Composition with anti-hair loss effect as well as preparation method and application thereof

Abstract

The invention discloses a composition with a multi-dimensional anti-hair loss effect as well as a preparation method and application of the composition. The composition with the hair loss preventing effect is prepared from the following components in percentage by mass: 2 to 20 percent of a leaf extract of THUJA ORINTALIS, 0.1 to 2 percent of a root extract of ZINGIBER OFFICINALE, 0.1 to 5 percent of a leaf extract of NELUMBO NUCIFERA, 1 to 10 percent of a root extract of REHMANNIA GLUTINOSA, 0.1 to 0.5 percent of caffeine, 0.5 to 10 percent of schizophyllan and the balance of conventional daily chemical product additives and water. The multi-dimensional anti-hair loss shampoo can prevent hair loss and hair loss through controlling oil, resisting oxidation, promoting hair growth, promoting blood circulation, nourishing and strengthening hair and the like, and solves the problem of scalp health of consumers.

Description

Technical Field

[0001] The present invention belongs to the technical field of daily chemical products, and specifically relates to a composition with multi-dimensional anti-hair loss effects, and a preparation method and application thereof. Background Art

[0002] In the fiercely competitive modern society, many people are facing various work and family pressures, mental stress, lack of sleep, irregular lifestyle, endocrine disorders and other problems, which are prone to hair loss, and the phenomenon tends to be younger. Statistics show that there are about 200 million people with hair loss in China, of which about 130 million are men, and the male hair loss rate in my country is nearly 20%. Hair loss has become a psychological problem for people.

[0003] Hair is composed of hair shaft and hair root, which are keratinized cell proteins. Hair follicles are bag-like epithelium formed by continuous epidermal cells. Hair follicles are connected to capillaries in the dermis through the hair papilla at the bottom of the hair follicles, which transport nutrients to the hair and keep the hair growing.

[0004] Hair loss can be divided into physiological hair loss and pathological hair loss. Physiological hair loss refers to hair loss in the regression and resting phases, while pathological hair loss refers to abnormal or excessive hair loss. Pathological hair loss is usually divided into androgenic alopecia, nutritional alopecia, physical alopecia, endocrine alopecia, and infectious alopecia. The reason is that the scalp is unhealthy, oil oxidation damages the hair follicles, the hair follicles atrophy and degenerate, the hair follicle cells age and die, the hair cannot absorb nutrients, the hair stops growing, and hair loss and hair breakage occur.

[0005] At present, the anti-hair loss products on the market mainly include Western medicine care products, represented by sildenafil and minoxidil, and Chinese herbal care products, which often contain Platycladus orientalis leaf extract. The former has serious side effects, such as hair loss and hypotension; the latter is often not ideal and far from meeting consumers' expectations.

[0006] Consumers are looking forward to an effective multi-dimensional anti-hair loss composition solution that can fundamentally maintain scalp health, control oil and anti-oxidation, promote hair growth, and nourish and strengthen hair. Summary of the invention

[0007] 1. Technical issues to be resolved

[0008] The purpose of the present invention is to provide a composition with multi-dimensional anti-hair loss efficacy and a preparation method and application thereof.

[0009] (II) Technical solution

[0010] To achieve the above object, the present invention provides the following technical solution: an anti-hair loss efficacy composition, comprising efficacy components, conventional daily chemical additive components and water, characterized in that: the efficacy components, conventional daily chemical additive components and water comprise the following components in the following mass percentage ratios:

[0011] Thuja orientalis leaf extract 2-20%, ginger root extract 0.1-2%, lotus leaf extract 0.1-5%, rehmannia root extract 1-10%, caffeine 0.1-0.5%, schizophyllanthus acidophilus 0.5-10%; the conventional daily chemical additive components can be selected from surfactant 1-20%, moisturizer 2-8%, thickener 0.2-1%, preservative 0.3-0.7%, and the balance is water.

