Ultrasonic irradiation experiment system and method capable of intelligently adjusting ultrasonic heat effect

Abstract

The invention discloses an ultrasonic irradiation experiment system and method capable of intelligently adjusting the ultrasonic heat effect. The system comprises a constant-temperature degassing water bath kettle, an animal fixing platform, an ultrasonic irradiation system, an optical fiber temperature monitoring system and a signal processing system. High-sensitivity and minimally-invasive temperature measurement is achieved through the optical fiber temperature sensor, accurate temperature data of deep tissue can be obtained in real time, and meanwhile the optical fiber temperature sensor has the advantages of being high in sensitivity, uncharged, small in size, free of interference of an electromagnetic field or ultrasonic waves, high in stability and the like. By combining the integrated design of the fixing device, the stability of the positions of the ultrasonic probe and the mouse is ensured, and personal errors are reduced. The integration of the caudal vein injection device and the anesthesia device further improves the operation convenience and safety of the experiment. Most importantly, according to the system, a computer is used for collecting temperature change signals and controlling ultrasonic output power, a closed-loop adjusting mechanism is formed, and accurate control over treatment parameters is achieved.

Description

Technical Field

[0001] The invention relates to the technical field of ultrasonic irradiation equipment, and in particular to an ultrasonic irradiation experiment system and method capable of intelligently regulating ultrasonic thermal effects. Background Art

[0002] As ultrasound is increasingly used in the medical field, in addition to traditional diagnostics, the research and application of ultrasound as a medical treatment method is also increasing. As a non-invasive technology, ultrasound can be used to irradiate different depths of the body from outside the body, and has the advantage of being controllable in time and space. Therefore, it has been widely used in cancer treatment, drug delivery, tissue rehabilitation and other treatment fields, and related basic research has also increased on a large scale.

[0003] The therapeutic effect of ultrasound is related to the biological effects produced during the propagation of ultrasound, the most important of which is the thermal effect of ultrasound, that is, the energy deposition in the tissue caused by ultrasonic vibration, resulting in a local temperature increase. Since the occurrence of thermal effects, as well as the duration and spatial range of their occurrence, are closely related to the dose of ultrasound, there are large differences in the thermal effects produced under different ultrasound settings. It is usually necessary to closely monitor the temperature changes caused by ultrasound to ensure the actual effect of ultrasound therapy. In the basic research of ultrasound therapy, in order to screen the best treatment plan and ensure the safety and effectiveness of the treatment, it is usually necessary to conduct systematic dose experiments with multiple parameters to detect temperature changes under different experimental conditions and the tissue biological effects caused by them.

[0004] In some treatment scenarios, temperature control is particularly important. For example, in treatments aimed at tumor ablation, the local tissue temperature needs to reach about 60°C to achieve effective tissue ablation and achieve therapeutic effects. In some drug and gene delivery studies, it is necessary to avoid thermal effects as much as possible to reduce interference with the drug delivery system. This shows that in ultrasound therapy experiments, effective temperature monitoring plays a vital role in the development of treatment.

[0005] In previous ultrasound therapy experiments, temperature monitoring usually only relies on external independent systems, such as thermocouples, infrared thermometers, etc., which have two major problems: First, the measurement consistency is poor. The relative position of the external temperature measuring instrument and the animal or tissue is easy to shift in multiple measurements, and in multiple experiments, it needs to be repeatedly dismantled and installed, so the measurement consistency is poor, which reduces the reliability of the treatment effect; Second, there is a lack of real-time data feedback. The temperature data of the external temperature measuring equipment can usually only be obtained through the display reading of the equipment, and it is impossible to perform intelligent parameter adjustment in the ultrasound irradiation system according to the real-time temperature changes, which affects the real-time and accuracy of the treatment.

[0006] The current technical difficulties lie in the human errors and system separation problems during the experiment. Existing ultrasound experiments mostly use independent fixtures and temperature monitoring equipment. This non-integrated design may lead to inconsistencies in ultrasound probe positioning and temperature monitoring, making it difficult to ensure the accuracy of the experiment. In addition, commonly used temperature monitoring methods such as thermocouples and infrared temperature measurement have limitations: electronic sensors such as thermocouples are easily interfered by ultrasound, and metal components will also affect the original distribution of ultrasound; infrared temperature measurement can only measure surface temperature and cannot reflect the thermal effects of deep tissues. More importantly, the real-time linkage adjustment of ultrasound power and temperature has not yet been effectively solved, which can easily lead to uncertainty in treatment.

