Anti-oxidation and anti-aging composition as well as preparation method and application thereof

Abstract

The invention provides an anti-oxidation and anti-aging composition as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicines. The composition is prepared from the following raw material components in parts by weight: 25 to 40 parts of radix astragali seu hedysari, 5 to 10 parts of radix angelicae sinensis, 18 to 25 parts of fructus mori, 8 to 15 parts of fructus crataegi, 8 to 15 parts of fructus hordei germinatus and 2 to 5 parts of pericarpium citri reticulatae. Wherein the weight ratio of astragalus membranaceus to angelica sinensis is 5: 1, and the weight ratio of mulberry to hawthorn to malt is (18-25): (8-15): (8-15). All the raw material components in the composition are matched for use, so that the composition has remarkable anti-oxidation and anti-aging effects.

Description

Technical Field

[0001] The present invention belongs to the technical field of traditional Chinese medicine, and specifically relates to an anti-oxidation and anti-aging composition and a preparation method and application thereof. Background Art

[0002] Aging refers to the process in which the functions of various organs of the human body gradually decline. Physical aging is mainly manifested in the skin, cardiovascular system, nervous system, digestive system, etc. Among them, the aging of the nervous system can lead to slow reactions, such as a series of changes in the nervous system such as decreased learning, memory, judgment, and coordination ability, and the sensitivity of temperature regulation will also decrease. Some elderly people are also prone to Alzheimer's disease. The human body contains a variety of endogenous antioxidant enzymes and low-molecular antioxidants, which can capture free radicals that harm the human body, so that the production and elimination of free radicals in the body are in a dynamic balance, so that the body is not harmed. With the increase of age, the activity of antioxidant enzymes such as superoxide dismutase (SOD) in the human body decreases, and the ability to remove oxygen free radicals in the body decreases. Excessive concentrations of oxygen free radicals act on nucleic acids, proteins, cell membranes, enzymes, etc., causing irreversible damage, thereby leading to physiological disorders and even pathological changes in the body.

[0003] Chinese invention patent application CN112273649A discloses an antioxidant and anti-aging composition, preparation method and application, the composition includes the following components: American ginseng, brown algae peptide, black fruit glandular costa berry, β-nicotinamide mononucleotide, wolfberry polysaccharide, sea buckthorn polysaccharide, mulberry polysaccharide and roxburghii polysaccharide. However, it contains relatively expensive raw materials such as brown algae peptide and β-nicotinamide mononucleotide, and it contains ingredients such as wolfberry polysaccharide, sea buckthorn polysaccharide, mulberry polysaccharide and roxburghii polysaccharide, so the application of the composition is limited for people with sugar intolerance.

[0004] Chinese invention patent application CN117918515A discloses an anti-fatigue nutritional preparation, comprising the following ingredients: 25-35 parts by weight of astragalus, 10-20 parts by weight of codonopsis, 5-10 parts by weight of angelica, 5-15 parts by weight of dried orange peel, 8-15 parts by weight of jujube, 8-15 parts by weight of wolfberry, 8-15 parts by weight of hawthorn, 8-15 parts by weight of lily, 10-20 parts by weight of yam, 2-8 parts by weight of chicken gizzard lining, and 2-8 parts by weight of malt. The above application has many components, and it does not disclose the effects of anti-aging and anti-oxidation.

[0005] Although there are many compositions with antioxidant and anti-aging effects at present, there is a lack of a pure Chinese medicine preparation composition with antioxidant and anti-aging effects that has low cost, few components, is applicable to a wide range of people, and has good effects. Summary of the invention

[0006] In view of the problems existing in the prior art, the present invention provides an antioxidant and anti-aging composition and a preparation method and application thereof. Through the reasonable combination of components, the composition provided by the present invention has the characteristics of good antioxidant and anti-aging effects, low cost, few components, and wide applicability.

[0007] To achieve the above purpose, the technical solution adopted by the present invention is as follows: The first object of the present invention is to provide an antioxidant and anti-aging composition. The raw material components are, by weight, 25-40 parts of astragalus, 5-10 parts of angelica, 18-25 parts of mulberry, 8-15 parts of hawthorn, 8-15 parts of malt, and 2-5 parts of tangerine peel, wherein the weight ratio of astragalus to angelica is 5:1, and the weight ratio of mulberry, hawthorn and malt is 18-25:8-15:8-15.

