Device for sonodynamic treatment of brain glioma

Abstract

The invention relates to the technical field of sonodynamic therapy, in particular to a device for sonodynamic treatment of brain glioma, which is provided with an image guiding module, a treatment planning module, an ultrasonic driving module, an ultrasonic mechanism and a fixing module, and is characterized in that ultrasonic energy required by different positions for sonodynamic treatment of brain glioma is calculated through the treatment planning module; and correcting the theoretical energy value according to the actually measured energy. In the application, ultrasonic irradiation is performed on the head part through image guidance, and the energy emitted by the ultrasonic waves is adaptively adjusted according to different irradiation positions, so that the safety and effectiveness of treatment are ensured.

Description

Technical Field

[0001] The invention relates to the technical field of sonodynamic therapy, and in particular to a device for sonodynamic therapy of brain glioma. Background Art

[0002] Gliomas are the most common central nervous system tumors in neurosurgery, accounting for about 46% of intracranial tumors. At present, the mainstream clinical treatments for gliomas include radiotherapy, chemotherapy and surgery, but all of them have certain defects. Among them, surgery is the most important means of treating gliomas, but surgery usually cannot completely remove the tumor, and radiotherapy and chemotherapy are needed for combined treatment. However, radiotherapy and chemotherapy use radiation or chemical drugs to kill tumor cells and inhibit tumor growth. Their treatment targeting is poor. While killing tumor cells, they also cause serious damage to normal cells, and repeated treatments cannot be performed in the short term. Therefore, there is a need for a non-invasive or minimally invasive, repeatable treatment device for gliomas that can maintain brain structure and function to the greatest extent while killing glioma cells. Summary of the invention

[0003] In view of this, an object of the present invention is to provide a device for sonodynamic treatment of brain gliomas to overcome the problems existing in the current prior art.

[0004] To achieve the above objectives, the present invention adopts the following technical solutions:

[0005] The present application provides a device for sonodynamic treatment of brain glioma, comprising: an image guidance module, a treatment planning module, an ultrasonic driving module, an ultrasonic mechanism for performing ultrasonic treatment on a patient, and a fixing module for fixing the ultrasonic mechanism on the head;

[0006] The image guidance module is connected to the treatment planning module, the treatment planning module is connected to the ultrasonic driving module through a serial port or a CAN bus, the ultrasonic driving module is connected to the ultrasonic mechanism, and the ultrasonic mechanism is fixed on the fixing module;

[0007] The image guidance module is used to receive a head image of a patient, register the head image, reconstruct a three-dimensional image of the patient's head, and obtain the Heinz value of each voxel point in the three-dimensional image;

[0008] The treatment planning module is used to calculate the sound velocity and sound attenuation coefficient of each part of the skull and brain tissue according to the Heinz value of each voxel point in the three-dimensional image, and adaptively adjust the emission energy of the ultrasonic mechanism according to the sound velocity and the sound attenuation coefficient;

[0009] The ultrasonic driving module is used to drive the ultrasonic mechanism according to the adjusted emission energy;

[0010] The ultrasonic mechanism is used to emit ultrasonic energy;

[0011] The fixing module is used to fix the ultrasonic mechanism so that the ultrasonic energy irradiates the target area, causing the sonosensitizer enriched in the target area to produce substances such as active oxygen, thereby killing tumor cells.

[0012] Furthermore, in the above-mentioned device, the image guidance module receives a head image of a patient who has been intravenously injected with a sonosensitizer for more than 24 hours; wherein the sonosensitizer can generate reactive oxygen species under the action of ultrasound.

[0013] Furthermore, in the above-mentioned device, the head image includes: an MRI head image of the patient and a CT head image of the patient.

[0014] Furthermore, in the above-mentioned device, the ultrasonic mechanism is composed of ultrasonic array elements composed of multiple piezoelectric ceramic materials, and ultrasonic waves of different energy levels are generated by exciting different piezoelectric ceramic materials with electrical signals of different sizes.