[0007] Therefore, there is a need for a method and system that can perform real-time temperature monitoring and integrate with an ultrasound therapy system. Summary of the invention

[0008] In view of this, an object of the present invention is to provide an ultrasonic irradiation experimental system capable of intelligently adjusting ultrasonic thermal effects, wherein the system utilizes an embedded temperature monitoring function to adjust the ultrasonic emission signal of the ultrasonic irradiation target area in real time.

[0009] In order to achieve the above object, the present invention provides the following technical solutions: The ultrasonic irradiation experimental system provided by the present invention can perform intelligent regulation of ultrasonic thermal effect, including a constant temperature degassing water bath, an animal fixing platform, an ultrasonic irradiation system, an optical fiber temperature monitoring system, and a signal processing system; The main body cavity of the constant temperature degassing water bath is used to fix the ultrasonic auxiliary system; The upper part of the constant temperature degassing water bath is used to set a fixed platform, and the fixed platform is used to fix the experimental target object; The ultrasonic irradiation system is used to transmit ultrasonic signals to the ultrasonic irradiation target area of ​​the experimental target object; The optical fiber temperature monitoring system is used to monitor the temperature signal of the ultrasonic irradiation target area of ​​the experimental target object and send the temperature signal to the signal processing system; The signal processing system is used to analyze and process the temperature signal to obtain a judgment result, and to control the emission state of the ultrasonic signal of the ultrasonic irradiation system according to the judgment result.

[0010] Furthermore, the signal processing system controls the emission state of the ultrasonic signal of the ultrasonic irradiation system according to the judgment result, and the specific process is as follows: The temperature change value is calculated based on the temperature signal of the monitored target area. If the temperature change value is greater than the preset threshold, an alarm is issued and the ultrasonic output signal is adjusted; if not, the target area temperature signal is returned to be monitored.

[0011] Furthermore, the animal fixing platform includes an animal stabilizing platform, an animal tail fixing device, an animal limb fixing device, and an animal trunk fixing device; The animal stabilizing platform is used to support the animal during ultrasound irradiation; The animal tail fixing device is used to fix the animal tail and the tail vein drug injection auxiliary device during ultrasonic irradiation; The animal limb fixation device is used to fix the limbs during ultrasound irradiation; The animal trunk fixing device is used to fix the trunk during ultrasound irradiation.

[0012] Furthermore, the animal fixing platform also includes a tail vein drug injection auxiliary device, which is used to heat and illuminate the animal's tail when the animal is subjected to ultrasonic irradiation.

[0013] Further, it also includes a gas anesthesia system and a gas anesthesia mask; The gas anesthesia system is used to provide a sedative and analgesic experimental environment for experimental animals during ultrasonic irradiation of animals; The gas anesthesia mask is used to deliver gas anesthetic into the body of the experimental animal during ultrasonic irradiation of the animal.

[0014] Further, the ultrasonic irradiation system includes an ultrasonic transducer fixing device, an ultrasonic transducer, and an ultrasonic irradiation area calibration hole; The ultrasonic transducer fixing device is used to fix the ultrasonic transducer, and the height of the transducer can be adjusted according to the specific usage scenario; The ultrasonic transducer, when used for ultrasonic irradiation of mice, converts input electrical signals into acoustic signals, thereby generating ultrasonic energy; The ultrasonic irradiation area calibration hole is used to determine the ultrasonic irradiation effective area according to the ultrasonic irradiation area calibration hole; Further, the optical fiber temperature monitoring system includes an optical fiber temperature sensor fixing device and an optical fiber temperature sensor; The optical fiber temperature sensor fixing device is used to fix the relative position of the optical fiber temperature sensor and the calibration hole of the ultrasonic irradiation area when the mouse is ultrasonically irradiated; The optical fiber temperature sensor is used to collect temperature information of the ultrasonic irradiation area when the mouse is ultrasonically irradiated; The front end of the optical fiber temperature sensor needs to reach the center point of the calibration hole in the ultrasonic irradiation area so that the front end of the optical fiber temperature sensor fits the ultrasonic irradiation target area.

