Traditional Chinese medicine composition for treating rheumatism, gout, hyperuricemia and sciatica and preparation method thereof

Abstract

The invention provides a traditional Chinese medicine composition for treating rheumatism, gout, hyperuricemia and sciatica, and belongs to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition comprises calculus bovis factitius, notopterygium root, turmeric, salvia miltiorrhiza, myrrh, sculellaria barbata, radix clematidis, radix aconiti preparata, radix paeoniae alba, radix paeoniae rubra, rhizoma sparganii, curcuma zedoary, gecko, frankincense, herba epimedii and ginger. Through the synergistic effect of the medicines, the effects of promoting blood circulation to remove blood stasis, dispelling wind, eliminating dampness, dispelling wind-cold damp evil, activating collaterals and relieving pain are achieved. The traditional Chinese medicine composition has a good treatment effect on rheumatoid arthritis, gout, hypeluricemia and sciatica, is rich in medicine source, low in price, simple in preparation method and easy to operate, has the total effective rate of 92.01%, and has no side effect.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating rheumatism, gout, hyperuricemia and sciatica and a preparation method thereof. Background Art

[0002] Rheumatoid arthritis is a common acute or chronic connective tissue inflammation and one of the main manifestations of rheumatic fever. It usually presents with acute fever and joint pain. Clinically, it is characterized by migratory soreness, heaviness, and pain in the joints and muscles. It is an allergic disease that can recur and affect the heart. Rheumatoid arthritis broadly includes rheumatoid arthritis. Rheumatoid arthritis is a chronic, systemic disease with unknown etiology, characterized by polyarticular, symmetrical, invasive joint inflammation of the small joints of the hands and feet, often accompanied by extra-articular organ involvement and positive serum rheumatoid factor, which can lead to joint deformities and loss of function.

[0003] Gout is a metabolic disease caused by abnormal purine metabolism, which leads to increased uric acid synthesis. Acute gout attacks are characterized by severe pain, swelling, erythema, stiffness, and fever in the affected joints, and the symptoms occur suddenly. Hyperuricemia is mainly caused by excessive uric acid production and / or reduced uric acid excretion in the body. Uric acid is the end product of purine metabolism. When high-purine foods such as animal offal, seafood, and broth are ingested, the body will produce a large amount of uric acid after breaking down these purines. In addition, the body's own cell metabolism also produces purines. Some diseases (such as malignant tumors) can accelerate cell proliferation or increase cell destruction, leading to excessive purine production, which in turn leads to excessive uric acid production. Some people have decreased uric acid excretion ability due to impaired renal function, while others are born with weaker uric acid excretion functions. Some people also take certain drugs (such as thiazide diuretics) that affect uric acid excretion.

[0004] Sciatica is a syndrome characterized by pain in the sciatic nerve pathway and distribution area. It is divided into primary and secondary sciatica according to different causes. Primary sciatica is sciatica, which is rare in clinical practice and is often related to the source of infection in the body. Secondary sciatica refers to pain secondary to the stimulation, compression and damage to the sciatic nerve caused by lesions in the local and surrounding structures of the sciatic nerve. The most common cause is lumbar disc herniation, and spinal stenosis, tumors, tuberculosis, compression of the pregnant uterus, arachnoiditis, etc. can also cause it.

[0005] Although there are many drugs for rheumatoid arthritis, gout, hyperuricemia and sciatica at present, most of them are short-lived in pain relief, and the effects are slow and unstable. The drugs used in the existing treatment methods include non-steroidal anti-inflammatory drugs, salicylic acid preparations, indomethacin, propionic acid derivatives, and immunosuppressants such as azathioprine, cyclophosphamide, and methotrexate. It has the advantages of fast onset, good analgesia, and uric acid-lowering effects, but has large side effects, and long-term use has damage to liver and kidney function. However, some existing Chinese medicines have unstable efficacy and are prone to recurrence. Therefore, it is urgent to provide a safe, effective and side-free Chinese medicine composition for the treatment of rheumatism, gout, hyperuricemia and / or sciatica. Summary of the invention

[0006] In order to solve the problems existing in the prior art, the purpose of the present invention is to provide a traditional Chinese medicine composition for treating rheumatism, gout, hyperuricemia and sciatica, which has good therapeutic effects, an effective rate of up to 92.01%, and has abundant drug sources, low prices, simple preparation methods, and no side effects.

