Acne-removing composition applicable to sensitive skin and capable of regulating diet metabolism and application of acne-removing composition

Abstract

The invention discloses an acne-removing composition applicable to sensitive skin and capable of regulating diet metabolism and application of the acne-removing composition, and relates to the technical field of cosmetics. The invention provides an acne-removing composition for regulating diet metabolism. The composition comprises a component A and a component B, wherein the component A is prepared from the following components in parts by weight: 0.1 to 0.5 part of radix rehmanniae extract and 0.01 to 0.2 part of radix peucedani extract; the component B is prepared from the following ingredients in parts by weight: 0.005 to 0.3 part of 10-hydroxydecanoic acid, 0.0005 to 0.008 part of anthocyanin and 0.5 to 3 parts of guaiacol extracts. According to the acne-removing composition capable of regulating diet metabolism, proper parts by weight of the radix rehmanniae extract, the radix peucedani extract, the 10-hydroxydecanoic acid, the anthocyanin and the guaiacol extract are added, and the five components can cooperate with one another, so that water-oil balance can be regulated, pores can be dredged, a skin barrier can be repaired, and IGF-1 induced acne can be improved and prevented.

Description

Technical Field

[0001] The invention relates to the technical field of cosmetics, in particular to an anti-acne composition for regulating dietary metabolism suitable for sensitive skin and application thereof. Background Art

[0002] Acne is a very common chronic inflammatory or non-inflammatory skin disease in clinical practice. The site of onset is usually in areas with a high density of hair follicles and sebaceous glands, such as the face, chest, neck, and back. Typical acne manifestations include non-inflammatory skin lesions, such as blackheads, and inflammatory skin lesions, such as pustules, papules, or nodules. Insulin-like growth factor (IGF)-1 plays a vital role in the onset of acne. Studies have shown that the level of IGF-1 in the peripheral blood of acne patients is elevated, especially under the influence of Western dietary habits, which promotes the production of IGF-1, induces sebum secretion, causes pore blockage, aggravates inflammation, and stimulates the development of acne.

[0003] At present, the existing products for improving acne have the following shortcomings: (1) Ignoring the impact of dietary factors on acne: A high-oil and high-fat diet will aggravate acne, and by increasing the activity of insulin and IGF-1, it participates in the proliferation of keratinocytes, sebaceous gland cells and fat formation. However, the existing ingredients for improving the impact of dietary metabolism on the skin need to be further explored. (2) Existing ingredients have safety risks: for non-inflammatory acne, there are salicylic acid, benzoyl peroxide, azelaic acid, vitamin A, etc., while for inflammatory acne, antibiotics or other antibacterial measures are required. Acne treatment drugs have certain skin side effects and irritation, causing skin flaking, pigmentation and sensitivity.

[0004] In view of this, this application is filed. Summary of the invention

[0005] Based on this, the purpose of the present invention is to overcome the shortcomings of the above-mentioned prior art and provide an acne-removing composition for regulating dietary metabolism suitable for sensitive skin and its application.

[0006] To achieve the above-mentioned purpose, the technical solution adopted by the present invention is: an anti-acne composition for regulating dietary metabolism, the composition comprising component A and component B: component A comprises the following ingredients in parts by weight: 0.1-0.5 parts of Rehmannia glutinosa extract and 0.01-0.2 parts of Peucedanum pekinensis extract; component B comprises the following ingredients in parts by weight: 0.005-0.3 parts of 10-hydroxydecanoic acid, 0.0005-0.008 parts of anthocyanins, and 0.5-3 parts of guaiac extract.

