Microneedle patch dosing device and dosing method

Abstract

The invention discloses a microneedle patch dosing device and a dosing method, and belongs to the technical field of medical instruments. The device comprises: a housing; the reset rotating rod assembly comprises a rotating rod and a release rod; the rotating rod extends into an inner hole of the shell from the top of the shell, a rotating rod hole is formed in the bottom of the rotating rod, the release rod is installed in the rotating rod hole through a release rod reset spring, and the bottom of the release rod is used for containing a microneedle patch; the push rod is mounted in an inner hole of the shell through a compression spring; the rotating rod is inserted into the push rod; the pressing sleeve is movably arranged at the bottom of the shell in a sleeving manner; according to the microneedle patch dosing device, elastic potential energy of the compression spring is released, so that the push rod punctures and fits the microneedle patch to the surface of human skin with constant impact force, the pressing force applied to the microneedle patch is uniformly distributed, and the depth of the microneedle patch punctured into the human skin is consistent.

Description

Technical Field

[0001] The present invention relates to the technical field of medical devices, and in particular to a microneedle patch drug delivery device and a drug delivery method. Background Art

[0002] In the field of medical devices, microneedle patch drug delivery is a new type of transdermal drug delivery method. The microneedle patch looks like a "Band-Aid" with grooves filled with liquid medicine and tiny needles on the surface. As long as it is pressed on the skin surface, these tiny needles will pass through the outermost stratum corneum of the skin and deliver the liquid medicine to the subcutaneous cells of the human body. Compared with traditional drug delivery routes, such as injection and oral administration, it has the advantages of rapid drug delivery, less pollution, no pain, and less infection.

[0003] The existing technology is to manually attach the microneedle patch to the skin surface, and then press the back of the microneedle patch with fingers to make the microneedles on the microneedle patch penetrate the stratum corneum of the skin to dissolve the drug solution and transport it to the human body.

[0004] It is difficult to control the pressure when manually applying and pressing the microneedle patch. The pressure cannot be evenly distributed on the microneedle patch, which makes the depth of microneedle penetration into the skin inconsistent, and even fails to penetrate the dermis, resulting in falling off. However, the microneedle patch needs to be attached to the skin surface for a long time to ensure that the microneedle can dissolve. This drug delivery method is very challenging for the operator's operational accuracy and is time-consuming and labor-intensive. Summary of the invention

[0005] The object of the present invention is to provide a microneedle patch drug delivery device and a drug delivery method, so that the microneedle patch can be flatly attached to the surface of human skin with a certain force, and each microneedle unit on the microneedle patch is evenly stressed and penetrates the skin to a consistent depth.

[0006] In order to solve the above technical problems, the present invention provides a microneedle patch applicator, comprising:

[0007] shell;

[0008] The reset rotary rod assembly comprises a rotary rod, a release rod and a release rod reset spring; the rotary rod extends from the top of the housing into the inner hole thereof, a rotary rod hole is provided at the bottom of the rotary rod, and the release rod and the release rod reset spring are both installed in the rotary rod hole;

[0009] A push rod, which and the compression spring are both installed in the inner hole of the housing; the rotary rod is inserted into the push rod, and the bottom of the push rod is used to stick the microneedle patch;

[0010] A pressing sleeve, the movable sleeve of which is arranged at the bottom of the shell;

[0011] in:

[0012] A spring pin is installed on the rotating rod, and a reset slide groove is provided on the push rod. One end of the spring pin contacts the outer column wall of the release rod, and the other end extends into the reset slide groove.

[0013] The pressing sleeve is provided with a pressing sleeve pin hole, the outer shell is provided with a vertically arranged connecting pin slot, the release rod is provided with a release rod pin hole, and the connecting pin passes through the pressing sleeve pin hole and the connecting pin slot and is inserted into the release rod pin hole.

[0014] Preferably, a limiting groove is provided on the rotating rod;

[0015] The push rod is provided with a vertical push rod anti-rotation limiting slide groove;

[0016] The shell is provided with a shell pin hole; a spring pin installation hole

[0017] The rotating rod clamping pin passes through the pin hole of the shell and the push rod anti-rotation limiting sliding groove and is inserted into the limiting groove.

[0018] Preferably, two ends of the spring pin are connected to the release rod and the push rod respectively through spring sheets.

[0019] Preferably, the side wall of the rotary rod is provided with a hole connected to the rotary rod;

[0020] A spring pin fixing block is installed on the spring pin installation hole;

[0021] The spring pin is installed on the spring pin fixing block.

