Traditional Chinese medicine composition used after laparoscopic surgery for assisting pregnancy of salpingemphraxis infertility

Abstract

The invention relates to a traditional Chinese medicine composition used after a laparoscopic surgery for assisting pregnancy of fallopian tube obstructive infertility. Cassia twig, salvia miltiorrhiza, rhizoma atractylodis, semen coicis, poria cocos, radix paeoniae rubra and the like; the traditional Chinese medicine composition reflects the combination of the traditional Chinese medicine theory and the modern medical technology, and aims to solve the complex problem of fallopian tube obstructive infertility; through a traditional Chinese medicine retention enema mode, the therapy attempts to improve the pelvic cavity microenvironment, promote local blood circulation, reduce inflammation and adhesion and improve the functional patency of the fallopian tube, so that good conditions are provided for meeting of ova and sperms; the ingredients of the traditional Chinese medicine composition disclosed by the invention consider various traditional Chinese medicinal materials with different effects, such as reducing phlegm, removing dampness, promoting blood circulation to remove meridian obstruction and the like, so as to cope with the pathological mechanism of phlegm and blood stasis intermingling; clinical results show that the traditional Chinese medicine composition has positive influence on improvement of salpingemphraxis infertility when being used for treatment.

Description

Technical Field

[0001] The invention belongs to the technical field of traditional Chinese medicine compositions, and particularly relates to a traditional Chinese medicine composition for assisting pregnancy after laparoscopic surgery for infertility caused by fallopian tube obstruction. Background Art

[0002] Infertility is a difficult disease that has attracted worldwide attention. Among them, infertility due to fallopian tube obstruction accounts for 67% of the total incidence, ranking first among tubal infertility. With the development and maturity of laparoscopic minimally invasive technology, it has been widely used in the diagnosis and treatment of tubal obstruction infertility. Laparoscopy can directly visualize fallopian tube lesions and the internal conditions of the pelvic cavity, restore the normal anatomical structure of the fallopian tube and the patency of the lumen, but it is not equivalent to restoring its physiological function, and cannot prevent re-blockage after surgery. After laparoscopic surgery for tubal obstruction infertility, there are problems such as re-blockage, infection, pain, low pregnancy rate, and ectopic pregnancy in the fallopian tube. Summary of the invention

[0003] The present invention aims to provide a Chinese medicine composition for assisting pregnancy after laparoscopic surgery for infertility caused by fallopian tube obstruction, so as to solve the technical problems existing in the existing laparoscopic surgery for infertility caused by fallopian tube obstruction.

[0004] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0005] A traditional Chinese medicine composition for assisting pregnancy after laparoscopic surgery for infertility caused by fallopian tube obstruction is prepared from the following raw materials by weight: 20-30g of cassia twig, 20-30g of salvia miltiorrhiza, 20-30g of atractylodes, 30-40g of coix seed, 20-30g of tuckahoe, 20-30g of red peony root, 15-20g of peach kernel, 20-30g of angelica, 20-30g of chuanxiong, 15-20g of dried ginger, 20-30g of corydalis, 20-30g of fennel, and 15-20g of cyperus.

[0006] Preferably, the Chinese medicine composition for assisting pregnancy after laparoscopic surgery for infertility caused by fallopian tube obstruction is made from the following raw materials by weight: 25g of cinnamon twig, 20g of salvia miltiorrhiza, 26g of atractylodes, 32g of coix seed, 23g of poria, 28g of red peony root, 16g of peach kernel, 25g of angelica, 25g of chuanxiong, 18g of dried ginger, 22g of Corydalis yanhusuo, 25g of Smilax glabra, and 17g of Cyperus rotundus.

[0007] Preferably, the Chinese medicine composition for assisting pregnancy after laparoscopic surgery for infertility caused by fallopian tube obstruction is made from the following raw materials by weight: 22g of cinnamon twig, 25g of salvia miltiorrhiza, 28g of atractylodes, 36g of coix seed, 25g of poria, 23g of red peony root, 16g of peach kernel, 28g of angelica, 28g of chuanxiong, 18g of dried ginger, 25g of Corydalis yanhusuo, 27g of Scolopendra subspinipes, and 18g of Cyperus rotundus.

