Monitoring method for neuromuscular disease biological medicine
By extracting blood and urine samples from neuromuscular patients at different time periods, monitoring specific parameters, analyzing and comparing parameter changes in different time periods, the problem of difficult to determine the optimal time for taking biomedical medicine in neuromuscular is solved, improving the treatment effect and visually displaying the results through image comparison.
Patent Information
- Application Number
- CN202411919105.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-24
- Publication Date
- 2025-04-25
AI Technical Summary
The prior art is difficult to determine the optimal time for taking neuromuscular biomedicine, resulting in unstable therapeutic effects.
By injecting standard concentrations of drugs into the patient and taking blood and urine samples at different time periods, the parameters of serum creatine phosphate kinase (CPK), serum myoglobin (MB), serum pyruvate (PK), and glucose (GLU) and bilirubin (BI L) in urine were monitored, and the parameter changes in different time periods were analyzed and compared to determine the optimal time of taking the drug.
By monitoring and analyzing biomarker parameters at different time periods, it can be determined during which time period the drug achieves the best treatment effect, improve the therapeutic effect of neuromuscular disease, and see the results more intuitively through image comparison.
Smart Images

Figure CN119881291A_ABST
Abstract
Description
Technical Field
[0001] The present invention relates to the field of medicine monitoring methods, in particular to a monitoring method for neuromuscular disease biomedicine. Background Art
[0002] Neuromuscular disease is a group of diseases that involve the nerves and muscles. There are many types of neuromuscular disease. Neuromuscular disease is not a single disease, but a general term for a large group of diseases.
[0003] When treating neuromuscular diseases, drugs are needed. Before using the drugs, the drugs need to be monitored to monitor the patient's recovery. When using the drugs, it is not clear in which time period the drugs will achieve the best therapeutic effect for the patient. If the patient uses the drugs directly, the treatment effect will be unstable. Summary of the invention
[0004] Technical issues solved
[0005] In view of the shortcomings of the prior art, the present invention provides a monitoring method for biomedicine for neuromuscular disease, which solves the problem of unclear optimal time period for taking drugs.
[0006] Technical Solution
[0007] To achieve the above objectives, the present invention is implemented through the following technical solutions: A monitoring method for neuromuscular disease biomedicine, comprising the following steps:
[0008] S1. Inject the drug of standard concentration into the patient and record the injection time;
[0009] S2. Draw blood and urine from the patient;
[0010] S3, dividing the blood and urine into three groups, the three groups are samples extracted in three time periods respectively, and monitoring the parameters of the three groups of samples;
[0011] S4. Compare the three groups of parameters and analyze the monitoring results.
[0012] Preferably, the three groups of samples are blood samples and urine samples, respectively. The parameters that need to be monitored in the blood samples include serum creatine phosphokinase (CPK), serum myoglobin (MB), and serum pyruvase (PK), and the parameters that need to be monitored in the urine samples include glucose (GLU) and bilirubin (BI L).
[0013] Preferably, the normal content ranges of serum creatine phosphokinase (CPK), serum myoglobin (MB), and serum pyruvase (PK) are: serum creatine phosphokinase (CPK) 18-198u / l, serum myoglobin (MB) 8-20μg / l, and serum pyruvase (PK) 84.30u / l.
[0014] Preferably, when analyzing the parameters in S3, the urine sample monitoring judgment formula is Y=a*b, wherein a represents the judgment result of the glucose (GLU) content, and b represents the judgment result of the bilirubin (BI L) content. When the judgment result is monitored as positive, the output result is 0, otherwise it is 1. The data Y output result of 0 indicates that the glucose (GLU) and bilirubin (BI L) in the patient's urine during this time period are positive, which is an abnormal phenomenon, otherwise it is a normal phenomenon.
[0015] Preferably, the parameter comparison in S4 is to make a blood parameter comparison chart and a urine parameter comparison chart for three time periods, and the blood parameter comparison chart is vertically divided into the time axis and horizontally divided into the content of serum creatine phosphokinase (CPK), serum myoglobin (MB), and serum pyruvase (PK), and the urine parameter comparison chart is vertically divided into the time axis and horizontally divided into glucose (GLU) and bilirubin (BI L).
[0016] Preferably, the three time periods are 8:00-9:30 in the morning, 11:30-13:00 in the afternoon, and 18:00-19:30 in the evening, and the blood and urine samples are drawn 1 hour after taking the samples.
