-5% auxiliary material, the sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler.

[0006] The Chinese herbal acne-removing composition proposed by the present invention mainly uses Phellodendron chinense extract, Coptis chinensis extract, allantoin and dipotassium glycyrrhizinate as the main acne-removing composition, wherein the Coptis chinensis extract and the Phellodendron chinense extract contain a large amount of alkaloids, have the effects of clearing away heat and detoxifying, reducing swelling and dispersing nodules, and have anti-inflammatory and antibacterial effects. It has a strong inhibitory effect on Gram-positive bacteria, and can inhibit bacterial growth by affecting the loss of intracellular calcium ions, inhibiting DNA replication, RNA transcription and protein synthesis, thereby controlling bacterial reactions, accelerating skin renewal, reducing wound inflammatory reactions, promoting granulation tissue formation, and rapid proliferation of fibroblasts, thereby accelerating the process of tissue wound healing. Therefore, the Chinese herbal acne-removing composition has the effect of regulating the reproduction of pathogenic bacteria such as Propionibacterium acnes and Staphylococcus aureus to achieve the effect of removing acne, and has multiple functions such as moisturizing, soothing and removing acne.

[0007] In addition, the Chinese herbal acne-removing composition provided by the present invention may also have the following additional technical features: Preferably, the Chinese herbal acne-removing composition comprises the following components by mass fraction: 6% moisturizer, 10% phellodendron extract, 10% coptis extract, 0.3% allantoin, 0.2% dipotassium glycyrrhizinate, 0.95% skin conditioner, 0.6% preservative, 0.7% thickener, and 0.5% excipient. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler.

[0008] Preferably, the moisturizing agent is any one or more combinations of glycerol, 1,3-propanediol, butylene glycol, propylene glycol, and 1,2-hexanediol.

[0009] Preferably, the preservative is a combination of one or more of phenoxyethanol, p-hydroxyacetophenone, and ethylhexylglycerin.

[0010] Preferably, the skin conditioning agent is a combination of one or more of arginine, panthenol, papain, niacinamide, and sodium PCA.

[0011] Preferably, the auxiliary material is any one or more combinations of disodium EDTA, maltodextrin and triethanolamine.

[0012] Preferably, the thickener is any one or more combinations of carbomer, propylene glycol / C10-30 alkyl acrylate crosspolymer, acrylic acid / C10-30 alkyl acrylate crosspolymer, ammonium acryloyldimethyl taurate / beheneth-25 methacrylate crosspolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, and xanthan gum.

[0013] Preferably, the filler is water.

[0014] The present invention also provides a method for preparing a Chinese herbal medicine anti-acne composition, comprising the following steps: (1) Homogenize the filler, thickener, humectant, allantoin, and excipients and heat them to a first preset temperature until they are completely dissolved; (2) When the temperature cools down to below the second preset temperature, add a skin conditioning agent and stir evenly; (3) Add Phellodendron amurense extract, Coptis chinensis extract, preservatives and dipotassium glycyrrhizinate in sequence, stir evenly and filter out the material.

[0015] In addition, the preparation method of the Chinese herbal anti-acne composition provided by the present invention may also have the following additional technical features: Preferably, the first preset temperature is 65-75°C, and the second preset temperature is 50°C.

[0016] The beneficial effects of the present invention include at least: (1) The extracts of Coptis chinensis and Phellodendron amurense contain a large amount of alkaloids, which have the effects of clearing away heat and detoxifying, reducing swelling and dispersing nodules, and have anti-inflammatory and antibacterial effects. The antibacterial effects of Coptis chinensis and Phellodendron amurense are mostly manifested in the antibacterial activity of berberine. Berberine has a strong inhibitory effect on Gram-positive bacteria and can inhibit bacterial growth by affecting the loss of intracellular calcium ions, inhibiting DNA replication, RNA transcription and protein synthesis. Berberine can control the bacterial response by upregulating the expression of its mitochondrial synthesis gene TRAM; (2) Allantoin and dipotassium glycyrrhizinate can promote the growth of cell tissues, affect the rapid granulation process of the epidermis, accelerate skin renewal, reduce the inflammatory response of the wound surface, promote the formation of granulation tissue, and the rapid proliferation of fibroblasts, thereby accelerating the healing process of tissue wounds; (3) The Chinese herbal acne-removing composition provided in the present application has the effect of regulating the reproduction of pathogenic bacteria such as Propionibacterium acnes and Staphylococcus aureus on the skin to achieve the effect of removing acne, and has multiple functions such as moisturizing, soothing and removing acne.