[0008] Preferably, the raw material components are as follows, by weight: 28-35 parts of astragalus, 6-8 parts of angelica, 18-22 parts of mulberry, 8-12 parts of hawthorn, 8-12 parts of malt, and 2-4 parts of tangerine peel.

[0009] Further preferably, the raw material components are, by weight: 30 parts of astragalus, 6 parts of angelica, 20 parts of mulberry, 10 parts of hawthorn, 10 parts of malt, and 2 parts of tangerine peel.

[0010] Preferably, the composition further comprises a pharmaceutically acceptable excipient.

[0011] Further preferably, the auxiliary material is selected from any one or more of dextrin, maltodextrin, soluble starch and lactose.

[0012] The second object of the present invention relates to a method for preparing the above-mentioned composition, comprising the following steps: (1) Weigh the raw materials, add water and boil repeatedly, filter, and combine the filtrate; (2) Concentrate the combined filtrate to an extract, add auxiliary materials, and dry to obtain the extract.

[0013] Preferably, in step (1), the number of repeated water addition and decoction is 1-3 times, the amount of water added for a single decoction is 6-10 times the amount of raw materials, and the single decoction time is 1-2 hours.

[0014] Preferably, in step (2), the extract is a traditional Chinese medicine extract containing 2 g / mL of crude drug.

[0015] The third object of the present invention relates to the use of the above composition in the preparation of antioxidant and anti-aging drugs.

[0016] Preferably, the dosage form of the drug is not limited to pills, capsules, granules, oral liquids, powders, tablets, lozenges, pastes and other dosage forms, and suitable drug carriers in the art can be selected for different dosage forms.

[0017] Astragalus, which comes from the "Shennong Bencao Jing", has been praised since ancient times as a good medicine for replenishing qi and raising yang, consolidating the exterior and stopping sweating, promoting diuresis and reducing swelling, promoting fluid and nourishing blood, relieving stagnation and relieving arthritis, expelling toxins and draining pus, and healing sores and promoting tissue regeneration. In the anti-aging treatment of middle-aged and elderly people, astragalus plays the role of the main medicine with its excellent qi-replenishing effect. It can not only significantly enhance the body's immune function and improve disease resistance, but also promote the biochemical transformation of qi and blood, improve the body's anti-fatigue ability, provide stable energy support for the brain, and is conducive to the improvement of learning and memory ability, thereby delaying the body's aging process.

[0018] Angelica sinensis, a holy medicine for nourishing blood and regulating menstruation, comes from the "Shennong Bencao Jing". It is matched with Astragalus membranaceus in a ratio of one to five. It comes from the Angelica sinensis Blood-Replenishing Soup created by Li Dongyuan in the Jin and Yuan Dynasties. The two complement each other and play the effect of replenishing qi, nourishing blood and activating blood circulation. Angelica sinensis, with its functions of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relieving constipation, is used together with Astragalus membranaceus to greatly enhance the power of nourishing blood, and effectively improves the symptoms of pale complexion, dizziness and other deficiency caused by insufficient qi and blood in middle-aged and elderly people. At the same time, the blood-activating properties of Angelica sinensis help to unclog blood vessels and promote blood circulation, including microcirculation in the brain, and provide the brain with sufficient oxygen and nutrients. In traditional Chinese medicine theory, blood deficiency may lead to memory loss. Angelica sinensis improves the brain's nutrient supply by nourishing blood and activating blood circulation, thereby indirectly promoting the recovery and improvement of brain function, including learning and memory ability.

[0019] Mulberries are a good product for nourishing yin and blood, promoting fluid production and moistening dryness, nourishing the liver and improving eyesight. They serve as the assistant medicine in this prescription, assisting astragalus and angelica to further consolidate the foundation of nourishing blood and yin. Mulberries are effective in nourishing the liver and improving eyesight, and are particularly suitable for treating vision loss, dizziness, tinnitus and other symptoms caused by liver and kidney yin deficiency in middle-aged and elderly people.

[0020] Hawthorn is an expert at digesting food, removing accumulation, promoting qi and relieving blood stasis, and lowering blood lipids. Its addition not only strengthens the spleen-strengthening and food-promoting function of this prescription, and promotes digestion and absorption in middle-aged and elderly people, but also adds new strength to the prevention of cardiovascular and cerebrovascular diseases and delaying aging with its unique lipid-lowering and blood vessel softening effects.

