Curcumin composition

Abstract

The invention discloses a curcumin composition, which belongs to the technical field of pharmaceutical preparations and comprises the following raw materials in parts by mass: 3 to 15 parts of curcumin, 0.5 to 2 parts of octenyl succinic anhydride tartary buckwheat dextrin ester, 0.4 to 5 parts of light-resistant antioxidant, 1 to 5 parts of sialic acid and 10 to 20 parts of carmine radish red pigment extract. The curcumin composition disclosed by the invention has better water solubility, oxidation resistance and light stability, and is more beneficial to being applied to anti-oxidation treatment.

Description

Technical Field

[0001] The present invention relates to the technical field of pharmaceutical preparations, and more specifically, to a curcumin composition. Background Art

[0002] Curcumin is a natural polyphenol compound with good antioxidant and anti-inflammatory properties. It can convert reactive oxygen species (such as superoxide anion O) into 2 - Curcumin itself is an acidic phenolic substance. Its structural characteristics lead to its poor water solubility and unstable properties (easily decomposed by light). During storage, production and application, it is inevitably exposed to light sources, causing partial decomposition of curcumin, which brings about a series of comprehensive problems of safety and effectiveness, resulting in insufficient active oxygen scavenging and anti-inflammatory effects, reducing the utilization rate of curcumin and limiting its application in antioxidant therapy. Summary of the invention

[0003] The object of the present invention is to overcome the deficiencies of the prior art and provide a curcumin composition.

[0004] In order to achieve the above object, the present invention adopts the following technical solution:

[0005] A curcumin composition comprises the following raw materials in parts by weight: 3-15 parts of curcumin, 0.5-2 parts of octenylsuccinic anhydride tartary buckwheat dextrin ester, 0.4-5 parts of a photostable antioxidant, 1-5 parts of bird's nest acid, and 10-20 parts of a carmine red pigment extract.

[0006] The present invention is further configured such that the light-stable antioxidant is at least one of natural pigments having water solubility, light resistance and antioxidant properties.

[0007] The present invention is further configured such that the light-stable antioxidant is at least one of ganoderma lucidum pigment and chrysanthemum chrysanthemum pigment.

[0008] The present invention is further configured that the curcumin composition is prepared by the following method:

[0009] a. Evenly mix bird's nest acid and rouge radish red pigment extract, add curcumin ground into nanoparticles and mix thoroughly to obtain a primary mixture;

[0010] b. Add octenyl succinic anhydride bitter buckwheat dextrin ester and light-resistant antioxidant to the primary mixture, stir and mix, and obtain a curcumin composition.

[0011] The present invention is further configured as follows: washing and chopping the roux radish to squeeze out the roux radish juice, using water to extract the red pigment in the roux radish residue, filtering, and concentrating the filtrate to a viscous state through vacuum rotary evaporation to obtain the roux radish red pigment extract.

[0012] The present invention is further configured that the filtrate is rotary evaporated to 5-12% of the initial volume to obtain the annatto red pigment extract.

[0013] The present invention is further configured that the particle size of the curcumin nanoparticles is 15-30 nm.

[0014] The present invention is further configured to include the following raw materials in parts by mass: 10 parts of curcumin, 1 part of octenylsuccinic anhydride bitter buckwheat dextrin ester, 3 parts of ganoderma lucidum pigment, 3 parts of saccharic acid, and 15 parts of rouge radish red pigment extract.

[0015] The present invention is further configured as follows: adding chrysanthemum chrysanthemum flowers to water, adjusting the pH value to 5 with sodium hydroxide solution, and controlling the solid-liquid ratio to 1:20, then extracting at 50°C for 5 hours, filtering, rotary evaporating and concentrating the obtained filtrate, and then spray-drying the concentrated solution to obtain chrysanthemum chrysanthemum pigment.

[0016] In summary, the present invention has the following beneficial effects:

[0017] By compounding octenylsuccinic anhydride buckwheat dextrin ester, photostable antioxidant, sialic acid, annatto red pigment and curcumin, a curcumin composition with good water solubility, antioxidant property and photostability is obtained; and ganoderma lucidum pigment, sialic acid, annatto red pigment extract and octenylsuccinic anhydride buckwheat dextrin ester can play a synergistic role, thereby improving the antioxidant property and photostability of the curcumin composition, which is conducive to broadening its application in antioxidant therapy. DETAILED DESCRIPTION

