Ultrasonic applying method and ultrasonic thrombolysis equipment

Abstract

The invention discloses an ultrasonic applying method and ultrasonic thrombolysis equipment, and relates to the technical field of ultrasonic thrombolysis, and the ultrasonic applying method comprises the following steps: S1, body position adjustment; s2, radiography positioning; s3, carrying out in-vitro thrombolysis; and S4, intravascular thrombolysis. The device further comprises a bed body, a positioning assembly, an ultrasonic assembly and an electric control system. Through the arrangement of the positioning assembly, the ultrasonic assembly and the electric control system, free positioning of the ultrasonic transducer is achieved, and through phase / frequency modulation of the ultrasonic transducer, a focus is formed and the thrombus position is dynamically tracked; in an in-vitro thrombolysis mode, a plurality of groups of transducers are matched to form a superposed ultrasonic field; while stagnation points are eliminated, the cavitation effect is enhanced, and thermal damage is avoided; in an intravascular thrombolysis mode, an upstream transducer enables a stationary point to move towards thrombus through frequency sweeping, and the drug carrier is pushed to be released in a targeted manner; a downstream transducer generates high-frequency short pulses to form a sound trap, large fragments are captured through secondary sound radiation force, and meanwhile low-frequency continuous waves promote further dissolution of tiny fragments.

Description

Technical Field

[0001] The present invention relates to the technical field of ultrasonic thrombolysis, and in particular to an ultrasonic application method and an ultrasonic thrombolysis device. Background Art

[0002] Ultrasonic thrombolysis is a treatment method that uses ultrasonic technology to dissolve blood clots. It is mainly used to treat blood clots in blood vessels and restore blood flow. It destroys blood clots through the mechanical, cavitation and thermal effects of ultrasound. The operation methods include in vitro and intravascular methods. During the treatment, real-time imaging monitoring is required, and if necessary, combined with drug thrombolysis to improve the efficacy.

[0003] After searching, the Chinese patent with publication number CN116585002A, the method includes: applying multiple ultrasonic waves of different frequencies around it simultaneously and / or sequentially through one or more ultrasonic transducers, so that the positions of the stationary points formed by the ultrasonic interference of the multiple ultrasonic waves of different frequencies are different. The device includes one or more ultrasonic transducers, which are configured to apply multiple ultrasonic waves of different frequencies around it simultaneously and / or sequentially, so that the positions of the stationary points formed by the ultrasonic interference of the multiple ultrasonic waves of different frequencies are different. The above scheme can make the ultrasonic field intensity distribution more uniform, dynamically control the stationary point position by changing the ultrasonic frequency, thereby completing the directional delivery of thrombolytic drugs and reducing the adverse effects of the stationary point on thrombosis treatment.

[0004] However, in the above scheme, in which the ultrasonic frequency applied by a single ultrasonic transducer at different times is changed to control the stagnation point position to complete the directional drug delivery, the change of the ultrasonic frequency is jumpy. At this time, the stagnation point position changes in a jumpy manner. When the new stagnation point is close to the upstream side of the original stagnation point, the drug may be pulled back to the upstream direction under the influence of the acoustic flow. On the other hand, in the above scheme, in the process of eliminating the stagnation point by applying a superimposed ultrasonic field through multiple ultrasonic transducers, when the frequencies of the second and third ultrasonic waves are greater than the frequency of the first ultrasonic wave, the acoustic flow direction generated by them is opposite to the acoustic flow direction of the first ultrasonic wave, and their acoustic radiation force is greater than the acoustic radiation force generated by the first ultrasonic wave. At this time, the drug may be pushed back and stay at the position of the first ultrasonic wave, making it difficult to achieve the expected directional delivery effect. Summary of the invention

[0005] The purpose of the present invention is to provide an ultrasound application method and an ultrasound thrombolysis device, which have the advantages of targeted drug delivery, precise thrombolysis and large fragment interception, and solve the problems raised in the background technology.

[0006] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: an ultrasound application method, comprising the following steps: S1, body position adjustment; S2, angiography positioning; S3, in vitro thrombolysis; S4, intravascular thrombolysis.

