Traditional Chinese medicine composition for treating insomnia and anxiety as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention relates to the technical field of traditional Chinese medicines, and aims to solve the technical problems that the traditional treatment modes for insomnia and anxiety mostly depend on chemically synthesized sedative or antidepressant drugs at present, but the insomnia and anxiety often have side effects such as sleepiness, hypomnesis and addiction after being used for a long time, and the insomnia and anxiety are easy to relapse after drug withdrawal. The invention discloses a traditional Chinese medicine composition for treating insomnia and anxiety, the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6 parts of tribulus terrestris, 8-10 parts of cortex lycii radicis, 8-10 parts of radix curcumae, 8-10 parts of herba artemisiae scopariae, 6-10 parts of chrysanthemum, 10-12 parts of roasted rhizoma atractylodis macrocephalae, 4 parts of inula flower and 6-8 parts of gypsum, and a preparation method of the traditional Chinese medicine composition comprises the following steps: taking the raw materials, extracting, and filtering to obtain filtrate; the traditional Chinese medicine extract is obtained by concentrating and drying the obtained extracting solution, and the traditional Chinese medicine extract is mixed with pharmaceutically available carriers or auxiliary materials to be prepared into the required dosage form which can be used for treating insomnia and anxiety symptoms caused by deficiency-heat of upper jiao and has the effects of clearing heat, relieving depression, soothing the nerves and stabilizing the mind.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating insomnia and anxiety, and a preparation method and application thereof. Background Art

[0002] Insomnia and anxiety are increasingly common mental health problems in modern society, posing a serious threat to an individual's quality of life, work efficiency, and overall physical and mental health. According to the World Health Organization, more than 300 million people worldwide suffer from insomnia, and the prevalence of anxiety disorders is also high.

[0003] In TCM theory, the human body is divided into the upper, middle, and lower burners, of which the upper burner mainly includes the heart, lungs, and the head and face. Upper burner deficiency heat refers to heat symptoms in the upper burner, especially the heart and lungs, caused by insufficient yin fluid in the body, internal generation of deficiency fire, or external wind-heat evil entering the body and turning into heat. According to TCM's theory that "the heart governs the mind", excessive heart fire can cause restlessness and anxiety; at the same time, heart fire disturbs the mind, affects sleep, and causes insomnia. In addition, the lungs govern qi, control breathing, flow to all meridians, and regulate joints. Lung heat can also disturb the mind and aggravate insomnia and anxiety symptoms.

[0004] Currently, Western medicine treatments for insomnia and anxiety mostly rely on chemically synthesized sedatives or antidepressants. Although these drugs may be effective in the short term, long-term use is often accompanied by side effects such as drowsiness, memory loss, and addiction, and is prone to relapse after discontinuation of the drug.

[0005] Traditional Chinese medicine usually has few side effects and low cost. Therefore, it is of great significance to develop traditional Chinese medicine suitable for insomnia and anxiety caused by upper-jiao deficiency heat. Summary of the invention

[0006] The technical problem to be solved by the present invention is to overcome the defects of the above-mentioned technology and provide a Chinese medicine composition for treating insomnia and anxiety and a preparation method and application thereof.

[0007] To solve the above technical problems, the technical solution provided by the present invention is a traditional Chinese medicine composition for treating insomnia and anxiety, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 6 parts of Tribulus terrestris, 8-10 parts of Lycium bark, 8-10 parts of Curcuma aromatica, 8-10 parts of Artemisia capillaris, 6-10 parts of Chrysanthemum, 10-12 parts of stir-fried Atractylodes macrocephala, 4 parts of Inula flower, and 6-8 parts of Gypsum.

[0008] Furthermore, the Chinese medicine composition comprises the following raw materials in parts by weight: 6 parts of Tribulus terrestris, 8 parts of Lycium bark, 8 parts of Curcuma aromatica, 8 parts of Artemisia capillaris, 6 parts of Chrysanthemum, 10 parts of stir-fried Atractylodes macrocephala, 4 parts of Inula flower, and 6 parts of Gypsum.

