An active material repair patch and method of making the same

Abstract

This invention provides an active material repair patch, comprising non-woven fabric and release paper. The release paper is formed on the lower end face of the non-woven fabric. A wrapping bag is disposed between the non-woven fabric and the release paper. Specifically, the wrapping bag consists of two sets of wrapping films sealed on all four sides. An air bag I and an air bag II are disposed inside the wrapping bag. Two sets of soluble microneedles are disposed on the other side of the wrapping film adjacent to the non-woven fabric. An active repair material is applied to the corresponding position of the wrapping film adjacent to the release paper. This invention involves applying the non-woven fabric to the affected area, and then pressing the repair patch to puncture the lower wrapping film through the soluble microneedles. The active repair material is then applied to the affected area through the puncture holes. Due to the adhesive properties of the repair material, the gas inside the air bags, released through the puncture holes, accumulates around the applied patch, preventing the non-woven fabric from sticking to the surrounding area and causing pain when the patch is removed for dressing changes.

Description

Technical Field

[0001] This invention relates to the field of wound repair technology, specifically to an active material repair patch and its preparation method. Background Technology

[0002] In daily life, people are prone to accidental skin injuries in various situations. To prevent wound infection, dressings are often used to cover the wound, forming a protective layer on the wound surface as a physical barrier to prevent scarring and promote wound healing. Currently, dressings used for wound repair on the market are mainly divided into gel dressings, liquid dressings, non-woven dressings, and spray dressings.

[0003] Existing wound dressings are generally suitable for shallow wounds or wounds that have been treated at home after hospital care. When patients apply the dressing around the wound and move freely in the later stages of healing, movement can cause the dressing to deform, leading to pain. Furthermore, the prolonged adhesion of the dressing around the wound makes dressing changes painful. Currently available dressings require manual extrusion to release the active ingredients, which is uncomfortable and results in uneven application, failing to meet the desired results. Summary of the Invention

[0004] (a) Technical problems to be solved

[0005] To address the shortcomings of existing technologies, this invention provides an active material repair patch and its preparation method, thereby resolving the problems mentioned in the background section.

[0006] (II) Technical Solution

[0007] To achieve the above objectives, the present invention provides the following technical solution: an active material repair patch, comprising non-woven fabric and release paper, wherein the release paper is formed on the lower end face of the non-woven fabric, and a wrapping bag is provided between the non-woven fabric and the release paper, wherein the wrapping bag is specifically two sets of wrapping films sealed on all four sides, and air pack one and air pack two are provided inside the wrapping bag; two sets of soluble microneedles are provided on the other side of the wrapping film adjacent to the non-woven fabric; an active repair material is applied to the corresponding position of the wrapping film adjacent to the release paper, wherein the active repair material corresponds to the position of one set of soluble microneedles; a pressing part is provided on the side of the non-woven fabric away from the release paper, wherein the pressing part includes an elastic layer and an equalizing part, and the center line of the elastic layer coincides with the center line of the non-woven fabric;

[0008] The active repair material is prepared from the following raw materials in parts by weight:

[0009] Sodium hyaluronate 0.1-40%;

[0010] Active minerals 2-50%;

[0011] Medical-grade petroleum jelly 50-90%;

[0012] The remainder is for auxiliary materials;

[0013] The active minerals are specifically one or more of bioactive glass, tricalcium phosphate, and hydroxyapatite.

[0014] Preferably, it is made from the following raw materials in parts by weight: 5% sodium hyaluronate; 90% active minerals; and the remainder being excipients.

[0015] Preferably, the active repair material is made from the following raw materials in parts by weight: 2% sodium hyaluronate; 25% active minerals; 60% medical petrolatum; and the remainder is excipients.

[0016] Preferably, the active repair material is made from the following raw materials in parts by weight: 1% sodium hyaluronate; 22% active minerals; 70% medical petrolatum; and the remainder is excipients.

[0017] Preferably, the active repair material is made from the following raw materials in parts by weight: 25% sodium hyaluronate; 25% active minerals; 49% medical petrolatum; and the remainder is excipients.

[0018] Preferably, the active repair material is made from the following raw materials in parts by weight: 25% sodium hyaluronate; 30% active minerals; 44% medical petrolatum; and the remainder is excipients.