[0007] S1. Body position adjustment: Place the patient on the bed and fix him with a restraint belt, then use the electric control system to control the bed and the adjustment shaft to rotate synchronously, and adjust the patient's thrombus position to the center of the semicircular guide rail;

[0008] S2. Angiography positioning: The electronic control system controls the transverse movement mechanism to move the ultrasonic component to the same level as the thrombus. Then the telescopic mechanism is activated to drive the ultrasonic component to extend toward the center of the semicircular guide rail until the ultrasonic component is against the patient's skin surface. At this time, the angiography module performs real-time imaging of the thrombus. According to the imaging results, the positioning component is further fine-tuned so that the ultrasonic transducer accurately corresponds to the thrombus position.

[0009] S3, in vitro thrombolysis: turn on the ultrasound component, adjust the ultrasound frequency in real time through the electronic control system, ultrasound transducer 1 provides the basic ultrasound field, ultrasound transducer 2 and ultrasound transducer 3 realize the dynamic tracking of the thrombus position by the acoustic focus through phase / frequency modulation, and adapt to the vascular pulsation or displacement;

[0010] S4. Intravascular thrombolysis: Ultrasonic transducer 2 and ultrasonic transducer 3 are delivered into the blood vessel through interventional catheter and puncture surgery. Ultrasonic transducer 2 moves the standing wave node formed by acoustic radiation force toward the thrombus through frequency sweeping, promoting the targeted release of drug carriers. Ultrasonic transducer 3 generates high-frequency short pulses to form an acoustic trap, capturing large fragments through secondary acoustic radiation force, while low-frequency continuous waves promote further dissolution of tiny fragments.

[0011] Preferably, an ultrasonic thrombolysis device comprises a bed, a positioning component, an ultrasonic component and an electric control system, wherein the bed is penetrated and fixedly connected with an adjustment shaft, a plurality of restraint belts are arranged on the upper surface of the bed, both ends of the adjustment shaft extend out of the bed and penetrate the bed frame, and the adjustment shaft is driven by an external motor and connected with the electric control system signal;

[0012] The positioning assembly includes a transverse movement mechanism for controlling the horizontal position of the ultrasonic assembly and a telescopic mechanism for controlling the positioning angle of the ultrasonic assembly, the transverse movement mechanism includes a screw rod penetrating through the two opposite sides of the two bed frames, the telescopic mechanism includes an electric push rod fixedly connected to the transverse movement mechanism, the electric push rod is driven by an external motor and is connected to the electronic control system signal;

[0013] The ultrasound component includes an imaging module that cooperates with an external display to realize a real-time imaging function and a correction mechanism that controls the acoustic focus position of the ultrasound component. The correction mechanism includes a worm that is rotationally connected to the telescopic mechanism.

[0014] Preferably, the screw rods are provided in two groups and are distributed in mirror symmetry along the central axis of the bed. The screw rods are driven by an external motor and are connected to the electronic control system signal. A transverse ring is screwed on the outer contour of the middle section of each screw rod, and a semicircular guide rail is fixedly connected between the axial same sides of the outer contours of the two transverse rings. A slider is slidably connected between the two semicircular guide rails, and the outer contours of the two screw rods extending out of one end of the bed frame are meshingly connected with the same synchronous chain.

[0015] Preferably, a clamp for limiting the movement of the slider is provided at the sliding connection between the slider and the semicircular guide rail, and the clamp of the slider is set to be normally open and connected to the signal of the electric control system.

[0016] Preferably, the electric push rod is fixedly connected to the upper surface of the slider, and a telescopic part extending downward is provided inside the electric push rod. The telescopic part passes through the slider, and the bottom end of the telescopic part is fixedly connected to a fixing plate, and one side of the fixing plate is fixedly connected to two brackets symmetrically distributed up and down.

[0017] Preferably, the worm penetrates through and is connected to the two brackets for limited rotation. The worm is driven by an external motor and is connected to the electronic control system signal. The outer contours on both sides of the worm are meshingly connected with worm wheels. The axes of the two worm wheels are fixedly connected with transmission shafts, and the transmission shafts penetrate the brackets. The outer contours of the two transmission shafts away from the worm wheels are fixedly connected with swing rods. The swing rods are located inside the brackets and are slidably connected to the brackets. The other end of the swing rod is provided with a buckle.

[0018] Preferably, the imaging module is fixedly connected to the lower surface of the bracket, an ultrasonic transducer 1 is arranged at the center of the lower surface of the imaging module, and the ultrasonic transducer 2 and the ultrasonic transducer 3 are detachably connected to the buckles of the two swing arms.