[0015] Furthermore, in the above-mentioned device, the treatment planning module includes: an ultrasound energy theoretical calculation unit and an energy comparison correction unit;

[0016] The ultrasonic energy theoretical calculation unit is used to calculate the sound velocity and sound attenuation coefficient of each part of the skull and brain tissue according to the Heinz value of each voxel point in the three-dimensional image, determine the treatment target area according to the image guidance module, determine the position of the ultrasonic mechanism according to the fixing module, determine the sound propagation path of each of the ultrasonic array elements according to the treatment target area and the position of the ultrasonic mechanism, and determine the energy attenuation parameter of the sound propagation path according to the sound propagation path, the sound velocity and sound attenuation coefficient of each part of the skull and brain tissue, calculate the remaining energy of a single ultrasonic array element according to the energy attenuation parameter, and calculate the theoretical value of the energy required for the target area according to the sound field superposition principle;

[0017] The energy comparison and correction unit is used to perform actual sound field measurement through a hydrophone to obtain an actually measured energy value, correct the theoretical value according to the actually measured energy value, and determine the emission energy according to the corrected theoretical value.

[0018] The beneficial effects of the present invention are:

[0019] The present application has an image guidance module, a treatment plan module, an ultrasonic drive module, an ultrasonic mechanism for performing ultrasonic treatment on a patient, and a fixed module in which the ultrasonic mechanism is fixed to the head. The image guidance module is connected to the treatment plan module, the treatment plan module is connected to the ultrasonic drive module via a serial port or a CAN bus, the ultrasonic drive module is connected to the ultrasonic mechanism, the ultrasonic mechanism is fixed on the fixed module, the patient's head image is received through the image guidance module, the head image is registered, the patient's head three-dimensional image is reconstructed, and the Heinz value of each voxel point in the three-dimensional image is obtained, the sound velocity and the acoustic attenuation coefficient of each part of the skull and brain tissue are calculated according to the Heinz value of each voxel point in the three-dimensional image through the treatment plan module, and the emission energy of the ultrasonic mechanism is adaptively adjusted according to the sound velocity and the acoustic attenuation coefficient, the ultrasonic mechanism is driven according to the adjusted emission energy through the ultrasonic drive module, the ultrasonic energy is emitted through the ultrasonic mechanism, the ultrasonic mechanism is fixed through the fixed module, and the ultrasonic energy is ultrasonically irradiated to the target area, so that the sonosensitizer enriched in the target area produces substances such as reactive oxygen, thereby killing tumor cells. In the present application, the treatment plan module can adaptively adjust the emission energy of each ultrasonic array in the ultrasonic mechanism according to the position of the target area and the ultrasonic mechanism. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying creative work.

[0021] Figure 1 It is a structural schematic diagram provided by an embodiment of a device for sonodynamic treatment of brain gliomas of the present invention. DETAILED DESCRIPTION

[0022] To make the purpose, technical solution and advantages of the present invention clearer, the technical solution of the present invention will be described in detail below. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other implementation methods obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention.

[0023] The present invention also provides a device for sonodynamic treatment of brain glioma, which is used to implement the above method embodiment. Figure 1 FIG. 1 is a schematic diagram of a structure of an embodiment of a device for sonodynamic treatment of brain glioma provided by the present invention. Figure 1 As shown, this embodiment includes:

[0024] An image guidance module 1, a treatment planning module 2, an ultrasonic driving module 3, an ultrasonic mechanism 4 for performing ultrasonic treatment on a patient, and a fixing module 5 for fixing the ultrasonic mechanism 4 on the head;

[0025] The image guidance module 1 is connected to the treatment planning module 2, the treatment planning module 2 is connected to the ultrasonic driving module 3 through a serial port or a CAN bus, the ultrasonic driving module 3 is connected to the ultrasonic mechanism 4, and the ultrasonic mechanism 4 is fixed on the fixing module 5;

[0026] The image guidance module 1 is used to receive the patient's head image, register the head image, reconstruct the patient's head three-dimensional image, and obtain the Heinz value of each voxel point in the three-dimensional image;

[0027] The treatment planning module 2 is used to calculate the sound velocity and sound attenuation coefficient of each part of the skull and brain tissue according to the Heinz value of each voxel point in the three-dimensional image, and adaptively adjust the emission energy of the ultrasonic mechanism 4 according to the sound velocity and sound attenuation coefficient;

[0028] An ultrasonic driving module 3, used to drive the ultrasonic mechanism 4 according to the adjusted transmission energy;

[0029] Ultrasonic mechanism 4, used for emitting ultrasonic energy;

[0030] The fixing module 5 is used to fix the ultrasonic mechanism 4 so that the ultrasonic energy irradiates the target area, causing the sonosensitizer enriched in the target area to produce substances such as active oxygen, thereby killing tumor cells.

[0031] Preferably, the image guidance module 1 receives a head image of a patient who has been intravenously injected with a sonosensitizer for more than 24 hours; wherein the sonosensitizer can generate active oxygen species under the action of ultrasound.