[0022] Preferably, the release rod is provided with an annular diameter-changing groove;

[0023] One end of the spring pin is always in contact with the diameter-changing groove under the action of the spring sheet.

[0024] Preferably, the inner hole of the shell includes a small shallow hole section and a large deep hole section arranged in sequence from top to bottom;

[0025] The rotary rod passes through the small shallow hole section and then extends into the large deep hole section.

[0026] Preferably, a shell step is formed between the small shallow hole section and the large deep hole section;

[0027] One end of the compression spring is connected to the housing step, and the other end is connected to the push rod;

[0028] The rotary rod passes through the compression spring.

[0029] Preferably, a rotating rod head is provided on the top of the rotating rod;

[0030] The diameter of the rotary rod head is larger than the diameter of the small shallow hole section.

[0031] Preferably, the reset chute comprises a spiral section and a vertical section;

[0032] The top of the spiral section is connected to the top of the vertical section;

[0033] The outer surface of the housing is provided with a gripping portion and a pressing sleeve sliding portion in sequence from top to bottom;

[0034] The pressing sleeve is sleeved on the pressing sleeve sliding part.

[0035] The present invention also provides a drug delivery method of a microneedle patch drug delivery device, comprising the following steps:

[0036] The microneedle patch is pasted on the push rod end face of the microneedle patch applicator, and the rotating rod of the microneedle patch applicator is rotated. The spring pin extending from the rotating rod is stuck in the push rod reset slide groove, driving the push rod to retract, and the push rod is retracted into the pressing sleeve of the microneedle patch applicator;

[0037] When the recipient receives the medicine, the end face of the pressing sleeve is pressed against the skin surface of the recipient, and the pressing sleeve drives the release rod to move toward the rotating rod side through the connecting pin. The spring pin approaches the axis of the rotating rod under the action of the spring sheet and disengages from the reset slide groove of the push rod, whereupon the limiting effect of the spring pin on the push rod is released, and the push rod pops forward under the action of the compression spring, driving the microneedle patch on the end face of the push rod to impact the skin surface of the recipient.

[0038] Compared with the prior art, the present invention has the following beneficial effects:

[0039] The microneedle patch applicator of the present invention releases the elastic potential energy of the compression spring so that the push rod can penetrate the microneedle patch with a constant impact force and fit it to the surface of human skin. The pressing force on the microneedle patch is evenly distributed and the penetration depth of the microneedle patch into the human skin is consistent. BRIEF DESCRIPTION OF THE DRAWINGS

[0040] The specific implementation modes of the present invention are further described in detail below with reference to the accompanying drawings.

[0041] Figure 1 It is a schematic diagram of the three-dimensional structure of a microneedle patch applicator;

[0042] Figure 2 This is an exploded view of a microneedle patch applicator;

[0043] Figure 3 It is a schematic diagram of the structure in which the push rod is installed in the housing;

[0044] Figure 4 It is a schematic diagram of the structure in which the rotary rod is installed in the housing;

[0045] Figure 5 It is a schematic diagram of the structure of the shell;

[0046] Figure 6 1. It is a structural schematic diagram of the reset rotary rod assembly;

[0047] Figure 7 It is a schematic diagram of the structure of the push rod;

[0048] In the figure:

[0049] 1-housing; 2-rotating rod; 3-releasing rod; 4-rotating rod hole; 5-releasing rod reset spring; 6-push rod; 7-compression spring; 8-pressing sleeve; 9-spring pin; 10-reset slide groove; 11-pressing sleeve pin hole; 12-connecting pin slide groove; 13-releasing rod pin hole; 14-limiting groove; 15-push rod anti-rotation limiting slide groove; 16-housing pin hole; 17-spring sheet; 18-spring pin fixing block; 19-spring pin mounting hole; 20-small shallow hole section; 21-large deep hole section; 22-housing step; 23-rotating rod head; 24-reducing slot; 25-connecting pin; 26-rotating rod pin; 27-microneedle patch; 28-holding part; 29-pressing sleeve sliding part; 30-spiral section; 31-vertical section. DETAILED DESCRIPTION

[0050] Many specific details are set forth in the following description to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways than those described herein, and those skilled in the art can make similar generalizations without violating the connotation of the present invention, so the present invention is not limited to the specific implementation disclosed below.