[0007] Rehmannia root is one of the commonly used bulk medicinal materials. It is mainly produced in Henan, Hebei, Shaanxi and other places. Its main components are iridoids, ionones, triterpenes, etc. It has multiple pharmacological activities such as immunomodulation and anti-aging. Rehmannia root extract regulates the immune system, enhances the immune defense ability of the skin, and prevents external harmful factors (such as bacteria and ultraviolet rays) from damaging the skin; Peucedanum purpurogenum was included in the 2010 edition of the Chinese Pharmacopoeia as a new medicinal material. Modern pharmacological studies have shown that the main active ingredients in Peucedanum purpurogenum are coumarin compounds, which have anti-neurasthenia, anticoagulation, antioxidant, antibacterial, anticancer and other pharmacological activities. Hydroxydecanoic acid is an important moisturizer in the field of cosmetics. It can increase the water content of the skin, improve the moisture and elasticity of the skin. In addition, it also has antioxidant and antibacterial effects, plays an anti-aging effect on the skin, and protects the skin from bacterial infection; anthocyanin, as a natural antioxidant ingredient, has been widely used in the field of cosmetics. Its multiple functions such as anti-oxidation, anti-inflammatory, whitening, anti-aging and moisturizing make it an important ingredient in various skin care products, anti-aging products and sensitive skin care products; Guaiac wood is widely used in traditional medicine, especially in the treatment of skin diseases. Guaiac wood is rich in antioxidant ingredients, which can effectively remove free radicals in the body. It can help restore the skin barrier and promote the self-repair of the skin. It can accelerate cell renewal, improve skin metabolism, and enhance the skin's self-protection ability. When the skin is damaged, guaiac wood can accelerate the repair and healing process of the damaged area and reduce the formation of scars.

[0008] The inventors found in actual research that Rehmannia root extract can be used as the antibacterial, anti-inflammatory, oil-control and dietary factor regulating performance of the composite system, and the addition of Peucedanum purpurogenum extract can enhance these effects. After the combination is used, the prepared composition has better effects in regulating water-oil balance, unclogging pores, repairing skin barrier, and improving and preventing acne. 10-Hydroxydecanoic acid can be used as the antibacterial, anti-inflammatory and oil-control regulating factor of the composite system, and anthocyanins and guaiac extract can enhance this effect. After the coordinated use, the prepared composition has better effects in regulating water-oil balance, unclogging pores, repairing skin barrier, and improving and preventing acne.

[0009] The inventors found in actual research that the acne-removing composition for regulating dietary metabolism of the present invention selects to add appropriate weight portions of Rehmannia glutinosa extract, Peucedanum purpurogenum extract, 10-hydroxydecanoic acid, anthocyanin, and Guaiac wood extract, and the five components can cooperate with each other, thereby being able to regulate water-oil balance, unclog pores, repair skin barriers, and improve and prevent acne induced by IGF-1. The composition provided by the present invention can reduce the content of insulin-like growth factor IGF-1, block the transmission of downstream dietary signals, effectively regulate the secretion of sebum, and reduce the release of cellular inflammatory factors; the composition provided by the present invention can unclog pores, reduce the formation of acne, and prevent the occurrence and development of acne; the composition provided by the present invention can effectively improve the skin repair ability, prevent the appearance of acne marks and acne pits, and improve the overall health of the skin.

[0010] Preferably, the component A comprises the following ingredients in parts by weight: 0.15-0.25 parts of Rehmannia glutinosa extract and 0.05-0.15 parts of Peucedanum pekinensis extract; the component B comprises the following ingredients in parts by weight: 0.04-0.1 parts of 10-hydroxydecanoic acid, 0.001-0.005 parts of anthocyanins and 0.8-1.5 parts of Guaiac wood extract.

[0011] The inventors found in actual research that the weight of the components in the composition provided by the present invention will affect the performance of the product. When the weight of the components is further selected to be within the above range, the obtained product has better effects of regulating water-oil balance, unclogging pores, repairing skin barrier, and improving and preventing acne induced by IGF-1.

[0012] Preferably, the weight ratio of component A to component B is: component A: component B = (0.2-0.4): (1-1.5).

[0013] Preferably, in the component A, the weight percentage of the Rehmannia glutinosa extract is 60-70%.

[0014] Preferably, in the component B, the weight percentage of 10-hydroxydecanoic acid is 4.5-7.5%.

[0015] The inventors found in actual research that the weight ratio of component A to component B in the composition provided by the present invention, the weight percentage of the Rehmannia glutinosa extract in component A, and the weight percentage of 10-hydroxydecanoic acid in component B will affect the performance of the product. When the components are further selected within the above range, the obtained product has better effects of regulating water-oil balance, unclogging pores, repairing skin barrier, and improving and preventing acne induced by IGF-1.

[0016] Preferably, the preparation method of the Rehmannia root extract is: drying, crushing and sieving Rehmannia root to obtain coarse Rehmannia root powder, then adding ethanol solution for ultrasonic extraction, filtering, concentrating and drying the extract to obtain the Rehmannia root extract.