[0017] Additional aspects and advantages of the present invention will be given in part in the following description and in part will be obvious from the following description, or will be learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0019] Figure 1 A face image that is a valid example of skin redness; Figure 2 This is a facial image showing a valid example of the volume of a single pimple.

[0020] The embodiments of the present invention will be further described below with reference to the accompanying drawings. DETAILED DESCRIPTION

[0021] In order to make the purpose, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below in conjunction with the examples. Several embodiments of the present invention are given in the examples. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. On the contrary, the purpose of providing these embodiments is to make the disclosure of the present invention more thorough and comprehensive.

[0022] Example 1 A Chinese herbal acne-removing composition comprises the following components by mass fraction: 6% moisturizer, 10% phellodendron chinense extract, 10% coptis chinensis extract, 0.3% allantoin, 0.2% dipotassium glycyrrhizinate, 0.95% skin conditioner, 0.6% preservative, 0.7% thickener, and 0.5% auxiliary material, the sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler.

[0023] The moisturizer is 3% glycerol and 3% 1,3-propylene glycol; the skin conditioner is 0.7% arginine, 0.2% panthenol and 0.05% papain; the preservative is 0.5% phenoxyethanol and 0.1% ethylhexylglycerin; the auxiliary material is 0.05% disodium EDTA and 0.45% maltodextrin; and the filler is water; It should be noted that the Phellodendron chinense extract can be obtained by the following method: weigh 100g of Phellodendron chinense, crush it, and extract it in a water bath at 80°C (80% ethanol aqueous solution) for 1.5 hours according to a feed ratio of 1:10; filter the residue in the extract, centrifuge the supernatant (7000r / min, 20min), and concentrate and filter the supernatant to obtain the final product, which is the Coptis chinensis extract; The coptis root extract can be obtained by the following method: weigh 100g of coptis root, crush it, and extract it in a water bath at 80°C (80% ethanol aqueous solution) for 1.5 hours according to a feed ratio of 1:10; filter the residue in the extract, centrifuge the supernatant (7000r / min, 20min), and concentrate and filter the supernatant to obtain the final product, which is the phellodendron chinense extract.

[0024] The main acne-removing composition is composed of coptis root extract, coptis root extract, allantoin and dipotassium glycyrrhizinate. Coptis root has the function of "traditional Chinese medicine antibiotic", and has the functions of clearing heat and dampness, purging fire and detoxifying. Coptis root is bitter, cold in nature, non-toxic, and has the functions of clearing heat and dampness, purging fire and removing steam, detoxifying and curing sores. It has antibacterial and anti-inflammatory effects. Coptis root extract and coptis root extract contain a large amount of alkaloids, which have the functions of clearing heat and detoxifying, reducing swelling and dispersing knots, and anti-inflammatory and antibacterial effects. The antibacterial effects of coptis root and coptis root are mostly manifested as the antibacterial activity of berberine. Berberine has a strong inhibitory effect on Gram-positive bacteria, and can inhibit bacterial growth by affecting the loss of intracellular calcium ions, inhibiting DNA replication, RNA transcription and protein synthesis. Berberine can control the response of bacteria by upregulating the expression of its mitochondrial synthesis gene TRAM. Allantoin and dipotassium glycyrrhizinate can promote the growth of cell tissues, affect the rapid granulation process of the epidermis, accelerate skin renewal, reduce wound inflammation, promote granulation tissue formation, and rapid proliferation of fibroblasts, thereby accelerating the healing process of tissue wounds. The composition has the effect of regulating the reproduction of Propionibacterium acnes in the skin to achieve acne removal, and has multiple functions such as moisturizing, soothing and acne removal.

