Coating method of royal jelly freeze-dried powder, product and application of royal jelly freeze-dried powder, liver-nourishing capsule and preparation method of liver-nourishing capsule

Abstract

The invention belongs to the technical field of medicines, and particularly relates to a coating method of royal jelly freeze-dried powder, a product and application of the royal jelly freeze-dried powder, a liver-nourishing capsule and a preparation method of the liver-nourishing capsule. The coating method of the royal jelly freeze-dried powder comprises the following steps: S1, dissolving a coating material in a solvent to obtain a coating solution; S2, coating the royal jelly freeze-dried powder with the coating solution to obtain coated royal jelly freeze-dried powder; the coating material is prepared from hydroxypropyl methylcellulose, modified maltodextrin and isomaltitol. The liver-nourishing capsule prepared from the coated royal jelly freeze-dried powder provided by the invention has qualified moisture content under shady, cool, normal temperature and accelerated conditions, and the serious reduction of the content of the royal jelly freeze-dried powder is avoided.

Description

Technical Field

[0001] The invention belongs to the technical field of medicines, and specifically relates to a coating method of royal jelly freeze-dried powder and its product, application, liver nourishing capsule and its preparation method. Background Art

[0002] Yanggan Capsule is a Chinese patent medicine, composed of freeze-dried royal jelly powder, chicken gizzard lining, fragrant tea and camellia pollen. It is mainly used to soothe the liver and strengthen the spleen, replenish qi and activate blood circulation. It is used for fatigue, lethargy, loss of appetite, abdominal distension, loose stools, and hypochondria caused by liver depression and spleen deficiency with blood stasis. It is also suitable for the auxiliary treatment of patients with post-hepatitis cirrhosis with the above symptoms.

[0003] However, due to the presence of royal jelly freeze-dried powder, the liver-nourishing capsules are prone to deliquesce, resulting in the moisture content exceeding the control requirements of the national pharmacopoeia for capsules; in addition, there is also the problem that the content of royal jelly freeze-dried powder is easy to decrease during storage, which affects the product quality and drug efficacy.

[0004] At present, in order to avoid the above problems, expensive moisture-proof packaging with relatively good moisture-proof properties or additional aluminum foil moisture-proof bags and other measures are generally used to prevent moisture. However, these moisture-proof measures correspondingly increase production processes and costs, extend the production cycle, and reduce production efficiency.

[0005] The Chinese patent with the publication number CN1340343A discloses a method for manufacturing a low-hygroscopic royal jelly freeze-dried powder tablet. The technical solution is to coat the royal jelly freeze-dried powder with beeswax powder. The melting point of beeswax is generally low. When heated, the wax will melt and evenly coat the surface of the freeze-dried powder. Then when it drops back to the original temperature, the beeswax will solidify again, and the surface will shrink during the solidification process, so that the surface of the freeze-dried powder is tightly wrapped with a thin layer of wax-like substance; and because beeswax has the characteristics of being non-hydrophilic, non-adsorbent, non-charged, and having a smooth surface, the friction coefficient between the coated freeze-dried powder is extremely small, so the technical problem of the easy moisture absorption of royal jelly freeze-dried powder is perfectly solved, and the hygroscopicity of royal jelly freeze-dried powder can be greatly reduced. However, the coated freeze-dried powder with an extremely small friction coefficient may cause an increase in static electricity accumulation between powders during the preparation of liver-nourishing capsules, thereby causing powder aggregation or clogging. Summary of the invention

[0006] In view of the above problems, the present invention provides a coating method of royal jelly freeze-dried powder and its product, application, liver nourishing capsule and its preparation method.

[0007] To achieve the above purpose, the technical solution adopted by the present invention is as follows:

[0008] The first aspect of the present invention provides a method for coating royal jelly freeze-dried powder, comprising the following steps:

[0009] S1. Dissolve the coating material in a solvent to obtain a coating solution:

[0010] S2, coating the royal jelly freeze-dried powder with a coating liquid to obtain coated royal jelly freeze-dried powder;

[0011] The coating material includes hypromellose, modified maltodextrin and isomalt.

[0012] In some preferred embodiments, the mass ratio of the hydroxypropyl methylcellulose, modified maltodextrin, isomalt and solvent is 4-7:2-5:1:100.