[0051] The terms used in one or more embodiments of this specification are only for the purpose of describing specific embodiments, and are not intended to limit one or more embodiments of this specification. The singular forms of "a", "said" and "the" used in one or more embodiments of this specification and the appended claims are also intended to include plural forms, unless the context clearly indicates other meanings. It should also be understood that the term "and / or" used in one or more embodiments of this specification refers to and includes any or all possible combinations of one or more associated listed items.

[0052] It should be understood that although the terms first, second, etc. may be used to describe various information in one or more embodiments of this specification, this information should not be limited to these terms. These terms are only used to distinguish the same type of information from each other. For example, without departing from the scope of one or more embodiments of this specification, the first may also be referred to as the second, and similarly, the second may also be referred to as the first. Depending on the context, the word "if" as used herein may be interpreted as "at the time of" or "when" or "in response to determining".

[0053] The present invention is further described in detail below in conjunction with the accompanying drawings:

[0054] The present invention provides a microneedle patch applicator, comprising:

[0055] Shell 1;

[0056] The reset rotary rod assembly comprises a rotary rod 2, a release rod 3 and a release rod reset spring 5; the rotary rod 2 extends from the top of the housing 1 into the inner hole thereof, a rotary rod hole 4 is formed at the bottom of the rotary rod 2, and the release rod 3 and the release rod reset spring 5 are both installed in the rotary rod hole 4;

[0057] The push rod 6 and the compression spring 7 are both installed in the inner hole of the housing 1; the rotary rod 2 is inserted into the push rod 6, and the bottom of the push rod 6 is used to stick the microneedle patch 27;

[0058] A pressing sleeve 8, which is movably mounted on the bottom of the housing 1;

[0059] in:

[0060] A spring pin 9 is installed on the rotary rod 2, and a reset slide groove 10 is provided on the push rod 6. One end of the spring pin 9 contacts the outer column wall of the release rod 3, and the other end extends into the reset slide groove 10.

[0061] The pressing sleeve 8 is provided with a pressing sleeve pin hole 11, the outer shell 1 is provided with a vertically arranged connecting pin slot 12, the release rod 3 is provided with a release rod pin hole 13, and the connecting pin 25 passes through the pressing sleeve pin hole 11 and the connecting pin slot 12 and is inserted into the release rod pin hole 13.

[0062] Preferably, a limiting groove 14 is provided on the rotating rod 2;

[0063] The push rod 6 is provided with a vertical push rod anti-rotation limiting slide groove 15;

[0064] The housing 1 is provided with a housing pin hole 16;

[0065] The rotating rod latch 26 passes through the housing pin hole 16 and the push rod anti-rotation limiting sliding groove 15 and then is inserted into the limiting groove 14 .

[0066] Preferably, both ends of the spring pin 9 are connected to the release rod 3 and the push rod 6 via spring sheets 17 respectively.

[0067] Preferably, a spring pin mounting hole 19 communicating with the rotary rod hole 4 is provided on the side wall of the rotary rod 2;

[0068] A spring pin fixing block 18 is installed on the spring pin installation hole 19;

[0069] The spring pin 9 is mounted on a spring pin fixing block 18 .

[0070] Preferably, the release rod 3 is provided with an annular diameter-changing groove 24;

[0071] One end of the spring pin 9 is always in contact with the diameter-changing groove 24 under the action of the spring sheet 17 .

[0072] Preferably, the inner hole of the housing 1 includes a small shallow hole section 20 and a large deep hole section 21 arranged sequentially from top to bottom;

[0073] The rotary rod 2 passes through the small shallow hole section 20 and then extends into the large deep hole section 21 .

[0074] Preferably, a shell step 22 is formed between the small shallow hole section 20 and the large deep hole section 21;

[0075] One end of the compression spring 7 is connected to the housing step 22, and the other end is connected to the push rod 6;

[0076] The rotary rod 2 passes through the compression spring 7 .

[0077] Preferably, a rotating rod head 23 is provided at the top of the rotating rod 2;

[0078] The diameter of the rotary rod head 23 is larger than the diameter of the small shallow hole section 20 .

[0079] Preferably, the reset chute 10 comprises a spiral section 30 and a vertical section 31;

[0080] The top of the spiral section 30 is connected to the top of the vertical section 31;

[0081] The outer surface of the housing 1 is provided with a gripping portion 28 and a pressing sleeve sliding portion 29 in sequence from top to bottom;

[0082] The pressing sleeve 8 is sleeved on the pressing sleeve sliding portion 29 .