[0025] The preparation method of the above-mentioned Chinese herbal medicine acne-removing composition comprises the following steps: (1) Homogenize the filler, thickener, humectant, allantoin and excipients and heat to 65-75°C until they are completely dissolved; (2) When the temperature cools down to below 50°C, add the skin conditioner and stir evenly; (3) Add Phellodendron amurense extract, Coptis chinensis extract, preservatives and dipotassium glycyrrhizinate in sequence, stir evenly and filter out the material.

[0026] Example 2 The present embodiment provides a Chinese herbal acne-removing composition, which includes the following components by mass fraction: 6% moisturizer, 10% coptis root extract, 0.3% allantoin, 0.2% dipotassium glycyrrhizinate, 0.95% skin conditioner, 0.6% preservative, 0.7% thickener, and 0.5% auxiliary material. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between this embodiment and embodiment 1 is that no phellodendron extract is added in this embodiment.

[0027] Example 3 The present embodiment provides a Chinese herbal acne-removing composition, which includes the following components by mass fraction: 6% moisturizer, 10% phellodendron extract, 0.3% allantoin, 0.2% dipotassium glycyrrhizinate, 0.95% skin conditioner, 0.6% preservative, 0.7% thickener, and 0.5% auxiliary material. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between this embodiment and embodiment 1 is that no coptis extract is added in this embodiment.

[0028] Example 4 The present embodiment provides a Chinese herbal acne-removing composition, which includes the following components by mass fraction: 6% moisturizer, 10% phellodendron extract, 10% coptis extract, 0.2% dipotassium glycyrrhizinate, 0.95% skin conditioner, 0.6% preservative, 0.7% thickener, and 0.5% auxiliary material. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between this embodiment and embodiment 1 is that allantoin is not added in this embodiment.

[0029] Example 5 The present embodiment provides a Chinese herbal acne-removing composition, which includes the following components by mass fraction: 6% moisturizer, 10% phellodendron extract, 10% coptis extract, 0.3% allantoin, 0.95% skin conditioner, 0.6% preservative, 0.7% thickener, and 0.5% auxiliary material. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between this embodiment and embodiment 1 is that dipotassium glycyrrhizinate is not added in this embodiment.

[0030] Example 6 The present embodiment provides a Chinese herbal acne-removing composition, comprising the following components by mass fraction: 6% moisturizer, 5% phellodendron extract, 5% coptis chinensis extract, 0.3% allantoin, 0.2% dipotassium glycyrrhizinate, 0.95% skin conditioner, 0.6% preservative, 0.7% thickener, and 0.5% auxiliary material. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and embodiment 1 is that the mass fraction of the phellodendron chinensis extract in the present embodiment is 5%, and the mass fraction of the coptis chinensis extract is 5%.

[0031] Example 7 The present embodiment provides a Chinese herbal acne-removing composition, comprising the following components by mass fraction: 6% moisturizer, 20% phellodendron extract, 20% coptis chinensis extract, 0.3% allantoin, 0.2% dipotassium glycyrrhizinate, 0.95% skin conditioner, 0.6% preservative, 0.7% thickener, and 0.5% auxiliary material. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and embodiment 1 is that the mass fraction of the phellodendron chinensis extract in the present embodiment is 20%, and the mass fraction of the coptis chinensis extract is 20%.

[0032] Example 8 The present embodiment provides a Chinese herbal acne-removing composition, which includes the following components by mass fraction: 6% moisturizer, 10% phellodendron extract, 10% coptis extract, 0.1% allantoin, 0.05% dipotassium glycyrrhizinate, 0.95% skin conditioner, 0.6% preservative, 0.7% thickener, and 0.5% auxiliary material. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between the present embodiment and embodiment 1 is that the mass fraction of allantoin in the present embodiment is 0.1%, and the mass fraction of dipotassium glycyrrhizinate is 0.05%.

[0033] Example 9 The present embodiment provides a Chinese herbal acne-removing composition, which includes the following components by mass fraction: 6% moisturizer, 10% phellodendron extract, 10% coptis extract, 1% allantoin, 0.3% dipotassium glycyrrhizinate, 0.95% skin conditioner, 0.6% preservative, 0.7% thickener, and 0.5% auxiliary material. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler. The difference between this embodiment and embodiment 1 is that the mass fraction of allantoin in this embodiment is 1%, and the mass fraction of dipotassium glycyrrhizinate is 0.3%.

