Medicinal and edible dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing power

Abstract

The invention discloses a medicinal and edible dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing power. The invention belongs to the technical field of medicine and food. The formula comprises the following components in parts by weight: 20-30 parts of hawthorn leaves, 25-30 parts of Chinese wolfberry fruits, 30-40 parts of ginkgo leaves, 30-40 parts of black fungus, 30-40 parts of radix puerariae, 20-30 parts of lotus leaves and 30-40 parts of fiveleaf gynostemma herb. The lotus leaves are used for inhibiting fat absorption and promoting lipid metabolism, and the gynostemma pentaphylla is used for regulating blood fat and blood sugar and cooperates with the hawthorn leaves, the black fungus and other original components, so that hyperlipidemia is snipped from multiple links, and the lipid-lowering effect is more remarkable; meanwhile, the raw materials cooperate to create a good physical state, so that the self-healing potential of the body is further stimulated, and the body is assisted to resist diseases and recover health; all the raw materials are medicinal and edible, are natural and mild, have no obvious side effects, are suitable for life cultivation and health preservation or hyperlipidemia adjuvant therapy for a long time, and have huge market potential.

Description

Technical Field

[0001] The invention belongs to the technical field of medicine and food, and specifically refers to a medicine and food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability. Background Art

[0002] In today's society, with the ever-accelerating pace of life and changes in people's eating habits, the incidence of hyperlipidemia has shown an upward trend year by year. Long-term intake of high-calorie, high-fat, high-sugar foods, coupled with a serious lack of exercise, has caused lipid metabolism disorders in the body, and abnormal increases in lipid components such as cholesterol and triglycerides in the blood. According to authoritative medical statistics, the prevalence of hyperlipidemia in the adult population has exceeded 30%, becoming an invisible killer that endangers public health.

[0003] Hyperlipidemia is not just an abnormality of blood lipid indicators. The series of chain reactions it triggers seriously threaten the health of various systems in the body. Excessive blood lipids will increase blood viscosity and slow blood flow, which will cause obstruction of the microcirculation system. Microcirculation, as the terminal link of human blood circulation, is responsible for transporting oxygen and nutrients to tissue cells and taking away metabolic waste. Once microcirculation is blocked, the organs of the body cannot get enough nutrients, metabolic waste accumulates, and their functions gradually decline. For example, the cardiovascular and cerebrovascular systems are extremely susceptible to microcirculation disorders caused by hyperlipidemia. The risk of serious diseases such as coronary atherosclerosis and cerebral infarction has risen sharply, posing a huge threat to the life and health of patients.

[0004] At the same time, various stressors, environmental pollution and unhealthy lifestyles in modern life are continuously depleting the body's self-healing ability. As the body's innate self-repair and defense mechanism, self-healing ability plays a vital role in fighting diseases and maintaining physiological balance. However, people who have been in a sub-healthy state for a long time have a low self-healing ability. When faced with chronic diseases such as hyperlipidemia, the body lacks sufficient ability to self-regulate and repair.

[0005] The current treatment methods for hyperlipidemia in the market are relatively simple, mainly based on chemical synthetic drugs. Although these drugs can effectively lower blood lipid levels in the short term, they are often accompanied by many side effects, such as liver and kidney damage, rhabdomyolysis, etc., which bring additional health burdens to patients. Moreover, most of the existing lipid-lowering products focus on simply lowering blood lipid values, ignoring the improvement of the body's microcirculation and the restoration of self-healing ability. They cannot fundamentally solve the health problems of patients with hyperlipidemia and are difficult to meet people's growing pursuit of high-quality and healthy life. Summary of the invention

[0006] The purpose of the present invention is to provide a medicine and food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability. The present invention uses lotus leaves to inhibit fat absorption and promote lipid metabolism, and uses Gynostemma pentaphyllum to regulate blood lipids and blood sugar. It cooperates with original ingredients such as hawthorn leaves and black fungus to attack hyperlipidemia from multiple links, and the lipid-lowering effect is more significant; at the same time, the good physical state created by the synergistic effect of various raw materials further stimulates the body's self-healing potential, helps the body resist diseases and restore health; all raw materials are both medicine and food, natural and mild, without obvious side effects, suitable for long-term use as health care or auxiliary treatment of hyperlipidemia, and has huge market potential.

