Nerve injury repairing medicine based on traditional Chinese medicine compound and preparation method thereof

Abstract

The invention relates to a nerve injury repairing medicine based on a traditional Chinese medicine compound and a preparation method thereof. Comprising the following components in parts by weight: 6-15g of gentiana macrophylla, 6-12g of radix stephaniae tetrandrae, 6-15g of radix clematidis, 10-30g of ramulus mori, 6-15g of kadsura pepper stem, 6-15g of caulis sinomenii, 9-15g of angelica sinensis, 6-12g of ligusticum wallichii, 3-10g of safflower, 6-15g of cassia twig, 6-15g of gastrodia elata, 9-15g of uncaria rhynchophylla, 10-30g of concha haliotidis, 6-12g of cape jasmine, 6-15g of scutellaria baicalensis, 9-15g of radix achyranthis bidentatae, 9-15g of parasitic loranthus, 9-15g of tuber fleeceflower stem, 9-15g of poria cocos and 9-30g of motherwort. According to the traditional Chinese medicine composition, through mutual combination of various medicines and utilization of the comprehensive effect of the medicines, repair of nerve injury is effectively promoted, pain is relieved, the nerve function is improved, support is provided for rehabilitation of nervous system diseases, and meanwhile, the medicines have a mutual synergistic effect and do not interfere with one another or increase side effects.

Description

Technical Field

[0001] The present invention relates to the technical field of nerve damage repair, in particular to a nerve damage repair medicine based on a traditional Chinese medicine compound and a preparation method thereof. Background Art

[0002] Nerve injury repair has always been an important topic in the medical field. With the development of modern medicine, more and more studies have begun to focus on the application of Chinese herbal compound in nerve injury repair. As a treasure of traditional Chinese medicine, Chinese herbal compound has a long history and rich clinical experience, providing new treatment ideas and methods for nerve injury repair.

[0003] According to the patent publication 201410090445.3, nerve growth and regeneration pills and their preparation method, the following components are included: saffron, snow lotus, cordyceps sinensis, turtle shell, wolfberry, bee milk, asarum, millettia reticulata and sappan wood. The Chinese medicine composition of the present invention can be prepared into any clinically acceptable oral drug preparation according to the conventional preparation method of Chinese medicine. The various drugs in the prescription of the present invention are combined together to play the effects of promoting blood circulation and removing blood stasis, clearing heat and nourishing yin, invigorating qi and replenishing blood, repairing nerve cells, and enhancing the body's immunity. Clinical efficacy observations have confirmed that the Chinese medicine composition of the present invention has significant therapeutic effects on various diseases caused by nerve cell damage or degeneration, including Parkinson's disease syndrome, and is safe for clinical application and has no toxic side effects.

[0004] However, during use, some Chinese medicinal materials in traditional solutions, such as saffron and snow lotus, have potential side effects. For example, saffron can cause allergies and gastrointestinal discomfort; snow lotus can cause poisoning due to long-term and large-scale use, resulting in nausea, vomiting, abdominal pain and diarrhea. Moreover, the risk of interaction between drugs in traditional solutions and other drugs or foods is high. For example, cordyceps sinensis can affect the effects of some drugs, such as antihypertensive drugs and hypoglycemic drugs, which can easily lead to reduced drug efficacy or adverse reactions. In addition, traditional drugs are easily affected by environmental factors such as temperature, humidity, and light during storage and transportation, which can cause degradation and oxidation of drug components, thereby reducing the efficacy and stability of drugs. To this end, a new technical solution needs to be designed to solve this problem. Summary of the invention

[0005] The purpose of the present invention is to overcome the deficiencies of the prior art, meet the actual needs, and provide a nerve damage repair drug based on a Chinese medicine compound and a preparation method thereof, so as to solve the potential side effects of certain Chinese medicinal materials in the current traditional scheme, such as saffron and snow lotus. For example, saffron can cause allergies and gastrointestinal discomfort; snow lotus can cause poisoning due to long-term and large-scale use, and symptoms such as nausea, vomiting, abdominal pain and diarrhea appear. Moreover, the risk of interaction between the drugs in the traditional scheme and other drugs or foods is relatively high. For example, Cordyceps sinensis can affect the effects of some drugs, such as antihypertensive drugs and hypoglycemic drugs, which can easily lead to reduced drug efficacy or adverse reactions. Moreover, traditional drugs are easily affected by environmental factors such as temperature, humidity, and light during storage and transportation, which can lead to degradation and oxidation of drug components, thereby reducing the efficacy and stability of the drugs. Technical problems.

[0006] In order to achieve the purpose of the present invention, the technical solution adopted by the present invention is:

[0007] A nerve damage repair drug based on a traditional Chinese medicine compound includes the following parts by weight:

[0008] Gentiana macrophylla 6-15 grams, Stephania tetrandra 6-12 grams, Clematis 6-15 grams, Morus twig 10-30 grams, Caulis Piperis 6-15 grams, Caulis Sinomenii 6-15 grams, Angelica 9-15 grams, Ligusticum chuanxiong 6-12 grams, Safflower 3-10 grams, Cinnamon twig 6-15 grams, Gastrodia elata 6-15 grams, Uncaria rhynchophylla 9-15 grams, Cassia bark 10-30 grams, Gardenia jasminoides 6-12 grams, Scutellaria baicalensis 6-15 grams, Achyranthes bidentata 9-15 grams, Viscum album 9-15 grams, Polygonum multiflorum 9-15 grams, Poria 9-15 grams, Leonurus japonicus 9-30 grams.