[0009] Furthermore, the Chinese medicine composition comprises the following raw materials in parts by weight: 6 parts of Tribulus terrestris, 9 parts of Lycium bark, 9 parts of Curcuma aromatica, 9 parts of Artemisia capillaris, 8 parts of Chrysanthemum, 11 parts of stir-fried Atractylodes macrocephala, 4 parts of Inula flower, and 7 parts of Gypsum.

[0010] Furthermore, the Chinese medicine composition comprises the following raw materials in parts by weight: 6 parts of Tribulus terrestris, 10 parts of Lycium bark, 10 parts of Curcuma aromatica, 10 parts of Artemisia capillaris, 10 parts of Chrysanthemum, 12 parts of stir-fried Atractylodes macrocephala, 4 parts of Inula flower, and 8 parts of Gypsum.

[0011] The second object of the present invention is to provide a method for preparing the above-mentioned Chinese medicine composition, comprising the following steps:

[0012] Step 1) taking the above raw materials by weight, mixing Tribulus terrestris, Lycium bark, Curcuma, Artemisia capillaris, Chrysanthemum, Roasted Atractylodes macrocephala and Inula flower, placing the obtained mixture and gypsum into different containers, soaking them in clean water for 40-60 minutes, taking them out and setting aside;

[0013] Step 2) putting the soaked gypsum into a decoction pot, adding 3-5 times the weight of water of the gypsum, first boiling it over high heat, then turning to low heat and decocting for 20-30 minutes until the liquid medicine is milky white, and naturally cooling it to room temperature to obtain the gypsum liquid medicine, which is taken out for later use;

[0014] Step 3) putting the soaked mixture into a decoction pot, heating it to a slightly boiling state, adding the obtained gypsum solution, and continuing to decoct for 40-60 minutes, and filtering to obtain a clear extract;

[0015] Step 4) concentrating the extract under reduced pressure to 0.2-0.25 times the original volume to obtain a concentrated solution;

[0016] Step 5) vacuum drying the concentrated solution, controlling the pressure at 4-6 kPa and the drying temperature at 30-60° C., and vacuum drying for 35-55 minutes to obtain a Chinese medicine composition.

[0017] The third object of the present invention is to provide the above-mentioned Chinese medicine composition for preparing medicine for treating insomnia and anxiety symptoms.

[0018] Furthermore, the present invention also provides a medicine for treating insomnia and anxiety, comprising the above-mentioned Chinese medicine composition and medically acceptable excipients.

[0019] Furthermore, the medically acceptable excipients include one or more of surfactants, suspending agents, fillers, antibacterial agents, and protective agents.

[0020] Furthermore, the dosage form of the drug is granules, pills, tablets, powders or capsules.

[0021] Furthermore, the drug in different dosage forms can be prepared according to conventional preparation methods in the art.

[0022] The Treatise on Febrile Diseases summarizes the causes of anxiety and insomnia into two extremes: deficiency and excess. Deficiency syndrome mainly includes deficiency of blood in the heart and liver, deficiency of kidney yang, and deficiency of kidney yin. Excess syndrome is often characterized by upper jiao stagnation of heat disturbing the heart, internal disturbance of shaoyang stagnation of heat, disharmony of yangming intestinal qi, and stagnation of damp heat. According to the theory of three jiao in traditional Chinese medicine, the human body is divided into upper, middle, and lower jiao. The upper jiao governs the heart and lungs, and belongs to fire. Its qi runs from top to bottom, warming the lower jiao. The lower jiao governs the kidneys, large and small intestines, and bladder, and belongs to water. Its qi runs from bottom to top, nourishing the upper jiao. The middle jiao governs the spleen and stomach, and is the hub of the ascending and descending qi of the upper and lower jiao. If the qi of the middle jiao is blocked, the qi of the upper and lower jiao will be blocked, the heart fire cannot go down to warm the kidney water, and the kidney water cannot go up to help the heart fire, forming the syndrome of upper heat and lower cold. The blockage of the qi of the middle jiao is mostly caused by the dysfunction of the spleen and stomach. The spleen governs the transportation and transformation of the clear, and the stomach governs the reception and descending of the turbid. If the spleen and stomach are dysfunctional, the upper and lower qi will not flow smoothly. When the upper-jiao virtual fire is excessive, the body fluid is consumed too quickly, resulting in dry mouth and tongue, disturbed mind, and irritability. At the same time, the upper-jiao virtual fire can cause the heart and kidney to be out of harmony, making it difficult for the mind to be at peace, thus causing insomnia and dreaminess.