[0007] In order to achieve the above-mentioned purpose, the technical scheme adopted by the present invention is as follows: a medicine and food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability, the medicine and food dual-purpose formula comprising the following components in parts by weight: 10-50 parts of hawthorn leaves, 15-40 parts of wolfberries, 20-50 parts of ginkgo leaves, 10-50 parts of black fungus, 10-50 parts of kudzu roots, 20-50 parts of lotus leaves, and 10-45 parts of Gynostemma pentaphyllum.

[0008] Preferably, the medicine and food formula comprises the following components in parts by weight: 15-40 parts of hawthorn leaves, 20-30 parts of wolfberries, 25-40 parts of ginkgo leaves, 20-50 parts of black fungus, 20-40 parts of kudzu roots, 20-40 parts of lotus leaves, and 20-40 parts of Gynostemma pentaphyllum.

[0009] Preferably, the medicine and food formula comprises the following components in parts by weight: 20-30 parts of hawthorn leaves, 25-30 parts of wolfberries, 30-40 parts of ginkgo leaves, 30-40 parts of black fungus, 30-40 parts of kudzu roots, 20-30 parts of lotus leaves, and 30-40 parts of gynostemma pentaphyllum.

[0010] The present invention also provides a method for preparing a medicine-food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability, the preparation method comprising the following steps:

[0011] (1) Raw material pretreatment: Wash hawthorn leaves and ginkgo leaves to remove impurities; soak black fungus, wash and tear into small pieces; wash wolfberry, kudzu root and gynostemma pentaphyllum, dry and set aside; wash lotus leaves, cut into small pieces and dry;

[0012] (2) Extraction of active ingredients: using water extraction, adding appropriate amount of distilled water to the processed wolfberry, kudzu root and gynostemma pentaphyllum, heating to boiling and then keeping it in a slightly boiling state, filtering and collecting the filtrate; using ultrasound-assisted extraction for hawthorn leaves, ginkgo leaves and black fungus, using the cavitation effect of ultrasound to break up the cells, adding appropriate amount of ethanol solution as the extraction solvent, ultrasonic treatment for 30-60 minutes and filtering to obtain the extract; using alcohol extraction and water precipitation for lotus leaves, first soaking with appropriate amount of ethanol, after reflux extraction, concentrating the extract, adding appropriate amount of water, letting it stand and precipitating, and taking the supernatant;

[0013] (3) Mixing and concentration: The filtrate obtained above is combined with the extract and the supernatant, placed in a vacuum concentrator, and concentrated to 1 / 3-1 / 2 of the original volume at a temperature of 50-60° C. and a vacuum degree of 0.08-01 MPa to obtain a concentrated solution;

[0014] (4) Molding: Based on actual needs, the concentrated liquid is made into oral liquid and packaged through an aseptic filling process; or it is further dried to form a powder and filled into capsules to form capsules; or appropriate amounts of auxiliary materials can be added to form tablets to meet the taking habits of different consumers.

[0015] Preferably, the duration of the slight boiling state in step (2) is 1-2 hours.

[0016] Preferably, the conditions of the vacuum concentration device in step (3) are a temperature of 50-60° C. and a vacuum degree of 0.08-0.1 MPa.

[0017] Preferably, when preparing the oral liquid in step (4), flavoring agents such as honey or xylitol may be added.

[0018] Preferably, when preparing capsules in step (4), auxiliary materials such as microcrystalline cellulose and magnesium stearate may be added.

[0019] Preferably, when preparing tablets in step (4), auxiliary materials starch and lactose may be added.