[0007] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0008] The invention provides a traditional Chinese medicine composition for treating rheumatism, gout, hyperuricemia and sciatica. The traditional Chinese medicine composition comprises the following components by weight: 4-6 parts of artificial bezoars, 8-12 parts of notopterygium root, 8-12 parts of turmeric, 8-12 parts of salvia miltiorrhiza, 8-12 parts of myrrh, 2-4 parts of Scutellaria barbata, 7-9 parts of Clematidis, 8-12 parts of processed Chuanwu, 10-14 parts of white peony root, 10-14 parts of red peony root, 8-12 parts of trigonosciadium japonicum, 7-9 parts of zedoaria, 2-4 parts of gecko, 10-12 parts of frankincense, 12-16 parts of epimedium and 5-10 parts of ginger.

[0009] Preferably, the invention comprises the following components by weight: 5 parts of artificial bezoar, 10 parts of notopterygium, 10 parts of turmeric, 10 parts of salvia miltiorrhiza, 10 parts of myrrh, 3 parts of Scutellaria barbata, 8 parts of Clematidis, 10 parts of processed Chuanwu, 12 parts of white peony root, 12 parts of red peony root, 10 parts of Trillium, 8 parts of Curcuma, 4 parts of Gecko, 10 parts of frankincense, 12 parts of Epimedium and 5 parts of ginger.

[0010] The present invention also provides a method for preparing the above-mentioned Chinese medicine composition, comprising the following steps:

[0011] The components are crushed, sterilized, mixed, and boiled with water to form an ointment; the ointment is dried, cooled, sterilized, and then powdered.

[0012] Preferably, each component is crushed and passed through a 40-80 mesh sieve.

[0013] Preferably, in the boiling process, the amount of water added is 5 to 10 mL / g, and the boiling time is 3 to 5 hours.

[0014] Preferably, the ointment is placed in an oven evaporator for drying, the drying temperature is 30° C. to 50° C., and the drying time is 25 to 30 minutes.

[0015] Preferably, the sterilization is microwave sterilization.

[0016] Preferably, the microwave sterilization has a microwave frequency of 900-950 MHz, a temperature of 60° C.-80° C., and a time of 3-5 min.

[0017] The present invention also provides a medicine for treating rheumatism, gout, hyperuricemia and sciatica, and the medicine comprises the above-mentioned traditional Chinese medicine composition.

[0018] Preferably, the content of the traditional Chinese medicine composition is 50wt% to 100wt%.

[0019] Compared with the prior art, the technical solution of the present invention has the following beneficial effects:

[0020] The invention exerts the effects of promoting blood circulation and removing blood stasis, dispelling wind and dampness, removing wind-cold and dampness, activating collaterals and relieving pain through the synergistic effect of various drugs. It has good therapeutic effects on rheumatoid arthritis (including rheumatoid arthritis and rheumatic chorea), sciatica, gout and hyperuricemia. In addition, the raw material drug source of the invention is abundant and low in price, and the preparation method is simple and easy to operate. The total effective rate of treatment can reach 92.01%, and there is no adverse reaction. DETAILED DESCRIPTION

[0021] The invention provides a traditional Chinese medicine composition for treating rheumatism, gout, hyperuricemia and sciatica. The traditional Chinese medicine composition comprises the following components by weight: 4-6 parts of artificial bezoars, 8-12 parts of notopterygium root, 8-12 parts of turmeric, 8-12 parts of salvia miltiorrhiza, 8-12 parts of myrrh, 2-4 parts of Scutellaria barbata, 7-9 parts of Clematidis, 8-12 parts of processed Chuanwu, 10-14 parts of white peony root, 10-14 parts of red peony root, 8-12 parts of trigonosciadium japonicum, 7-9 parts of zedoaria, 2-4 parts of gecko, 10-12 parts of frankincense, 12-16 parts of epimedium and 5-10 parts of ginger. Preferably, it includes the following components: 5 parts of artificial bezoar, 10 parts of Notopterygium, 10 parts of Curcuma, 10 parts of Salvia miltiorrhiza, 10 parts of Myrrh, 3 parts of Scutellaria barbata, 8 parts of Clematidis, 10 parts of processed Chuanwu, 12 parts of White Peony Root, 12 parts of Red Peony Root, 10 parts of Trillium, 8 parts of Curcuma, 4 parts of Gecko, 10 parts of Olibanum, 12 parts of Epimedium and 5 parts of ginger.