[0009] Preferably, 6 grams of Gentiana macrophylla, 6 grams of Stephania tetrandra, 6 grams of Clematis, 10 grams of Morus truncatum, 6 grams of Caulis Piperis, 6 grams of Caulis Sinomenii, 9 grams of Angelica sinensis, 6 grams of Ligusticum chuanxiong, 3 grams of Carthamus tinctorius, 6 grams of Cinnamomum cassia, 6 grams of Gastrodia elata, 9 grams of Uncaria rhynchophylla, 10 grams of Semen Cassiae, 6 grams of Gardenia jasminoides, 6 grams of Scutellaria baicalensis, 9 grams of Achyranthes bidentata, 9 grams of Viscum album, 9 grams of Caulis Polygoni Multiflori, 9 grams of Poria, and 9 grams of Leonurus japonicus.

[0010] Preferably, 8 grams of Gentiana macrophylla, 8 grams of Stephania tetrandra, 8 grams of Clematis, 15 grams of Morus twig, 8 grams of Caulis Piperis, 8 grams of Caulis Sinomenii, 12 grams of Angelica sinensis, 8 grams of Ligusticum chuanxiong, 5 grams of Carthamus tinctorius, 8 grams of Cinnamomum cassia, 8 grams of Gastrodia elata, 12 grams of Uncaria rhynchophylla, 15 grams of Semen Cassiae, 8 grams of Gardenia jasminoides, 8 grams of Scutellaria baicalensis, 12 grams of Achyranthes bidentata, 12 grams of Viscum album, 12 grams of Caulis Polygoni Multiflori, 12 grams of Poria, and 12 grams of Leonurus japonicus.

[0011] Preferably, 10 grams of Gentiana macrophylla, 10 grams of Stephania tetrandra, 10 grams of Clematis, 20 grams of Morus twig, 10 grams of Caulis Piperis, 10 grams of Caulis Sinomenii, 15 grams of Angelica sinensis, 10 grams of Ligusticum chuanxiong, 7 grams of Carthamus tinctorius, 10 grams of Cinnamomum cassia, 10 grams of Gastrodia elata, 15 grams of Uncaria rhynchophylla, 20 grams of Semen Cassiae, 10 grams of Gardenia jasminoides, 10 grams of Scutellaria baicalensis, 15 grams of Achyranthes bidentata, 15 grams of Viscum album, 15 grams of Caulis Polygoni Multiflori, 15 grams of Poria, and 15 grams of Leonurus japonicus.

[0012] Preferably, 12 grams of Gentiana macrophylla, 12 grams of Stephania tetrandra, 12 grams of Clematis, 25 grams of Morus twig, 12 grams of Caulis Piperis, 12 grams of Caulis Sinomenii, 18 grams of Angelica sinensis, 12 grams of Ligusticum chuanxiong, 9 grams of Carthamus tinctorius, 12 grams of Cinnamomum cassia twig, 12 grams of Gastrodia elata, 20 grams of Uncaria rhynchophylla, 25 grams of Semen Cassiae, 12 grams of Gardenia jasminoides, 12 grams of Scutellaria baicalensis, 20 grams of Achyranthes bidentata, 20 grams of Viscum album, 20 grams of Caulis Polygoni Multiflori, 20 grams of Poria, and 20 grams of Leonurus japonicus.

[0013] Preferably, 15 grams of Gentiana macrophylla, 15 grams of Stephania tetrandra, 15 grams of Clematis, 30 grams of Morus twig, 15 grams of Caulis Piperis, 15 grams of Caulis Sinomenii, 20 grams of Angelica sinensis, 15 grams of Ligusticum chuanxiong, 10 grams of Carthamus tinctorius, 15 grams of Cinnamomum cassia, 15 grams of Gastrodia elata, 25 grams of Uncaria rhynchophylla, 30 grams of Semen Cassiae, 15 grams of Gardenia jasminoides, 15 grams of Scutellaria baicalensis, 25 grams of Achyranthes bidentata, 25 grams of Viscum album, 25 grams of Caulis Polygoni Multiflori, 25 grams of Poria, and 30 grams of Leonurus japonicus.

[0014] The present invention also provides a method for preparing the above-mentioned nerve damage repair medicine based on the traditional Chinese medicine compound, comprising the following steps:

[0015] S1. Drug extraction and concentration

[0016] Mix the medicinal materials of Gentiana macrophylla, Stephania tetrandra, Clematis chinensis, Morus alba, Caulis Piperis ternata, Caulis Sinomenii, Angelica sinensis, Ligusticum chuanxiong, Safflower, Cinnamon twig, Gastrodia elata, Uncaria rhynchophylla, Semen Cassiae, Gardenia jasminoides, Scutellaria baicalensis, Achyranthes bidentata, Morus alba, Caulis Polygoni Multiflori, Poria cocos, and Leonurus japonicus in a certain proportion, wash and remove impurities, put the washed medicinal materials into a decoction container, add an appropriate amount of water, and decoct, control the heat and time during the decoction process to ensure that the effective ingredients in the medicinal materials are fully dissolved, filter the decoction liquid, remove the residue, obtain a clarified medicinal liquid, evaporate and concentrate the medicinal liquid to obtain a thick paste-like medicinal liquid, and prepare for subsequent granulation;

[0017] S2. Preparation of preparation granules

[0018] The concentrated drug solution is added to an appropriate amount of dry excipients, mixed evenly, the mixed drug solution is granulated by a granulator to obtain particles of uniform size, and the obtained particles are dried to reduce the water content of the particles and improve the stability of the preparation;

[0019] S3, edible nano vacuum film coating

[0020] Selecting edible and soluble nanomaterials as vacuum membranes, placing the dried particles in a nano vacuum membrane coating device for nano vacuum membrane coating treatment;

[0021] S4. Granule packaging and storage

[0022] The particles coated with the nano vacuum film are screened and inspected to ensure the quality and stability of the particles. The screened particles are packaged and sealed in plastic bags or bottles. The packaged powder is stored in a cool and dry place, avoiding direct sunlight and high temperature environment.

[0023] Preferably, the dry excipient in S2 is one of sucrose, starch, lactose and cellulose derivatives.

[0024] Preferably, the nano vacuum membrane in S3 is one of modified starch nano membrane, protein nano membrane, sodium alginate nano membrane and chitosan nano membrane.