[0083] The present invention also provides a drug delivery method of a microneedle patch drug delivery device, comprising the following steps:

[0084] The microneedle patch 27 is pasted on the end surface of the push rod 6 of the microneedle patch applicator, and the rotating rod 2 of the microneedle patch applicator is rotated, and the spring pin 9 extending from the rotating rod 2 is stuck in the reset slide groove 10 of the push rod 6, driving the push rod 6 to retract, so that the push rod 6 is retracted into the pressing sleeve 8 of the microneedle patch applicator;

[0085] When administering the medicine to the recipient, the end face of the pressing sleeve 8 is pressed against the skin surface of the recipient, and the pressing sleeve 8 drives the release rod 3 to move toward the side of the rotating rod 2 through the connecting pin 25. The spring pin 9 approaches the axis of the rotating rod 2 under the action of the spring sheet 17 and disengages from the reset slide groove 10 of the push rod 6. Then the limiting effect of the spring pin 9 on the push rod 6 is released, and the push rod 6 pops out forward under the action of the compression spring 7, driving the microneedle patch 27 on the end face of the push rod 6 to impact the skin surface of the recipient.

[0086] In order to better illustrate the technical effect of the present invention, the present invention provides the following specific embodiments to illustrate the above technical process:

[0087] Embodiment 1, a microneedle patch applicator, consisting of a housing 1, a push rod 6, a compression spring 7, a reset rotary rod assembly, a reset rotary rod latch 26, a connecting pin 25, and a pressing sleeve 8; wherein the reset rotary rod assembly includes a rotary rod 2, a release rod 3, a release rod reset spring 5, a spring pin 9, a spring pin fixing block 18 and a spring sheet 17.

[0088] The shell 1 of the microneedle patch applicator is a sleeve structure. The inner hole of the shell 1 is composed of a large deep hole section 21 and a small shallow hole section 20. The connection between the large deep hole section 21 and the small shallow hole section 20 forms a shell step 22. The outer wall of the shell 1 is cylindrical and stepped, consisting of a holding part and a pressing sleeve sliding part 29. There is a pressing step at the junction of the two parts. The pressing sleeve sliding part 29 of the shell 1 has a connecting pin 25 slide groove 12 in the shape of a waist hole extending through the shell 1 radially, and the holding part of the shell 1 has a pin hole along the radial direction of the shell 1.

[0089] The reset swing rod assembly is inserted into the small shallow hole section 20 of the outer shell 1. The swing rod 2 in the reset swing rod assembly is a stepped shaft structure composed of two cylinders with different diameters, that is, a swing rod head 23 with a larger diameter is arranged on the top of the swing rod 2, and the part with a smaller diameter of the cylinder can just pass through the small shallow hole section 20 of the outer shell 1, and a limiting groove 14 is arranged on the part with a smaller diameter of the cylinder of the reset swing rod 2. There is a step at the connection between the part with a smaller diameter of the cylinder of the swing rod 2 and the part with a larger diameter, and the end face of the step fits the end face of the outer shell 1. A swing rod hole 4 is opened on the end face of the part with a smaller diameter of the cylinder of the swing rod 2 for placing a release rod reset spring 5 and a release rod 3. One end of the release rod reset spring 5 fits with the end face of the bottom of the deep hole, and the other end fits with the end face of the release rod 3. The reset spring can make the release rod 3 have a force away from the bottom of the deep hole of the swing rod 2. The release rod 3 can slide axially in the deep hole of the rotating rod 2. At the same time, the reset rotating rod assembly is also provided with a spring pin 9, which is fixed on the rotating rod 2 through a spring pin fixing block 18. Under the action of the spring sheet 17, the spring pin 9 always has a force that makes the spring pin 9 rebound along the axis of the rotating rod 2. The spring pin 9 is also affected by the release rod 3. There is a variable diameter profile on the release rod 3, which serves as a variable diameter groove 24. The diameter of the variable diameter groove 24 gradually decreases from top to bottom; the spring pin 9 is affected by the spring sheet 17, which will make one end face of the spring pin 9 fit into the variable diameter groove 24 on the release rod 3. At this point, the release rod 3 slides axially along the rotating rod 2 to control the extension and retraction of the spring pin 9.

[0090] The compression spring 7 is installed inside the shell 1, and one end is fitted with the stepped end surface at the connection between the large deep hole and the small shallow hole of the shell 1. The inner diameter of the compression spring 7 is slightly larger than the diameter of the smaller part of the cylindrical diameter of the reset rotary rod 2, so that the reset rotary rod 2 can pass through the compression spring 7, and the compression spring 7 can give the push rod 6 a force to push outward.

