Cosmetic containing rhodiola rosea extract and preparation method thereof

Abstract

The invention relates to the field of cosmetics, in particular to a cosmetic containing a rhodiola rosea extract and a preparation method of the cosmetic. The cosmetic containing the rhodiola rosea extract is prepared from the following components in parts by weight: 0.3 to 0.5 part of radix et rhizoma rhei, 0.4 to 0.8 part of rosavin, 0.1 to 1.5 parts of ascorbic acid, 4 to 8 parts of glycerinum, 0.5 to 3 parts of sodium hyaluronate, 3 to 6 parts of grape seed oil, 2 to 4 parts of camellia oil, 1 to 2 parts of xanthan gum, 1 to 2 parts of carbomer and 90 parts of deionized water. Through the synergistic effect of collateral and rosavin, keratinocytes are effectively removed, and synthesis of melanin is mildly inhibited. According to the formula design, the skin care effect is guaranteed, and the possible skin injury risk is reduced.

Description

Technical Field

[0001] The present application relates to the field of cosmetics, and in particular to a cosmetic containing a Rhodiola rosea extract and a preparation method thereof. Background Art

[0002] Whitening cosmetics have developed over the years, from the initial simple physical covering and whitening to the exfoliation of the stratum corneum, and then to the synergistic whitening under the action of various whitening ingredients. Each stage of development is a technological innovation.

[0003] At present, whitening technology often uses low concentrations of α-hydroxy acids to promote the shedding of keratinocytes and renew basal cells, thereby reshaping the epidermis and reducing pigmentation. With the deepening of whitening cosmetic research, consumers have new demands for whitening cosmetics, advocating natural beauty rather than simply whitening, and wanting to whiten the skin while maintaining skin health, and supplementing the skin with nutrients while pursuing whitening.

[0004] Therefore, most R&D personnel began to add crude plant extracts to cosmetics to achieve healthy whitening effects. However, crude plant extracts are complex and contain a variety of substances, which may antagonize each other. Some crude plant extracts even antagonize other conventional ingredients in cosmetics, making it difficult for cosmetics containing crude plant extracts to meet people's healthy whitening needs. Summary of the invention

[0005] In order to solve the problem that cosmetics containing crude plant extracts are difficult to meet people's healthy whitening needs, the present application provides a cosmetic containing Rhodiola rosea extract, which effectively removes keratinocytes and gently inhibits the synthesis of melanin through the synergistic effect of rosa cannabinoids and rosavirin. This formula design not only ensures the skin care effect, but also reduces the risk of possible skin damage.

[0006] In a first aspect, the present application provides a cosmetic containing a Rhodiola rosea extract, using the following technical solution: A cosmetic containing a rhodiola rosea extract comprises the following components in parts by weight: 0.3-0.5 parts of chorion, 0.4-0.8 parts of rosavitin, 0.1-1.5 parts of ascorbic acid, 4-8 parts of glycerol, 0.5-3 parts of sodium hyaluronate, 3-6 parts of grape seed oil, 2-4 parts of camellia oil, 1-2 parts of xanthan gum, 1-2 parts of carbomer and 90 parts of deionized water.

[0007] By adopting the above technical solution, chorion has a strong and effective effect on removing keratinocytes and inhibiting melanin synthesis. However, when the concentration of chorion is too high, it will seriously damage the stratum corneum of the skin and easily cause symptoms such as inflammation. Rosavi is relatively gentle in the process of removing keratinocytes and inhibiting melanin synthesis, which also leads to its low effect on removing keratinocytes and inhibiting melanin synthesis.

[0008] When chloranil and rosavi are compounded according to the above formula, chloranil first exerts its powerful ability to remove keratinocytes, effectively reducing the thickness of the stratum corneum and creating conditions for the subsequent penetration of skin care ingredients. And at this time, the concentration of chloranil is low, avoiding excessive damage to the stratum corneum of the skin. After the action of chloranil, rosavi then takes effect. Due to its slower but gentler removal efficiency, rosavi can further remove those keratinocytes that have been treated by chloranil and may have been damaged. This step-by-step, synergistic mode of action not only ensures the effect of removing keratinocytes, but also avoids the skin damage that may be caused by a single high-concentration ingredient. Similarly, rosavi has the function of inhibiting melanin synthesis while removing keratinocytes. Although its effect is not as significant as chloranil, further inhibiting melanin on the basis of chloranil helps to improve the overall whitening effect.