[0008] Compared with the prior art, the beneficial effects of the present invention are: the Chinese medicine composition of the present invention embodies the combination of traditional Chinese medicine theory and modern medical technology, and aims to solve the complex problem of tubal obstructive infertility; through the method of Chinese medicine retention enema, this therapy attempts to improve the pelvic microenvironment, promote local blood circulation, reduce inflammation and adhesion, and improve the functional patency of the fallopian tube, thereby providing good conditions for the encounter between the egg and the sperm; the ingredients of the Chinese medicine composition of the present invention consider a variety of Chinese medicinal materials with different effects, such as phlegm and dampness, blood circulation and collaterals, etc., to cope with the pathological mechanism of "phlegm and blood stasis". In addition, the first-pass effect of the gastrointestinal tract can be bypassed by rectal administration, so that the drug can act more directly on the lesion site, which can theoretically improve the therapeutic effect and reduce side effects; clinical observation results show that in patients treated with the Chinese medicine composition, the cure rate and total effective rate are significantly higher than those of the control group using only conventional treatment methods, which indicates that the treatment method may have a positive effect on improving tubal obstructive infertility. DETAILED DESCRIPTION

[0009] The technical solutions in the embodiments of the present invention are described clearly and completely below. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0010] The present invention is further described in detail below in conjunction with embodiments.

[0011] A traditional Chinese medicine composition for assisting pregnancy after laparoscopic surgery for infertility caused by fallopian tube obstruction is prepared from the following raw materials by weight: 20-30g of cassia twig, 20-30g of salvia miltiorrhiza, 20-30g of atractylodes, 30-40g of coix seed, 20-30g of tuckahoe, 20-30g of red peony root, 15-20g of peach kernel, 20-30g of angelica, 20-30g of chuanxiong, 15-20g of dried ginger, 20-30g of corydalis, 20-30g of fennel, and 15-20g of cyperus.

[0012] The basic theory of traditional Chinese medicine used in the above-mentioned Chinese medicine composition is: based on the theory of homology of phlegm and blood stasis, the body fluid is transported and transformed into phlegm due to dysfunction, stagnation and accumulation, and blood stasis and phlegm stagnate in the meridians, causing phlegm and blood stasis to stagnate in the meridians, and then flow down to the cell network, resulting in blocked meridians, edema and effusion of the fallopian tubes, and blockage of the fallopian tubes over time, and loss of function leading to infertility. Therefore, the treatment is based on the theory of "phlegm and blood stasis", with "unblocking" as the main line, and the principles of phlegm removal, dehumidification, blood circulation and collateral dredging. The efficacy of Chinese medicine retention enema maintains a certain temperature and drug concentration at the lesion site, improves the bioavailability effect, avoids the first-pass effect of the drug digestive system and the deficiency of young women's unwillingness to take Chinese medicine orally. Traditional Chinese medicine retention enema uses drugs that soften and resolve phlegm, promote blood circulation and remove blood stasis to dredge the meridians, improve the pelvic microenvironment, improve the blood circulation rheology of the fallopian tubes, strengthen the ciliary function of the fallopian tube cavity, promote the absorption of inflammatory mediators, eliminate fallopian tube obstruction, loosen surrounding adhesions, and promote the peristalsis of the fallopian tubes to provide a pathway for the egg and the fertilized egg to promote pregnancy.

[0013] Among the above drugs:

[0014] Cinnamon twig: warms and dredges the meridians, and dissolves phlegm and fluid. "Compendium of Materia Medica": warms and dredges the meridians, and induces sweating and relieves muscle pain.

[0015] Danshen: activates blood circulation and removes blood stasis, specializes in treating blood stasis. "Shennong's Herbal Classic": treats evil qi in the heart and abdomen, eliminates tumors and masses. "Bencao Qiuzhen": enters the pericardium and removes blood stasis.

[0016] Atractylodes: Drying dampness, strengthening the spleen, and removing rheumatism. "Shennong's Herbal Classic": Treats wind-cold-damp arthralgia, dead muscle spasm and jaundice.

