Antioxidant skin care product containing red ginseng extract and preparation method thereof

Abstract

The invention discloses an antioxidant skin care product containing a red ginseng extract and a preparation method of the antioxidant skin care product, and relates to the technical field of skin care products. The antioxidant skin care product comprises the following raw materials in parts by weight: 15-35 parts of a red ginseng extract, 10-20 parts of a pomegranate peel extract, 10-20 parts of a poplar phellinus igniarius extract, 1-10 parts of an emulsifier, 5-15 parts of a humectant, 0.5-1.5 parts of a thickener, 1-3 parts of squalene, 1-5 parts of vitamin E and 30-50 parts of water. The skin care product disclosed by the invention has excellent antioxidant and antibacterial properties, and can meet storage requirements without additionally adding preservatives.

Description

Technical Field

[0001] The present invention relates to the technical field of skin care products, in particular to an antioxidant skin care product containing a red ginseng extract and a preparation method thereof. Background Art

[0002] Red ginseng (Panax ginseng CA Meyer) is a traditional Chinese medicinal material with a variety of bioactive ingredients, including ginsenosides, polysaccharides, amino acids, proteins and volatile oils. In recent years, the effects of red ginseng extract in anti-oxidation, anti-aging, anti-inflammatory and anti-allergic aspects have received widespread attention. Studies have shown that arginine glycoside (AFG) in red ginseng extract has significant antioxidant activity, can scavenge free radicals and delay cell aging. In addition, red ginseng extract has been shown to inhibit histamine release and has anti-allergic effects, which provides a scientific basis for its application in skin care products.

[0003] At present, red ginseng extract has been widely used in skin care products, such as lotions, emulsions, creams, masks, etc. Its antioxidant and anti-aging effects make it an important ingredient in functional skin care products. For example, skin care products containing red ginseng extract can significantly remove superoxide anion free radicals, reduce skin oxidative damage, and delay skin aging. In addition, red ginseng extract is also used in whitening and anti-freckle products to improve skin pigmentation and make the skin more delicate and smooth by promoting skin metabolism and blood circulation.

[0004] The object of the present invention is to develop a skin care product comprising a red ginseng extract and having excellent antioxidant properties. Summary of the invention

[0005] Based on the technical problems existing in the background technology, the present invention proposes an antioxidant skin care product containing red ginseng extract and a preparation method thereof. The skin care product has excellent antioxidant and antibacterial properties and can meet storage requirements without the addition of additional preservatives.

[0006] The present invention provides an antioxidant skin care product containing red ginseng extract, which contains the following raw materials in parts by weight: 25-35 parts of red ginseng extract, 15-25 parts of pomegranate peel extract, 15-25 parts of poplar mulberry extract, 1-10 parts of emulsifier, 5-15 parts of moisturizer, 0.5-1.5 parts of thickener, 1-3 parts of squalene, 1-5 parts of vitamin E, and 30-50 parts of water.

[0007] Preferably, the preparation method of the red ginseng extract has the following steps: the red ginseng obtained after crushing is subjected to ultrasonic alcohol extraction under the action of a composite enzyme, and the product is subjected to enzyme inactivation, centrifugation, concentration and drying to obtain the red ginseng extract.

[0008] Preferably, the solvent for alcohol extraction is 70% ethanol, and the solid-liquid ratio is 1:10-20; Ultrasonic power 200-400W, alcohol extraction time 30-60min, alcohol extraction temperature 50-70℃; The complex enzyme is composed of cellulase and papain in a mass ratio of 2:1-4, and the added amount of the complex enzyme is 1-3% of the mass of the red ginseng.

[0009] Preferably, the preparation method of the pomegranate peel extract comprises the following steps: the pomegranate peel is dried and crushed, then ultrasonically extracted with water under the action of a complex enzyme, and the product is inactivated, centrifuged, concentrated and dried to obtain the pomegranate peel extract.

[0010] Preferably, the material-liquid ratio is 1:10-30; Ultrasonic power 350-450W, water extraction time 20-40min, water extraction temperature 70-90℃; The compound enzyme is composed of pectinase, papain and neutral protease in a mass ratio of 3:1-9:1-9, and the added amount of the compound enzyme is 1-5% of the mass of the pomegranate peel.