[0018] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0019] The curcumin composition of the present invention comprises the following raw materials in parts by mass: 3-15 parts of curcumin, 0.5-2 parts of octenylsuccinic anhydride bitter buckwheat dextrin ester, 0.4-5 parts of a photostable antioxidant (the photostable antioxidant is at least one of natural pigments with water solubility, photostability and antioxidant properties, and more preferably at least one of ganoderma lucidum pigment and chrysanthemum pigment; chrysanthemum flowers are added to water, the pH value is adjusted to 5 with a sodium hydroxide solution, and the solid-liquid ratio is controlled to be 1:20, and then the water is extracted at 50°C for 5h, filtered, the obtained filtrate is concentrated by rotary evaporation, and the concentrated solution is spray-dried to obtain chrysanthemum pigment), 1-5 parts of bird's nest acid, and 10-20 parts of rouge radish red pigment extract.

[0020] The curcumin composition is prepared by the following method:

[0021] a. Wash and chop the rouge radish, squeeze out the rouge radish juice, extract the red pigment in the rouge radish residue with water (the mass ratio of water to rouge radish residue is 1:1, and the extraction time is 8 hours), filter, and concentrate the filtrate to a viscous state by vacuum rotary evaporation (rotary evaporation to 5-12% of the initial volume) to obtain the rouge radish red pigment extract; mix sialic acid and the rouge radish red pigment extract evenly, add curcumin ground into nanoparticles (particle size is 15-30nm), and mix them thoroughly to obtain a primary mixture.

[0022] In this step, bird's nest acid (N-acetylneuraminic acid) is purchased from Shanghai Yunluo Biotechnology Co., Ltd. It has excellent light stability and thermal stability and will not lose its effectiveness due to light and temperature. The carmine red pigment extract is a viscous substance, and curcumin can be effectively coated after adding curcumin particles; in addition, the carmine red pigment extract contains a small amount of water, and bird's nest acid is added to the carmine red pigment extract to combine with water to form a viscous substance. The curcumin particles can also be coated by the carmine red pigment extract and the bird's nest acid viscous substance, which can effectively prevent the light degradation of curcumin. Bird's nest acid is water-absorbent, and the amount of bird's nest acid added is controlled to absorb the water in the carmine red pigment extract as much as possible.

[0023] b. Add octenyl succinic anhydride tartary buckwheat dextrin ester and a light-stable antioxidant to the initial mixture, stir and mix to obtain a curcumin composition. Octenyl succinic anhydride tartary buckwheat dextrin ester is prepared according to the method in the paper "Study on the Self-aggregation Characteristics of Octenyl Succinic Acid Tartary Buckwheat Dextrin Ester" (Zou Yan, Dong Nan, Shi Bingyan, Lu Yang, Food Science and Technology, Food Science and Technology. 2023, 48 (07)).

[0024] Preferred embodiment 1

[0025] a. Wash and chop the rouge radish, squeeze out the rouge radish juice, extract the red pigment in the rouge radish residue with water (the mass ratio of water to rouge radish residue is 1:1, and the extraction time is 8 hours), filter, and concentrate the filtrate to a viscous state by vacuum rotary evaporation (rotary evaporation to 8% of the initial volume) to obtain the rouge radish red pigment extract; mix sialic acid and the rouge radish red pigment extract evenly, add curcumin ground into nanoparticles (particle size is 15-30nm), and mix well to obtain a primary mixture;

[0026] b. Add octenylsuccinic anhydride tartary buckwheat dextrin ester and ganoderma lucidum pigment to the initial mixture, stir and mix, and obtain a curcumin composition. The curcumin composition comprises the following raw materials in parts by weight: 10 parts of curcumin, 1 part of octenylsuccinic anhydride tartary buckwheat dextrin ester, 3 parts of chrysanthemum pigment, 3 parts of scutellaria baicalensis pigment, and 15 parts of rouge radish red pigment extract.

[0027] Comparative Example 1

[0028] The curcumin composition was prepared according to the method of Example 1, but without adding Ganoderma lucidum pigment.

[0029] Comparative Example 2

[0030] The curcumin composition was prepared according to the method of Example 1, but without adding bird's nest acid.

[0031] Comparative Example 3

[0032] A curcumin composition was prepared according to the method of Example 1, but without adding the annatto pigment extract.

[0033] Comparative Example 4

[0034] The curcumin composition was prepared according to the method of Example 1, but without adding octenyl succinic anhydride tartary buckwheat dextrin ester.

[0035] Example 2

[0036] The curcumin composition was prepared according to the method of Example 1, except that the mass of Ganoderma lucidum pigment was replaced by Chrysanthemum chrysanthemum pigment.