[0017] Coix seeds: promote diuresis and eliminate dampness, clear away heat and discharge pus, and eliminate numbness. "Compendium of Materia Medica": It can eliminate dampness and relieve diarrhea and edema.

[0018] Poria: promotes diuresis and eliminates dampness. "Shibuzhai Medical Book" says: It is the main medicine for treating phlegm, which can promote diuresis and eliminate dampness.

[0019] Red peony root: clears heat and cools blood, removes blood stasis and relieves pain. "Shennong's Herbal Classic": It treats abdominal pain caused by evil qi, removes blood stasis, breaks up hard masses and relieves pain.

[0020] Peach kernel: promotes blood circulation and removes blood stasis. "Shennong's Herbal Classic": treats blood stasis, blood stasis and masses. "Famous Doctors' Records": dissolves masses, promotes menstruation, and relieves pain.

[0021] Angelica: nourishes blood and activates blood circulation. "Rihuazi Bencao": breaks up bad blood, nourishes new blood and cures symptoms and addictions.

[0022] Chuanxiong: Activates blood circulation and promotes qi. "Compendium of Materia Medica" says: It is good at dispersing, and is a blood medicine in the qi. It can move the head and eyes upward, relieve depression in the middle, and regulate menstruation downward.

[0023] Yanhusuo: activating blood circulation, promoting qi circulation, relieving pain. "Compendium of Materia Medica": It can relieve stagnation and promote blood circulation, treat diseases of internal and external qi and blood stagnation, and relieve stagnation and resolve knots.

[0024] Lulutong: dispels dampness and dredges meridians, promotes diuresis and dredges menstruation. "Supplement to Compendium of Materia Medica": it can open twelve meridian points and can search and expel hidden water.

[0025] Dried ginger: warms and dissolves phlegm and dampness. "Zhenzhu Nang": removes coldness and chronic coldness in the internal organs, releases coldness in the meridians, and removes dampness and arthralgia.

[0026] Cyperus rotundus: It can nourish the qi of the twelve meridians, dispel phlegm and dampness, and benefit the three burners.

[0027] The combination of the above-mentioned medicines can achieve the effects of eliminating phlegm and dampness, promoting blood circulation, removing blood stasis and dredging collaterals, maintaining continuous patency of the fallopian tubes, restoring the function of the fallopian tubes, reducing the reocclusion of the fallopian tubes, avoiding the limitations of single laparoscopic treatment, combining Chinese and Western medicine, each playing to its strengths, and improving the efficacy of pregnancy.

[0028] Embodiment: A traditional Chinese medicine composition for assisting pregnancy after laparoscopic surgery for infertility caused by fallopian tube obstruction, composed of the following raw materials: including the following raw materials by weight: 25g of cinnamon twig, 20g of salvia miltiorrhiza, 26g of atractylodes, 32g of coix seed, 23g of poria, 28g of red peony root, 16g of peach kernel, 25g of angelica, 25g of chuanxiong, 18g of dried ginger, 22g of Corydalis yanhusuo, 25g of Scolopendra subspinipes, and 17g of Cyperus rotundus.

[0029] The above raw materials are concentrated into 300ml, and then used for enema, 150ml each time, once a day, and used for 10 consecutive days per month as a course of treatment; the enema method is: the above medicine is concentrated into 300ml, divided into 2 bags, one bag of 150ml each time, the medicine temperature is 39-40℃, empty the bowels and stools, lie on the side, raise the buttocks 10-20cm, pour the medicine into the infusion bottle, connect the infusion set, expose the anus, lubricate the front end of the anal canal, gently insert the anus about 10-12cm, slowly drip the medicine (60-90 drops / min), after the medicine is finished, slowly pull out the anal canal, and ask the patient to retain the medicine for at least 2 hours.