[0019] Preferably, the electric control system is configured to control the motion stroke of the positioning component and the sound wave frequency of the ultrasonic component according to the personnel input parameters;

[0020] In the intravascular thrombolysis mode, ultrasonic transducer 2 is always located on the upstream side of the thrombus, and ultrasonic transducer 3 is always located on the downstream side of the thrombus. In the in vitro thrombolysis mode, ultrasonic transducer 1, ultrasonic transducer 2 and ultrasonic transducer 3 cooperate with each other in the same frequency / difference frequency and maintain interference conditions through dynamic phase compensation.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] 1. The present invention realizes the free positioning of the ultrasonic transducer by setting a positioning component, an ultrasonic component and an electronic control system. Through the phase / frequency modulation of the ultrasonic transducer, an acoustic focus is formed and the position of the thrombus is dynamically tracked to achieve precise thrombolysis.

[0023] 2. In the in vitro thrombolysis mode, a superimposed ultrasonic field is formed by the cooperation of multiple groups of ultrasonic transducers; while eliminating the adverse effects of stagnation points on thrombus treatment, the cavitation effect is enhanced to destroy the fibrin network, while avoiding thermal damage to healthy tissues caused by high frequency.

[0024] 3. In the intravascular thrombolysis mode, the upstream transducer moves the standing wave node formed by the acoustic radiation force toward the thrombus by frequency sweeping, thereby promoting the targeted release of the drug carrier; the downstream transducer generates high-frequency short pulses to form an acoustic trap, capturing large fragments through secondary acoustic radiation force, while the low-frequency continuous wave promotes further dissolution of tiny fragments. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 It is a schematic diagram of the main structure of the present invention;

[0026] Figure 2 It is a cross-sectional view of the main structure of the present invention;

[0027] Figure 3 It is a schematic diagram of the bed structure of the present invention;

[0028] Figure 4 It is a schematic diagram of the transverse movement mechanism of the present invention;

[0029] Figure 5 It is a schematic diagram of the connection relationship between the transverse movement mechanism and the telescopic mechanism of the present invention;

[0030] Figure 6 It is a schematic diagram of the connection relationship between the telescopic mechanism and the correction mechanism of the present invention;

[0031] Figure 7 It is a schematic diagram of the connection relationship between the telescopic mechanism and the ultrasonic component of the present invention;

[0032] Figure 8 It is a schematic diagram of the correction mechanism of the present invention;

[0033] Fig. 9 It is the overall workflow diagram of the present invention.

[0034] In the figure: 1. bed body; 11. adjustment shaft; 12. restraint belt; 13. bed frame; 2. screw; 21. synchronous chain; 22. transverse ring; 23. semicircular guide rail; 24. slider; 3. electric push rod; 31. telescopic part; 32. fixed plate; 33. bracket; 4. worm; 41. worm wheel; 42. transmission shaft; 43. swing rod; 5. angiography module; 51. ultrasonic transducer one; 52. ultrasonic transducer two; 53. ultrasonic transducer three. DETAILED DESCRIPTION

[0035] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0036] Embodiment 1:

[0037] See also Figures 1 to 9 The present invention provides a technical solution: an ultrasound application method, comprising the following steps: S1, body position adjustment; S2, angiography positioning; S3, in vitro thrombolysis; S4, intravascular thrombolysis.

[0038] S1, body position adjustment: the patient is placed on the bed 1 and fixed by the restraint belt 12, and then the bed 1 and the adjustment shaft 11 are controlled to rotate synchronously by the electric control system to adjust the thrombus position of the patient to the center of the semicircular guide rail 23;

[0039] S2, imaging positioning: the electric control system controls the transverse movement mechanism to move the ultrasonic component to the same horizontal position as the thrombus, and then the telescopic mechanism is activated to drive the ultrasonic component to extend toward the center of the semicircular guide rail 23 until the ultrasonic component is against the patient's skin surface. At this time, the imaging module 5 performs real-time imaging of the thrombus, and further fine-tunes the positioning component according to the imaging result, so that the ultrasonic transducer 51 accurately corresponds to the thrombus position;

[0040] S3, extracorporeal thrombolysis: turn on the ultrasonic component, adjust the ultrasonic frequency in real time through the electronic control system, ultrasonic transducer 1 51 provides a basic ultrasonic field, ultrasonic transducer 2 52 and ultrasonic transducer 3 53 realize dynamic tracking of the thrombus position by the acoustic focus through phase / frequency modulation, and adapt to the vascular pulsation or displacement;

[0041] S4. Intravascular thrombolysis: Ultrasonic transducer 2 52 and ultrasonic transducer 3 53 are delivered into the blood vessel through an interventional catheter in conjunction with a puncture procedure. Ultrasonic transducer 2 52 moves the standing wave node formed by the acoustic radiation force toward the thrombus by frequency sweeping, thereby promoting the targeted release of the drug carrier. Ultrasonic transducer 3 53 generates high-frequency short pulses to form an acoustic trap, which captures large fragments through secondary acoustic radiation force, while low-frequency continuous waves promote further dissolution of tiny fragments.