[0021] Barley malt, or malt, is a good medicine for digestion, stomach function, lactation, and bloating, and relieves liver and depression. It complements hawthorn and optimizes the spleen and stomach function of the elderly and promotes digestion and absorption. Malt is particularly good at regulating emotions and relieving physical discomfort caused by emotional fluctuations in the elderly, reflecting the wisdom of Chinese medicine emotional therapy. In Chinese medicine theory, the liver is responsible for regulating and dispersing emotions, which is closely related to emotional activities. Malt can relieve liver and depression, improve emotional state, and help the brain stay clear and focused, thereby indirectly improving learning and memory efficiency.

[0022] Tangerine peel is a good product for regulating qi and strengthening the spleen, drying dampness and resolving phlegm, and promoting qi and relieving pain. As an adjuvant in this prescription, it can not only help digestion, but also dry dampness and resolve phlegm, and improve symptoms such as cough, phlegm, dizziness, and memory loss caused by phlegm and dampness in the middle-aged and elderly. Tangerine peel improves the internal environment by drying dampness and resolving phlegm, creating a healthier working condition for the brain, which is indirectly beneficial to the improvement of learning and memory ability of the elderly.

[0023] In summary, this modified prescription is based on Danggui Buxue Decoction, with Astragalus and Danggui as the main ingredients, replenishing qi and nourishing blood; mulberry as the minister, enhancing blood and yin nourishing; hawthorn and malt as the auxiliary ingredients, strengthening the spleen and digestion, soothing the liver and relieving depression; tangerine peel as the envoy, regulating qi and resolving phlegm, and promoting qi and relieving pain. The whole prescription has the effects of replenishing qi and nourishing blood, nourishing yin and moistening dryness, digesting food and resolving accumulation, promoting qi and dispersing blood stasis, soothing the liver and relieving depression, and lowering blood lipids. It aims to enhance the physical strength and immunity of middle-aged and elderly people, improve memory and learning ability, and is the preferred prescription for anti-aging, prevention and treatment, and anti-oxidation in middle-aged and elderly people.

[0024] Compared with the prior art, the present invention has the following beneficial effects: the composition provided by the present invention can improve the learning and memory functions of aging mice, and can also reduce the levels of MDA and SOD in brain tissue, alleviate the level of oxidative stress in brain tissue, reduce the generation of β-galactosidase, and slow down the degree of brain tissue aging, with significant effects. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 : Partial movement trajectory diagram of mice in each group undergoing Morris water maze test; Figure 2 : Results of the positioning navigation experiment of mice in each group; Figure 3 : Results of the space exploration experiment of mice in each group on the last day; Figure 4 : The results of the number of times each group of mice crossed the platform; Figure 5 :Results of MDA level detection in mouse brain tissue; Figure 6 :The results of SOD level detection in mouse brain tissue; Figure 7 : Results of ROS fluorescence detection in mouse brain slices (Note: the number in the lower right corner of each picture is 1.25 mm); Figure 8 :β-galactosidase staining results of mouse brain sections. DETAILED DESCRIPTION

[0026] The following non-limiting examples can enable those skilled in the art to more fully understand the present invention, but do not limit the present invention in any way. The following content is merely an exemplary description of the scope of the present invention, and those skilled in the art can make various changes and modifications to the present invention based on the disclosed content, which should also fall within the scope of the present invention.

[0027] When the embodiments give numerical ranges, it should be understood that, unless otherwise specified in the present invention, both endpoints of each numerical range and any numerical value between the two endpoints can be selected. Unless otherwise defined, all technical and scientific terms used in the present invention have the same meanings as those generally understood by those of ordinary skill in the art to which the present invention belongs.

[0028] The present invention is further described below by way of specific examples. Unless otherwise specified, the various chemical reagents and raw materials used in the examples of the present invention are obtained through conventional commercial channels.

[0029] Formula 1: An antioxidant and anti-aging composition, the raw material components by weight are: 30 parts of astragalus, 6 parts of angelica, 20 parts of mulberry, 10 parts of hawthorn, 10 parts of malt, and 2 parts of tangerine peel. The preparation method is: take 8 times the weight of the raw material pure water and boil it at 600W high fire, then change to 200W slow fire to decoct for 2h, filter and collect the liquid medicine, decoct the residue again with 8 times the volume of pure water for 1h, filter and collect the liquid medicine, and concentrate the combined liquid medicine with a rotary evaporator to a Chinese medicine extract containing 2g / mL of raw medicine.