[0020] The beneficial effects achieved by the present invention using the above structure are as follows: (1) The present invention uses lotus leaves to inhibit fat absorption and promote lipid metabolism, and Gynostemma pentaphyllum regulates blood lipids and blood sugar, and cooperates with original ingredients such as hawthorn leaves and black fungus to attack hyperlipidemia from multiple links, and the lipid-lowering effect is more significant; (2) The good physical state created by the synergistic effects of the various raw materials in the present invention further stimulates the body's self-healing potential, helps the body resist diseases and restore health; (3) All raw materials used in the present invention are both medicinal and edible, natural and mild, without obvious side effects, and are suitable for long-term use as health care or auxiliary treatment of hyperlipidemia, and have huge market potential.

[0021] The present invention uses natural medicinal and edible raw materials as the main ingredients to play the role of reducing hyperlipidemia, improving microcirculation and repairing self-healing power. Among them, hawthorn leaves are rich in nutrients such as various organic acids and vitamin C, which can help digestion and invigorate the stomach. In particular, the flavonoids therein can effectively reduce blood lipids, dilate blood vessels, and improve microcirculation; wolfberry has the effects of nourishing the liver and kidneys and improving vision. The active ingredients such as wolfberry polysaccharides contained therein can, on the one hand, regulate blood lipid metabolism, and on the other hand, can enhance the body's immunity and help improve the body's self-healing power; ginkgo leaves have a strong antioxidant effect, which can inhibit platelet aggregation, reduce blood viscosity, thereby promoting blood circulation, and have a significant effect on improving microcirculation disorders. At the same time, it helps to reduce vascular endothelial damage and create favorable conditions for reducing blood lipids; black fungus is rich in dietary fiber, which can absorb excess cholesterol in the intestine and excrete it from the body, directly reducing blood lipid levels, and its iron content is relatively high, which can improve anemia and provide sufficient oxygen for various tissues and organs of the body , ensuring the smooth operation of microcirculation, which is beneficial to the recovery of body functions and the strengthening of self-healing ability; isoflavone compounds such as puerarin in Pueraria root can not only dilate coronary arteries and cerebral blood vessels, increase coronary blood flow and cerebral blood flow, and improve heart and brain microcirculation, but also have the effects of lowering blood lipids and resisting thrombosis, protecting cardiovascular health in all directions, and synergistically improving the body's self-repair ability; lotus leaves contain ingredients such as nelumbo nucifera, which have significant lipid-lowering and weight-loss effects, can inhibit lipase activity, reduce fat absorption, and at the same time promote lipid metabolism in the body, synergistically with other raw materials to further enhance the lipid-lowering effect, and lotus leaves have the functions of clearing away heat and relieving summer heat, and promoting the clear yang, which helps to regulate the overall function of the body; Gynostemma pentaphyllum is rich in a variety of ginsenosides, which have a nourishing and strengthening effect similar to ginseng, can regulate the body's immunity, enhance the body's self-healing ability, and can effectively lower blood lipids, regulate blood sugar, improve blood viscosity, and have a positive auxiliary effect on the improvement of microcirculation, complementing other ingredients in the formula. BRIEF DESCRIPTION OF THE DRAWINGS

[0022] Figure 1 TG levels in rat serum.

[0023] The accompanying drawings are used to provide further understanding of the present invention and constitute a part of the specification. They are used to explain the present invention together with the embodiments of the present invention and do not constitute a limitation of the present invention. DETAILED DESCRIPTION

[0024] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments; based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0025] Unless otherwise defined, all professional and scientific terms used herein have the same meanings as those familiar to those skilled in the art. In addition, any methods and materials similar or equivalent to those described herein may be applied to the present invention. The preferred implementation methods and materials described herein are for demonstration purposes only and are not intended to limit the content of this application.

[0026] The experimental methods in the following examples are conventional methods unless otherwise specified; the experimental materials and test strains used in the following examples are purchased from commercial channels unless otherwise specified.

[0027] Example 1

[0028] A medicine and food formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability

[0029] The medicine and food formula comprises the following components in parts by weight: 20 parts of hawthorn leaves, 30 parts of wolfberries, 30 parts of ginkgo leaves, 40 parts of black fungus, 30 parts of kudzu roots, 30 parts of lotus leaves, and 30 parts of gynostemma pentaphyllum.