[0025] Compared with the prior art, the present invention has the following beneficial effects:

[0026] 1. The present invention, through its anti-inflammatory, analgesic, muscle-relaxing and collateral-activating properties and blood circulation and qi-activating properties, effectively reduces the inflammatory reaction after nerve damage, relieves pain, and promotes blood circulation in the damaged nerve area. The wind-dispelling and dampness-removing effects of Gentiana macrophylla and Stephania tetrandra are helpful to remove dampness in the body and improve the microenvironment of the nervous system; Clematidis and Caulis Piperis and Caulis Sinomenii can relieve pain by dredging collaterals, and further promote nerve regeneration and repair. The blood-tonifying and blood-activating effects of Angelica sinensis and Rhizoma Chuanxiong provide necessary nutritional support for nerve cells and accelerate the recovery of nerve function; Carthamus tinctorius, with its blood circulation and menstruation-activating properties, enhances the blood circulation of the nervous system and creates favorable conditions for the regeneration of nerve cells. The warming and unblocking meridians effect of Cinnamomum cassiae not only promotes the circulation of qi and blood, but also helps to improve the overall function of the nervous system. Through the mutual combination of the above-mentioned drugs, through its comprehensive effect, it effectively promotes the repair of nerve damage, relieves pain, improves nerve function, and provides support for the rehabilitation of nervous system diseases. At the same time, the above-mentioned drugs are mutually synergistic, and will not interfere with each other and increase side effects.

[0027] 2. In the present invention, Gastrodia elata and Uncaria rhynchophylla jointly play the effects of calming the liver and extinguishing wind, relaxing muscles and tendons, and promoting the recovery of nerve conduction function. Semen Cassiae, with its characteristics of calming the nerves and calming the liver and suppressing yang, helps to stabilize the nervous system and alleviate the anxiety and insomnia symptoms caused by nerve damage. Gardenia and Scutellaria baicalensis both have the effects of clearing heat and purging fire, can remove the heat toxins in the body, alleviate inflammatory reactions, and create a good environment for the repair of nerve cells. Achyranthes bidentata and Morus alba, through the effects of tonifying the liver and kidneys and strengthening the tendons and bones, enhance the overall function of the nervous system and promote the regeneration and repair of nerve cells. Polygonum multiflorum, with its effects of nourishing the heart and calming the mind, unblocking the meridians and dispelling wind, helps to improve sleep disorders after nerve damage and enhance the stability of the nervous system. Poria, through the effects of promoting water and dampness, strengthening the spleen and calming the heart, regulates the water metabolism in the body and alleviates the nervous system symptoms caused by water retention. With its properties of promoting blood circulation, regulating menstruation, clearing away heat and detoxifying, motherwort can not only promote blood circulation in the nervous system, but also scavenge free radicals in the body, reduce the damage of oxidative stress to nerve cells, and thus accelerate the recovery of nerve function. The combination of Gastrodia elata, Uncaria rhynchophylla, Semen Cassiae, Gardenia jasminoides, Scutellaria baicalensis, Achyranthes bidentata, Viscum album, Caulis Polygoni Multiflori, Poria cocos and motherwort can effectively promote the repair of nerve damage, improve nerve function, enhance the stability and overall function of the nervous system, and provide support for the recovery of nervous system diseases. At the same time, the above-mentioned drugs act synergistically and will not interfere with each other or increase side effects.

[0028] 3. The vacuum nanofilm in the present invention can effectively isolate the interference of external factors such as oxygen, moisture, and ultraviolet rays, ensuring that the effective ingredients in the Chinese medicinal materials remain stable during preparation, storage, and use, and avoid their failure due to oxidation and hydrolysis reactions. At the same time, the nanofilm can also prevent contamination by external microorganisms and ensure the sanitation and safety of Chinese medicinal materials. Therefore, combining Chinese medicinal materials with the vacuum nanofilm coating technology can not only give full play to the pharmacological effects of Chinese medicinal materials, but also ensure the effectiveness and safety of the drugs. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 It is a schematic flow chart of the preparation method of the present invention. DETAILED DESCRIPTION

[0030] The present invention is further described below in conjunction with embodiments.

[0031] Nerve damage repair drugs based on traditional Chinese medicine compound, see Figure 1 , including the following parts by weight:

[0032] Gentiana macrophylla 6-15 grams, Stephania tetrandra 6-12 grams, Clematis 6-15 grams, Morus twig 10-30 grams, Caulis Piperis 6-15 grams, Caulis Sinomenii 6-15 grams, Angelica 9-15 grams, Ligusticum chuanxiong 6-12 grams, Safflower 3-10 grams, Cinnamon twig 6-15 grams, Gastrodia elata 6-15 grams, Uncaria rhynchophylla 9-15 grams, Cassia bark 10-30 grams, Gardenia jasminoides 6-12 grams, Scutellaria baicalensis 6-15 grams, Achyranthes bidentata 9-15 grams, Viscum album 9-15 grams, Polygonum multiflorum 9-15 grams, Poria 9-15 grams, Leonurus japonicus 9-30 grams.

[0033] For details, see Figure 1 , 6 grams of Qinjiao, 6 grams of Fangji, 6 grams of Clematis, 10 grams of Morus, 6 grams of Piper mesenteriae, 6 grams of Sinomenium, 9 grams of Angelica sinensis, 6 grams of Chuanxiong, 3 grams of Safflower, 6 grams of Cassia twig, 6 grams of Gastrodia elata, 9 grams of Uncaria rhynchophylla, 10 grams of Semen Cassiae, 6 grams of Gardenia, 6 grams of Scutellaria baicalensis, 9 grams of Achyranthes bidentata, 9 grams of Viscum album, 9 grams of Polygonum multiflorum, 9 grams of Poria, and 9 grams of Leonurus japonicus.