[0019] Preferably, the active repair material is made from the following raw materials in parts by weight: 20% sodium hyaluronate; 32% active minerals; 47% medical petrolatum; and the remainder is excipients.

[0020] Preferably, the active repair material is made from the following raw materials in parts by weight: 35% sodium hyaluronate; 20% active minerals; 44% medical petrolatum; and the remainder is excipients.

[0021] Preferably, the active repair material is made from the following raw materials in parts by weight: 36% sodium hyaluronate; 38% active minerals; 25.5% medical petrolatum; and the remainder is excipients.

[0022] Preferably, the second air bag surrounds the first air bag inside, and the second air bag corresponds to the position of another set of soluble microneedles.

[0023] Preferably, the side of the air bag of the active repair material facing away from the nonwoven fabric is planar.

[0024] The bioactive glass used in the active repair material is composed of the following raw materials in the indicated weight ratios:

[0025] 20-60% silica;

[0026] Sodium oxide 0-30%;

[0027] Calcium oxide 8-45%;

[0028] Phosphorus pentoxide 2-20%;

[0029] Calcium fluoride 0-5%;

[0030] Boron oxide 0-20%;

[0031] Zinc oxide 0-5%;

[0032] Copper oxide 0-5%;

[0033] Potassium oxide 0-5%;

[0034] Magnesium oxide 0-5%.

[0035] Preferably, the raw materials of the bioactive glass are composed of the following weight ratios: silicon dioxide 34.2%; sodium oxide 0%; calcium oxide 44.9%; phosphorus pentoxide 16.3%; calcium fluoride 0.5%; boron oxide 0%; zinc oxide 0%; copper oxide 0%; potassium oxide 0%; and magnesium oxide 4.6%.

[0036] Preferably, the raw materials of the bioactive glass are composed of the following weight ratios: silicon dioxide 15%; sodium oxide 15%; calcium oxide 27%; phosphorus pentoxide 8%; calcium fluoride 5%; boron oxide 10%; zinc oxide 5%; copper oxide 5%; potassium oxide 5%; and magnesium oxide 5%.

[0037] Preferably, the raw materials of the bioactive glass are composed of the following weight ratios: silicon dioxide 10%; sodium oxide 20%; calcium oxide 18%; phosphorus pentoxide 12%; calcium fluoride 4%; boron oxide 20%; zinc oxide 4%; copper oxide 4%; potassium oxide 4%; and magnesium oxide 4%.

[0038] Preferably, the raw materials of the bioactive glass are composed of the following weight ratios: silicon dioxide 15%; sodium oxide 15%; calcium oxide 32%; phosphorus pentoxide 8%; calcium fluoride 3%; boron oxide 15%; zinc oxide 3%; copper oxide 3%; potassium oxide 3%; and magnesium oxide 3%.

[0039] Preferably, the raw materials of the bioactive glass are composed of the following weight ratios: silicon dioxide 40%; sodium oxide 20%; calcium oxide 22%; phosphorus pentoxide 8%; calcium fluoride 1%; boron oxide 5%; zinc oxide 1%; copper oxide 1%; potassium oxide 1%; and magnesium oxide 1%.

[0040] Preferably, the excipients are one or more selected from glycerin, liquid paraffin, PEG, sodium carboxymethyl cellulose, thickener, and surfactant.

[0041] Preferably, the soluble microneedles have a height of 900 μm, a bottom radius of 180 μm, a tip radius of 10 μm, and a coating film thickness of 300-500 μm.

[0042] Preferably, adhesive layers are fixedly connected to both ends of the elastic layer.

[0043] Preferably, there are two sets of equalizing parts, the equalizing parts are fixedly connected to the nonwoven fabric, and the edge of the equalizing part is aligned with the inner edge of the air bag.

[0044] Preferably, a method for preparing an active material repair patch includes the following steps:

[0045] S1: Select the raw materials for the repair materials according to their components;

[0046] S2: Prepared by mixing active minerals according to the raw materials;

[0047] S3: An active repair material made by mixing the active minerals of S2 with sodium hyaluronate, medical petrolatum, etc. in the above proportions;

[0048] S4: Soluble microneedles are placed on the surface of one set of encapsulation membranes, and an appropriate amount of active repair material is coated on the corresponding position of another set of encapsulation membranes.