[0042] An ultrasonic thrombolysis device comprises a bed 1, a positioning component, an ultrasonic component and an electric control system. The bed 1 is penetrated and fixedly connected with an adjustment shaft 11. A plurality of restraint belts 12 are arranged on the upper surface of the bed 1. Both ends of the adjustment shaft 11 extend out of the bed 1 and penetrate a bed frame 13. The adjustment shaft 11 is driven by an external motor and is connected to the electric control system signal.

[0043] The positioning assembly includes a transverse movement mechanism for controlling the horizontal position of the ultrasonic assembly and a telescopic mechanism for controlling the positioning angle of the ultrasonic assembly. The transverse movement mechanism includes a screw rod 2 that passes through the two opposite sides of the two bed frames 13. The telescopic mechanism includes an electric push rod 3 that is fixedly connected to the transverse movement mechanism. The electric push rod 3 is driven by an external motor and is connected to the electronic control system signal.

[0044] The ultrasound component includes an imaging module 5 that cooperates with an external display to achieve a real-time imaging function and a correction mechanism that controls the acoustic focus position of the ultrasound component. The correction mechanism includes a worm 4 that is rotationally connected to the telescopic mechanism.

[0045] The ultrasonic thrombolysis equipment described in this plan includes two working modes: extracorporeal thrombolysis and intravascular thrombolysis. The mode can be selected according to the patient's condition. The extracorporeal thrombolysis mode is suitable for deep / superficial large thrombi or non-invasive priority scenarios, and the intravascular thrombolysis mode is suitable for acute embolism, small blood vessels, and high-risk detached thrombi.

[0046] Before the thrombolysis work begins, the thrombolysis mode to be used is determined based on the previous analysis of the condition, and the thrombus position is adjusted to the center through body position adjustment. Then the positioning component starts working and accurately positions the ultrasonic component. The positioned ultrasonic component is pressed against the skin surface at the thrombus.

[0047] In the in vitro thrombolysis mode, the ultrasonic transducer 1 51 , the ultrasonic transducer 2 52 and the ultrasonic transducer 3 53 simultaneously output ultrasonic waves. At this time, the corresponding frequency range needs to be selected according to the patient's thrombus distribution location and type.

[0048] The sound wave frequency range of the ultrasonic transducer 51 is set to 1.0-1.8MHz. The SAR of 1-1.8MHz in muscle is <100W / kg, which is within the safe range of thermal controllability. At the same time, the cavitation threshold is the lowest near 1MHz, about 0.5MPa, which can efficiently produce inertial cavitation and improve the effect of bubble collapse in destroying fibrin. Among them, the frequency range of 1.0-1.2MHz is mainly suitable for deep thrombosis, such as the deep veins of the lower limbs, with a penetration depth of 6-10cm. At this frequency, the cavitation effect is significant due to the fibrin rupture threshold of about 0.8MPa. The frequency range of 1.5-1.8MHz is mainly suitable for superficial thrombosis, such as the carotid artery, with a penetration depth of 3-5cm. The focus is sharper at this frequency, and its effect on thrombus fragmentation is stronger.

[0049] Furthermore, the frequency range of ultrasonic transducer 2 52 and ultrasonic transducer 3 53 is set to 1.2-2.0MHz, and phase / frequency modulation is performed according to the type of thrombus; for fresh thrombus, ultrasonic transducer 2 52, ultrasonic transducer 3 53 and ultrasonic transducer 1 51 are set to difference frequency coordination, for example, ultrasonic transducer 1 51 adopts 1.0MHz, and ultrasonic transducer 2 52 and ultrasonic transducer 3 53 are 1.1MHz. At this time, the superimposed ultrasonic field generates 100kHz low-frequency mechanical waves, which can enhance the internal shear force of the thrombus to improve the thrombolytic effect of the scheme; and for old thrombus, ultrasonic transducer 2 52, ultrasonic transducer 3 53 and ultrasonic transducer 1 51 are set to the same frequency and phase, for example, ultrasonic transducer 1 51 is 1.8MHz, and ultrasonic transducer 2 52 and ultrasonic transducer 3 53 are 2.0MHz. At this time, the sound pressure at the focus is maximized, which can effectively increase the fragmentation effect of the thrombus.