[0034] Comparative Example 1 This control example is basically the same as Example 1, except that: in this control example, no Phellodendron chinense extract, Coptis chinensis extract, allantoin, or dipotassium glycyrrhizinate is added.

[0035] Comparative Example 2 This control example is basically the same as Example 1, except that: Phellodendron amurense extract and Coptis chinensis extract are not added in this control example.

[0036] Comparative Example 3 This control example is basically the same as Example 1, except that: allantoin and dipotassium glycyrrhizinate are not added in this control example.

[0037] The Chinese herbal acne-removing composition obtained in the above embodiments and control examples was prepared into an acne-removing stock solution, and the corresponding culture medium was selected to culture Propionibacterium acnes ATCC11827 and Staphylococcus aureus ATCC6538. The selected test instruments were an anaerobic incubator, a biological safety cabinet, and a low-temperature constant temperature bath. It should be noted that each of the above control examples and embodiments has three groups of experimental samples corresponding to each other, and the three groups of test samples have corresponding control groups. The corresponding antibacterial effect is determined by the antibacterial circle diameter of the corresponding bacterial species, and then the average antibacterial circle diameter of the three groups of experimental samples is obtained as the final antibacterial result. The antibacterial circle diameter results of the above embodiments and control examples are shown in Table 1 below: Table 1

[0038] At the same time, the Chinese herbal acne-removing composition obtained in the above embodiments and control examples was prepared into an acne-removing stock solution, and a hyaluronidase inhibition test was performed on it. The solutions required for the test were acetic acid buffer, hyaluronidase solution, sodium hyaluronate solution, and hexadecyltrimethylammonium bromide (CTAB) solution. The instruments required for the test were: an analytical balance (model HX50002), an electric constant temperature incubator (model HSX-250), and an ELISA reader (model SpectralMAX i3). First, for each acne-removing stock solution, it was diluted into three sample solutions of different concentrations according to a certain ratio, and the three concentrations increased in sequence. The three sample solutions were recorded as the first solution, the second solution, and the third solution in order from high to low concentrations. The concentrations of the first solution, the second solution, and the third solution were 0.063 g / ml, 0.125 g / ml, and 0.25 g / ml, respectively; For each sample solution, it was divided into two groups, namely A and B. 0.1 ml of hyaluronidase solution was added to solution A, incubated at 37°C for 10 min, then 0.1 ml of 0.04% sodium hyaluronate solution was added, enzymatically hydrolyzed at 37°C for 45 min, then 0.2 ml of CTAB solution was added, precipitated at 37°C for 5 min, 200 uL of the reaction solution was aspirated into a 96-well plate, and the absorbance at 400 nm was measured to obtain result A; 0.1 ml of acetic acid buffer was added to solution B, incubated at 37°C for 10 min, then 0.1 ml of 0.04% sodium hyaluronate solution was added, enzymatically hydrolyzed at 37°C for 45 min, then 0.2 ml of CTAB solution was added, precipitated at 37°C for 5 min, 200 uL of the reaction solution was aspirated into a 96-well plate, and the absorbance at 400 nm was measured to obtain result B; Take 0.1 ml of grade 3 water, add 0.1 ml of hyaluronidase solution to the grade 3 water, incubate at 37°C for 10 min, then add 0.1 ml of 0.04% sodium hyaluronate solution, enzymolysis at 37°C for 45 min, then add 0.2 ml of CTAB solution, precipitate at 37°C for 5 min, aspirate 200 uL of the solution after the reaction in a 96-well plate, and measure the absorbance at 400 nm to obtain result C; weigh 0.1 ml of grade 3 water, add 0.1 ml of acetic acid buffer to the grade 3 water, incubate at 37°C for 10 min, then add 0.1 ml of 0.04% sodium hyaluronate solution, enzymolysis at 37°C for 45 min, then add 0.2 ml of CTAB solution, precipitate at 37°C for 5 min, aspirate 200 uL of the solution after the reaction in a 96-well plate, and measure the absorbance at 400 nm to obtain result D; The specific calculation result of the hyaluronidase inhibition rate is {(D result-C result)-(B result-A result)} / (D result-C result)×100%. The above operation is performed on the first solution, the second solution and the third solution in each embodiment and the control example, and the hyaluronidase inhibition rate thereof is calculated. The hyaluronidase inhibition rate of the third solution is selected as the final hyaluronidase inhibition rate test result. Whether the sample has a soothing effect is determined based on whether the hyaluronidase inhibition rates of the first solution, the second solution and the third solution are in an increasing relationship. For details, please refer to Table 2: Table 2