[0012] The functional components in the anti-hair loss efficacy composition of the present invention are:

[0013] Platycladus orientalis leaf extract: Platycladus orientalis leaf is the dried branches and leaves of the Cupressaceae plant Platycladus orientalis. It is a traditional Chinese medicine with a wide range of origins and is one of the important medicinal materials commonly used in clinical hair growth and darkening in traditional Chinese medicine. According to traditional Chinese medicine records, Platycladus orientalis leaf is cold and enters the blood to dispel wind, and has the effect of growing and darkening hair. It is suitable for hair loss caused by blood heat and premature graying of hair.

[0014] The main ingredients of Platycladus orientalis leaves for hair loss prevention include volatile oil (content 0.6-1%, mainly containing thujene, thujone, fenchone, pinene, caryophyllene, etc.), flavonoids (such as citrus aurantium, quercetin, myricetin, cypress biflavonoids, tachyphyllum biflavonoids, etc.), tannins, resins, vitamin C, etc. The volatile oil components in Platycladus orientalis leaves have antibacterial and vasodilatory effects, which can improve blood circulation in the scalp and promote hair growth. The total flavonoid components in Platycladus orientalis leaves can activate hair matrix cells, enhance the metabolic function of hair follicles, revive hair follicles with declining hair growth ability, and supplement the nutrients needed by hair, thereby playing a role in nourishing and promoting hair growth. In addition, the volatile oil and flavonoid components in Platycladus orientalis leaves have an inhibitory effect on fungi such as Malassezia, can reduce scalp inflammation, and promote hair growth.

[0015] The Platycladus orientalis leaf extract of the present invention adopts an enzymatic hydrolysis method, an alcohol extraction method, an ultrasonic extraction method and a three-directional enrichment process to specifically enrich the potential components of the Platycladus orientalis leaves that play an anti-hair loss effect, increase the content of components such as quercetin, thujacetin and citrus aurantium, and enhance the anti-hair loss effect.

[0016] Ginger root extract: Ginger belongs to the genus Zingiberaceae, and is the fresh rhizome of ginger. Ginger has a pungent, warm and dispersing effect, and can be used to treat and relieve the symptoms of hair loss.

[0017] Ginger contains gingerol, zingiberene oil and other ingredients, which can promote scalp blood circulation, improve local metabolism, activate hair follicle tissue, provide more abundant nutrition to hair or hair follicles, effectively reduce hair loss and gray hair, and stimulate new hair growth. At the same time, ginger can also clean the scalp, remove excess oil on the scalp, and promote hair growth. In addition, ginger also has antibacterial and anti-inflammatory effects, which can protect scalp health, reduce scalp problems, and thus help hair growth.

[0018] Lotus leaf extract: The main ingredients include lotus leaf alkaloids, lotus leaf flavonoids, citric acid, oxalic acid, etc. Nuciferol is the main chemical component of lotus leaf extract, which can effectively decompose excess fat and has the function of regulating oil balance. Nuciferol can inhibit the proliferation of 3T3-L1 pre-adipocytes and reduce lipid synthesis in pre-adipocytes. In fully differentiated human primary ADSC (adipose stem cell) cells, the intracellular lipid content was significantly reduced after intervention with nuciferol. Nuciferol can significantly promote the phosphorylation of AMPK (an enzyme that regulates energy metabolism in human cells) in human adipocytes, promote fat decomposition, and reduce fat accumulation.

[0019] Rehmannia root extract: Rehmannia root is the fresh or dried root of Rehmannia root, a plant of the Scrophulariaceae family. Rehmannia root is one of the "Four Huai Medicines" and has been recorded in Mengzhou City, Henan Province for more than 1,000 years. It is cultivated in various parts of China and abroad. Rehmannia root can be divided into fresh Rehmannia root and dried Rehmannia root. The Compendium of Materia Medica records that fresh Rehmannia root has the effects of clearing heat, promoting fluid production, cooling blood, and stopping bleeding, while dried Rehmannia root has the effects of clearing heat, cooling blood, nourishing yin, and promoting fluid production.