[0017] Preferably, the volume fraction of the ethanol is 40-90%; further preferably, the volume fraction of the ethanol is 50-60%.

[0018] Preferably, the mesh size of the sieving is 200-400 meshes.

[0019] Preferably, the weight ratio of the ethanol solution to the Rehmannia glutinosa powder is 8-12:1; and / or the temperature of the ultrasonic extraction is 30-60°C, the time of the ultrasonic extraction is 20-60min, and the number of extractions is 1-3 times.

[0020] The inventors found in actual research that when the Rehmannia glutinosa extracts prepared by different extraction methods are added to the anti-acne composition for regulating dietary metabolism, the efficacy of the anti-acne composition for regulating dietary metabolism will be different. When the preparation method is selected as above, the comprehensive effect of the obtained composition is better.

[0021] In addition, the present invention provides the use of the anti-acne composition for regulating dietary metabolism in the preparation of skin products.

[0022] Preferably, the skin products include any one of lotion, emulsion, ointment, cream, mask, essence and spray.

[0023] Furthermore, the present invention provides a skin product, which comprises the anti-acne composition for regulating dietary metabolism.

[0024] Preferably, the skin product comprises the following components in percentage by mass: 1-3% of the anti-acne composition for regulating dietary metabolism, 3-40% of the matrix in the skin product, and the balance being water.

[0025] Preferably, the matrix in the skin product includes at least one of a thickener, a moisturizer, an emulsifier, a preservative, a fragrance, and a pH adjuster.

[0026] Preferably, the skin product comprises the following components in percentage by mass: 1-3% of the anti-acne composition for regulating dietary metabolism, 0.05-0.5% of a thickener, 3-20% of a moisturizer, 0.5-10% of an emulsifier, 0.2-5% of a preservative, 0.01-0.2% of a flavor, 0.05-0.1% of a pH adjuster, and the remainder is water.

[0027] Exemplarily, the thickener includes at least one of xanthan gum, carbomer 980, AVC, and high molecular weight cellulose; the moisturizer includes at least one of glycerin, butylene glycol, and low molecular weight sodium hyaluronate; the emulsifier includes at least one of coconut oil alcohol-caprylate / caprate, polydimethylsiloxane, hydrogenated palm kernel oil, cetearyl alcohol, polyglyceryl-6 distearate, and polymethylsilsesquioxane; the preservative includes at least one of 1,3-propylene glycol, 1,2-hexanediol, and parahydroxyacetophenone; the pH adjuster includes at least one of arginine and EDTA-2Na.

[0028] Compared with the prior art, the beneficial effects of the present invention are as follows: the inventors found in actual research that the Rehmannia root extract can be used as the antibacterial, anti-inflammatory, oil-controlling and dietary factor IGF-1 regulating performance of the composite system, and the addition of the Peucedanum pekinensis extract can enhance these effects. After being used in combination, the prepared composition has better effects of regulating water-oil balance, unclogging pores, repairing skin barrier, and improving and preventing acne induced by IGF-1. 10-Hydroxydecanoic acid can be used as the antibacterial, anti-inflammatory and oil-controlling regulating factor of the composite system, and anthocyanins and guaiac extract can enhance this effect. After being used in combination, the prepared composition has better effects of regulating water-oil balance, unclogging pores, repairing skin barrier, and improving and preventing acne induced by IGF-1. The inventors found in actual research that the acne-removing composition for regulating dietary metabolism of the present invention selects to add appropriate weight portions of Rehmannia glutinosa extract, Peucedanum purpurogenum extract, 10-hydroxydecanoic acid, anthocyanin, and Guaiac wood extract, and the five components can cooperate with each other, thereby being able to regulate water-oil balance, unclog pores, repair skin barriers, and improve and prevent acne induced by IGF-1. The composition provided by the present invention can reduce the content of insulin-like growth factor IGF-1, block the transmission of downstream dietary signals, effectively regulate the secretion of sebum, and reduce the release of cellular inflammatory factors; the composition provided by the present invention can unclog pores, reduce the formation of acne, and prevent the occurrence and development of acne; the composition provided by the present invention can effectively improve the skin repair ability, prevent the appearance of acne marks and acne pits, and improve the overall health of the skin. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 The figures are pictures showing the improvement effect of facial acne on a human body before and after 14 days of using the products of Application Example 1 and Comparative Application Example 1; wherein, Figure (a) is a picture showing the improvement effect of facial acne on a human body before and after 14 days of using the products of Application Example 1, and Figure (b) is a picture showing the improvement effect of facial acne on a human body before and after 14 days of using the products of Comparative Application Example 1;