[0013] There are many types of coating materials in the art, but not all coating materials are suitable for coating royal jelly freeze-dried powder. The applicant accidentally discovered during the experiment that when the coating materials are hydroxypropyl methylcellulose, modified maltodextrin and isomalt, the three can work together to not only ensure that the moisture content of the liver-nourishing capsules is qualified under cool and room temperature conditions, but also avoid a serious decrease in the content of the royal jelly freeze-dried powder.

[0014] The coated royal jelly freeze-dried powder prepared by the present invention is intended to be used for preparing liver-nourishing capsules, and the liver-nourishing capsules also contain camellia pollen, fragrant tea leaves and chicken's gizzard lining, so the coated royal jelly freeze-dried powder needs to be evenly mixed with the camellia pollen, fragrant tea leaves and chicken's gizzard lining. The applicant further finds that only when the mass ratio of hydroxypropyl methylcellulose, modified maltodextrin, isomalt and solvent is controlled to be 4-7:2-5:1:100, the mixture of the coated royal jelly freeze-dried powder, camellia pollen, fragrant tea leaves and chicken's gizzard lining has good mixing uniformity.

[0015] Further preferably, the mass ratio of the hydroxypropyl methylcellulose, modified maltodextrin, isomalt and solvent is 6:3:1:100.

[0016] In some preferred embodiments, the solvent includes at least one of water, ethanol and ethanol aqueous solution, preferably ethanol aqueous solution.

[0017] Preferably, the concentration of the ethanol aqueous solution is 40-60wt%, preferably 50wt%.

[0018] In some preferred embodiments, the method for preparing the modified maltodextrin comprises the following steps:

[0019] Step 1, dissolving sulfobutyl ether-β-cyclodextrin in water, and stirring to obtain sulfobutyl ether-β-cyclodextrin slurry;

[0020] Step 2: adding maltodextrin into sulfobutyl ether-β-cyclodextrin slurry to carry out stirring reaction, and drying, crushing and grinding after the stirring reaction to obtain modified maltodextrin.

[0021] The applicant unexpectedly discovered that when the modified maltodextrin obtained by modifying maltodextrin with sulfobutyl ether-β-cyclodextrin acts together with hydroxypropyl methylcellulose and isomalt, it can avoid the mixing uniformity of the mixture of coated royal jelly freeze-dried powder with camellia pollen, fragrant tea and chicken gizzard lining being unqualified and avoid the moisture content of the liver-nourishing capsule being unqualified under accelerated conditions. Although the modified maltodextrin obtained by modifying maltodextrin with hydroxypropyl-β-cyclodextrin or other excipients can make the moisture content of the liver-nourishing capsule qualified under cool and room temperature conditions, the moisture content is still unqualified under accelerated conditions.

[0022] In some preferred embodiments, the mass ratio of maltodextrin to sulfobutyl ether-β-cyclodextrin is 6-8:2-4.

[0023] Further preferably, the mass ratio of maltodextrin to sulfobutyl ether-β-cyclodextrin is 7:3.

[0024] In some preferred embodiments, the mass ratio of the sulfobutyl ether-β-cyclodextrin to water is 1:15-20, preferably 1:20.

[0025] In some preferred embodiments, the stirring speed in step 1 is 400-500 rpm.

[0026] In some preferred embodiments, the stirring reaction in step 2 has a rotation speed of 200-300 rpm, and a stirring reaction time of 30-60 min.

[0027] In some preferred embodiments, the coating process conditions in step S2 are: air inlet temperature is 42-54°C; fan frequency is 10-20Hz; liquid supply speed is 2-5rpm; tablet bed temperature is 38-40°C; and atomization pressure is 0.15-0.16MPa.

[0028] Further preferably, the inlet air temperature is 46-50°C.

[0029] In some preferred embodiments, the coating weight gain in step S2 is 10-30%.

[0030] The second aspect of the present invention provides coated royal jelly freeze-dried powder prepared by the above coating method.

[0031] The third aspect of the present invention provides the use of the coated royal jelly freeze-dried powder prepared by the above-mentioned preparation method in the preparation of drugs for soothing the liver and strengthening the spleen, and invigorating qi and promoting blood circulation.