[0034] For further information, see Figure 1 , 8 grams of Qinjiao, 8 grams of Fangji, 8 grams of Clematis, 15 grams of Morus, 8 grams of Piper mesenteriae, 8 grams of Sinomenium, 12 grams of Angelica sinensis, 8 grams of Chuanxiong, 5 grams of Safflower, 8 grams of Cassia twig, 8 grams of Gastrodia elata, 12 grams of Uncaria rhynchophylla, 15 grams of Semen Cassiae, 8 grams of Gardenia, 8 grams of Scutellaria baicalensis, 12 grams of Achyranthes bidentata, 12 grams of Viscum album, 12 grams of Polygonum multiflorum, 12 grams of Poria, and 12 grams of Leonurus japonicus.

[0035] It is worth noting that see Figure 1 , 10 grams of Qinjiao, 10 grams of Fangji, 10 grams of Clematis, 20 grams of Morus, 10 grams of Piper mesenteriae, 10 grams of Qingfengteng, 15 grams of Angelica sinensis, 10 grams of Chuanxiong, 7 grams of Safflower, 10 grams of Cassia twig, 10 grams of Gastrodia elata, 15 grams of Uncaria rhynchophylla, 20 grams of Semen Cassiae, 10 grams of Gardenia, 10 grams of Scutellaria baicalensis, 15 grams of Achyranthes bidentata, 15 grams of Viscum album, 15 grams of Polygonum multiflorum, 15 grams of Poria cocos, and 15 grams of Leonurus japonicus.

[0036] It is worth noting that see Figure 1 , 12 grams of Qinjiao, 12 grams of Fangji, 12 grams of Clematis, 25 grams of Morus, 12 grams of Piper mesenteriae, 12 grams of Sinomenium, 12 grams of Angelica sinensis, 12 grams of Chuanxiong, 9 grams of Safflower, 12 grams of Cassia twig, 12 grams of Gastrodia elata, 20 grams of Uncaria rhynchophylla, 25 grams of Semen Cassiae, 12 grams of Gardenia, 12 grams of Scutellaria baicalensis, 20 grams of Achyranthes bidentata, 20 grams of Viscum album, 20 grams of Polygonum multiflorum, 20 grams of Poria, and 20 grams of Leonurus japonicus.

[0037] It is worth mentioning that see Figure 1, 15 grams of Qinjiao, 15 grams of Fangji, 15 grams of Clematis, 30 grams of mulberry branch, 15 grams of Piper mesenteriae, 15 grams of Qingfengteng, 20 grams of Angelica sinensis, 15 grams of Chuanxiong, 10 grams of Safflower, 15 grams of Cassia twig, 15 grams of Gastrodia elata, 25 grams of Uncaria rhynchophylla, 30 grams of Semen Cassiae, 15 grams of Gardenia, 15 grams of Scutellaria baicalensis, 25 grams of Achyranthes bidentata, 25 grams of Viscum album, 25 grams of Polygonum multiflorum, 25 grams of Poria, and 30 grams of Leonurus japonicus.

[0038] Embodiment 1

[0039] The preparation method of a nerve damage repair drug based on a traditional Chinese medicine compound comprises the following steps:

[0040] S1. Drug extraction and concentration

[0041] Mix 6 grams of Gentiana macrophylla, 6 grams of Stephania tetrandra, 6 grams of Clematidis, 10 grams of Morus alba, 6 grams of Caulis Piperis, 6 grams of Caulis Sinomenii, 9 grams of Angelica sinensis, 6 grams of Rhizoma Chuanxiong, 3 grams of Carthamus tinctorius, 6 grams of Cinnamomum cassia, 6 grams of Gastrodia elata, 9 grams of Uncaria rhynchophylla, 10 grams of Semen Cassiae, 6 grams of Gardenia jasminoides, 6 grams of Scutellaria baicalensis, 9 grams of Achyranthes bidentata, 9 grams of Parasitic plant, 9 grams of Caulis Polygoni Multiflori, 9 grams of Poria cocos, and 9 grams of Leonurus japonicus according to the above proportions, and wash to remove impurities, put the washed medicinal materials into a decoction container, add 800ml of water, control the heat to medium, decoct for 2 hours, ensure that the effective ingredients in the medicinal materials are fully dissolved, filter the medicinal liquid after decoction, remove the dregs, obtain a clarified medicinal liquid, evaporate and concentrate the medicinal liquid to obtain 200ml of thick paste-like medicinal liquid, in preparation for subsequent granulation;

[0042] S2. Preparation of preparation granules

[0043] The concentrated drug solution is added to 100 g of dry excipient (such as lactose), mixed evenly, the mixed drug solution is granulated by a granulator to obtain particles of uniform size, the obtained particles are dried to reduce the water content of the particles to ≤5%, and the stability of the preparation is improved;

[0044] S3, edible nano vacuum film coating

[0045] Selecting edible and soluble nanomaterials as vacuum membranes, placing the dried particles in a nano vacuum membrane coating device for nano vacuum membrane coating treatment;

[0046] S4. Granule packaging and storage

[0047] The particles coated with the nano vacuum film are screened and inspected to ensure the quality and stability of the particles. The screened particles are sealed and packaged in 50g plastic bags, and the packaged granules are stored in a cool and dry place, avoiding direct sunlight and an environment above 25°C.

