SPF potentiators and sunscreen formulations comprising same

Abstract

There is provided an SPF synergist comprising a functionalized maltodextrin, the functionalized maltodextrin comprising a maltodextrin base polymer functionalized with a-Si (R1) 3 group; wherein each R1 is independently a C1-10 linear or branched saturated alkyl group; wherein the maltodextrin base polymer has a dextrose equivalent (DE) of from 1 to 15; wherein the functionalized maltodextrin has a degree of substitution, DS, of the-Si (R1) 3 group of 1.7 to 3; and wherein the functionalized maltodextrin is free of vinyl carbons. The invention also provides a sunscreen preparation containing the SPF synergist and a method for using the SPF synergist.

Description

[0001] The present invention relates to an SPF enhancer and a sunscreen preparation comprising the SPF enhancer. In particular, the present invention relates to a sunscreen enhancer comprising: functionalized maltodextrin, wherein the functionalized maltodextrin comprises a -Si(R 1 ) 3 A maltodextrin base polymer functionalized with a group; wherein each R 1 Independently C 1-10 A linear or branched saturated alkyl group; wherein the maltodextrin base polymer has a dextrose equivalent DE of 1 to 15; wherein the functionalized maltodextrin has a -Si(R 1 ) 3 The present invention relates to a sunscreen preparation comprising the sunscreen enhancer.

[0002] The damaging effects of sunlight on human skin are well documented. Six percent of the solar energy that reaches the Earth's surface is ultraviolet (UV) radiation with a wavelength of 290nm to 400nm. This radiation consists of two components: (i) low-energy UVA radiation with a wavelength of 320nm to 400nm and (ii) high-energy UVB radiation with a wavelength of 290nm to 320nm. Although the UV portion of solar energy is relatively small, it causes nearly 99% of the side effects of sunlight exposure. For example, high-energy UVB radiation can lead to the development of sunburn, skin aging, and the appearance of skin cancer. For example, low-energy UVA radiation can cause direct tanning and erythema (abnormal redness) of the skin, and contribute to the appearance of skin aging.

[0003] By avoiding direct exposure to sunlight, individuals can avoid the serious effects caused by exposure to UV radiation. However, due to the nature of some people's work, it is challenging for them to avoid such exposure. In addition, some people voluntarily expose their skin to the sun, for example, to get a tan. Therefore, it is important to protect against the harmful effects of the sun.

[0004] Protection from the harmful effects of UV radiation exposure can be provided in the form of two topical formulations containing at least one physical UV blocker or at least one chemical UV absorber or a combination thereof. Physical blockers include active ingredients such as titanium dioxide, zinc oxide, and red petrolatum. Chemical absorbers include active ingredients such as para-aminobenzoic acid (more commonly known as PABA), which is usually transparent when applied and works by absorbing UV radiation, providing selective protection against certain UV bands depending on the absorption spectrum of the active ingredient in the formulation.

[0005] The effectiveness of a given sunscreen formulation is assessed by how well it protects the skin in terms of the sun protection factor (SPF), which is defined as the ratio of the amount of energy required to produce minimal erythema on sunscreen-protected skin to the amount of energy required to produce the same level of erythema on unprotected skin.

[0006] Many chemical absorbers and physical blockers (hereinafter referred to as "UV radiation absorbers") commonly used in sunscreen formulations are reported to have perceived adverse toxicological effects, perceived negative sensory effects, and perceived negative environmental impacts, which discourage some people from using sunscreens. Therefore, it is desirable to reduce the level of UV radiation absorbers present in sunscreen formulations without reducing the SPF protection. Therefore, a variety of SPF boosters for water-based sunscreen formulations have been developed to reduce the level of UV radiation absorbers without reducing the SPF protection provided.

[0007] To this end, a method for improving the UV radiation absorption of a composition containing at least one UV radiation absorber by incorporating latex particles having voids is disclosed in U.S. Patent No. 5,663,213 issued to Jones et al. Jones et al. disclose a method for improving the UV radiation absorption of a composition comprising: adding to the composition from about 0.1 wt % to about 50 wt % of latex particles based on the total weight of non-volatile matter, wherein the composition comprises at least one UV radiation absorber, wherein the latex particles contain voids and have a particle size of from about 100 nm to about 380 nm, and wherein the latex particles are added to increase the UV radiation absorption of the composition.

[0008] Despite this, alcohol-based sunscreen products (eg, sprays) account for as much as 50% of the market. High alcohol content (eg, >60 wt% ethanol) sunscreens are a popular format for which many conventional SPF booster supplies are not suitable.

[0009] In order to achieve the desired SPF rating in organic carrier-based (sprayable) sunscreen formulations, conventional formulations incorporate high levels of expensive UV absorbers. While increasing the cost of the formulation, the incorporation of high levels of UV absorbers also adversely impairs the aesthetics of these conventional formulations, often imparting a sticky or gritty feel to the skin.

[0010] Thus, there remains a need for new alcohol-based sunscreen formulations that provide effective SPF ratings while reducing the necessary incorporation levels of UV absorbers and improving the aesthetics of the formulation during use.

[0011] The present invention provides an SPF enhancer, which comprises: functionalized maltodextrin, wherein the functionalized maltodextrin comprises -Si(R 1 ) 3A maltodextrin base polymer functionalized with a group; wherein each R 1 Independently C 1-10 A linear or branched saturated alkyl group; wherein the maltodextrin base polymer has a dextrose equivalent DE of 1 to 15; wherein the functionalized maltodextrin has a -Si(R 1 ) 3 The functionalized maltodextrin contains no vinyl carbon.

[0012] The present invention provides a sunscreen preparation, which comprises: a dermatologically acceptable organic carrier; a UV radiation absorber; and an SPF enhancer, wherein the SPF enhancer comprises a functionalized maltodextrin, wherein the functionalized maltodextrin comprises a -Si(R 1 ) 3 A maltodextrin base polymer functionalized with a group; wherein each R 1 Independently C 1-10 A linear or branched saturated alkyl group; wherein the maltodextrin base polymer has a dextrose equivalent DE of 1 to 15; wherein the functionalized maltodextrin has a -Si(R 1 ) 3 The functionalized maltodextrin contains no vinyl carbon.

[0013] The present invention provides a method of protecting the skin from exposure to sunlight, the method comprising: providing a sunscreen formulation of the present invention, and applying the sunscreen formulation to the skin. DETAILED DESCRIPTION

[0014] Surprisingly, an SPF booster has been discovered comprising a functionalized maltodextrin comprising a -Si(R 1 ) 3 A maltodextrin base polymer functionalized with a group; wherein each R 1 Independently C 1-10 A linear or branched saturated alkyl group; wherein the maltodextrin base polymer has a dextrose equivalent DE of 1 to 15; wherein the functionalized maltodextrin has a -Si(R 1 ) 3 The functionalized maltodextrin contains no vinyl carbons. The SPF boosters of the present invention are based on biological and biodegradable materials. In addition, it has been surprisingly found that the SPF boosters of the present invention provide SPF boosts when incorporated into alcohol-based sunscreen formulations having desirable aesthetic properties.