[0023] Aiming at the pathogenesis of anxiety and insomnia, the present invention adopts a reasonable formula, with chrysanthemum as the main drug, which is sweet, bitter and slightly cold in nature, and enters the lung and liver meridians, and has the effects of dispersing wind-heat, calming the liver and improving eyesight, and clearing away heat and detoxifying. Modern pharmacological studies have shown that the flavonoids and amino acids contained in chrysanthemum have sedative and anti-anxiety effects;

[0024] Curcuma, Rehmannia root bark and Artemisia capillaris are used as ministerial drugs. Curcuma root belongs to the heart, liver and lung meridians, and has the functions of promoting blood circulation and relieving pain, promoting qi and relieving depression, clearing the heart and cooling blood. It can help chrysanthemum to strengthen the effects of soothing the liver and relieving depression, clearing the heart and calming the mind; Rehmannia root bark belongs to the lung, liver and kidney meridians, and has the effects of cooling blood and removing steam, clearing the lungs and reducing fire. It can cooperate with chrysanthemum to clear the upper-jiao virtual heat, moisten the lungs and reduce fire, and relieve anxiety symptoms; Artemisia capillaris belongs to the spleen, stomach, liver and gallbladder meridians, and has the effects of clearing heat and dampness, promoting bile and relieving jaundice. This prescription takes its functions of clearing heat and dampness to remove damp heat in the body and indirectly relieve anxiety and insomnia.

[0025] Tribulus terrestris and Inula flower are used as adjuvant drugs. Tribulus terrestris belongs to the liver meridian, has the effects of calming the liver and relieving depression, dispersing wind and improving eyesight, can help the main and auxiliary drugs to strengthen the function of soothing the liver and relieving depression, and can also dispersing wind and improving eyesight, and relieve insomnia caused by wind-heat in the liver meridian; Inula flower belongs to the lung, spleen, stomach, and large intestine meridians, has the effects of descending qi and resolving phlegm, descending adverse qi and stopping vomiting, can regulate lung qi, descend qi and resolve phlegm, and relieve anxiety caused by sluggish lung qi;

[0026] Stir-fried Atractylodes macrocephala and Gypsum are used as the guiding drugs. Stir-fried Atractylodes macrocephala belongs to the spleen and stomach meridians, and has the effects of strengthening the spleen and replenishing qi, drying dampness and promoting diuresis, which can harmonize the spleen and stomach, enhance the absorption of drug efficacy, and can also dry dampness and promote diuresis, and remove dampness. Gypsum belongs to the lung and stomach meridians, and has the effects of clearing heat and purging fire, eliminating restlessness and quenching thirst. It cooperates with chrysanthemum and Rehmannia root bark to clear the upper-jiao virtual heat, and can also eliminate restlessness and quench thirst, and relieve restlessness and restlessness. Stir-fried Atractylodes macrocephala and Gypsum can lead all the drugs directly to the diseased area and enhance the efficacy of the whole prescription.

[0027] The advantages of the present invention compared with the prior art are:

[0028] The Chinese medicine composition provided by the present invention is based on traditional Chinese medicine theory and modern pharmacology research results. It is prepared by effectively combining tribulus terrestris, rehmannia root, curcuma, capillaris, chrysanthemum, stir-fried atractylodes, inula flower and gypsum. The Chinese medicine composition is targeted at insomnia and anxiety symptoms caused by upper-jiao deficiency heat, and has the effects of clearing away heat, relieving depression, and calming the nerves. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] Figure 1 This is the result of the open field test of mice in Example 5 of the present invention, wherein a is the activity time of the central area of ​​the mouse, and b is the total movement distance of the mouse.

[0030] Figure 2 This is the result of the hypnosis experiment on mice in Example 5 of the present invention. DETAILED DESCRIPTION

[0031] The following is a further detailed description of a Chinese medicine composition for treating insomnia and anxiety and its preparation method and application in conjunction with the embodiments.