[0022] The raw materials used in the Chinese medicine composition of the present invention are introduced as follows:

[0023] Artificial bezoar is made from ox bile powder, bile acid, hyodeoxycholic acid, taurine, bilirubin, cholesterol, trace elements, etc. It tastes sweet, is cool in nature, and enters the heart and liver meridians. It has the effects of clearing away heat and detoxifying, resolving phlegm and calming the nerves. It is mainly used to treat phlegm-heat delirium, coma and aphasia, acute convulsions in children, sore throat, mouth sores, carbuncles and boils.

[0024] Qianghuo, the dried rhizome and root of Notopterygium incisum Ting ex HTChang or Notopterygium franchetii H. de Boiss. of the Umbelliferae family. It is warm in nature, pungent and bitter in taste; it enters the bladder meridian and kidney meridian. It belongs to the pungent and warm antipyretic medicine under the category of antipyretic medicine. It has the effects of relieving cold, dispelling wind and dampness, and relieving pain. It can be used for antipyretic, analgesic, anti-inflammatory, anti-allergic, anti-myocardial ischemia, anti-arrhythmia, anti-thrombosis, anti-epileptic, antioxidant, antibacterial, prolonging sleep time, and inhibiting cancer.

[0025] Turmeric is the dried rhizome of Curcuma longa L., a plant of the genus Curcuma in the Zingiberaceae family. It tastes pungent and bitter, and is cold in nature. It enters the liver, gallbladder, and heart meridians. It has the effects of promoting blood circulation and qi, relieving pain through menstruation. It is mainly used to treat pain caused by qi stagnation and blood stasis, and rheumatic arthralgia.

[0026] Danshen is the root and rhizome of Salvia miltiorrhiza Bge., a plant of the Labiatae family. It is slightly cold in nature and bitter in taste. It enters the heart meridian and liver meridian. It is a blood-activating and menstruation-regulating drug classified under the blood-activating and stasis-removing drug. It has the effects of removing blood stasis and relieving pain, activating blood circulation and dysmenorrhea, and clearing the heart and removing vexation. It is commonly used to treat irregular menstruation, amenorrhea and dysmenorrhea, accumulation of lumps and masses, stabbing pain in the chest and abdomen, pain caused by heat arthralgia, swelling and toxicity of sores and ulcers, restlessness and insomnia; hepatosplenomegaly, and angina pectoris.

[0027] Frankincense is an oleoresin exuded from the bark of Boswellia carterli Birdw. and several species of the same genus in the Oleaceae family. It is warm in nature, pungent and bitter in taste. It enters the heart meridian, spleen meridian, and liver meridian. It is a blood-activating and analgesic drug classified under the blood-activating and stasis-removing drug category. It has the effects of regulating qi and activating blood circulation, relieving pain, reducing swelling, and promoting tissue regeneration. It is commonly used to treat qi and blood stasis, heart and abdominal pain, carbuncle swelling, traumatic injury, rheumatic arthralgia, dysmenorrhea, and postpartum blood stasis and stinging pain.

[0028] Myrrh is the dried resin of Commiphora myrrha Engl. and Commiphoramolmol Engl., plants of the Oleaceae family. It is mild in nature, pungent and bitter in taste. It enters the heart meridian, liver meridian, and spleen meridian. It is a blood-activating and analgesic drug classified under the blood-activating and stasis-removing drug category. It has the effects of dispersing blood stasis, relieving pain, and reducing swelling and promoting tissue regeneration. It is commonly used for chest pain, heart pain, stomach pain, dysmenorrhea, amenorrhea, postpartum blood stasis, abdominal pain due to stagnation, rheumatic pain, traumatic injuries, carbuncle, swelling, and ulcers.

[0029] Scutellaria barbata, the whole herb of Scutellaria barbata D. Don., a plant of the Labiatae family. It tastes pungent and bitter, and is cold in nature. It enters the lung meridian, liver meridian, and kidney meridian. It is a heat-clearing and detoxifying drug under the category of heat-clearing drugs. It has the effects of clearing heat and detoxifying, promoting blood circulation and removing blood stasis, and diuresis. It can be used to treat ascites caused by late-stage schistosomiasis, ascites caused by liver cirrhosis, snake bites, sores, furuncles, and carbuncles.

[0030] Clematis chinensis Osbeck., Clematis chinensis Osbeck., Clematis manshurica Rupr. or Clematis chinensis Osbeck., all of the Ranunculaceae family. It is warm in nature, pungent and salty in taste; it belongs to the bladder meridian. It is a rheumatism-relieving and cold-dispelling medicine under the category of rheumatism-relieving. It has the effects of dispelling wind and dampness, unblocking meridians and relieving pain. It can be used for analgesia, gallbladder-promoting, inducing labor, anti-microbial, anti-diuretic, and lowering blood pressure.