[0017] Preferably, the blood and urine samples are placed in test tubes, and the corresponding extraction time period, parameters to be monitored, and names of therapeutic drugs to be taken are labeled on the test tubes.
[0018] Beneficial Effects
[0019] The present invention provides a monitoring method for neuromuscular disease biomedicine. It has the following beneficial effects:
[0020] By sampling blood and urine samples in three time periods, different parameters of the three time periods are monitored to determine the best time to take therapeutic drugs, increase the therapeutic effect of neuromuscular diseases, and analyze them in the form of graphs to see the comparison results more clearly. BRIEF DESCRIPTION OF THE DRAWINGS
[0021] Figure 1 It is a flow chart of the present invention. DETAILED DESCRIPTION
[0022] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0023] Embodiment 1:
[0024] like Figure 1 As shown, an embodiment of the present invention provides a monitoring method for neuromuscular disease biomedicine, comprising the following steps:
[0025] S1. Inject the drug of standard concentration into the patient and record the injection time;
[0026] S2. Draw blood and urine from the patient;
[0027] S3, blood and urine are divided into three groups, the three groups are samples extracted in three time periods, and the parameters of the three groups of samples are monitored. The three groups of samples are blood samples and urine samples. The parameters that need to be monitored in the blood sample are serum creatine phosphokinase (CPK), serum myoglobin (MB), serum pyruvase (PK), and the parameters that need to be monitored in the urine sample are glucose (GLU) and bilirubin (BI L). When the parameters are analyzed in S3, the urine sample monitoring judgment formula is Y=a*b, where a represents the glucose (GLU) content judgment result, and b represents the bilirubin (BIL) content judgment result. When the judgment result is positive, the output result is 0, otherwise it is 1. The data Y output result is 0, which means that the glucose (GLU) and bilirubin (BI L) content of the patient's urine in this time period are positive. L) is positive, which is an abnormal phenomenon, otherwise it is a normal phenomenon. The three time periods are 8:00-9:30 in the morning, 11:30-13:00 in the afternoon, and 18:00-19:30 in the evening. The blood and urine samples are drawn 1 hour after taking the samples. The Y judgment result is 0, which means that the time period is not suitable for taking the medicine, otherwise the medicine can continue to be taken.
[0028] S4. Compare the three groups of parameters and analyze the monitoring results. Compare the parameters in S4, make blood parameter comparison charts and urine parameter comparison charts for the three time periods, and use the blood parameter comparison chart as the time axis vertically and serum creatine phosphokinase (CPK), serum myoglobin (MB), and serum pyruvase (PK) content horizontally. The urine parameter comparison chart has a time axis vertically and glucose (GLU) and bilirubin (BIL) horizontally. Through the comparison chart, it can be clearly seen which time period has a better treatment effect. By setting the normal standard value and comparing it with the monitored parameters, the larger the comparison result, the weaker the treatment effect, and vice versa.
[0029] The normal range of serum creatine phosphokinase (CPK), serum myoglobin (MB), and serum pyruvase (PK) is: serum creatine phosphokinase (CPK) 18u / l, serum myoglobin (MB) 8μg / l, serum pyruvase (PK) 84.30u / l, which is the normal value for males.
[0030] Blood and urine samples are placed in test tubes, and the corresponding extraction time period, parameters to be monitored, and names of therapeutic drugs taken are labeled on the test tubes to facilitate staff to make comparison charts.
[0031] Embodiment 2:
[0032] like Figure 1 As shown, an embodiment of the present invention provides a monitoring method for neuromuscular disease biomedicine, comprising the following steps:
[0033] S1. Inject the drug of standard concentration into the patient and record the injection time;
[0034] S2. Draw blood and urine from the patient;
[0035] S3, blood and urine are divided into three groups, and the three groups are samples extracted in three time periods respectively, and the parameters of the three groups of samples are monitored. The three groups of samples are blood samples and urine samples respectively. The parameters that need to be monitored in the blood sample are serum creatine phosphokinase (CPK), serum myoglobin (MB), serum pyruvase (PK), and the parameters that need to be monitored in the urine sample are glucose (GLU) and bilirubin (BIL). When analyzing the parameters in S3, the urine sample monitoring judgment formula is Y=a*b, where a represents the judgment result of the glucose (GLU) content, and b represents the content of glucose (GLU). It indicates the judgment result of bilirubin (BIL) content. When the judgment result is positive, the output result is 0, otherwise it is 1. The data Y output result is 0, which means that the glucose (GLU) and bilirubin (BIL) in the patient's urine during this period are positive, which is an abnormal phenomenon. Otherwise it is a normal phenomenon. The three time periods are 8:00-9:30 in the morning, 11:30-13:00 in the afternoon, and 18:00-19:30 in the evening. The blood and urine samples are drawn 1 hour after taking the samples. The Y judgment result is 0, which means that the time period is not suitable for taking the medicine, otherwise the medicine can continue to be taken.