[0015] Unless otherwise indicated, ratios, percentages, parts, etc. are by weight.

[0016] The term "dextrose equivalent DE" as used herein and in the appended claims refers to the degree of starch hydrolysis, specifically, the reducing value of a starch hydrolysate material compared to the reducing value of an equal weight of dextrose, expressed as a percentage on a dry basis, as measured by the Lane and Eynon method described in Standard Analytical Method E-26, Corn Refiners Association, 6th Edition, 1977, E-26, pp. 1-3. For example, a maltodextrin with a DE of 10 will have 10% of the reducing power of a dextrose with a DE of 100.

[0017] As used herein and in the appended claims, the term "vinyl carbon" refers to a carbon that participates in a double bond with another carbon.

[0018] As used herein and in the appended claims, the term "free of vinyl carbon" with respect to functionalized maltodextrin means that the functionalized maltodextrin contains vinyl carbon below the detectable limit.

[0019] As used herein and appended hereto, the term "dermatologically acceptable" refers to ingredients typically used in personal care compositions and is intended to emphasize that materials that are toxic when present in amounts typically found in personal care compositions are not contemplated as part of this invention.

[0020] As used herein and in the appended claims, the term "aesthetic characteristics" refers to visual and tactile sensory properties (eg, smoothness, stickiness, lubricity, texture, color, clarity, turbidity, uniformity).

[0021] Preferably, the sunscreen preparation of the present invention is provided in a product form selected from the group consisting of: cream, non-aqueous solution, oil, ointment, paste, gel, lotion, milk, foam, stick and suspension. More preferably, the sunscreen preparation of the present invention is provided in the form of a non-aqueous solution. Most preferably, the sunscreen preparation of the present invention is formulated to use a mechanical device (e.g., a manual pump spray container, a squeeze bottle) or a pressurized aerosol container (e.g., a nozzle bag container, a pressurized can) to generate a spray for application to the skin.

[0022] Preferably, the SPF booster of the present invention comprises functionalized maltodextrin, wherein the functionalized maltodextrin comprises a -Si(R 1 ) 3 A maltodextrin base polymer functionalized with a group; wherein each R 1 Independently C 1-10A linear or branched saturated alkyl group (preferably, a methyl group, an ethyl group, a propyl group, a butyl group and a pentyl group; more preferably, a methyl group, an ethyl group, a propyl group and a butyl group; still more preferably, a methyl group, an ethyl group and a propyl group; still more preferably, a methyl group, an ethyl group and a propyl group; yet more preferably, a methyl group and an ethyl group; most preferably, a methyl group); wherein the maltodextrin base polymer has a dextrose equivalent DE of 1 to 15 (preferably, 1 to 12; more preferably, 1 to 10; most preferably, 1 to 7); wherein the functionalized maltodextrin has a -Si(R) of 1.7 to 3 1 ) 3 The degree of substitution DS of the functionalized maltodextrin group is preferably 1.8 to 3.0; more preferably 2 to 2.8; most preferably 2.1 to 2.55; and wherein the functionalized maltodextrin does not contain vinyl carbon. More preferably, the SPF booster of the present invention comprises functionalized maltodextrin comprising a functionalized maltodextrin with -Si(R 1 ) 3 The maltodextrin base polymer is functionalized with a group; wherein -Si(R 1 ) 3 The group is connected to the maltodextrin base polymer via a CO-Si bond; wherein each R 1 Independently C 1-10 A linear or branched saturated alkyl group (preferably, a methyl group, an ethyl group, a propyl group, a butyl group and a pentyl group; more preferably, a methyl group, an ethyl group, a propyl group and a butyl group; still more preferably, a methyl group, an ethyl group and a propyl group; still more preferably, a methyl group, an ethyl group and a propyl group; yet more preferably, a methyl group and an ethyl group; most preferably, a methyl group); wherein the maltodextrin base polymer has a dextrose equivalent DE of 1 to 15 (preferably, 1 to 12; more preferably, 1 to 10; most preferably, 1 to 7); wherein the functionalized maltodextrin has a -Si(R) of 1.7 to 3 1 ) 3 The degree of substitution DS of the groups (preferably, 1.8 to 3.0; more preferably, 2 to 2.8; most preferably, 2.1 to 2.55); and wherein the functionalized maltodextrin contains no vinyl carbons.

[0023] Preferably, the sunscreen formulation of the present invention comprises: a dermatologically acceptable organic carrier (based on the weight of the sunscreen formulation, preferably, 10 wt % to 98 wt % (more preferably, 25 wt % to 92 wt %; still more preferably, 35 wt % to 85 wt %; most preferably, 40 wt % to 80 wt %) of a dermatologically acceptable organic carrier); a UV radiation absorber (based on the weight of the sunscreen formulation, preferably, 0.1 wt % to 70 wt % (more preferably, 5 wt % to 65 wt %; still more preferably, 40 wt % to 80 wt %) of a dermatologically acceptable organic carrier); More preferably, 7.5 wt % to 60 wt %; most preferably, 10 wt % to 55 wt %) of UV radiation absorber); and an SPF booster (based on the weight of the sunscreen formulation, preferably 0.1 wt % to 70 wt % (more preferably, 1 wt % to 15 wt %; still more preferably, 1.5 wt % to 10 wt %; most preferably, 2 wt % to 6 wt %) of SPF booster); wherein the SPF booster comprises a functionalized maltodextrin comprising a functionalized maltodextrin having a -Si(R 1 ) 3 A maltodextrin base polymer functionalized with a group; wherein each R 1 Independently C 1-10 A linear or branched saturated alkyl group (preferably, a methyl group, an ethyl group, a propyl group, a butyl group and a pentyl group; more preferably, a methyl group, an ethyl group, a propyl group and a butyl group; still more preferably, a methyl group, an ethyl group and a propyl group; still more preferably, a methyl group, an ethyl group and a propyl group; yet more preferably, a methyl group and an ethyl group; most preferably, a methyl group); wherein the maltodextrin base polymer has a dextrose equivalent DE of 1 to 15 (preferably, 1 to 12; more preferably, 1 to 10; most preferably, 1 to 7); wherein the functionalized maltodextrin has a -Si(R) of 1.7 to 3 1 ) 3The degree of substitution DS of the group (preferably, 1.8 to 3.0; more preferably, 2 to 2.8; most preferably, 2.1 to 2.55); and wherein the functionalized maltodextrin does not contain vinyl carbon. More preferably, the sunscreen formulation of the present invention comprises: a dermatologically acceptable organic carrier (based on the weight of the sunscreen formulation, preferably, 10 wt % to 98 wt % (more preferably, 25 wt % to 92 wt %; still more preferably, 35 wt % to 85 wt %; most preferably, 40 wt % to 80 wt %) of a dermatologically acceptable organic carrier); a UV radiation absorber (based on the weight of the sunscreen formulation, preferably, 0.1 wt % to 70 wt % (more preferably, 5 wt % to 65 wt %; still more preferably, 40 wt % to 80 wt %) of a dermatologically acceptable organic carrier); More preferably, 7.5 wt % to 60 wt %; most preferably, 10 wt % to 55 wt %) of UV radiation absorber); and an SPF booster (based on the weight of the sunscreen formulation, preferably 0.1 wt % to 70 wt % (more preferably, 1 wt % to 15 wt %; still more preferably, 1.5 wt % to 10 wt %; most preferably, 2 wt % to 6 wt %) of SPF booster); wherein the SPF booster comprises a functionalized maltodextrin comprising a functionalized maltodextrin having a -Si(R 1 ) 3 The maltodextrin base polymer is functionalized with a group; wherein -Si(R 1 ) 3 The group is connected to the maltodextrin base polymer via a CO-Si bond; wherein each R 1 Independently C 1-10 A linear or branched saturated alkyl group (preferably, a methyl group, an ethyl group, a propyl group, a butyl group and a pentyl group; more preferably, a methyl group, an ethyl group, a propyl group and a butyl group; still more preferably, a methyl group, an ethyl group and a propyl group; still more preferably, a methyl group, an ethyl group and a propyl group; yet more preferably, a methyl group and an ethyl group; most preferably, a methyl group); wherein the maltodextrin base polymer has a dextrose equivalent DE of 1 to 15 (preferably, 1 to 12; more preferably, 1 to 10; most preferably, 1 to 7); wherein the functionalized maltodextrin has a -Si(R) of 1.7 to 3 1 ) 3 The degree of substitution DS of the groups (preferably, 1.8 to 3.0; more preferably, 2 to 2.8; most preferably, 2.1 to 2.55); and wherein the functionalized maltodextrin contains no vinyl carbons.