[0009] The present invention not only effectively removes keratinocytes but also mildly inhibits the synthesis of melanin through the synergistic effect of rosin and rosavirin. This formula design not only ensures the skin care effect but also reduces the risk of possible skin damage.

[0010] Preferably, the mass ratio of the plexiglass to the plexiglass is 0.4:0.5-0.7.

[0011] By adopting the above technical solution, in the cosmetic formula, Rosavin and L-Citrin work synergistically. After L-Citrin removes keratinocytes, Rosavin can further remove damaged keratinocytes and inhibit melanin. If the content of Rosavin is too low, it may not be able to fully exert its synergistic effect with L-Citrin, affecting the overall skin care efficiency and effect.

[0012] Although the removal efficiency of Rosavi is slow and gentle, it is still possible to cause unnecessary irritation to the skin if the content is too high. This may cause adverse reactions such as skin redness, swelling, and sensitivity, thus affecting the user's experience.

[0013] Preferably, the cosmetic containing Rhodiola rosea extract further comprises a carboxyl-containing polymer.

[0014] By adopting the above technical scheme, the chelate and rosabi contain a large number of hydroxyl groups (-OH), while the carboxyl-containing polymer has carboxyl groups (-COOH). Under appropriate conditions, the hydroxyl and carboxyl groups can undergo chemical reactions, such as esterification, to form ester bonds. This chemical reaction connects multiple chelate or rosabi molecules with polymer molecules to form a network structure.

[0015] Compared with individual chelators and rosavidin molecules, this network structure is more stable because it not only increases the interaction between molecules, but also reduces the freedom of individual molecules when heated. When heated, the molecules in the network structure need to overcome more energy to decompose or move, thereby improving the overall thermal stability of the material.

[0016] The low thermal stability of chorion and rosavir limits their widespread use in cosmetics. However, by reacting with carboxyl-containing polymers to form a network structure, their thermal stability can be significantly improved. This means that during the production, storage and use of cosmetics, the ingredients of chorion and rosavir can remain more stable, reducing decomposition and failure caused by heat.

[0017] Preferably, the carboxyl-containing polymer includes at least one of polymaleic acid, polyacrylic acid, and polyaspartic acid.

[0018] By adopting the above technical solution, polymaleic acid is a polymer compound containing multiple carboxyl groups, which has good water solubility and chemical stability. Its carboxyl group can react with the hydroxyl group in the chelate and rosavidin molecules to form a stable ester bond, thereby connecting multiple active molecules into a network structure, improving the thermal stability and chemical stability of the entire system. Polymaleic acid also has excellent dispersibility and chelating properties, which can help other ingredients in cosmetics to be better dispersed and stabilized, and improve the use effect of the product.

[0019] Polyacrylic acid is also a high molecular polymer that contains a large number of carboxyl groups and has good water solubility and biocompatibility. It can react with the hydroxyl groups of chorion and rosavidin to enhance the interaction of active ingredients in cosmetic formulas, form a stable network structure, and improve the overall performance of the product. Polyacrylic acid also has excellent thickening and adhesion properties, which can improve the texture and application feel of cosmetics and make the product easier to be absorbed by the skin.

[0020] Polyaspartic acid is an environmentally friendly polymer material, which is formed by polymerization of aspartic acid monomers. Its molecular chain contains multiple carboxyl groups and other polar groups. Its carboxyl groups can react with chorion and rosavidin to form stable chemical bonds, thus improving the thermal and chemical stability of the product. Polyaspartic acid also has good biodegradability and biocompatibility, is mild and non-irritating to the skin, and is suitable for use in cosmetics and other personal care related products.

[0021] Preferably, the mass ratio of the chelate to the polymaleic acid is 4:0.2-0.4.