[0050] It should be noted that during the above-mentioned phase / frequency modulation process, there is blood vessel pulsation or thrombus displacement, and the position of the thrombus moves. Therefore, it is necessary to dynamically control the phase / frequency of ultrasonic transducer 2 52 and ultrasonic transducer 3 53 to achieve frequency scanning to move the focus, so as to ensure that the focus is always aligned with the thrombus and thus achieve the effect of precise thrombolysis; the phase / frequency modulation process of ultrasonic transducer 2 52 and ultrasonic transducer 3 53 is realized by a correction mechanism and an electronic control system.

[0051] In the intravascular thrombolysis mode, ultrasonic transducer 1 51 does not participate in the work, and only ultrasonic transducer 2 52 and ultrasonic transducer 3 53 output ultrasonic waves. At this time, the frequency range of ultrasonic transducer 2 52 is set to 800kHz-1.2MHz, and the frequency range of ultrasonic transducer 3 53 is set to alternating switching of 3-4MHz short pulses and 300-500kHz continuous waves.

[0052] Among them, the 800kHz–1.2MHz of ultrasonic transducer two 52 can form a stable standing wave node, and the wavelength is ≈1.9mm, which effectively matches the blood vessel diameter of 2–6mm. At this time, the thrombolytic drug molecules are retained at the stationary point, and then the stationary point is moved by sweeping the frequency, and the drug microbubbles move slowly toward the thrombus synchronously to achieve a targeted delivery effect; at the same time, the 3–4MHz short pulse of ultrasonic transducer three 53 can generate a strong acoustic radiation force, thereby intercepting thrombus fragments >200μm during the thrombolysis process. Large-sized thrombus fragments continue to be retained and further dissolved under the action of the acoustic field of ultrasonic transducer one 51, and the cavitation threshold of the 300–500kHz continuous wave is lower, which can further promote the cavitation disintegration of tiny fragments, thereby fully improving the thrombolytic effect of the scheme.

[0053] It should be noted that the low-frequency range setting of ultrasonic transducer two 52 and ultrasonic transducer three 53 can safely drive the stationary point to move and reduce damage to the blood vessel wall, but the specific frequency selection of ultrasonic transducer two 52 and the high and low frequency cycle of ultrasonic transducer three 53 need to match the blood flow velocity in the patient's blood vessels to prevent the drug microbubbles from being washed away or the thrombus fragments from escaping; at the same time, the short duty cycle of the high-frequency interception pulse of ultrasonic transducer three 53 needs to ensure that the temperature rise is <2°C to avoid thermal damage to the vascular endothelium, and the interception time should be ≤5 seconds to avoid complete blockage of blood flow. At this time, the size of the thrombus fragments after low-frequency dissolution of 52 is <50μm, which can be naturally cleared by macrophages.

[0054] Embodiment 2:

[0055] The screw rods 2 are provided in two groups and are distributed in a mirror-symmetrical manner along the central axis of the bed body 1. The screw rods 2 are driven by an external motor and are connected to the electronic control system signal. A transverse ring 22 is screwed on the outer contour of the middle section of each screw rod 2. A semicircular guide rail 23 is fixedly connected between the axial same sides of the outer contours of the two transverse guide rings 22. A slider 24 is slidably connected between the two semicircular guide rails 23. The outer contours of the two screw rods 2 extending out of one end of the bed frame 13 are meshingly connected with the same synchronous chain 21.

[0056] Preferably, a clamp for limiting the movement of the slider 24 is provided at the sliding connection between the slider 24 and the semicircular guide rail 23, and the clamp of the slider 24 is set to be normally open and connected to the electric control system signal.

[0057] The electric push rod 3 is fixedly connected to the upper surface of the slider 24. A telescopic portion 31 extending downward is provided inside the electric push rod 3. The telescopic portion 31 passes through the slider 24. A fixing plate 32 is fixedly connected to the bottom end of the telescopic portion 31. One side of the fixing plate 32 is fixedly connected to two brackets 33 symmetrically distributed up and down.