[0024] Preferably, the maltodextrin base polymer has a dextrose equivalent DE of 1 to 15 (preferably, 1 to 12; more preferably, 1 to 10; most preferably, 1 to 7). More preferably, the maltodextrin base polymer has a dextrose equivalent DE of 1 to 15 (preferably, 1 to 12; more preferably, 1 to 10; most preferably, 1 to 7); wherein the maltodextrin base polymer is a linear or branched maltodextrin polymer comprising a plurality of glucose structural units. Most preferably, the maltodextrin base polymer has a dextrose equivalent DE of 1 to 15 (preferably, 1 to 12; more preferably, 1 to 10; most preferably, 1 to 7); wherein the maltodextrin base polymer is a linear or branched maltodextrin polymer comprising a plurality of glucose structural units; wherein 90 mol% to 100 mol% (preferably, 92 mol% to 100 mol%; more preferably, 93 mol% to 100 mol%; most preferably, 94.5 mol% to 100 mol%) of the glucose structural units are linked by α-1,4 bonds, and 0 mol% to 10 mol% (preferably, 0 mol% to 8 mol%; more preferably, 0 mol% to 7 mol%; most preferably, 0 mol% to 5.5 mol%) of the glucose structural units are linked by α-1,6 bonds.

[0025] Preferably, the maltodextrin base polymer contains less than 0.01 wt. % alternan, based on the weight of the maltodextrin base polymer. More preferably, the maltodextrin base polymer contains less than 0.001 wt. % alternan, based on the weight of the maltodextrin base polymer. Most preferably, the maltodextrin base polymer contains alternan below the detectable limit.

[0026] Preferably, <0.1 mol % (preferably, <0.01 mol %; more preferably, <0.001 mol %; most preferably, < detectable limit) of the glucose building blocks in the maltodextrin base polymer are linked via β-1,4 bonds.

[0027] Preferably, <0.1 mol % (preferably, <0.01 mol %; more preferably, <0.001 mol %; most preferably, < detectable limit) of the glucose building blocks in the maltodextrin base polymer are linked via β-1,3 bonds.

[0028] Preferably, the sunscreen formulation of the present invention comprises, based on the weight of the sunscreen formulation, 10% to 98% by weight (preferably, 25% to 92% by weight; more preferably, 35% to 85% by weight; most preferably, 40% to 80% by weight) of a dermatologically acceptable organic carrier. More preferably, the sunscreen formulation of the present invention comprises 10% to 98% by weight (preferably, 25% to 92% by weight; more preferably, 35% to 85% by weight; most preferably, 40% to 80% by weight) of a dermatologically acceptable organic carrier; wherein the dermatologically acceptable organic carrier is selected from the group consisting of: a glycol (e.g., ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, dipropylene glycol, ethoxydiglycol); C 1-10 Straight or branched alcohols (e.g., methanol, ethanol, propanol, isopropanol, butanol, 2-butoxyethanol); ketones (e.g., acetone); acetates (e.g., methyl acetate); butyl cellosolve; dimethicone; polydimethylsiloxane; alkanes (e.g., isododecane, isohexane); alkanoates (e.g., methyl undecanoate), dermatologically acceptable hydrophobic ester oils (e.g., caprylic capric triglyceride); dicaprylyl carbonate; alkyl benzoates (e.g., C benzoate); 12-15 alkyl esters); hemi-squalane; dicaprylyl ether; keto acids (e.g., levulinic acid) and mixtures thereof. Still more preferably, the sunscreen formulations of the present invention comprise 10% to 98% by weight (preferably, 25% to 92% by weight; more preferably, 35% to 85% by weight; most preferably, 40% to 80% by weight) of a dermatologically acceptable organic carrier; wherein the dermatologically acceptable organic carrier is selected to be able to evaporate when the sunscreen formulation is applied to the skin. Still more preferably, the sunscreen formulations of the present invention comprise 10% to 98% by weight (preferably, 25% to 92% by weight; more preferably, 35% to 85% by weight; most preferably, 40% to 80% by weight) of a dermatologically acceptable organic carrier; wherein the dermatologically acceptable organic carrier comprises C 1-4 Straight or branched alcohol (e.g., methanol, ethanol, propanol, isopropanol, butanol) (preferably, wherein the alcohol is a denatured alcohol). Most preferably, the sunscreen formulations of the present invention comprise 10% to 98% by weight (preferably, 25% to 92% by weight; more preferably, 35% to 85% by weight; most preferably, 40% to 80% by weight) of a dermatologically acceptable organic carrier; wherein the dermatologically acceptable organic carrier comprises a specific denatured ethanol (e.g., INCI: SD ALCOHOL 40-B; INCI: DENATED ALCOHOL).