[0015] The ultrasonic irradiation experiment method provided by the present invention using the ultrasonic irradiation experiment system capable of intelligently adjusting the ultrasonic thermal effect is specifically carried out in the following steps: S1: Build an ultrasound irradiation experimental system, fix the experimental animal, align the animal's tumor site with the ultrasound irradiation area calibration hole, and place the optical fiber temperature sensor close to the ultrasound irradiation target area; S2: Start the system, collect temperature and determine the temperature change value; S3: When the temperature is within the predetermined range, the ultrasonic output is maintained; S4: When the temperature exceeds a predetermined range, adjusting the ultrasonic output; S5: The computer draws the temperature change curve.

[0016] Further, the temperature is set within the predetermined range in the following manner: Current temperature T1-initial temperature T0>preset threshold; the preset threshold is 1-2°C.

[0017] The beneficial effects of the present invention are: The present invention provides an ultrasonic irradiation experimental system that can perform intelligent regulation of ultrasonic thermal effects. The system realizes high-sensitivity, minimally invasive temperature measurement through an optical fiber temperature sensor, and can obtain accurate temperature data of deep tissues in real time. At the same time, the optical fiber temperature sensor has the advantages of high sensitivity, no electricity, small size, no interference from electromagnetic fields or ultrasonic waves, and high stability. Combined with the integrated design of the fixing device, the stability of the position of the ultrasonic probe and the mouse is ensured, and human errors are reduced. The integration of the tail vein injection device and the anesthesia device further improves the operational convenience and safety of the experiment. Most importantly, the system uses a computer to collect temperature change signals and control the ultrasonic output power to form a closed-loop regulation mechanism, which realizes precise control of treatment parameters.

[0018] The advantages of this system include: 1. It improves the accuracy and sensitivity of temperature monitoring; 2. It reduces human errors and operational complexity in experiments through system integration; 3. It realizes the linkage control of ultrasound output power and temperature changes, and enhances the repeatability and reliability of experimental data; 4. It improves the safety and research efficiency of mouse treatment. This system provides a more efficient and accurate platform for mouse ultrasound treatment research.

[0019] This system integrates fiber optic temperature sensors, mice, and ultrasound probe fixtures to achieve accurate real-time monitoring and control of temperature during the experiment. Through a closed-loop regulation mechanism, the temperature monitoring signal is linked to the ultrasound output power, greatly improving the accuracy and repeatability of the experiment. The integrated design simplifies experimental operations, reduces human errors, and improves the safety of mouse treatment and research efficiency.

[0020] Other advantages, objectives and features of the present invention will be described in the following description to some extent, and to some extent, will be obvious to those skilled in the art based on the following examination and study, or can be taught from the practice of the present invention. The objectives and other advantages of the present invention can be realized and obtained through the following description. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to make the purpose, technical solution and beneficial effects of the present invention clearer, the present invention provides the following drawings for explanation.

[0022] Figure 1 Schematic diagram of the system structure.

[0023] Figure 2 This is the structural diagram of the intelligent and adjustable ultrasonic irradiation experiment system.

[0024] Figure 3 A stereoscopic diagram of an intelligent and adjustable ultrasonic irradiation experiment system.

[0025] Figure 4 It is a device for calibrating the ultrasonic irradiation area.

[0026] Figure 5 Schematic diagram of the data flow relationship of this system.

[0027] Figure 6 This is the control logic diagram of the temperature detection feedback and regulation system.

[0028] Figure 7 Temperature monitoring under different ultrasound parameters.

[0029] In the figure, there are a constant temperature water bath 1, an ultrasonic transducer fixture 2, an ultrasonic transducer 3, an animal tail fixture 4, an animal limb fixture 5, an animal trunk fixture 6, an optical fiber temperature sensor fixture 7, a gas anesthesia mask 8, an optical fiber temperature sensor 9, an animal stabilizing platform 10, an ultrasonic irradiation area calibration hole 11, an optical fiber temperature detection system 12, a signal processing system 13, and an ultrasonic irradiation system 14. DETAILED DESCRIPTION

[0030] The present invention is further described below in conjunction with the accompanying drawings and specific embodiments so that those skilled in the art can better understand the present invention and implement it, but the embodiments are not intended to limit the present invention.