[0030] Figure 2The figures are the improvement effect pictures of human facial pores before and after 14 days of using the products of Application Example 1 and Comparative Application Example 1; wherein, Figure (c) is the improvement effect picture of human facial pores before and after 14 days of using the products of Application Example 1, and Figure (d) is the improvement effect picture of human facial pores before and after 14 days of using the products of Comparative Application Example 1. DETAILED DESCRIPTION

[0031] In order to better illustrate the purpose, technical scheme and advantages of the present invention, the present invention will be further described below in conjunction with the accompanying drawings and specific embodiments. Its purpose is to understand the content of the present invention in detail, rather than to limit the present invention. All other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention. Unless otherwise specified, the experimental reagents and instruments designed for the implementation and comparative examples of the present invention are all commonly used ordinary reagents and instruments, which can be obtained from commercial channels. In the implementation and comparative examples, the experimental methods used are conventional methods unless otherwise specified; and unless otherwise specified, the raw materials used in parallel experiments are the same batch of raw materials.

[0032] The raw materials of the present invention are described below, but are not limited to the following raw materials:

[0033] Peucedanum purpurogenum extract: purchased from Shaanxi Snotech Biotechnology Co., Ltd.;

[0034] 10-Hydroxydecanoic acid: purchased from Beijing Solaibao Technology Co., Ltd.;

[0035] Anthocyanin: purchased from Shanghai Yuanye Biotechnology Co., Ltd.;

[0036] Guaiac wood extract: purchased from Shanghai Yien Chemical Technology Co., Ltd.;

[0037] Peucedanum peucedanum extract: purchased from Nanjing Puyi Biotechnology Co., Ltd.;

[0038] Aloe vera extract: purchased from Anhui Bensentang Biotechnology Co., Ltd.;

[0039] Anthocyanins: purchased from Shanghai Aladdin Biochemical Technology Co., Ltd.

[0040] Calendula officinalis extract: purchased from Guangzhou Meiyi Biotechnology Co., Ltd.;

[0041] Rehmannia extract-1: Homemade, the preparation method is as follows: dry and crush Rehmannia in an oven at 60°C, pass through a 300-mesh sieve to obtain Rehmannia coarse powder, then add ethanol solution for ultrasonic extraction, filter, concentrate and dry the extract to obtain Rehmannia extract; the volume fraction of ethanol is 50%, the weight ratio of ethanol solution to Rehmannia coarse powder is 8:1, the extraction time is 30 minutes, the ultrasonic extraction temperature is 40°C, and the number of extractions is 2 times.

[0042] Rehmannia extract-2: Homemade, the preparation method is as follows: dry and crush Rehmannia in an oven at 60°C, and pass through a 300-mesh sieve to obtain Rehmannia coarse powder; then add ethanol solution for ultrasonic extraction, filter, concentrate and dry the extract to obtain Rehmannia extract; the volume fraction of ethanol is 60%, the weight ratio of ethanol solution to Rehmannia coarse powder is 12:1, the extraction time is 60 minutes, the ultrasonic extraction temperature is 60°C, and the number of extractions is 2 times.

[0043] Rehmannia glutinosa extract-3: homemade, compared with Rehmannia glutinosa extract-1, only the volume fraction of ethanol is different, which is 90%.

[0044] Rehmannia glutinosa extract-4: homemade, compared with Rehmannia glutinosa extract-1, only the volume fraction of ethanol is different, which is 40%.

[0045] Rehmannia root extract: homemade, the preparation method is as follows: take Rehmannia root, dry and crush it in a 60℃ oven, and pass it through a 300-mesh sieve to obtain Rehmannia root coarse powder; add water to moisten it according to a solid-liquid ratio of 10:4, then dry it at 60℃ and steam it in a steamer at normal pressure to obtain Rehmannia root powder after steaming for 12 hours; then add ethanol solution to the Rehmannia root powder for ultrasonic extraction, filter it, concentrate and dry the extract to obtain Rehmannia root extract; the volume fraction of ethanol is 50%, the weight ratio of ethanol solution to Rehmannia root powder is 8:1, the extraction time is 30 minutes, the extraction temperature is 40℃, and the number of ultrasonic extractions is 2 times.