[0031] Processed Chuanwu, the processed product of Chuanwu, tastes pungent, bitter and hot; it enters the heart, liver, kidney and spleen meridians. It has the effects of dispelling wind and dampness, warming the meridians and relieving pain. It is mainly used to treat wind-cold-dampness arthralgia, joint pain, cold pain in the heart and abdomen, pain caused by cold hernia, pain caused by falls and injuries, and anesthesia and pain relief.

[0032] White peony root is the root of Paeonia lactiflora Pall. of the Ranunculaceae family. It is slightly cold in nature, bitter and sour in taste. It enters the liver meridian and spleen meridian. It is a blood tonic under the category of tonic drugs. It has the effects of calming the liver and relieving pain, nourishing blood and regulating menstruation, and restraining yin and stopping sweating. It is commonly used to treat headache and dizziness, chest and flank pain, diarrhea and abdominal pain, spontaneous sweating and night sweats, fever due to yin deficiency, irregular menstruation, metrorrhagia, leucorrhea, etc.

[0033] Red peony root is the root of Paeonia veitchii Lynch. of the Ranunculaceae family. It is slightly cold in nature and bitter in taste. It enters the liver meridian and spleen meridian. It belongs to the heat-clearing and blood-cooling medicine under the category of heat-clearing medicine. It is used to treat fever-induced rash, vomiting blood and epistaxis, eye swelling and pain, liver depression and hypochondriac pain, amenorrhea and dysmenorrhea, abdominal pain due to lumps and masses, injuries from falls, carbuncles, swellings and ulcers.

[0034] Sparganium is the tuber of Sparganium stoloniferum Buch.-Ham. of the family Sparganium. It is mild in nature, pungent and bitter in taste. It enters the liver meridian and spleen meridian. It belongs to the blood-activating and stasis-removing medicine, which is classified as a blood-breaking and stagnation-removing medicine. It has the effects of breaking blood and promoting qi, removing stagnation and relieving pain. It is often used to treat stagnation and lumps, blood stasis and amenorrhea, food stagnation and pain, heart and stomach pain, dysmenorrhea, and traumatic injuries.

[0035] Curcuma zedoaria, the dried rhizome of the ginger family plants Curcuma zedoaria, Curcuma guangxiensis or Curcuma wenyujin. It is warm in nature, pungent and bitter in taste. It enters the spleen meridian and liver meridian. It belongs to the blood-activating and blood-stasis-removing medicine, which is a blood-breaking and stagnation-removing medicine. It has the effects of promoting qi and removing blood, removing stagnation and relieving pain. It is often used to treat stagnation and lumps, blood stasis and amenorrhea, food stagnation and pain, and early cervical cancer.

[0036] Gecko is the whole body of Gekko gecko (Linnaeus), an animal of the family Gekko. It is neutral in nature and salty in taste. It enters the lung and kidney meridians. It is a yang-tonifying medicine under the category of tonic medicine. It has the effects of tonifying the lung and kidney, relieving asthma, and helping to block and benefit the essence. It is used to treat asthma, shortness of breath, cough due to fatigue, and hemoptysis, as well as impotence and spermatorrhea.

[0037] Epimedium, the leaves of Epimedium Brevicornu Max-Im., Epimedium sagittatum (Sieb. et Zucc.) Maxim., Epimedium pubescens Maxim. or Epimedium koreanum Nakai, all of the Berberidaceae family. It is warm in nature, pungent and sweet in taste; it enters the liver meridian and kidney meridian. It is a yang-tonifying drug under the category of tonic drugs. It has the effects of tonifying kidney yang, strengthening tendons and bones, and removing rheumatism. It is used to treat impotence and spermatorrhea, weakness of tendons and bones, rheumatic pain, numbness and cramps; and menopausal hypertension.

[0038] Ginger is the fresh rhizome of Zingiber offcinale Rosc., a plant of the ginger family. It is slightly warm in nature and pungent in taste. It enters the lung meridian, spleen meridian, and stomach meridian. It is a pungent and warm antipyretic drug under the category of antipyretic drugs. It has the effects of dispelling cold and relieving exterior symptoms, relieving adverse reactions and vomiting, resolving phlegm and relieving cough, and detoxifying fish and crabs. It can be used for colds caused by wind and cold, vomiting caused by stomach cold, cough caused by cold phlegm, and fish and crab poisoning.