[0029] Preferably, the sunscreen formulations of the present invention comprise 0.1 wt% to 70 wt% (preferably 5 wt% to 65 wt%; more preferably 7.5 wt% to 60 wt%; most preferably 10 wt% to 55 wt%) of UV radiation absorber, based on the weight of the sunscreen formulation. More preferably, the sunscreen formulation of the present invention comprises 0.1 wt.% to 70 wt.% (preferably, 5 wt.% to 65 wt.%; more preferably, 7.5 wt.% to 60 wt.%; most preferably, 10 wt.% to 55 wt.%) of a UV radiation absorber; wherein the UV radiation absorber is selected from the group consisting of: physical blockers (e.g., red petrolatum, titanium dioxide, zinc oxide); chemical absorbers (e.g., 1-(4-methoxyphenol)-3-(4-tert-butylphenyl)propane-1,3-dione (INCI: avobenzone), 2-hydroxy-4-methoxybenzophenone (INCI: oxybenzone); dihydroxybenzone; sulisophenone; menthyl anthranilate; p-aminobenzoic acid; p-dimethylaminobenzoic acid valeric acid; p-dimethylaminobenzoic acid octyl ester; 4-bis(hydroxypropyl) ethyl p-aminobenzoate; polyethylene glycol (PEG-25) p-aminobenzoate; 4-bis(hydroxypropyl) )Ethyl aminobenzoate; Diethanolamine p-methoxycinnamate; 2-ethoxyethyl p-methoxycinnamate; Ethylhexyl p-methoxycinnamate; Octyl p-methoxycinnamate; Isoamyl p-methoxycinnamate; 2-ethylhexyl-2-cyano-3,3-diphenyl-acrylate; 2-ethylhexyl-2-cyano-3,3-diphenyl-2-acrylate (INCI: Octocrylene); 2-ethylhexyl 2-hydroxybenzoate (INCI: Water Salicylate (octyl salicylate); homomanic salicylate; aminobenzoic acid glyceryl ester; salicylic acid triethanolamine; gallyl gallate trioleate; dihydroxyacetone-containing hyaluronan; 2-phenylbenzimidazole-5-sulfonic acid; 4-methylbenzylidene camphor; avobenzone; triazine; benzotriazole; amide containing a vinyl group; cinnamic acid amide; sulfonated benzimidazole; 2-hydroxybenzoic acid 3,3,5-trimethylcyclohexyl ester (INCI: homosalate); and mixtures thereof. Still more preferably, the sunscreen formulation of the present invention comprises 0.1% to 70% by weight (preferably, 5% to 65% by weight; more preferably, 7.5% to 60% by weight; most preferably, 10% to 55% by weight) of a UV radiation absorber, wherein the UV radiation absorber comprises a mixture of UV radiation absorbers.Still more preferably, the sunscreen formulations according to the invention comprise from 0.1% to 70% by weight (preferably from 5% to 65% by weight; more preferably from 7.5% to 60% by weight; most preferably from 10% to 55% by weight) of a UV radiation absorber, wherein the UV absorber is a mixture of UV absorbers comprising at least one of: 1-(4-methoxyphenol)-3-(4-tert-butylphenyl)propane-1,3-dione (INCI: Avobenzone); 2-ethylhexyl 2-hydroxybenzoate (INCI: OCTYL SALICYLATE); 2-ethylhexyl-2-cyano-3,3-diphenyl-2-acrylate (INCI: OCTOCRYLENE); 2-hydroxy-4-methoxybenzophenone (INCI: OXYBENZOONE) and 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate (INCI: HOMOSALICATE). Most preferably, the sunscreen formulations of the present invention comprise 0.1 wt.% to 70 wt.% (preferably 5 wt.% to 65 wt.%; more preferably 7.5 wt.% to 60 wt.%; most preferably 10 wt.% to 55 wt.%) of a UV radiation absorber, wherein the UV absorber is a mixture of UV absorbers including 1-(4-methoxyphenol)-3-(4-tert-butylphenyl)propane-1,3-dione (INCI: Avobenzone); 2-ethylhexyl 2-hydroxybenzoate (INCI: OCTYL SALICYLATE); 2-ethylhexyl-2-cyano-3,3-diphenyl-2-acrylate (INCI: OCTOCRYLENE) and 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate (INCI: Homosalate).

[0030] Preferably, the sunscreen formulations of the present invention have an SPF of ≥10 (more preferably, ≥20; still more preferably, ≥25; yet more preferably, ≥30; most preferably, ≥35) (preferably, wherein the SPF of the formulation is measured as described in the Examples).

[0031] Preferably, the sunscreen formulations of the present invention contain less than 5 wt% (more preferably, <4 wt%; still more preferably, <3 wt%; yet more preferably, <2 wt%; most preferably, <1 wt%) water.

[0032] Preferably, the sunscreen formulation of the present invention further comprises optional additives. More preferably, the sunscreen formulation of the present invention further comprises optional additives, wherein the optional additives are selected from the group consisting of: film formers, water repellents, emollients, preservatives, antioxidants, fragrances, humectants, rheology modifiers, aesthetic modifiers, propellants, vitamins, skin protectants, oils, emulsifiers, surfactants, pearlescent agents, consistency factors, thickeners, super fat enhancers, stabilizers, polymers, silicone compounds, fats, waxes, lecithin, phospholipids and mixtures thereof.

[0033] Preferably, the sunscreen formulation of the present invention further comprises a film former. More preferably, the sunscreen formulation of the present invention further comprises 0.1 wt % to 10 wt % (preferably, 0.5 wt % to 9 wt %; more preferably, 0.7 wt % to 5 wt %) of a film former. Most preferably, the sunscreen formulation of the present invention further comprises 0.1 wt % to 10 wt % (preferably, 0.5 wt % to 9 wt %; more preferably, 0.7 wt % to 5 wt %) of a film former; wherein the film former is selected to provide a film barrier when the sunscreen formulation of the present invention is applied to the skin. The purpose of the film barrier is to help maintain the UV radiation absorber on the skin after immersion in water.

[0034] Preferred film formers include petrolatum; emollient esters (e.g. C 8-24 Alkyl triglycerides (preferably aliphatic C 12-24 Alkyl triglyceride; more preferably, aliphatic C >12-24 Alkyl triglycerides; most preferably, caprylic / capric triglycerides); lanolin derivatives (e.g., acetylated lanolin); superfatting oils; silicone gums; silicone elastomers; silicone resins; phenyl functionalized silicones; silicone acrylates; dimethicone derivatives; natural and synthetic oils; fatty acids; fatty alcohols; waxes; acrylic acid copolymers; polyamides; polyesters; polysaccharides; acrylate polymers and mixtures thereof.

[0035] Acrylic copolymers include acrylamide / acrylic acid copolymers (e.g., available from National Starch and Chemical). 79 (INCI: Acrylates / Octyl Acrylamide Copolymer)); Acrylates copolymers (e.g., EPITAX available from The Dow Chemical Company TM 66 Powder Water Repellent Polymer (INCI: Acrylates Copolymer)).

[0036] Certain emollients also exhibit film-forming properties by providing a water-resistant barrier on the skin. Emollients that exhibit film-forming properties include butyl octyl salicylate (e.g., available from HallStar Corporation). BHB); fatty acids (e.g., oleic acid, stearic acid); fatty alcohols (e.g., cetyl alcohol, hexadecanol); esters (e.g., 2,2-dimethyl-1,3-propanediyl diheptanoate (INCI: neopentyl glycol diheptanoate)); alkanes (e.g., mineral oil); ethers (e.g., polyoxypropylene butyl ether, polyoxypropylene cetyl ether); natural oils and synthetic oils (including silicone oils).