[0011] Preferably, the poplar mulberry linterus extract is a poplar mulberry linterus water extract or a poplar mulberry linterus alcohol extract.

[0012] Preferably, the emulsifier is one or more of sucrose stearate, glyceryl stearate, lecithin, sorbitan ester, polyglycerol ester and whey protein.

[0013] Preferably, the moisturizing agent is one or more of glycerin, hyaluronic acid, aloe extract, trehalose, olive oil and erythritol.

[0014] Preferably, the thickener is one or more of xanthan gum, carrageenan, sodium alginate and caprylic / capric triglyceride.

[0015] The present invention provides a method for preparing an antioxidant skin care product containing red ginseng extract. The antioxidant skin care product is as described above, and the method steps are as follows: the components of the antioxidant skin care product are evenly mixed, and after homogenization and emulsification, the antioxidant skin care product containing red ginseng extract is obtained.

[0016] Mechanism of action: Skin aging is closely related to oxidative stress. Excessive production of free radicals will attack skin cells, leading to collagen degradation, lipid peroxidation and DNA damage, and ultimately causing skin sagging, wrinkles, spots and other problems. The three natural extracts in the present invention are rich in antioxidant ingredients, which can work synergistically to effectively remove free radicals and protect skin cells from oxidative damage.

[0017] Ginsenosides, polysaccharides and phenolic compounds in red ginseng have strong antioxidant activity. Studies have shown that red ginseng extract can significantly increase the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in the skin, enhance the skin's antioxidant defense system, effectively scavenge free radicals, and delay skin aging. Pomegranate peel is rich in polyphenols such as ellagic acid and punicalagin, and has excellent antioxidant capacity. Studies have shown that pomegranate peel extract can effectively inhibit lipid peroxidation, reduce the production of reactive oxygen species (ROS), protect skin cell membranes from oxidative damage, and maintain skin elasticity and luster. Poplar mulberry is a rare medicinal fungus rich in polysaccharides, flavonoids and triterpenoids. Studies have shown that poplar mulberry extract has significant antioxidant activity, can scavenge a variety of free radicals, inhibit lipid peroxidation, protect skin cells from oxidative stress damage, and delay skin aging.

[0018] The red ginseng extract, pomegranate peel extract and poplar mulberry linterus extract of the present invention significantly improve the antioxidant properties of skin care products through multi-pathway and multi-target synergistic promotion, can more effectively scavenge free radicals, inhibit lipid peroxidation, enhance the activity of antioxidant enzymes, and maintain the redox balance in cells, thereby exerting a stronger antioxidant effect.

[0019] Beneficial technical effects of the present invention: The present invention uses red ginseng extract, pomegranate peel extract and poplar mulberry linterus extract as main raw materials, and squalene and vitamin E as functional additives. The prepared skin care product not only has excellent antioxidant performance, but also has excellent antibacterial performance, and can meet storage requirements without the need to add additional preservatives. DETAILED DESCRIPTION

[0020] The present invention will be further explained below in conjunction with specific embodiments.

[0021] Example 1

[0022] The antioxidant skin care product containing red ginseng extract proposed by the present invention comprises the following raw materials in parts by weight: 40 parts of red ginseng extract, 30 parts of pomegranate peel extract, 20 parts of poplar mulberry extract, 5 parts of emulsifier, 10 parts of moisturizer, 1 part of thickener, 2 parts of squalene, 3 parts of vitamin E, and 40 parts of water.

[0023] The components of the antioxidant skin care product are uniformly mixed and emulsified to obtain the antioxidant skin care product containing the red ginseng extract.

[0024] The steps of the preparation method of the red ginseng extract are as follows: the red ginseng is crushed and then ultrasonically extracted with alcohol under the action of a composite enzyme, and the product is inactivated, centrifuged, concentrated and dried to obtain the red ginseng extract.

[0025] The solvent for alcohol extraction is 70% ethanol, and the solid-liquid ratio is 1:15; the ultrasonic power is 300W, the alcohol extraction time is 45min, and the alcohol extraction temperature is 60℃; the complex enzyme is composed of cellulase and papain in a mass ratio of 1:1, and the addition amount of the complex enzyme is 2% of the mass of red ginseng.