[0039] Please refer to Table 1. For Comparative Examples 2 and 3, when one of the Phellodendron chinense extract and the Coptis chinensis extract is missing, the diameters of the inhibition zones for the two experimental strains are significantly reduced compared with Example 1. For Comparative Examples 4 and 5, when one of allantoin and dipotassium glycyrrhizinate is missing, the antibacterial rate is also reduced compared with Example 1, but the extent of the reduction is not as high as that of Examples 2 and 3. For Comparative Examples 6 and 7, when the content of the Phellodendron chinense extract and the Coptis chinensis extract in the herbal acne-removing composition is too high or too low, the antibacterial rate will also be affected. If it is too low, the best effect cannot be achieved, and if it is too high, the antibacterial effect may be partially affected. However, for Comparative Examples 2 and 5, the antibacterial rate of the two experimental strains is significantly reduced compared with Example 1. 3, 4, and 5, and the antibacterial effect is also relatively good. For the control group 1, no Phellodendron chinense extract, Coptis chinensis extract, allantoin, and dipotassium glycyrrhizinate were added, so the minimum diameter of the antibacterial zone for the two strains was 0 mm. It should be noted that in this application, the diameter of the antibacterial zone is less than 5 mm, which is recorded as 0. By comparing Example 1 with Control Examples 2 and 3, it can be seen that adding allantoin and dipotassium glycyrrhizinate to the Chinese herbal acne-removing composition, and coptis chinensis extract and Coptis chinensis extract can further improve the acne-removing performance of the sample, and allantoin, dipotassium glycyrrhizinate, Phellodendron chinense extract and Coptis chinensis extract can play a synergistic role and improve the antibacterial effect; Meanwhile, referring to Table 1, Examples 1-9, and Comparative Examples 1, 2, and 3, it can be seen that Phellodendron chinense extract, Coptis chinensis extract, allantoin, and dipotassium glycyrrhizinate are used as the main anti-acne ingredients. Phellodendron chinense extract and Coptis chinensis extract are direct antibacterial anti-acne components, which have the functions of clearing away heat and dampness, purging fire and detoxifying, clearing heat and dampness, purging fire and removing steam, and detoxifying and curing sores. Among them, Coptis chinensis extract and Phellodendron chinense extract contain a large amount of alkaloids, which have the functions of clearing heat and detoxifying, reducing swelling and dispersing nodules, and anti-inflammatory and antibacterial effects. The antibacterial effects of Coptis chinensis and Phellodendron chinense are mostly manifested in the antibacterial activity of berberine, which has the functions of clearing heat and detoxifying, reducing swelling and dispersing nodules, and anti-inflammatory and antibacterial effects. The antibacterial effects of Coptis chinensis and Phellodendron chinense are mostly manifested in the antibacterial activity of berberine. It has a strong inhibitory effect on Gram-positive bacteria. It can inhibit bacterial growth by affecting the loss of intracellular calcium ions, inhibiting DNA replication, RNA transcription and protein synthesis. At the same time, it can control the bacterial response by upregulating the expression of its mitochondrial synthesis gene TRAM. Allantoin and dipotassium glycyrrhizinate are auxiliary antibacterial and acne-removing ingredients. They can promote the growth of cell tissues, affect the rapid granulation process of the epidermis, accelerate skin renewal, reduce wound inflammatory response, promote granulation tissue formation, and rapid proliferation of fibroblasts, thereby accelerating the healing process of tissue wounds. Please refer to Table 2. When the hyaluronidase inhibition rates of the first solution, the second solution and the third solution satisfy an increasing relationship, it can be considered that the sample has a soothing effect. From Example 1 and Control Examples 1, 2 and 3, it can be seen that allantoin and dipotassium glycyrrhizinate are the main soothing costs. The sample of Example 1 has the best soothing effect. When the sample does not contain allantoin and dipotassium glycyrrhizinate, the soothing effect of the sample is not good and approaches zero. From Examples 2, 3, 6 and 7, it can be seen that the Phellodendron chinense extract and the Coptis chinensis extract have a relatively low effect on the soothing effect. From Examples 4 and 5, it can be seen that the lack of any one of allantoin and dipotassium glycyrrhizinate will have a greater impact on the soothing effect. At the same time, from It can be seen from Examples 8 and 9 that when the content of allantoin and dipotassium glycyrrhizinate in the herbal acne-removing composition is too high or too low, it will also affect its soothing performance. At the same time, by comparing Example 1 with Control Example 2, it can be learned that adding allantoin and dipotassium glycyrrhizinate to the herbal acne-removing composition, combined with Phellodendron chinense extract and Coptis chinensis extract, can further enhance the soothing performance of the sample. Allantoin and dipotassium glycyrrhizinate can promote the growth of cell tissue, affect the rapid granulation process of the epidermis, accelerate skin renewal, reduce wound inflammatory response, promote granulation tissue formation, and rapid proliferation of fibroblasts, thereby accelerating the process of tissue wound healing, and has multiple functions such as moisturizing, soothing and acne removal.