[0039] In the present invention, each drug synergistically exerts the effects of promoting blood circulation and removing blood stasis, dispelling wind and dampness, wind-cold and dampness, activating collaterals and relieving pain. Polyglycosides such as Notopterygium, Curcuma longa, White Peony Root, Red Peony Root, and Tripterygium wilfordii directly inhibit the activation and proliferation of immune cells, and then with other prepared Chinese medicines as a supplement, reduce the level of immunoglobulins and autoantibodies, thereby alleviating joint inflammation and damage. Chinese medicines such as artificial bezoar, Salvia miltiorrhiza, Myrrha, Scutellaria barbata, Clematidis, Tripterygium wilfordii, Curcuma zedoaria, and ginger regulate uric acid metabolism by inhibiting uric acid production and promoting uric acid excretion. Inhibiting xanthine oxidase activity reduces uric acid production, and increases kidney excretion of uric acid, maintains blood uric acid levels within a normal range, prevents urate crystals from depositing in joints and surrounding tissues, and avoids the onset and progression of gouty arthritis. The various components in the Chinese medicine of the present invention inhibit inflammatory reactions through multiple pathways, regulate the functions of inflammatory cells, such as the phagocytic activity and polarization state of macrophages, transform them from pro-inflammatory to anti-inflammatory, and promote the disappearance of inflammation.

[0040] After the active ingredients of the Chinese medicine composition of the present invention reach the lesion site, they exert therapeutic effects through mechanisms such as anti-inflammatory, immune regulation and regulation of uric acid metabolism. In the local joint, the inflammatory reaction is reduced, pain and swelling are relieved, and the recovery of joint function is promoted. Regulating immune function helps to repair damaged joint tissue and prevent further development of the disease. Regulating uric acid metabolism fundamentally prevents the onset of gout and reduces the damage of urate crystals to the joints. A good therapeutic effect on rheumatoid arthritis (including rheumatoid arthritis, rheumatic chorea), sciatica, gout, and hyperuricemia is achieved.

[0041] The invention also provides a method for preparing the Chinese medicine composition, comprising the following steps: crushing and sterilizing the components, mixing and boiling with water to form an ointment; drying and cooling the ointment, and powdering after sterilization.

[0042] In the present invention, each raw material component is pulverized separately and pulverized through a 40-80 mesh sieve. The obtained raw material powder is sterilized, and the sterilization is microwave sterilization, and the microwave frequency of the microwave sterilization is 900-950MHz, preferably 915MHz, the temperature is 60℃-80℃, and the time is 3-5min. The present invention uses microwave sterilization to ensure that various microorganisms including spores, molds, yeasts, Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa in the raw materials are completely killed. The sterilized medicinal powder is mixed evenly in proportion, and water is added to boil into a paste. The amount of water added is 5-10mL / g, preferably 6-8mL / g, and the boiling time is 3-5h, preferably 4h. The boiled ointment is dried, preferably placed in an oven evaporator for drying, the drying temperature is 30-50℃, preferably 32℃, and the drying time is 25-30min, preferably 28min. After the ointment is dried, it is cooled to room temperature and sterilized. The sterilization is microwave sterilization. The microwave frequency of the microwave sterilization is 900-950MHz, preferably 915MHz, the temperature is 60℃-80℃, and the time is 3-5min. After sterilization and disinfection, powder packaging is performed to obtain the Chinese medicine composition preparation. The powder state of the Chinese medicine composition obtained by the present invention increases the surface area of ​​the drug, is conducive to the dissolution and absorption of the effective ingredients, and improves the bioavailability. In addition, some ingredients may undergo physical or chemical changes during the powdering process, produce new activities or enhance the original activities. And the Chinese medicine composition preparation of the present invention is easy to carry and store, suitable for long-term use, especially for the compliance improvement of patients with chronic diseases. It is very helpful. The preparation of the present invention is preferably a powder capsule. As an optional embodiment, the present invention is 30 capsules per bag, 0.5g per capsule, and is packaged in bags and sealed in moisture-proof bags, and stored after quality inspection.

[0043] The present invention also provides a medicine for treating rheumatism, gout, hyperuricemia and sciatica, the medicine comprising the above-mentioned Chinese medicine composition; the content of the Chinese medicine composition is 50-100wt%, preferably 80-99wt%. The medicine of the present invention may also include a pharmaceutically acceptable carrier, and a pharmaceutically acceptable pharmaceutical excipient is added to the medicine to ensure that the prepared medicine is convenient for preparation and clinical application.

[0044] The technical solutions in the present invention will be described clearly and completely below in conjunction with the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0045] In the following embodiments, unless otherwise specified, all of them are conventional methods.