[0026] The preparation method of the pomegranate peel extract comprises the following steps: the pomegranate peel is dried and crushed, then ultrasonically extracted with water under the action of a composite enzyme, and the product is inactivated, centrifuged, concentrated and dried to obtain the pomegranate peel extract.

[0027] The solid-liquid ratio is 1:20; the ultrasonic power is 400 W, the water extraction time is 30 min, and the water extraction temperature is 80°C; the complex enzyme is composed of pectinase, papain and neutral protease in a mass ratio of 1:1:1, and the addition amount of the complex enzyme is 3% of the mass of pomegranate peel.

[0028] The poplar mulberry linterus extract is a water extract of poplar mulberry linterus; the emulsifier is glyceryl stearate; the moisturizer is composed of hyaluronic acid and aloe extract in a mass ratio of 1:1; and the thickener is caprylic / capric triglyceride.

[0029] Example 2

[0030] The antioxidant skin care product containing red ginseng extract proposed by the present invention comprises the following raw materials in parts by weight: 25 parts of red ginseng extract, 15 parts of pomegranate peel extract, 15 parts of poplar mulberry extract, 1 part of emulsifier, 5 parts of moisturizer, 0.5 part of thickener, 1 part of squalene, 1 part of vitamin E, and 30 parts of water.

[0031] The components of the antioxidant skin care product are uniformly mixed and emulsified to obtain the antioxidant skin care product containing the red ginseng extract.

[0032] The steps of the preparation method of the red ginseng extract are as follows: the red ginseng is crushed and then ultrasonically extracted with alcohol under the action of a composite enzyme, and the product is inactivated, centrifuged, concentrated and dried to obtain the red ginseng extract.

[0033] The solvent for alcohol extraction is 70% ethanol, and the solid-liquid ratio is 1:10; the ultrasonic power is 200W, the alcohol extraction time is 60min, and the alcohol extraction temperature is 50°C; the complex enzyme is composed of cellulase and papain in a mass ratio of 2:1, and the addition amount of the complex enzyme is 1% of the mass of red ginseng.

[0034] The preparation method of the pomegranate peel extract comprises the following steps: the pomegranate peel is dried and crushed, then ultrasonically extracted with water under the action of a composite enzyme, and the product is inactivated, centrifuged, concentrated and dried to obtain the pomegranate peel extract.

[0035] The solid-liquid ratio is 1:10; the ultrasonic power is 350W, the water extraction time is 40min, and the water extraction temperature is 70℃; the complex enzyme is composed of pectinase, papain and neutral protease in a mass ratio of 3:1:1, and the addition amount of the complex enzyme is 1% of the mass of pomegranate peel.

[0036] The poplar mulberry linterus extract is the poplar mulberry linterus alcohol extract; the emulsifier is sorbitan ester; the moisturizer is glycerin; and the thickener is sodium alginate.

[0037] Example 3

[0038] The antioxidant skin care product containing red ginseng extract proposed by the present invention comprises the following raw materials in parts by weight: 35 parts of red ginseng extract, 25 parts of pomegranate peel extract, 25 parts of poplar mulberry extract, 10 parts of emulsifier, 15 parts of moisturizer, 1.5 parts of thickener, 3 parts of squalene, 5 parts of vitamin E, and 50 parts of water.

[0039] The components of the antioxidant skin care product are uniformly mixed and emulsified to obtain the antioxidant skin care product containing the red ginseng extract.

[0040] The steps of the preparation method of the red ginseng extract are as follows: the red ginseng is crushed and then ultrasonically extracted with alcohol under the action of a composite enzyme, and the product is inactivated, centrifuged, concentrated and dried to obtain the red ginseng extract.

[0041] The solvent for alcohol extraction is 70% ethanol, and the solid-liquid ratio is 1:20; the ultrasonic power is 400W, the alcohol extraction time is 30min, and the alcohol extraction temperature is 70℃; the complex enzyme is composed of cellulase and papain in a mass ratio of 1:2, and the addition amount of the complex enzyme is 3% of the mass of red ginseng.

[0042] The preparation method of the pomegranate peel extract comprises the following steps: the pomegranate peel is dried and crushed, then ultrasonically extracted with water under the action of a composite enzyme, and the product is inactivated, centrifuged, concentrated and dried to obtain the pomegranate peel extract.