[0032] It is understandable that for patients with brain glioma, a sonosensitizer that can produce reactive oxygen species under the action of ultrasound is injected intravenously and waited for more than 24 hours to circulate in the body so that the sonosensitizer can be enriched near the tumor.

[0033] Preferably, the head image includes: an MRI head image of the patient and a CT head image of the patient.

[0034] Preferably, the ultrasonic mechanism 4 is composed of a plurality of ultrasonic array elements composed of piezoelectric ceramic materials, and generates ultrasonic waves of different energy levels by exciting different piezoelectric ceramic materials with electric signals of different sizes.

[0035] It can be understood that the image guidance module 1 is connected to the treatment planning module 2, and the image guidance module 1 includes the import of head MRI and CT images, MRI and CT image registration, head three-dimensional reconstruction and acquisition of the Heinz value H of each voxel point in the three-dimensional image; the treatment planning module 2 is connected and communicated with the ultrasonic driving module 3 through a serial port or a CAN bus, and the treatment planning module 2 includes calculating the sound velocity and acoustic attenuation coefficient of each part of the skull and brain tissue according to the Heinz value H of each voxel point in the three-dimensional skull reconstruction image, and adaptively adjusting the emission energy of the ultrasonic mechanism 4 for treating the patient according to the above acoustic parameters; the ultrasonic driving module 3 is connected and communicated with the patient through the serial port or the CAN bus. The ultrasonic mechanism 4 is connected to the patient, and the ultrasonic emission energy is calculated by the treatment plan module 2 to drive the ultrasonic mechanism 4 for ultrasonic treatment of the patient; the ultrasonic mechanism 4 for ultrasonic treatment of the patient is fixed to the patient's head by a fixing module 5 that fixes the ultrasonic mechanism 4 to the head. The ultrasonic mechanism 4 for ultrasonic treatment of the patient mainly includes an array composed of multiple piezoelectric ceramic materials, and different piezoelectric ceramic materials are stimulated by electrical signals of different sizes to generate ultrasonic waves of different energy sizes; the fixing module 5 that fixes the ultrasonic mechanism 4 to the head includes a fixing device that adapts to the shape of the head, and is used to fix the ultrasonic mechanism 4 for ultrasonic treatment of the patient.

[0036] Preferably, the treatment planning module 2 comprises: an ultrasound energy theoretical calculation unit and an energy comparison correction unit;

[0037] An ultrasonic energy theoretical calculation unit, used to calculate the sound velocity and acoustic attenuation coefficient of each part of the skull and brain tissue according to the Heinz value of each voxel point in the three-dimensional image, determine the treatment target area according to the image guidance module 1, determine the position of the ultrasonic mechanism 4 according to the fixing module 5, determine the acoustic propagation path of each ultrasonic array element according to the treatment target area and the position of the ultrasonic mechanism 4, and determine the energy attenuation parameter of the acoustic propagation path according to the acoustic propagation path, the sound velocity and acoustic attenuation coefficient of each part of the skull and brain tissue, calculate the remaining energy of a single ultrasonic array element according to the energy attenuation parameter, and calculate the theoretical value of the energy required for the target area according to the principle of sound field superposition;

[0038] The energy comparison and correction unit is used to obtain the actual measured energy value by measuring the actual sound field through the hydrophone, correct the theoretical value according to the actual measured energy value, and determine the emission energy according to the corrected theoretical value.

[0039] It can be understood that the same or similar parts of the above embodiments can be referenced to each other, and the contents not described in detail in some embodiments can refer to the same or similar contents in other embodiments.

[0040] It should be noted that, in the description of the present invention, the terms "first", "second", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance. In addition, in the description of the present invention, unless otherwise specified, the meaning of "plurality" refers to at least two.

[0041] Any process or method description in a flowchart or otherwise described herein may be understood to represent a module, segment or portion of code that includes one or more executable instructions for implementing the steps of a specific logical function or process, and the scope of the preferred embodiments of the present invention includes alternative implementations in which functions may not be performed in the order shown or discussed, including performing functions in a substantially simultaneous manner or in the reverse order depending on the functions involved, which should be understood by those skilled in the art to which the embodiments of the present invention belong.

[0042] It should be understood that the various parts of the present invention can be implemented by hardware, software, firmware or a combination thereof. In the above-mentioned embodiments, a plurality of steps or methods can be implemented by software or firmware stored in a memory and executed by a suitable instruction execution system. For example, if implemented by hardware, as in another embodiment, it can be implemented by any one of the following technologies known in the art or their combination: a discrete logic circuit having a logic gate circuit for implementing a logic function for a data signal, a dedicated integrated circuit having a suitable combination of logic gate circuits, a programmable gate array (PGA), a field programmable gate array (FPGA), etc.