[0031] Example 1 like Figure 1 As shown, the ultrasonic irradiation experiment system provided in this embodiment can perform intelligent regulation of ultrasonic thermal effect, and the ultrasonic irradiation experiment system with embedded temperature real-time monitoring function includes a constant temperature degassing water bath, an animal fixing platform, an ultrasonic irradiation system, an optical fiber temperature monitoring system, and a signal processing system; The main body cavity of the constant temperature degassing water bath is used to fix the ultrasonic auxiliary system; The upper part of the constant temperature degassing water bath is used to set a fixed platform, and the fixed platform is used to fix the experimental target animal; The ultrasonic irradiation system is used to transmit ultrasonic signals to the ultrasonic irradiation target area of ​​the experimental target object; The optical fiber temperature monitoring system is used to monitor the temperature signal of the ultrasonic irradiation target area of ​​the experimental target object and send the temperature signal to the signal processing system; The signal processing system is used to analyze and process the temperature signal to obtain a judgment result, and control the emission state of the ultrasonic signal of the ultrasonic irradiation system according to the judgment result; In the signal processing system provided in this embodiment, the emission state of the ultrasonic signal of the ultrasonic irradiation system is controlled according to the judgment result, and the specific process is as follows: Calculate the temperature change value according to the temperature signal of the monitoring target area, and check whether the temperature change value is greater than a preset threshold value. If yes, issue an alarm and adjust the ultrasonic output signal; if no, return to continue monitoring the temperature signal of the target area; In this embodiment, if the current temperature is higher than the initial temperature by 1.5°C, the computer alarm is triggered and the computer immediately adjusts the ultrasonic output power. Alarm triggering conditions: Current temperature T1-initial temperature T0>preset threshold; The preset threshold is 1-2°C; in this embodiment, the preset threshold is 1.5°C; like Figure 2 and Figure 3 As shown, the animal fixing platform in this embodiment includes an animal stabilizing platform, an animal tail fixing device, an animal limb fixing device, and an animal trunk fixing device; The animal stabilization platform is used to bear the weight of the animal during ultrasonic irradiation of the animal; The animal tail fixing device is used to fix the animal's tail during animal ultrasonic irradiation, and to assist in heating and irradiation during tail vein drug injection; The animal limb fixing device is used to fix the animal's limbs during ultrasonic irradiation of the animal; The animal trunk fixing device is used to fix the animal trunk during ultrasonic irradiation of the animal; The animals used in this example were mice; The ultrasonic irradiation experimental system provided in this embodiment also includes a tail vein drug injection auxiliary device, The tail vein drug injection auxiliary device is used for auxiliary functions such as tail heating and illumination during ultrasound irradiation of mice; the tail heating function is used to dilate the tail vein blood vessels of mice to facilitate drug injection. The illumination function is to observe the position and state of the target blood vessels more clearly and intuitively during drug injection, which is convenient for drug injection.

[0032] The ultrasonic irradiation experimental system provided in this embodiment also includes a gas anesthesia system and a gas anesthesia mask; The gas anesthesia system, when used for animal ultrasound irradiation, provides a sedative and analgesic experimental environment for experimental animals, which also complies with the relevant requirements of experimental animal ethics; The gas anesthesia mask is used to accurately and safely deliver gas anesthetics (such as isoflurane) into the body of experimental animals during ultrasonic irradiation of animals. The constant temperature degassed water bath in this embodiment is used to act as an ultrasonic propagation medium during ultrasonic irradiation of mice. Due to the particularity of ultrasonic therapy, ultrasonic waves will attenuate ultrasonic energy due to the different media during the propagation process. Water, as a good sound propagation medium, is very important in this design. At the same time, since there is a certain amount of tiny air bubbles in conventional water, it will cause changes in the distribution of ultrasonic energy or cause the attenuation of ultrasonic energy, so this design requires degassing of water. At the same time, when used for ultrasonic irradiation of mice, the ambient temperature of the ultrasonic target area is controlled. When ultrasonic irradiation of mice, too high or too low ambient temperature is not conducive to the development of the experiment, so this design ensures the constant experimental temperature.

[0033] like Figure 4 As shown, the ultrasonic irradiation system in this embodiment includes an ultrasonic transducer fixing device, an ultrasonic transducer, and an ultrasonic irradiation area calibration hole; The ultrasonic transducer fixing device is used to fix the ultrasonic transducer, and the height of the transducer can be adjusted according to the specific usage scenario; The ultrasonic transducer, when used for ultrasonic irradiation of mice, converts input electrical signals into acoustic signals, thereby generating ultrasonic energy; The ultrasonic irradiation area calibration hole is used to confirm the ultrasonic irradiation target area during ultrasonic irradiation of mice, that is, the area within the ultrasonic irradiation area calibration hole is the ultrasonic irradiation effective area.