[0049] S5: Align the two sets of wrapping films, first heat-press the edges of the two sets of wrapping films to form a wrapping bag, the inside of the wrapping bag is filled with nitrogen gas, and then heat-press to form two sets of air bags.

[0050] S6: Adhere the package bag to the lower end of the non-woven fabric, and then cover the air bag with release paper to form the initial repair patch;

[0051] S7: Adhere the even part to the back of the initial repair patch and leave a gap. Adhere the middle part of the elastic band to the reserved gap to obtain the repair patch.

[0052] Preferably, the preparation process of bioactive glass in the active mineral raw materials is as follows: after mixing the bioactive glass raw materials in a certain proportion, bioactive glass is prepared by sol-gel method or hot melt / melt method, and after aging, drying, pulverizing, and passing through a 50-mesh sieve to obtain the finished product.

[0053] (III) Beneficial Effects

[0054] This invention provides an active material repair patch and its preparation method, which has the following beneficial effects:

[0055] This invention involves applying a non-woven fabric patch to the affected area, then pressing the patch and using soluble microneedles to puncture the underlying membrane. Active repair material is then applied to the affected area through the puncture holes. Because the repair material has a certain degree of adhesion, the gas inside the air pockets, released through the puncture holes, accumulates around the patch, preventing the non-woven fabric from sticking to the surrounding area and causing pain when the patch is removed for dressing changes. Simultaneously, the pressing part, with its adhesive portion, enhances the adhesion of the patch, and under the action of the adhesive portion, the pressing part forms a U-shape, allowing the active repair material to be applied to the affected area. The elastic layer presses against the equalization section, causing the soluble microneedles to pierce the encapsulation membrane. The equalization section then applies pressure from the elastic layer evenly to the repair material, causing it to be squeezed out. As the wound heals and the repair material is consumed, the elastic layer returns to its original shape, maintaining constant pressure on the repair material. This ensures that the repair material is continuously squeezed out, allowing one repair patch to be used until the wound heals. The equalization section ensures that the repair material is continuously squeezed out, and as the wound heals and the active material is consumed, the amount of repair material squeezed out gradually decreases. Attached Figure Description

[0056] Figure 1 This is a schematic diagram of the repair patch structure of the present invention;

[0057] Figure 2 This is a schematic diagram of the upper structure of the nonwoven fabric of the present invention;

[0058] Figure 3 This is a schematic cross-sectional view of the packaging bag of the present invention;

[0059] Figure 4 This is a picture of the back of the repair patch of the present invention;

[0060] Figure 5 This is a schematic diagram showing the unfolded pressing portion of the repair patch of the present invention;

[0061] Figure 6 This is a photograph of the repair material of the present invention;

[0062] Figure 7 The image shown is of the actual repair patch of this invention.

[0063] The labels in the diagram represent the following: 100 release paper, 200 non-woven fabric, 300 wrapping bag, 400 active repair material, 500 air bag one, 600 air bag two, 700 soluble microneedles, 800 elastic layer, 801 adhesive part, and 900 equalization part. Detailed Implementation

[0064] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on top" of the second feature includes the first feature directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature includes the first feature directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0065] The following disclosure provides many different embodiments or examples for implementing various structures of the invention. To simplify the disclosure, specific examples of components and arrangements are described below. These are merely examples and are not intended to limit the invention. Furthermore, reference numerals and / or letters may be repeated in different examples; such repetition is for simplification and clarity and does not in itself indicate a relationship between the various embodiments and / or arrangements discussed. In addition, examples of various specific processes and materials are provided, but those skilled in the art will recognize the application of other processes and / or the use of other materials.

[0066] This invention provides a wound active repair material 400, which is prepared from the following raw materials in parts by weight:

[0067] Sodium hyaluronate 0.1-40%;

[0068] Active minerals 2-50%;

[0069] Medical-grade petroleum jelly 50-90%;

[0070] The remainder is for auxiliary materials;

[0071] The active minerals are specifically one or more of bioactive glass, tricalcium phosphate, and hydroxyapatite.

[0072] The repair material provided by this invention is made from the following raw materials in parts by weight: 5% sodium hyaluronate; 90% active minerals; and the remainder is excipients.

[0073] The repair material provided by this invention is made from the following raw materials in parts by weight: 2% sodium hyaluronate; 25% active minerals; 60% medical petrolatum; and the remainder is excipients.