[0022] By adopting the above technical solution, polymaleic acid reacts with the hydroxyl groups in the complex molecules to form stable chemical bonds, thereby significantly improving the thermal stability of the complex. If the quality of the polymaleic acid is lower, that is, its content is reduced, the number of carboxyl groups that can participate in the reaction will also be reduced accordingly. This will result in insufficient polymaleic acid molecules combined with the complex, and it will be impossible to form enough cross-linking points to stabilize the entire network structure. Therefore, the complex molecules are more likely to decompose or structurally damage when heated, thereby reducing the effect of improving thermal stability.

[0023] When the mass of polymaleic acid is too high, that is, its content increases, although it can provide more carboxyl groups to react with the chelate, it will also cause the formed cross-linked network to be too tight. In this highly cross-linked network, the relative position between the chelate and rosavidin molecules may be restricted, so that the synergistic effect between them is disturbed. Specifically, the role of rosavidin in removing damaged keratinocytes and inhibiting melanin synthesis may require a certain degree of spatial freedom to play, and an over-cross-linked network may limit this degree of freedom.

[0024] Preferably, the mass ratio of the chelate to the polyacrylic acid is 4:0.4-0.6.

[0025] By adopting the above technical solution, polyacrylic acid reacts with the hydroxyl groups in the complex molecules to form stable chemical bonds, thereby significantly improving the thermal stability of the complex. If the mass of polyacrylic acid is lower, that is, its content is reduced, the number of carboxyl groups that can participate in the reaction will also be reduced accordingly. This will result in insufficient polyacrylic acid molecules combined with the complex, and it will be impossible to form enough cross-linking points to stabilize the entire network structure. Therefore, the complex molecules are more likely to decompose or structurally damage when heated, thereby reducing the effect of improving thermal stability.

[0026] When the mass of polyacrylic acid is too high, that is, its content increases, although it can provide more carboxyl groups to react with the chelate, it will also cause the formed cross-linked network to be too tight. In this highly cross-linked network, the relative positions between the chelate and rosavidin molecules may be restricted, so that the synergistic effect between them is disturbed. Specifically, the role of rosavidin in removing damaged keratinocytes and inhibiting melanin synthesis may require a certain degree of spatial freedom to play, and the over-cross-linked network may limit this degree of freedom.

[0027] Preferably, the mass ratio of the chelate to the polyaspartic acid is 4:0.5-0.8.

[0028] By adopting the above technical solution, polyaspartic acid reacts with the hydroxyl groups in the complex molecules to form stable chemical bonds, thereby significantly improving the thermal stability of the complex. If the quality of polyaspartic acid is lower, that is, its content is reduced, the number of carboxyl groups that can participate in the reaction will also be reduced accordingly. This will result in insufficient polyaspartic acid molecules combined with the complex, and it will be impossible to form enough cross-linking points to stabilize the entire network structure. Therefore, the complex molecules are more likely to decompose or structurally damage when heated, thereby reducing the effect of improving thermal stability.

[0029] When the mass of polyaspartic acid is too high, that is, its content increases, although it can provide more carboxyl groups to react with chelators, it will also cause the formed cross-linked network to be too tight. In this highly cross-linked network, the relative positions between chelators and rosavidin molecules may be restricted, so that the synergistic effect between them is disturbed. Specifically, the role of rosavidin in removing damaged keratinocytes and inhibiting melanin synthesis may require a certain degree of spatial freedom to play, and the over-cross-linked network may limit this degree of freedom.

[0030] In a second aspect, the present application provides a method for preparing a cosmetic containing a Rhodiola rosea extract, using the following technical solution: A method for preparing a cosmetic containing a Rhodiola rosea extract, for preparing the cosmetic containing the Rhodiola rosea extract, comprising the following steps: Step 1: Add xanthan gum and carbomer into deionized water according to the formula amount, stir evenly, and obtain a first mixture; Step 2: Add grape seed oil and camellia oil to the first mixture according to the formula amount, and stir evenly to obtain a second mixture; Step 3: Add ascorbic acid, glycerin and sodium hyaluronate to the second mixture according to the formula amount, and stir evenly to obtain a third mixture; Step 4: Add rosarcoma longifolia, rosarcoma longifolia and the carboxyl-containing polymer to the third mixture according to the formula amount, stir evenly, and let stand to obtain cosmetics containing Rhodiola rosea extract.