[0046] Unless otherwise specified, the materials and reagents used in the following examples can be obtained from commercial sources.

[0047] Example 1

[0048] A traditional Chinese medicine composition for treating rheumatism, gout, hyperuricemia and sciatica, comprising the following raw materials: 5g of artificial bezoar, 10g of notopterygium root, 10g of turmeric, 10g of salvia miltiorrhiza, 10g of myrrh, 3g of Scutellaria barbata, 8g of Clematidis, 10g of processed Chuanwu, 12g of white peony root, 12g of red peony root, 10g of Trigonosciadium japonicum, 8g of Curcuma zedoaria, 4g of Gecko, 10g of frankincense, 12g of epimedium and 5g of ginger.

[0049] The preparation method is:

[0050] Weigh each raw material separately, crush it, and pass it through a 50-mesh sieve. The obtained raw material powder is sterilized by microwave. The sterilized medicinal powder is mixed evenly according to the proportion, and 1000mL of water is added to boil for 3-5 hours to form a paste. The boiled ointment is placed in an oven evaporator and dried at 30℃ for 25 minutes to remove excess water. After the ointment is dried, it is cooled to room temperature and sterilized by microwave. The microwave frequency of microwave sterilization is 915MHz, the temperature is 70℃, and the time is 4min. After sterilization, powder is packaged to obtain powder capsules. According to 30 capsules per bag, each capsule is 0.5g, and they are packaged in bags and sealed in moisture-proof bags, and put into storage after quality inspection.

[0051] Example 2

[0052] A traditional Chinese medicine composition for treating rheumatism, gout, hyperuricemia and sciatica, comprising the following raw materials: 4g artificial bezoar, 8g notopterygium root, 8g turmeric, 8g salvia miltiorrhiza, 8g myrrh, 2g Scutellaria barbata, 7g clematis root, 8g processed Chuanwu, 10g white peony root, 10g red peony root, 8g trillium, 7g curcuma, 2g gecko, 10g frankincense, 12g epimedium and 8g ginger.

[0053] The preparation method is:

[0054] Weigh each raw material separately, crush it, and pass it through a 40-mesh sieve. The obtained raw material powder is sterilized by microwave. The sterilized medicinal powder is mixed evenly according to the proportion, and 1000mL of water is added to boil for 3-5 hours to form a paste. The boiled ointment is placed in an oven evaporator and dried at 30℃ for 25 minutes to remove excess water. After the ointment is dried, it is cooled to room temperature and sterilized by microwave. The microwave frequency of microwave sterilization is 915MHz, the temperature is 80℃, and the time is 3min. After sterilization, powder is packaged to obtain powder capsules. According to 30 capsules per bag, each capsule is 0.5g, and they are packaged in bags and sealed in moisture-proof bags, and put into storage after quality inspection.

[0055] Example 3

[0056] A traditional Chinese medicine composition for treating rheumatism, gout, hyperuricemia and sciatica, comprising the following raw materials: 6g of artificial bezoar, 12g of notopterygium root, 12g of turmeric, 12g of salvia miltiorrhiza, 12g of myrrh, 4g of Scutellaria barbata, 9g of Clematidis, 12g of processed Chuanwu, 14g of white peony root, 14g of red peony root, 12g of Trigonosciadium japonicum, 9g of Curcuma zedoaria, 4g of Gecko, 12g of frankincense, 16g of epimedium and 10g of ginger.

[0057] The preparation method is:

[0058] Weigh each raw material separately, crush it, and pass it through an 80-mesh sieve. The obtained raw material powder is sterilized by microwave. The sterilized medicinal powder is mixed evenly according to the proportion, and 1000mL of water is added to boil for 3-5 hours to form a paste. The boiled ointment is placed in an oven evaporator and dried at 30℃ for 25 minutes to remove excess water. After the ointment is dried, it is cooled to room temperature and sterilized by microwave. The microwave frequency of microwave sterilization is 915MHz, the temperature is 60℃, and the time is 5min. After sterilization, powder is packaged to obtain powder capsules. According to 30 capsules per bag, each capsule is 0.5g, and they are packaged in bags and sealed in moisture-proof bags, and put into storage after quality inspection.

[0059] Example 4

[0060] A traditional Chinese medicine composition for treating rheumatism, gout, hyperuricemia and sciatica, comprising the following raw materials: 4g artificial bezoar, 12g Notopterygium wilfordii, 8g turmeric, 12g salvia miltiorrhiza, 12g myrrh, 2g Scutellaria barbata, 9g clematis, 8g processed Chuanwu, 10g white peony root, 14g red peony root, 8g trillium, 9g zedoaria, 4g gecko, 10g frankincense, 12g epimedium and 8g ginger.