[0030] The present invention also provides a method for preparing a medicine-food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability, the preparation method comprising the following steps:

[0031] (1) Raw material pretreatment: Wash hawthorn leaves and ginkgo leaves to remove impurities; soak black fungus, wash and tear into small pieces; wash wolfberry, kudzu root and gynostemma pentaphyllum, dry and set aside; wash lotus leaves, cut into small pieces and dry;

[0032] (2) Extraction of active ingredients: using water extraction, adding appropriate amount of distilled water to the processed wolfberry, kudzu root and gynostemma pentaphyllum, heating to boiling and then keeping it in a slightly boiling state, filtering and collecting the filtrate; using ultrasound-assisted extraction for hawthorn leaves, ginkgo leaves and black fungus, using the cavitation effect of ultrasound to break up the cells, adding appropriate amount of ethanol solution as the extraction solvent, ultrasonic treatment for 30-60 minutes and filtering to obtain the extract; using alcohol extraction and water precipitation for lotus leaves, first soaking with appropriate amount of ethanol, after reflux extraction, concentrating the extract, adding appropriate amount of water, letting it stand and precipitating, and taking the supernatant;

[0033] (3) Mixing and concentration: The filtrate obtained above is combined with the extract and the supernatant, placed in a vacuum concentrator, and concentrated to 1 / 3-1 / 2 of the original volume at a temperature of 50-60° C. and a vacuum degree of 0.08-01 MPa to obtain a concentrated solution;

[0034] (4) Molding: Based on actual needs, the concentrated liquid is made into oral liquid and packaged through an aseptic filling process; or it is further dried to form a powder and filled into capsules to form capsules; or appropriate amounts of auxiliary materials can be added to form tablets to meet the taking habits of different consumers.

[0035] Wherein, the duration of the slight boiling state in step (2) is 1-2 hours.

[0036] The conditions of the vacuum concentration device in step (3) are a temperature of 50-60°C and a vacuum degree of 0.08-0.1 MPa.

[0037] Wherein, when preparing the oral liquid in step (4), flavoring agents honey and xylitol are added.

[0038] Wherein, when preparing capsules in step (4), auxiliary materials microcrystalline cellulose and magnesium stearate are added.

[0039] Wherein, when preparing tablets in step (4), auxiliary materials starch and lactose are added.

[0040] Example 2

[0041] A medicine and food formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability

[0042] The medicine and food formula comprises the following components in parts by weight: 30 parts of hawthorn leaves, 25 parts of wolfberries, 40 parts of ginkgo leaves, 30 parts of black fungus, 40 parts of kudzu roots, 20 parts of lotus leaves, and 40 parts of gynostemma pentaphyllum.

[0043] The present invention also provides a method for preparing a medicine-food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability. The preparation method is implemented with reference to Example 1.

[0044] Example 3

[0045] A medicine and food formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability

[0046] The medicine and food formula comprises the following components in parts by weight: 25 parts of hawthorn leaves, 28 parts of wolfberries, 35 parts of ginkgo leaves, 35 parts of black fungus, 35 parts of kudzu roots, 25 parts of lotus leaves, and 35 parts of gynostemma pentaphyllum.

[0047] The present invention also provides a method for preparing a medicine-food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability. The preparation method is implemented with reference to Example 1.

[0048] Experimental Example 1

[0049] Effect of a medicine-food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability on TG levels

[0050] 60 healthy male SD rats weighing between 200-250g were selected for the experiment after adaptive feeding for 1 week, and randomly divided into three groups, each with 20 rats, recorded as Example 1 group, Example 2 group and Example 3 group. Each group was given the oral solution of the formula of the present invention, according to gavage once a day for each rat for 3 months; before the start of the experiment and 3 months after the administration, blood was collected from the retro-orbital venous plexus of the rats in each group, and the TG level in the serum was detected using a fully automatic biochemical analyzer and a corresponding kit.

[0051] Result analysis: Figure 1 As shown, the serum TG content of mice in Example 1-3 groups was at a relatively high level, among which the TG in Example 3 group was the highest, followed by Example 1 group and Example 2 group.