[0043] A person skilled in the art may understand that all or part of the steps in the method for implementing the above-mentioned embodiment may be completed by instructing related hardware through a program, and the program may be stored in a computer-readable storage medium, which, when executed, includes one or a combination of the steps of the method embodiment.

[0044] In addition, each functional unit in each embodiment of the present invention may be integrated into a processing module, or each unit may exist physically separately, or two or more units may be integrated into one module. The above-mentioned integrated module may be implemented in the form of hardware or in the form of a software functional module. If the integrated module is implemented in the form of a software functional module and sold or used as an independent product, it may also be stored in a computer-readable storage medium.

[0045] The storage medium mentioned above can be a read-only memory, a magnetic disk or an optical disk, etc.

[0046] In the description of this specification, the description with reference to the terms "one embodiment", "some embodiments", "examples", "specific examples", or "some examples" means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described may be combined in any one or more embodiments or examples in a suitable manner.

[0047] Although the embodiments of the present invention have been shown and described above, it is to be understood that the above embodiments are exemplary and are not to be construed as limitations of the present invention. A person skilled in the art may change, modify, replace and vary the above embodiments within the scope of the present invention.

Claims

1. A device for sonodynamic treatment of brain glioma, characterized in that: include: An image guidance module, a treatment planning module, an ultrasonic driving module, an ultrasonic mechanism for performing ultrasonic treatment on a patient, and a fixing module for fixing the ultrasonic mechanism on the head; The image guidance module is connected to the treatment planning module, the treatment planning module is connected to the ultrasonic driving module through a serial port or a CAN bus, the ultrasonic driving module is connected to the ultrasonic mechanism, and the ultrasonic mechanism is fixed on the fixing module; The image guidance module is used to receive a head image of a patient, register the head image, reconstruct a three-dimensional image of the patient's head, and obtain the Heinz value of each voxel point in the three-dimensional image; The treatment planning module is used to calculate the sound velocity and sound attenuation coefficient of each part of the skull and brain tissue according to the Heinz value of each voxel point in the three-dimensional image, and adaptively adjust the emission energy of the ultrasonic mechanism according to the sound velocity and the sound attenuation coefficient; The ultrasonic driving module is used to drive the ultrasonic mechanism according to the adjusted emission energy; The ultrasonic mechanism is used to emit ultrasonic energy; The fixing module is used to fix the ultrasonic mechanism so that the ultrasonic energy irradiates the target area, causing the sonosensitizer enriched in the target area to produce substances such as active oxygen, thereby killing tumor cells.

2. The device according to claim 1, characterized in that The image guidance module receives a head image of a patient who has been intravenously injected with a sonosensitizer for more than 24 hours; wherein the sonosensitizer can generate active oxygen species under the action of ultrasound.

3. The device according to claim 2, characterized in that The head image includes: an MRI head image of the patient and a CT head image of the patient.

4. The device according to claim 1, characterized in that The ultrasonic mechanism is composed of ultrasonic array elements composed of a plurality of piezoelectric ceramic materials, and generates ultrasonic waves of different energy levels by exciting different piezoelectric ceramic materials with electric signals of different sizes.

5. The device according to claim 1, characterized in that The treatment plan module includes: an ultrasound energy theoretical calculation unit and an energy comparison correction unit; The ultrasonic energy theoretical calculation unit is used to calculate the sound velocity and sound attenuation coefficient of each part of the skull and brain tissue according to the Heinz value of each voxel point in the three-dimensional image, determine the treatment target area according to the image guidance module, determine the position of the ultrasonic mechanism according to the fixing module, determine the sound propagation path of each of the ultrasonic array elements according to the treatment target area and the position of the ultrasonic mechanism, and determine the energy attenuation parameter of the sound propagation path according to the sound propagation path, the sound velocity and sound attenuation coefficient of each part of the skull and brain tissue, calculate the remaining energy of a single ultrasonic array element according to the energy attenuation parameter, and calculate the theoretical value of the energy required for the target area according to the sound field superposition principle; The energy comparison and correction unit is used to perform actual sound field measurement through a hydrophone to obtain an actually measured energy value, correct the theoretical value according to the actually measured energy value, and determine the emission energy according to the corrected theoretical value.

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