[0058] It can be seen from Example 1 that after the body position is adjusted, it is necessary to control the positioning component to position the ultrasonic component. At this time, the electronic control system drives the screw rod 2 to rotate. The two screw rods 2 have the same rotation amplitude and direction under the restriction of the synchronous chain 21. At this time, the two transverse rings 22 drive the semicircular guide rails 23 to move along the axial direction of the screw rod 2. The direction of rotation of the transverse ring 22 and the semicircular guide rail 23 can be adjusted by controlling the rotation direction of the screw rod 2, and the position of the semicircular guide rail 23 is made to correspond to the position of the thrombus. At this time, the screw rod 2 is stopped and the position of the semicircular guide rail 23 is fixed.

[0059] Then, the slider 24 is manually moved to slide along the semicircular guide rail 23 to a position suitable for operation. During the sliding process of the slider 24, due to the shape limitation of the semicircular guide rail 23, the bottom end of the slider 24 always points to the center of the semicircular guide rail 23. Since the center of the semicircular guide rail 23 is the thrombus position, the direction of the ultrasonic component always points to the thrombus position.

[0060] Furthermore, after the position of the slider 24 is adjusted, the clamp of the slider 24 is closed through the electronic control system. At this time, the slider 24 cannot continue to slide along the semicircular guide rail 23, that is, the position of the slider 24 is fixed; the clamp can adopt a pneumatic normally open type, which belongs to the existing technology and is not described in detail.

[0061] Embodiment three:

[0062] The worm 4 passes through and is connected to the two brackets 33 for limited rotation. The worm 4 is driven by an external motor and is connected to the electronic control system signal. The outer contours on both sides of the worm 4 are meshingly connected with worm wheels 41. The axes of the two worm wheels 41 are fixedly connected with transmission shafts 42. The transmission shafts 42 pass through the brackets 33. The outer contours of the two transmission shafts 42 away from the worm wheels 41 are fixedly connected with swing rods 43. The swing rods 43 are located inside the brackets 33 and are slidably connected to the brackets 33. The other end of the swing rods 43 is provided with a buckle.

[0063] The imaging module 5 is fixedly connected to the lower surface of the bracket 33, and an ultrasonic transducer 1 51 is arranged at the center of the lower surface of the imaging module 5. The buckles of the two swing rods 43 are detachably connected with an ultrasonic transducer 2 52 and an ultrasonic transducer 3 53 respectively.

[0064] Preferably, the electric control system is configured to control the motion stroke of the positioning component and the sound wave frequency of the ultrasonic component according to the personnel input parameters;

[0065] In the intravascular thrombolysis mode, ultrasonic transducer 2 52 is always located on the upstream side of the thrombus, and ultrasonic transducer 3 53 is always located on the downstream side of the thrombus. In the in vitro thrombolysis mode, ultrasonic transducer 1 51 and ultrasonic transducer 2 52 and ultrasonic transducer 3 53 are coordinated in the same frequency / difference frequency and the interference condition is maintained through dynamic phase compensation.

[0066] Furthermore, after the position of the slider 24 is fixed, the electric control system starts the electric push rod 3, and the telescopic part 31 gradually extends downward from the inside of the electric push rod 3 and drives the fixed plate 32 and the ultrasonic component to descend synchronously as a whole. Since the telescopic part 31 always points to the center of the semicircular guide rail 23, the fixed plate 32 and the ultrasonic component as a whole gradually approach the thrombus synchronously; when the ultrasonic component at the bottom end of the fixed plate 32 contacts the skin surface at the thrombus, the electric push rod 3 stops working. At this time, the position of the ultrasonic component is fixed, and the angiography module 5 starts real-time imaging to facilitate personnel to observe the precise position of the thrombus, and according to the thrombus position in the imaging structure, the position of the ultrasonic component is further fine-tuned through the positioning component to ensure that the ultrasonic transducer 51 accurately corresponds to the thrombus.

[0067] In the in vitro thrombolysis mode, ultrasonic transducer one 51, ultrasonic transducer two 52 and ultrasonic transducer three 53 simultaneously output ultrasonic waves. Based on the frequency range selection logic introduced in the first embodiment, an appropriate frequency range is selected for ultrasonic transducer one 51, ultrasonic transducer two 52 and ultrasonic transducer three 53 according to the distribution position and type of the patient's thrombus, and the imaging module 5 is used to display in real time the superimposed sound field waveform formed by the interference between ultrasonic transducer one 51, ultrasonic transducer two 52 and ultrasonic transducer three 53, wherein the superposition point of the peak / trough is the focus, where the sound pressure is the largest, and by adjusting the frequency and phase difference between ultrasonic transducer two 52 and ultrasonic transducer three 53 and ultrasonic transducer one 51, constructive interference is formed at the thrombus position to superimpose the amplitude, and other areas are offset to reduce tissue damage to effectively improve the thrombolytic effect of the scheme, and by fine-tuning the frequency or phase difference, the focus position / shape is adjusted in real time to adapt to the vascular pulsation or thrombus displacement.