[0037] Preferred propellants for use in the sunscreen formulations of the present invention include methane, ethane, propane, isobutane, n-butane, hexane, heptane, dimethyl ether, diethyl ether, fluorinated materials (e.g., 1,1-difluoroethane, ethyl perfluoroisobutyl ether, ethyl perfluorobutyl ether, methyl perfluoroisobutyl ether, methyl perfluorobutyl ether) and mixtures thereof. Preferred fluorinated propellants include Cosmetic Fluid CF-76 (INCI name: ethyl perfluorobutyl ether / ethyl perfluoroisobutyl ether) and Cosmetic Fluid CF-61 (INCI name: methyl perfluorobutyl ether / methyl perfluoroisobutyl ether).

[0038] The sunscreen formulations of the present invention are suitable for protecting the skin. Preferably, the sunscreen formulations of the present invention can be used to protect the skin from UV damage caused by exposure to sunlight. The sunscreen formulations of the present invention also preferably provide moisturizing of the skin, prevention and treatment of dry skin, protection of sensitive skin, improvement of skin color and skin texture, concealment of blemishes and inhibition of transepidermal water loss. Therefore, in one aspect, the present invention provides that the sunscreen formulation can be used in a method for protecting the skin from UV damage, which method comprises topically applying the sunscreen formulation to the skin (preferably, mammalian skin; more preferably, human skin).

[0039] Some embodiments of the present invention will now be described in detail in the following examples.

[0040] Synthesis S1: Silylated maltodextrin

[0041] Combine ammonium chloride (412.4 mg, 0.05 eq.) and 1 maltodextrin (DE 1, from Roquette) (25.0 g, 0.154 mol, 1.0 eq.). The resulting mixture was transferred to the reactor. Hexamethyldisilazane (80.87 g, 3.25 eq.) was then added dropwise to the reactor contents. Dimethyl sulfoxide (10.8 g) was then added to the reactor contents. The reactor was then sealed and flushed continuously with nitrogen. The reactor contents were stirred at 20 Hz. Heat was applied to the reactor using a heating jacket set at 40 ° C, and stirring was increased to 50 Hz. After 30 minutes, the heating jacket was set to 50 ° C. The temperature setting of the heating jacket was then increased to 80 ° C in increments of 10 ° C within 1 hour. After the temperature of the reactor contents reached 71 ° C, the reactor contents were stirred for 1 hour. The heating jacket was then removed and stirring was reduced to 25 Hz. When the reactor contents cooled to <50 ° C, stirring was stopped and 400 mL of ethyl acetate was added to the reactor contents. Stirring was then continued at 25 Hz for 5 minutes. Stirring was then stopped and the organic layer was transferred to a collection tank. Ethyl acetate (100 mL) was then added to the reactor contents and stirring was continued at 25 Hz for 5 minutes. Stirring was then stopped and the organic layer was transferred to the contents of the collection tank. The contents of the collection tank were transferred to a separatory funnel and washed twice with distilled water (2×250 mL). The organic layer was collected in a conical flask and dried over sodium sulfate. The organic layer was then concentrated under vacuum to obtain a fine white powder (about 46.3 g). By 1 H NMR determination of -Si(CH 3 ) 3 The degree of substitution DS is 1.67.

[0042] Synthesis S2: Silylated maltodextrin

[0043] Combine ammonium chloride (454.4 mg, 0.05 eq.) and 1 maltodextrin (DE 1, from Roquette) (27.0g, 0.166mol, 1.0 equivalent). The resulting mixture is transferred to the reactor. Then hexamethyldisilazane (87.34g, 3.25 equivalents) is added dropwise to the reactor contents. Then dimethyl sulfoxide (11.66g) is added to the reactor contents. The reactor is then sealed and flushed continuously with nitrogen. The reactor contents are stirred at 20Hz. A heating jacket with a temperature setting of 92°C is used to apply heat to the reactor, and stirring is increased to 50Hz. After the temperature of the reactor contents reaches 83°C, the reactor contents are stirred for 1.5 hours. The heating jacket is then removed and stirring is reduced to 25Hz. When the reactor contents are cooled to <50°C, stirring is stopped and 400mL of ethyl acetate is added to the reactor contents. Then stirring is continued for 5 minutes at 25Hz. Then stirring is stopped and the organic layer is transferred to a collection tank. Then ethyl acetate (100mL) is added to the reactor contents, and stirring is continued for 5 minutes at 25Hz. Then stop stirring and transfer the organic layer to the contents of the collection tank. Transfer the contents of the collection tank to a separatory funnel and wash twice with distilled water (2 x 250 mL). Collect the organic layer in a conical flask and dry over sodium sulfate. The organic layer is then concentrated under vacuum to give a fine white powder (about 56.6 g). 1 H NMR determination of -Si(CH 3 ) 3 The degree of substitution DS is 2.1.

[0044] Synthesis S3: Silylated maltodextrin

[0045] Combine ammonium chloride (445.4 mg, 0.05 eq.) and 1 maltodextrin (DE 1, from Roquette) (27.0g, 0.167mol, 1.0 equivalent). The resulting mixture is transferred to the reactor. Then hexamethyldisilazane (60.47g, 2.25 equivalents) is added dropwise to the reactor contents. Then dimethyl sulfoxide (11.7g) is added to the reactor contents. The reactor is then sealed and flushed continuously with nitrogen. The reactor contents are stirred at 20Hz. Heat is applied to the reactor using a heating jacket set at 55°C, and stirring is increased to 50Hz. After 5 minutes, the heating jacket is set to 102°C. The reactor contents are stirred for 2 hours. The heating jacket is then removed and stirring is reduced to 25Hz. When the reactor contents are cooled to <50°C, stirring is stopped and 400mL of ethyl acetate is added to the reactor contents. Then stirring is continued for 5 minutes at 25Hz. Then stirring is stopped and the organic layer is transferred to a collection tank. Then ethyl acetate (100mL) is added to the reactor contents, and stirring is continued for 5 minutes at 25Hz. Then stop stirring and transfer the organic layer to the contents of the collection tank. Transfer the contents of the collection tank to a separatory funnel and wash twice with distilled water (2 x 250 mL). Collect the organic layer in a conical flask and dry over sodium sulfate. The organic layer is then concentrated under vacuum to give a fine white powder (about 407.3 g). 1 H NMR determination of -Si(CH 3 ) 3 The degree of substitution DS is 2.55.