[0032] Example 1 Preparation of granule medicine

[0033] A Chinese medicine composition for treating insomnia and anxiety, comprising the following raw materials in parts by weight: 6 parts of Tribulus terrestris, 9 parts of Lycium bark, 9 parts of Curcuma aromatica, 9 parts of Artemisia capillaris, 8 parts of Chrysanthemum, 11 parts of stir-fried Atractylodes macrocephala, 4 parts of Inula flower, and 7 parts of Gypsum;

[0034] The preparation method of the Chinese medicine composition comprises the following steps:

[0035] Step 1) taking the above raw materials by weight, mixing Tribulus terrestris, Lycium bark, Curcuma, Artemisia capillaris, chrysanthemum, stir-fried Atractylodes macrocephala and Inula flower, placing the obtained mixture and gypsum into different containers, soaking them in clean water for 40 minutes, taking them out and setting aside;

[0036] Step 2) putting the soaked gypsum into a decoction pot, adding 3 times the weight of water of the gypsum, first boiling it over high heat, then turning to low heat and decocting for 20 minutes until the liquid is milky white, cooling it naturally to room temperature, and obtaining the gypsum liquid, which is taken out for later use;

[0037] Step 3) putting the soaked mixture into a decoction pot, heating it to a slightly boiling state, adding the obtained gypsum solution, and continuing to decoct for 40 minutes, filtering, and obtaining a clear extract;

[0038] Step 4) Concentrating the extract under reduced pressure to 0.2 times of the original volume to obtain a concentrated solution;

[0039] Step 5) vacuum drying the concentrated solution, controlling the pressure to 4 kPa, the drying temperature to 35° C., and vacuum drying for 40 minutes to obtain a Chinese medicine composition.

[0040] Starch and lactose are taken according to 5.5% of the weight of the prepared traditional Chinese medicine composition, wherein the ratio of starch to lactose is 1:1, and added to the traditional Chinese medicine composition, and granules are prepared after mixing, so as to obtain the granular medicine.

[0041] Example 2 Pill Drug Preparation

[0042] A Chinese medicine composition for treating insomnia and anxiety, comprising the following raw materials in parts by weight: 6 parts of Tribulus terrestris, 10 parts of Lycium bark, 10 parts of Curcuma aromatica, 10 parts of Artemisia capillaris, 10 parts of Chrysanthemum, 12 parts of stir-fried Atractylodes macrocephala, 4 parts of Inula flower, and 8 parts of Gypsum;

[0043] The preparation method of the Chinese medicine composition comprises the following steps:

[0044] Step 1) taking the above raw materials by weight, mixing Tribulus terrestris, Lycium bark, Curcuma, Artemisia capillaris, Chrysanthemum, Roasted Atractylodes macrocephala and Inula flower, placing the obtained mixture and gypsum into different containers, soaking them in clean water for 60 minutes, taking them out and setting aside;

[0045] Step 2) putting the soaked gypsum into a decoction pot, adding 5 times the weight of water as the gypsum, first boiling it over high heat, then turning to low heat and decocting for 30 minutes until the liquid is milky white, cooling it naturally to room temperature, and obtaining the gypsum liquid, which is then taken out for later use;

[0046] Step 3) putting the soaked mixture into a decoction pot, heating it to a slightly boiling state, adding the obtained gypsum solution, and continuing to decoct for 60 minutes, filtering, and obtaining a clear extract;

[0047] Step 4) concentrating the extract under reduced pressure to 0.25 times of the original volume to obtain a concentrated solution;

[0048] Step 5) vacuum drying the concentrated solution, controlling the pressure to 6 kPa, the drying temperature to 60° C., and vacuum drying for 55 minutes to obtain a Chinese medicine composition;

[0049] Honey is taken according to 3.5% of the weight of the prepared traditional Chinese medicine composition, and is added to the traditional Chinese medicine composition, and the mixture is mixed to form pills, thereby obtaining a pill medicine.