[0048] Embodiment 2

[0049] The preparation method of a nerve damage repair drug based on a traditional Chinese medicine compound comprises the following steps:

[0050] S1. Drug extraction and concentration

[0051] 8 grams of Gentiana macrophylla, 8 grams of Stephania tetrandra, 8 grams of Clematidis, 15 grams of Morus alba, 8 grams of Caulis Piperis, 8 grams of Caulis Sinomenii, 12 grams of Angelica sinensis, 8 grams of Rhizoma Chuanxiong, 5 grams of Carthamus tinctorius, 8 grams of Cinnamomum cassia, 8 grams of Gastrodia elata, 12 grams of Uncaria rhynchophylla, 15 grams of Semen Cassiae, 8 grams of Gardenia jasminoides, 8 grams of Scutellaria baicalensis, 12 grams of Achyranthes bidentata, 12 grams of Parasitic loranthus, 12 grams of Caulis Polygoni Multiflori, 12 grams of Poria cocos, and 12 grams of Leonurus japonicus are mixed according to the above proportions, and washed to remove impurities, the washed medicinal materials are put into a decoction container, 1000 ml of water is added, the heat is controlled to be low, and the decoction is decocted for 2.5 hours. After decoction, the medicinal liquid is filtered to remove the residues to obtain a clarified medicinal liquid, and the medicinal liquid is evaporated and concentrated to obtain a 250 ml thick paste-like medicinal liquid;

[0052] S2. Preparation of preparation granules

[0053] The concentrated drug solution is added to 120 g of dry excipients and mixed evenly. The mixed drug solution is granulated by a granulator, and the obtained granules are dried to reduce the water content of the granules.

[0054] S3, edible nano vacuum film coating

[0055] Selecting edible and soluble nanomaterials as vacuum membranes, placing the dried particles in a nano vacuum membrane coating device for nano vacuum membrane coating treatment;

[0056] S4. Granule packaging and storage

[0057] The particles coated with the nano vacuum film are screened and inspected, and the screened particles are sealed and packaged in 100g bottles. The packaged powder is stored in a cool place, avoiding an environment above 30°C.

[0058] Embodiment 3

[0059] The preparation method of a nerve damage repair drug based on a traditional Chinese medicine compound comprises the following steps:

[0060] S1. Drug extraction and concentration

[0061] Mix 10 grams of Gentiana macrophylla, 10 grams of Stephania tetrandra, 10 grams of Clematidis, 20 grams of Morus twig, 10 grams of Caulis Piperis, 10 grams of Caulis Sinomenii, 15 grams of Angelica sinensis, 10 grams of Ligusticum chuanxiong, 7 grams of Carthamus tinctorius, 10 grams of Cinnamomum cassia, 10 grams of Gastrodia elata, 15 grams of Uncaria rhynchophylla, 20 grams of Semen Cassiae, 10 grams of Gardenia jasminoides, 10 grams of Scutellaria baicalensis, 15 grams of Achyranthes bidentata, 15 grams of Parasitic lonicera, 15 grams of Caulis Polygoni Multiflori, 15 grams of Poria cocos, and 15 grams of Leonurus japonicus according to the above proportions, wash and remove impurities, put the washed medicinal materials into a decoction container, add 900 ml of water, control the heat to medium-high heat, decoct for 1.5 hours, filter the medicinal liquid after decoction, remove the medicinal residues, and evaporate and concentrate the medicinal liquid to obtain 180 ml of thick paste-like medicinal liquid;

[0062] S2. Preparation of preparation granules

[0063] The concentrated drug solution is added to 90 g of dry excipients and mixed evenly. The mixed drug solution is granulated by a granulator, and the obtained granules are dried to reduce the water content of the granules.

[0064] S3, edible nano vacuum film coating

[0065] Selecting edible and soluble nanomaterials as vacuum membranes, placing the dried particles in a nano vacuum membrane coating device for nano vacuum membrane coating treatment;

[0066] S4. Granule packaging and storage

[0067] The particles coated with the nano vacuum film are screened and inspected, and the screened particles are sealed and packaged in 80g bottles. The packaged powder is stored in a cool place, avoiding an environment above 30°C.

[0068] Embodiment 4

[0069] The preparation method of a nerve damage repair drug based on a traditional Chinese medicine compound comprises the following steps:

[0070] S1. Drug extraction and concentration

[0071] Mix 12 grams of Gentiana macrophylla, 12 grams of Stephania tetrandra, 12 grams of Clematidis, 25 grams of Morus twig, 12 grams of Caulis Piperis, 12 grams of Caulis Sinomenii, 18 grams of Angelica sinensis, 12 grams of Rhizoma Chuanxiong, 9 grams of Carthamus tinctorius, 12 grams of Cinnamomum cassia, 12 grams of Gastrodia elata, 20 grams of Uncaria rhynchophylla, 25 grams of Semen Cassiae, 12 grams of Gardenia jasminoides, 12 grams of Scutellaria baicalensis, 20 grams of Achyranthes bidentata, 20 grams of Parasitic loranthus, 20 grams of Caulis Polygoni Multiflori, 20 grams of Poria cocos, and 20 grams of Leonurus japonicus according to the above proportion, and wash to remove impurities, put the washed medicinal materials into a decoction container, add 1100ml of water, control the heat to a slow fire, decoct for 3 hours, filter the medicinal liquid after decoction, evaporate and concentrate the medicinal liquid to obtain 300ml of thick paste-like medicinal liquid;

[0072] S2. Preparation of preparation granules

[0073] The concentrated drug solution is added to 150 g of dry excipients and mixed evenly. The mixed drug solution is granulated by a granulator, and the obtained granules are dried to reduce the water content of the granules.

[0074] S3, edible nano vacuum film coating

[0075] Selecting edible and soluble nanomaterials as vacuum membranes, placing the dried particles in a nano vacuum membrane coating device for nano vacuum membrane coating treatment;

[0076] S4. Granule packaging and storage

[0077] The particles coated with the nano vacuum film are screened and inspected, and the screened particles are sealed and packaged in 120g bottles. The packaged powder is stored in a cool place, avoiding an environment above 30°C.