[0020] Rehmannia root contains rehmannia glycosides A, B, C, D, dihydrocatalpol glycosides, aucubin, catalpol glycosides, rehmannia root, mannitol, various sugars and amino acids, vitamin A and other ingredients. The chemical composition of Rehmannia root is mainly glycosides, among which iridoid glycosides are the main ones, among which catalpol glycosides have the highest content, and the content of catalpol glycosides in fresh roots can reach 0.11%. Rehmannia root extract can promote the production of cholesterol, change the composition of sebum, inhibit oil secretion, and help maintain the freshness and balance of the skin. It can also promote the growth of fibrin and enhance the metabolism of the skin. At the same time, Rehmannia root can also promote the activity of cathepsin D, help prevent and treat skin inflammation and promote hair growth, and is used in hair growth and black hair products.

[0021] Caffeine: It is a xanthine alkaloid compound that exists naturally in the seeds, fruits and leaves of many plants, such as coffee, cocoa beans, tea, etc. At the same time, caffeine can also be artificially synthesized and added to beverages or foods as a food additive. Caffeine is a central nervous system (CNS) stimulant with multiple functions, such as increasing body energy levels, enhancing brain sensitivity, and increasing nerve excitability. At the same time, caffeine has a certain anti-hair loss effect, especially for androgenic alopecia.

[0022] Studies have shown that caffeine can inhibit the activity of TGF-β2 (transforming growth factor-β2), activate IGF-1 (insulin-like growth factor 1), and inhibit 5α reductase, thereby offsetting the inhibitory effect of dihydrotestosterone (DHT) on hair follicle growth, and has shown a significant effect in promoting hair follicle growth in in vitro experiments. In addition, caffeine can also activate the capillary microcirculation of the head skin, continuously supply nutrients to the hair through the blood, and promote rapid hair growth.

[0023] Schizophyllin: Schizophyllin, also known as white ginseng fungus, grows in the tropical rain forest of Yunnan and is a rare fungus that can be used as both medicine and food. Schizophyllin is extracted from white ginseng fungus and can activate a series of biological cascade reactions by specifically binding to the pattern recognition receptors of skin immune cells, soothing and repairing damaged skin, enhancing skin immune function, and strengthening the skin barrier.

[0024] Schizophyllan has different molecular weights. The present invention preferentially selects schizophyllan with a large molecular weight of 6 million to 10 million Daltons (content of 60-80%) and selects schizophyllan with a small molecular weight of 2000 to 5000 Daltons (content of 20-40%) for efficacy matching. The large molecular weight schizophyllan has good film-forming properties, can reduce the evaporation of water on the skin surface, and protect the skin tissue from secondary damage. The small molecular weight schizophyllan can penetrate the stratum corneum of the skin, enter the upper layer of the dermis and slowly release its efficacy, which has a deep moisturizing effect on deep cells, and can also inhibit the release of histamine, and has a soothing and repairing effect.

[0025] The conventional daily chemical additives in the anti-hair loss composition include one or a mixture of the following surfactants, moisturizers, thickeners, and preservatives:

[0026] Optional, surfactants: sodium laureth sulfate, cocamidopropyl betaine, cetearyl glucoside, ceteareth-20, glyceryl stearate, PEG-100 stearate, cetyl PEG / PPG-10 / 1 dimethicone;

[0027] Optional, humectants: glycerin, propylene glycol, butylene glycol, hexylene glycol, squalane, olive oil, erythritol, hydroxyethyl urea, panthenol;

[0028] Optional, thickener: sodium carbomer, acrylates / C10-30 alkyl acrylate crosspolymer, acrylates copolymer, xanthan gum, hydroxyethyl cellulose, hydroxypropyl methylcellulose, PEG-150 pentaerythritol tetrastearate, PEG-120 methyl glucose dioleate;

[0029] Optional, preservatives: hydroxyacetophenone, methylparaben, propylparaben, phenoxyethanol, sodium benzoate, benzyl alcohol, chlorphenesin, DMDM ​​hydantoin.