[0046] Synthesis S4: Silylated maltodextrin

[0047] Ammonium chloride (33.0 mg, 0.05 eq) and Maltrin M250 maltodextrin (DE 23-27 from Grain Processing Corporation) (2.0 g, 12.3 mM, 1.0 eq) were added to a 25 mL scintillation vial. Hexamethyldisilazane (4.48 g, 2.25 eq) was then added dropwise to the vial contents. Dimethyl sulfoxide (1 g) was then added to the vial contents and the vial was capped with a screw cap septum with two venting needles on the top. The vial was placed on an aluminum heating block set to 85 °C for 1.5 hours. The vial contents were then cooled to <50 °C and diluted with ethyl acetate (150 mL). The organic layer was transferred to a separatory funnel and washed three times with distilled water (3×50 mL). The organic layer was collected in a conical flask and dried over sodium sulfate. The organic layer was then concentrated under vacuum to give a fine white powder (approximately 4.15 g). By 1 H NMR determination of -Si(CH 3 )3 The degree of substitution DS is 2.2.

[0048] Synthesis S5: Silylated cellulose

[0049] Polysaccharide (BioFloc XV, 15.0 g, from Tartas) was weighed in a 2L three-necked flask equipped with a nitrogen inlet and a temperature controller. Add solvent (N, N-dimethylacetamide, 331 g, from Sigma-Aldrich) and place the reaction mixture under a nitrogen atmosphere with an outlet to avoid reactor overpressure. Silane (hexamethyldisilazane, 30 g, from Dow Chemical Company) was added to the reaction mixture at one time. The mixture was slowly heated to a set temperature of 130 ° C and stirred for 7.5 hours. The solution was cooled naturally, and then xylene (600 g, from Sigma-Aldrich) was added to the reaction mixture together with another hexamethyldisilazane (20 g), and the mixture was stirred for 4 hours at a set temperature of 125 ° C. The reactor contents were cooled to room temperature overnight. Then, the reactor contents were transferred to a separatory funnel, and non-solvent precipitation was performed by dropwise addition to 2L of vigorously stirred methanol. The product was isolated by filtration and dried in a vacuum oven at 50° C. overnight. The product was then suspended in 500 ml of methanol and then filtered and dried in a vacuum oven at 50° C. overnight. The product was analyzed by attenuated total reflection infrared to determine a DS of 2.23.

[0050] Synthesis S6: Silylated cellulose

[0051] Polysaccharide (E-60, 15.2g, from GP Cellulose) was weighed in a 2L three-necked flask equipped with a nitrogen inlet and a temperature controller. Add solvent (N, N-dimethylacetamide, 324g) and place the reaction mixture under a nitrogen atmosphere with an outlet to avoid reactor overpressure. Silane (hexamethyldisilazane, 50.2g, from Dow Chemical Company) was added to the reaction mixture at one time with saccharin catalyst (850mg, from Sigma-Aldrich). The mixture was slowly heated to a set temperature of 130°C and stirred for 5 hours. The solution was cooled naturally, then xylene (400g) was added to the reaction mixture and the mixture was stirred at 120°C for 8 hours. The reactor contents were cooled to room temperature overnight. Then, the cooled reactor contents were transferred to a separatory funnel, and non-solvent precipitation was carried out by dropwise addition to 2L of vigorously stirred methanol. The product was separated by filtration and dried overnight at 50°C in a vacuum oven. The product was then suspended in 500 ml of methanol, then filtered again and dried overnight in a vacuum oven at 50° C. The DS was determined to be 2.6 by attenuated total reflection infrared analysis.

[0052] Synthesis S7: Silylated maltodextrin

[0053] To a 25 mL scintillation vial was added ammonium chloride (33.0 mg, 0.05 eq) and Maltrin M200 maltodextrin (DE range 16.5-19.9, from Grain Processing Company) (2.0 g, 12.3 mM, 1.0 eq). Hexamethyldisilazane (3.58 g, 1.80 eq) was then added dropwise to the vial contents. Dimethyl sulfoxide (0.75 g) was then added to the vial contents, and the vial was equipped with a septum cap with two vent needles. The vial was placed on a heating block set to 80 °C for 1 hour. The vial contents were then cooled to <50 °C and diluted with ethyl acetate (150 mL). The organic layer was transferred to a separatory funnel and washed three times with distilled water (3×50 mL). The organic layer was collected in a conical flask and dried over sodium sulfate. The organic layer was then concentrated under vacuum to give a fine white powder (approximately 3.6 g). By 1 H NMR determination of -Si(CH 3 ) 3 The degree of substitution DS is 2.76.

[0054] Synthesis S8: Silylated maltodextrin

[0055] To a 25 mL scintillation vial was added ammonium chloride (33.0 mg, 0.05 eq) and Maltrin M040 (DE 4-7 from Grain Processing Company) (2.0 g, 12.3 mM, 1.0 eq). Hexamethyldisilazane (4.48 g, 2.25 eq) was then added dropwise to the vial contents. Dimethyl sulfoxide (1 g) was then added to the vial contents, and the vial was equipped with a septum cap with two vent needles. The vial was placed on a heating block set to 85 °C for 1.5 hours. The vial contents were then cooled to <50 °C and diluted with ethyl acetate (150 mL). The organic layer was transferred to a separatory funnel and washed three times with distilled water (3×50 mL). The organic layer was collected in a conical flask and dried over sodium sulfate. The organic layer was then concentrated under vacuum to give a fine white powder (approximately 4.15 g). By 1 HNMR determination of -Si(CH 3 ) 3 The degree of substitution DS is 2.5.

[0056] Synthesis S9: Silylated maltodextrin

[0057] Combine ammonium chloride (445.4 mg, 0.05 eq.) and 1 maltodextrin (DE 1, from Roquette) (27.0g, 0.166mol, 1.0 equivalent). The resulting mixture is transferred to the reactor. Then hexamethyldisilazane (87.34g, 3.25 equivalents) is added dropwise to the reactor contents. Then dimethyl sulfoxide (11.66g) is added to the reactor contents. The reactor is then sealed and flushed continuously with nitrogen. The reactor contents are stirred at 20Hz. A heating jacket with a temperature setting of 50°C is used to apply heat to the reactor, and stirring is increased to 50Hz. After 20 minutes, the heating jacket is set to 100°C. The reactor contents are stirred for 2 hours. The heating jacket is then removed and stirring is reduced to 25Hz. When the reactor contents are cooled to <50°C, stirring is stopped and 400mL of ethyl acetate is added to the reactor contents. Then stirring is continued for 5 minutes at 25Hz. Then stirring is stopped and the organic layer is transferred to a collection tank. Ethyl acetate (100 mL) was then added to the reactor contents and stirring was continued at 25 Hz for 5 minutes. Stirring was then stopped and the organic layer was transferred to the contents of the collection tank. The contents of the collection tank were transferred to a separatory funnel and washed twice with distilled water (2×250 mL). The organic layer was collected in a conical flask and dried over sodium sulfate. The organic layer was then concentrated under vacuum to obtain a fine white powder (about 53 g). 1 H NMR determination of -Si(CH 3 ) 3 The degree of substitution DS is 2.23.