[0031] By adopting the above technical solution, by gradually adding components with different functions into the base liquid and stirring them fully at each step, it is ensured that each component can be evenly dispersed in the system, avoiding precipitation or stratification of the components, and improving the stability of the product. The preparation method is relatively simple, easy to operate and control, and suitable for large-scale production. Each step is a simple physical mixing process, without the need for complex chemical reactions or high temperature and high pressure conditions, reducing production costs and energy consumption.

[0032] Preferably, the stirring temperature in step 3 is 30-50°C.

[0033] By adopting the above technical solution, water-soluble ingredients such as glycerin and sodium hyaluronate can be well dissolved in deionized water within this temperature range to form a uniform solution. At the same time, ascorbic acid (vitamin C) is relatively stable at this temperature and is not prone to oxidative decomposition, thereby ensuring its whitening and antioxidant effects.

[0034] Although the initial emulsification of the oily components and the basic gel system has been completed in step 2, the stability of the emulsified system needs to be ensured after adding more functional components in step 3. Appropriate heating can promote the movement of surfactant molecules during the emulsification process, enhance the emulsification effect, and better combine the oil phase and the water phase to form a delicate and stable emulsion.

[0035] Preferably, the stirring temperature in step 4 is 20-40°C.

[0036] By adopting the above technical solution, key ingredients such as chorion, rosavidin and carboxyl-containing polymers can remain relatively stable within this temperature range, avoiding degradation or loss of activity caused by high temperature. Appropriate temperature can promote the uniform dispersion and fusion of the ingredients in the mixture, thereby ensuring a fine and uniform texture of the product. At a temperature of 20-40°C, the viscosity of the mixture is moderate, easy to stir and mix, and helps to reduce the formation of bubbles and lumps.

[0037] In summary, this application has the following beneficial effects: 1. Due to the synergistic effect of chorion and rosavirin, the present invention not only effectively removes keratinocytes but also gently inhibits the synthesis of melanin. This formula design not only ensures the skin care effect but also reduces the risk of possible skin damage; 2. The cosmetics containing Rhodiola rosea extract in the present invention also include a carboxyl-containing polymer, which can react with the hydroxyl groups on chorion and rosavirin, connect multiple chorion or rosavirin molecules with polymer molecules, form a network structure, and improve the thermal stability of the product. DETAILED DESCRIPTION

[0038] The raw materials in this application include the following parts: Lanolin: Use a commercial product with CAS number 85026-55-7; Rosavi: a commercially available product with CAS number 84954-92-7 was used; Ascorbic acid: a commercially available product with CAS number 50-81-7 was used; Glycerol: a commercial product with CAS number 56-81-5 was used; Sodium hyaluronate: a commercially available product with CAS number 9067-32-7; Grape seed oil: a commercial product with CAS number 8024-22-4 was used; Camellia oil: a commercial product with CAS number 68916-73-4 was used; Xanthan gum: a commercial product with CAS number 11138-66-2 was used; Carbomer: a commercially available product with CAS number 76050-42-5 was used; Deionized water: Use commercially available product with CAS number 7732-18-5; Polymaleic acid: a commercially available product with CAS number 26099-09-2; Polyacrylic acid: a commercially available product with CAS number 9007-20-9; Polyaspartic acid: a commercially available product with CAS number 25608-40-6 is used; The present application is further described in detail below with reference to examples and comparative examples.

[0039] Example 1 A method for preparing cosmetics containing Rhodiola rosea extract comprises the following steps: Step 1: Add 15 g of xanthan gum and 15 g of carbomer into 900 g of deionized water, stir evenly, at a stirring temperature of 75° C., a stirring rate of 500 rpm, and a stirring time of 0.5 h to obtain a first mixture; Step 2: Add 50 g of grape seed oil and 30 g of camellia oil to the first mixture, stir evenly, stir at a temperature of 60° C., a stirring rate of 200 rpm, and a stirring time of 0.5 h to obtain a second mixture; Step 3: Add 10 g of ascorbic acid, 60 g of glycerol and 20 g of sodium hyaluronate to the second mixture, stir evenly at a stirring temperature of 40° C., a stirring speed of 180 rpm and a stirring time of 0.4 h to obtain a third mixture; Step 4: Add 4 g of rosin and 6 g of rosavitar into the third mixture, stir evenly, stir at a temperature of 30° C., a stirring rate of 100 rpm, and a stirring time of 0.5 h, and let stand to obtain cosmetics containing Rhodiola rosea extract.