[0030] Experimental Example 1: Antioxidant and anti-aging in vitro experiments 1. Animal modeling and drug administration: 1) 8-week-old male C57BL6 / J mice (20-25g) were selected and randomly divided into a normal group (Control group), a model group (D-gal group), a positive drug group (D-gal+DNP), a low-dose group of formula 1 (D-gal+DL) and a high-dose group of formula 1 (D-gal+DH group) after one week of adaptive feeding. Except for the normal group, which was injected with an equal volume of injection water every day, the other groups were intraperitoneally injected with D-galactose (D-gal) for 10 weeks. Starting from the third week, the D-gal+DNP, D-gal+DL and D-gal+DH groups were gavaged with corresponding doses of drugs every day for 8 weeks. Behavioral tests were performed in the 11th week, and the experimental animals were killed after the end.

[0031] 2) Dosage: D-galactose: 120 mg / kg; low dose concentration of formulation 1: 6 mg / kg / day; high dose of formulation 1: 12 mg / kg / day; the positive drug is donepezil (DNP), with a dose of 3 mg / kg / day.

[0032] 2. Morris water maze test: The Morris water maze experiment includes three parts: adaptive training during the platform visible period, positioning navigation during the platform invisible period, and space exploration. The water temperature is always controlled at 22 ± 2 ℃ during the experiment. The specific experimental steps are as follows: 1) Build a water maze facility. The first day of the experiment is the platform visibility period experiment. Mice are trained to find a safe platform. Mice are kept in the behavioral laboratory 10 hours in advance for environmental adaptation. The swimming pool is divided into four quadrants. The platform is located in one of the quadrants, 1 cm above the water surface. The pool water is kept transparent, and black markers are placed on the platform to ensure that the mice can see the platform in the water. First, place the mouse on the safe platform for 20 seconds, then gently hold the mouse by hand and place the mouse in the water in four quadrants in turn for four experiments. When placing the mouse, let the mouse's head face the pool wall, enter the water gently and slowly, and let the animal's head enter the water first. Let the mouse freely explore in the water to find a safe platform for 1 minute. If it reaches the platform within 1 minute and stops for 10 seconds, it is considered to have successfully found the platform. If the platform is not found for more than 1 minute, it is manually guided to the safe platform and the mouse is allowed to stay on the platform for 15 seconds or more. Each mouse is tested 4 times. After the experiment is completed, the mouse is immediately fished out of the swimming pool, dried with a towel, and placed in a mouse cage next to the heater. Subsequent experiments were performed after screening out mice that swam too slowly due to injuries to their motor organs, stayed still in the water for a long time, and swam too fast.

[0033] 2) On the second day of the experiment, the navigation experiment was started. The safety platform was still in the same quadrant as on the first day. At this stage, non-toxic dye was poured into the water and mixed to make the pool completely turbid. The platform was placed 0.5 cm below the water surface to ensure that the mice could not see the safety platform when they were in the water. The mice were gently placed in the water facing the pool wall. The mice were allowed to determine their position in the water with the help of the marks on the pool wall. They were allowed to freely explore and search for the safety platform for 1 minute. If they climbed onto the safety platform within 1 minute and stayed on the platform for 10 seconds, they were considered to have successfully climbed onto the platform. If the platform was not found within 1 minute, they were manually guided to the safety platform and allowed to stay on the platform for 15 seconds before continuing the next experiment. The navigation experiment was carried out for 4 consecutive days, with the mice entering the water in four different quadrants every day. The time it took the mice to find and climb onto the platform was called the incubation period. If the mice did not climb onto the safety platform within 1 minute, the incubation period was recorded as 60 seconds. The incubation period of each mouse was recorded in the experiment and the video data of the whole process was retained.

[0034] 3) On the 7th day of the experiment, the spatial exploration experiment was started. The safety platform in the water maze was removed, and the swimming pool was turbid with non-toxic dye. The mice were placed in the water at the point farthest from the original safety platform. The mice were gently placed in the water facing the pool wall. The mice were allowed to determine their position in the water with the help of the marks on the pool wall and explore freely for 1 minute. The time the mice stayed in the quadrant where the original platform existed (the target quadrant) and the time they crossed the platform were recorded within 60 seconds.

[0035] Part of the movement trajectory of each group of mice in the Morris water maze test is shown below: Figure 1 The movement trajectory and speed of mice in the water maze were recorded. If mice floated in the water and did not swim in 3 or more of the 4 experiments, they were directly eliminated and did not participate in the subsequent water maze experiments.