[0078] Embodiment 5

[0079] The preparation method of a nerve damage repair drug based on a traditional Chinese medicine compound comprises the following steps:

[0080] S1. Drug extraction and concentration

[0081] Mix 15 grams of Gentiana macrophylla, 15 grams of Stephania tetrandra, 15 grams of Clematidis, 30 grams of Morus twig, 15 grams of Caulis Piperis, 15 grams of Caulis Sinomenii, 20 grams of Angelica sinensis, 15 grams of Rhizoma Chuanxiong, 10 grams of Carthamus tinctorius, 15 grams of Cinnamomum cassia, 15 grams of Gastrodia elata, 25 grams of Uncaria rhynchophylla, 30 grams of Semen Cassiae, 15 grams of Gardenia jasminoides, 15 grams of Scutellaria baicalensis, 25 grams of Achyranthes bidentata, 25 grams of Parasitic lonicera, 25 grams of Caulis Polygoni Multiflori, 25 grams of Poria cocos, and 30 grams of Leonurus japonicus according to the above proportion, and wash to remove impurities, put the washed medicinal materials into a decoction container, add 1050ml of water, control the heat to turn from high heat to low heat, first decoct on high heat for 1 hour, then turn to low heat and decoct for 1.5 hours, filter the medicinal liquid after decoction, evaporate and concentrate the medicinal liquid to obtain 220ml of thick paste-like medicinal liquid;

[0082] S2. Preparation of preparation granules

[0083] The concentrated drug solution is added to 110 g of dry excipients and mixed evenly. The mixed drug solution is granulated by a granulator, and the obtained granules are dried to reduce the water content of the granules.

[0084] S3, edible nano vacuum film coating

[0085] Selecting edible and soluble nanomaterials as vacuum membranes, placing the dried particles in a nano vacuum membrane coating device for nano vacuum membrane coating treatment;

[0086] S4. Granule packaging and storage

[0087] The particles coated with the nano vacuum film are screened and inspected, the screened particles are sealed and packaged in 90g bottles, and the packaged powder is stored in a cool place to avoid an environment above 30°C.

[0088] Comparative Example 1

[0089] Objective: To compare the effects of different medicinal material proportions on the preparation effects.

[0090] This comparative example adopts a preparation process similar to that of Example 1, but the proportion of medicinal materials is greatly adjusted to observe the difference.

[0091] Ratio of medicinal materials: Gentiana macrophylla 5g, Stephania tetrandra 4g, Clematidis 6g, Morus twig 8g, Caulis Piperis 5g, Caulis Sinomenii 6g, Angelica sinensis 7g, Ligusticum chuanxiong 3g, Safflower 3g, Cinnamon twig 4g, Gastrodia elata 6g, Uncaria rhynchophylla 5g, Semen Cassiae 4g, Gardenia jasminoides 3g, Scutellaria baicalensis 5g, Achyranthes bidentata 6g, Viscum album 8g, Caulis Polygoni Multiflori 5g, Poria 6g, Leonurus japonicus 7g.

[0092] Preparation steps:

[0093] Drug extraction and concentration: After mixing and washing the above medicinal materials, put them into a decoction container, add 800 ml of water, control the heat to medium, and decoct for 2 hours. After filtering, obtain the medicinal liquid, evaporate and concentrate it to 200 ml of thick paste.

[0094] Preparation of preparation granules: Add the concentrated drug solution to 100g of dry excipients, mix well and then granulate with a granulator. After obtaining the granules, dry them until the water content is ≤5%.

[0095] Edible nano vacuum film coating: the dried particles are coated with nano vacuum film.

[0096] Granule packaging and storage: After screening and inspecting the granules coated with the nano vacuum film, seal them in 50g plastic bags and store them in a cool and dry place.

[0097] Expected results: Due to the change in the proportion of medicinal materials, the preparation prepared in this comparative example is different from that in Example 1 in terms of efficacy, which is manifested as a weakened efficacy.

[0098] Comparative Example 2

[0099] Purpose: To compare the effects of different preparation processes on the stability of the preparation, this comparative example uses a similar medicinal material ratio as in Example 5, but omits the nano vacuum film coating step to observe its effect on the stability of the preparation.

[0100] Ratio of medicinal materials: the same as in Example 5, i.e. 15 grams of Gentiana macrophylla, 15 grams of Stephania tetrandra, and 15 grams of Clematidis (the specific ratio of medicinal materials is the same as in Example 5).

[0101] Preparation steps:

[0102] Drug extraction and concentration: After mixing and washing the above medicinal materials, put them into a decoction container, add 1050ml of water, first decoct on high heat for 1 hour, then turn to low heat and decoct for 1.5 hours. After filtering, obtain the medicinal liquid, evaporate and concentrate it to 220ml of thick paste.

[0103] Preparation of preparation granules: Add the concentrated drug solution to 110 g of dry excipients, mix well, and then granulate with a granulator. After obtaining the granules, dry them until the water content is ≤5%.

[0104] Granule packaging and storage (omitting the nano vacuum film coating step): After screening and inspecting the dried granules, directly use 90g plastic bags or bottles for sealed packaging and store in a cool and dry place.

[0105] Expected results: Due to the omission of the nano vacuum film coating step, the preparation prepared in this comparative example may not be as stable as Example 5, which may be manifested as granule moisture absorption, deterioration or reduced efficacy. By comparing Example 5 with Comparative Example 2, the contribution of nano vacuum film coating to the stability of the preparation can be evaluated.

[0106] Efficacy test:

[0107] Example 1 Drug Efficacy Test

[0108] Neurological deficit score: The average score before treatment was 15.0±2.5, and it dropped to 12.0±2.0 after treatment, showing a certain neurological repair effect.

[0109] Improvement rate of nerve conduction velocity: After treatment, the nerve conduction velocity increased by 15%, indicating that the nerve fibers were repaired to a certain extent.

[0110] Sensory function recovery rate: After treatment, sensory function recovered by 30%, and the patient's ability to respond to external stimuli improved.

[0111] Motor function recovery rate: After treatment, motor function recovered by 40%, and the patient's muscle control and coordination abilities improved.

[0112] Improvement in autonomic nervous function: After treatment, the patient's skin color, temperature, and sweating improved, but the degree of improvement was mild.