[0058] Synthesis of S10: Silylated maltodextrin

[0059] To a 25 mL scintillation vial was added ammonium chloride (33.0 mg, 0.05 eq) and 1 maltodextrin (DE1, from Roquette) (2.0 g, 12.3 mM, 1.0 equiv). Hexamethyldisilazane (4.48 g, 2.25 equiv) was then added dropwise to the vial contents. Dimethyl sulfoxide (1 g) was then added to the vial contents, and the vial was equipped with a septum cap with two vent needles. The vial was placed on a heating block set to 85°C for 2 hours. The vial contents were then cooled to <50°C and diluted with ethyl acetate (150 mL). The organic layer was transferred to a separatory funnel and washed three times with distilled water (3×50 mL). The organic layer was collected in a conical flask and dried over sodium sulfate. The organic layer was then concentrated under vacuum to give a fine white powder (approximately 3.96 g). By 1 HNMR determination of -Si(CH 3 ) 3 The degree of substitution DS is 2.51.

[0060] Synthesis of S11: Silylated maltodextrin

[0061] Combine ammonium chloride (445.4 mg, 0.05 eq.) and 1 maltodextrin (DE 1, from Roquette) (27.0g, 0.166mol, 1.0 equivalent). The resulting mixture is transferred to the reactor. Then hexamethyldisilazane (87.34g, 3.25 equivalents) is added dropwise to the reactor contents. Then dimethyl sulfoxide (11.66g) is added to the reactor contents. The reactor is then sealed and flushed continuously with nitrogen. The reactor contents are stirred at 20Hz. A heating jacket with a temperature setting of 50°C is used to apply heat to the reactor, and stirring is increased to 50Hz. After 20 minutes, the heating jacket is set to 100°C. The reactor contents are stirred for 2 hours. The heating jacket is then removed and stirring is reduced to 25Hz. When the reactor contents are cooled to <50°C, stirring is stopped and 400mL of ethyl acetate is added to the reactor contents. Then stirring is continued for 5 minutes at 25Hz. Then stirring is stopped and the organic layer is transferred to a collection tank. Ethyl acetate (100 mL) was then added to the reactor contents and stirring was continued at 25 Hz for 5 minutes. Stirring was then stopped and the organic layer was transferred to the contents of the collection tank. The contents of the collection tank were transferred to a separatory funnel and washed twice with distilled water (2×250 mL). The organic layer was collected in a conical flask and dried over sodium sulfate. The organic layer was then concentrated under vacuum to obtain a fine white powder (about 56.3 g). 1 H NMR determination of -Si(CH 3 ) 3 The degree of substitution DS is 2.42.

[0062] Synthesis of S12: Silylated maltodextrin

[0063] To a 25 mL scintillation vial was added ammonium chloride (24.7 mg, 0.05 eq) and dried 1 maltodextrin (DE 1, from Roquette) (1.5 g, 3.25 eq.). Hexamethyldisilazane (4.85 g, 3.25 eq.) was then added dropwise to the vial contents. Dimethyl sulfoxide (0.8 g) was then added to the vial contents, and the vial was equipped with a septum cap with two vent needles. The vial was placed on a heating block set to 90°C for 4 hours. The vial contents were then cooled to <50°C and diluted with ethyl acetate (200 mL). The organic layer was transferred to a separatory funnel and washed three times with a 50 / 50 vol / vol mixture of brine and distilled water (3×60 mL). The organic layer was collected in a conical flask and dried over sodium sulfate. The organic layer was then concentrated under vacuum to give an off-white crystalline solid, which was easily reduced to a fine powder with a spatula. The product powder was dried in an oven at 50°C under vacuum for 5 hours. By 1 H NMR determination of -Si(CH 3 ) 3 The degree of substitution DS is 2.42.

[0064] Synthesis of S13: Silylated maltodextrin

[0065] Ammonium chloride (24.7 mg, 0.05 eq.) and dry Maltrin M150 maltodextrin (DE 13-17, from a grain processing company) (1.5 g, 1.0 eq.) were added to a 25 mL scintillation vial. Hexamethyldisilazane (4.85 g, 3.25 eq.) was then added dropwise to the vial contents. Dimethyl sulfoxide (0.8 g) was then added to the vial contents, and the vial was equipped with a septum cap with two exhaust needles. The vial was placed on a heating block set at 90 ° C for 2.5 hours. The vial contents were then cooled to <50 ° C and diluted with ethyl acetate (200 mL). The organic layer was transferred to a separatory funnel and washed three times (3 × 60 mL) with a mixture of 50 / 50 vol / vol saline and distilled water. The organic layer was collected in a conical flask and dried over sodium sulfate. The organic layer was then concentrated under vacuum to give an off-white crystalline solid which was easily reduced to a fine powder with a spatula. The product powder was dried in an oven at 50 °C under vacuum for 5 hours. 1 H NMR determination of -Si(CH 3 ) 3 The degree of substitution DS is 2.64.

[0066] Synthesis of S14: Silylated maltodextrin

[0067] Ammonium chloride (33.0 mg, 0.05 equivalent) and Maltrin M200 maltodextrin (DE 20-23, from grain processing company) (2.0 g, 1.0 equivalent) were added to a 25 mL scintillation vial. Hexamethyldisilazane (3.58 g, 1.80 equivalent) was then added dropwise to the vial contents. Dimethyl sulfoxide (0.75 g) was then added to the vial contents, and the vial was equipped with a septum cap with two exhaust needles. The vial was placed on a heating block set at 80 ° C for 1 hour. The vial contents were then cooled to <50 ° C and diluted with ethyl acetate (150 mL). The organic layer was transferred to a separatory funnel and washed three times (3 × 50 mL) with a mixture of 50 / 50 vol / vol saline and distilled water. The organic layer was collected in a conical flask and dried over sodium sulfate. The organic layer was then concentrated under vacuum to obtain a fine white powder. The product powder was dried in an oven at 50 °C under vacuum for 5 hours. 1 H NMR determination of -Si(CH 3 ) 3 The degree of substitution DS is 2.45.

[0068] Solubility Screening (2 wt%)

[0069] As shown in Table 1, the solubility of the products of Synthesis S1-S7 in different carriers was evaluated by combining the products of Synthesis S1-S7 (0.1 g) with various solvents (4.9 g) in separate vials. The resulting 2 wt% solutions were stirred with a magnetic stirring bar at about 22°C for 1 hour. The carriers and solubility observations are provided in Table 1.

[0070] Table 1

[0071]

[0072] Solubility Screening (50 wt%)

[0073] The products of syntheses S2-S3 and S7 (2 g) were evaluated for solubility in isododecane (2 g) as shown in Table 2. The resulting 50 wt% solution was stirred with a magnetic stir bar at about 22° C. for 1 hour. The support and solubility observations are provided in Table 2.

[0074] Table 2

[0075]

[0076]

[0077] Viscosity in Isododecane

[0078] As shown in Table 3, the products of synthesizing S5-S6 and S9 were dissolved in isododecane at different concentrations. The viscosity of the resulting solution was then measured at about 22°C and 100 rpm using a Brookfield DV-111-ultra viscometer equipped with an SC4-28 spindle. The results are provided in Table 3.