[0050] Example 3 Tablet Drug Preparation

[0051] A Chinese medicine composition for treating insomnia and anxiety, comprising the following raw materials in parts by weight: 6 parts of Tribulus terrestris, 8 parts of Lycium bark, 8 parts of Curcuma aromatica, 8 parts of Artemisia capillaris, 7 parts of Chrysanthemum, 10 parts of stir-fried Atractylodes macrocephala, 4 parts of Inula flower, and 7 parts of Gypsum;

[0052] The preparation method of the Chinese medicine composition comprises the following steps:

[0053] Step 1) taking the above raw materials by weight, mixing Tribulus terrestris, Lycium bark, Curcuma, Artemisia capillaris, chrysanthemum, stir-fried Atractylodes macrocephala and Inula flower, placing the obtained mixture and gypsum into different containers, soaking them in clean water for 40 minutes, taking them out and setting aside;

[0054] Step 2) putting the soaked gypsum into a decoction pot, adding 4 times the weight of water as the gypsum, first boiling it over high heat, then turning to low heat and decocting for 20 minutes until the liquid is milky white, and naturally cooling it to room temperature to obtain the gypsum liquid, which is taken out for later use;

[0055] Step 3) putting the soaked mixture into a decoction pot, heating it to a slightly boiling state, adding the obtained gypsum solution, and continuing to decoct for 60 minutes, filtering, and obtaining a clear extract;

[0056] Step 4) concentrating the extract under reduced pressure to 0.25 times of the original volume to obtain a concentrated solution;

[0057] Step 5) vacuum drying the concentrated solution, controlling the pressure to 5 kPa, the drying temperature to 45° C., and vacuum drying for 45 minutes to obtain a Chinese medicine composition.

[0058] Sodium carboxymethyl starch is taken according to 4.5% of the weight of the prepared traditional Chinese medicine composition and added to the traditional Chinese medicine composition. After mixing, the mixture is compressed into tablets using a tablet press to obtain tablet medicine.

[0059] Example 4 Capsule Drug Preparation

[0060] A Chinese medicine composition for treating insomnia and anxiety, comprising the following raw materials in parts by weight: 6 parts of Tribulus terrestris, 8 parts of Lycium bark, 8 parts of Curcuma aromatica, 8 parts of Artemisia capillaris, 6 parts of Chrysanthemum, 10 parts of stir-fried Atractylodes macrocephala, 4 parts of Inula flower, and 6 parts of Gypsum;

[0061] The preparation method of the Chinese medicine composition comprises the following steps:

[0062] Step 1) taking the above raw materials by weight, mixing Tribulus terrestris, Lycium bark, Curcuma, Artemisia capillaris, chrysanthemum, stir-fried Atractylodes macrocephala and Inula flower, placing the obtained mixture and gypsum into different containers, soaking them in clean water for 50 minutes, taking them out and setting aside;

[0063] Step 2) putting the soaked gypsum into a decoction pot, adding 4 times the weight of water of the gypsum, first boiling it over high heat, then turning to low heat and decocting for 25 minutes until the liquid is milky white, cooling it naturally to room temperature, and obtaining the gypsum liquid, which is taken out for later use;

[0064] Step 3) putting the soaked mixture into a decoction pot, heating it to a slightly boiling state, adding the obtained gypsum solution, and continuing to decoct for 50 minutes, filtering, and obtaining a clear extract;

[0065] Step 4) Concentrating the extract under reduced pressure to 0.2 times of the original volume to obtain a concentrated solution;

[0066] Step 5) vacuum drying the concentrated liquid, controlling the pressure to 4 kPa, the drying temperature to 40° C., and vacuum drying for 35 minutes to obtain a Chinese medicine composition.

[0067] Sodium carboxymethyl starch is taken according to 3.5% of the weight of the prepared traditional Chinese medicine composition and added to the traditional Chinese medicine composition, mixed and granulated, and filled into No. 2 capsules to obtain capsule medicine.

[0068] Example 5 Pharmacodynamics Test

[0069] 1. Experimental content: open field test and hypnosis experiment.

[0070] 2. Experimental animals: 30 SPF male ICR mice weighing 20-25 g were randomly divided into 3 groups, with 10 mice in each group.

[0071] 3. Grouping and Modeling

[0072] 3.1 Grouping: 30 mice were randomly divided into 3 groups, 10 mice in each group, namely normal group, model group and embodiment group.