[0032] The fourth aspect of the present invention provides a liver nourishing capsule, the raw materials of which include: coated royal jelly freeze-dried powder, chicken gizzard lining, fragrant tea herb and camellia pollen.

[0033] In some preferred embodiments, the raw materials of the liver nourishing capsule include 40-200 parts of coated royal jelly freeze-dried powder, 100-310 parts of camellia pollen, 10-80 parts of fragrant tea leaves, and 10-100 parts of chicken gizzard lining, by weight.

[0034] Preferably, the raw materials of the liver nourishing capsule include 80-120 parts of coated royal jelly freeze-dried powder, 180-260 parts of camellia pollen, 20-50 parts of fragrant tea leaves, and 20-60 parts of chicken gizzard lining, by weight.

[0035] Preferably, the raw materials of the liver nourishing capsule include, by weight, 100 parts of coated royal jelly freeze-dried powder, 40 parts of chicken gizzard lining, 32 parts of fragrant tea leaves, and 228 parts of camellia pollen.

[0036] The fifth aspect of the present invention provides a preparation method of liver nourishing capsules, comprising the following steps: taking half of the fragrant tea leaves, crushing them into fine powder, decocting the remaining fragrant tea leaves with water, filtering to obtain a filtrate, concentrating the filtrate into a thick paste, adding the fragrant tea leaves fine powder, mixing evenly, drying, and crushing into fine powder A; washing chicken gizzard lining, drying, and crushing into fine powder B; mixing fine powder A, fine powder B, coated royal jelly freeze-dried powder, camellia pollen, and starch evenly to obtain a mixture, and filling the mixture into capsules.

[0037] Preferably, the added amount of starch is 1-7% of the total mass of the fine powder A, the fine powder B, the coated royal jelly freeze-dried powder and the camellia pollen.

[0038] In some preferred embodiments, the preparation method of the liver-nourishing capsule comprises the following steps: taking half of the fragrant tea leaf, crushing it into fine powder, adding water to the remaining fragrant tea leaf and boiling it for 1-3 hours, filtering to obtain a filtrate, concentrating the filtrate to a thick paste with a relative density of 1.25-1.30 (60°C), adding the fragrant tea leaf fine powder, mixing well, drying at 60°C, and crushing into fine powder A; washing chicken gizzard lining, drying at 60°C, and crushing into fine powder B; mixing fine powder A, fine powder B, coated royal jelly freeze-dried powder, and camellia pollen evenly to obtain a mixture, and putting it into capsules.

[0039] It should be noted that the present invention does not specifically limit the capsule, including but not limited to gelatin capsule, hydroxypropyl cellulose capsule, pullulan and the like.

[0040] Compared with the prior art, the present invention has the following beneficial effects:

[0041] 1. The present invention adopts hydroxypropyl methylcellulose, modified maltodextrin and isomalt as coating materials. The three can work together to not only ensure that the moisture content of the liver-nourishing capsule is qualified under cool and room temperature conditions, but also avoid a serious decrease in the content of the royal jelly freeze-dried powder.

[0042] 2. When the mass ratio of hydroxypropyl methylcellulose, modified maltodextrin, isomalt and solvent is controlled to be 4-7:2-5:1:100, the mixture of coated royal jelly freeze-dried powder and camellia pollen, fragrant tea and chicken gizzard lining has good mixing uniformity.

[0043] 3. The modified maltodextrin obtained by modifying maltodextrin with sulfobutyl ether-β-cyclodextrin in the present invention acts together with hydroxypropyl methylcellulose and isomalt, thereby avoiding the unqualified mixing uniformity of the mixture of coated royal jelly freeze-dried powder and camellia pollen, fragrant tea and chicken gizzard lining and avoiding the unqualified moisture content of the liver-nourishing capsule under accelerated conditions. DETAILED DESCRIPTION

[0044] Various exemplary embodiments of the present invention will now be described in detail. This detailed description should not be considered as limiting the present invention, but should be understood as a more detailed description of certain aspects, features, and embodiments of the present invention.