[0061] The preparation method is:

[0062] Weigh each raw material separately, crush it, and pass it through an 80-mesh sieve. The obtained raw material powder is sterilized by microwave. The sterilized medicinal powder is mixed evenly according to the proportion, and 1000mL of water is added to boil for 3-5 hours to form a paste. The boiled ointment is placed in an oven evaporator and dried at 30℃ for 25 minutes to remove excess water. After the ointment is dried, it is cooled to room temperature and sterilized by microwave. The microwave frequency of microwave sterilization is 915MHz, the temperature is 75℃, and the time is 4min. After sterilization, powder is packaged to obtain powder capsules. According to 30 capsules per bag, each capsule is 0.5g, and they are packaged in bags and sealed in moisture-proof bags, and put into storage after quality inspection.

[0063] Example 5

[0064] A traditional Chinese medicine composition for treating rheumatism, gout, hyperuricemia and sciatica, comprising the following raw materials: 5g of artificial bezoar, 10g of notopterygium root, 10g of turmeric, 10g of salvia miltiorrhiza, 10g of myrrh, 3g of Scutellaria barbata, 8g of Clematidis, 10g of processed Chuanwu, 12g of white peony root, 12g of red peony root, 10g of Trigonosciadium japonicum, 8g of Curcuma zedoaria, 3g of Gecko, 12g of frankincense, 14g of Epimedium and 9g of ginger.

[0065] The preparation method is:

[0066] Weigh each raw material separately, crush it, and pass it through an 80-mesh sieve. The obtained raw material powder is sterilized by microwave. The sterilized medicinal powder is mixed evenly according to the proportion, and 1000mL of water is added to boil for 3-5 hours to form a paste. The boiled ointment is placed in an oven evaporator and dried at 30℃ for 25 minutes to remove excess water. After the ointment is dried, it is cooled to room temperature and sterilized by microwave. The microwave frequency of microwave sterilization is 915MHz, the temperature is 65℃, and the time is 4min. After sterilization, powder is packaged to obtain powder capsules. According to 30 capsules per bag, each capsule is 0.5g, and they are packaged in bags and sealed in moisture-proof bags, and put into storage after quality inspection.

[0067] Example 6

[0068] A traditional Chinese medicine composition for treating rheumatism, gout, hyperuricemia and sciatica, comprising the following raw materials: 6g of artificial bezoar, 8g of notopterygium root, 12g of turmeric, 8g of salvia miltiorrhiza, 8g of myrrh, 4g of Scutellaria barbata, 7g of Clematidis, 12g of processed Chuanwu, 14g of white peony root, 10g of red peony root, 12g of Trigonosciadium japonicum, 7g of Curcuma zedoaria, 4g of Gecko, 12g of frankincense, 16g of Epimedium and 6g of ginger.

[0069] The preparation method is:

[0070] Weigh each raw material separately, crush it, and pass it through an 80-mesh sieve. The obtained raw material powder is sterilized by microwave. The sterilized medicinal powder is mixed evenly according to the proportion, and 1000mL of water is added to boil for 3-5 hours to form a paste. The boiled ointment is placed in an oven evaporator and dried at 30℃ for 25 minutes to remove excess water. After the ointment is dried, it is cooled to room temperature and sterilized by microwave. The microwave frequency of microwave sterilization is 915MHz, the temperature is 60℃, and the time is 3min. After sterilization and disinfection, powder packaging is carried out to obtain powder capsules. According to 30 capsules per bag, each capsule is 0.5g, and they are packaged in bags and sealed in moisture-proof bags, and put into storage after quality inspection.

[0071] Test example

[0072] Clinical observation was carried out using the drug prepared in Example 1:

[0073] 1. Case selection: rheumatoid arthritis, rheumatic chorea, sciatica, gout, hyperuricemia, and internal rheumatoid arthritis.

[0074] A total of 513 cases were treated, including 308 males and 205 females aged between 13 and 81 years old.

[0075] 2. Treatment methods:

[0076] Take the prepared medicine, open the medicine bag, and take it with an appropriate amount of warm water, twice a day, once in the morning and evening, 2 capsules each time, 0.5g each capsule. Beer, seafood, and bean products are prohibited during this period.