[0040] In order to further verify the effectiveness of the Chinese herbal acne-removing composition provided in the present application, a cosmetic human experiment was conducted. The experimental method was derived from T / CAB 015-2022 Cosmetic Anti-wrinkle, Firming, Moisturizing, Oil Control, Repair, Nourishing, Soothing Seven Efficacy Test Methods, T / GDCDC 023-2022 Cosmetic Acne-Removing Efficacy Test Method, Cosmetic Oil Control Efficacy Human Evaluation Method, Cosmetic Soothing Efficacy Test Method. At the same time, the efficacy judgment indicators of the Chinese herbal acne-removing composition are: oil control efficacy is the skin oil content, acne efficacy is the clinical evaluation of dermatologists (acne), Antera 3D single acne volume, and soothing efficacy is Antera 3D skin redness a* value; The experimental equipment is the skin oil tester Sebumeter SM815 and the skin imaging measuring instrument Antera 3D. The experimental population is 32 healthy people aged 25-60 years old, with at least one active acne, oily skin, or acne on the face. The temperature and humidity must be kept appropriate during the experiment; The Chinese herbal anti-acne composition of the present application was prepared into an anti-acne gel, which was used continuously for 28 days on the above 32 test subjects. The method of use was to apply it evenly on the acne and blackheads, and the frequency of use was twice a day; At the same time, before the above test subjects conducted the test, they cleaned their faces and wiped their skin with dry tissues, sat in a laboratory with a temperature of 21°C ± 1°C and a humidity of 50%RH ± 10%RH for 30 minutes, and used relevant experimental instruments to collect the test subjects' facial data, which was used as the blank group D0; similarly, after the test subjects used the acne gel for 28 days, they cleaned their faces and wiped their skin with dry tissues, sat in a laboratory with a temperature of 21°C ± 1°C and a humidity of 50%RH ± 10%RH for 30 minutes, and used relevant experimental instruments to collect the test subjects' facial data, which was used as the experimental group D28, and after the test subjects used the acne gel, they were asked about adverse reactions, and it was reported that none of the 32 test subjects had adverse reactions, and the following test results are the average values ​​of the 32 test subjects; The skin oil content of the blank group and the experimental group is shown in Table 3: Table 3

[0041] The volume of a single acne in the blank group and the experimental group is shown in Table 4: Table 4

[0042] The skin redness a* values ​​of the blank group and the experimental group are shown in Table 5: Table 5

[0043] The number of acne in the blank group and the experimental group is shown in Table 6: Table 6

[0044] Afterwards, 28 days after the experiment, the subjects were asked to self-evaluate. The results are shown in Table 7: Table 7

[0045] Note: Evaluation index: 1 is "strongly disagree", 2 is "disagree", 3 is "neutral", 4 is "agree", 5 is "strongly agree", and the sample size is 32.