[0046] The HPLC method was used to determine the verbascoside content of different Rehmannia glutinosa extracts. The results showed that the verbascoside content of Rehmannia glutinosa extracts 1-4 was 0.85%, 0.80%, 0.53% and 0.33%, respectively, and the verbascoside content of the Rehmannia glutinosa extract was 0.03%.

[0047] Examples and Comparative Examples

[0048] The present invention provides an anti-acne composition for regulating dietary metabolism in the embodiments and comparative examples. The components and weight portions of the anti-acne composition for regulating dietary metabolism are selected as shown in Tables 1 and 2. The preparation method of the anti-acne composition for regulating dietary metabolism comprises the following steps:

[0049] The extract of Rehmannia root, the extract of Peucedanum peucedanum, 10-hydroxydecanoic acid, anthocyanin and the extract of Guaiacum officinale are fully and evenly mixed by ultrasonication to obtain the anti-acne composition for regulating dietary metabolism.

[0050] Table 1

[0051]

[0052]

[0053] Table 2

[0054]

[0055]

[0056] Application Examples

[0057] The application examples of the present invention provide an emulsion, and the components (mass percentage) of the emulsion are shown in Table 3, wherein the anti-acne composition for regulating dietary metabolism in Application Examples 1-9 respectively uses the anti-acne composition for regulating dietary metabolism prepared in Examples 1-9, and the anti-acne composition for regulating dietary metabolism in Comparative Application Examples 1-9 respectively uses the anti-acne composition for regulating dietary metabolism prepared in Comparative Examples 1-9; for example, the anti-acne composition for regulating dietary metabolism used in Application Example 1 is the anti-acne composition for regulating dietary metabolism prepared in Example 1, the anti-acne composition for regulating dietary metabolism used in Application Example 2 is the anti-acne composition for regulating dietary metabolism prepared in Example 2, the anti-acne composition for regulating dietary metabolism used in Application Example 10 is the anti-acne composition for regulating dietary metabolism prepared in Example 1, and the anti-acne composition for regulating dietary metabolism used in Comparative Application Example 1 is the anti-acne composition for regulating dietary metabolism prepared in Comparative Example 1, and the same can be said for others.

[0058] Table 3

[0059]

[0060] The preparation method of the emulsion provided in Application Example 1 is as follows:

[0061] (1) Mix phase A and water, heat to 80° C., and homogenize at 1200 rpm for 5 min. After homogenization, keep the mixture warm for later use to obtain prefabricated phase A;

[0062] (2) Mix phase B, heat to 80° C., and homogenize at 1200 rpm for 5 min. After homogenization, keep warm for later use to obtain prefabricated phase B;

[0063] (3) Mix phase C and heat to 60°C to melt to obtain prefabricated phase C;

[0064] (4) The preformed phase A is heated to 80°C, and the preformed phase B is added at a speed of 300 rpm, and stirred and mixed. Then, the temperature is lowered to 60°C, and the preformed phase C is added at a speed of 300 rpm and stirred and mixed. Then, the temperature is lowered to below 45°C, and the composition and flavor are added, and stirring is continued for 5 minutes. Finally, arginine is added to adjust the pH to 5.0-6.5, and stirring can be stopped. The material is discharged to obtain an emulsion.

[0065] The preparation methods of the emulsions provided in the remaining application examples, comparative application examples and blank application examples are consistent with that in application example 1, and no relevant components are added if there are no relevant components.

[0066] Effect Example 1 Sebaceous Gland Cell Vitality Test

[0067] This effect example explores the inhibitory effect of the anti-acne composition for regulating dietary metabolism prepared in the examples and comparative examples on IGF-1-induced sebocyte proliferation.

[0068] Experimental materials: The cell line is human sebaceous gland cells (SZ95, passage: P7); the culture medium is a sodium pyruvate-free DMEM culture medium containing 10% FBS; the culture conditions are 37°C, 5% CO2, and saturated humidity. The concentration of MTT solution is 5 mg / mL.