[0043] The solid-liquid ratio is 1:30; the ultrasonic power is 450W, the water extraction time is 20min, and the water extraction temperature is 90°C; the complex enzyme is composed of pectinase, papain and neutral protease in a mass ratio of 1:3:3, and the addition amount of the complex enzyme is 5% of the mass of pomegranate peel.

[0044] The poplar mulberry linterus extract is a water extract of poplar mulberry linterus; the emulsifier is whey protein; the moisturizer is hyaluronic acid; and the thickener is caprylic / capric triglyceride.

[0045] Comparative Example 1 The antioxidant skin care product containing red ginseng extract proposed by the present invention comprises the following raw materials in parts by weight: 40 parts of red ginseng extract, 30 parts of pomegranate peel extract, 5 parts of emulsifier, 10 parts of moisturizer, 1 part of thickener, 2 parts of squalene, 3 parts of vitamin E, and 40 parts of water.

[0046] The components of the antioxidant skin care product are uniformly mixed and emulsified to obtain the antioxidant skin care product containing the red ginseng extract.

[0047] The steps of the preparation method of the red ginseng extract are as follows: the red ginseng is crushed and then ultrasonically extracted with alcohol under the action of a composite enzyme, and the product is inactivated, centrifuged, concentrated and dried to obtain the red ginseng extract.

[0048] The solvent for alcohol extraction is 70% ethanol, and the solid-liquid ratio is 1:15; the ultrasonic power is 300W, the alcohol extraction time is 45min, and the alcohol extraction temperature is 60℃; the complex enzyme is composed of cellulase and papain in a mass ratio of 1:1, and the addition amount of the complex enzyme is 2% of the mass of red ginseng.

[0049] The preparation method of the pomegranate peel extract comprises the following steps: the pomegranate peel is dried and crushed, then ultrasonically extracted with water under the action of a composite enzyme, and the product is inactivated, centrifuged, concentrated and dried to obtain the pomegranate peel extract.

[0050] The solid-liquid ratio is 1:20; the ultrasonic power is 400 W, the water extraction time is 30 min, and the water extraction temperature is 80°C; the complex enzyme is composed of pectinase, papain and neutral protease in a mass ratio of 1:1:1, and the addition amount of the complex enzyme is 3% of the mass of pomegranate peel.

[0051] The emulsifier is glyceryl stearate; the moisturizer is composed of hyaluronic acid and aloe extract in a mass ratio of 1:1; and the thickener is caprylic / capric triglyceride.

[0052] Comparative Example 2 The antioxidant skin care product containing red ginseng extract proposed by the present invention comprises the following raw materials in parts by weight: 40 parts of red ginseng extract, 30 parts of poplar mulberry linterus extract, 5 parts of emulsifier, 10 parts of moisturizer, 1 part of thickener, 2 parts of squalene, 3 parts of vitamin E, and 40 parts of water.

[0053] The components of the antioxidant skin care product are uniformly mixed and emulsified to obtain the antioxidant skin care product containing the red ginseng extract.

[0054] The steps of the preparation method of the red ginseng extract are as follows: the red ginseng is crushed and then ultrasonically extracted with alcohol under the action of a composite enzyme, and the product is inactivated, centrifuged, concentrated and dried to obtain the red ginseng extract.

[0055] The solvent for alcohol extraction is 70% ethanol, and the solid-liquid ratio is 1:15; the ultrasonic power is 300W, the alcohol extraction time is 45min, and the alcohol extraction temperature is 60℃; the complex enzyme is composed of cellulase and papain in a mass ratio of 1:1, and the addition amount of the complex enzyme is 2% of the mass of red ginseng.

[0056] The poplar mulberry linterus extract is a water extract of poplar mulberry linterus; the emulsifier is glyceryl stearate; the moisturizer is composed of hyaluronic acid and aloe extract in a mass ratio of 1:1; and the thickener is caprylic / capric triglyceride.

[0057] Comparative Example 3 The antioxidant skin care product containing red ginseng extract proposed by the present invention comprises the following raw materials in parts by weight: 35 parts of pomegranate peel extract, 35 parts of poplar mulberry linterus extract, 5 parts of emulsifier, 10 parts of moisturizer, 1 part of thickener, 2 parts of squalene, 3 parts of vitamin E, and 40 parts of water.