[0036] Figure 2 The experimental results showed that in the positioning navigation experiment, as the experimental days increased, the incubation period of all mice gradually shortened, but the incubation period of the D-gal group was still significantly longer than that of other experimental groups, and the incubation period of the D-gal+DH group was significantly lower than that of the D-gal group (P<0.01).

[0037] like Figure 3 As shown, in the last day of the spatial exploration experiment, the time that the D-gal group mice stayed in the platform quadrant was significantly reduced, and the time that the D-gal+DH group and the D-gal group stayed in the platform quadrant was significantly increased (P<0.05).

[0038] like Figure 4 As shown, the number of times the mice in the D-gal group crossed the platform was significantly reduced, and except for the D-gal+DL group, the other groups showed a significant increase in the number of times they crossed the platform compared with the D-gal group.

[0039] 3. Detection of MDA levels in mouse brain tissue: Steps for determining the level of MDA in brain tissue: ① Sampling: After the mouse is anesthetized and killed, the brain tissue is quickly removed. ② Homogenization and extraction: The obtained brain tissue sample is homogenized with MDA extract, centrifuged at 4°C, and the supernatant is taken as the analysis sample. ③ MDA determination: Take a certain amount of supernatant, add an equal volume of thiobarbituric acid (TBA) solution, and heat in a boiling water bath for 60 minutes to react MDA with TBA to generate reddish-brown trimethoprim (3,5,5-trimethyloxazole-2,4-dione). ④ Determination of absorbance: Cool the solution after the reaction to room temperature and use a spectrophotometer to measure the absorbance at a wavelength of 532nm. ⑤ Statistical analysis: Calculate the concentration and content of MDA in the sample, and use GraphPad Prism to make a graph.

[0040] like Figure 5 As shown, the MDA level of mice in the D-gal group was increased, and the MDA levels of mice in the other groups except the D-gal+DL group were significantly lower than those in the D-gal group.

[0041] 4. Detection of SOD levels in mouse brain tissue: Steps for determining the level of SOD in brain tissue: ① Sampling: After the mouse is anesthetized and killed, the brain tissue is quickly removed. ② Homogenization and extraction: The obtained brain tissue sample is homogenized with SOD extract, centrifuged at 4℃ 12000×g, and the supernatant is taken as the analysis sample. Weigh an appropriate amount of brain tissue sample and place it in a pre-cooled mortar. ③ SOD activity determination: Divide into a test group and a control group. Add an appropriate amount of pure water and SOD working solution to each group. Add an appropriate amount of homogenate to the test group, and add an equal amount of SOD extract to the control group as a blank control. ④ Determine absorbance: After adding the sample, incubate at 37℃ for 30min, and measure the absorbance value at a wavelength of 450nm. ⑤ Statistical analysis: Calculate SOD activity according to the formula: Enzyme activity = [(ODC-ODS) / (ODC)×V / Vs] / W, where V is the total volume of the sample extract (mL), Vs is the volume of the sample extract taken during the determination (mL), and W is the sample weight (g). The calculated SOD activity values ​​were subjected to statistical analysis.

[0042] like Figure 6 As shown, the SOD activity of mice in the D-gal group was reduced, while the SOD activity of the other groups was significantly increased compared with that of the D-gal group.

[0043] 5. ROS fluorescence in mouse brain slices: Specific steps for ROS fluorescence in brain tissue: ① Sampling: Use pre-cooled PBS to perfuse the heart of anesthetized mice, and immediately remove the whole brain of the mouse. ② Fixation: The whole brain of the mouse is placed in paraformaldehyde for pre-fixation. ③ Slicing: Use OTC for embedding, and use a freezing microtome to slice into 20μm thick brain slices. ④ Fluorescent probe: Add an appropriate volume of ROS staining solution to ensure that the tissue is fully covered, and incubate in a wet box at 37°C for 30 minutes. ⑤ Observation and analysis: Observe the stained brain tissue slices under a fluorescence microscope.

[0044] like Figure 7 As shown, the ROS level of mice in the D-gal group was increased, and the ROS levels of the other groups except the D-gal+DL group were significantly lower than those of the D-gal group.