[0073] 3.2 Modeling:

[0074] Each mouse in the model group and the example group was intraperitoneally injected with FG7142 (a non-selective benzodiazepine inverse agonist) at 9:00 am every day, with an injection dose of 15 mg / kg, once a day;

[0075] Each mouse in the normal group was intraperitoneally injected with normal saline at 9:00 a.m. every day according to the injection standard of 15 mg / kg;

[0076] The mice in the model group and the embodiment group showed loss of circadian rhythm, continuous activity during the day, weight loss, irritability, and increased aggressiveness, and the overall observation was significantly different from that of the normal group, indicating that the modeling was successful.

[0077] 4. Medication

[0078] After the model was successfully established, the mice in the Example group were given oral administration with the granular drug obtained in Example 1 and distilled water as the solvent at a dosage of 15 g / kg.

[0079] The mice in the normal group and the model group were gavaged with an equal amount of normal saline once at 10-11 o'clock every day for one week.

[0080] 5. Open field test

[0081] 5.1 Open field apparatus: an open transparent box with a length of 50 cm, a width of 50 cm, and a height of 40 cm. The bottom is divided into several equal-sized squares, and a camera is installed on the top to record the movement trajectory of the mouse in the open field apparatus.

[0082] 5.2 Test steps:

[0083] Each mouse in the normal group, embodiment group and model group was gently placed in the central area of ​​the open field box and allowed to move freely for 5 minutes. The movement trajectory was recorded by a camera installed on the top of the box. The behavior of the mice within 5 minutes was observed and recorded. The main observation indicators included:

[0084] ① Activity time in the central area: reflects the anxiety level of mice. Anxious mice tend to avoid the central area.

[0085] ②Total moving distance: evaluates the activity level of mice. Anxious mice behave more impatiently and are more active.

[0086] After each mouse is recorded, the box needs to be disinfected and odor eliminated with alcohol.

[0087] After each group of mice completed the experiment, the total moving distance and central area activity time of each group of mice were statistically processed, and the average value was taken to plot Table 1 and Figure 1 .

[0088] Table 1 Summary of open field test results

[0089] Group Total moving distance (m) Central area activity time (s) Normal group 9.93 150 Example Group 10.03 151 Model Group 16.87 61

[0090] The test results are shown in Table 1 and Figure 1 As shown: compared with the normal group, the total moving distance of the mice in the model group increased significantly, while the total moving distance of the mice in the embodiment group was close to that of the normal group;

[0091] At the same time, compared with the normal group, the average activity time of the embodiment group in the central area increased slightly, while the activity time of the model group mice in the central area decreased significantly;

[0092] In summary, the granular drug obtained in Example 1 has an alleviating and therapeutic effect on anxiety.

[0093] 6 Hypnosis Experiment

[0094] 6.1 Test steps

[0095] Fentanyl anesthetic was prepared according to the standard of 0.001-0.002 mg / kg body weight. After modeling and drug treatment, each group of mice was intraperitoneally injected with fentanyl anesthetic. The time from drug administration to complete sleep of each group of mice was observed and recorded for statistical processing. The average value of each group was taken and the results were plotted in Table 2 and Table 2. Figure 2 .

[0096] Table 2 Summary of hypnosis test results

[0097] Group Time from drug administration to falling asleep (s) Normal group 85.23 Example Group 87.01 Model Group 156.27

[0098] The test results are shown in Table 2 and Figure 2 As shown: compared with the normal group, the time from drug administration to falling asleep of the mice in the model group was significantly increased, while the time from drug administration to falling asleep of the mice in the example group was close to that of the normal group, which proved that after the modeling was completed, the anxiety and insomnia behaviors of the mice were improved after being treated with the granules obtained in Example 1 during the drug treatment stage, and were close to returning to normal levels.