[0069] Experimental steps: The model group was treated with IGF-1 (20ng / ml) for 6 hours before the SZ95 embryonic cells were exposed to the culture medium for 72 hours; the sample group was treated with IGF-1 for 6 hours before the cells were exposed to different compositions (concentration of 1.5%) for 72 hours; the blank control group was cultured for 72 hours without IGF-1 and the composition. After the culture was completed, 20μL MTT solution was added to each well, cultured for 3-4 hours, the liquid in the well was removed, 100μL DMSO was added to each well, placed on an oscillator for 10 minutes, and the absorbance was measured at 570nm on a microplate reader.

[0070] Inhibition rate (%) = (cell viability of model group - cell viability of sample group) / cell viability of model group × 100%.

[0071] The test results are shown in Table 4.

[0072] Table 4

[0073]

[0074]

[0075] Note: Compared with the model group, significance is indicated by *, P value < 0.05 is indicated by *, P value < 0.01 is indicated by **, P value < 0.001 is indicated by ***, and no significance, P value > 0.05 is indicated by ns.

[0076] Promoting sebocyte apoptosis can not only reduce sebum secretion, but also prevent excessive inflammatory response. Studies have shown that IGF-1 promotes sebaceous cell proliferation and differentiation, inhibits apoptosis, thereby inducing excessive sebum secretion and promoting the development of acne. The anti-acne composition for regulating dietary metabolism prepared by the present invention has a strong inhibitory effect on IGF-1.

[0077] From the comparison of Examples 1-9, it can be seen that the weight proportions of the components will affect the comprehensive effect of the composition for regulating dietary metabolism to improve acne. When the weight proportions of the components are further selected within a preferred range, the obtained acne-removing composition for regulating dietary metabolism has a stronger inhibitory effect on IGF-1-induced sebaceous gland cell proliferation.

[0078] From the comparison of Example 1 and Comparative Examples 1-9, it can be seen that the five components of the anti-acne composition for regulating dietary metabolism of the present invention, namely, Rehmannia root extract, Peucedanum pekinensis extract, 10-hydroxydecanoic acid, anthocyanin, and Guaiacum officinale extract, can cooperate with each other and none of them is indispensable.

[0079] Effect Example 2 Anti-inflammatory Test

[0080] This effect example explores the anti-inflammatory effect of the acne-removing composition for regulating dietary metabolism prepared in the examples and comparative examples.

[0081] 1. Experimental materials: Cell line: mouse macrophages (RAW264.7), source: Cell Resource Center, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, fetal bovine serum (FBS, Gibco), DMEM high glucose medium (DMEM, Gibco), dimethyl sulfoxide (DMSO, Sigma), phosphate buffered saline (PBS, Gibco), mouse interleukin-1β enzyme-linked immunosorbent assay kit (Mouse IL-1β ELISA kit, Boster)

[0082] 2. Experimental groups: as shown in Table 5;

[0083] 3. Experimental steps: routine cell culture, cell suspension was inoculated into 12-well plates, incubated in a 37°C, 5% CO2 incubator for 18-24h. Take out the culture plate, discard the original culture medium in the well, and add 1mL of culture medium containing 1.5% test sample and peptidoglycan (LPS) to each well of the sample group. The model group added culture medium with LPS as a stimulus, the positive control added 1mL of dexamethasone and LPS culture medium, and the blank control group only added culture medium and cultured for 24h. The supernatant was collected and stored at -80°C, and the inflammatory factor IL-1β was determined using an ELISA kit. The data were analyzed using SPSS and expressed as mean ± standard deviation. If P < 0.05, the difference was considered statistically significant. IL-1β inhibition rate (%) = (IL-1β content in the model control group - IL-1β content in the sample group) / IL-1β content in the model control group.

[0084] The experimental results are shown in Table 6.