[0091] The push rod 6 is a cylindrical structure, one end is open and the other end is closed. A reset chute 10 and a stop limit chute are provided on the wall of the push rod 6. The push rod 6 is inserted into the housing 1. The open end of the push rod 6 is sleeved on the outer wall of the rotary rod 2 in the reset rotary rod assembly. The spring pin 9 in the reset rotary rod assembly is stuck in the reset chute 10 on the wall of the push rod 6. The end surface of the open end of the push rod 6 just fits the compression spring 7. The reset chute 10 includes a spiral section 30 and a vertical section 31. The top of the spiral section 30 is connected to the top of the vertical section 31. When the recipient receives the medicine, the spring pin 9 first moves along the spiral section 30 of the reset chute 10 from the bottom to the top, and then the spring pin 9 moves from the top of the vertical section 31 to the bottom under the action of the release rod reset spring 5.

[0092] The reset rotary rod pin 26 passes through the shell pin hole 16 and the push rod anti-rotation limit slot 15 and is inserted into the limit slot 14 of the rotary rod 2, so that the rotary rod 2 can only rotate in the shell 1 and cannot fall out axially along the shell 1. The reset rotary rod pin 26 also prevents the push rod 6 from rotating in the shell 1 and can only slide axially along the shell 1 and can only slide the length of the push rod anti-rotation limit slot 15. The push rod 6 cannot slide axially along the shell 1 and fall out of the shell 1.

[0093] The pressing sleeve 8 is a hollow tube structure, the inner hole of the pressing sleeve 8 is sleeved on the pressing sleeve sliding part 29 of the outer shell 1, and the pressing sleeve 8 is provided with a pin hole penetrating in the radial direction.

[0094] The connecting pin 25 passes through the pressing sleeve pin hole 11 on the pressing sleeve 8, the vertically arranged connecting pin 25 slide groove 12 on the outer shell 1 and the release rod pin hole 13 on the release rod 3, so that the pressing sleeve 8 can only slide axially on the outer shell 1 and can only slide the length of the connecting pin 25 slide groove 12. The pressing sleeve 8 is restricted by the connecting pin 25 and cannot fall out of the outer shell 1.

[0095] How to use the microneedle patch applicator:

[0096] The operator uses tweezers to take out the microneedle patch 27, removes the adhesive protective film on the back of the microneedle patch 27, sticks the microneedle patch 27 to the end face of the push rod 6 of the microneedle patch applicator, rotates the rotating rod 2 of the microneedle patch applicator, and the spring pin 9 extending from the rotating rod 2 clamps the reset slide groove 10 of the push rod 6, driving the push rod 6 to retract, so that the push rod 6 retracts into the pressing sleeve 8 of the microneedle patch applicator. When administering medicine to the recipient, the operator holds the shell 1 of the microneedle patch applicator and makes the end face of the pressing sleeve 8 of the microneedle patch applicator fit the skin surface of the recipient. The operator holds the microneedle patch applicator and presses it against the skin side of the recipient. The pressing sleeve 8 drives the release rod 3 to move toward the rotating rod 2 through the connecting pin 25. The spring pin 9 approaches the axis of the rotating rod 2 under the action of the spring sheet 17 and disengages from the reset slide groove 10 of the push rod 6. Then the limiting effect of the spring pin 9 on the push rod 6 is released, and the push rod 6 pops out forward under the action of the compression spring 7, driving the microneedle patch 27 on the end face of the push rod 6 to impact the skin surface of the recipient. The microneedle patch 27 penetrates the stratum corneum of the recipient's skin, and the microneedle patch 27 fits on the skin surface of the recipient.

[0097] The present invention releases the elastic potential energy of the compression spring 7 to ensure that the microneedle patch 27 penetrates and adheres to the surface of human skin with consistent force;

[0098] The present invention uses the sliding groove structure of the rotating rod 2 to make the push rod 6 reset operation simple and quick;

[0099] The present invention makes the drug administration operation of the microneedle patch 27 simple and convenient by pressing the slider structure of the sleeve 8.

