An amikacin composition effective to inhibit pseudomonas aeruginosa biofilm bacteria

The combination of N-(3-cyclobutyrolactone)-4-nitrophenylbutyramide and amikacin enhances the sensitivity of Pseudomonas aeruginosa biofilms to antibiotics, solving the problem of drug resistance caused by biofilms and achieving effective treatment of chronic infections.

CN119868384BActive Publication Date: 2026-06-23LANZHOU UNIV
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Patent Information

Application Number
CN202510078370.5
Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
Filing Date
2025-01-17
Publication Date
2026-06-23
Estimated Expiration
2045-01-17

AI Technical Summary

Technical Problem

Existing antibiotics are ineffective against Pseudomonas aeruginosa biofilms, leading to chronic infections that are difficult to cure. The formation of biofilms significantly reduces the bacteria's sensitivity to antibiotics.

Method used

A combination of N-(3-cyclobutyrolactone)-4-nitrophenylbutyramide and amikacin was used to enhance the sensitivity of biofilm bacteria to antibiotics and inhibit biofilm formation.

Benefits of technology

It significantly increases the susceptibility of Pseudomonas aeruginosa to amikacin, reduces the amount of biofilm formation, and effectively prevents chronic infection by drug-resistant Pseudomonas aeruginosa.

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Abstract

The application discloses an N-(3-cyclobutyrolactone)-4-nitrophenyl butyryl amide and amikacin composition and application of the composition in treating chronic infection of drug-resistant bacteria. After the N-(3-cyclobutyrolactone)-4-nitrophenyl butyryl amide and the amikacin are combined, not only the sensitivity of pseudomonas aeruginosa to the amikacin can be obviously increased, but also the formation amount of the pseudomonas aeruginosa biofilm can be greatly reduced, so that the composition can be applied to preventing and treating chronic infection of drug-resistant pseudomonas aeruginosa.
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