[0099] Modern pharmacological research has found that turmeric, stir-fried atractylodes, chrysanthemum, Chinese wolfberry bark and artemisia capillaris contain flavonoids, alkaloids, volatile oils, etc., which have the effects of regulating neurotransmitter levels, anti-oxidation, and anti-inflammatory. They may play a role in treating insomnia and anxiety by improving the brain microenvironment, regulating the function of the hypothalamus-pituitary-adrenal axis, and other mechanisms. The Chinese medicine composition provided by the present invention is based on the theory of traditional Chinese medicine and the results of modern pharmacological research. It is prepared by the effective combination of tribulus terrestris, Chinese wolfberry bark, turmeric, artemisia capillaris, chrysanthemum, stir-fried atractylodes, inula flower and gypsum. The Chinese medicine composition can be used to treat insomnia and anxiety, and can achieve the effects of calming the mind, relieving liver and relieving depression by regulating the functions of human internal organs and balancing yin and yang.

[0100] The present invention and its embodiments are described above, and such description is not restrictive. The drawings show only one embodiment of the present invention, and the actual structure is not limited thereto. In short, if ordinary technicians in the field are inspired by it, without departing from the purpose of the invention, they can design a structure and embodiment similar to the technical solution without creativity, which should belong to the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating insomnia and anxiety, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 6 parts of Tribulus terrestris, 8-10 parts of Lycium bark, 8-10 parts of Curcuma aromatica, 8-10 parts of Artemisia capillaris, 6-10 parts of Chrysanthemum, 10-12 parts of stir-fried Atractylodes macrocephala, 4 parts of Inula flower, and 6-8 parts of Gypsum.

2. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 6 parts of Tribulus terrestris, 8 parts of Lycium bark, 8 parts of Curcuma aromatica, 8 parts of Artemisia capillaris, 6 parts of Chrysanthemum, 10 parts of stir-fried Atractylodes macrocephala, 4 parts of Inula flower, and 6 parts of Gypsum.

3. The Chinese medicine composition according to claim 1, characterized in that The Chinese medicine composition comprises the following raw materials in parts by weight: 6 parts of Tribulus terrestris, 9 parts of Lycium bark, 9 parts of Curcuma aromatica, 9 parts of Artemisia capillaris, 8 parts of Chrysanthemum, 11 parts of stir-fried Atractylodes macrocephala, 4 parts of Inula flower, and 7 parts of Gypsum.

4. The Chinese medicine composition according to claim 1, characterized in that: The Chinese medicine composition comprises the following raw materials in parts by weight: 6 parts of Tribulus terrestris, 10 parts of Lycium bark, 10 parts of Curcuma aromatica, 10 parts of Artemisia capillaris, 10 parts of Chrysanthemum, 12 parts of stir-fried Atractylodes macrocephala, 4 parts of Inula flower, and 8 parts of Gypsum.

5. The method for preparing the Chinese medicine composition according to any one of claims 1 to 4, characterized in that: The following steps are involved: Step 1) taking the above raw materials by weight, mixing Tribulus terrestris, Lycium bark, Curcuma, Artemisia capillaris, Chrysanthemum, Roasted Atractylodes macrocephala and Inula flower, placing the obtained mixture and gypsum into different containers, soaking them in clean water for 40-60 minutes, taking them out and setting aside; Step 2) putting the soaked gypsum into a decoction pot, adding 3-5 times the weight of water of the gypsum, first boiling it over high heat, then turning to low heat and decocting for 20-30 minutes until the liquid medicine is milky white, and naturally cooling it to room temperature to obtain the gypsum liquid medicine, which is taken out for later use; Step 3) putting the soaked mixture into a decoction pot, heating it to a slightly boiling state, adding the gypsum solution obtained in step 2, and continuing to decoct for 40-60 minutes, and filtering to obtain a clear extract; Step 4) concentrating the extract under reduced pressure to 0.2-0.25 times the original volume to obtain a concentrated solution; Step 5) vacuum drying the concentrated solution, controlling the pressure at 4-6 kPa and the drying temperature at 30-60° C., and vacuum drying for 35-55 minutes to obtain a Chinese medicine composition.

6. Use of the Chinese medicine composition according to any one of claims 1 to 4 in the preparation of medicines for treating insomnia and anxiety symptoms.

7. A drug for treating insomnia and anxiety, characterized in that: The invention comprises the Chinese medicine composition according to any one of claims 1 to 4, and medically acceptable excipients.

8. The drug according to claim 7, characterized in that The dosage form of the medicine is granules, pills, tablets or capsules.

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