[0045] It should be understood that the terms described in the present invention are only for describing special embodiments and are not intended to limit the present invention. In addition, for the numerical range in the present invention, it should be understood that each intermediate value between the upper and lower limits of the scope is also specifically disclosed. Each smaller range between the intermediate value in any stated value or stated range and any other stated value or intermediate value in the described range is also included in the present invention. The upper and lower limits of these smaller ranges can be independently included or excluded in the scope.

[0046] Unless otherwise indicated, all technical and scientific terms used herein have the same meanings as those generally understood by those skilled in the art. Although the present invention describes only preferred methods and materials, any methods and materials similar or equivalent to those described herein may also be used in the implementation or testing of the present invention. All documents mentioned in this specification are incorporated by reference to disclose and describe the methods and / or materials associated with the documents. In the event of a conflict with any incorporated document, the content of this specification shall prevail.

[0047] It will be apparent to those skilled in the art that various modifications and variations may be made to the specific embodiments of the present invention description without departing from the scope or spirit of the present invention. Other embodiments derived from the present invention description will be apparent to those skilled in the art. The present invention description and examples are exemplary only.

[0048] The words “include,” “including,” “have,” “contain,” etc. used in this document are open-ended terms, meaning including but not limited to.

[0049] Hydroxypropyl methylcellulose was obtained from Huzhou Zhanwang Pharmaceutical Co., Ltd., model: ZW-HPMC-2910-E6;

[0050] Maltodextrin comes from Shanghai Linchen Pharmaceutical Technology Co., Ltd., model: 17D;

[0051] Sulfonbutyl ether-β-cyclodextrin was from Shanghai Linchen Pharmaceutical Technology Co., Ltd., model: SBECD DEXOLVE;

[0052] Isomalt is from Shanghai Linchen Pharmaceutical Technology Co., Ltd., model: galenlQ TM 981.

[0053] Royal jelly freeze-dried powder comes from Beijing Yadong Biopharmaceutical Co., Ltd.

[0054] Microcrystalline cellulose was obtained from Shanghai Linchen Pharmaceutical Technology Co., Ltd., model: AVICEL PH-103;

[0055] Hydroxypropyl-β-cyclodextrin was obtained from Shandong Runxinda Chemical Co., Ltd.;

[0056] The capsule is a gelatin capsule from Suzhou Capsule Co., Ltd., with the trade name: Gelatin Capsule Coni-Snap.

[0057] The preparation methods of the modified maltodextrins of Examples 1-3 and Comparative Examples 1-5 are as follows:

[0058] Step 1, dissolving sulfobutyl ether-β-cyclodextrin in water, and stirring at a rotation speed of 450 rpm to obtain sulfobutyl ether-β-cyclodextrin slurry;

[0059] Step 2: adding maltodextrin to the sulfobutyl ether-β-cyclodextrin slurry and stirring the mixture at a rotation speed of 250 rpm for 40 minutes. After the stirring reaction, drying, crushing and grinding are performed to obtain modified maltodextrin.

[0060] The mass ratio of the maltodextrin to the sulfobutyl ether-β-cyclodextrin is 7:3.

[0061] The mass ratio of the sulfobutyl ether-β-cyclodextrin to water is 1:20.

[0062] Example 1-3, Comparative Example 1-7 Coated Royal Jelly Freeze-dried Powder

[0063] Example 1 Preparation of coated royal jelly freeze-dried powder, the steps are:

[0064] S1. Dissolve hydroxypropyl methylcellulose, modified maltodextrin and isomalt in a 50 wt% ethanol aqueous solution to prepare a coating solution:

[0065] S2. Coating the royal jelly freeze-dried powder with a coating liquid to increase the weight by 30% to obtain coated royal jelly freeze-dried powder.

[0066] The mass ratio of the hydroxypropyl methylcellulose, modified maltodextrin, isomalt and ethanol aqueous solution is 4:2:1:100.

[0067] The coating process conditions in step S2 are: inlet air temperature is 42°C; fan frequency is 10 Hz; liquid supply speed is 2 rpm; tablet bed temperature is 38°C; and atomization pressure is 0.15 MPa.

[0068] Example 2 Preparation of coated royal jelly freeze-dried powder, the steps are:

[0069] S1. Dissolve hydroxypropyl methylcellulose, modified maltodextrin and isomalt in a 50 wt% ethanol aqueous solution to prepare a coating solution:

[0070] S2. Coating the royal jelly freeze-dried powder with a coating liquid to increase the weight by 20% to obtain coated royal jelly freeze-dried powder.