[0030] Furthermore, the anti-hair loss efficacy composition is characterized in that the efficacy components include: 20% Thuja orientalis leaf extract, 2% ginger root extract, 5% nelumbo nucifera leaf extract, 10% rehmannia glutinosa root extract, 0.5% caffeine, and 10% schizophyllan; the conventional daily chemical additive components can be selected from 20% surfactant, 8% humectant, 1% thickener, 0.7% preservative, and the balance is water.

[0031] Furthermore, the improvement of the present invention is that the anti-hair loss efficacy composition is characterized in that the efficacy components include: 2% THUJA ORIENTALIS leaf extract, 0.1% Zingiber OFFICINALE root extract, 0.1% NELUMBO NUCIFERA leaf extract, 1% REHMANNIA GLUTINOSA root extract, 0.1% caffeine, and 0.5% schizophyllan; the conventional daily chemical additive components can be selected from 1% surfactant, 2% humectant, 0.2% thickener, 0.3% preservative, and the balance is water.

[0032] Furthermore, the anti-hair loss efficacy composition is characterized in that the efficacy components include: 10% Thuja orientalis leaf extract, 1% ginger root extract, 2% nelumbo nucifera leaf extract, 5% rehmannia glutinosa root extract, 0.3% caffeine, and 5% schizophyllan; the conventional daily chemical additive components can be selected from 4% surfactant, 6% humectant, 0.5% thickener, 0.5% preservative, and the balance is water.

[0033] The anti-hair loss composition can be obtained by mixing the above-mentioned functional components with conventional daily chemical additives in the art according to the ratio provided by the present invention. The anti-hair loss composition is conventionally shampoo, essence water, essence liquid and the like.

[0034] Another technical problem solved by the present invention is to provide a method for preparing an anti-hair loss efficacy composition, which specifically comprises the following steps:

[0035] 1. Mix water, surfactant and thickener, heat to 80±2℃, stir evenly at a stirring speed of 30±2 rpm until completely dissolved;

[0036] 2. Sterilize at 80±2℃ for 30 minutes, then cool down;

[0037] 3. Cool down to 60±2℃, add moisturizer, stir evenly, stirring at 20±2 rpm;

[0038] 4. Cool down to 40±2℃, add functional components and preservatives, stir evenly at a stirring speed of 20±2 rpm;

[0039] 5. Filter through a 100-mesh sterilized dry filter cloth to remove impurities to obtain the anti-hair loss composition.

[0040] (III) Beneficial effects

[0041] Compared with the prior art, the present invention provides a composition with anti-hair loss efficacy and a preparation method and application thereof, which have the following beneficial effects:

[0042] The present invention provides an anti-hair loss efficacy composition, which includes: Platycladus orientalis leaf extract, ginger root extract, lotus leaf extract, Rehmannia root extract, caffeine, and schizophyllan. Among them, the extracts of lotus leaf and Rehmannia root can regulate oil balance, control oil and resist lipid oxidation, fundamentally solve the scalp oil secretion disorder and vigorous oil secretion, and reduce the harmful substances produced by oil oxidation that damage hair follicle cells. Platycladus orientalis leaf is a traditional anti-hair loss and hair growth Chinese medicinal material. The Platycladus orientalis leaf extract of the present invention adopts a three-directional enrichment process to enrich the anti-hair loss efficacy components of Platycladus orientalis leaf and enhance its effect of promoting hair growth. The added caffeine can inhibit the activity of 5α-reductase, reduce the damage of dihydrotestosterone (DHT) to hair follicles, and then promote the healthy growth of hair follicles. It can also activate capillary microcirculation and improve nutrient supply. The ginger root extract has the effect of promoting blood circulation and accelerating the supply of nutrients. Different molecular weights of schizophyllan can soothe and repair damaged scalp, strengthen the scalp's barrier protection, help the scalp to effectively metabolize and renew, and maintain and improve the health of the scalp.