[0040] Example 2-3 Example 2-3 Based on the preparation method of Example 1, the content of each component of the cosmetic containing Rhodiola rosea extract was adjusted, and the specific adjustment is shown in Table 1.

[0041] Comparative Examples 1-3 Comparative Examples 1-3 Based on the preparation method of Example 1, the contents of various components of the cosmetics containing Rhodiola rosea extract were adjusted, and the specific adjustments are shown in Table 1.

[0042] Table 1 Content and performance test table of each component of cosmetics containing Rhodiola rosea extract in Examples 1-3 and Comparative Examples 1-3 Performance testing The cosmetics of Examples 1-3 and Comparative Examples 1-3 were subjected to the following performance tests, and the test results are shown in Table 1: 1. Exfoliating properties Cells that have reached the logarithmic growth phase were inoculated into a 96-well plate and a cell suspension was prepared with complete cell culture medium to a cell density of 2.0*10 4 / mL, add 125μL. After the cells are cultured for 24h, add 125μL of cosmetics to the wells. For the negative control, replace 125μL of cosmetics with 125μL of complete cell culture medium.

[0043] Add 200 μL pre-warmed PBS to gently rinse the cells, discard the PBS, add 250 μL of medium containing neutral red to the wells, and incubate for 3 hours. After the incubation, remove the neutral red medium and gently rinse the cells with 250 μL pre-warmed PBS. Pour and drain the PBS, and add 100 μL of neutral red desorption solution to all wells.

[0044] The cell plate was protected from light with tin foil and rapidly shaken on a microtiter plate shaker to extract neutral red from the cells at 10 min, 20 min, and 30 min to form a uniform solution. The cell plate was removed from the shaker and allowed to stand for 5 min. The absorbance was measured at 540 nm.

[0045] Keratinocyte survival rate = (A / A0) * 100%, A is the absorbance of the test sample, A0 is the absorbance of the negative control. The keratinocyte survival rate is preferably 50%-80%, and more preferably 60%-70%. If the survival rate is too low, inflammation is likely to occur when the human body uses it, and if the survival rate is too high, it is difficult to achieve the purpose of removing keratinocytes.

[0046] 2. Inhibit melanin synthesis performance Prepare cell suspension with complete cell culture medium to a cell density of 2.5 × 10 3 / mL, and then the cells were plated in a 6-well plate, 2mL per well. After the plated 6-well plate was placed in a 37℃, 5% CO2 incubator for 24 hours, the cell culture medium was replaced with cosmetics, 2mL per well, and cultured for 72 hours, during which the medium was replaced once, 3ml per well. Note: The negative control group only contains cell culture medium.

[0047] After 72 hours (cell fusion rate reaches more than 90%), measure the cell melanin content. Wash the cells twice with 1×PBS, remove the PBS, add 200μL 0.25% trypsin to each well to digest the cells, and digest them in a CO2 incubator for 5 minutes. Add 2mL PBS twice to blow the cells, collect the cells into a centrifuge tube, and centrifuge at 4000rpm for 5 minutes. Try to suck out the residual PBS in the centrifuge tube, add 200μL of melanin extract to each tube, shake evenly, and heat in an 80℃ water bath for 1 hour. After cooling, centrifuge the droplets on the tube wall moderately, blow evenly, aspirate 150μL of solution in each centrifuge tube, transfer to a 96-well plate, and use an enzyme reader to detect the absorbance of each well at 405nm.

[0048] Calculate the melanin synthesis inhibition rate = [(CT) / (C-C0)]*100%, where T is the absorbance of the test sample, C is the absorbance of the negative control group, and C0 is the background absorbance of the melanin extract.