[0071] The mass ratio of the hydroxypropyl methylcellulose, modified maltodextrin, isomalt and ethanol aqueous solution is 7:5:1:100.

[0072] The coating process conditions in step S2 are: air inlet temperature of 54°C; fan frequency of 20 Hz; liquid supply speed of 5 rpm; tablet bed temperature of 40°C; and atomization pressure of 0.16 MPa.

[0073] Example 3

[0074] The steps of preparing coated royal jelly freeze-dried powder are as follows:

[0075] S1. Dissolve hydroxypropyl methylcellulose, modified maltodextrin and isomalt in a 50 wt% ethanol aqueous solution to prepare a coating solution:

[0076] S2. Coating the royal jelly freeze-dried powder with a coating liquid to obtain a weight gain of 10% to obtain coated royal jelly freeze-dried powder.

[0077] The mass ratio of the hydroxypropyl methylcellulose, modified maltodextrin, isomalt and ethanol aqueous solution is 6:3:1:100.

[0078] The coating process conditions in step S2 are: air inlet temperature of 50°C; fan frequency of 15 Hz; liquid supply speed of 4 rpm; tablet bed temperature of 39°C; and atomization pressure of 0.16 MPa.

[0079] Comparative Example 1

[0080] The only difference from Example 3 is that hypromellose is replaced with microcrystalline cellulose of the same mass, and the rest is the same.

[0081] Comparative Example 2

[0082] The only difference from Example 3 is that isomalt is replaced with hydroxypropyl cellulose of the same mass, and the rest is the same.

[0083] Comparative Example 3

[0084] The only difference from Example 3 is that the modified maltodextrin is replaced with isomalt of equal mass, and the rest is the same.

[0085] Comparative Example 4

[0086] The only difference from Example 3 is that the mass ratio of the hypromellose, modified maltodextrin, isomalt and ethanol aqueous solution is 2:4:4:100, and the rest are the same.

[0087] Comparative Example 5

[0088] The only difference from Example 3 is that the mass ratio of the hypromellose, modified maltodextrin, isomalt and ethanol aqueous solution is 8:1:1:100, and the rest are the same.

[0089] Comparative Example 6

[0090] The only difference from Example 3 is that the preparation method of the modified maltodextrin is different. The preparation method of the modified maltodextrin is:

[0091] Step 1, dissolving hydroxypropyl-β-cyclodextrin in water, and stirring at a rotation speed of 450 rpm to obtain sulfobutyl ether-β-cyclodextrin slurry;

[0092] Step 2: Add maltodextrin into hydroxypropyl-β-cyclodextrin slurry and stir for reaction at a rotation speed of 250 rpm for 40 minutes. After the stirring reaction, dry, crush and grind to obtain modified maltodextrin.

[0093] The mass ratio of the maltodextrin to the hydroxypropyl-β-cyclodextrin is 7:3.

[0094] The mass ratio of the hydroxypropyl-β-cyclodextrin to water is 1:20; the rest are the same.

[0095] Comparative Example 7

[0096] The only difference from Example 3 is that the preparation method of the modified maltodextrin is different. The preparation method of the modified maltodextrin is:

[0097] Step 1, dissolving isomalt in water, and stirring at a rotation speed of 450 rpm to obtain isomalt slurry;

[0098] Step 2: adding maltodextrin to the isomalt slurry and stirring the mixture at a rotation speed of 250 rpm for 40 minutes. After the stirring reaction, drying, crushing and grinding are performed to obtain modified maltodextrin.

[0099] The mass ratio of maltodextrin to isomalt is 7:3.

[0100] The mass ratio of isomalt to water is 1:20; the rest are the same.

[0101] Application Examples

[0102] The compositions of the liver nourishing capsules of Application Examples 1-3 and Comparative Application Examples 1-8, in parts by mass, are shown in Table 1.