[0074] The repair material provided by this invention is made from the following raw materials in parts by weight: 1% sodium hyaluronate; 22% active minerals; 70% medical petrolatum; and the remainder is excipients.

[0075] The repair material provided by this invention is made from the following raw materials in parts by weight: 25% sodium hyaluronate; 25% active minerals; 49% medical petrolatum; and the remainder is excipients.

[0076] The repair material provided by this invention is made from the following raw materials in parts by weight: 25% sodium hyaluronate; 30% active minerals; 44% medical petrolatum; and the remainder is excipients.

[0077] The repair material provided by this invention is made from the following raw materials in parts by weight: 20% sodium hyaluronate; 32% active minerals; 47% medical petrolatum; and the remainder is excipients.

[0078] The repair material provided by this invention is made from the following raw materials in parts by weight: 35% sodium hyaluronate; 20% active minerals; 44% medical petrolatum; and the remainder is excipients.

[0079] The repair material provided by this invention is made from the following raw materials in parts by weight: 36% sodium hyaluronate; 38% active minerals; 25.5% medical petrolatum; and the remainder is excipients.

[0080] Furthermore, the raw materials of the bioactive glass are composed of the following weight ratios:

[0081] 20-60% silica;

[0082] Sodium oxide 0-30%;

[0083] Calcium oxide 8-45%;

[0084] Phosphorus pentoxide 2-20%.

[0085] Calcium fluoride 1-5%;

[0086] Boron oxide 1-20%;

[0087] Zinc oxide 1-5%;

[0088] 1-5% copper oxide;

[0089] Potassium oxide 1-5%;

[0090] Magnesium oxide 1-5%.

[0091] In some preferred embodiments of the present invention, the raw materials of the bioactive glass are composed of the following weight ratios: silicon dioxide 34.2%; sodium oxide 0%; calcium oxide 44.9%; phosphorus pentoxide 16.3%; calcium fluoride 0.5%; boron oxide 0%; zinc oxide 0%; copper oxide 0%; potassium oxide 0%; and magnesium oxide 4.6%.

[0092] In some preferred embodiments of the present invention, the raw materials of the bioactive glass are composed of the following weight ratios: silicon dioxide 15%; sodium oxide 15%; calcium oxide 27%; phosphorus pentoxide 8%; calcium fluoride 5%; boron oxide 10%; zinc oxide 5%; copper oxide 5%; potassium oxide 5%; and magnesium oxide 5%.

[0093] In some preferred embodiments of the present invention, the raw materials of the bioactive glass are composed of the following weight ratios: silicon dioxide 10%; sodium oxide 20%; calcium oxide 18%; phosphorus pentoxide 12%; calcium fluoride 4%; boron oxide 20%; zinc oxide 4%; copper oxide 4%; potassium oxide 4%; and magnesium oxide 4%.

[0094] In some preferred embodiments of the present invention, the raw materials of the bioactive glass are composed of the following weight ratios: silicon dioxide 15%; sodium oxide 15%; calcium oxide 32%; phosphorus pentoxide 8%; calcium fluoride 3%; boron oxide 15%; zinc oxide 3%; copper oxide 3%; potassium oxide 3%; and magnesium oxide 3%.

[0095] In some preferred embodiments of the present invention, the raw materials of the bioactive glass are composed of the following weight ratios: silicon dioxide 40%; sodium oxide 20%; calcium oxide 22%; phosphorus pentoxide 8%; calcium fluoride 1%; boron oxide 5%; zinc oxide 1%; copper oxide 1%; potassium oxide 1%; and magnesium oxide 1%.

[0096] Furthermore, the excipients are specifically one or more of glycerin, liquid paraffin, PEG, sodium carboxymethyl cellulose, thickener, and surfactant.