[0046] According to the above test results, after using the acne gel, the improvement rate of skin oil content, the improvement rate of acne volume, the improvement rate of skin redness a* value, and the improvement rate of acne number were 8.95%. Therefore, the experimental group values ​​of skin oil content, single acne volume, skin redness a* value, and acne number were significantly improved compared with the blank group. It is believed that the Chinese herbal acne composition of the present application has acne removal, oil control, and soothing effects, and 90.63% of the subjects effectively improved redness after using the product, 93.75% of the subjects had soothing skin after using the product, 93.75% of the subjects effectively improved acne after using the product, 93.75% of the subjects had obvious acne reduction after using the product, and 87.50% of the subjects had reduced oil secretion after use. It is believed that the Chinese herbal acne composition of the present application has acne removal, oil control, and soothing effects.

[0047] Here are some effective examples to prove the effect of this application: Figure 1 As shown, Figure 1 A face image showing an effective example of skin redness. Figure 1 RD0009 and RD0032 were the 9th and 32nd experimenters respectively. Figure 1 It can be seen that after 28 days, the redness of the subjects' skin was significantly improved. Figure 2 As shown, Figure 2 This is a facial image showing a valid example of the volume of a single pimple. Figure 2 RD00010 and RD0024 are the 10th and 24th experimenters respectively. Figure 2 It can be seen that after 28 days, the size of each pimple of the test subject was significantly reduced.

[0048] It is worth noting that, in another embodiment of the present invention, a Chinese herbal anti-acne gel is provided. The Chinese herbal anti-acne gel can be prepared from the Chinese herbal anti-acne composition in the above embodiment, and comprises the following components by mass fraction: Moisturizer (1,3-propylene glycol 3%, glycerin 3%), Phellodendron chinense extract 10%, Coptis chinensis extract 10%, allantoin 0.3%, dipotassium glycyrrhizinate 0.2%, skin conditioner (arginine 0.7%, panthenol 0.2%, papain 0.05%), preservative (phenoxyethanol 0.5%, ethylhexylglycerin 0.1%), thickener 0.7%, excipients (disodium EDTA 0.05%, maltodextrin 0.45%). The sum of the mass fractions of the above components shall not exceed 100%, and the remainder is filler.

[0049] Its preparation method is: (1) Homogenize water, thickener, glycerin, 1,3-propylene glycol, allantoin, and disodium EDTA, and heat to 65-75°C until completely dissolved; (2) When the temperature drops below 50°C, add panthenol, ethylhexylglycerin, maltodextrin, and papain and mix well; (3) Add Phellodendron amurense extract, Coptis chinensis extract, phenoxyethanol, dipotassium glycyrrhizinate and arginine in sequence, stir evenly and filter out the material.

[0050] In another embodiment of the present invention, a Chinese herbal acne-removing essence is provided. The Chinese herbal acne-removing essence can be prepared from the Chinese herbal acne-removing composition in the above embodiment, and comprises the following components by mass fraction: Moisturizer (butylene glycol 5%, propylene glycol 4%, 1, 2-hexanediol 0.5%), Phellodendron chinense extract 6%, Coptis chinensis extract 6%, allantoin 0.3%, dipotassium glycyrrhizate 0.25%, skin conditioner (niacinamide 1%, sodium PCA 0.5%), preservative (p-hydroxyacetophenone 0.5%), thickener 0.2%, excipient (disodium EDTA 0.05%). The sum of the mass fractions of the above components shall not exceed 100%, and the remainder is filler.

[0051] Its preparation method is: (1) Homogenize water, thickener, propylene glycol, allantoin, disodium EDTA, and p-hydroxyacetophenone, and heat to 65-75°C until completely dissolved; (2) When the temperature drops below 50°C, add butanediol, niacinamide, sodium PCA, and 1,2-hexanediol and stir evenly; (3) Add Phellodendron amurense extract, Coptis chinensis extract and dipotassium glycyrrhizinate in sequence, stir evenly and filter out the material.