[0034] The front end of the fiber optic temperature sensor needs to reach the center point of the calibration hole in the ultrasonic irradiation area, and in order to meet different application scenarios (such as tumors of different diameters), the relative position of the fiber optic temperature sensor and the calibration hole in the ultrasonic irradiation area can be adjusted according to the specific usage scenario, so as to achieve the purpose of the front end of the fiber optic temperature sensor closely fitting the ultrasonic irradiation target area; The optical fiber temperature monitoring system in this embodiment includes an optical fiber temperature sensor fixing device and an optical fiber temperature sensor, and is used to monitor the temperature of the ultrasonic irradiation area when the mouse is ultrasonically irradiated.

[0035] The optical fiber temperature sensor fixing device is used to fix the relative position of the optical fiber temperature sensor and the calibration hole of the ultrasonic irradiation area when the mouse is ultrasonically irradiated; The optical fiber temperature sensor is used to collect temperature information of the ultrasonic irradiation area when the mouse is ultrasonically irradiated.

[0036] The gas anesthesia system in this embodiment is used for ultrasound irradiation of mice to provide a sedative and analgesic experimental environment for experimental animals, which also complies with the relevant requirements of experimental animal ethics; This embodiment also includes a gas anesthesia mask, which is used for accurately and safely delivering gas anesthetics (such as isoflurane) into the body of the experimental animal during ultrasound irradiation of mice; The signal processing system of this embodiment adopts a computer system; a PID controller is provided in the signal processing system, and the PID controller is used to analyze and process the temperature signal fed back by the optical fiber temperature measurement system, and calculate the control adjustment signal of the ultrasonic transducer system according to the temperature difference; the PID controller is operated in the following manner: The system provided in this embodiment integrates and redevelops the temperature monitoring system with the ultrasonic treatment system through an embedded real-time temperature monitoring system, thereby realizing real-time regulation of ultrasonic parameters based on temperature feedback. At the same time, through the matching animal / tissue biological sample fixation and transducer positioning system, the consistency of spatial positioning of various components in ultrasonic treatment can be effectively guaranteed, thereby greatly improving the accuracy and repeatability of ultrasonic treatment experiments.

[0037] This system provides a complete and reliable platform for ultrasound therapy experiments and related basic research, and enables real-time and accurate monitoring and regulation of thermal effects in ultrasound experiments, making it a useful tool for basic research in ultrasound therapy.

[0038] Example 2 like Figure 5 As shown, the ultrasonic irradiation experimental method provided in this embodiment that can perform intelligent regulation of ultrasonic thermal effect is specifically carried out in the following steps: S1: Build the ultrasonic irradiation experimental system; realize the device construction; S2: Collect temperature and determine temperature change value; S3: When the temperature is within the predetermined range, the ultrasonic output is maintained; S4: When the temperature exceeds a predetermined range, adjusting the ultrasonic output; S5: Computer draws temperature change curve; Take mice as an example to illustrate the experimental process: At the beginning of the mouse ultrasound treatment, the mouse is first pre-anesthetized, and then placed on the mouse stable platform 10, and the mouse tail, limbs and trunk are fixed using the mouse tail fixing device, mouse limb fixing device, and mouse trunk fixing device, the mouse tumor site is aligned with the calibration hole of the ultrasound irradiation area, and the optical fiber temperature sensor is placed close to the ultrasound irradiation target area. Finally, the mouse nose is placed in a gas anesthesia mask.

[0039] After fixing the mouse's position, adjust the height of the ultrasonic transducer fixture according to the transducer's focal length. Then turn on the fiber optic temperature monitoring system and confirm that the signal processing system (computer) records the temperature changes in real time. Turn on the ultrasonic irradiation system; If the temperature monitoring system detects that the current temperature change is greater than the initial temperature by 1.5°C, the signal processing system (computer) will issue an alarm and adjust the ultrasonic output; otherwise, it will remain unchanged.