[0058] The components of the antioxidant skin care product are uniformly mixed and emulsified to obtain the antioxidant skin care product containing the red ginseng extract.

[0059] The steps of the preparation method of the pomegranate peel extract are as follows: the pomegranate peel is dried and crushed, then ultrasonically extracted with water under the action of a composite enzyme, and the product is inactivated, centrifuged, concentrated and dried to obtain the pomegranate peel extract.

[0060] The solid-liquid ratio is 1:20; the ultrasonic power is 400 W, the water extraction time is 30 min, and the water extraction temperature is 80°C; the complex enzyme is composed of pectinase, papain and neutral protease in a mass ratio of 1:1:1, and the addition amount of the complex enzyme is 3% of the mass of pomegranate peel.

[0061] The poplar mulberry linterus extract is a water extract of poplar mulberry linterus; the emulsifier is glyceryl stearate; the moisturizer is composed of hyaluronic acid and aloe extract in a mass ratio of 1:1; and the thickener is caprylic / capric triglyceride.

[0062] The antioxidant properties of the skin care products prepared in Examples 1-3 and Comparative Examples 1-3 were tested, and the test results are shown in Table 1.

[0063] The test method for scavenging DPPH free radicals is as follows: the antioxidant skin care products prepared in Examples 1-3 and Comparative Examples 1-3 are prepared into a sample solution with a concentration of 2% with anhydrous ethanol, and a 0.01 mmol / L DPPH test solution is prepared, 0.5 mL of the sample solution is added to the DPPH test solution, mixed thoroughly and allowed to stand in a dark place for 30 minutes, anhydrous ethanol is used as a blank control, and the absorbance is measured at 517 nm. The scavenging rate of each sample for DPPH is calculated according to the following formula: Wherein, A2 is the absorbance of the reaction system of antioxidant skin care products and DPPH; A1 is the absorbance of antioxidant skin care products and anhydrous ethanol; A0 is the absorbance of DPPH and anhydrous ethanol.

[0064] The test method for scavenging hydroxyl radicals is as follows: Examples 1-3 and Comparative Examples 1-3 are used as samples to be tested, 1 ml of FeSO4 (0.15 mmol / L), 0.4 ml of salicylic acid (2 mmol / L), 0.2 ml of the sample to be tested, 1 ml of H2O2 (6 mmol / L) and 0.4 ml of distilled water are added to the test tubes of the sample group; the blank group uses distilled water instead of the sample to be tested, and the control group uses distilled water instead of salicylic acid, and the reaction is carried out at 37°C for 30 minutes. Vc is used as a positive control, and each sample is measured in parallel 3 times and the average value is taken. The scavenging rate of each sample for hydroxyl radicals is calculated according to the following formula: The test method for superoxide anion scavenging ability is as follows: Examples 1-3 and Comparative Examples 1-3 are used as samples to be tested, 1 ml of the samples to be tested are added with 4.5 mL, 50 mmol / L Tris-HCl buffer solution with pH = 8.2, and then mixed. After keeping warm for 20 minutes, take out, immediately add 0.3 mL of 25 mmol / L pyrogallol solution, shake quickly and react in a 25°C constant temperature water bath for 5 minutes, then add 1 mL of HCl (8 mmol / L), mix and terminate the reaction, measure the absorbance at 325 nm, use distilled water instead of the sample as a blank control, use Vc as a positive control, and measure each sample in parallel 3 times to take the average value. The scavenging rate of each sample for superoxide anions is calculated according to the following formula: Where A3 is the average absorbance of the blank; A4 is the average absorbance of the sample to be tested.

[0065] Table 1 Antioxidant performance test results of samples

[0066] It can be seen from the test results of Examples 1-3 in Table 1 that the skin care products prepared by the present invention have excellent antioxidant properties, wherein the DPPH free radical scavenging rate is more than 95%, the hydroxyl free radical scavenging rate is more than 83%, and the superoxide anion scavenging rate is more than 82%. It can be seen from the test results of Example 1 and Comparative Examples 1-3 that the red ginseng extract, pomegranate peel extract and poplar mulberry linterus extract of the present invention have a synergistic effect in improving the antioxidant properties of skin care products. This is because the red ginseng extract, pomegranate peel extract and poplar mulberry linterus extract significantly improve the antioxidant properties of skin care products through the synergistic promotion of multiple pathways and multiple targets, and can more effectively scavenge free radicals, inhibit lipid peroxidation, enhance antioxidant enzyme activity, and maintain redox balance in cells, thereby exerting a stronger antioxidant effect.