[0049] Referring to Table 1, it can be seen from the comparison between Examples 1-3 and Comparative Examples 1-3 that, compared with Comparative Examples 1-2, the keratinocyte survival rate of Example 1-3 after 30 minutes is lower than that of Comparative Examples 1-2, and the melanin synthesis inhibition rate is higher than that of Comparative Examples 1-2, indicating that rosa-sinensis and rosa-sinensis can cooperate with each other to have a significant keratinocyte removal effect and promote skin metabolism. At the same time, rosa-sinensis and rosa-sinensis can also cooperate to inhibit the synthesis of melanin, reduce the production of melanin from the source, and have a positive effect on improving uneven skin color and preventing the formation of spots.

[0050] Compared with Comparative Example 3, the survival rate of keratinocytes in Examples 1-3 decreased more slowly, indicating that the cooperation between rosarcoma and rosarcoma can remove keratinocytes more gently and reduce the risk of inflammation as much as possible.

[0051] In addition, by comparing Examples 1-3, it is found that Example 1 has the best performance, so Example 1 is preferred.

[0052] Embodiment 4-7 In Example 4-7, based on the preparation method of Example 1, the amount of rosavidin added was adjusted, and the specific adjustment is shown in Table 2.

[0053] The cosmetics containing Rhodiola rosea extract of Examples 4-7 were subjected to the above performance tests, and the test results are shown in Table 2.

[0054] Table 2 The amount of Rosavi added and the performance test table of Example 1 and Examples 4-7 project Example 1 Example 4 Example 5 Example 6 Example 7 Rosavin / g 6 4 5 7 8 Survival rate after 10 minutes / % 85.5 87.7 86.4 84.2 82.9 Survival rate after 20 minutes / % 74.6 78.5 76.1 72.4 70.1 Survival rate after 30 minutes / % 63.8 69.3 65.9 60.6 57.3 Melanin synthesis inhibition rate / % 85.7 77.5 81.6 86.9 87.1 Referring to Table 2, it can be seen from the comparison between Example 1 and Example 4-7 that when the amount of rosavidin added increases, the survival rate of keratinocytes continues to decrease, and the inhibition rate of melanin synthesis continues to increase. It further illustrates that rosavidin and chorion are synergistic. After chorion removes keratinocytes, rosavidin can further remove damaged keratinocytes and inhibit melanin. Of course, the amount of rosavidin added needs to be kept within a certain range, otherwise if the content is too high, it may still cause unnecessary irritation to the skin. This may cause adverse reactions such as redness, swelling, and sensitivity of the skin, thereby affecting the user experience.

[0055] Examples 8-12 Example 8 Based on the preparation method of Example 1, in step 4, 4 g of chloranthene, 6 g of rosavitin and 0.3 g of polymaleic acid are added to the third mixture at the same time, stirred evenly, and allowed to stand to obtain a cosmetic containing Rhodiola rosea extract, while other conditions remain unchanged.

[0056] In Examples 9-12, based on the preparation method of Example 8, the amount of polymaleic acid added was adjusted. The specific adjustments are shown in Table 3.

[0057] The cosmetics containing Rhodiola rosea extract of Examples 8-12 were subjected to performance testing, and the test results are shown in Table 3.

[0058] Table 3 Addition amount and performance test table of polymaleic acid in Example 1 and Examples 8-12 Performance Test The cosmetics were placed at 50°C for 7 days, and then the above-mentioned exfoliation performance test (keratinocyte survival rate after 30 minutes) and melanin synthesis inhibition performance test were carried out.

[0059] As shown in Table 3, by comparing Example 1 with Examples 8-12, it can be seen that adding polymaleic acid to cosmetics can effectively improve the thermal stability of cosmetics. This may be because polymaleic acid reacts with the hydroxyl groups in the complex molecules to form stable chemical bonds, which significantly improves the thermal stability of the complex, thereby improving the thermal stability of the cosmetics.

[0060] When the quality of polymaleic acid is too high, that is, its content increases, although it can provide more carboxyl groups to react with the chelate, it will also cause the formed cross-linked network to be too tight. In this highly cross-linked network, the relative position between the chelate and rosavidin molecules may be restricted, so that the synergistic effect between them is disturbed, thereby reducing the cosmetic's ability to clear keratinocytes and inhibit melanin synthesis.

[0061] Examples 13-17 Example 13 Based on the preparation method of Example 1, in step 4, 4 g of chloranthene, 6 g of rosavitin and 0.5 g of polyacrylic acid are added to the third mixture at the same time, stirred evenly, and allowed to stand to obtain a cosmetic containing Rhodiola rosea extract, while other conditions remain unchanged.