[0040] like Figure 6 As shown, Figure 6 This is a control logic diagram of the temperature detection feedback and regulation system. In terms of the optical fiber temperature measurement system, a PID controller is provided in the signal processing system. The PID controller is used to analyze and process the temperature signal fed back by the optical fiber temperature measurement system, and calculate the control adjustment signal of the ultrasonic transducer system according to the temperature difference; the PID controller is operated in the following manner: First, the pulse modulation module generates appropriate electrical pulses to drive the semiconductor laser diode to emit the required laser pulses. After the laser pulses are coupled by the coupler, they are transmitted to the ultrasound target area through the Y-type splitter. Subsequently, the optical signal enters the photodetector and is converted into an electrical signal, which is amplified by the amplifier circuit to meet the analog-to-digital conversion (A / D) sampling requirements. The A / D converted signal is transmitted to the PID controller, which outputs the control signal according to the following formula: ; Where, u(t): controller output; e(t): real-time error; Kp, Ki, Kd: proportional, integral, and differential gains, respectively; In different application scenarios, the specific values ​​of Kp, Ki, and Kd are different, corresponding to different temperature ranges; The temperature is limited within the specified range, and the temperature signal is displayed on the display in the form of a waveform. If the temperature exceeds the preset threshold, the system will trigger an alarm. In the ultrasonic transducer system, the pulse modulation module is commanded by the central processor to generate appropriate electrical pulses. The electrical signal is amplified by the amplifier circuit, thereby triggering the piezoelectric transducer to generate an acoustic signal.

[0041] The calculation unit for temperature feedback in this embodiment, namely the PID controller, adjusts the ultrasonic output from three aspects: namely, the proportional term (P): proportional to the error, quickly responding to the temperature difference; the integral term (I): accumulating the error and eliminating the steady-state error; the differential term (D): predicting the error change trend and improving the response stability; in this way, the ultrasonic regulation of temperature is more accurate.

[0042] Finally, the temperature data is collected by computer and the temperature change curve is drawn.

[0043] like Figure 7 As shown, Figure 7 For temperature monitoring under different ultrasound parameters: three experimental groups were set up, and the ultrasound parameter settings were ultrasound sound power 1W, ultrasound duty cycle 2%, ultrasound treatment time 30S; 1W, 20%, 90S; 1W, 20%, 90S; by detecting the ultrasound target area temperature within 20 minutes, the above chart was statistically obtained. It can be seen from the figure that the ultrasound target area temperature of the three experimental groups did not exceed the "+1.5℃" alarm line within 20 minutes.

[0044] This embodiment also includes a drug injection process. When the ultrasonic irradiation system is turned on, if tail vein drug injection is required, the drug injection can be performed through the mouse tail fixing device.

[0045] The above-described embodiments are only preferred embodiments for fully illustrating the present invention, and the protection scope of the present invention is not limited thereto. Equivalent substitutions or changes made by those skilled in the art based on the present invention are within the protection scope of the present invention. The protection scope of the present invention shall be subject to the claims.

Claims

1. Ultrasonic irradiation experimental system capable of intelligently regulating ultrasonic thermal effect, characterized in that: It includes a constant temperature degassing water bath, an animal fixing platform, an ultrasonic irradiation system, an optical fiber temperature monitoring system and a signal processing system; The main body cavity of the constant temperature degassing water bath is used to fix the ultrasonic auxiliary system; The upper part of the constant temperature degassing water bath is used to set a fixed platform, and the fixed platform is used to fix the experimental target object; The ultrasonic irradiation system is used to transmit ultrasonic signals to the ultrasonic irradiation target area of ​​the experimental target object; The optical fiber temperature monitoring system is used to monitor the temperature signal of the ultrasonic irradiation target area of ​​the experimental target object and send the temperature signal to the signal processing system; The signal processing system is used to analyze and process the temperature signal to obtain a judgment result, and to control the emission state of the ultrasonic signal of the ultrasonic irradiation system according to the judgment result.

2. The ultrasonic irradiation experimental system capable of intelligently adjusting ultrasonic thermal effect as claimed in claim 1, characterized in that: The signal processing system controls the emission state of the ultrasonic signal of the ultrasonic irradiation system according to the judgment result, and the specific process is as follows: The temperature change value is calculated based on the temperature signal of the monitored target area. If the temperature change value is greater than the preset threshold, an alarm is issued and the ultrasonic output signal is adjusted; if not, the target area temperature signal is returned to be monitored.

3. The ultrasonic irradiation experimental system capable of intelligently adjusting ultrasonic thermal effect as claimed in claim 1, characterized in that: The animal fixing platform comprises an animal stabilizing platform, an animal tail fixing device, an animal limb fixing device and an animal trunk fixing device; The animal stabilizing platform is used to support the animal during ultrasound irradiation; The animal tail fixing device is used to fix the animal tail and the tail vein drug injection auxiliary device during ultrasonic irradiation; The animal limb fixation device is used to fix the limbs during ultrasound irradiation; The animal trunk fixing device is used to fix the trunk during ultrasound irradiation.