[0045] 6. β-galactosidase staining of mouse brain sections: Specific steps for brain tissue β-galactosidase staining: ① Sampling: Use pre-cooled PBS to perform cardiac perfusion on anesthetized mice, and immediately remove the whole brain of the mouse. ② Fixation: The whole brain of the mouse is placed in paraformaldehyde for pre-fixation. ③ Sectioning: Use OTC for embedding, and use a freezing microtome to slice into 20μm thick brain slices. ④ Staining: Add an appropriate volume of β-galactosidase staining fixative to ensure that the tissue is fully covered, and fix at room temperature for at least 15 minutes. Soak and wash the tissue 3 times with PBS, each time for no less than 5 minutes. Aspirate PBS and add an appropriate amount of β-galactosidase staining working solution (X-gal). Incubate overnight at 37°C, and use plastic wrap to seal to prevent evaporation. ⑤ Observation and analysis: Observe the stained brain tissue sections under a microscope to distinguish between cells stained blue (cells expressing β-galactosidase) and unstained cells.

[0046] like Figure 8 As shown, the β-galactosidase staining degree of mice in the D-gal group was darker, and the β-galactosidase staining degree of mice in the other groups except the D-gal+DL group was lighter than that of the D-gal group.

[0047] Example 1 An anti-oxidation and anti-aging composition comprises the following raw material components by weight: 25 parts of astragalus, 5 parts of angelica, 18 parts of mulberry, 8 parts of hawthorn, 8 parts of malt and 2 parts of tangerine peel.

[0048] Example 2 An anti-oxidation and anti-aging composition comprises the following raw material components by weight: 40 parts of astragalus, 8 parts of angelica, 25 parts of mulberry, 15 parts of hawthorn, 15 parts of malt and 5 parts of tangerine peel.

[0049] Embodiment 1 and embodiment 2 are obtained by the following preparation method: Take 8 times the weight of raw material pure water and boil it at 600W high heat, then change to 200W low heat and simmer for 2 hours, filter and collect the medicinal liquid, boil the residue again with 8 times the volume of pure water for 1 hour, filter and collect the medicinal liquid, and concentrate the combined medicinal liquid with a rotary evaporator to a Chinese medicine extract containing 2 g / mL of raw medicine.

[0050] Finally, it should be noted that the above content is only used to illustrate the technical solution of the present invention, rather than to limit the scope of protection of the present invention. Simple modifications or equivalent substitutions of the technical solution of the present invention by ordinary technicians in this field do not deviate from the essence and scope of the technical solution of the present invention.

Claims

1. An antioxidant and anti-aging composition, characterized in that: The raw material components are as follows: 25-40 parts of astragalus, 5-10 parts of angelica, 18-25 parts of mulberry, 8-15 parts of hawthorn, 8-15 parts of malt, 2-5 parts of tangerine peel, The weight ratio of astragalus to angelica is 5:1, and the weight ratio of mulberry, hawthorn and malt is 18-25:8-15:8-15.

2. The composition according to claim 1, characterized in that Calculated by weight, the raw material components are: 28-35 parts of astragalus, 6-8 parts of angelica, 18-22 parts of mulberry, 8-12 parts of hawthorn, 8-12 parts of malt, and 2-4 parts of tangerine peel.

3. The composition according to claim 1, characterized in that In terms of weight, the raw material components are: 30 parts of astragalus, 6 parts of angelica, 20 parts of mulberry, 10 parts of hawthorn, 10 parts of malt, and 2 parts of tangerine peel.

4. The composition according to any one of claims 1 to 3, characterized in that The composition further includes a pharmaceutically acceptable excipient.

5. The composition according to claim 4, characterized in that The auxiliary material is selected from any one or more of dextrin, maltodextrin, soluble starch and lactose.

6. A method for preparing the composition according to any one of claims 1 to 5, characterized in that: The steps include: (1) Weigh the raw materials, add water and boil repeatedly, filter, and combine the filtrate; (2) Concentrate the combined filtrate to obtain an extract, add auxiliary materials, and dry to obtain the extract.

7. The preparation method according to claim 6, characterized in that: In step (1), the number of repeated water addition and decoction is 1-3 times, the amount of water added for a single decoction is 6-10 times the amount of the raw material, and the single decoction time is 1-2 hours.

8. The preparation method according to claim 6, characterized in that: In step (2), the extract is a traditional Chinese medicine extract containing 2 g / mL of crude drug.

9. Use of the composition according to any one of claims 1 to 5 or the composition prepared by the preparation method according to any one of claims 6 to 8 in the preparation of antioxidant and anti-aging drugs.

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