[0067] The storage stability of the skin care products prepared in Examples 1-3 was measured. Referring to "Chapter 5 Microbiological Testing Methods" in the "Technical Specifications for Safety of Cosmetics", the microbial content of the skin care products prepared in Examples 1-3 at different storage periods was measured. The test results are shown in Table 2.

[0068] Table 2 Storage stability test results of samples

[0069] From the test results in Table 2, it can be seen that even without adding preservatives, the skin care products of the present invention still have no bacterial growth after being stored for 9 months, which shows that the skin care products prepared by the present invention have excellent storage stability. This is because the components added by the present invention also have antibacterial properties.

[0070] Although the embodiments of the present application have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present application. The scope of the present application is defined by the appended claims and their equivalents, and all shall be included in the scope of protection of the present application.

Claims

1. An antioxidant skin care product comprising red ginseng extract, characterized in that: The invention comprises the following raw materials in parts by weight: 25-35 parts of red ginseng extract, 15-25 parts of pomegranate peel extract, 15-25 parts of poplar mulberry linterus extract, 1-10 parts of emulsifier, 5-15 parts of moisturizer, 0.5-1.5 parts of thickener, 1-3 parts of squalene, 1-5 parts of vitamin E and 30-50 parts of water.

2. The antioxidant skin care product comprising red ginseng extract according to claim 1, characterized in that: The preparation method of the red ginseng extract comprises the following steps: the red ginseng is crushed, ultrasonically extracted with alcohol under the action of a composite enzyme, and the product is inactivated, centrifuged, concentrated and dried to obtain the red ginseng extract.

3. The antioxidant skin care product comprising red ginseng extract according to claim 2, characterized in that: The solvent for alcohol extraction is 70% ethanol, and the solid-liquid ratio is 1:10-20; Ultrasonic power 200-400W, alcohol extraction time 30-60min, alcohol extraction temperature 50-70℃; The complex enzyme is composed of cellulase and papain in a mass ratio of 2:1-4, and the added amount of the complex enzyme is 1-3% of the mass of the red ginseng.

4. The antioxidant skin care product comprising red ginseng extract according to claim 1, characterized in that: The preparation method of the pomegranate peel extract comprises the following steps: the pomegranate peel is dried and crushed, then ultrasonically extracted with water under the action of a composite enzyme, and the product is inactivated, centrifuged, concentrated and dried to obtain the pomegranate peel extract.

5. The antioxidant skin care product comprising red ginseng extract according to claim 4, characterized in that: The material-liquid ratio is 1:10-30; Ultrasonic power 350-450W, water extraction time 20-40min, water extraction temperature 70-90℃; The compound enzyme is composed of pectinase, papain and neutral protease in a mass ratio of 3:1-9:1-9, and the added amount of the compound enzyme is 1-5% of the mass of the pomegranate peel.

6. The antioxidant skin care product comprising red ginseng extract according to claim 1, characterized in that: The poplar mulberry linterus extract is a poplar mulberry linterus water extract or a poplar mulberry linterus alcohol extract.

7. The antioxidant skin care product comprising red ginseng extract according to claim 1, characterized in that: The emulsifier is one or more of sucrose stearate, glyceryl stearate, lecithin, sorbitan ester, polyglycerol ester and whey protein.

8. The antioxidant skin care product comprising red ginseng extract according to claim 1, characterized in that: The moisturizer is one or more of glycerin, hyaluronic acid, aloe extract, trehalose, olive oil and erythritol.

9. The antioxidant skin care product comprising red ginseng extract according to claim 1, characterized in that: The thickener is one or more of xanthan gum, carrageenan, sodium alginate and caprylic / capric triglyceride.

10. A method for preparing an antioxidant skin care product comprising red ginseng extract, the antioxidant skin care product being as claimed in any one of claims 1 to 9, characterized in that: The method comprises the following steps: uniformly mixing the components of the antioxidant skin care product, and then homogenizing and emulsifying the components to obtain the antioxidant skin care product containing the red ginseng extract.

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