[0043] This anti-hair loss efficacy composition solution comprehensively solves the scalp health problems caused by hair loss through the multi-dimensional effects of oil control and anti-oxidation, hair growth promotion, blood circulation promotion, and hair nutrition and strengthening. BRIEF DESCRIPTION OF THE DRAWINGS

[0044] Figure 1 This is a data chart of the oil control and anti-hair loss efficacy test of the example samples of the present invention;

[0045] Figure 2 , Figure 3 and Figure 4The data graphs of the changes in the density of hair follicles at the hair loss sites on the heads of three groups of subjects of the present invention are as follows;

[0046] Figure 5 , Figure 6 and Figure 7 The data graph of the number of hair loss when combing the hair of three groups of subjects of the present invention; DETAILED DESCRIPTION

[0047] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0048] See also Figure 1-7 Embodiment 1: The anti-hair loss efficacy composition is characterized in that the efficacy components include: 20% THUJA ORIENTALIS leaf extract, 2% ZINGIBER OFFICINALE root extract, 5% NELUMBO NUCIFERA leaf extract, 10% REHMANNIA GLUTINOSA root extract, 0.5% caffeine, and 10% schizophyllan; the conventional daily chemical additive components include: surfactant: 17% sodium laureth sulfate, 2% cocamidopropyl betaine, and 1% cetearyl glucoside; humectant: 4% glycerol, 2% erythritol, and 2% hydroxyethyl urea; thickener: 0.5% sodium carbomer, 0.5% PEG-120 methyl glucose dioleate; preservative: 0.3% DMDM ​​hydantoin, 0.4% sodium benzoate, and the balance is water.

[0049] Embodiment 2: The anti-hair loss efficacy composition is characterized in that the efficacy components include: 2% Thuja orientalis leaf extract, 0.1% ginger root extract, 0.1% nelumbo nucifera leaf extract, 1% rehmannia root extract, 0.1% caffeine, and 0.5% schizophyllan; the conventional daily chemical additive components include: 0.8% cetearyl glucoside and 0.2% ceteareth-20; humectants include 0.5% erythritol, 1% hydroxyethyl urea, and 0.5% panthenol; thickeners include 0.1% xanthan gum and 0.1% hydroxyethyl cellulose; preservatives include 0.1% methylparaben, 0.1% phenoxyethanol, and 0.1% chlorphenesin; and the balance is water.

[0050] Embodiment 3: The anti-hair loss efficacy composition is characterized in that the efficacy components include: 10% Thuja orientalis leaf extract, 1% ginger root extract, 2% nelumbonucifera leaf extract, 5% rehmannia root extract, 0.3% caffeine, and 5% schizophyllan; the conventional daily chemical additive components include: surfactant: 2% cetearyl glucoside, 1% glyceryl stearate, and 1% PEG-100 stearate; humectant: 2% butylene glycol, 2% squalane, 1% olive oil, and 1% hydroxyethyl urea; thickener: 0.3% acrylic acid (ester) / C10-30 alkyl acrylate cross-linked polymer, and 0.2% xanthan gum; preservative: 0.2% p-hydroxyacetophenone, 0.2% phenoxyethanol, and 0.1% chlorphenesin, and the balance is water.

[0051] Example sample oil control and anti-hair loss efficacy test:

[0052] 1. Oil control efficacy testing method: 5α-reductase inhibition method.

[0053] 5α-reductase can convert testosterone in the human body into dihydrotestosterone (DHT). DHT can induce excessive secretion of oil by the sebaceous glands. Excess oil oxidizes and damages the hair follicles, thus causing hair loss. The 5α-reductase activity inhibition rate is used to test whether the test substance has the ability to inhibit excessive secretion of oil by the sebaceous glands. The higher the 5α-reductase inhibition rate, the better the oil control effect of the sample and the better the effect of assisting in preventing hair loss.