[0062] In Examples 14-17, based on the preparation method of Example 13, the amount of polyacrylic acid added was adjusted. The specific adjustments are shown in Table 4.

[0063] The cosmetics containing Rhodiola rosea extract of Examples 13-17 were subjected to the above performance tests, and the test results are shown in Table 4.

[0064] Table 4 Addition amount and performance test table of polyacrylic acid in Example 1 and Examples 13-17 Referring to Table 4, by comparing Example 1 with Examples 13-17, it can be seen that adding polyacrylic acid to cosmetics can effectively improve the thermal stability of cosmetics. This may be because polyacrylic acid reacts with the hydroxyl groups in the complex molecules to form stable chemical bonds, which significantly improves the thermal stability of the complex, thereby improving the thermal stability of the cosmetics.

[0065] When the mass of polyacrylic acid is too high, that is, its content increases, although it can provide more carboxyl groups to react with the chelate, it will also cause the formed cross-linked network to be too tight. In this highly cross-linked network, the relative positions between the chelate and rosavidin molecules may be restricted, so that the synergistic effect between them is disturbed, thereby reducing the cosmetic's ability to clear keratinocytes and inhibit melanin synthesis.

[0066] Examples 18-22 Example 18 Based on the preparation method of Example 1, in step 4, 4 g of chloranthene, 6 g of rosavitin and 0.7 g of polyaspartic acid are added to the third mixture at the same time, stirred evenly, and allowed to stand to obtain a cosmetic containing Rhodiola rosea extract, while other conditions remain unchanged.

[0067] In Examples 19-22, based on the preparation method of Example 18, the amount of polyaspartic acid added was adjusted. The specific adjustments are shown in Table 5.

[0068] The cosmetics containing Rhodiola rosea extract of Examples 18-22 were subjected to the above performance tests, and the test results are shown in Table 5.

[0069] Table 5 Addition amount and performance test table of polyaspartic acid in Example 1 and Examples 18-22 Referring to Table 5, by comparing Example 1 with Examples 18-22, it can be seen that adding polyaspartic acid to cosmetics can effectively improve the thermal stability of cosmetics. This may be because polyaspartic acid reacts with the hydroxyl groups in the complex molecules to form stable chemical bonds, which significantly improves the thermal stability of the complex, thereby improving the thermal stability of the cosmetics.

[0070] When the mass of polyaspartic acid is too high, that is, its content increases, although it can provide more carboxyl groups to react with the chelate, it will also cause the formed cross-linked network to be too tight. In this highly cross-linked network, the relative positions between the chelate and rosavidin molecules may be restricted, so that the synergistic effect between them is disturbed, thereby reducing the cosmetic's ability to clear keratinocytes and inhibit melanin synthesis.

[0071] Examples 23-26 In Examples 23-26, based on the preparation method of Example 1, the stirring temperature of step 3 was adjusted, and the specific adjustments are shown in Table 6.

[0072] The cosmetics containing Rhodiola rosea extract of Examples 23-26 were subjected to the above performance tests, and the test results are shown in Table 6 respectively.

[0073] Table 6 Stirring temperature and performance test table of step 3 of Example 1 and Examples 23-26 project Example 1 Embodiment 23 Embodiment 24 Embodiment 25 Embodiment 26 Stirring temperature / ℃ 40 25 30 50 55 Survival rate after 30 minutes / % 63.8 72.4 68.2 66.1 71.5 Melanin synthesis inhibition rate / % 85.7 78.6 80.7 83.2 79.4 Referring to Table 6, by comparing Example 1 with Examples 23-26, it can be seen that as the stirring temperature of step 3 continues to increase, the keratinocyte survival rate shows a trend of first decreasing and then increasing, and the melanin synthesis inhibition rate shows a trend of first increasing and then decreasing. This may be because as the stirring temperature of step 3 continues to increase, water-soluble ingredients such as glycerin and sodium hyaluronate can be better dissolved in deionized water to form a uniform solution, thereby increasing the keratinocyte removal performance and melanin synthesis inhibition performance of the cosmetics containing Rhodiola rosea extract; when the stirring temperature of step 3 exceeds a certain range, the molecular structure of some ingredients may be destroyed, so that the stability of the cosmetics containing Rhodiola rosea extract is reduced, thereby reducing the melanin synthesis inhibition performance of the cosmetics containing Rhodiola rosea extract.