[0097] In another aspect, the present invention provides an active material repair patch, which uses the aforementioned active repair material 400, non-woven fabric 200, and release paper 100. The release paper 100 is formed on the lower end face of the non-woven fabric 200. A wrapping bag 300 is disposed between the non-woven fabric 200 and the release paper 100. The wrapping bag 300 is specifically composed of two sets of wrapping films sealed on all four sides. An air bag 500 and an air bag 600 are disposed inside the wrapping bag 300. Two sets of soluble microneedles 700 are disposed on the other side of the wrapping film adjacent to the non-woven fabric 200. The active repair material 400 is applied to the corresponding position of the wrapping film adjacent to the release paper 100. The active repair material 400 corresponds to the position of one set of soluble microneedles 700. A pressing part is disposed on the side of the non-woven fabric away from the release paper. The pressing part includes an elastic layer 800 and an equalizing part 900. The center line of the elastic layer 800 coincides with the center line of the non-woven fabric.

[0098] Furthermore, the second air bag 600 surrounds the first air bag 500 inside, and the second air bag 600 corresponds to the position of another set of soluble microneedles 700.

[0099] Furthermore, the side of the air bag 500 facing away from the nonwoven fabric 200 is planar.

[0100] Among them, the plane of the air bag 500 facing away from the nonwoven fabric 200 is coated with petroleum jelly.

[0101] Furthermore, the soluble microneedles 700 have a height of 900 μm, a bottom radius of 180 μm, a tip radius of 10 μm, and a coating film thickness of 300-500 μm.

[0102] Furthermore, adhesive layers are fixedly connected to both ends of the elastic layer 800.

[0103] Among them, the thickness of the elastic layer 800 gradually decreases from the bonding side of the adhesive layer to the fixing position of the nonwoven fabric.

[0104] like Figure 4 and Figure 5 As shown, the adhesive layer begins to be housed below the elastic layer 800.

[0105] It should be noted that the elastic layer 800 is an elastic material that can be stretched and can deform and return to its original shape.

[0106] Furthermore, two sets of equalization parts 900 are provided. The equalization parts 900 are fixedly connected to the non-woven fabric, and the edge of the equalization parts 900 is aligned with the inner edge of the air bag.

[0107] The equalization section 900 is made of plastic, such as PE, PET, and ABS.

[0108] Specifically, during use, first align the active material area of ​​the repair material with the wound location, then adhere the repair patch to the wound location. Next, pull out the adhesive part 801 to deform the elastic layer 800, which then adheres to the periphery of the repair patch. The adhesive part 801 enhances the adhesion of the repair patch. Under the action of the adhesive part 801, the pressing part forms a U-shape, pressing the equalizing part 900 from the elastic layer 800, causing the soluble microneedles to pierce the encapsulation membrane. The equalizing part 900 evenly applies the pressure of the elastic layer 800 to the repair material, causing the repair material to be squeezed out. Simultaneously, as the wound continues to heal and the repair material is consumed, the elastic layer 800 will recover its deformation, maintaining a certain pressure on the repair material, thus ensuring that the repair material is continuously squeezed out. Therefore, one repair patch can be used to maintain the wound until it heals.

[0109] Furthermore, the equalization unit 900 ensures that the repair material is continuously extruded, and the amount of repair material extruded can be gradually reduced as the wound heals and the active material is consumed.

[0110] The active repair patch provided by this invention is for use by patients with small or reduced wound size. The patch is applied to the affected area using non-woven fabric 200. By pressing the patch, the encapsulation membrane is punctured by soluble microneedles 700, allowing the active repair material 400 to be applied to the affected area through the puncture. Due to the adhesiveness of the repair material, the gas inside the air pack 600, after being released through the puncture, accumulates around the patch. The air pack 600 then blocks the gas, ensuring that it does not move to the affected area and preventing the non-woven fabric 200 from sticking to the area around the patch, thus avoiding the pain caused by pulling on the area when the patch is removed for dressing changes.

[0111] Among them, the repair patch can effectively reduce the pain caused by the obstruction or incomplete growth of the healing site and surrounding skin, which leads to the pulling pain when the repair patch is torn off during dressing changes.

[0112] Furthermore, because the air pack 2600 has a cushioning effect, it can reduce the pain caused by activity during the patient's healing process.

[0113] This invention also provides a method for preparing an active material repair patch, comprising the following steps:

[0114] S1: Select the raw materials for the repair materials according to their components;

[0115] S2: Prepared by mixing active minerals according to the raw materials;

[0116] S3: An active repair material made by mixing the active minerals of S2 with sodium hyaluronate, medical petrolatum, etc. in the above proportions;

[0117] S4: Soluble microneedles are placed on the surface of one set of encapsulation membranes, and an appropriate amount of active repair material is coated on the corresponding position of another set of encapsulation membranes.