[0052] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

[0053] The present invention and its embodiments are described above, and such description is not restrictive. The drawings show only one embodiment of the present invention, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design a structure and embodiment similar to the technical solution without creativity, which should belong to the protection scope of the present invention.

Claims

1. A medicine and food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability, characterized by: The medicine and food formula comprises the following components in parts by weight: 10-50 parts of hawthorn leaves, 15-40 parts of wolfberries, 20-50 parts of ginkgo leaves, 10-50 parts of black fungus, 10-50 parts of kudzu roots, 20-50 parts of lotus leaves, and 10-45 parts of gynostemma pentaphyllum.

2. A medicine and food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability according to claim 1, characterized in that: The medicine and food formula comprises the following components in parts by weight: 15-40 parts of hawthorn leaves, 20-30 parts of wolfberries, 25-40 parts of ginkgo leaves, 20-50 parts of black fungus, 20-40 parts of kudzu roots, 20-40 parts of lotus leaves, and 20-40 parts of gynostemma pentaphyllum.

3. A medicine and food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability according to claim 2, characterized in that: The medicine and food formula comprises the following components in parts by weight: 20-30 parts of hawthorn leaves, 25-30 parts of wolfberries, 30-40 parts of ginkgo leaves, 30-40 parts of black fungus, 30-40 parts of kudzu roots, 20-30 parts of lotus leaves, and 30-40 parts of gynostemma pentaphyllum.

4. A method for preparing the medicine-food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability according to claim 3, characterized in that: The preparation method comprises the following steps: (1) Raw material pretreatment: Wash hawthorn leaves and ginkgo leaves to remove impurities; soak black fungus, wash and tear into small pieces; wash wolfberry, kudzu root and gynostemma pentaphyllum, dry and set aside; wash lotus leaves, cut into small pieces and dry; (2) Extraction of active ingredients: using water extraction, adding appropriate amount of distilled water to the processed wolfberry, kudzu root and gynostemma pentaphyllum, heating to boiling and then keeping it in a slightly boiling state, filtering and collecting the filtrate; using ultrasound-assisted extraction for hawthorn leaves, ginkgo leaves and black fungus, using the cavitation effect of ultrasound to break up the cells, adding appropriate amount of ethanol solution as the extraction solvent, ultrasonic treatment for 30-60 minutes and filtering to obtain the extract; using alcohol extraction and water precipitation for lotus leaves, first soaking with appropriate amount of ethanol, after reflux extraction, concentrating the extract, adding appropriate amount of water, letting it stand and precipitating, and taking the supernatant; (3) Mixing and concentration: The filtrate obtained above is combined with the extract and the supernatant, placed in a vacuum concentrator, and concentrated to 1 / 3-1 / 2 of the original volume at a temperature of 50-60° C. and a vacuum degree of 0.08-01 MPa to obtain a concentrated solution; (4) Molding: Based on actual needs, the concentrated liquid is made into oral liquid and packaged through an aseptic filling process; or it is further dried to form a powder and filled into capsules to form capsules; or appropriate amounts of auxiliary materials can be added to form tablets to meet the taking habits of different consumers.

5. The method for preparing a medicine-food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability according to claim 4, characterized in that: The duration of the slight boiling state in step (2) is 1-2 hours.

6. The method for preparing a medicine-food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability according to claim 5, characterized in that: The conditions of the vacuum concentration device in step (3) are a temperature of 50-60° C. and a vacuum degree of 0.08-0.1 MPa.

7. The method for preparing a medicine-food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability according to claim 6, characterized in that: When preparing the oral liquid in step (4), flavoring agents such as honey or xylitol may be added.

8. The method for preparing a medicine-food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability according to claim 7, characterized in that: When preparing capsules in step (4), auxiliary materials such as microcrystalline cellulose and magnesium stearate may be added.

9. The method for preparing a medicine-food dual-purpose formula for reducing hyperlipidemia, improving microcirculation and repairing self-healing ability according to claim 8, characterized in that: When preparing tablets in step (4), auxiliary materials such as starch and lactose may be added.

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