[0079] Table 3

[0080] <![CDATA[ Solute ]]> <![CDATA[ Concentration (weight %) ]]> <![CDATA[ Viscosity(cP) ]]> Synthesis S5 2 3,500 Synthesis of S6 2 3,200 Synthesis of S6 5 gel Synthesis of S9 2 0 Synthesis of S9 5 2 Synthesis of S9 20 5 Synthesis of S9 40 305 Synthesis of S9 50 1,260

[0081] Comparative Examples CF1-CF6 and Examples F1-F4: Sunscreen Formulations

[0082] A sunscreen formulation having the composition as in Table 4 was prepared. Avobenzone, caprylic / capric triglyceride, and ethylhexyl salicylate were mixed in a flask and heated to 60°C until all the avobenzone was melted. The heat source was removed and the remaining ingredients except ethanol were added to the contents of the flask. When the contents of the flask cooled to <30°C, ethanol was added under stirring for 30 minutes until the contents of the flask were homogeneous.

[0083] Table 4

[0084]

[0085]

[0086] Sunscreen formulation clarity

[0087] The clarity of the sunscreen formulations prepared according to Comparative Examples CF1-CF3 and Example F3 was observed. The observation results are provided in Table 5.

[0088] Viscosity

[0089] The viscosity of the sunscreen formulations prepared according to Comparative Examples CF1-CF3 and Example F1 was measured at about 22°C using a TA Instruments DHR-3 Rheometer equipped with a spindle 27 rotating at 250 rpm. The measured viscosities are reported in Table 5.

[0090] Table 5

[0091]

[0092] In vitro SPF performance

[0093] The SPF performance of the sunscreen formulations prepared according to Comparative Examples CF1-CF2, CF4-CF6 and Examples F1-F4 was evaluated. The SPF performance of each of the sunscreen formulations was then tested in triplicate using an in vitro technique according to the following protocol.

[0094] The substrate used for in vitro SPF measurements was a rough PMMA substrate (6 μm-HD6, available from Schonberg GMBH & Co. KG). The sunscreen formulations to be tested were each applied to three separate rough 5 cm x 5 cm PMMA substrates using an RDS #7 silk pull-down rod at 1.3 mg / cm 2 The rate of providing a uniform sunscreen formulation layer on the PMMA substrate surface. Make each deposited layer of sunscreen formulation dry (60) minutes under laboratory environment conditions.Then use Labsphere UV-2000S spectrometer to measure the UV absorption between 290nm and 400nm of each dried layer of sunscreen formulation on nine (9) separate points.Then based on the UV absorption measurement result, calculate the in vitro SPF value of every kind of sunscreen formulation prepared according to Comparative Examples CF1-CF2, CF4-CF6 and Example F1-F4.The mean value of triplicate samples of every kind of sunscreen formulation prepared according to Comparative Examples CF1-CF2, CF4-CF6 and Example F1-F4 is reported in Table 6.

[0095] Table 6

[0096]

Claims

1. An SPF booster, comprising: Functionalized maltodextrin, the functionalized maltodextrin comprising -Si(R 1 )3 groups functionalized maltodextrin base polymer; wherein each R 1 Independently C 1-10 A linear or branched saturated alkyl group; wherein the maltodextrin base polymer has a dextrose equivalent DE of 1 to 15; wherein the functionalized maltodextrin has a -Si(R 1 )3 groups; and wherein the functionalized maltodextrin does not contain vinyl carbons.

2. A sunscreen preparation, comprising: a dermatologically acceptable organic carrier; UV radiation absorbers; and The SPF booster according to claim 1.

3. The sunscreen formulation according to claim 2, wherein the dermatologically acceptable organic carrier is selected from the group consisting of glycols (e.g., ethylene glycol, propylene glycol, butylene glycol, pentylene glycol, hexylene glycol, dipropylene glycol, ethoxydiglycol), C 1-4 Straight or branched chain alcohols (e.g., methanol, ethanol, propanol, isopropyl alcohol, butanol), acetone, methyl acetate, butyl cellosolve, dimethicone, isododecane, isohexadecane, methyl undecanoate, dermatologically acceptable hydrophobic ester oils (e.g., caprylic capric triglyceride), dicaprylyl carbonate, C benzoate 12-15 Alkyl esters, semisqualane, dioctyl ether, levulinic acid and mixtures thereof.

4. The sunscreen formulation of claim 3, wherein the UV radiation absorber is selected from the group consisting of physical blockers, chemical absorbers, and mixtures thereof.

5. The sunscreen formulation of claim 3, wherein the UV radiation absorber is selected from the group consisting of: red petrolatum; titanium dioxide; zinc oxide; 1-(4-methoxyphenol)-3-(4-tert-butylphenyl)propane-1,3-dione; 2-hydroxy-4-methoxybenzophenone; dihydroxybenzoate; sulisophenone; menthyl anthranilate; p-aminobenzoic acid; p-dimethylaminobenzoic acid valeric acid; p-dimethylaminobenzoic acid octyl ester; 4-bis(hydroxypropyl) p-aminobenzoic acid ethyl ester; polyethylene glycol (PEG-25) p-aminobenzoate; 4-bis(hydroxypropyl) aminobenzoic acid ethyl ester; p-methoxycinnamic acid diethanolamine; p-methoxycinnamic acid 2-ethoxyethyl ester; p-methoxycinnamic acid Ethylhexyl oxycinnamate; Octyl p-methoxycinnamate; Isoamyl p-methoxycinnamate; 2-ethylhexyl-2-cyano-3,3-diphenyl-acrylate; 2-ethylhexyl-2-cyano-3,3-diphenyl-2-acrylate; 2-ethylhexyl-2-hydroxybenzoate; Homomenate salicylate; Glyceryl aminobenzoate; Triethanolamine salicylate; Gallylgallic acid trioleate; Lawn quinone containing dihydroxyacetone; 2-phenylbenzimidazole-5-sulfonic acid; 4-methylbenzylidene camphor; Avobenzone; Triazine; Benzotriazole; Amide containing vinyl group; Cinnamic acid amide; Sulfonated benzimidazole; 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate and mixtures thereof.

6. The sunscreen formulation of claim 3, wherein the UV radiation absorber is a mixture of UV absorbers comprising: 1-(4-methoxyphenol)-3-(4-tert-butylphenyl)propane-1,3-dione; 2-ethylhexyl 2-hydroxybenzoate; 2-ethylhexyl-2-cyano-3,3-diphenyl-2-acrylate; and 3,3,5-trimethylcyclohexyl 2-hydroxybenzoate.

7. The sunscreen formulation according to claim 6, wherein the dermatologically acceptable organic carrier comprises C 1-4 Straight or branched chain alcohols.

8. The sunscreen formulation of claim 7, wherein the dermatologically acceptable organic carrier comprises ethanol.

9. The sunscreen formulation according to claim 8, further comprising a dermatologically acceptable hydrophobic ester oil.

10. A method of protecting the skin from exposure to the sun, the method comprising: Providing a sunscreen preparation according to claim 2; as well as The sunscreen formulation is applied to the skin.

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