[0052] In another embodiment of the present invention, a Chinese herbal anti-acne gel is provided. The Chinese herbal anti-acne gel can be prepared from the Chinese herbal anti-acne composition in the above embodiment, and comprises the following components by mass fraction: Moisturizer (butylene glycol 5%, propylene glycol 4%, 1, 2-hexanediol 0.5%), Phellodendron chinense extract 10%, Coptis chinensis extract 6%, allantoin 0.2%, dipotassium glycyrrhizinate 0.25%, skin conditioner (niacinamide 1%), preservative (p-hydroxyacetophenone 0.5%), thickener 0.8%, excipients (disodium EDTA 0.05%, triethanolamine 0.7%). The sum of the mass fractions of the above components shall not exceed 100%, and the remainder is filler.

[0053] Its preparation method is: (1) Homogenize water, thickener, propylene glycol, allantoin, disodium EDTA, and p-hydroxyacetophenone, and heat to 65-75°C until completely dissolved; (2) When the temperature drops below 50°C, add butanediol, niacinamide, and 1,2-hexanediol and stir evenly; (3) Add Phellodendron amurense extract, Coptis chinensis extract, dipotassium glycyrrhizinate and triethanolamine in sequence, stir evenly and filter out the material.

[0054] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "example", "specific example", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0055] The above-mentioned embodiments only express several implementation methods of the present invention, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the present invention. It should be pointed out that, for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the present invention, which all belong to the protection scope of the present invention. Therefore, the protection scope of the patent of the present invention shall be subject to the attached claims.

Claims

1. A Chinese herbal medicine acne-removing composition, characterized in that: The composition includes the following components by mass fraction: humectant 5-15%, phellodendron amurense extract 5-20%, coptis chinensis extract 5-20%, allantoin 0.1-1%, dipotassium glycyrrhizinate 0.05-0.3%, skin conditioner 0.5-4%, preservative 0.5-2%, thickener 0.2-0.8%, auxiliary material 0.1-5%. The sum of the mass fractions of the above components shall not exceed 100%, and the remainder is filler.

2. The Chinese herbal acne-removing composition according to claim 1, characterized in that: The Chinese herbal acne-removing composition comprises the following components by mass fraction: 6% moisturizer, 10% phellodendron extract, 10% coptis root extract, 0.3% allantoin, 0.2% dipotassium glycyrrhizinate, 0.95% skin conditioner, 0.6% preservative, 0.7% thickener, and 0.5% auxiliary material. The sum of the mass fractions of the above components does not exceed 100%, and the remainder is filler.

3. The Chinese herbal anti-acne composition according to claim 1, characterized in that: The moisturizing agent is any one or more combinations of glycerol, 1,3-propanediol, butylene glycol, propylene glycol, and 1,2-hexanediol.

4. The Chinese herbal acne-removing composition according to claim 1, characterized in that: The preservative is a combination of one or more of phenoxyethanol, p-hydroxyacetophenone, and ethylhexylglycerin.

5. The Chinese herbal anti-acne composition according to claim 1, characterized in that: The skin conditioning agent is a combination of one or more of arginine, panthenol, papain, niacinamide and sodium PCA.

6. The Chinese herbal anti-acne composition according to claim 1, characterized in that: The auxiliary material is any one or more combinations of disodium EDTA, maltodextrin and triethanolamine.

7. The Chinese herbal anti-acne composition according to claim 1, characterized in that: The thickener is any one or more of carbomer, propylene glycol / C10-30 alkyl acrylate cross-linked polymer, acrylic acid / C10-30 alkyl acrylate cross-linked polymer, ammonium acryloyldimethyl taurate / beheneth-25 methacrylate cross-linked polymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, and xanthan gum.

8. The Chinese herbal anti-acne composition according to claim 1, characterized in that: The filler is water.

9. The method for preparing the Chinese herbal anti-acne composition according to any one of claims 1 to 8, characterized in that: The following steps are involved: (1) Homogenize the filler, thickener, humectant, allantoin, and excipients and heat them to a first preset temperature until they are completely dissolved; (2) When the temperature is cooled to below the second preset temperature, add a skin conditioning agent and stir evenly; (3) Add Phellodendron amurense extract, Coptis chinensis extract, preservatives and dipotassium glycyrrhizinate in sequence, stir evenly and filter out the material.

10. The method for preparing the Chinese herbal anti-acne composition according to claim 9, characterized in that: The first preset temperature is 65-75°C, and the second preset temperature is 50°C.

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