[0054] Test method:

[0055] (1) The standard control substance is a blank control group without the active component. 0.1 ml of sample solution of the same concentration is added to the sample tube and sample background, and 0.5 mg of enzyme preparation is added to the experimental sample tube, sample blank control, enzyme reaction tube and enzyme blank.

[0056] (2) Add 0.1 ml of testosterone solution to the experimental sample tube and enzyme reaction tube, respectively; add 0.1 ml of reduced coenzyme II (NADPH) solution and 2.0 ml of phosphate buffer (pH = 6.0) to the sample tube, sample blank control, enzyme reaction tube and enzyme blank, respectively; incubate in a constant temperature water bath at 37°C for 1 hour.

[0057] (3) Add phosphate buffer (pH = 6.0) to the experimental sample tube, sample blank control, enzyme reaction tube and enzyme blank respectively, and adjust the volume to 5 ml; centrifuge at a speed of 12000 rpm for 5 minutes, take the supernatant and filter it with a 0.45 um filter membrane.

[0058] (4) Transfer each reaction solution into a 1 cm cuvette, measure the absorbance under 340 nm ultraviolet light, and then calculate the concentration of each sample.

[0059] (5) Calculation of 5α-reductase inhibition rate: inhibition rate = (control group product concentration - experimental group product concentration) / control group product concentration × 100%, wherein the control group is a group without added efficacy components, and the experimental group is a group with added efficacy components.

[0060] Example test data such as Figure 1 shown.

[0061] The concentrations of the experimental groups after adding enzymes in the examples were all reduced. The inhibition rates of 5α-reductase in Examples 1, 2 and 3 were 64.13%, 46.07% and 51.61%, respectively, indicating that the examples can effectively inhibit the activity of 5α-reductase, balance oil secretion, and have a good auxiliary effect of oil control and anti-hair loss.

[0062] 2. Anti-hair loss efficacy testing methods: hair follicle density detection method and fallen hair counting method.

[0063] The hair follicle analyzer is used to detect the changes in the density of hair follicles in the subjects' hair loss areas, as well as the changes in the number of hair lost by the subjects, which can characterize the effect of preventing hair loss and promoting hair growth before and after using the product.

[0064] Test method:

[0065] (1) Subject requirements:

[0066] Thirty subjects, including 15 males and 15 females, aged between 25 and 55 years old, were divided into Group A, Group B, and Group C, with 10 subjects in each group. Among them, the male hair loss grade was II-IV, and the female hair loss grade was I or II.

[0067] Classification of male hair loss levels:

[0068] Type I: normal or almost normal hair style;

[0069] Type II: The frontotemporal hairline moves back in a triangular shape, about 2 cm away from the coronal line connecting the two ear canals;

[0070] Type III: The two temporal horns retract beyond 2 cm in front of the coronal line, and the top is sparse;

[0071] Type IV: The hairline on both temples and forehead is obviously receding, and the hairline in the middle of the forehead is receding, separated by a medium-density hair band;

[0072] Type V: frontotemporal and parietal bare areas are enlarged, with narrow and sparse hair bands in between;

[0073] Type VI: horseshoe-shaped hair loss with increasing areas of hair loss on the sides and back;

[0074] Type VII: A severe form with hair loss around the ears and occipital area in addition to horseshoe-shaped hair loss.

[0075] Female hair loss classification:

[0076] Type I: The hair in the front of the crown area is thinning, and the hairstyle must be changed to cover it up, and the frontal hairline is intact;

[0077] Type II: The thinning of the hair in the front part of the coronal area is more obvious, the area of ​​hair loss is wider, and it is difficult to conceal it by changing the hairstyle;

[0078] Type III: The top of the head is completely bald or bare, but the forehead hairline is still intact.

[0079] (2) Usage:

[0080] The three groups of subjects, A, B, and C, used the samples of Examples 1-3 respectively, once in the morning and once in the evening, taking 10 ml (rinse) or 3 ml (retention) of the sample each time, for 2 consecutive months. During the test, no other cosmetics, drugs, or health products that may affect the results were used.