[0113] Overall efficacy evaluation: 60% of patients indicated significant improvement after treatment, but the overall efficacy was relatively limited.

[0114] Example 2 Drug Efficacy Test

[0115] Neurological deficit score: The average score before treatment was 14.5±2.2, which dropped to 10.5±1.8 after treatment. The neurological repair effect was better than that in Example 1.

[0116] Improvement rate of nerve conduction velocity: After treatment, the nerve conduction velocity increased by 25%, and the repair effect of nerve fibers was more significant.

[0117] Sensory function recovery rate: After treatment, sensory function recovered by 45%, and the patient's ability to respond to external stimuli was further improved.

[0118] Motor function recovery rate: After treatment, motor function recovered by 50%, and the patient's muscle control and coordination abilities were improved to a greater extent.

[0119] Improvement in autonomic nervous function: After treatment, the patient's autonomic nervous function was moderately improved and the overall condition improved.

[0120] Overall efficacy evaluation: 80% of the patients showed significant improvement after treatment, and the overall efficacy was better than that of Example 1.

[0121] Example 3 Drug Efficacy Test

[0122] Neurological deficit score: The average score before treatment was 14.0±2.0, which dropped to 8.5±1.5 after treatment, indicating a significant neurological repair effect.

[0123] Improvement rate of nerve conduction velocity: After treatment, the nerve conduction velocity increased by 35%, and the repair effect of nerve fibers was more significant.

[0124] Sensory function recovery rate: After treatment, sensory function recovered by 60%, and the patient's ability to respond to external stimuli was significantly improved.

[0125] Motor function recovery rate: After treatment, motor function recovered by 65%, and the patient's muscle control and coordination abilities were significantly improved.

[0126] Improvement in autonomic nervous function: After treatment, the patient's autonomic nervous function was significantly improved and the overall condition improved significantly.

[0127] Overall efficacy evaluation: 90% of the patients showed significant improvement after treatment, and the overall efficacy was significantly better than that of Example 1 and Example 2.

[0128] Example 4 Drug Efficacy Test

[0129] Neurological deficit score: The average score before treatment was 13.5±1.8, which dropped to 7.0±1.2 after treatment. The neurological repair effect was very significant.

[0130] Improvement rate of nerve conduction velocity: After treatment, the nerve conduction velocity increased by 45%, and the repair effect of nerve fibers reached a high level.

[0131] Sensory function recovery rate: After treatment, sensory function recovered by 75%, and the patient's ability to respond to external stimuli was greatly improved.

[0132] Motor function recovery rate: After treatment, motor function recovered by 80%, and the patient's muscle control and coordination abilities were significantly improved.

[0133] Improvement in autonomic nervous function: After treatment, the patient's autonomic nervous function was significantly improved, and the overall condition was close to normal levels.

[0134] Overall efficacy evaluation: 95% of patients said that they had significant improvement after treatment, and the overall efficacy was very significant

[0135] Example 5 Drug Efficacy Test

[0136] Neurological deficit score: The average score before treatment was 13.0±1.5, which dropped to 5.5±1.0 after treatment, and the neurological repair effect reached the best level.

[0137] Improvement rate of nerve conduction velocity: After treatment, the nerve conduction velocity increased by 55%, and the repair effect of nerve fibers was extremely significant.

[0138] Sensory function recovery rate: After treatment, sensory function recovered by 90%, and the patient's ability to respond to external stimuli basically returned to normal.

[0139] Motor function recovery rate: After treatment, motor function recovered by 95%, and the patient's muscle control and coordination abilities were greatly improved.

[0140] Improvement of autonomic nervous function: After treatment, the patient's autonomic nervous function was fully restored and the overall condition returned to normal levels.

[0141] Overall efficacy evaluation: 100% of the patients indicated significant improvement after treatment. The overall efficacy is extremely significant and is an ideal solution for treating nerve damage. Example 1: Data parameters of nerve damage repair drugs in Table 1 are as follows:

[0142]

[0143] Example 2 Nerve injury repair drug data parameter table 1 is as follows:

[0144]

[0145] Example 3 Nerve injury repair drug data parameter table 1 is as follows:

[0146]

[0147] Example 4 Nerve injury repair drug data parameter table 1 is as follows:

[0148]

[0149] Example 5 Nerve damage repair drug data parameter table 1 is as follows:

[0150]

[0151]

[0152] The embodiments of the present invention disclose preferred embodiments, but are not limited thereto. A person skilled in the art can easily understand the spirit of the present invention based on the above embodiments and make different extensions and changes. However, as long as they do not deviate from the spirit of the present invention, they are all within the protection scope of the present invention.

Claims

1. A nerve damage repair drug based on a traditional Chinese medicine compound, characterized in that: Includes the following parts by weight: Gentiana macrophylla 6-15 grams, Stephania tetrandra 6-12 grams, Clematis 6-15 grams, Morus twig 10-30 grams, Caulis Piperis 6-15 grams, Caulis Sinomenii 6-15 grams, Angelica 9-15 grams, Ligusticum chuanxiong 6-12 grams, Safflower 3-10 grams, Cinnamon twig 6-15 grams, Gastrodia elata 6-15 grams, Uncaria rhynchophylla 9-15 grams, Cassia bark 10-30 grams, Gardenia jasminoides 6-12 grams, Scutellaria baicalensis 6-15 grams, Achyranthes bidentata 9-15 grams, Viscum album 9-15 grams, Polygonum multiflorum 9-15 grams, Poria 9-15 grams, Leonurus japonicus 9-30 grams.

2. The nerve damage repair drug based on a traditional Chinese medicine compound as claimed in claim 1, characterized in that: 6 grams of Qinjiao, 6 grams of Fangji, 6 grams of Clematis, 10 grams of Morus, 6 grams of Piper mesenteriae, 6 grams of Sinomenium, 9 grams of Angelica sinensis, 6 grams of Chuanxiong, 3 grams of Carthamus tinctorius, 6 grams of Cassia twig, 6 grams of Gastrodia elata, 9 grams of Uncaria rhynchophylla, 10 grams of Semen Cassiae, 6 grams of Gardenia jasminoides, 6 grams of Scutellaria baicalensis, 9 grams of Achyranthes bidentata, 9 grams of Viscum album, 9 grams of Polygonum multiflorum, 9 grams of Poria, and 9 grams of Leonurus japonicus.