[0103] Table 1

[0104]

[0105]

[0106] The preparation method of the liver-nourishing capsule of Application Examples 1-3 and Comparative Application Examples 1-7 is as follows: take half of the fragrant tea leaves, grind it into fine powder, add water to the remaining fragrant tea leaves and boil it for 2 hours, filter it to obtain a filtrate, concentrate the filtrate to a thick paste with a relative density of 1.30 (60°C), add the fragrant tea leaves fine powder, mix well, dry it at 60°C, and grind it into fine powder A; wash the chicken's gizzard lining, dry it at 60°C, and grind it into fine powder B; mix the fine powder A, fine powder B, coated royal jelly freeze-dried powder, camellia pollen, and starch (the amount of starch added is 7.5% of the total mass of fine powder A, fine powder B, coated royal jelly freeze-dried powder and camellia pollen) evenly to obtain a mixture, and put it into capsules.

[0107] Test Example 1 Mixing Uniformity

[0108] The mixture obtained by uniformly mixing fine powder A, fine powder B, coated royal jelly freeze-dried powder of Examples 1-3 and Comparative Examples 1-7, camellia pollen and starch was tested for mixing uniformity. The testing method is: taking the mixture at 10 different positions after mixing, detecting the content, and calculating the RSD value based on the content result. The RSD value <5% is recorded as qualified. The results are shown in Table 2.

[0109] Test Example 2: Stability

[0110] The liver-nourishing capsules of Application Examples 1-3 and Comparative Application Examples 1-7 were respectively put into plastic bottles, and subjected to room temperature stability test, cool stability test and accelerated stability test. The moisture content and royal jelly freeze-dried powder content were determined according to the provisions of the 2020 edition of the Pharmacopoeia. The moisture content results are shown in Table 2, and the royal jelly freeze-dried powder content is shown in Table 3.

[0111] The conditions of the normal temperature stability test are: temperature 25℃±2℃, relative humidity 60%±10%;

[0112] The conditions of the cool stability test are: temperature 20℃±2℃, relative humidity 60%±10%;

[0113] The conditions for the accelerated stability test are: temperature 40°C ± 2°C, relative humidity 75% ± 5%.

[0114] Table 2

[0115]

[0116]

[0117] As can be seen from Table 2, the moisture content of the liver-nourishing capsules obtained in Application Examples 1-3 at room temperature, cool and accelerated conditions is less than 9%, which meets the requirements of the Pharmacopoeia. At the same time, the RSD value of the mixing uniformity of the mixture obtained by coating royal jelly freeze-dried powder and other raw materials is <5%, which meets the requirements of the Pharmacopoeia. However, due to the changes in the coating material components of Comparative Application Examples 1-3, the liver-nourishing capsules are unqualified at room temperature, cool or accelerated conditions; in Comparative Application Examples 4-5, the mass ratio of hydroxypropyl methylcellulose, modified maltodextrin, isomalt and solvent is not within the range of 4-7:2-5:1:100, and the mixing uniformity of the obtained coated royal jelly freeze-dried powder and other raw materials is unqualified; in Comparative Application Examples 6-7, due to the change in the preparation method of modified maltodextrin, the mixing uniformity of the obtained coated royal jelly freeze-dried powder and other raw materials is unqualified, and the moisture content of the liver-nourishing capsules under accelerated conditions is unqualified; in Comparative Application Example 8, uncoated royal jelly freeze-dried powder is directly used, and the moisture content of the liver-nourishing capsules obtained is unqualified at room temperature, cool and accelerated conditions.

[0118] Table 3

[0119]

[0120] It can be seen from Table 3 that the royal jelly freeze-dried powder content of the liver-nourishing capsules obtained in Application Examples 1-3 changes little under normal temperature, cool and accelerated conditions; while in Comparative Application Examples 1-3, due to the change in the coating material composition, the mass ratio of hydroxypropyl methylcellulose, modified maltodextrin, isomalt and solvent is not within the range of 4-7:2-5:1 in Application Examples 4-5, and the change in the preparation method of modified maltodextrin in Comparative Application Examples 6-7 is greater than that in Example 1-3; Comparative Application Example 8 directly uses uncoated royal jelly freeze-dried powder, and the royal jelly freeze-dried powder content of the liver-nourishing capsules obtained under normal temperature, cool and accelerated conditions is seriously reduced.