[0036] S4. Compare the three groups of parameters and analyze the monitoring results. Compare the parameters in S4, make blood parameter comparison charts and urine parameter comparison charts for the three time periods, and use the blood parameter comparison chart as the time axis vertically and serum creatine phosphokinase (CPK), serum myoglobin (MB), and serum pyruvase (PK) content horizontally. The urine parameter comparison chart has a time axis vertically and glucose (GLU) and bilirubin (BI L) horizontally. Through the comparison chart, it can be clearly seen which time period has a better treatment effect. By setting the normal standard value and comparing it with the monitored parameters, the larger the comparison result, the weaker the treatment effect, and vice versa.
[0037] The normal range of serum creatine phosphokinase (CPK), serum myoglobin (MB), and serum pyruvase (PK) is: serum creatine phosphokinase (CPK) 198u / l, serum myoglobin (MB) 20μg / l, serum pyruvase (PK) 84.30u / l, which is the normal value for males.
[0038] Blood and urine samples are placed in test tubes, and the corresponding extraction time period, parameters to be monitored, and names of therapeutic drugs taken are labeled on the test tubes to facilitate staff to make comparison charts.
[0039] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. A method for monitoring biomedicine for neuromuscular disease, characterized in that: The following steps are involved: S1. Inject the drug of standard concentration into the patient and record the injection time; S2. Draw blood and urine from the patient; S3, dividing the blood and urine into three groups, the three groups are samples extracted in three time periods respectively, and monitoring the parameters of the three groups of samples; S4. Compare the three groups of parameters and analyze the monitoring results.
2. A method for monitoring biomedicine for neuromuscular disease according to claim 1, characterized in that: The three groups of samples are blood samples and urine samples. The parameters that need to be monitored in the blood samples include serum creatine phosphokinase (CPK), serum myoglobin (MB), and serum pyruvase (PK). The parameters that need to be monitored in the urine samples include glucose (GLU) and bilirubin (BIL).
3. A method for monitoring biomedicine for neuromuscular disease according to claim 2, characterized in that: The normal content ranges of serum creatine phosphokinase (CPK), serum myoglobin (MB), and serum pyruvase (PK) are: serum creatine phosphokinase (CPK) 18-198u / l, serum myoglobin (MB) 8-20μg / l, and serum pyruvase (PK) 84.30u / l.
4. A method for monitoring biomedicine for neuromuscular disease according to claim 2, characterized in that: When analyzing the parameters in S3, the urine sample monitoring judgment formula is Y=a*b, wherein a represents the judgment result of the glucose (GLU) content, and b represents the judgment result of the bilirubin (BIL) content. When the judgment result is monitored as positive, the output result is 0, otherwise it is 1. The data Y output result of 0 indicates that the glucose (GLU) and bilirubin (BIL) in the patient's urine during this time period are positive, which is an abnormal phenomenon, otherwise it is a normal phenomenon.
5. A method for monitoring biomedicine for neuromuscular disease according to claim 1, characterized in that: The parameters in S4 are compared to make blood parameter comparison graphs and urine parameter comparison graphs for three time periods, and the blood parameter comparison graph is vertically divided into the time axis and horizontally divided into the contents of serum creatine phosphokinase (CPK), serum myoglobin (MB), and serum pyruvase (PK). The urine parameter comparison graph is vertically divided into the time axis and horizontally divided into glucose (GLU) and bilirubin (BIL).
6. A method for monitoring biomedicine for neuromuscular disease according to claim 1, characterized in that: The three time periods are 8:00-9:30 in the morning, 11:30-13:00 in the afternoon, and 18:00-19:30 in the evening, and blood and urine samples are drawn 1 hour after taking the samples.
7. A method for monitoring biomedicine for neuromuscular disease according to claim 1, characterized in that: The blood and urine samples are placed in test tubes, and the corresponding extraction time period, the parameters to be monitored, and the name of the therapeutic drug to be taken are labeled on the test tubes.