3. The nerve damage repair medicine based on a traditional Chinese medicine compound as claimed in claim 1, characterized in that: 8 grams of Qinjiao, 8 grams of Fangji, 8 grams of Clematis, 15 grams of Morus, 8 grams of Piper mesenteriae, 8 grams of Sinomenium, 12 grams of Angelica sinensis, 8 grams of Chuanxiong, 5 grams of Safflower, 8 grams of Cassia twig, 8 grams of Gastrodia elata, 12 grams of Uncaria rhynchophylla, 15 grams of Semen Cassiae, 8 grams of Gardenia, 8 grams of Scutellaria baicalensis, 12 grams of Achyranthes bidentata, 12 grams of Viscum album, 12 grams of Polygonum multiflorum, 12 grams of Poria, and 12 grams of Leonurus japonicus.

4. The nerve damage repair medicine based on a traditional Chinese medicine compound according to claim 1, characterized in that: 10 grams of Qinjiao, 10 grams of Fangji, 10 grams of Clematis, 20 grams of Morus twig, 10 grams of Piper mesenteriae, 10 grams of Sinomenium strychnifolia, 15 grams of Angelica sinensis, 10 grams of Chuanxiong, 7 grams of Safflower, 10 grams of Cassia twig, 10 grams of Gastrodia elata, 15 grams of Uncaria rhynchophylla, 20 grams of Semen Cassiae, 10 grams of Gardenia jasminoides, 10 grams of Scutellaria baicalensis, 15 grams of Achyranthes bidentata, 15 grams of Viscum album, 15 grams of Polygonum multiflorum, 15 grams of Poria cocos, and 15 grams of Leonurus japonicus.

5. The nerve damage repair medicine based on a traditional Chinese medicine compound as claimed in claim 1, characterized in that: 12 grams of Qinjiao, 12 grams of Fangji, 12 grams of Clematis, 25 grams of Morus, 12 grams of Piper mesenteriae, 12 grams of Sinomenium, 12 grams of Angelica sinensis, 12 grams of Chuanxiong, 9 grams of Safflower, 12 grams of Cassia twig, 12 grams of Gastrodia elata, 20 grams of Uncaria rhynchophylla, 25 grams of Semen Cassiae, 12 grams of Gardenia, 12 grams of Scutellaria baicalensis, 20 grams of Achyranthes bidentata, 20 grams of Viscum album, 20 grams of Polygonum multiflorum, 20 grams of Poria cocos, and 20 grams of Leonurus japonicus.

6. The nerve damage repair drug based on a traditional Chinese medicine compound according to claim 1, characterized in that: 15 grams of Qinjiao, 15 grams of Fangji, 15 grams of Clematis, 30 grams of Morus, 15 grams of Piper mesenteriae, 15 grams of Qingfengteng, 20 grams of Angelica sinensis, 15 grams of Chuanxiong, 10 grams of Safflower, 15 grams of Cassia twig, 15 grams of Gastrodia elata, 25 grams of Uncaria rhynchophylla, 30 grams of Semen Cassiae, 15 grams of Gardenia jasminoides, 15 grams of Scutellaria baicalensis, 25 grams of Achyranthes bidentata, 25 grams of Viscum album, 25 grams of Polygonum multiflorum, 25 grams of Poria cocos, and 30 grams of Leonurus japonicus.

7. A method for preparing a nerve damage repair drug based on a traditional Chinese medicine compound according to any one of claims 1 to 6, characterized in that: The following steps are involved: S1. Drug extraction and concentration Mix the medicinal materials of Gentiana macrophylla, Stephania tetrandra, Clematis chinensis, Morus alba, Caulis Piperis ternata, Caulis Sinomenii, Angelica sinensis, Rhizoma Chuanxiong, Safflower, Cinnamon twig, Gastrodia elata, Uncaria rhynchophylla, Semen Cassiae, Gardenia jasminoides, Scutellaria baicalensis, Achyranthes bidentata, Morus alba, Caulis Polygoni Multiflori, Poria cocos, and Leonurus japonicus in a certain proportion, wash and remove impurities, put the washed medicinal materials into a decoction container, add an appropriate amount of water, and decoct, control the heat and time during the decoction process to ensure that the effective ingredients in the medicinal materials are fully dissolved, filter the decoction liquid, remove the residue, obtain a clarified medicinal liquid, evaporate and concentrate the medicinal liquid to obtain a thick paste-like medicinal liquid, and prepare for subsequent granulation; S2. Preparation of preparation granules The concentrated drug solution is added to an appropriate amount of dry excipients, mixed evenly, the mixed drug solution is granulated by a granulator to obtain particles of uniform size, and the obtained particles are dried to reduce the water content of the particles and improve the stability of the preparation; S3, edible nano vacuum film coating Selecting edible and soluble nanomaterials as vacuum membranes, placing the dried particles in a nano vacuum membrane coating device for nano vacuum membrane coating treatment; S4. Granule packaging and storage The particles coated with the nano vacuum film are screened and inspected to ensure the quality and stability of the particles. The screened particles are packaged and sealed in plastic bags or bottles. The packaged powder is stored in a cool and dry place, avoiding direct sunlight and high temperature environment.

8. The preparation method according to claim 7, characterized in that: The dry excipient in S2 is one of sucrose, starch, lactose and cellulose derivatives.

9. The preparation method according to claim 7, characterized in that: The nano vacuum membrane in S3 is one of modified starch nano membrane, protein nano membrane, sodium alginate nano membrane and chitosan nano membrane.

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