[0068] When the phase of ultrasonic transducer 2 52 and ultrasonic transducer 3 53 needs to be adjusted, the electronic control system drives the worm 4 to rotate, and the worm 4 further drives the two worm wheels 41 to rotate. At this time, the two transmission shafts 42 rotate synchronously and drive the swing rod 43 to deflect, while the ultrasonic transducer 2 52 and ultrasonic transducer 3 53 located at the other end of the swing rod 43 revolve synchronously with the worm wheel 41 as the axis, and the ultrasonic transducer 2 52 and ultrasonic transducer 3 53 revolve in opposite directions.

[0069] When ultrasonic transducer 2 52 and ultrasonic transducer 3 53 revolve synchronously, the emission position of their ultrasonic waves changes synchronously, that is, the phase of ultrasonic transducer 2 52 and ultrasonic transducer 3 53 changes and a phase difference appears between them and ultrasonic transducer 1 51. At this time, the focal position of the superimposed sound field between ultrasonic transducer 2 52 and ultrasonic transducer 3 53 and ultrasonic transducer 1 51 changes in real time. The real-time imaging of the thrombus by the angiography module 5 is used to analyze the pulsation cycle of the blood vessel and the displacement cycle of the thrombus, and the amplitude of the movement of the thrombus with which the focus must be accompanied is determined. By controlling the rotation of the worm 4 according to the analyzed parameters, the focus and the thrombus can be kept in constant correspondence, thereby achieving the effect of precise thrombolysis.

[0070] It should be noted that the frequencies of ultrasonic transducer 1 51, ultrasonic transducer 2 52 and ultrasonic transducer 3 53 change continuously during the frequency scanning process, that is, the position change of the stagnation point / focus is also continuous, thereby avoiding the failure of positioning and capturing thereof due to the jump change of the stagnation point / focus position.

[0071] Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to the embodiments without departing from the principles and spirit of the present invention, and that the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An ultrasonic application method, characterized in that: The following steps are involved: S1. Body position adjustment; S2, angiographic positioning; S3, in vitro thrombolysis; S4. Intravascular thrombolysis.

2. An ultrasonic application method according to claim 1, characterized in that: The S1, body position adjustment, comprises placing the patient on the bed (1) and fixing the patient with a restraining belt (12), and then controlling the bed (1) and the adjustment shaft (11) to rotate synchronously through an electric control system to adjust the patient's thrombus position to the center of the semicircular guide rail (23); The S2, imaging positioning includes the electronic control system controlling the transverse movement mechanism to move the ultrasonic component to the same horizontal position as the thrombus, and then the telescopic mechanism is activated to drive the ultrasonic component to extend toward the center of the semicircular guide rail (23) until the ultrasonic component is against the patient's skin surface. At this time, the imaging module (5) performs real-time imaging of the thrombus, and further fine-tunes the positioning component according to the imaging result, so that the ultrasonic transducer 1 (51) accurately corresponds to the thrombus position; The S3, extracorporeal thrombolysis, includes turning on the ultrasonic component, adjusting the ultrasonic frequency in real time through the electronic control system, the ultrasonic transducer 1 (51) provides a basic ultrasonic field, and the ultrasonic transducer 2 (52) and the ultrasonic transducer 3 (53) realize the dynamic tracking of the thrombus position by the acoustic focus through phase / frequency modulation to adapt to the vascular pulsation or displacement; The S4, intravascular thrombolysis, includes delivering ultrasonic transducer 2 (52) and ultrasonic transducer 3 (53) into the blood vessel through an interventional catheter in conjunction with a puncture operation. Ultrasonic transducer 2 (52) moves the standing wave node formed by the acoustic radiation force toward the thrombus by frequency sweeping, thereby promoting the targeted release of the drug carrier. Ultrasonic transducer 3 (53) generates high-frequency short pulses to form an acoustic trap, and captures large fragments through secondary acoustic radiation force. At the same time, low-frequency continuous waves promote further dissolution of small fragments.