[0077] 3. Criteria for determining efficacy

[0078] According to the "Standards for Diagnosis and Efficacy of Traditional Chinese Medicine Diseases", the degree of improvement of symptoms and physical signs is used as the standard for judging efficacy, which is divided into:

[0079] (1) Significant effect: symptoms are significantly improved;

[0080] Joint pain: changes from unbearable severe pain to mild pain or only occasional dull pain, or the frequency of pain attacks decreases, indicating a significant effect.

[0081] Joint swelling: Joint swelling, redness and fever are common symptoms of gout. When the swelling gradually subsides, the skin color returns to normal and the skin temperature decreases, it indicates that the inflammation is decreasing and the treatment is improving.

[0082] Blood uric acid level: Blood uric acid level is an important indicator for judging the condition of gout. Generally speaking, blood uric acid can remain stable below 360μmol / L. For patients with gout, blood uric acid can be continuously controlled below 300μmol / L, indicating that gout is well controlled.

[0083] Imaging tests

[0084] Ultrasound examination: The deposition of urate crystals in the joints can be observed. If ultrasound shows a decrease in urate crystals, a decrease in joint effusion, and a decrease in synovial thickening after treatment, it means that gout has improved.

[0085] Dual-energy CT examination: It can more intuitively display the distribution and number of urate crystals. If the examination finds that the volume and number of urate crystals are significantly reduced, it indicates that the disease is under control.

[0086] (2) Effective: Symptoms have improved to a certain extent. During a gout attack, the joints are in great pain. If the pain is greatly reduced and the duration is shortened, these are signs of improvement.

[0087] Mobility function: If the joint movement was originally limited due to pain and swelling, such as inability to flex and extend normally, difficulty walking, etc., and now the joint movement is gradually returning to normal, the range of motion is increased, and the pain is not obvious, it is also a sign that gout is effectively improving.

[0088] (3) Ineffective: No changes in any aspect compared with before medication.

[0089] 4. Therapeutic effect

[0090] Table 1 Treatment effect of 1513 patients

[0091]

[0092] The results showed that among 513 patients who used the drug of the present invention, 472 were markedly effective, 472 were effective (all effective cases showed marked effectiveness), 41 were ineffective, and the total effective rate was 92.01%. All cases had no adverse reactions.

[0093] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating rheumatism, gout, hyperuricemia and sciatica, characterized in that: The invention comprises the following components by weight: 4-6 parts of artificial bezoar, 8-12 parts of notopterygium root, 8-12 parts of turmeric, 8-12 parts of salvia miltiorrhiza, 8-12 parts of myrrh, 2-4 parts of Scutellaria barbata, 7-9 parts of Clematidis, 8-12 parts of processed Chuanwu, 10-14 parts of white peony root, 10-14 parts of red peony root, 8-12 parts of Trillium, 7-9 parts of Curcuma, 2-4 parts of Gecko, 10-12 parts of frankincense, 12-16 parts of Epimedium and 5-10 parts of ginger.

2. The Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following components by weight: 5 parts of artificial bezoar, 10 parts of notopterygium root, 10 parts of turmeric, 10 parts of salvia miltiorrhiza, 10 parts of myrrh, 3 parts of Scutellaria barbata, 8 parts of clematis root, 10 parts of processed Chuanwu, 12 parts of white peony root, 12 parts of red peony root, 10 parts of trillium, 8 parts of curcuma, 4 parts of gecko, 10 parts of frankincense, 12 parts of epimedium and 5 parts of ginger.

3. The method for preparing the Chinese medicine composition according to claim 1 or 2, characterized in that: The following steps are involved: The components are crushed, sterilized, mixed, and boiled with water to form an ointment; the ointment is dried, cooled, sterilized, and then powdered.

4. The preparation method according to claim 3, characterized in that: Each component was crushed and passed through a 40-80 mesh sieve.

5. The preparation method according to claim 3, characterized in that: In the boiling process, the amount of water added is 5 to 10 mL / g, and the boiling time is 3 to 5 hours.

6. The preparation method according to claim 3, characterized in that: The ointment is placed in an oven evaporation box for drying, the drying temperature is 30° C. to 50° C., and the drying time is 25 to 30 minutes.

7. The preparation method according to claim 3, characterized in that: The sterilization is microwave sterilization.

8. The preparation method according to claim 7, characterized in that: The microwave sterilization has a microwave frequency of 900-950 MHz, a temperature of 60° C.-80° C., and a time of 3-5 minutes.

9. A medicine for treating rheumatism, gout, hyperuricemia, and sciatica, characterized in that: The medicine comprises the Chinese medicine composition according to claim 1 or 2.

10. The drug according to claim 9, characterized in that The content of the traditional Chinese medicine composition is 50wt% to 100wt%.

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