4. The ultrasonic irradiation experimental system capable of intelligently adjusting ultrasonic thermal effect as claimed in claim 3, characterized in that: The animal fixing platform also includes a tail vein drug injection auxiliary device, which is used to heat and illuminate the tail of the animal when performing ultrasonic irradiation on the animal.

5. The ultrasonic irradiation experimental system capable of intelligently adjusting ultrasonic thermal effect as claimed in claim 1, characterized in that: It also includes a gas anesthesia system and a gas anesthesia mask; The gas anesthesia system is used to provide a sedative and analgesic experimental environment for experimental animals during ultrasonic irradiation of animals; The gas anesthesia mask is used to deliver gas anesthetic into the body of the experimental animal during ultrasonic irradiation of the animal.

6. The ultrasonic irradiation experimental system capable of intelligently adjusting ultrasonic thermal effect as claimed in claim 1, characterized in that: The ultrasonic irradiation system comprises an ultrasonic transducer fixing device, an ultrasonic transducer, and an ultrasonic irradiation area calibration hole; The ultrasonic transducer fixing device is used to fix the ultrasonic transducer, and the height of the transducer can be adjusted according to the specific usage scenario; The ultrasonic transducer, when used for ultrasonic irradiation of mice, converts input electrical signals into acoustic signals, thereby generating ultrasonic energy; The ultrasonic irradiation area calibration hole is used to determine the ultrasonic irradiation effective area according to the ultrasonic irradiation area calibration hole.

7. The ultrasonic irradiation experimental system capable of intelligently adjusting ultrasonic thermal effect as claimed in claim 1, characterized in that: The optical fiber temperature monitoring system comprises an optical fiber temperature sensor fixing device and an optical fiber temperature sensor; The optical fiber temperature sensor fixing device is used to fix the relative position of the optical fiber temperature sensor and the calibration hole of the ultrasonic irradiation area when the mouse is ultrasonically irradiated; The optical fiber temperature sensor is used to collect temperature information of the ultrasonic irradiation area when the mouse is ultrasonically irradiated; The front end of the optical fiber temperature sensor needs to reach the center point of the calibration hole in the ultrasonic irradiation area so that the front end of the optical fiber temperature sensor fits the ultrasonic irradiation target area.

8. The ultrasonic irradiation experimental system capable of intelligently adjusting ultrasonic thermal effect as claimed in claim 1, characterized in that: The signal processing system is provided with a PID controller, which is used to analyze and process the temperature signal fed back by the optical fiber temperature measurement system, and calculate the control adjustment signal of the ultrasonic transducer system according to the temperature difference; the PID controller is operated in the following manner: The pulse modulation module generates appropriate electrical pulses to drive the semiconductor laser diode to emit the required laser pulses. After the laser pulses are coupled by the coupler, they are transmitted to the ultrasound target area through the Y-type splitter. Subsequently, the optical signal enters the photodetector and is converted into an electrical signal. The electrical signal is amplified by the amplifier circuit to meet the sampling requirements of the analog-to-digital conversion A / D. After the analog-to-digital conversion A / D is completed, the signal is transmitted to the PID controller, and the PID controller outputs the control signal according to the following formula: ； Where, u(t): controller output; e(t): real-time error; Kp, Ki, Kd: proportional, integral, and differential gains, respectively.

9. An ultrasonic irradiation experiment method is performed using the ultrasonic irradiation experiment system capable of intelligently adjusting ultrasonic thermal effect as described in any one of claims 1 to 8, characterized in that: Follow these steps: S1: Build an ultrasound irradiation experimental system, fix the experimental animal, align the animal's tumor site with the ultrasound irradiation area calibration hole, and place the optical fiber temperature sensor close to the ultrasound irradiation target area; S2: Start the system, collect temperature and determine the temperature change value; S3: When the temperature is within the predetermined range, the ultrasonic output is maintained; S4: When the temperature exceeds a predetermined range, adjusting the ultrasonic output; S5: The computer draws the temperature change curve.

10. The ultrasonic irradiation experimental method capable of intelligently adjusting ultrasonic thermal effect according to claim 9, characterized in that: The temperature is set within the predetermined range in the following manner: Current temperature T1-initial temperature T0>preset threshold; the preset threshold is 1-2°C.

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