[0118] S5: Align the two sets of wrapping films, first heat-press the edges of the two sets of wrapping films to form a wrapping bag, the inside of the wrapping bag is filled with nitrogen gas, and then heat-press to form two sets of air bags.

[0119] S6: Adhere the package bag to the lower end of the non-woven fabric, and then cover the air bag with release paper to form the initial repair patch;

[0120] S7: Adhere the equalization part 900 to the back of the initial repair patch, leaving a gap, and then adhere the middle part of the elastic band to the reserved gap to obtain the repair patch.

[0121] Furthermore, the preparation process of bioactive glass in the active mineral raw materials is as follows: after mixing the bioactive glass raw materials in a certain proportion, bioactive glass is prepared by sol-gel method or hot melt / melt method, and after aging, drying, pulverizing, and passing through a 50-mesh sieve, the finished product is obtained.

[0122] To further understand the present invention, the following description, in conjunction with embodiments, illustrates the wound active repair material 400 provided by the present invention. The scope of protection of the present invention is not limited by the following embodiments. Example 1

[0123] 1. Formula:

[0124] Sodium hyaluronate 25%; active minerals 25%; medical petrolatum 49%; the remainder is excipients.

[0125] 2. Preparation method:

[0126] Active minerals are mixed in a certain proportion and prepared by sol-gel method or hot melt / melt method. After aging, drying and pulverizing, the material is passed through a 50-mesh sieve to obtain a substance with a particle size of no more than 300um. Then, it is mixed with sodium hyaluronate, medical petrolatum and other materials in the above proportion to make wound active repair material 400.

[0127] Example 2

[0128] 1. Formula:

[0129] Sodium hyaluronate 25%; active minerals 30%; medical petrolatum 44%; the remainder is excipients.

[0130] The active minerals are specifically bioactive glass, tricalcium phosphate, and hydroxyapatite in a 1:1:1 ratio.

[0131] The raw materials for bioactive glass are composed of the following weight ratios: silicon dioxide 34.2%; sodium oxide 0%; calcium oxide 44.9%; phosphorus pentoxide 16.3%; calcium fluoride 0.5%; boron oxide 0%; zinc oxide 0%; copper oxide 0%; potassium oxide 0%; and magnesium oxide 4.6%.

[0132] 2. Preparation method:

[0133] Same as Example 1.

[0134] Example 3

[0135] 1. Formula:

[0136] Sodium hyaluronate 20%; active minerals 32%; medical petrolatum 47%; the remainder is excipients.

[0137] The active minerals are specifically bioactive glass, tricalcium phosphate, and hydroxyapatite in a 1:1:1 ratio.

[0138] The raw materials for bioactive glass are composed of the following weight ratios: silicon dioxide 34.2%; sodium oxide 0%; calcium oxide 44.9%; phosphorus pentoxide 16.3%; calcium fluoride 0.5%; boron oxide 0%; zinc oxide 0%; copper oxide 0%; potassium oxide 0%; and magnesium oxide 4.6%.

[0139] 2. Preparation method:

[0140] Same as Example 1.

[0141] Example 4

[0142] 1. Formula:

[0143] Sodium hyaluronate 35%; active minerals 20%; medical petrolatum 44%; the remainder is excipients.

[0144] The active minerals are specifically bioactive glass, tricalcium phosphate, and hydroxyapatite in a 1:1:1 ratio.

[0145] The raw materials for bioactive glass are composed of the following weight ratios: silicon dioxide 34.2%; sodium oxide 0%; calcium oxide 44.9%; phosphorus pentoxide 16.3%; calcium fluoride 0.5%; boron oxide 0%; zinc oxide 0%; copper oxide 0%; potassium oxide 0%; and magnesium oxide 4.6%.

[0146] 2. Preparation method:

[0147] Same as Example 1.

[0148] Example 5

[0149] 1. Formula:

[0150] Sodium hyaluronate 36%; active minerals 38%; medical petrolatum 25.5%; the remainder is excipients.

[0151] The active minerals are specifically bioactive glass, tricalcium phosphate, and hydroxyapatite in a 1:1:1 ratio.