3. An ultrasonic thrombolysis device, applied to an ultrasonic application method according to any one of claims 1 to 2, characterized in that: The invention comprises a bed body (1), a positioning component, an ultrasonic component and an electric control system. The bed body (1) is penetrated by and fixedly connected with an adjustment shaft (11). The upper surface of the bed body (1) is provided with a plurality of restraint belts (12). Both ends of the adjustment shaft (11) extend out of the bed body (1) and penetrate a bed frame (13). The adjustment shaft (11) is driven by an external motor and is connected to the electric control system signal. The positioning assembly comprises a transverse movement mechanism for controlling the horizontal position of the ultrasonic assembly and a telescopic mechanism for controlling the positioning angle of the ultrasonic assembly, the transverse movement mechanism comprises a screw rod (2) penetrating through two opposite sides of two bed frames (13), the telescopic mechanism comprises an electric push rod (3) fixedly connected to the transverse movement mechanism, the electric push rod (3) is driven by an external motor and is connected to the signal of the electric control system; The ultrasound component comprises an imaging module (5) that cooperates with an external display to realize a real-time imaging function and a correction mechanism that controls the acoustic focus position of the ultrasound component, wherein the correction mechanism comprises a worm (4) that is rotationally connected to the telescopic mechanism in a limited position.

4. The ultrasonic thrombolysis device according to claim 3, characterized in that: The screw rods (2) are provided in two groups and are distributed in a mirror-symmetrical manner along the central axis of the bed body (1). The screw rods (2) are driven by an external motor and are connected to the signal of the electronic control system. A transverse ring (22) is screwed on the outer contour of the middle section of each screw rod (2). A semicircular guide rail (23) is fixedly connected between the axial same sides of the outer contours of the two transverse guide rings (22). A slider (24) is slidably connected between the two semicircular guide rails (23). The outer contours of the two screw rods (2) extending out of one end of the bed frame (13) are meshingly connected to the same synchronous chain (21).

5. The ultrasonic thrombolysis device according to claim 4, characterized in that: A clamp for limiting the movement of the slider (24) is provided at the sliding connection between the slider (24) and the semicircular guide rail (23); the clamp of the slider (24) is set to be normally open and connected to the signal of the electric control system.

6. The ultrasonic thrombolysis device according to claim 3, characterized in that: The electric push rod (3) is fixedly connected to the upper surface of the slider (24); a telescopic portion (31) extending downward is provided inside the electric push rod (3); the telescopic portion (31) passes through the slider (24); a fixing plate (32) is fixedly connected to the bottom end of the telescopic portion (31); and one side of the fixing plate (32) is fixedly connected to two brackets (33) symmetrically distributed up and down.

7. The ultrasonic thrombolysis device according to claim 3, characterized in that: The worm (4) penetrates and is connected to the two brackets (33) in a limited rotational manner. The worm (4) is driven by an external motor and is connected to the electronic control system signal. The outer contours on both sides of the worm (4) are meshingly connected to worm wheels (41). The axes of the two worm wheels (41) are fixedly connected to transmission shafts (42). The transmission shafts (42) penetrate the brackets (33). The outer contours of the two transmission shafts (42) away from the worm wheels (41) are fixedly connected to swing rods (43). The swing rods (43) are located inside the brackets (33) and are slidably connected to the brackets (33). The other end of the swing rods (43) is provided with a buckle.

8. The ultrasonic thrombolysis device according to claim 3, characterized in that: The imaging module (5) is fixedly connected to the lower surface of the bracket (33), and an ultrasonic transducer 1 (51) is arranged at the center of the lower surface of the imaging module (5). The buckles of the two swing rods (43) are respectively detachably connected to ultrasonic transducer 2 (52) and ultrasonic transducer 3 (53).

9. The ultrasonic thrombolysis device according to claim 8, characterized in that: The electric control system is configured to control the movement stroke of the positioning component and the sound wave frequency of the ultrasonic component according to the personnel input parameters; In the intravascular thrombolysis mode, ultrasonic transducer 2 (52) is always located on the upstream side of the thrombus, and ultrasonic transducer 3 (53) is always located on the downstream side of the thrombus. In the in vitro thrombolysis mode, ultrasonic transducer 1 (51) and ultrasonic transducer 2 (52) and ultrasonic transducer 3 (53) are in the same frequency / difference frequency coordination and maintain interference conditions through dynamic phase compensation.

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