[0121] The above is a further description of the present invention in conjunction with specific embodiments, but these embodiments are merely exemplary and do not constitute any limitation on the scope of the present invention. It should be understood by those skilled in the art that the details and forms of the technical solution of the present invention may be modified or replaced without departing from the spirit and scope of the present invention, but these modifications and replacements all fall within the scope of protection of the present invention.

Claims

1. A method for coating royal jelly freeze-dried powder, characterized in that: The following steps are involved: S1. Dissolve the coating material in a solvent to obtain a coating solution: S2, coating the royal jelly freeze-dried powder with a coating liquid to obtain coated royal jelly freeze-dried powder; The coating material includes hypromellose, modified maltodextrin and isomalt.

2. The coating method according to claim 1, characterized in that The mass ratio of the hydroxypropyl methylcellulose, modified maltodextrin, isomalt and solvent is 4-7:2-5:1:

100.

3. The coating method according to claim 2, characterized in that The mass ratio of the hydroxypropyl methylcellulose, modified maltodextrin, isomalt and solvent is 6:3:1:

100.

4. The coating method according to claim 3, characterized in that The preparation method of the modified maltodextrin comprises the following steps: Step 1, dissolving sulfobutyl ether-β-cyclodextrin in water, and stirring to obtain sulfobutyl ether-β-cyclodextrin slurry; Step 2: adding maltodextrin into sulfobutyl ether-β-cyclodextrin slurry to carry out stirring reaction, and drying, crushing and grinding after the stirring reaction to obtain modified maltodextrin.

5. The coating method according to claim 4, characterized in that: The mass ratio of the maltodextrin to the sulfobutyl ether-β-cyclodextrin is 6-8:2-4.

6. The coating method according to claim 5, characterized in that: The mass ratio of the maltodextrin to the sulfobutyl ether-β-cyclodextrin is 7:

3.

7. The coating method according to claim 1, characterized in that: The coating process conditions in step S2 are: air inlet temperature of 42-54°C; fan frequency of 10-20Hz; liquid supply speed of 2-5rpm; tablet bed temperature of 38-40°C; and atomization pressure of 0.15-0.16MPa.

8. The coating method according to claim 7, characterized in that: The inlet air temperature is 46-50°C.

9. The coated royal jelly freeze-dried powder prepared by the coating method according to any one of claims 1 to 8.

10. Use of the coated royal jelly freeze-dried powder prepared by the coating method according to any one of claims 1 to 8 or the coated royal jelly freeze-dried powder according to claim 9 in preparing drugs for soothing the liver and strengthening the spleen, and invigorating qi and promoting blood circulation.

11. A liver nourishing capsule, characterized in that: The raw materials include: coated royal jelly freeze-dried powder obtained by the coating method according to any one of claims 1 to 8, chicken gizzard lining, fragrant tea plant and camellia pollen.

12. The liver nourishing capsule according to claim 11, characterized in that: The raw materials of the liver nourishing capsule include 40-200 parts of coated royal jelly freeze-dried powder, 100-310 parts of camellia pollen, 10-80 parts of fragrant tea leaves, and 10-100 parts of chicken gizzard lining, calculated by weight.

13. The liver nourishing capsule according to claim 12, characterized in that: Calculated by weight, the raw materials include 80-120 parts of coated royal jelly freeze-dried powder, 180-260 parts of camellia pollen, 20-50 parts of fragrant tea leaves, and 20-60 parts of chicken gizzard lining.

14. The liver nourishing capsule according to claim 13, characterized in that: The liver nourishing capsules include, by weight, 100 parts of coated royal jelly freeze-dried powder, 40 parts of chicken gizzard lining, 32 parts of fragrant tea leaves, and 228 parts of camellia pollen.

15. The method for preparing the liver nourishing capsule according to any one of claims 11 to 14, characterized in that: The following steps are involved: Take half of the fragrant tea leaves and grind them into fine powder, add water to the remaining fragrant tea leaves and boil them, filter them to obtain a filtrate, concentrate the filtrate into a thick paste, add the fragrant tea leaves fine powder, mix well, dry, and grind them into fine powder A; wash the chicken's gizzard lining, dry, and grind them into fine powder B; mix the fine powder A, fine powder B, coated royal jelly freeze-dried powder, camellia pollen, and starch evenly to obtain a mixture, and put it into capsules.

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