[0085] Table 5

[0086] Group Culture conditions Induction conditions Blank control group (NT) Culture medium / Model control group (M) Culture medium LPS Test sample set (TA) 1.5% sample culture medium LPS Positive control group (PC) Dexamethasone-containing culture medium LPS

[0087] Table 6

[0088] Group Inhibition rate (%) Positive control group (PC) 85.55*** Example 1 27.85** Example 2 27.56** Example 3 15.38* Example 4 15.80* Example 5 20.17* Example 6 21.86* Example 7 27.26** Example 8 14.31* Example 9 13.69* Comparative Example 1 <![CDATA[5.15 ns ]]> Comparative Example 2 <![CDATA[5.01 ns ]]> Comparative Example 3 <![CDATA[3.09 ns ]]> Comparative Example 4 <![CDATA[3.14 ns ]]> Comparative Example 5 <![CDATA[3.45 ns ]]> Comparative Example 6 <![CDATA[3.61 ns ]]> Comparative Example 7 <![CDATA[4.89 ns ]]> Comparative Example 8 <![CDATA[3.92 ns ]]> Comparative Example 9 <![CDATA[3.80 ns ]]>

[0089] Note: Compared with the model group, significance is indicated by *, P value < 0.05 is indicated by *, P value < 0.01 is indicated by **, P value < 0.001 is indicated by ***, and no significance, P value > 0.05 is indicated by ns.

[0090] Interleukin-1β (IL-1β) plays an important role in immune regulation and inflammatory response, and is considered to be one of the main endogenous mediators causing fever in the inflammatory response. The acne-removing composition for regulating dietary metabolism prepared by the present invention has a good anti-inflammatory effect.

[0091] From the comparison of Examples 1-9, it can be seen that the weight of the components will affect the comprehensive effect of the composition for regulating dietary metabolism to improve acne. When the weight of the components is further selected within a preferred range, the anti-inflammatory effect of the obtained acne-removing composition for regulating dietary metabolism is stronger.

[0092] From the comparison of Example 1 and Comparative Examples 1-9, it can be seen that the five components of the anti-acne composition for regulating dietary metabolism of the present invention, namely, Rehmannia root extract, Peucedanum pekinensis extract, 10-hydroxydecanoic acid, anthocyanin, and Guaiacum officinale extract, can cooperate with each other and none of them is indispensable.

[0093] Effect Example 3 Application Test

[0094] This effect example tests the improvement effects of the application example, comparative application example and blank application example on acne, oil content, skin barrier and pore size in people with sensitive skin.

[0095] The specific test method is as follows: According to the "Technical Specifications for Safety of Cosmetics" (2015), volunteers with sensitive skin aged 18-45 (lactic acid stinging score>3) were selected and randomly divided into 20 groups, 5 people in each group, and the volunteers had to have at least 4-10 obvious acne. Under normal circumstances, volunteers continued to use the product on their entire face for 14 days; every morning and evening, after cleansing and moisturizing, volunteers took an appropriate amount of lotion and applied it to the face, massaged for absorption, and the acne area could be overlapped. The entire face was used once in the morning and evening, and a follow-up visit was conducted on the 0th, 3rd, 7th, and 14th days. The present invention only presents the improvement rate data for 14 days. On the day of the volunteer's visit, the test area washed its face with clean water without applying any product, and sat quietly in an air-conditioned room with a temperature of 21±1°C and a humidity of 50±10% for 20 minutes. The improvement of facial acne indicators was quantified and photographed using instruments, including acne counts (classification counts: comedones and papules, using VISIA and doctor assessment respectively), Sebumeter SM 815 to test oil content, Primos CR (5.8E) to test pore size, and Tewameter TM Hex to measure skin barrier. Improvement rate on day 14 = (average value on day 0 - average value on day 14) / average value on day 0 × 100%;

[0096] The results are shown in Table 7.

[0097] Table 7

[0098]

[0099]

[0100]

[0101] Note: Compared with the blank control group, significance is indicated by *, P value < 0.05 is indicated by *, P value < 0.01 is indicated by **, P value < 0.001 is indicated by ***, no significance, P value > 0.05 is indicated by ns.

[0102] Figure 1 The figures are pictures showing the improvement effect of facial acne on a human body before and after 14 days of using the products of Application Example 1 and Comparative Application Example 1; wherein, Figure (a) is a picture showing the improvement effect of facial acne on a human body before and after 14 days of using the products of Application Example 1, and Figure (b) is a picture showing the improvement effect of facial acne on a human body before and after 14 days of using the products of Comparative Application Example 1;

[0103] Figure 2 The figures are the improvement effect pictures of human facial pores before and after 14 days of using the products of Application Example 1 and Comparative Application Example 1; wherein, Figure (c) is the improvement effect picture of human facial pores before and after 14 days of using the products of Application Example 1, and Figure (d) is the improvement effect picture of human facial pores before and after 14 days of using the products of Comparative Application Example 1.