[0074] Examples 27-30 In Examples 27-30, based on the preparation method of Example 1, the stirring temperature of step 4 was adjusted, and the specific adjustments are shown in Table 7.

[0075] The cosmetics containing Rhodiola rosea extract of Examples 27-30 were subjected to the above performance tests, and the test results are shown in Table 7 respectively.

[0076] Table 7 Stirring temperature and performance test table of step 4 of Example 1 and Examples 27-30 and Comparative Examples 12-13 Referring to Table 7, by comparing Example 1 and Examples 27-30, it can be seen that as the stirring temperature of step 4 continues to increase, the keratinocyte survival rate shows a trend of first decreasing and then increasing, and the melanin synthesis inhibition rate shows a trend of first increasing and then decreasing. This may be because as the stirring temperature of step 4 continues to increase, chorion and rosavirin can be better dissolved in the third mixture to form a uniform solution, thereby increasing the keratinocyte removal performance and melanin synthesis inhibition performance of the cosmetics containing Rhodiola rosea extract; when the stirring temperature of step 4 exceeds a certain range, the molecular structure of some components may be destroyed, so that the stability of the cosmetics containing Rhodiola rosea extract is reduced, thereby reducing the melanin synthesis inhibition performance of the cosmetics containing Rhodiola rosea extract.

[0077] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A cosmetic containing a Rhodiola rosea extract, characterized in that: The invention comprises the following components in parts by weight: 0.3-0.5 parts of chorion, 0.4-0.8 parts of rosavitin, 0.1-1.5 parts of ascorbic acid, 4-8 parts of glycerol, 0.5-3 parts of sodium hyaluronate, 3-6 parts of grape seed oil, 2-4 parts of camellia oil, 1-2 parts of xanthan gum, 1-2 parts of carbomer and 90 parts of deionized water.

2. The cosmetic containing Rhodiola rosea extract according to claim 1, characterized in that: The mass ratio of the plexiglass to the plexiglass is 0.4:0.5-0.

7.

3. The cosmetic containing Rhodiola rosea extract according to claim 1, characterized in that: Also included are polymers containing carboxyl groups.

4. The cosmetic containing Rhodiola rosea extract according to claim 3, characterized in that: The carboxyl-containing polymer includes at least one of polymaleic acid, polyacrylic acid, and polyaspartic acid.

5. The cosmetic containing Rhodiola rosea extract according to claim 4, characterized in that: The mass ratio of the chelate to the polymaleic acid is 4:0.2-0.

4.

6. The cosmetic containing Rhodiola rosea extract according to claim 4, characterized in that: The mass ratio of the chelate to the polyacrylic acid is 4:0.4-0.

6.

7. The cosmetic containing Rhodiola rosea extract according to claim 4, characterized in that: The mass ratio of the chelate to the polyaspartic acid is 4:0.5-0.

8.

8. The method for preparing a cosmetic containing a Rhodiola rosea extract according to any one of claims 1 to 7, characterized in that: Step 1: Add xanthan gum and carbomer into deionized water according to the formula amount, stir evenly, and obtain a first mixture; Step 2: Add grape seed oil and camellia oil to the first mixture according to the formula amount, and stir evenly to obtain a second mixture; Step 3: Add ascorbic acid, glycerin and sodium hyaluronate to the second mixture according to the formula amount, and stir evenly to obtain a third mixture; Step 4: Add rosarcoma longifolia, rosarcoma longifolia and the carboxyl-containing polymer to the third mixture according to the formula amount, stir evenly, and let stand to obtain cosmetics containing Rhodiola rosea extract.

9. The method for preparing cosmetics containing Rhodiola rosea extract according to claim 8, characterized in that: The stirring temperature in step 3 is 30-50°C.

10. The method for preparing cosmetics containing Rhodiola rosea extract according to claim 8, characterized in that: The stirring temperature in step 4 is 20-40°C.

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