[0152] The raw materials for bioactive glass are composed of the following weight ratios: silicon dioxide 34.2%; sodium oxide 0%; calcium oxide 44.9%; phosphorus pentoxide 16.3%; calcium fluoride 0.5%; boron oxide 0%; zinc oxide 0%; copper oxide 0%; potassium oxide 0%; and magnesium oxide 4.6%.

[0153] 2. Preparation method:

[0154] Same as Example 1.

[0155] Although embodiments of the invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and alterations can be made to these embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the appended claims and their equivalents.

Claims

1. A repair patch made of active material, characterized in that: The device includes a nonwoven fabric and a release paper. The release paper is formed on the lower end face of the nonwoven fabric. A wrapping bag is provided between the nonwoven fabric and the release paper. The wrapping bag is specifically two sets of wrapping films sealed on all four sides. Air pack one and air pack two are provided inside the wrapping bag. Two sets of soluble microneedles are provided on the other side of the wrapping film adjacent to the nonwoven fabric. An active repair material is applied to the corresponding position of the wrapping film adjacent to the release paper. The active repair material corresponds to the position of one set of soluble microneedles. A pressing part is provided on the side of the nonwoven fabric away from the release paper. The pressing part includes an elastic layer and a balancing part. The center line of the elastic layer coincides with the center line of the nonwoven fabric. The active repair material is prepared from the following: sodium hyaluronate, active minerals, medical petrolatum, and excipients; The active repair material is prepared from the following raw materials in parts by weight: Sodium hyaluronate 1-40%; 20-50% active minerals; Medical grade petroleum jelly 25.5-70%; The remainder is for auxiliary materials; The active minerals are specifically bioactive glass, tricalcium phosphate, and hydroxyapatite in a 1:1:1 ratio; The second air bag surrounds the first air bag inside, and the second air bag corresponds to the position of another set of soluble microneedles; Both ends of the elastic layer are fixedly connected to adhesive layers. The thickness of the elastic layer and the adhesive layer gradually decreases from the adhesive side to the nonwoven fabric fixing position; The equalization section is provided in two sets. The equalization section is fixedly connected to the non-woven fabric, and the edge of the equalization section is aligned with the inner edge of the air bag. The preparation method of the active material repair patch includes the following steps: S1: Select the raw materials for the repair materials according to their components; S2: Prepared by mixing active minerals according to the raw materials; S3: An active repair material made by mixing the active minerals of S2 with sodium hyaluronate, medical petrolatum, etc. in the above-mentioned mass proportions; S4: Soluble microneedles are placed on the surface of one set of encapsulation membranes, and an appropriate amount of active repair material is coated on the corresponding position of another set of encapsulation membranes. S5: Align the two sets of wrapping films, first heat-press the edges of the two sets of wrapping films to form a wrapping bag, the inside of the wrapping bag is filled with nitrogen gas, and then heat-press to form two sets of air bags. S6: Adhere the package bag to the lower end of the non-woven fabric, and then cover the air bag with release paper to form the initial repair patch; S7: Adhere the even part to the back of the initial repair patch and leave a gap. Adhere the middle part of the elastic band to the gap to obtain the repair patch.

2. The active material repair patch according to claim 1, characterized in that: The air bag is planar on the side facing away from the nonwoven fabric.

3. The active material repair patch and its preparation method according to claim 1, characterized in that: The bioactive glass is composed of various elements including silicon dioxide, sodium oxide, calcium oxide, phosphorus pentoxide, calcium fluoride, boron oxide, zinc oxide, copper oxide, potassium oxide, and magnesium oxide.

4. The active material repair patch according to claim 1, characterized in that: The excipients are specifically one or more of the following: glycerin, liquid paraffin, PEG, sodium carboxymethyl cellulose, thickener, and surfactant.

5. The active material repair patch according to claim 1, characterized in that: The soluble microneedles have a height of 900 μm, a bottom radius of 180 μm, a tip radius of 10 μm, and a coating membrane thickness of 300-500 μm.

6. The active material repair patch according to claim 1, characterized in that: The preparation process of bioactive glass in the active mineral raw materials is as follows: after mixing the bioactive glass raw materials in a certain proportion, bioactive glass is prepared by sol-gel method or hot melt / melt method. After aging, drying and pulverizing, the finished product is obtained by passing through a 50-mesh sieve.

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