[0100] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions within the technical scope disclosed by the present invention should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A microneedle patch applicator, characterized in that: include: Housing (1); A reset rotary rod assembly comprises a rotary rod (2), a release rod (3) and a release rod reset spring (5); the rotary rod (2) extends from the top of the housing (1) into the inner hole thereof, a rotary rod hole (4) is provided at the bottom of the rotary rod (2), and the release rod (3) and the release rod reset spring (5) are both installed in the rotary rod hole (4); A push rod (6) and a compression spring (7) are both installed in the inner hole of the housing (1); the rotary rod (2) is inserted into the push rod (6), and the bottom of the push rod (6) is used to adhere the microneedle patch (27); A pressing sleeve (8) is movably mounted on the bottom of the housing (1); in: A spring pin (9) is installed on the rotary rod (2), a reset slide groove (10) is provided on the push rod (6), one end of the spring pin (9) contacts the outer column wall of the release rod (3), and the other end extends into the reset slide groove (10); The pressing sleeve (8) is provided with a pressing sleeve pin hole (11), the housing (1) is provided with a vertically arranged connecting pin sliding groove (12), the release rod (3) is provided with a release rod pin hole (13), and the connecting pin (25) passes through the pressing sleeve pin hole (11) and the connecting pin sliding groove (12) and is then inserted into the release rod pin hole (13).

2. The microneedle patch applicator according to claim 1, characterized in that: The rotating rod (2) is provided with a limiting groove (14); The push rod (6) is provided with a vertically arranged push rod anti-rotation limiting sliding groove (15); The housing (1) is provided with a housing pin hole (16); The rotating rod clamping pin (26) passes through the housing pin hole (16) and the push rod anti-rotation limiting sliding groove (15) and is then inserted into the limiting groove (14).

3. The microneedle patch applicator according to claim 2, characterized in that: The two ends of the spring pin (9) are respectively connected to the release rod (3) and the push rod (6) through spring sheets (17).

4. The microneedle patch applicator according to claim 3, characterized in that: A spring pin mounting hole (19) communicating with the rotary rod hole (4) is provided on the side wall of the rotary rod (2); A spring pin fixing block (18) is installed on the spring pin installation hole (19); The spring pin (9) is mounted on a spring pin fixing block (18).

5. The microneedle patch applicator according to claim 4, characterized in that: The release rod (3) is provided with an annular diameter-changing groove (24); One end of the spring pin (9) is always in contact with the diameter-changing groove (24) under the action of the spring sheet (17).

6. The microneedle patch applicator according to claim 5, characterized in that: The inner hole of the outer shell (1) comprises a small shallow hole section (20) and a large deep hole section (21) arranged in sequence from top to bottom; The rotary rod (2) passes through the small shallow hole section (20) and then extends into the large deep hole section (21).

7. The microneedle patch applicator according to claim 6, characterized in that: A shell step (22) is formed between the small shallow hole section (20) and the large deep hole section (21); One end of the compression spring (7) is connected to the housing step (22), and the other end is connected to the push rod (6); The rotary rod (2) passes through the compression spring (7).

8. The microneedle patch applicator according to claim 7, characterized in that: A rotating rod head (23) is arranged on the top of the rotating rod (2); The diameter of the rotary rod head (23) is larger than the diameter of the small shallow hole section (20).

9. The microneedle patch applicator according to claim 8, characterized in that: The resetting chute (10) comprises a spiral section (30) and a vertical section (31); The top of the spiral section (30) is connected to the top of the vertical section (31); The outer surface of the housing (1) is provided with a gripping portion (28) and a pressing sleeve sliding portion (29) in sequence from top to bottom; The pressing sleeve (8) is sleeved on the pressing sleeve sliding part (29).

10. A method for administering medicine using a microneedle patch drug delivery device, wherein the drug delivery device is the microneedle patch drug delivery device according to any one of claims 1 to 9, characterized in that: The following steps are involved: The microneedle patch (27) is pasted on the end surface of the push rod (6) of the microneedle patch applicator, and the rotating rod (2) of the microneedle patch applicator is rotated, so that the spring pin (9) extending from the rotating rod (2) is stuck in the reset slide groove (10) of the push rod (6), driving the push rod (6) to retract, so that the push rod (6) is retracted into the pressing sleeve (8) of the microneedle patch applicator; When administering the medicine to a recipient, the end face of the pressing sleeve (8) is pressed against the skin surface of the recipient, and the pressing sleeve (8) drives the release rod (3) to move toward the side of the rotating rod (2) through the connecting pin (25). Under the action of the spring sheet (17), the spring pin (9) approaches the axis of the rotating rod (2) and disengages from the reset slide groove (10) of the push rod (6), whereupon the limiting effect of the spring pin (9) on the push rod (6) is released, and the push rod (6) pops out forward under the action of the compression spring (7), driving the microneedle patch (27) on the end face of the push rod (6) to impact the skin surface of the recipient.

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