[0104] Depend on Figure 1-2 It can be seen that the emulsion prepared in Application Example 1 of the present invention has good improvement on facial acne and pores after 14 days of use. As can be seen from the above table, the emulsion prepared in Application Example 1 of the present invention can regulate water-oil balance, unclog pores, repair skin barrier, and improve and prevent acne.

[0105] Although there is a certain natural recovery effect for skin acne, due to the continued presence of inflammation in the underlying skin, it is still faced with the risk of increased acne, aggravation or slow healing of acne. As can be seen from effect examples 1-2, the anti-acne composition for regulating dietary metabolism proposed by the present invention can exert significant oil control and anti-inflammatory effects from a mechanism perspective, and has the potential to prevent acne and accelerate acne improvement. Therefore, it can be further seen from this effect example that in application examples 1-9, compared with the blank application example, the anti-acne composition for regulating dietary metabolism accelerates the healing of acne, significantly reduces the number of acne and papules, and plays a practical prevention and improvement effect. However, the weight of the components will affect the comprehensive effect of the emulsion. When the weight of the components in the further selected anti-acne composition for regulating dietary metabolism is within a preferred range, the comprehensive effect of the obtained emulsion is better.

[0106] It can be seen from Application Example 1 and Comparative Application Examples 1-9 that no matter when any one of the anti-acne composition for regulating dietary metabolism is missing, or when other components with similar effects are used to replace the corresponding components in the anti-acne composition for regulating dietary metabolism, the obtained emulsion cannot achieve the effect of the present invention.

[0107] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit the scope of protection of the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the essence and scope of the technical solution of the present invention.

Claims

1. An anti-acne composition for regulating dietary metabolism, characterized in that: The composition comprises component A and component B: The component A comprises the following ingredients in parts by weight: 0.1-0.5 parts of Rehmannia glutinosa extract and 0.01-0.2 parts of Peucedanum pekinensis extract; The component B comprises the following ingredients in parts by weight: 0.005-0.3 parts of 10-hydroxydecanoic acid, 0.0005-0.008 parts of anthocyanin, and 0.5-3 parts of guaiac extract.

2. The anti-acne composition for regulating dietary metabolism according to claim 1, characterized in that: The component A comprises the following ingredients in parts by weight: 0.15-0.25 parts of Rehmannia glutinosa extract and 0.05-0.15 parts of Peucedanum peucedanum extract; The component B comprises the following ingredients in parts by weight: 0.04-0.1 parts of 10-hydroxydecanoic acid, 0.001-0.005 parts of anthocyanin, and 0.8-1.5 parts of guaiac extract.

3. The anti-acne composition for regulating dietary metabolism according to claim 1, characterized in that: The weight ratio of component A to component B is: component A: component B = (0.2-0.4): (1-1.5).

4. The anti-acne composition for regulating dietary metabolism according to claim 1, characterized in that: In the component A, the weight percentage of Rehmannia root extract is 60-70%.

5. The anti-acne composition for regulating dietary metabolism according to claim 1, characterized in that: In the component B, the weight percentage of 10-hydroxydecanoic acid is 4.5-7.5%.

6. The anti-acne composition for regulating dietary metabolism according to claim 1, characterized in that: The preparation method of the Rehmannia root extract comprises the following steps: drying, crushing and sieving the Rehmannia root to obtain coarse Rehmannia root powder; then adding an ethanol solution for ultrasonic extraction, filtering and concentrating the extract to obtain the Rehmannia root extract.

7. The anti-acne composition for regulating dietary metabolism according to claim 6, characterized in that: The volume fraction of the ethanol is 40-90%.

8. The anti-acne composition for regulating dietary metabolism according to claim 6, characterized in that: The weight ratio of the ethanol solution to the Rehmannia glutinosa powder is 8-12:1; and / or the temperature of the ultrasonic extraction is 30-60°C, the time of the ultrasonic extraction is 20-60min, and the number of extractions is 1-3 times.

9. Use of the anti-acne composition for regulating dietary metabolism according to any one of claims 1 to 8 in the preparation of skin products.

10. A skin care product, characterized in that: The skin product comprises the anti-acne composition for regulating dietary metabolism as claimed in any one of claims 1 to 8.

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