[0030] The retention enema of the present invention has 50%-70% of the drug absorbed through the rectum, which is absorbed through the intestinal mucosa and directly reaches the fallopian tube lesions, and has the functions of improving local microcirculation, antibacterial, anti-inflammatory, loosening adhesions, repairing and unblocking the fallopian tube. The advantages of traditional Chinese medicine retention enema combined with laparoscopic minimally invasive technology for this disease can achieve complementary advantages and improve the pregnancy rate. The present invention has achieved good results through clinical application, and its relevant information is as follows:

[0031] 1) Basic information

[0032] Since 2022, 100 patients with fallopian tube obstruction infertility who underwent laparoscopic surgery came to our hospital for treatment and were clinically observed and treated. All cases were diagnosed with fallopian tube obstruction infertility through laparoscopy and repaired and unblocked. They were randomly divided into a treatment group and a control group, with 50 people in each group. There was no significant difference in age, condition, etc. between the two groups of patients, and they were comparable.

[0033] 2) Treatment methods

[0034] Control group: After routine postoperative treatment, the development of follicles was monitored by B-ultrasound starting from the 10th day of the next menstrual cycle, once every other day until the follicles developed into mature follicles (18-20mm). Sexual intercourse was guided until the follicles disappeared, and monitoring was continued for 3 months.

[0035] Treatment group: routine treatment after laparoscopic surgery, starting from the second day, the Chinese medicine composition of this embodiment for assisted pregnancy after laparoscopic surgery for infertility caused by fallopian tube obstruction was given, normal sexual life during the treatment period, and the treatment course was terminated if pregnancy occurred, and if pregnancy did not occur, the medication was started after the menstruation was over, and the treatment was continued for 3 courses, and the ovarian follicle monitoring and guidance of pregnancy were the same as those of the control group.

[0036] 3) Efficacy evaluation criteria

[0037] Recovery: pregnancy (intrauterine pregnancy), or after treatment, the fallopian tube is re-examined for hysterosalpingography, and the fallopian tube changes from being unobstructed or blocked to being unobstructed;

[0038] Improvement: No pregnancy, after treatment, the fallopian tube was blocked and then became unobstructed;

[0039] Ineffective: Not pregnant, or ectopic pregnancy, or no obvious changes in the fallopian tube after treatment.

[0040] 4) Treatment effect

[0041] After three courses of treatment, the intrauterine pregnancy was observed within one year. The comparison of the efficacy of the two groups is shown in the following table:

[0042]

[0043] Conclusion: The cure rate was 56% in the treatment group and 32% in the control group. The total effective rate was 86% in the treatment group and 56% in the control group. The data of the two groups were significantly better in the treatment group than in the control group.

[0044] It should be noted that, in this article, terms such as "comprises", "includes" or any other variations thereof are intended to cover non-exclusive inclusion, so that a process, method, article or apparatus that includes a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or apparatus.

[0045] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A Chinese medicine composition for assisting pregnancy after laparoscopic surgery for infertility caused by fallopian tube obstruction, characterized in that: The invention comprises the following raw materials by weight: 20-30g of cassia twig, 20-30g of salvia miltiorrhiza, 20-30g of atractylodes, 30-40g of coix seed, 20-30g of tuckahoe, 20-30g of red peony root, 15-20g of peach kernel, 20-30g of angelica sinensis, 20-30g of chuanxiong, 15-20g of dried ginger, 20-30g of yanhusuo, 20-30g of fennel and 15-20g of cyperus rotundus.

2. The Chinese medicine composition for assisting pregnancy after laparoscopic surgery for infertility caused by fallopian tube obstruction according to claim 1, characterized in that: The invention is prepared from the following raw materials by weight: 25g of cinnamon twig, 20g of salvia miltiorrhiza, 26g of atractylodes, 32g of coix seed, 23g of tuckahoe, 28g of red peony root, 16g of peach kernel, 25g of angelica sinensis, 25g of chuanxiong, 18g of dried ginger, 22g of Corydalis yanhusuo, 25g of rhizoma smilacis Glabrae, and 17g of cyperus rotundus.

3. The Chinese medicine composition for assisting pregnancy after laparoscopic surgery for infertility caused by fallopian tube obstruction according to claim 1, characterized in that: The invention is prepared from the following raw materials by weight: 22g of cinnamon twig, 25g of salvia miltiorrhiza, 28g of atractylodes, 36g of coix seed, 25g of tuckahoe, 23g of red peony root, 16g of peach kernel, 28g of angelica sinensis, 28g of chuanxiong, 18g of dried ginger, 25g of yanhusuo, 27g of fennel and 18g of cyperus rotundus.

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