[0037] The curcumin compositions prepared in Examples 1 to 2 and Comparative Examples 1 to 4 were respectively measured for antioxidant properties, and the scavenging rates of DPPH radicals were calculated. The results showed that the DPPH radical scavenging rates of the curcumin compositions in Examples 1 to 2 and Comparative Examples 1 to 4 were 95.1%, 90.3%, 85.5%, 83.4%, 80.7% and 83.6%, respectively.

[0038] The curcumin compositions prepared in Examples 1 to 2 and Comparative Examples 1 to 4 were placed in a light box with an illumination of 4500 ± 500 lx for a light stability test, and samples were taken at regular intervals to determine the change in the content of curcumin in each composition. After 20 days of illumination, the contents of curcumin in the curcumin compositions prepared in Examples 1 to 2 and Comparative Examples 1 to 4 were 90.4%, 82.1%, 77.3%, 75.2%, 70.4%, and 86.5% of the initial content, respectively.

[0039] In addition, the curcumin compositions prepared in Example 1, Comparative Example 2, and Comparative Example 4 were added to water to form saturated solutions, and the saturated aqueous solution of the pure curcumin raw material was used as a control, and the solubility of curcumin in each saturated solution was measured and calculated using an ultraviolet-visible spectrophotometer. The results show that the solubility of curcumin in the saturated solution of the curcumin composition of Example 1, Comparative Example 2, and Comparative Example 4 is 91 times, 85 times, and 53 times the maximum solubility of curcumin in the saturated aqueous solution of the pure curcumin raw material.

[0040] From the above results, it can be seen that the curcumin composition of the present invention has good water solubility, antioxidant properties and light stability; and there is a synergistic effect between Ganoderma lucidum pigment, saccharin, rouge radish red pigment extract, and octenyl succinic anhydride buckwheat dextrin ester, which can further enhance its antioxidant properties and light resistance.

[0041] The above is only a preferred embodiment of the present invention, and the protection scope of the present invention is not limited to the above embodiments. All technical solutions under the concept of the present invention belong to the protection scope of the present invention. It should be pointed out that for ordinary technicians in this technical field, some improvements and modifications without departing from the principle of the present invention should also be regarded as the protection scope of the present invention.

Claims

1. A curcumin composition, characterized in that The invention comprises the following raw materials in parts by weight: 3-15 parts of curcumin, 0.5-2 parts of octenylsuccinic anhydride bitter buckwheat dextrin ester, 0.4-5 parts of light-resistant antioxidant, 1-5 parts of bird's nest acid and 10-20 parts of rouge radish red pigment extract.

2. A curcumin composition according to claim 1, characterized in that, The light-stable antioxidant is at least one of natural pigments that are water-soluble, light-stable and anti-oxidative.

3. A curcumin composition according to claim 1, characterized in that, The light-resistant antioxidant is at least one of ganoderma pigment and chrysanthemum pigment.

4. A curcumin composition according to any one of claims 1 to 3, characterized in that: The curcumin composition is prepared by the following method: a. Evenly mix bird's nest acid and rouge radish red pigment extract, add curcumin ground into nanoparticles and mix thoroughly to obtain a primary mixture; b. Add octenyl succinic anhydride bitter buckwheat dextrin ester and light-resistant antioxidant to the primary mixture, stir and mix, and obtain a curcumin composition.

5. A curcumin composition according to claim 4, characterized in that, Wash and chop the roux radish, squeeze out the roux radish juice, extract the red pigment in the roux radish residue with water, filter, and concentrate the filtrate to a viscous state by vacuum rotary evaporation to obtain the roux radish red pigment extract.

6. A curcumin composition according to claim 5, characterized in that: The filtrate is rotary evaporated to 5-12% of the initial volume to obtain the annatto red pigment extract.

7. A curcumin composition according to claim 4, characterized in that: The particle size of curcumin nanoparticles is 15-30nm.

8. A curcumin composition according to claim 1, characterized in that: The invention comprises the following raw materials in parts by weight: 10 parts of curcumin, 1 part of octenylsuccinic anhydride bitter buckwheat dextrin ester, 3 parts of ganoderma lucidum pigment, 3 parts of saccharic acid, and 15 parts of rouge radish red pigment extract.

9. A curcumin composition according to claim 4, characterized in that: Add chrysanthemum chrysanthemum flowers to water, adjust the pH value to 5 with sodium hydroxide solution, and control the solid-liquid ratio to 1:20, then extract at 50°C for 5 hours, filter, concentrate the filtrate by rotary evaporation, and then spray-dry the concentrated solution to obtain chrysanthemum chrysanthemum pigment.