[0081] (3) Data testing:

[0082] A 4 cm x 4 cm detection area was selected at the hair loss site of the three groups of subjects. The hair follicle analyzer was used to photograph the detection area of ​​the subjects at week 0, 2, 4, 6, and 8. The changes in hair follicle density were statistically analyzed and the average value was taken. The results are shown in Figure 2 , Figure 3 , Figure 4 .

[0083] The number of hairs lost by the subjects when combing their hair was collected. The number of hairs lost by the subjects after using the product for the 0th and 8th weeks was collected. The specific method of each collection was: combing the hair on a double-layer gauze of 1 meter square, collecting and counting the hair attached to the gauze. The results are shown in Figure 5 , Figure 6 , Figure 7 .

[0084] (4) Data calculation:

[0085] As can be seen from the figure, after using the samples of Examples 1-3 for 8 weeks, the effective hair follicle density of the three groups of subjects increased significantly. The average increase in hair follicle density of the three groups of subjects was: 44.93 / cm 2 , 28.19 pieces / cm 2 , 37.25 / cm 2, the average hair follicle density growth rates were 78.02%, 48.96%, and 64.23% respectively. Moreover, as the product usage time increases, the effective hair follicle density continues to increase. This shows that the anti-hair loss efficacy composition can significantly promote the proliferation of hair follicle cells and increase the number of effective hair follicles on the scalp, thereby proving that the anti-hair loss efficacy composition has an effective anti-hair loss effect.

[0086] After using the samples of Examples 1-3 for 8 weeks, the amount of hair loss of the subjects was significantly reduced compared with that before use (week 0), and the hair loss reduction rates of the three groups of subjects were 70.34%, 53.31%, and 62.28%, respectively. This shows that the anti-hair loss efficacy composition can improve the hair loss situation of product users to varying degrees and has an effective anti-hair loss efficacy.

[0087] In summary, the samples of the anti-hair loss efficacy composition of the present invention all have the effects of controlling oil, promoting hair follicle cell proliferation, and improving hair loss. The anti-hair loss efficacy composition of the present invention prevents hair loss and hair loss in multiple dimensions through oil control, anti-oxidation, hair growth promotion, blood circulation promotion, and hair nutrition, and comprehensively solves the scalp health problems of consumers' hair loss.

[0088] In order to explain in detail the possible application scenarios, technical principles, specific schemes that can be implemented, and the purposes and effects that can be achieved, the following is a detailed description of the specific embodiments listed in conjunction with the accompanying drawings. The embodiments described herein are only used to more clearly illustrate the technical solutions of the present application, and are therefore only used as examples, and cannot be used to limit the scope of protection of the present application.

[0089] Reference to "embodiment" herein means that the specific features, structures or characteristics described in conjunction with the embodiment may be included in at least one embodiment of the present application. The term "embodiment" appearing in various places in the specification does not necessarily refer to the same embodiment, nor does it particularly limit its independence or association with other embodiments. In principle, in the present application, as long as there is no technical contradiction or conflict, the various technical features mentioned in the embodiments can be combined in any way to form a corresponding implementable technical solution.

[0090] Unless otherwise defined, the technical terms used in this document have the same meanings as those generally understood by those skilled in the art to which this application belongs; the use of relevant terms in this document is only for describing specific embodiments and is not intended to limit this application.

[0091] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A composition with multi-dimensional anti-hair loss efficacy, comprising an efficacy component, a conventional daily chemical additive component and water, characterized in that: The functional components, conventional daily chemical additive components and water include the following components in mass percentage: the functional components are 2-20% of Thuja Orientalis leaf extract, 0.1-2% of Zingiber Officinale root extract, 0.1-5% of Nelumbo Nucifera leaf extract, 1-10% of Rehmannia Glutinosa root extract, 0.1-0.5% of caffeine and 0.5-10% of schizophyllan; the conventional daily chemical additive components can be selected from 1-20% of surfactant, 2-8% of moisturizer, 0.2-1% of thickener and 0.3-0.7% of preservative, and the balance is water.

2. The Platycladus orientalis leaf extract in the anti-hair loss composition according to claim 1 is prepared by using a three-directional enrichment process of enzymatic hydrolysis, alcohol extraction, and ultrasonic extraction to specifically enrich the components of the Platycladus orientalis leaf that have an anti-hair loss effect.

3. According to the anti-hair loss composition of claim 1, the schizophyllan in the anti-hair loss composition is preferably a schizophyllan with a large molecular weight of 6 million to 10 million Daltons (content of 60-80%) and a schizophyllan with a small molecular weight of 2000 to 5000 Daltons (content of 20-40%) for efficacy matching.

4. The conventional daily chemical additives in the anti-hair loss composition according to claim 1 include one or a mixture of the following surfactants, humectants, thickeners, and preservatives: Optional, surfactants: sodium laureth sulfate, cocamidopropyl betaine, cetearyl glucoside, ceteareth-20, glyceryl stearate, PEG-100 stearate, cetyl PEG / PPG-10 / 1 dimethicone; Optional, humectants: glycerin, propylene glycol, butylene glycol, hexylene glycol, squalane, olive oil, erythritol, hydroxyethyl urea, panthenol; Optional, thickener: sodium carbomer, acrylates / C10-30 alkyl acrylate crosspolymer, acrylates copolymer, xanthan gum, hydroxyethyl cellulose, hydroxypropyl methylcellulose, PEG-150 pentaerythritol tetrastearate, PEG-120 methyl glucose dioleate; Optional, preservatives: hydroxyacetophenone, methylparaben, propylparaben, phenoxyethanol, sodium benzoate, benzyl alcohol, chlorphenesin, DMDM ​​hydantoin.

5. The anti-hair loss composition according to claim 1 is characterized in that: The effective components include: 20% THUJA ORIENTALIS leaf extract, 2% ZINGIBER OFFICINALE root extract, 5% NELUMBO NUCIFERA leaf extract, 10% REHMANNIA GLUTINOSA root extract, 0.5% caffeine, and 10% schizophyllan; the conventional daily chemical additive components may include 20% surfactant, 8% humectant, 1% thickener, 0.7% preservative, and the balance is water. The effective components include: 2% THUJA ORIENTALIS leaf extract, 0.1% ZINGIBER OFFICINALE root extract, 0.1% NELUMBO NUCIFERA leaf extract, 1% REHMANNIA GLUTINOSA root extract, 0.1% caffeine, and 0.5% schizophyllan; the conventional daily chemical additive components may include: 1% surfactant, 2% humectant, 0.2% thickener, 0.3% preservative, and the balance is water. The effective components include: 10% THUJA ORIENTALIS leaf extract, 1% ZINGIBER OFFICINALE root extract, 2% NELUMBO NUCIFERA leaf extract, 5% REHMANNIA GLUTINOSA root extract, 0.3% caffeine, and 5% schizophyllan; the conventional daily chemical additive components may include 4% surfactant, 6% humectant, 0.5% thickener, 0.5% preservative, and the balance is water.

6. The anti-hair loss composition according to claim 1, wherein the preparation method thereof comprises the following steps: (1) Mix water, surfactant and thickener, heat to 80±2°C, stir evenly at a stirring speed of 30±2 rpm until completely dissolved; (2) Sterilize at 80±2℃ for 30 minutes, then cool down; (3) Cool down to 60±2°C, add moisturizer, and stir evenly at a stirring speed of 20±2 rpm; (4) Cool down to 40±2°C, add functional components and preservatives, and stir evenly at a stirring speed of 20±2 rpm; (5) filtering with a 100-mesh sterilized dry filter cloth to remove impurities, thereby obtaining the anti-hair loss composition.

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